(a)
Melanoma
80
Percentage of all mutations
70
60
50
40
30
20
10
0
C to T
G to A
(b)
C to G
G to C
C to A
G to T
T to G
A to C
T to A
A to T
T to C
A to G
T to A
A to T
T to C
A to G
Small cell lung cancer
40
Percentage of all mutations
35
30
25
20
15
10
5
0
G to A
C to T
G to C
C to G
G to T
C to A
T to G
A to C