The Professor’s New Find: Hesperidin
The relentless researcher rides into the past ...
By Dr. Joyce Block
See this month’s article on page 4
Across
1. Researchers found that pretreatment
with 50 μM hesperidin significantly
attenuated the release of cytochrome c
into the cytosol, demonstrating hesperidin
mitochondrial _____. Clue: defense
2. Additional data on hesperidin as an antidepressant concluded that “[h]esperidin
seems to be a viable candidate for the
treatment of major depression.” True or
false?
5. Ischemia-reperfusion (I/R) describes a
mechanism of injury occurring when
_____ flow to a tissue is temporarily
blocked or reduced and then flow is
restored. Clue: red flowing liquid
6. The phrase “happy juice” refers to the
fact that hesperidin also has
antidepressant-like effects in animals. Clue:
how learning about the power of
nutritional science makes me feel
7. Based on newer discoveries about
hesperidin, it may help reduce the risk of
Alzheimer’s _____ Clue: illness
10. Hesperidin pre-treatment was protective against I/R Injury in
rats attenuating mitochondrial dysfunction and memory
_____. Clue: the state of harm
11. Quantitative analysis, as shown in two recent papers,
demonstred that the cells treated with hesperidin had a 50%
decrease in _____ death. Clue: nerve cell (adj.)
13. Hesperidin protects against amyloid beta-induced _____
damage. Clue: a poison that acts on the nervous system
14. The release of endogenous opioids by exercise is thought to
be one reason for the antidepressant effect of _____. Clue: a
free anti-aging activity
15. _____ is an “oldie but goodie” research subject that remains
of interest because scientists keep finding new aspects of its
functionality. Clue: a flavonoid found in citrus fruits
16. Rat studies of continous or interval swimming combined with
hesperidin intake lowered _____ cholesterol (–16%), LDL
cholesterol (–50%) and triglycerides (–19%), and increased
HDL cholesterol (+48%). Clue: complete
Down
1. Among other benefit reports mentioned in the article and
associated with hesperidin are: mild sedation, antihypertensive,
psychostimulant, anticarcinogenic. Clue: which benefit does
not belong?
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L IFE enhancement
APRIL 2014
3. Researchers note that previous studies report that hesperidin
inhibited the _____ HMG CoA-reductase that synthesizes
cholesterol which is the same _____ that is inhibited by statin
drugs to reduce LDL cholesterol. Clue: biological molecule
4. Because Durk & Sandy want to continuously improve their
products, hesperidin has been added to their _____
formulation. Note on motivation: We take these products
ourselves.
8. When severe enough, I/R can result in heart attack or _____.
Clue: when brain cells die because of lack of oxygen
9. New findings on old _____ keep on piling up and can come
as a real surprise. Clue: to search again
12. Clinical findings indicate that depressed patients displayed a
deficiency of endogenous opioid activity, while manic patients
display _____ opioid activity. Clue: surplus
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