Developing pH nano sensor with built-in self-calibrating
capabilities.
Health Work Program: PHC 11–2015:
Proposed Project Description:
The pH of blood is regarded as an important indicator of human
health. The acidity balance in extracellular fluids is tightly regulated
by physiological buffering systems and body organs, so that the
pH level of arterial blood is tightly kept within a very narrow range.
Our proposal is developing new, rapid, miniature, biocompatible
and highly sensitive pH sensors with built-in self-calibrating
capabilities. The self-calibrating nanosensors capable of
ratiometerically measuring absolute pH values in real-time at
physiological conditions, without the requirement of insufficient
precalibration and not susceptible to detrimental measurement
artifacts.
Partners search: BioNano Electronics, Biochip
UK-IL
Brokerage Event
June 2014
Cancer metabolism
Metabolites
Oxidase enzyme
pH change
H2O2
ROS & H2O2
15
Vapor-liquid-solid (VLS) growth mechanism for Silicon nanowire synthesis
Si NW Thickness: ~30 nm
Si NW Length: ~15 µm
7
Defining the Metal Contacts of the Device
D
S
D
G
8
SiNW p-type Felid effect transistor (FET)
Vg:–5, –4, –3, –2, –1, 0, 1, 2, 3 Volt
Vsd=1 volt
No current
9
Nano-wire nanosensor for pH
detection
Chip design and fabrication
Built-in self-calibrating
Si/SiO2
NW1
NW2
Si/Al2O3
3
Si/ZnO
NW3
Thank you
Amos Bardea; [email protected]
Holon Institute of Technology-HIT:
Fernando Patolsky; [email protected]
Tel Aviv University
Partners search: BioNano Electronics,
Biochip