Name _________________________
Block ________
Internet Karyotyping Activity
Extra Credit: Complete replace a Quiz Grade
Site 1: http://learn.genetics.utah.edu/content/begin/traits/
Click on the MAKE A KARYOTYPE site & complete the web activity. (2) Click on USING KARYOTYPES TO
PREDICT GENETIC DISORDERS and complete that web activity. Now, click on Quiz and complete it. You
must show me the quiz results BEFORE you can continue on with the activity.
Quiz grade: ___________out of 8
Answer the following scenarios using: normal male, normal female, Turner, Klinefelter, or Down
syndrome.
XX = __________________________
2 chromosomes on the 21st = _________________________
X = _________________________
XXY = _________________________
XY = _________________________
3 chromosomes on the 21st = _________________________
In this next activity, you will use a computer model to look at chromosomes and prepare a karyotype.
You will diagnose patients for abnormalities and learn the correct notation for characterizing
karyotypes.
Site 2: The Biology Project at www.biology.arizona.edu
Look to the left side of the screen for Activities. Look under Human Biology and click on the
Karyotyping link to move to the activity.
Read the Introduction. As you read answer the following questions.
1. How many pairs of chromosomes are in a human karyotype? ___________________________
2. What dye is used to stain the chromosomes? ________________________________________
3. What causes a dark band on the chromosome? ______________________________________
4. Bands do not represent single genes. How many genes can the smallest of bands represent?
______________________________________________________________________________
5. What are the 4 characteristics used to compare chromosomes?
a.____________________________________________________________
b.____________________________________________________________
c.____________________________________________________________
d.____________________________________________________________
6. What is a homologous chromosome? (This is from your notes) ____________________________
7. What is an autosome? (This is from your notes) ________________________________________
1. Click on Patient Histories at the bottom of the page. This will pull up 3 patient histories.
2. Click on the “Complete Patient A’s Karyotype” and begin the matching of chromosomes. You
will look at the chromosome in the upper left corner of the screen. Analyze it and then click on
one of the chromosomes highlighted in blue. The program will tell you whether you are right or
not. If correct it will give you another chromosome in the upper left corner. If you are incorrect it
will give you information that will help you make a match.
3. Read that information carefully and compare the 2 chromosomes in the upper left corner. Click
on the try again button and this will take you back to the karyotype so that you can make
another choice.
Hint: Use the characteristics in #4 above to help make homologous chromosome matches.
You will not be able to proceed until you have correctly matched all the
chromosomes.
Name _________________________
Block ________
Patient A History and Diagnosis
What is the common name for epithelial cells? ______________________
1. (A.1) What notation would you use to characterize Patient A's karyotype?
____________________________________________________________________
2. (A.2) What diagnosis would you give for Patient A? (Choose from the choices listed in the box)
____________________________________________________________________
Patient A history: is the nearly full-term ___________of a ______________________female.
Chromosomes were obtained from fetal ___________________ cells acquired through
_____________________.
Patient B History and Diagnosis
3. (B.1) What notation would you use to characterize Patient B's karyotype?
________________________________________________________________________
4. (B.2) What diagnosis would you give for Patient B? _____________________________
Patient B history: is a ___________old __________ who is trying to identify a cause for his
infertility. Chromosomes were taken from the nucleated cells of the patient’s ____________.
Patient C History and Diagnosis
5. (C.1) What notation would you use to characterize Patient C's karyotype?
_______________________________________________________________________
6. (C.2) What diagnosis would you give for Patient C? ____________________________
Patient C history: Patient C died shortly after ______________, with a multitude of abnormalities,
including polydactyly and a cleft lip. Chromosomes were taken from a _________________ sample.
Site 2: http://bluehawk.monmouth.edu/~bio/karyotypes.htm
Try your hand as a lab tech. Click Karyotyping Lab to view what your karyotype should look like.
Start the sorting processes by clicking the START button. Arrange the chromosomes from Largest 
Smallest and place the chromosomes in their homologous pairs (homo = same). Analyze the
karyotype and write a diagnosis in the box provided. For "diagnosis" write which chromosome set (#)
has the abnormality (example. # 21 has three chromosomes). Print your answers in the space below.