12-03-14 Program 1947 • Training Exercise physiology and training in children and adolescents with cerebral palsy – Training principles – Training in children • Training children with CP – Practical considerations Training in children Muscle Strength Aerobic capacity Training • Physical training: The process whereby repeated “systematic” exercise leads to functional and morphological adaptations in the body. FITNESS Anaerobic capacity “Training principles” • The PRINCIPLES of TRAINING are the rules to follow when using physical activity programs: • Specificity • Reversibility • Adaptation/Supercompensation Olaf Verschuren AusACPDM Specificity • In order for a training program to be beneficial, it must improve the specific physiological capabilities required to perform a given sport or activity. Specificity • Example, a goalkeeper needs to focus on reaction work in their training, in comparison to a midfielder who should focus on agility, stamina, speed etc. • A runner who wants to improve his leg strength, should train differently to a cyclist. Both would need muscular endurance but the training method should be different !! 1 12-03-14 Reversibility Adaptation/Supercompensation • “Use it or lose it.” • When you stop training, the training effects can be reversed – so don’t quit! • The training history will be an important factor. The longer you have trained the longer the effects will be present. • In order to improve through training we need to apply greater demands on our body. This is the principle of OVERLOAD. Is it possible to train children? Training in typically developing children Typically developing children % improvement after training 16 14 12 10 8 6 4 2 0 children adults • The body will adapt to the new norm. The three most important aspects of training • Little progression after training compared to adults (5-8% vs. 10-15%) 1. FUN • Program: “carefully adapted to each individual’s potential” 2. FUN 3. FUN Payne VG, Morrow JRJ (1993) Exercise and VO2max in children: a metaanalysis. Res Q Exerc Sport 64:305-13. Baquet G, van Praagh E, Berthoin S. Endurance training and aerobic fitness in young people. Sports Med. 2003;33(15):1127-43. Fitnesslevels in CP Low fitness How to develop a fitness training? Olaf Verschuren AusACPDM lopers High fitness rolstoelrijders 2 12-03-14 Fitnesslevels in children with CP Fitnesslevels in children with CP Muscle strength (HHD) • Muscle strength (HHD) • Aerobic capacity – Lundberg A 1984 • Low compared to typically developing peers control hemiplegic diplegie 8 7 6 5 4 3 2 1 0 dominant side PF (F) DF (F) PF (E) muscle groups DF (E) QU 30 QU 90 ABD ADD HAMS GLUT ILOP Testuitslagen RECT PF (F) muscle groups DF (F) PF (E) DF (E) QU 30 QU 90 ABD ADD HAMS RECT Strength non dominant side GLUT ILOP Strength control hemiplegic diplegic 8 7 6 5 4 3 2 1 0 Percentage of predicted values – Damiano et al, 1998 Muscle strength right side (n=47) Fitnesslevels in children with CP • Aerobic capacity Fitnesslevels in children with CP Fitnesslevels in children with CP • Anaerobic capacity • Anaerobic capacity – Verschuren et al. 2008 (submitted) – Verschuren et al. 2013 – Bar-Or et al 1996; Parker et al 1992 Female 600 600 Male 550 450 450 II) 400 350 300 Mean Power 250 350 200 S I or 300 y (G MFC Mean Power pals 0 0 50 50 100 100 150 150 bral 400 Typically develo ping Cere 250 I or II) 200 Cerebral palsy (GMFCS no CP level I level II 500 550 no CP level I level II 500 ing Typically develop 110 120 130 140 150 160 170 180 110 120 130 Height Low fitness High fitness % of the observation Fitnesslevels in CP M St us re cle ng th children's play 60 55 50 45 40 35 30 25 20 15 10 5 0 , irs sta ing g k, alk yin ee W pla nd s a . e etc hid anaëroob 0 3 6 9 12 15 lopers Aerobic capacity us em en Cy Sport t Pa clin s, rk, g, etc . 21 24 27 30 33 36 160 170 180 Muscle Strength FITNESS aëroob 18 150 Height Fitnesstraining Am duration of the activities (in sec.) 140 267 Anaerobic capacity rolstoelrijders Olaf Verschuren AusACPDM 3 12-03-14 Effect of aerobic training Muscle Strength Training is ?? Training is ?? 3 RCTs: van den Berg-Emons et al. 1995, Unnithan et al. 2007, Verschuren et al. 2007 Trainingsprogram 2-4 months à ↑ aerobic fitness of 18–22% Trainingsprogram 8-9 months à ↑ aerobic fitness of 26-41% Content aerobic training Cerebral Palsy Aerobic capacity Cerebral Palsy Fitnesstraining Duration of the training: 18-45 minutes 2 to 4 times a week 3-9 months Trainingsintensity between 60-80 % of HRmax. FITNESS Anaerobic capacity Training is ?? Typically developing Trainingsprogram of 5 months à ↑ anaerobic fitness of approx. 25% No clear evidence in current literature. Training seems beneficial Different training modalities - Progressive Resistance Exercise Cerebral Palsy 1 RCT: Verschuren et al. 2007 Trainingsintensity between 55-‐89% of HRmax. Content anaerobic training Typically developing Cerebral Palsy Effect of anaerobic training Trainingsprogram 4 weeks tot 18 months à ↑ aerobic fitness of 5-10% Typically developing Typically developing ACSM guidelines: Duration of the training: 20-60 minutes 3 times a week 4-12 months Strength training in children with Cerebral Palsy Trainingsintensity maximal during exercises of 20-30 seconds Guideline short-term and intermediate term anaerobic capacity Trainingsintensity maximal during exercises of 10-30 seconds Effect of resistance training on MUSCLE STRENGTH Effect of resistance training on GMFM Lower extremity Lower extremity Upper extremity Electro stimulation Electro stimulation - Electro stimulation What works? N= 119 Olaf Verschuren AusACPDM Muscle strengthening is not effective in children and adolescents with cerebral palsy: A systematic review. Scianni A, Butler JM et al. Aust J Physiother 2009; p81-87 N= 99 Muscle strengthening is not effective in children and adolescents with cerebral palsy: A systematic review. Scianni A, Butler JM et al. Aust J Physiother 2009; p81-87 4 12-03-14 Effect training on WALKING SPEED Lower extremity Discussion • Different methods in 1 review / metaanalysis Electro stimulation • If there is no effect on muscle strength or activity level à is training still worthwhile? N= 63 Progressive resistance exercise is most o0en used. Is this method effec7ve? Muscle strengthening is not effective in children and adolescents with cerebral palsy: A systematic review. Scianni A, Butler JM et al. Aust J Physiother 2009; p81-87 Effect of resistance training for the lower extremity in children and adolscents CP NSCA guidelines Important ingredients according to the NSCA guidelines • Warming-‐up (5-‐10 minutes) • Type of exercise • Intensity • Frequency (2-‐3 7mes a week) • DuraPon of the programme • Progression during the programme • Age of children Dodd et al. 2003 Liao et al. 2007 Lee et al. 2008 Scholtes et al. 2010 Total N= 105 Verschuren et al. PT journal 2011 RCTs in children with CP Type Result on muscle group level. Type of exercises: mostly functional based Type of exercises NSCA guidelines Dodd: multi-joint exercises” (heel raises, half squats and stepSingle-joint and ups) multi-joint exercises Liao: multi-joint exercises” (sit-to-stand) loaded (using weight vest) Lee: multi-joint exercises (squat to stand, lateral step up, stair up and down) loaded (using weight cuffs), Scholtes: multi-joint exercises (leg press) and loaded (using a weight vest) Study What is the trainingseffect on the muscle groups that were targeted? Dodd et al. Muscle groups targeted in 4 RCT’s: • Knee-extensors • Hip-extensors • Plantar flexors Ankle plantar flexors - Lee et al. Liao et al. Scholtes et al. - Knee extensors + Knee flexors - Hip extensors + - Hip flexors Hip abductors - - - - Hip adductors - Be aware of compensaPon during exercises! Olaf Verschuren AusACPDM 5 12-03-14 Duration of the programme Intensity of the programme RCTs in children with CP Intensity Dodd: Liao: 3 sets of 8-12 repetitions to fatigue 1 set of 10 repetitions at 20% 1RM 1 set of repetitions until fatigue at 50% 1RM 1 set of 10 repetitions at 20% 1RM Lee: 2 sets of 10 repetitions (low load and no progression) Scholtes: 3 sets of 8 RM RCTs in children with CP NSCA guidelines 1-3 sets of 6-15 repetitions of 50-85% RM Duration Dodd: Liao: Lee: Scholtes: NSCA guidelines 6 weeks 6 weeks 5 weeks 6 weeks (12 week program) Effect of resistance training of the lower extremity in typically developing children 8-20 weeks No study is in line with the NSCA guidelines Only 2 of the 4 studies are in line with the NSCA guidelines Significant relaPon between duraPon and trainingseffect: Behringer et al. Pediatrics Oct 25, 2010 Content of resistance training Age of training RCTs in children with CP Age Dodd: mean 13.1, SD 3.1, range 8-18 years of age Liao: mean 7.4, SD 1.6, range 5-12 years of age Lee: mean 6.3, SD 2.5, range 4-12 years of age Scholtes: mean 10.5, SD 1.1, range 6-13 years of age NSCA guidelines Age 7 and onwards In 3 out of the 4 studies included children younger than the recommended 7 years of age. Variabels RCTs in children with CP NSCA guidelines Type Dodd: Liao: Lee: multi-joint exercises” (heel raises, half squats and step-ups) multi-joint exercises” (sit-to-stand) loaded (using weight vest) multi-joint exercises (squat to stand, lateral step up, stair up and down) loaded (using weight cuffs), single joint exercises Scholtes: multi-joint exercises (leg press) and loaded (using a weight vest) Single-joint and multi-joint exercises utilizing concentric and eccentric contractions Intensity/ volume Dodd: Liao: 3 sets of 8-12 repetitions to fatigue 1 set of 10 repetitions at 20% 1RM 1 set of repetitions until fatigue at 50% 1RM 1 set of 10 repetitions at 20% 1RM Lee: 2 sets of 10 repetitions Scholtes: 3 sets of 8 RM 1-3 sets of 6-15 repetitions of 50-85% RM Duration Dodd: 6 weeks Liao: 6 weeks Lee: 5 weeks Scholtes: 6 weeks (12 week program) 8-20 weeks Age Dodd: mean 13.1, SD 3.1, range 8-18 years of age Liao: mean 7.4, SD 1.6, range 5-12 years of age Lee: mean 6.3, SD 2.5, range 4-12 years of age Scholtes: mean 10.5, SD 1.1, range 6-13 years of age Age 7 and onwards N= 1728 Recommendations • Longer interventions with sufficient intensity, for example, 12 weeks, may be needed to see significant or meaningful improvements in strength. Verschuren et al. PTjournal 2011 Recommendations Single-joint resistance training may be more effective for very weak muscles or for children or adolescents who tend to compensate when performing multi-joint exercises, or at the beginning of the training. Olaf Verschuren AusACPDM Recommendations Depending on the complexity of the exercise and the level of motor impairment, children and adolescents with CP may need more than 1 minute of rest between bouts (perhaps up to 3 minutes). Recommendations Since strength training, as it is traditionally done, requires maximal effort and can include somewhat complicated activities, older children and adolescents, over 7 years old, are perhaps better suited to this intervention that younger children. 6 12-03-14 Recommendations Training is effective Fitnesstraining CP Aerobic capacity Children or adolescents with more impairment might also benefit from strength training, but if it is difficult for them to contract voluntarily, methods such as electrical stimulation, mental imagery and biofeedback could be helpful. Training can be more effective EXAMPLE STUDY Muscle strength FITNESS Anaerobic capacity Training is effective Randomized Clinical Trial Aerobic capacity Muscle strength Goes Zwolle FUNCTIONAL Breda N=86 Utrecht N=65 FITNESS Trainingsscheme • • • • 8 months 2 times a week for 45 minutes 2 physical therapists 2 groups 1. 7 - 12 year 2. 13 - 20 year Randomized GMFCS level (I or II) Anaerobic capacity Fitnessprogram Experimental group Control group N = 32 N = 33 HRmax in children with CP Ingredients for training • In the training we used 8 standardized TASKSPECIFIC aerobic and anaerobic exercises, which were based on walking activities, such as – Running / Walking fast – Step up and down – Stepping over – Bending – Turning – Getting up from the floor Olaf Verschuren AusACPDM 7 12-03-14 Fitnesstraining guidelines The exercises Aerobic exercises Frequency: 2 days per week 8 standardized exercises Intensity: 60 - 80% max. HR Aerobic capacity Duration: Anaerobic exercises 45 minutes Activity:Rest: 8 standardized exercises Fitnesstraining guidelines Frequency: Training 1. Anaerobic capacity 2. 3. maximal Duration: Warming-up Training focus – In circuit format (with 2 children in each group) for aerobic part (month 1-3) – In group format for anaerobic part (month 4-8) 30 - 45 minutes Activity:Rest: 4. 1:3 1:5 Introduction – Explain purpose of training and give children heart rate monitor 2 days per week Intensity: 1:1 The effects of a functional fitness program in children and adolescents with Cerebral Palsy: a randomized trial Closure of the training Olaf Verschuren, Marjolijn Ketelaar, Jan Willem Gorter, Paul Helders, Tim Takken Randomization Aerobic capacity Muscle strength FUNCTIONAL FITNESS • Experimental group (n=32) • Control group (n=33) GMFCS I n=23 GMFCS II n=9 GMFCS I n=22 GMFCS II n=11 11.6 (2.5) years Boys/girls 18/14 12.7 (2.7) years Boys/girls 23/10 Objectives • Primary objective; Study the effects on: • aerobic capacity (10-m Shuttle Run Test) • anaerobic capacity (Muscle Power Sprint Test) • Secondary objective; Study the effects on: • Functional muscle strength • Agility • Participation • HRQoL Baseline Controlgroup: Anaerobic capacity Olaf Verschuren AusACPDM Traininggroup: 4 months 8 months Follow-up:12 months REGULAR PHYSIOTHERAPY TRAINING + REGULAR THERAPY REGULAR THERAPY 8 12-03-14 Results Aerobic and anaerobic capacity 8 months Control group 4 months 8 months 4 months % improvement P<0.001 baseline Experimental group 60 50 40 30 20 10 0 -10 -20 8 months 4 months 8 months baseline 4 months baseline % improvement Mean Muscle Power (MPST) Control group baseline 10-m Shuttle Run Test Experimental group 60 50 40 30 20 10 0 -10 -20 P=0.004 P-values: group(2) x time(3) interaction of repeated-measures analysis of variance Body Function and Structure Functional muscle strength 30-sec Repetition Maximum Experimental group P<0.001 Control group Olaf Verschuren et al. Ped Phys Ther 2007;19:108-115 • Children’s Assessment of Participation and Enjoyment (CAPE). Intensity 1,5 Significant (p<0.05) 1,4 Not significant 1,3 control group 1,2 8 months 4 months 8 months 1,1 baseline % improvement 8 months 4 months 8 months baseline -10 baseline 0 -5 4 months 5 4 months & improvement 15 10 16 14 12 10 8 6 4 2 0 Olaf Verschuren et al. Physical Therapy 2006;86(6): 1107-1117 For info MPST: Participation (intensity) 1,6 10x5 meter sprint test Control group 20 baseline Experimental group 25 Participation Children’s Assessment of Participation and Enjoyment (CAPE) Agility For info 10-m SRT: exp group 1 Recreational activities (+10%) Social activities (+0%) Self-improvement activities (+6%) Skill-based activities (+20%) Physical activities (+24%) 0,9 0,8 P<0.001 0,7 Overall activities (+27%) 0,6 P-values: group(2) x time(3) interaction of repeated-measures analysis of variance baseline + 4 months + 8 months For info 10x5 meter:Olaf Verschuren et al. Ped Phys Ther 2007;19:108-115 Health-related Quality of Life P-values: group(2) x time(3) interaction of repeated-measures analysis of variance Conclusion Follow-up Aerobic and anaerobic capacity • TACQOL-PF 10 meter shuttle run test Experimental group Control group 10 Olaf Verschuren AusACPDM 12 months 8 months baseline 15 10 5 12 months baseline 12 months 8 months 0 -5 P-values: group(2) x time(3) interaction of repeated-measures analysis of variance Control group 20 4 months Effective and Fun % improvement Global negative emotions (+2%) 4 months 12 months 8 months Mean Power (Watts) MPST Experimental group 25 8 months Easy to implement Cognitive functioning (+4%) 4 months Functionally based Global positive emotions (+2%) 4 months 0 -10 Social functioning (+2%) Autonomy (+4%) 20 baseline Not significant Pain and symptoms (+1%) Basic motor functioning (+10%) 30 baseline Significant (p<0.05) % improvement 40 9 12-03-14 Follow-up Participation Follow-up Muscle strength and agility Results of more studies Functionele spierkracht (30-sec HM) 25 Experimental group Control group 1,6 % improvement 20 15 Intensity 1,3 0 -5 1 0,7 0,6 +4 months +8 months follow-up 12 months 8 months 4 months baseline 12 months 8 months 4 months baseline baseline % improvement 0,8 Control group End of training Muscle Strength Based on rationale for RCT’s in published papers. Dodd et al. Lee et al. Scholtes et al. N= 105 and/or PERFORMANCE related problems Verschuren et al. PTjournal 2011 Aerobic capacity HEALTH related problems Olaf Verschuren AusACPDM Anaerobic capacity Trainingsprogram 4 months à ↑ anaerobic fitness 10% Trainingsprogram 8 months à ↑ anaerobic fitness 25% Agility Walking Speed Trainingsprogram 2-‐4 months à ↑ aerobic fitness 18–22% Trainingsprogram 8-‐9 months à ↑ aerobic fitness 26-‐41% PERFORMANCE related factors PERFORMANCE related factors GMFM CEREBRAL PALSY Berg-Emons et al. 1998: after 3 months ↓ 17% Verschuren et al. 2007: after 4 months ↓ 9 % Liao et al. GOAL Aerobic capacity Muscle strength Body Mass Index FOLLOW-UP HEALTH related factors Exercise programs: What’s the GOAL? Anaerobic capacity Motor skill Agility / Speed exp group 0,9 10x5 meter sprint test Experimental group 16 14 12 10 8 6 4 2 0 control group 1,1 12 months 8 months 4 months 12 months baseline 8 months 4 months 1,2 baseline -10 1,5 1,4 10 5 Trainingsprogram 4 months à ↑ agility 8% Trainingsprogram 8 months à ↑ agility 14% End of training FOLLOW-UP Verschuren et al. 2007: a0er 4 months Anaerobic capacity ↓ 9 % Agility ↓5% 10 12-03-14 Exercise programs: What’s the effect? Only during the intervenPon What have we done? ? follow-‐up too short HEALTH related problems and/or PERFORMANCE related problems No effect (at follow-‐up) Difficult to be acPve in daily life. LEARN 2 MOVE 7-12 Group fitness training Recent study LEARN 2 MOVE 7-12 Lifestyle intervention LEARN 2 MOVE 7-12 Program designed to improve physical activity Motivational Interviewing “A directive, client-centered counseling style to elicit behavior change by helping clients explore and resolve ambivalence.” (Rollnick & Miller 1995) + 3 x 12 hh Training • 16 weeks 1-2 times a week for an hour 15-20 seconds maximal! Motivational interviewing • 2-5 children per group Olaf Verschuren AusACPDM 11 12-03-14 Are we satisfied when we become succesful in increasing PHYSICAL ACTIVITY ? Results Learn to Move • The combination of counselling, homebased physiotherapy and fitness training was not effective in improving fitness, social participation in recreation and leisure, self-perception or quality of life. 30-60 min What have we done? Part 2. PHYSICAL ACTIVITY exercise continuum Sitting and mortality Sedentary physiology in children with CP Uptime (Pirpiris and Graham 2004) Sedentary pursuits Fitness level and mortality Definitions of Sedentary Behavior Evolution of definitions of sedentary behavior: • 2010. Sedentary behavior should be defined as the muscular activity rather than the absence of exercise. CP Cerebral palsy Mean hours per week diplegia hemiplegia Typically developing (Maher et al. 2007) CP = Coach Potato Low sedentary • 2011. The origins of the word ‘‘sedentary’’ hint at a simpler, more workable definition. The word sedentary derives from the Latin verb sedere—to sit. When sitting or lying, the majority of the body’s largest muscle groups are under relaxation; in contrast, when standing, even if still, a large proportion of the body’s musculature are under tension. Therefore any non-exercise activity that involves sitting or lying can be considered sedentary. Regardless of Physical Activity Van der Ploeg H et al. Arch Intern Med 2012:172(6):494-500 Important factors of Sedentary Behaviour • Posture (sitting or reclining) • Energy expenditure (≤ 1.5 METs) • Muscular inactivity • 2012. Sedentary behaviour is any waking behaviour characterized by an energy expenditure ≤ 1·5 METs while in a sitting or reclining posture. High sedentary Olaf Verschuren AusACPDM 12 12-03-14 What do we know about sedentary behavior in children with CP? ? ? ? EMG acPvity Energy expenditure EMG acPvity Energy expenditure EMG acPvity Energy expenditure Sitting Lying and sitting ? ? ? Standing Energy expenditure (METS) GMFCS level 0 (n=4) Rest (lying) 1.0 Sit with support I (n=4) 1.0 II (n=3) 1.0 III (n=6) Standing Standing 1.14 ± .07 Sit without support 1.17 ± .10 1.10 ± .10 1.11 ± .17 1.53 ± .04 1.10 ± .09 1.18 ± .15 1.54 ± .19 1.0 1.21 ± .19 1.33 ± .25 1.60 ± .25 IV(n=2) 1.0 1.03 ± .13 not possible 1.70 ± .06 V (n=1) 1.0 1.42 not possible 1.88 1.58 ± .10 Stand up for your health and ask a question? Muscle activity Summary GMFCS level 0 (n=4) Rest (lying) 1.0 Sit with support Sit without support 1.33 ± .59 1.38 ± .24 Standing I (n=4) 1.0 1.17 ± .58 .91 ± .21 2.35 ±1.0 II (n=3) 1.0 1.10 ± .47 1.68 ± 1.0 5.64 ±1.6 III (n=6) 1.0 1.22 ± .70 1.69 ± .73 4.76 ± 3.0 IV(n=2) 1.0 1.58 ± .46 Not possible 8.80 ± 2.6 V (n=2) 1.0 .77 ± .57 Not possible 1.7 ± 1.4 • Children with CP have low fitness levels. • Children with CP are able to increase their fitness levels. • It is difficult to become and stay physically active. • Even if we (or they) succeed, we are not doing enough. • We need to get them less sedentary. 3.77 ± .67 Take home message! Sleep Sedentary behavior* Light physical activity cut down, replace by Wake up Moderate physical activity Intense activity HEALTH ENHANCING PHYSICAL ACTIVITIES x passive transportation* Trip to and - walk or bike to school -brisk walk or bike fast to school - break up sitting every hour -PA lesson with Heart Rate > 64% HRmax from school sitting/reclining* - active play (recess) School After school Bed time Olaf Verschuren AusACPDM - break up sitting every hour -moderate to vigorous activities screen time* - active play (out- or indoors) -play (competitive) sports x 8 hours 1 sitting/reclining* 15 hours 30-60 minutes 13 12-03-14 Kind met een hulpvraag* Onderzoek** (oa. CP onderzoek, GMFM, krachttesten, GMFCS) Beperkt uithoudingsvermogen GMFCS I + II GMFCS III Beperkte kracht/ verwacht krachtsverlies*** GMFCS I + II GMFCS III Beperkt krachtuithoudingsvermogen GMFCS I + II GMFCS III CP trainingsgroep POPEYE + Principes CP trainingsgroep individueel Voor en/of na interventie**** CP trainingsgroep Principes CP trainingsgroep individueel CP trainingsgroep POPEYE * Kinderen met CP met een hulpvraag die gericht is op kracht en/of uithoudingsvermogen ** Meetinstrumenten volgens POPEYE- protocol *** Treedt vaak op pre- of postoperatief, na inactieve periode of tijdens Botox **** met interventie wordt hier bedoeld: Botox, SDR, of multilevel chirurgie Olaf Verschuren AusACPDM 14
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