Int J Ayu Pharm Chem REVIEW ARTICLE www.ijapc.com e-ISSN 2350-0204 Conceptual Study of Dushi Visha in Present Era w.s.r. to Occupational Hazards and Agricultural Poisons N. S. Gangasagre1, Nilesh Salve2*, Shital Mirajkar3, Subhashini Lahankar4 and Ravindra Pandhare5 1-5 Department Agadtantra Dept, GAC Osmanabad, Maharashtra, India Abstract Ayurveda gives more importance to prevention of disease and maintenance of health. As given in ayurvedic classic text, a poison is a substance which vitiate normal functioning of dosh, dhatu, mala. Thousands of harmful toxins are present in atmosphere that are ingested by the human beings on daily basis. As described in our Samhita Granthas, Dushivisha is an intake of toxic drugs which is less potent and remains in dormant state within the body for year together without causing any major harm to body. As we see in today's era workers working in lead industry like enamel workers, glass blowers, printing works has typical chronic lead poisoning symptoms such as constipation, tremors, menstrual disarrangements etc due to chronic exposure to lead which accumulates in body and produces its ill effect like Dushivisha. Arsenic, copper, mercury chronic occupational poisoning also happened due to long exposure of poison working in respective industry. In agriculture, the chronic exposure to OPP, OCP, weed killers like parquet, chlorophenoxyacetates, chlorates used to prevent infection in plants, being sprayed by farmers on daily basis, leads to symptoms like dysphasia, oropharyngial ulcers, coughing, pain in abdomen, etc. These symptoms resemble to Dushivisha like symptoms. From this article, we may correlate the symptoms of Dushivisha with the chronic occupational poisoning and agricultural field exposure to weed killers, which may be helpful to understand the concept of Dushivisha. It is very important for us to realize the health hazardous effects of cumulative poison and its proper time to time prevention as well as its proper treatment. Keywords Dushivisha, Occupational Poisoning, Agricultural Poisons Greentree Group Received 01/03/17 Accepted 29/03/17 Published 10/05/17 ________________________________________________________________________________________________________ Salve et al. 2017 Greentree Group © IJAPC Int J Ayu Pharm Chem 2017 Vol. 6 Issue 3 www.ijapc.com 18 [e ISSN 2350-0204] Int J Ayu Pharm Chem INTRODUCTION duration also leads to ill health effect. In The term Dushi Visha is a combination of present era we can correlate these two health two different types of words, Dushi and hazards to concept of Dushivisha. Visha. Dushi means denatured, attenuated, Chronic illness is more alarming than acute latent and vitiated. Visha means poison1. illness. In acute infections, there are marked Attenuated and denatured poisons function symptoms, so as it is easy to diagnosis and as latent toxin in the body. In Ayurveda, treat. Whereas in chronic illness, the while describing Visha, visha classified in symptoms are vague and difficult to various catagories such as Sthavar-jangham, diagnose. In Industrial chronic poisoning the Gara-Dushi Acharya symptoms are not well marked and can be describe dushivisha as a slow poison which misdiagnosed with other systemic illness. accumulates in our body, due to its low And it can be health hazardous due to wrong potency it does not produce acute ill effect diagnosis. So it is very important to learn but produces chronic illness due to long about chronic cumulative poisoning and its term While ill effect. This chronic poisoning is can be simplifying this concept of DushiVisha in co related with concept of dushi visha. In present era, we can compare the same effect Ayurveda, detoxification therapy is well of occupational chronic exposure to human explained for the treatment of Dushivisha. beings with poisons such as lead, arsenic, To prove utility of detoxification process, it mercury, copper etc. Workers in such very important to co relate the lakshana of industries, comes direct contact with poisons dushi visha with cumulative poisoning. In and that to for decades of duration which this review article an attempt has been made ultimately leads to chronic accumulation of first to understand concept of Dushivisha, its the poison in their body and that lead to signs, symptoms and line of treatment of chronic illness. Farmers working on field Dushivisha also has similar kind of chronic exposure to occupational hazards as well as poisoning of poisons such as OCP, OPP, paraquat, various agricultural products. Visha, exposure to etc. the All poison. with special reference to chlorophenoxy acetate, chlorates which are used as weed killer to prevent infection to the crops. This kind of exposure for longer ________________________________________________________________________________________________________ Salve et al. 2017 Greentree Group © IJAPC Int J Ayu Pharm Chem 2017 Vol. 6 Issue 3 www.ijapc.com 19 [e ISSN 2350-0204] Int J Ayu Pharm Chem AIM not get eliminated from body, but due to The conceptual study of DushiVisha in digestion or due to antidotes presence their present era w.s.r. to occupational hazards potency get decreased by the effect of and agricultural poisons. Aatap(sunlight) OBJECTIVES factors) this cumulative poison stays in 1) body. This low potency poison is known as To collect and analyze the literature Vayu (air) (external review of Dushi Visha. Dushivish2. 2) According to Astang Samgrah Samhita, To collect and analyze occupational hazards. 3) poisonous substances which are very old, To collect and analyze the contaminated with other anti poisonous agricultural poison and its effect on body drugs, partially destroyed by forest fire, 4) breeze, sunlight, not endowed fully with all Visha To compare the symptoms of Dushi with occupational hazards and qualities of poison by nature itself- all these agricultural poisons. derive the name dushivisha. Because of its Methodology alpa veerya (low potency), it does not To fulfill the aims and objectives of the produce acute symptoms (though present study this work has been carried out in the inside the body). It gets Avarana (covering) following phase wise manner. with kapha and remains in the body for 1) Conceptual study many years. Due to Avarana of Kapha and 2) Comparative study alpa Veerya, this Dushivisha stays in body 3) Discussion in Avyakta Avastha (invisible state) for 4) Conclusion and summary longer time3. Concept of DushiVishaInAyurveda- Lakshana of Dushivisha- According to Aacharya Sushruta, a poison which is vitiated by area, time, food and Nidra (sleep), Jrumbha, Gurutva, Harsha, Divaswapa (afternoon sleep) and which sandhi vishleshana, Angamarda (bodyache) vitiate the Deha Dhatus are called as these are the Purvaroopas of Dushivisha [2]. Dushivisha poisons) A part of Sthavar (plant Jangham (animal poison) or Purvaroopa of Dushivisha- which can be correlated with anxiety, drowsiness, body ache, weakness, joints KrutrimVish (artificial poison) which does ________________________________________________________________________________________________________ Salve et al. 2017 Greentree Group © IJAPC Int J Ayu Pharm Chem 2017 Vol. 6 Issue 3 www.ijapc.com 20 [e ISSN 2350-0204] Int J Ayu Pharm Chem weakness etc. premonitory symptoms of Hastapaadshotha Oedema on extremities dushivisha4. Dakodara Ascites Chhardi Emesis Vishamjvara Fever Unmada Insanity principally vitiate Rakta (blood) which lead Anaha Distention to Kitibh Koth Utpatti (skin disorder) in Shukrakshaya Oligospermia body, like this DushiVisha vitiate one by one SwaraVikruti Change in voice Roopa of Dushivisha- According to Aacharya charaka, Dushivisha Dosha and ultimately lead to Pran-nasha Table 3 According to Dhatu that contaminated by (death)5. Table 1 Dushivisha Lakshana varies8] According to Lakshana(signs) of Dushivisha Aachrya Sushruta 6 Rasa Dhatu Aruchi, Ajirna Atisaar Diarrhoea RaktaDhatu Kushtha, Visarpa (Herpes) TvakaVaivarnya Depigmentation of skin MansDhatu Mansarbud (Tumour) MukhaDaurgadhya Foul smell from mouth Med Dhatu Med Granthi (Lipoma) Virasta Nausea AsthiDhatu AsthiDantadiVikara(Osteological Trushna Thirst Murchha Syncope Vaman Vomiting SwarVaikrutya Hoarseness of voice Dushyodar Ascitis changes) MajjaDhatu TamoDarshana (Blurred vision, black outs) ShukraDhatu Klaibya (Infertility) Occupational hazardsOther Lakshana includes Lead industry-9 If Dushivisha is in Amashaya (stomach) it Lead is a typical cumulative poison. It is will lead to have Kapha-VaataVikara, if it is heavy steel gray metal. Metallic lead and all in Pakvashaya (colon), it will lead to its VataPittaVikara7. Industries such as Sindur making, batteries, Table 2 Other Lakshana paints, hair dyes, electric cable insulations, salts are poisonous.Occupational Annamada Nausea ceramics may lead tochronic exposure. The Avipaka, Arochaka Anorexia lead poisoning symptoms are Facial pallor- Mandala skin blisters Moha, Dhatukshaya Weakness Kotha Leprosy earliest sign, Anaemiapunctate basophilia (RaktaDhatuDushti), Burtonian line- on gums (MukhaDaurgandhya),Colic and ________________________________________________________________________________________________________ Salve et al. 2017 Greentree Group © IJAPC Int J Ayu Pharm Chem 2017 Vol. 6 Issue 3 www.ijapc.com 21 [e ISSN 2350-0204] Int J Ayu Pharm Chem constipation (Aanaha, palsy and (Unmada),Sterility Ammenorhoea Anorexia Dushyodar),Lead of (Klaibya, (Aruchi, Hepatic- Hepatomegaly, jaundice, cirrhosis encephalopathy of the liver both Hematologic- bone marrow suppression, sexes, Shukrakshay), Ajirna),Vertigo, anemia, leukemia Mercury Industry – drowsiness (Murchha). All these symptoms If mercury is inhaled or swallowed as vapor, of lead poisoning are similar to Lakshanas or if applied to the skin or mucus membrane of Dushivisha. in Arsenic Industry- absorbed.Industries such as glass blowing Arsenic is not absorbed from alimentary mirror canal, when volatilised by heat, arsenic exposure to elemental mercury yields classic unites with oxygen, and forms poisonous symptoms like- vapours of arsenic trioxide10. It is used Gingivitisandsalivation- blue line of gums industrially as an alloying agent, as well as Tremors- hatters shakesand in the processing of glass, pigments, textiles, Neuropsychiatricchanges paper, Mercurilentis - is peculiar eye change due to metal adhesives, wood finely divided state manufacturing it is firms.Chronic preservatives11. It may be due to accidental exposure tovapor of mercury ingestion of repeated small doses by those Acrodynia– anorexia, insomnia, sweating, who working in with the metal12. skin rash, photophobia. Symptoms commonly observed due to All above are occupational hazards effect of chronic exposure of Arsenic like- industrial poisoning13. CNS-polyneuritis, encephalopathy Agricultural poisons Skin- rain drop type of pigmentation on More than thousand chemicals are currently flexures, temples, eyelids used as insecticides and pesticides14. Nails-Aldrich-Mees lines Organic phosphorouscompounds- Eyes- watering of eyes, photophobia Organo phosphorous compounds used as GIT- nausea, vomiting, abdominal cramps, insecticides, pesticides on large scale in diarrhoea, salivation agriculture industry.Commonly used are, CVS and Kidneys - chronic nephritis, bugsoline(malathion), tick (diazion). They cardiac failure are absorbed by inhalation through the skin, ________________________________________________________________________________________________________ Salve et al. 2017 Greentree Group © IJAPC Int J Ayu Pharm Chem 2017 Vol. 6 Issue 3 www.ijapc.com 22 [e ISSN 2350-0204] Int J Ayu Pharm Chem mucous membrane and GI tract. When Chronic exposure may lead to following sprayed in air, absorption in the plants symptoms are Convulsion,Rhinorrhoea, sore occurs through leaves and stems15. throat, wheezing, and with skin contact- Chronic poisoning usually occurs as blisters, dermatitis, parasthesia. occupational hazards in agriculturists. DISCUSSION – The main features are - Toxicity is nothing but a substance that can Muscle cramps, Weakness,Gait disorder, harm or alter well being of an individual. parasthesia, Drowsiness, confusion, anxiety, Chronic toxicity refers to ability of a toxic Peripheral neuropathy, flaccid paralysis, toes substance to cause harmful effects over an drop extended period usually upon continuous Organo chloride compound poisoning- exposure. Organo chloride compound used as weed occupational or agricultural poisons, enter killers, herbicides in farms by farmers.e.g., the body in the form of air, water, soil, DDT, gamma hexachlorobenzenes( lindane), vapour. And usually it does not get endosulphan, endrin completely eliminated from the body. This organochlorines are absorbed through skin, repeated accumulation of ingredients lead to orally and via inhalation.These agents are cumulative highly lipid soluble16. AacharyaCharaka, Chronic exposure may lead to following AachryaVaghbhata symptoms are vomiting, nausea, salivation, Dushivisha is of any type Sthavar (plant diarrhea, Hoarseness poisons) of voice, mental Chronic exposure toxicity. Jangham In of this Ayurveda, AachryaSushruta, and are (animal opined poison) that or confusion, Loss of weight, weakness, ataxia, KrutrimVish (artificial poison) which does tremors, Oligospermia, Increased tendency not get eliminated from body, but due to for leukemia, anemia. digestion or due to antidotes presence their Pyrethrins and Pyrithroids- potency get decreased. Bythe effect of Pyrethrins and pyrithroids used as insect Aatap(sunlight), Vayu (air) Jala like external repellents, factors insecticides, pesticides. And this cumulative poison stays in Available as sprays, dusts, powders, mats, body. This low potency poison are known as coils. Most common used are pyrethrum, Dushivisha. permethrin, allethrin. ________________________________________________________________________________________________________ Salve et al. 2017 Greentree Group © IJAPC Int J Ayu Pharm Chem 2017 Vol. 6 Issue 3 www.ijapc.com 23 [e ISSN 2350-0204] Int J Ayu Pharm Chem CONCLUSION From above study, DushiVisha the Lakshana described of in BruhatrayiSamhita,are near about similar to that of cumulative poisons find in today’s occupational and agricultural industry. The concept of DushiVisha which described in ancient time that totally resemble in today’s lifestyle also, and this shows how deeply our Aacharyas studied about poisons and their property, so as in today’s era also we can co relate DushiVisha with our occupational hazards. It is alarming for us, to have sound knowledge of such silent poisoning, which is hazardous to our health. It is important to eliminate such DushiVisha exposure from our lifestyle so that we can live a healthy and poison free life. ________________________________________________________________________________________________________ Salve et al. 2017 Greentree Group © IJAPC Int J Ayu Pharm Chem 2017 Vol. 6 Issue 3 www.ijapc.com 24 [e ISSN 2350-0204] Int J Ayu Pharm Chem REFERENCES 8. 1. Defination of dushivisha available from: Sushrutasamhita [Hindi translation] volume http://www.researchgate.net/publication/281 1 378084_concept_of_cumulative_toxicity_D Sanskrit Sansthan, 2005, p-26 ushi_Visha_in_Ayurveda 9. 2. Dr. Anantram Sharma. Sushrutasamhita Of Forensic Medicine And Toxicology, K. [Hindi translation] volume 2, Varanasi: Suguna Devi, Hyderabad, 2011 p-497 chaukhambhasurbharatiPrakashan, 2012 p- 10. 523, 524 AmritPatnaik, 3. 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Parikh, Parikh’s Text Book of Medical Jurisprudence and Toxicology, New Delhi : CBS Publishers 2005 p-10.45 ________________________________________________________________________________________________________ Salve et al. 2017 Greentree Group © IJAPC Int J Ayu Pharm Chem 2017 Vol. 6 Issue 3 www.ijapc.com 26 [e ISSN 2350-0204]
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