References
Russel, AD, Path, FR, Hugo, WB, “Antimicrobial Activity and Action of Silver,” Prog Med Chem, 1994; 31:352.
Goetz, A. Tracy, RL, Harris, FS, “The Oligodynamic Effect of Silver,” Chapter 16. Silver in Industry, Rheinhold Publishing Corporation, NY, 1940; p. 401.
Hippocrates, “On Ulcers,” 400 B.C.E.; translated by Francis Adams, ©1994-2000: http//classics.mit.edu/Browse/browse-Hippocrates.html
4
Cumston, CG, History of Medicine, NY, A.A. Knoff Co., 1926; p. 216.
5
Zhao, G, Stevens, SE, “Multiple Parameters for the Comprehensive Evaluation of the Susceptibility of Escherichia coli to the Silver Ion,” BioMetals, 1998; 11:27.
6
Office of Communications and Public Liaison, “Fact Sheet: Antimicrobial Resistance,” National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and the Public Health Service,
U.S. Department of Health and Human Services, June 2000.
7
Garret, L, “Antibiotics Effectiveness Shrinking,” The Idaho Statesman, via Newsday wire service, May 13, 1994; p. 3A.
8
DHLTH – Cable Channel 187, Hollywood, FL, Tuesday night, Dec. 2002.
9
Goetz, A. Tracy, RL, Harris, FS, “The Oligodynamic Effect of Silver,” Chapter 16. Silver In Industry, Rheinhold Publishing Corporation, NY, 1940; p. 401-2.
10 The Council On Pharmacy And Chemistry, “Collargol (Crede’s Colloidal Silver) – Reports of The Committee Appointed To Consider The Claims Made Regarding Its Effects: Report on Collargol,” Special Articles, JAMA,
March 13, 1909; LII(11): 867.
11
Dean, W, et al., “Reduction of Viral Load in AIDS Patients with Intravenous Mild Silver Protein – Three Case Reports,” Clinical Practice of Alternative Medicine, Spring, 2001.
12
Edwards,-Jones, V, Foster, HA, “Effects of Silver Sulphadiazine on the Production of Exoproteins by Staphylococcus aureus,” J Med Microbiol, Jan 2002; 51(1):50-5.
13
Bragg, PD, Rainnie, DJ, “The Effect of Silver Ions on the Respiratory Chain of Escherichia coli,” Can J Microbiol, 1974;20:883-9.
14
Cope FW. Pathology of structured water and associated cations in cells (ther tissue damage syndrome and its medical treatment. Physiol Chem Phys. 1977;9(6):547-53.
15
Cope FW. Magnetoelectric charge states of matter-energy. A second approximation. Part VII. Diffuse relativistic superconductive plasma. Measurable and non-measurable physical manifestations. Kirlian photography. Laser
phenomena. Cosmic effects on chemical and biological systems. Physiol Chem Phys.
16
Lehninger AL. Biochemistry: The Molecular Basis of Cell Structure and Function, 2nd edition. Worth Publishers, Inc., New York, NY, 1978, p. 913-4.
17
Vojdani A. et al., Minimizing cancer risks using molecular techniques: A review. Toxicology and Industrial Health, 1997;13(5):589-626.
18
Pollack GH. Cells, Gels and the Engines of Life: A New, Unifying Approach to Cell Function. Ebner and Sons, Seattle, WA. 2001.
19
Hiemenz, PC, Principles of Colloid and Surface Chemistry, Marcel Dekker, Inc., NY, 1977; p. 210-5.
20 Cope FW. Successful therapy of heart disease by high potassium together with low sodium in accord with predictions from the associated cation, structured water concept of the cell. Physiol Chem Phys 1979;11(1):93-4.
21
Ling GN.An updated and further developed theory and evidence for the close-contact, one-on-one association of nearly all cell K+ with beta- and gamma-carboxyl groups of intracellular proteins. Physiol Chem Phys Med
NMR. 2005;37(1):1-63.
22
Thurman RB, Gerba CP. The Molecular Mechanisms of Copper and Silver Ion Disinfection of Bacteria and Viruses. CRC Critical Reviews in Environmental Control, 1989;18(4):302.
23
Van Gils, C, Stark L, Forbes B. The combined benefit of negative pressure therapy, elemental silver contact layer and bilayered living skin equivalent in the treatment of chronic hard to heal lower extremity wounds. Presented at
Symposium on Advanced Wound Care April 27-30, 2002 Baltimore MD.
24
Becker RO. Induced Dedifferentiation: A Possible Alternative to Embryonic Stem Cell Transplants. NeuroRehabilitation, 2002;17(1):23-31.
25
Eichorn, GL, et al., “Interaction of Metal Ions with Biological Systems, with Special Reference to Silver and Gold,” Proceedings of the First International Conference on Gold and Silver In Medicine, Bethesda, MD, May
13-14, published by The Silver Institute, Washington, D.C., 1987; p. 4.
26
Bodansky, M, Introduction to Physiological Chemistry, John Wiley & Sons, Inc., NY, 1934; p. 22-3.
27
Bechhold, H, Colloids in Biology and Medicine, translated by Bullowa, JGM, D. Van Nostrand Co., NY, 1919; p. 13, 366 & 368.
28
Hartman, RJ, Colloid Chemistry, Houghton Mifflin Co., The Riverside Press, Cambridge, MA, 1939; p. 13.
29
Russel, AD, Path, FR, Hugo, WB, “Antimicrobial Activity and Action of Silver,” Prog Med Chem, 1994; 31:352.
30
Cliver, DO, et al., “Biocidal Effects of Silver: Contract NAS 9-9300 Final Technical Report,” University of Wisconsin, February 1970; p. 5.
31
In vitro investigations published on letterheads from Departments of Microbiology, Pathology, Infectious Diseases, Immunology, Biology, Etc…, from such universities as Johns Hopkins, Northwestern Univ. Medical School,
Queen’s University, University of Arkansas for Medical Sciences, Georgetown University Medical Center, NYU Medical Center, University of Nebraska, University of Massachusetts, etc…circa 1996-1998.
32
Acel, D, Biochem. Z., 1920; 112:23-32. In: Russel, AD, Path, FR, Hugo, WB, “Antimicrobial Activity and Action of Silver,” Prog Med Chem, 1994; 31:353.
33
Eichorn, GL
34
Hill, WR, Pillsbury, DM, Argyria: The Pharmacology of Silver, The Williams & Wilkins Co., Baltimore, 1939; p. 169.
35
Feng, QL, et al., “A Mechanistic Study of the Antibacterial Effect of Silver Ions on Escherechia coli and Staphylococcus aureus,” J Biomed Master Res, 2000 March; 52;662-8.
36
The Council on Pharmacy and Chemistry, New and Nonofficial Remedies, The American Medical Association, Chicago, 1932; p. 403.
37
Pilcher, JD, Sollmann, T, “Organic, Protein and Colloidal Silver Compounds: Their Antiseptic Efficiency and Silver-Ion Content As A Basis For Their Classification,” Journal Laboratory and Clinical Medicine, 1923; 8:306-7.
38
Goetz, A. Tracy, RL, Harris, FS, “The Oligodynamic Effect of Silver,” Chapter 16. In: Silver in Industry, edited by L. Addicks, Rheinhold Publishing Corp., NY, 1940; p. 403.
39
Handbook of Chemistry and Physics, ed. David R. Lide, CRC Press, Boca Raton, Fl., 2000; Section 4, p. 27.
40
Agency for Toxic Substances and Disease Registry (ATSDR), Toxicological Profile for Silver- CAS# 7440-22-4, December 1990.
41
Environmental Protection Agency IRIS CASRN# 7440-22-04, 1996.
42
Goetz, A. Tracy, RL, Harris, FS, “The Oligodynamic Effect of Silver,” Chapter 16. In: Silver in Industry, edited by L. Addicks, Rheinhold Publishing Corp., NY, 1940; p. 403.
43
Handbook of Chemistry and Physics, ed. David R. Lide, CRC Press, Boca Raton, Fl., 2000; Section 4, p.27.
44
Grier, N, “Silver and Its Compounds,” p. 386-90; In: Disinfection, Sterilization and Preservation, S. Block, edit., Lea Febiger, Philadelphia, PA, 1983.
45
Addicks, L, Silver in Industry, Rheinhold Publishing Corp., NY, 1940; p. 403.
46
Bland, J, New Perspectives in Nutritional Therapies: Improving Patient Outcomes, HealthComm, Gig Harbor, WA, 1996, Chapter 2, p. 12 & 25.
47
Morrison, DC, et al., “The Effects of Bacterial Endotoxins on Host Mediation Systems,” American Journal of Pathology 1978; 93:526.
48
Edwards-Jones, V, Foster, HA, “Effects of Silver Sulphadiazine on the Production of Exoproteins by Staphylococcus aureus,” J Med Microbiol, Jan 2002; 51(1):50-5.
49
Pybus, PK, “The Herxheimer Reaction History,” Townsend Letter for Doctors, 911 Tyler St., Port Townsend, WA 98368-6541, May 1991, p. 370.
NATURAL-IMMUNOGENICS CORP.
1
2
Sovereign Immune DefenseTM
3
References from page 2
1
Flavin D. Reversing Splenomegalies in Epstein Barr Virus Infected Children: Mechanisms of Toxicity in Viral Diseases. Journal of Orthomolecular Medicine, 2006 Second Quarter;21(2):95-101.
2
Clerici M, Shearer GM. A TH1-->TH2 switch is a critical step in the etiology of HIV infection. Immunol Today. 1993 Mar;14(3):107–111.
3
Katakai T, et al. Chemokine-independent Preference for T-helper-1 Cells in Transendothelial Migration. J. Biol. Chem., Vol. 277, Issue 52, 50948-50958, December 27, 2002.
4
Foster HD. What Really Causes AIDS? Trafford Publishing, Victoria, British Columbia, Canada, 2002.
5
Wardman P, Candeias LP. Fenton chemistry: an introduction. Radiat. Res. 1996;147:523-531.
6
Saran M, Beck-Speier I, Fellerhoff B, Bauer G. Phagocytic killing of microorganisms by radical processes: consequences of the reaction of hydroxyl radicals with chloride yielding chlorine atoms. Free Radical Biol. Med. 1999;26:482-490.
7
Jansson, G, Harms-Ringdahl, M, “Stimulating Effects of Mercuris- and Silver Ions on the Superoxide Anion Production in Human Polymorphonuclear Leukocytes,” Free Radic Res commun, 1993; 18(2):87-98.
8
Shapiro MP, Setlow B, Setlow P. Killing of Bacillus subtilis spores by a modified Fenton Reagent containing CuCl2 and Ascorbic Acid. Applied and Environmental Microbiology, 2004 April;70(4):2535-2539.
9
Park S, Imlay JA. High levels of intracellular cysteine promote oxidative DNA damage by driving the Fenton reaction. J. Bacteriol. 2003;185:1942-1950.
10
Cross, JB, et al. Killing of Bacillus spores by aqueous dissolved oxygen, ascorbic acid, and copper ions. Appl. Environ. Microbiol. 2003;69:2245-2252.
11
Kawamura F, Hirashima N, Furuno T, Nakanishi M. Effects of 2-methyl-1,4-naphtoquinone (menadione) on cellular signaling in RBL-2H3 cells. Biol Pharm Bull. 2006 Apr;29(4):605-7.
12
Flavin D. Reversing Splenomegalies in Epstein Barr Virus Infected Children: Mechanisms of Toxicity in Viral Diseases. Journal of Orthomolecular Medicine, 2006 Second Quarter;21(2):95-101.
13
Kamath AB, et al. Antigens in tea-beverage prime human Vγ2Vγ2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. Proc Natl Acad Sci U S A. 2003 May 13; 100(10): 6009–6014.
14
Massimo D, et al. Neutrophil Restraint by Green Tea: Inhibition of Inflammation, Associated Angiogenesis, and Pulmonary Fibrosis The Journal of Immunology, 2003, 170: 4335-4341.
15
Gosset P, et al. Thiol regulation of the production of TNF-alpha, IL-6 and IL-8 by human alveolar macrophages. Eur Respir J. 1999 Jul;14(1):98-105.
IMMUNE
OFFENSIVE
WBC Re-engagement
● Superoxide Modulation
● Oxidation Reduction
Potential
● Immune Toxicity
Detoxication
● Pre-emptive Immune
Modulation
●
ARGENTYN 23
Uniform Picoscalar Bio-Active Silver Hydrosol (UPBASH )
TM
PARTICLE SIZE
At an average of 0.0008 microns (0.8 nm), our unprecedented
particle size allows for greater surface area, greater absorption
and greater excretion.
PARTICLE ENERGY
Our exclusive Bio-ActivationTM process produces
96% active silver particles, held in suspension
solely by their positive ionic charge.
23
ppm
23
ppm
23
ppm
CONCENTRATION
Because of greater potency, we
23
only need to utilize a safe 23 ppm
ppm
23
concentration,
which is optimal
ppm
for daily professional use.
SAFETY
Argentyn 23TM can be taken
safely 3x a day for 70 years
and still not exceed EPA
RfD guidelines (see pg. 6).
Sovereign Immune DefenseTM
Manufactured by Natural-Immunogenics Corp., USA. For more information, call: 1.888.328.8840 (USA & Canada only),
+1.954.979.0885 (Int’l), +1.954.979.0838 (Fax) or visit: www.natural-immunogenics.com
ARGENTYN 23
TM
Argentyn 23TM is the world’s only Professional Bio-ActiveTM Silver
Hydrosol. Our Silver Hydrosol makes all other professional
formulations obsolete.
NATURAL-IMMUNOGENICS CORP.
© 2006 Natural-Immunogenics Corp.
™
™
Professional Silver Hydrosol Formulation
PURITY
Only Argentyn 23TM
uses ultra-pure medicalgrade water in glass
bottles to eliminate
contaminants that
render other silver
products inactive.
The History, The Problem, The Solution
A Brief History
Since ancient times silver has been highly regarded as a premier
preservative and immune tool.1 In ancient Greece, Rome, Phoenicia
and Macedonia, silver was used extensively to help control many
immune challenges.2 Hippocrates himself, the “Father of Medicine,”
used silver and taught that it promoted tissue repair. For example,
he spoke of it as a notable topical aid.3 In 69 B.C. silver nitrate was
described in the contemporary pharmacopoeia.4
Two thousand years later (1897) silver nitrate began to be widely
used in America. The result was an enormous alleviation of certain
risks to the eyes of newborns.5 Just prior to this, a discovery occurred
that would give lasting purpose to the entire spectrum of silver
based aids. This pivotal discovery was to become known as silver’s
oligodynamic power.
FACTS
The Problem: Defiant Immune Challenges
Physicians are being confounded by emerging trends that defy nearly
all immune protocols. Even as new products and protocols suggest
success, sooner or later the success proves illusory. The Institute
of Medicine, under the National Academy of Sciences, estimates
that the annual cost associated with these difficult situations may
be as high as $30 billion. In 1994, the Center for Disease Control
viewed this emerging trend as America’s number one health issue.
Annually, over 2 million Americans may present these highest risk
immune challenges to their physician.6,7,8 Simply stated, this trend
is unacceptable. Perhaps rethinking this problem necessitates a fresh,
out-of-the-box approach. Perhaps it is time for arming your practice
with an immune offensive protocol starting with Argentyn 23™.
The Solution: Multi-Functional Immune Modulation
Karl Nägeli (1893) first coined the term “oligodynamic
effect” (from the Greek oligos = few, and dynamis =
power) to best describe how very potent and
meaningful biological actions are exerted by
extremely low metal ion (e.g., silver and copper ion)
concentrations.9 Oligodynamic Ag+ has been shown
to modulate events which are immune offensives,10,11
such as promoting superoxide release, supporting
healthy regulation of toxicants,12 and promoting healthy
enzyme mediation from exogenous sources.‡13 Through
these supportive mechanisms and others, Argentyn 23TM
offers excellent support for immune health.‡
Conclusions
Oligodynamic silver (Ag+) clearly has a significant role
to play within the normal diet. By virtue of its content
in Argentyn 23TM, health care providers now have an
excellent opportunity for a variety of effective and highly
strategic immune enhancing protocols.‡
Argentyn 23™’s Oligodynamic Ag+ Content May
Promote Strategic Immune Enhancements‡
Free Radic Res Commun, 1993; 18:87-98
Stimulating Effects of Mercuric- and Silver Ions
on the Superoxide Anion Production in Human
Polymorphonuclear Leukocytes.
Jansson, G, Harms-Ringdahl, M
Thurman and Gerba
surmised as early as 1989
that oligodynamic silver
ions mediate extracellular
and intracellular immune
challenges. Lund concluded
that these tactical benefits
were attributable to the
oxidation potential of
the ion. Targets may be
enzymes, proteins within
membranes or nucleic
acids. Berger, et al.,
found oligodynamic
Ag+ to be either
beneficial, harmless
or of negligible toxicity
to mammalian tissues.
> > > >Immune Offensive
> Argentyn 23TM may promote WBC surveillance‡
> Helps modulate the superoxide-mediated immune response‡
Three Steps to Restoring Optimal Immunity
Many sudden onset or long duration immune assaults induce a severe increase
in three related inflammatory agents, namely (1) tumor necrosis factor-alpha
(TNF-α), (2) xanthine oxidase (XO), and (3) nitric oxide (NO). All three
collude into a rogue cascade highly detrimental to immune function. At play
within this detrimental cascade is an alarming escalation in peroxynitrite
production, perhaps the most toxic of all free-radicals generated by the
human body. When this collusion occurs, two potentially devastating
immune events are induced. First, there will be accelerated self-destruction
Silver Enhancing WBC Re-Engagement
of vital immune cells.1 And second, the hallmark of optimal immunity
undergoes progressive inversion, namely the favorable Th-1 immune cell
dominance shifts to an unfavorable Th-2 immune cell dominance2 with a
resulting downregulation of Interferon-gamma (IFN-γ).3 The latter favors
autoimmune dysregulation and furthers self-destruction. Compounding this
self-destruction is a localized or systemic “theft” and depletion of a critical
family of antioxidants within immune and somatic cells, most importantly
glutathione peroxidase (GSH-Px).4
What is needed most is a strategy that halts the excessive XO, NO, TNF-α
production while simultaneously upregulating the GSH-Px and IFN-γ
levels to optimal levels. This would lead to an
immediate shift back to Th-1 dominance. Such
a strategy would simultaneously contain and
deny the downstream production of peroxynitrite.
However, the quintessential restoration of optimal
immune reserves of endogenous hydrogen
peroxide (H2O2) and hydroxyl radical (OH-)
requires providing adequate metal catalysts such
as silver, copper, iron, zinc and selenium. In this
fashion, even the most severe immune challenges
simply fizzle into oblivion.
Oxygen
Superoxide
Respiratory Burst
Silver Ion
2
Copper Ion
Copyright© 2006 Nucleus Medical Art, All rights reserved. [1] Jones OT. The mechanism of the production of superoxide by
phagocytes. Mol Chem Neuropathol. 1993 May-Jun;19(1-2):177-84
The Emerging Science of Underlying Mechanisms
to Severe Immune Challenges & Assaults
Three steps to returning optimal immunity
from devastating chronic immune suppression:
Life is a Function of the Colloidal State
The primary chemistry of all living
processes occurs in the colloidal state
through molecules that are “suspended”
as opposed to being “dissolved” in bodily
fluids. Colloidal fluids enable optimal electron “poising” and
transfer (redox), plus optimal stereo-chemical molecular alignments,
interfaces and re-arrangements.14 The “suspension milieu” of the
colloidal state greatly lessens the constraints that time and space
ordinarily exert upon essential biochemical pathways.15 For example,
at normal body temperatures, vital biochemical reactions will occur
up to a billion times slower in the absence of functional enzymes.16
To illustrate the near quantum speeds of the living suspension
milieu, consider the following: DNA assays suggest that a healthy twenty-five
year old, well-nourished human will suffer 100,000 genetic mutations daily to
each of his or her 75 trillion human cells. That translates into approximately
7,500,00,000,000,000,000 (7.5 quintillion) genetic injuries daily! Yet within these
same 24 hours, near perfect levels of repair are completed! 17
Essentially, this suspension milieu maximizes life within our cells by insuring dominance over their environment.
➋
Colloidal minerals, such as silver, copper and gold hydrosols, have several critical roles to play applicable to the genesis and
function of the colloidal state. Of particular note, colloidal metals initiate the transformation of bodily liquids from simple
solvents into highly structured, ordered and energy rich gels. Since these gels are stabilized, they tend to be non-reactive with
other molecules, resulting in an array of molecules in suspension.18 As a result, the surface area of the molecule becomes
360° exposed in all directions, optimizing its capacity to react with other suspended molecules.19 Indirectly or directly,
colloidal minerals transition dissolved molecules into their suspended state,20 and vis-à-vis colloidal proteins transition dissolved
minerals into their suspended state.21
➌
Of particular note, colloidal metals serve as catalysts (i.e., oxidases) to vital metabolic redox events.22 As lower life forms
evolved over the millennia into higher life forms, silver appears to have played a quintessential catalytic role in the evolution
of the aerobic mechanisms. This becomes clear when one considers how in higher (but not lower) life forms, silver amplifies
complex immune functions,23 and induces regenerative events even within human tissues.24
➊
Supply the pre-requisites of healthy H2O2
production via the Fenton Reaction by
administering Vitamins B-1 & B-3,
Copper, Iron and cysteine;5,6
Supply the pre-requisites to healthy production
of key beneficial upstream reactive oxygen
intermediates (ROIs) such as H2O2 and OHby administering picoscalar Silver, picoscalar
Copper, cysteine and vitamins C & K;7,8,9,10,11
Supply the pre-requisites for the containment
and elimination of key harmful downstream
radicals such as XO, TNF-α and peroxynitrite
by administering Licorice/Green Tea and
Vitamin B-3 plus NAC and selenium to
induce GSH-Px production.12,13,14,15
‡These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent disease.
Samuni, et al., stated
that the transition metals
(i.e., Cu, Au, and Ag) are
essential for promotion
of superoxide radical
activity. The resulting
redox reactions are site
specific to their targets.
Secondary radicals are
also generated within
the same vicinity of
targets and react as well
without being lost to
diffusion. Recycling these
redox reactions causes
multiple-modulations
at the same target, an
“immune offensive” for
oligodynamic Ag+ of
great import.‡
3
Manufacturing Silver Colloids or Hydrosols
Historical Silver Formulations: During the last century, drug
manufacturers sought to commercially produce oligodynamic silver
formulations in quantity. 20th century manufacturing methods were
technologically handicapped in their efforts to produce purely active
silver. Nevertheless, more than 96 different silver formulas were in
use prior to 1939, as documented by The Council on Pharmacy and
Chemistry of the American Medical Association.34
By 1937, the 3 factors governing the oligodynamic action of silver
were known, but, as just stated, the technology to create commercially viable amounts of charged (active) colloidal particles was not
yet possible. As a result, inferior silver formulations were readily
replaced as immune tools in the era of antibiotics. The oligodynamic
effect was either forgotten or ignored. In a nutshell, it is argued that
the most biologically active (oligodynamic) silver would be
“picoscalar Ag+”, and at low concentrations.35
On the other hand, the inadequate methodologies used to make
those silver formulations supplied large quantities of cheap silver
FACTS
compounds so that under sheer volume, at least some active silver
ions are obliged to break away, such as with:
●
Mild Silver Proteins
●
Strong Silver Proteins
●
Particle Size: One critical characteristic of metal ions, central to their chemical and biological activity, is
size — an important factor in determining whether one metal can replace another in a given environment.25
The smaller the colloidal silver particle, for example, the more biologically active it becomes. Colloidal silver
particles in commercial products of the last century were thought to be 0.014 to 0.026 microns (14 to 26
nanometers). This issue of surface area is of utmost importance. The activity of biocatalysts like colloidal
silver is directly proportional to the adsorption power upon a biological surface.26 Ostwald demonstrated
the geometric progression to the surface area of silver particles by assuming a starting point of 1 cubic
centimeter of silver. Reducing incrementally into smaller and smaller cubes, the silver particles eventually
approach six square kilometers: 27,28
Silver Salt Speciations
For example, Collargol was up to 78% total silver bound within a
protein colloid, of which only 2% or less was oligodynamic (active
Ag+).36 The highest percentage of active silver in a Strong Silver
Protein colloid — a “hybrid” colloid and silver salt — was rated at
only 16.8%.37 In both cases the vast amount of elemental silver is
dead weight.38 Thus, biologically meaningful action of heavy metal
salts is only obtained from a much higher concentration when taken
internally, but at a “caustic” cost. This distinction underscores why
heavy metal salts are considered poisons.39
1.0 cm = 6cm2
1.0 micron = 6m2
1.0 nanometer = 6km2
With the arrival of high-tech silver manufacturing techniques,
physicians now have the opportunity to use a highly effective
oligodynamic silver, one that presents little if any risk. Physicians
are now re-discovering — especially with Argentyn 23TM —
that it is a safe and effective functional mineral supplement.
Argentyn 23™ contains uniform silver particle sizes approximating 8 Ångstroms (Å) or 0.8 nanometers, making
it a true picoscalar dispersion as determined by transmission electron microscopy.
Argentyn 23™ has
completed the
Chromosomal
Aberrations Screening
(CHO Cells) Assay
through Covance
Laboratories, Inc. Results
clearly demonstrated no
toxicity. (Ref: Assay No.
24742-0-437 SC; Study No.
> > > >Silver Particle Size
7417-101.)
> Argentyn 23TM may promote WBC surveillance‡
> Helps modulate the superoxide-mediated immune response‡
Comparing Other Formulations
The laboratory at Natural-Immunogenics, where Argentyn 23TM is made, has evaluated over one-hundred brands of ‘colloidal silver’ to
date. Its library of analyses is undoubtedly the largest such collection ever assembled. The electron microscope that was used to capture the
specimens shown on this page is capable of resolution to 3 Ångstroms (virtually atomic level) at 480,000x magnification. The micrographs
below were all taken at 100,000x.
Argentyn 23TM — 23 ppm
The result of a unique
proprietary process, this
near perfect dispersion
of the tiniest particles
(average 0.8 nm)
ever seen clearly
demonstrates the
considerable energy
imparted to them.
Herbal Healer Academy — 500 ppm
The particulate contents
of this formulation have
no energy at all and tend
to agglomerate within
the organic matrix that
holds them in suspension.
They average from 3 nm
to 12 nm, with a mean
of approximately 8 nm.
4
Argentyn 23™ Particle Size
Silver 50 MSP — 50 ppm
This protein based colloid
is comprised of both inert
silver particles that vary
between 2 nm and 15 nm
possessing no particular
charge. They tend to
flocculate even in the
protein matrix that holds
them. The organic ties up
the balance of silver content
that is not colloidal.
Amino Acid & Botanical Supply — 500 ppm
The particles that would
characterize this product
as a colloid are actually
quite discrete for a protein
formulation. The variable
size particles, from 2 nm
to 8 nm, do not have
much energy and tend
to flocculate.
‡These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent disease.
Silver 400 MSP — 400 ppm
The silver content in this
protein-based colloid
features large and inert
(elemental) particles, some
of them 5 nm to 9 nm.
The broad organic residue
that shows as background
has bound the balance
of the silver, further
diminishing its
biological activity.
ASAP Health Max 30 — 30 ppm
This “colloid” contains
molecular chains and
neutral deposits; particles
ranging from 2 nm to 8 nm.
Additionally, one sees solute
residue that could be
(or could not be) organic.
Argentyn 23™ State of the Art
When looking at colloidal silver, there are
two more issues that need to be understood
— silver concentration and particle charge.
This makes the silver “active”. The various
forms of silver formulations can be divided into five
categories: Silver Salts (i.e., silver nitrate), Strong Silver
Proteins (i.e., hybrid of silver salt formulated with a protein
colloid), Mild Silver Protein (i.e., silver atoms bound to
gelatin or egg protein), Silver Halides (i.e., silver chloride),
Stephen Quinto
Founder
Silver Nucleinates (silver nucleoproteins), and Silver Hydrosol
(i.e., Ag+ and H2O). Except for the last category, active silver content
never exceeded 16.8% of the total elemental silver content (documented
on page 4). With silver hydrosols, this figure may be exceeded. Silver hydrosols may
be made chemically or via electrolysis. Argentyn 23TM is made with a proprietary
electrolysis process yielding over 96% active silver.‡
Silver Concentration: In 1893, Nägeli determined that oligodynamic Ag+ was an effective
biocide at concentrations ranging between 0.0000001% to 0.00006% (equivalent to 9.2 x 10-9 M
to 5.5 x 10-6 M, respectively, or 92 ppb to 55 ppm) in vitro.29
Argentyn 23TM has
also completed the
Ames Confirmatory
Mutagenicity Assay
through Covance
Laboratories, Inc.
Results clearly revealed
no toxicity. (Ref: Assay No.
24742-0-409OECD; Trial No. C1.)
In 1970 NASA sponsored a study confirming Nägeli’s findings in principle that oligodynamic
Ag+ was a highly effective biocide in concentrations of 50 ppb over 4 hours or less, and at
concentrations of 250 ppb over 2 hours or less.30 As advances in understanding occurred, it was determined that
raising the silver ion concentrations to 10 ppm or more reduced the necessary time of exposure to mere minutes.31
Particle Charge: Another obvious characteristic of metals is their charge. Acél was perhaps the first to observe that
the oligodynamic action of silver was due to liberated silver ions (i.e., Ag+).32 The charge significantly facilitates
electron displacement. The oligodynamic metal charge effectively yanks electrons away from a molecule, in essence
weakening the molecular bond and rendering it susceptible to cleavage.33 These charges, which powerfully displace,
also repel like charges — strikingly illustrated to the reader by the transmission electron micrograph on page 4
depicting Argentyn 23TM’s uniform particle dispersion.‡
5
2.2.2.1. Death – No studies located regarding death in humans following oral exposure to silver or silver compounds.
2.2.2.2. Systemic Effects – No studies located regarding respiratory, gastrointestinal, hematological, musculoskeletal, hepatic, or renal effects in humans
or animals after oral exposure to silver or silver compounds.
2.2.2.3. Cardiovascular Effects – No studies were located regarding cardiovascular effects in humans following oral exposure to silver or silver compounds.
2.2.2.4. Dermal/Ocular Effects – Gray or blue-gray discoloration of the skin has been observed in individuals that have ingested both metallic silver and
silver compounds in excess.
2.2.2.5. Immunological Effects – No studies were located regarding immunological effects in humans following oral exposure to silver or silver compounds.
2.2.2.6. Neurological Effects – Several reports describe the deposition of what are assumed to be silver containing granules in tissue of the central nervous system.
2.2.2.7. Developmental Effects – No studies were located regarding developmental effects in humans after oral exposure to silver or silver compounds.
2.2.2.8. Reproductive Effects – No studies were located regarding reproductive effects in humans after oral exposure to silver or silver compounds.
2.2.2.9. Genotoxic Effects – No studies were located regarding genotoxic effects in humans after oral exposure to silver or silver compounds.
2.2.2.10. Cancer – No studies were located regarding cancer effects in humans after oral exposure to silver or silver compounds.
Scope of Acceptable Dosage Ranges: In 1996 the Environmental Protection Agency (EPA) published and established a daily Oral
Reference Dose (RfD) based on a mathematical equation (5 mcg/kg/day).41 The Oral RfD applies to a continuous daily ingestion
that is considered highly unlikely to cause any risk or harm during the entire course of a lifetime.
●
●
3 teaspoons (1 tablespoon) of Argentyn 23TM can be taken everyday for 70 years in accordance with the RfD.
8 teaspoons of Argentyn 23TM can be taken every day, continuously, for 70 years and still not exceed the threshold for the lowest observed adverse
event level (LOAEL), cumulatively pegged (over a lifetime) at 25 grams of silver.
FACTS
>>>>
a.Taking 3 Tablespoons daily of
EPA Lowest Observed Adverse
Argentyn 23TM for 60 years falls
below LOAEL threshold for an adult;
Event Level (LOAEL) 23 PPM
b.Taking 6 Tablespoons daily of
25
Argentyn 23TM for 30 years falls
below LOAEL threshold for an adult;
20
c.Taking 12 Tablespoons daily of
TM
Argentyn 23 for 15 years falls
15
below LOAEL threshold for an adult;
d.Taking 24 Tablespoons daily of
10
Argentyn 23TM for 7.5 years falls
below LOAEL threshold for an adult;
5
e.Taking 48 Tablespoons daily of
Argentyn 23TM for 3.75 years falls
0
below LOAEL threshold for an adult;
10 20 30 40 50 60
f.Taking 256 teaspoons daily of
Years
Argentyn 23TM for 2 years falls
below LOAEL threshold for an adult;
g.Taking 85 Tablespoons daily of
Argentyn 23TM for 2 years falls below LOAEL threshold for an adult;
h. Taking 1/3 gallon daily of Argentyn 23TM for 2 years falls below LOAEL threshold for an adult.
Product Versatility – Risk/Benefit Profile: Goetz stated specifically that, “In view of the practical applications it appears that silver is best suited as
an oligodynamic material because of the extremely slight solubility of most of its salts, which in fact renders it almost impossible for large concentrations of
silver ions to occur in higher organisms. This particular property singles silver out from the host of other oligodynamic metals which may have the same
activity, and renders it practically harmless to animals and humans.” 42 Indeed, silver compounds appear to be the basis of all reports of silver’s toxicity
in higher life forms.43,44,45
In summary, the physicians selecting Argentyn 23
TM
as their preferred oligodynamic (bio-active) Ag+ choice can do so with total confidence.
Jarish-Herxheimer Effects Associated with Immune Detoxication Overload: Jarish-Herxheimer Effects typically have predictable
distributions and patterns of occurrence within test subject populations.46,47 In the case of Argentyn 23TM, a portion of patient populations
receiving the product may experience the associated immune detoxication events listed below.‡48 In order of known frequency, these may
include from the most frequent to the most rare — mild to moderate headaches, arthalgia, hyperdiaphoresis, nausea, afebrile flu-like symptoms,
simple malaise, erythemia, skeletal pain, itching, rigors or chills, diarrhea typically of short duration, vomiting of short duration, fever.49
Associated immune detoxication events that arise when using Argentyn 23TM can be managed by a 24 – 48 hour wash-out period from the
dosage schedule. With careful medical supervision, it is then permissible to return to a dosage equaling just ½ of the initial dose level taken at
the time associated immune detoxication events arose. Classically, such associated immune detoxication events suggest that the targeted immune
burdens are resolving rapidly. Therefore, carefully continue a reduced dosage schedule for 3 – 7 days.
Again, the ½ dosage level is determined by the participant’s “pre-reaction” dosage. Under medical supervision, the reduced schedule is then slowly
increased until the optimal dosage schedule is achieved. Proactive measures should be matched incrementally to any Argentyn 23TM protocol to aid
detoxication functions according to: (1) occurrence, (2) frequency, and (3) intensity of associated immune events.
CAS# 7440-22-2 found
that silver speciations
(i.e., silver cyanide and
silver arsenic versus
simple metallic silver)
express quite different
70
toxicity data. Speciation
is a highly precise term
exclusively concerned
with differentiating
and detailing the fates,
transport mechanisms
and toxicities of
compounds containing
the same metal ingredient.
Product Usage
> Argentyn 23TM’s content of oligodynamic Ag+, modulates a series of immunological events‡
> May enhance detoxication of immune intoxicants associated with exogenous factors‡
Product Cytotoxicity Tests: Argentyn 23™ underwent a murine Acute Oral Toxicity Study (LD50) with Covance Laboratories, Inc.
(ref: 24742-0-800). The result revealed absolutely no harmful affects to mammalian tissue at a dosage of 20mL/kg. While murine tissue
is not identical to human tissue, the test suggests that 1400cc ingested at one time by a 154 lb adult is not medically harmful.
6
Sub-LOAEL Threshold Power Dosages: The EPA’s Lowest Observed Adverse Event Level is based upon the
mathematical formula of 14 mcg/kg/day. Only if the threshold is exceeded is the risk for the medically benign
condition of argyria (a permanent discoloration of the dermis) considered a possible risk.
LOAEL Threshold
Scope of Non-Toxicity: Argentyn 23™ is comprised strictly of picoscalar, charged silver ions and ultra-pure water only. This places Argentyn 23TM
into a category by itself when comparing other silver formulations. For example, in 1990 the Agency for Toxic Substances and Disease
Registry (ATSDR) conducted an exhaustive study (CAS #7440-22-4) on toxicity issues deriving from a wide variety of silver speciations.40
Taken as a whole their collective human oral exposure risks were extremely remote:
Argentyn 23™ Dosage Parameters
Silver in grams
Argentyn 23™ Safety Parameters28
These proactive measures include:
Drinking ½ to 1 ounce of
purified water for each pound
of body weight;
●
Use of hepatic detoxifying
nutraceutical supports
1 to 3 times daily;
●
Dietary measures that include low fat,
low sugar and low meat diets, plus strict
avoidance of all junk foods, fast foods,
and fried foods;
●
Recommendations for high fiber diets while on the program
insuring a minimum of one well-formed B.M. daily;
●
Referral if necessary for a short set of colonic irrigations;
●
One or more organic coffee (or organic green tea) enemas
as needed, which typically offer immediate results;
●
Sitz/saltz baths: Take 1 cup salt, 1 cup soda, 1 cup Epsom salts,
1 cup aloe vera and add into a hot bath, keeping the water hot
for about 1-½ hours, while consuming 2 quarts of fresh-squeezed
organic lemonade.
●
‡These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent disease.
7