Appropriate Chemotherapy Dosing For Obese Adult
Patients With Cancer: ASCO Clinical Practice Guideline
Calculation Tools for Body Surface Area (BSA)
And Body Mass Index (BMI)
Carboplatin Calculation Resource
Formula Name
Formula
Total Dose (mg) = (target AUC) X (GFR + 25)
Calvert
BSA Calculation Resources
Formula Name
Formula
Chemotherapy is usually dosed by square meter of body surface area (BSA). BSA has been chosen rather than body weight as the basis for
calculation for two reasons. First, BSA has been demonstrated to provide a more accurate comparison of activity and toxicity for certain drugs.
Second, BSA can be more closely correlated with cardiac output, which determines the blood flow to the liver and kidneys, thus influencing drug
elimination.
Boyd
BSA (m2) = 0.0003207 x Ht(cm) 0.3 x weight(g)(0.7285 – ( 0.0188 x LOG10weight(g)))
DuBois and DuBois
Gehan and George
Haycock, et al.
Mosteller (Adults and Children)
Please note: Calculators using these formulas are available online
BSA(m2) = Wt(kg)0.425x Ht(cm)0.725 x 0.007184
BSA(m2) = Wt(kg)0.51456x Ht(cm)0.42246x 0.0235
BSA(m2) = Wt(kg)0.5378x Ht(cm)0.3964x 0.024265
BSA(m2) = SQR RT((Ht(cm) x Wt(kg))/3600)
or
2
BSA(m ) = SQR RT((Ht(in) x Wt(lb))/3131)
BMI Calculation Resources
Measurement in Units
Formula and Calculation
For adults 20 years old and older, BMI is interpreted using standard weight status categories that are the same for all ages and for both men and
women. Visit Adult BMI Calculator
For children and teens, on the other hand, the interpretation of BMI is both age- and sex-specific. For more information about interpretation for
children and teens, visit Child and Teen BMI Calculator.
BMI is calculated the same way for both adults and children. The calculation is based on the following formulas:
Formula: weight (kg) / [height (m)]2
Kilograms and meters (or centimeters)
With the metric system, the formula for BMI is weight in kilograms divided
by height in meters squared. Since height is commonly measured in
centimeters, divide height in centimeters by 100 to obtain height in
meters.
Example: Weight = 68 kg, Height = 165 cm (1.65 m)
Calculation: 68 ÷ (1.65)2 = 24.98
Formula: weight (lb) / [height (in)]2 x 703
Pounds and inches
2
Calculate BMI by dividing weight in pounds (lb) by height in inches (in)
squared and multiplying by a conversion factor of 703.
Example: Weight = 150 lb, Height = 5'5" (65")
Calculation: [150 ÷ (65)2] x 703 = 24.96
NOTE: For adults, a BMI of 25.0 to 29.9 is considered overweight and a BMI of 30.0 is considered obese.
This practice tool for physicians is a dosing table derived from an ASCO® practice guideline. The practice guideline and this table are not intended to substitute for the independent professional judgment of the treating
physician. Practice guidelines do not account for individual variation among patients and may not reflect the most recent evidence. This table does not recommend any particular product or course of medical treatment.
Use of the practice guideline and this table is voluntary. The full practice guideline and additional information are available at http://www.asco.org/guidelines/wbd.
The Expert Panel for this Guideline wishes to express its gratitude to Shauniece Morris for her assistance in the development of this tool.