ALINA M. VASILESCU
International Centre of Biodynamics, 1B Intrarea Portocalelor, 060101, Bucharest
Phone: work :( +40) 21 310-4361; cell: 0731 623 780, email: [email protected]
SCIENTIFIC INTERESTS:
(Bio)sensors and their application to real samples; study of protein interactions
WORK HISTORY:

Chemist, International Centre of Biodynamics, Bucharest
01/2011-present
Study of Protein Aggregation (Marie Curie International Reintegration Grant)
 Chemist, Analytical Operations , Apotex Inc,
Richmond Hill, Canada,
01/2004- 08/2010
Method Development, Method Transfer, Method Validation, Stress Study, Analytical
investigations using UPLC, HPLC, Ion Chromatography, GC, LC/MS, Dissolution, In
vitro release (Franz cell), for Raw Materials and Drug products, including Oncology
products

Postdoctoral fellow, University of Toronto,
Faculty of Chemistry, Toronto, Canada
06/2003 - 12/2003
A new piezoelectric material and its application in acoustic biosensors. Used TOFSecondary Ion Mass Spectrometry, XPS and piezoelectric biosensors to study surface
chemistry and protein adsorption. Applied Multivariate statistical methods (PCS,
SIMCA) .

Chemist, Innopharm, Toronto, Canada
11/2002 - 06/2003
CoA testing for Raw Material and Drug Products,, Method Transfer and Method
validation, physical tests, wet chemistry).

Researcher , University of Bucharest, Faculty of Chemistry
07/2001 – 12/2001
Development of amperometric detectors for NADH and hydrogen peroxide.
 Chemist, Deputy Chief of Laboratory for Instrumental Analysis ,
CNIEP LAREX, Bucharest,
10/1994 – 11/1996
CoA testing and method development for of food, oil, cosmetic and mineral products,
using AAS, Xmeasurements.
EDUCATION
2001 Ph.D. thesis, University of Perpignan, France/University of Bucharest, Romania : :
development of amperometric enzyme sensors for wine processing control
ALINA M. VASILESCU - Page 2 of 4
1997 M Sc. in Chemistry, University of Bucharest, Romania; program included a 4-month
research program in France (University of Perpignan): cyanobacteria-based biosensors for
detection of pollutants ( TEMPUS European project)
1996 M Sc in Applied Enzymology, University of Bucharest, Romania:“Study of
peroxidase activity in wines from Valea Calugareasca vineyard”
1994 B Sc in Analytical Chemistry, University of Bucharest, Romania
COURSES, SPECIALIZATION PROGRAMS:
1. “Validation of Pharmaceutical Processes and Equipment”, Seneca College, Toronto,
Canada, 2007
2. “Electrochemical analysis“, Bordeaux, France (2001)
3. “Biosensors based on screen-printed electrodes“ Bristol, England. (1999)
PUBLICATIONS
1.
Vasilescu A, Ballantyne SM , Cheran L-E, Thompson M.”Surface properties and
electromagnetic excitation of a piezeoelectric gallium phosphate biosensor”, Analyst 130,
213-220 (2005)
2.
Vasilescu A, Andreescu S, Bala C, Litescu S C, Noguer T, Marty J-L. “Screenprinted electrodes with electropolymerized Meldola Blue as versatile detectors in
biosensors”, Biosens Bioelectron 18, 781-790 (2003)
3.
Vasilescu A, Noguer T, Andreescu S, Calas-Blanchard C, Bala C, Marty JL.”Strategies for developing NADH detectors based on Meldola Blue and screen-printed
electrodes: a comparative study”, Talanta 59 (4), 751-765 (2003)
4.
Avramescu A, Andreescu S, Noguer T, Bala C, Andreescu D, Marty J-L .
”Biosensors designed for environmental and food quality control based on screen-printed
graphite electrodes with different configurations”, Anal Bioanal Chem 374, 25-32 (2002)
5.
Avramescu A, Noguer T, Avramescu M, Marty J-L. ”Screen-printed biosensors
for the control of wine quality based on lactate and acetaldehyde determination ”, Anal
Chim Acta 458, 203-213 (2002)
6.
Andreescu S, Avramescu A, Bala C, Magearu V, Marty J-L. “Detection of
organophosphorus insecticides with immobilized acetylcholinesterase: Comparative study
between two enzyme sensors”, Anal Bioanal Chem 374, 39-45 (2002)
7.
Noguer T, Tencaliec A, Calas-Blanchard C, Avramescu A, Marty J-L.
”Interference –free biosensors based on on screen-printing technology and sol-gel
immobilization for determination of acetaldehyde in wine”, Journal of AOAC
International 85(6), 1382-1389 (2002)
8.
Avramescu A, Noguer T, Magearu V, Marty J-L. ” Chronoamperometric
determination of D-lactate using screen-printed enzyme sensors ”, Anal Chim Acta 433,
81-88 (2001)
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ALINA M. VASILESCU - Page 3 of 4
9.
Noguer T, Balasoiu A M, Avramescu A, Marty JL. ”Development of a disposable
biosensor for the detection of metam-sodium and its metabolite MITC”, Anal Letters 34
(2001)
10.
Avramescu A, Andreescu S, Bala C, Noguer T, Magearu V, Marty J-L. ” The
potential of screen-printed electrodes for the development of biosensors. Application in
environmental and food industry”, University Politehnica of Bucharest Scientific Bulletin,
Series B, 63 (3), 317-328 (2001)
11.
Avramescu A, Rouillon R, Carpentier R. ”Potential for use of a cyanobacterium
Synechocystis sp. Immobilized in poly(vinyl alcohol): application to the detection of
pollutants”, Biotechnol. Techniques 13, 559-562 (1999).
12.
Aboul-Enein H Y, Al-Duraibi I A, Stefan R-I, Radoi C, Avramescu A. “Analysis
of L- and D-ascorbic acid in fruits and fruit drinks by HPLC”, Sem Food Anal 4 (1), 31-37
(1999)
13.
Dumitrescu V, Avramescu A, Avramescu M. “Potentiometric determination of
lead in wines“, Revista de Chimie, Bucharest 48, 965-974 (1997)
14.
Avramescu M, Varga M, Avramescu A “Research on the peroxidase activity of
grapes from Valea Calugareasca vineyard“, Anale ICVV, Valea Calugareasca, Romania,
15, 385-394 (1996)
POSTER PRESENTATIONS
1.
Lu J, Horga R, Vasilescu A, Feng M, Boratynski J, Jiang W, Qu A, Desai J,
“Investigation of Unknown Compound in Ophthalmic Product R in LDPE Bottles”, AAPS
Annual Meeting and Exposition , Nashville, Tennessee, November 5-10, 2005
2.
Vasilescu A, Andreescu S, Bala C, Litescu S C, Magearu V, Marty J-L,” Screenprinted electrodes with electropolymerized Meldola Blue as versatile detectors in
biosensors”, 7th World Congress on Biosensors, Kyoto, Japan, May 15-17, 2002
3.
Avramescu A, Noguer T, Avramescu M, Magearu V, Marty J-L, “Enzyme sensors
based on screen-printed electrodes and NAD-depndent dehydrogenases. Application to
wine analysis”, 7th international Symposium on Kinetics in Analytical Chemistry,
Bucharest, Romania, September 26-29, 2001
4.
Avramescu A, Noguer T, Avramescu M, Marty J-L “ Screen-printed biosensors for
the control of wine quality”, In Vino Analytica Scientia, Bordeaux, France, June 13-16,
2001.
5.
Noguer T, Vasilescu A, Marty J-L, Fontana-Tachon A, Ghommidh,”Detection of
acetaldehyde with biosensors: amperometry or chronoamperometry”, AGORAL, France,
March 23-26, 2001
6.
Avramescu A, Magearu V, Marty J-L, “ Disposable screen-printed electrodes for
the detection of substrates using NAD+ dependent dehydrogenases”, The Sixth World
Congress on Biosensors, San Diego, USA, May 24-26 , 2000
7.
Avramescu A, Avramescu M, Magearu V, Marty J-L. “Determinarea D-lactattului
din vinuri cu ajutorul senzorilor de unica folosinta“, Sesiunea Stiintifica Anuala ICVV
Valea Calugaresca, Romania, 4-6 iulie 2000
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ALINA M. VASILESCU - Page 4 of 4
8.
Avramescu M, Avramescu A “Recherche sur les activites peroxidasiques des
raisins dans le terroir viticole Valea Calugareasca”, Conference “Les Terroirs Viticoles”,
Angers (France), June 17-18, 1996
BOOK CHAPTER
Vasilescu A, Bala C, “Biosensors based on dehydrogenases” in “Biosensors. Applications
and perspectives”, (2003) Ed. ArsDocendi
ORAL PRESENTATIONS
1.
Noguer T, Avramescu-Vasilescu A, Calas-Blanchard C, Marty J-L. “Enzyme
sensors for NAD+-dependent dehydrogenases”, Second France-Israel Workshop on
Bioanalytical sensors, Biochips and Nanobiotechnologies, Autrans, France, December 1116, 2000.
2.
Avramescu A, Magearu V, Marty J-L. “A disposable screen-printed sensor for
NADH and its application to developing a biosensor for D-lactate”, 5-eme Rencontre
Transfrontaliere Capteurs et Biocapteurs, Vic, Spain, September 21-22, 2000
3.
Avramescu A, Magearu V, Marty J-L. “Screen-printed biosensors for the detection
of D-lactate in wines”, University of Bucharest, Romania, July 2nd, 2000
4.
Avramescu A, Magearu V, Marty J-L. “Strategies in biosenosrs based on NAD+dependent dehydrogenases. Application for D-lactate analysis”, 4-eme Rencontre
Transfrontaliere Capteurs et Biocapteurs, Montpellier, France, September 14-16, 1999
5.
Avramescu A, Rouillon R, Marty J-L. “Potentilites des deux especes des
cyanobacteries utilisees comme element sensible dans un biocapteur”, 7th National
Colloquim of French Electrochemistry Group, Ceret, France, March 29-31
6.
Avramescu A. “ Analiza unor vinuri de la Valea Calugareasca cu exemplificare la
determinarea ionului Pb 2+ “, Student Scientific Session dedicated to the Tricentennial of
University of Bucharest, Romania, 1994
PARTICIPATION IN RESEARCH PROJECTS

Romanian research program “MATNANTECH”, 2001-2003, “Intelligent
Microsystem based on Enzyme Biosensors for Rapid Wine Control”, Project director: C.
Bala, University of Bucharest

Romanian research program “ BIOTECH”, 2001-2003, “Integrated System for
Monitoring Malo-lactic Fermentation of Wines”, Project director M. Avramescu, ICDVV
Valea Calugareasca
OTHERS
 Dual citizenship: Romanian/Canadian
 Foreign languages: English and French (fluent)
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