Endocrine Sciences Clinical Trials Test Menu
Compound
Method
Matrix
17-AlphaHydroxyprogesterone
HPLC MS/MS
Serum
Aldosterone
HPLC MS/MS
Serum
Androstenedione
HPLC MS/MS
Serum
Androsterone
Glucuronide
HPLC MS/MS
Urine
Androsterone
Glucuronide,
Urine/Creatinine Ratio
HPLC MS/MS
Androsterone
Glucuronide, Urine 24
hr (calculation)
Lower Limit of
Quantitation
10 ng/dL
1 ng/dL
10 ng/dL
Upper Limit of
Quantitation
5000 ng/dL
500 ng/dL
2000 ng/dL
Validation Standard
CLIA
Bioanalytical
Bioanalytical
0.1 ug/dL
1000 ug/dL
Serum
0.1 ug/g
1000 ug/g
Bioanalytical
HPLC MS/MS
Serum
1.0 ug/24-hours
(1L)
10,000 ug/24hours (1L)
Bioanalytical
Bile Acids
HPLC MS/MS
Serum
0.4 umol/L
20 umol/L
Bioanalytical
Corticosterone
HPLC MS/MS
Serum
10 ng/dL
2000 ng/dL
Bioanalytical
Cortisol
HPLC MS/MS
Serum
1 ug/dL
100 ug/dL
Bioanalytical
C-Telopeptide
IDS iSYS
Serum
43 pg/mL
6000 pg/mL
Bioanalytical
DHEA
HPLC MS/MS
Serum
20 ng/dL
5000 ng/dL
Bioanalytical
DHEA-Sulfate
HPLC MS/MS
Serum
10 ug/dL
1000 ug/dL
Bioanalytical
DHEA-Sulfate UltraSensitive
HPLC MS/MS
Serum
0.1 ug/dL
20 ug/dL
Bioanalytical
DHT
HPLC MS/MS
Serum
1 ng/dL
500 ng/dL
Bioanalytical
Estradiol
HPLC MS/MS
Serum
1 pg/mL
500 pg/mL
Bioanalytical
Estrone
HPLC MS/MS
Serum
2.5 pg/mL
500 pg/mL
Bioanalytical
Etiocholanolone
Glucuronide
HPLC MS/MS
Urine
0.1 ug/dL
500 ug/dL
Bioanalytical
Etiocholanolone
Glucuronide,
Urine/Creatinine Ratio
HPLC MS/MS
Serum
0.1 ug/g
1000 ug/g
Bioanalytical
Etiocholanolone
Glucuronide, Urine 24
hr (calculation)
HPLC MS/MS
Serum
1.0 ug/24-hours
(1L)
10,000 ug/24hours (1L)
Bioanalytical
Follicle Stimulating
Hormone
Electrochemilumin
escence
Serum
50 mIU/mL
Bioanalytical
Gonadotropin
Releasing Hormone
HPLC MS/MS
Serum
1000 pg/mL
CLIA
Growth Hormone
Beckman Access
DxI, ICMA
Serum
Growth Hormone
Antibodies
Radioligand
binding
Serum
0.1 mIU/mL
10 pg/mL
0.004 ng/mL
35 ng/mL
5 ng/mL
250 ng/mL
Bioanalytical
CLIA
Bioanalytical
For more information, please contact us at [email protected] or call 877-­‐436-­‐3056. Lower Limit of
Quantitation
Upper Limit of
Quantitation
Serum
0.8 ng/mL
208 ng/mL
CLIA
Electrochemilumin
escence
Serum
31 ng/mL
1700 ng/mL
CLIA
IGF Binding Protein - 3
RIA
Serum
0.3 mg/L
undetermined <20
mg/L
CLIA
IGF-I
RIA
Serum
15 ng/mL
1100 ng/mL
CLIA
Insulin
Beckman Access
DxI, ICMA
Serum
0.03 uIU/mL
270 uIU/mL
CLIA
Insulin Antibody
Radioligand
binding
Serum
2 uU/mL
48 uU/mL
Bioanalytical
Luteinizing Hormone
Electrochemilumin
escence
Serum
0.05 mIU/mL
50 mIU/mL
Bioanalytical
Pregnenolone
HPLC MS/MS
Serum
10 ng/dL
2000 ng/dL
Bioanalytical
Progesterone
HPLC MS/MS
Serum
10 ng/dL
5000 ng/dL
Bioanalytical
Prostate Specific
Antigen
Beckman Access
DxI, ICMA
Serum
0.15 ng/mL
148 ng/mL
CLIA
Salivary Cortisol
HPLC MS/MS
Serum
0.01 ug/dL
1 ug/dL
Bioanalytical
Sex Hormone Binding
Globulin
Electrochemilumin
escence, Roche
Elecsys
Serum
10 nM/L
150 nM/L
CLIA
Testosterone
HPLC MS/MS
Serum
2.5 ng/dL
5000 ng/dL
Bioanalytical
Ultra-Sensitive
Androstenedione
HPLC MS/MS
Serum
0.1 ng/dL
100 ng/dL
Bioanalytical
Ultra-sensitive
Testosterone
HPLC MS/MS
Serum
0.2 ng/dL
100 ng/dL
Bioanalytical
Vitamin D, 25-OH D2
HPLC MS/MS
Serum
1 ng/mL
250 ng/mL
CLIA
Vitamin D, 25-OH D3
HPLC MS/MS
Serum
1 ng/mL
250 ng/mL
CLIA
PCR and
sequencing 6
Exons
EDTA
whole
blood
NA
NA
CLIA
Enzymatic
Serum
0.10 mg/dL
80 mg/dL
CLIA
Electrochemilumin
escence
Serum
0.00375 ng/mL
8 ng/mL
CLIA
Autoimmune markers
for type 1 diabetes:
Anti-GAD
Radioligand
binding
Serum
0.5 U/mL
50 U/mL
CLIA
Autoimmune markers
for type 1 diabetes:
Anti-ICA512 (IA2)
Radioligand
binding
Serum
0.8 U/mL
50 U/mL
CLIA
Compound
Method
IGF Binding Protein - 1
ICMA
IGF Binding Protein - 2
RET Gene Analysis
β-Hydroxybutyric Acid
Ultrasensitive CPeptide
Matrix
Validation Standard
For more information, please contact us at [email protected] or call 877-­‐436-­‐3056. Endocrine Sciences Clinical Trials Test Menu
Upper Limit of
Quantitation
Method
Autoimmune markers
for type 1 diabetes:
Anti-insulin
Radioligand
binding
Serum
2.0 µU/mL
48 µU/mL
CLIA
Autoimmune markers
for type 1 diabetes:
Anti-ZnT8
ELISA
Serum
10 U/mL
500 U/mL
CLIA
Serum
0.26%
10.9%
CLIA
Serum
0.5 pg/mL
50 pg/mL
CLIA
Serum
0.1 ng/dL
10 ng/dL
CLIA
Serum
3β 25 OH vit
D2, 3α 25 OH
vit D2, 3β 25
OH vit D3, 3α
25 OH vit D3,
each 0.5 ng/mL
3β 25 OH vit D2,
3α 25 OH vit D2,
3β 25 OH vit D3,
3α 25 OH vit D3,
each 62 ng/mL
Bioanalytical
Serum
Cholecalciferol
1 ng/mL
Ergocalciferol
1 ng/mL
Cholecalciferol
100 ng/mL
Ergocalciferol
100 ng/mL
Bioanalytical
Electrochemilumin
escence
Serum
0.4 µg/mL
6 µgmdL
CLIA
Anti-infliximab
Electrochemilumin
escence
Serum
22 ng/mL
4000 ng/mL
CLIA
Adalimumab
Electrochemilumin
escence
Serum
0.625 µg/mL
16 µg/mL
CLIA
Antiadalimumab
Electrochemilumin
escence
Serum
25 ng/mL
4900 ng/mL
CLIA
Methotrexate
polyglutamate
HPLC MS/MS
EDTA
Whole
Blood
2.5 nmol/L
2500 nmol/L
CLIA
Thiopurine
metabolites
HPLC MS/MS;
Reported in
pmol/8x10e8
RBC’s
EDTA
Whole
Blood
0.5 pmol/µL
lysate
50 pmol/µL lysate
Bioanalytical
Free Progesterone
Free T3
Free T4
3-epi-25Hydroxyvitamin D
Nutritional vitamin D
Equilibrium
Dialysis
Equilibrium
Dialysis HPLC
MS/MS
Equilibrium
Dialysis HPLC
MS/MS
HPLC MS/MS
HPLC MS/MS
Matrix
Lower Limit of
Quantitation
Compound
Validation Standard
Immunosuppressive TDM and management
Infliximab
For more information, please contact us at [email protected] or call 877-­‐436-­‐3056.