PRODUCT INFORMATION
Bongkrekic Acid (ammonium salt)
Item No. 19079
Formal Name:
(2E)​-20-​(carboxymethyl)​-​6R-​
methoxy-​2,​5,​17S-​trimethyl2,​4Z,​8Z,​10E,​14E,​18E,​20Z-​
docosaheptaenedioic acid,
triammonium salt
Synonym:
Bongkrek Acid
MF:C28H38O7 • 3NH3
FW:537.7
Purity:
≥98%
Stability:
≥2 years at -20°C
Supplied as:
A lyophilized solid
O
O
HO
O
OH
O
• 3NH3
OH
Laboratory Procedures
For long term storage, we suggest that bongkrekic acid (ammonium salt) be stored as supplied at -20°C. It
should be stable for at least two years.
Bongkrekic acid (ammonium salt) is supplied as a lyophilized solid. A stock solution may be made by
dissolving the bongkrekic acid (ammonium salt) in the solvent of choice. Bongkrekic acid (ammonium salt)
is soluble in the organic solvent DMSO, which should be purged with an inert gas, at a concentration of
approximately 100 mg/ml. It is also soluble in water at a concentration of 1 mg/ml. We do not recommend
storing the aqueous solution for more than one day.
Description
Bongkrekic acid is a natural toxin first isolated from coconut tempeh contaminated with bacteria. It is a
polyunsaturated long-chain fatty acid derivative that acts as a potent inhibitor of the mitochondrial adenine
nucleotide (ADP/ATP) translocase (Ki < 2 nM).1-3 Despite its high affinity, bongkrekic acid has a slow rate of
action in intact preparations, as it must permeate the inner mitochondrial membrane to bind the translocase.3
References
1. Henderson, P.J.F. and Lardy, H.A. Bongkrekic acid. An inhibitor of the adenine nucleotide translocase of
mitochondria. J. Biol. Chem. 245(6), 1319-1326 (1970).
2. Dahout-Gonzalez, C., Hury, H., Trézéguet, V., et al. Molecular, functional, and pathological aspects of the
mitochondrial ADP/ATP carrier. Physiology (Bethesda) 21, 242-249 (2006).
3. Klingenberg, M. The ADP and ATP transport in mitochondria and its carrier. Biochim. Biophys. Acta
1778(10), 1978-2021 (2008).
WARNING
THIS PRODUCT IS FOR RESEARCH ONLY - NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
SAFETY DATA
This material should be considered hazardous until further information becomes available. Do not ingest, inhale, get in eyes, on skin, or on clothing. Wash thoroughly after
handling. Before use, the user must review the complete Safety Data Sheet, which has been sent via email to your institution.
WARRANTY AND LIMITATION OF REMEDY
Buyer agrees to purchase the material subject to Cayman’s Terms and Conditions. Complete Terms and Conditions including Warranty and Limitation of Liability information
can be found on our website.
Copyright Cayman Chemical Company, 02/12/2016
CAYMAN CHEMICAL
1180 EAST ELLSWORTH RD
ANN ARBOR, MI 48108 · USA
PHONE: [800] 364-9897
[734] 971-3335
FAX: [734] 971-3640
[email protected]
WWW.CAYMANCHEM.COM