Program - 1st ESSDV - Dinard - 01-04 March, 2017.
Wednesday March 01
Wednesday afternoon:
14:00 - 18:00
Welcome, meeting registration, accommodation.
Wednesday evening:
18:00 - 18:30
Opening session by the organizing committee members.
18:30 - 19:00
Elim Man, Great Ormond Street DSD MDT & John C Achermann. A Single Centre
Experience of Differences/Disorders in Sex Development (DSD) over 20 years.
19:00 - 19:30
Isabelle Stévant, Yasmine Neirijnck, Lee Smith, Manolis Dermitzakis & Serge Nef.
Revisiting cell lineage specification during male sex determination with single-cell
RNA sequencing.
19:30 - 20:00
Manfred Schartl, Susanne Kneitz, Alvaro Roco, Verena A. Kottler, Jennifer Anderson,
Susanne Schories, Indrajit Nanda, Michael Schmid, Jean-Nicolas Volff, Catherine Wilson,
Boudjema Imarazene, Qiaowei Pan, Ming Wen, Amaury Herpin, John H. Postlethwait &
Yann Guiguen. Evolution of sex determining genes in fish.
Dinner (20:30)
Thursday March 02
Breakfast (07:00 - 09:00)
Thursday morning:
09:00 - 09:30
E. Lecluze, A.D. Rolland, M. Ben Maamar, I. Coiffec, P. Filis, P.A. Fowler, S. Mazaud-Guittot,
B. Jégou & F. Chalmel. Dynamics of the transcriptional landscape during human fetal
gonad differentiation and development.
09:30 - 09:50
Ignacio del Valle, Federica Buonocore, Andy Duncan, Lin Lin, Mike Hubank, Martino
Barenco, Dianne Gerrelli & John Achermann. A genomic atlas of human adrenal and
gonad development.
09:50 - 10:10
Ivan Domènech Mercadé, Monika Meyer-Böni & Anna Biason-Lauber. Characterization of
AKR1C2: New Insights into the backdoor pathway for dihydrotestosterone
biosynthesis and implications for Disorders/Differences of Sex Development (DSD).
10:10 - 10:30
Caroline Eozenou, Leila Fusee, Ines Mazen, Ken McElreavey & Anu Bashamboo. A
mutation in WT1 (Wilms' tumor suppressor 1) associated with 46,XX TDSD.
Break (10:30 - 11:00)
11:00 - 11:30
Anu Bashamboo, Caroline Eozenou, Joelle Bignon-Topalovic & Ken McElreavey. Exome
sequencing identifies new genes involved in human sex-determination.
11:30 - 11:50
Patrick Sproll, Wassim Eid, Camila R Gomes, Berenice B Mendonca, Elaine MF Costa &
Anna Biason-Lauber. CBX2.2 mutation as novel cause for 46,XY Disorder of Sex
Development.
11:50 - 12:10
Anu Bashamboo, Caroline Eozenou, Joelle Bignon-Topalovic, Diana Lourenco, Sandra Rojo
& Ken McElreavey. 46,XY DSD caused by a de novo missense mutation in the TALE
homedomain of PBX1.
12:10 - 12:30
Federica Buonocore, Peter Kühnen, Jenifer P Suntharalingham, Ignacio Del Valle, Martin
Digweed, Harald Stachelscheid, Noushafarin Khajavi, Mohammed Didi, Angela F Brady,
Oliver Blankenstein, Annie M Procter, Paul Dimitri, Jerry K H Wales, Paolo Ghirri, Dieter
Knöbl, Brigitte Strahm, Miriam Erlacher, Wei Chen, Glenn Anderson, Deborah Morrogh, Dale
A Moulding, Shane A McKee, Charlotte M. Niemeyer, Annette Grüters & John C Achermann.
Gain of function variants in SAMD9 cause a complex multisystem condition with
dynamic genomic rescue.
Lunch (12:30 - 14:00)
Thursday afternoon:
14:00 - 14:30
Silvana Guioli, Debiao Zhao, Michael Clinton & Robin Lovell-Badge. Early morphogenesis
of the chicken ovarian cortex.
14:30 - 14:50
Nathalie Daniel-Carlier, Erwana Harscoët, Laurent Boulanger, Nathalie Daniel, Eric Pailhoux
& Geneviève Jolivet. The rabbit as a model for the study of genes involved in the
mechanisms of sex differentiation : phenotype of the aromatase knockout (ArKO)
rabbit.
14:50 - 15:10
Anne-Amandine Chassot, Morgane Le Rolle, Sarah Elkeurti, Virginie Magnone, Alexandra
Popa, Agnès Paquet, Pascal Barbry & Marie-Christine Chaboissier. Transcriptomic
signature accompanying the sexual change fate of XX gonad caused by Rspo1 lossof-function.
15:10 - 15:30
Clara Gobé, Nathalie Daniel-Carlier, Marjolaine André, Dominique Thépot, Geneviève
Jolivet, Eric Pailhoux & Maëlle Pannetier. Long range regulation of FOXL2 expression by
epigenome editing.
Break (15:30 - 16:00)
16:00 - 16:30
Frédéric Veyrunes. Sex reversal and polygenic sex determination in the African pygmy
mouse, Mus minutoides.
16:30 - 16:50
Catherine Livermore, Nick Warr, Madeleine Pope, Gwenn Carré & Andy Greenfield. A
genetic modifier of B6.YPOS sex reversal.
16:50 - 17:10
Nitzan Gonen, Helen O’Neill, Danielle Maatouk & Robin Lovell-Badge. Studying longdistance enhancers of Sox9 in the developing mouse gonad.
Short break (17:10 - 17:30)
17:30 - 17:50
Gwenn-Aël Carré, Pam Siggers, Marilena Xipolita & Andy Greenfield. Conditional deletion
of p300/Cbp in embryonic gonadal somatic cell induces XY gonadal sex reversal.
17:50 - 18:10
Moïra Rossitto, Florence Cammas, Brigitte Boizet-Bonhoure & Francis Poulat. Role of
Trim28 in supporting cells fate.
18:10 - 18:30
Lichilín Nicolás, Fucile Geoffrey, Sengstag Thierry, Salzburger Walter, Böhne Astrid.
Occurrence and evolution of six sexual development genes in Lake Tanganyika cichlid
species.
Dinner (20:00)
Friday March 03
Breakfast (07:00 - 09:00)
Friday morning:
09:00 - 09:30
Alicia Hurtado, Francisco Barrionuevo, Gwang-Jin Kim, Rogelio Palomino, Francisca M.
Real, Francisco D. Carmona, Gerd Scherer, Miguel Burgos & Rafael Jiménez. Sox9 and
Sox8 control Dmrt1 to maintain the adult testis phenotype.
09:30 - 09:50
Elodie P. Gregoire, Isabelle Stévant, Anne-Amandine Chassot, Luc Martin, Serge Nef &
Marie-Christine Chaboissier. NRG1 signalling is involved in testis development in mice.
09:50 - 10:10
Pierre Calvel, Yasmine Neirijnck, Françoise Kuhne, Karen Kilcoyne, Isabelle Stévant, JeanLuc Pitetti, Richard Griffeth, François Pralong, Lee Smith & Serge Nef. Insulin and IGF1
receptors are required for Leydig cell differentiation and function in mice.
10:10 - 10:30
Aitana Perea-Gomez, Kathryn McClelland, Furong Tang, Fei Zhao, Heather Franco, Mireille
Vasseur-Cognet, Marie-Christine Chaboissier & Humphrey H-C Yao. NR2F2 is required for
steroidogenic cell development in the fetal mouse testis.
Break (10:30 - 11:00)
11:00 - 11:30
Sylvain Bertho, Amaury Herpin, Elodie Jouanno, Ayaka Yano, Thomas Muller, Barbara Nicol,
Maëlle Pannetier, Eric Pailhoux, Manfred Schartl & Yann Guiguen. "SdY", the bizarre
master sex determinant of salmonids, triggers its action by directly hijacking the
conserved gonadal differentiation pathway.
11:30 - 11:50
Manfred Schartl, Susanne Schories, Yuko Wakamatsu, Isashi Hashimoto, Cornelia Schmidt,
Dagmar Wilhelm, Lazzaro Centanin, Yann Guiguen & Amaury Herpin. Insertion of a
transposable element rewires transcriptional regulation of a novel sex-determining
gene.
11:50 - 12:10
Qiaowei Pan, Ayaka Yano, Jennifer Anderson, Julien Bobe, Elodie Dupin de Beyssat, Estelle
Vigouroux, Aline Hug, Hugues Parrinello, Laurent Journot, John Postlethwait, Manfred
Schartl, Christophe Klopp, Amaury Herpin & Yann Guiguen. Identification of the master
sex determining gene in Northern pike (Esox lucius, Esociformes, Teleosts) and the
dynamic evolution of sex determination system within Esociformes.
12:10 - 12:30
Manuel A. Merlo, María Esther Rodríguez, Silvia Portela-Bens, Emilio García, Aglaya GarcíaAngulo, Alberto arias, Ismael Cross & Laureana Rebordinos. Characterization of genes
and chromosomes related to sex determination in Solea senegalensis.
Lunch (12:30 - 14:00)
Friday afternoon:
14:00 - 14:30
Jean-François Baroiller & Helena D’Cotta. Frequency, mechanisms, and consequences
of sex reversal in gonochoristic fish: a review.
14:30 - 14:50
Astrid Böhne. Conservation, Recycling or Novelty? Sex determination in East African
cichlid fishes.
14:50 - 15:10
Rokyatou Sissao, Titus Chemandwa Ndiwa, Arnaud Gagnieu, India Oliveira, Jean-François
Baroiller, Etienne Bezault, Jean-François Agnèse, Aboubacar Toguyeni, Dorothy Nyingi &
Helena D’Cotta. Mismatch between phenotypic and genotypic sex in wild Nile tilapia
fish.
Break (15:10 - 15:40)
15:40 - 16:10
Alvaro S. Roco, Amparo Castillo, Lyle Zimmerman, Tosikazu Amano, Allen Olmstead &
Monica Bullejos. Sex chromosomes and sex determining system in Xenopus tropicalis.
16:10 - 16:30
Boudjema Imarazene, Amaury Herpin, Jennifer Anderson, John H. Postlethwait, Manfred
Schartl, Sylvie Retaux & Yann Guiguen. Micro-evolution of sex determination
mechanisms and sex determining genes in the cavefish Astyanax mexicanus.
16:30 - 16:50
Ming Wen, Qiaowei Pan, Justine Guguin, Elodie Jouanno, Amaury Herpin, Jennifer
Anderson, John H. Postlethwait, Manfred Schartl & Yann Guiguen. Sex determination in
the goldfish, Carassius auratus.
Short break (16:50 - 17:10)
17:10 - 17:40
Moïra Rossitto, Alain Pruvost, Candice Marchive, Aurélie Ghettas, Francis Poulat, Pascal
Philibert & Brigitte Boizet-Bonhoure. Prostaglandins, NSAIDs and paracetamol and
development of the urogenital tract.
17:40 - 18:00
Alicia Hurtado, Rogelio Palomino, Francisca M. Real, Francisco D. Carmona, Miguel Burgos,
Rafael Jiménez & Francisco Barrionuevo. Both Sertoli cell-specific Mirc1 mouse mutants
and Mirc3 null mutants show altered spermatogenesis-related testicular
transcriptomes.
18:00 - 19:00
Conclusion of the symposium - First results of the survey trying to answer
the question : what's the future for ESSDV?
Dinner of the Symposium (20:00)
Saturday March 04
Breakfast (07:00 - 09:00)
09:00 - 10:00 ....Conclusion of the symposium, ESSDV-II (if needed, to be discussed on
Friday)!