Primary Type: Lesson Plan
Status: Published
This is a resource from CPALMS (www.cpalms.org) where all educators go for bright ideas!
Resource ID#: 27072
ATP Please!
This lesson aims to assist students in making the connection between cell respiration, mitochondria, and ATP. Using guided inquiry and independent
reading, students will be prepared to present a clinical case study on a mitochondrial myopathy to the class.
Subject(s): Science
Grade Level(s): 9, 10, 11, 12
Intended Audience: Educators
Suggested Technology: Computer for Presenter,
Computers for Students, Internet Connection, LCD
Projector, Overhead Projector
Instructional Time: 2 Hour(s)
Freely Available: Yes
Keywords: ATP, ATP synthase, energy, Mitochondria, glucose, energy transfer, cell respiration, electron transport
Resource Collection: FCR-STEMLearn Cell Biology
ATTACHMENTS
ATP_Quiz.docx
ATP_Quiz_KEY.docx
ATP_Synthesis_Worksheet.docx
ATP_Synthesis_Worksheet_Key.docx
Mito_Disease_Case_Study.docx
Mito_Disease_Case_Study_KEY.docx
LESSON CONTENT
Lesson Plan Template: Learning Cycle (5E Model)
Learning Objectives: What should students know and be able to do as a result of this lesson?
The student will:
Identify the three primary steps involved in producing ATP through aerobic cell respiration
Locate the sites within the cell where these respiration steps take place
Relate a mitochondrial disease with a physiological response
Prior Knowledge: What prior knowledge should students have for this lesson?
Prior Knowledge: Students should already know
The Laws of Thermodynamics
The energy molecule adenosine triphosphate (ATP) is the energy currency of a cell
Cells are able to break down organic fuel molecules to produce ATP
Energy is the capacity to cause change and can exist as kinetic, thermal, potential, or chemical energy
page 1 of 3 Guiding Questions: What are the guiding questions for this lesson?
Guiding Questions:
1. How is energy (ATP) produced and used in a cell?
2. What is the role of mitochondria in converting chemical energy from food to ATP, a usable form of cellular energy?
Teaching Phase: How will the teacher present the concept or skill to students?
This lesson focuses on the role of mitochondria in producing ATP for cellular function. Students will understand the primary processes of aerobic cell respiration and
the importance of where these events take place. To engage more deeply with the role of mitochondria in ATP production, students will use a Case Study approach to
connect mitochondrial mutations with muscle function.
DAY 1
The teacher will introduce this lesson on ATP by assigning the video Powering the Cell: Mitochondria (2:08) for the students to watch the night before.
The next class period, the teacher will facilitate a second viewing of the video where he/she will stop and point out certain structures or processes. This will provide
context for the lesson content.
0.15 - mitochondria moving through the cell attached to cytoskeletal elements
0.50 – ATP being used by proteins for cellular work
1.0 - surface of the lipid bilayer
1.1 - ATPase motor protein turning in the mitochondrial membrane to produce ATP
Teacher will pass out the Guided Inquiry ATP Synthesis Worksheet for students to complete using figures and other available text (textbooks or the Internet) at
the teacher’s discretion. After 10 minutes bring the students attention back to the class and using an overhead or computer, project the questions and figures. Go
over the material by soliciting responses from students; provide discussion so that the students understand the correct answer. (Key provided.)
After the students understand the role of mitochondria in synthesizing ATP, tell them that there are genetic disorders of the mitochondria that often result in poor
muscle function due to insufficient ATP. Explain to the students that they will play the role of a medical student participating in a Case Study method of
understanding the diseases associated with mitochondrial mutations. (Case Study is a mechanism medical students and practitioners often use to share information
about patients.)
Pass out the Mito Disease Case Study for students to see what their task will be. Have them read the document on their own and then divide up into groups of 34. Students will need to use the Internet to research diseases that results from lack of efficient ATP production. There are many tissues affected by mitochondrial
defects but the Case Study should focus on muscle weakness and/or the nervous system as the primary symptom. (Suggested sites:
http://www.mda.org/disease/mitochondrial-myopathies/overview and http://www.mitoresearch.org/mitodiseases.html)
DAY 2
Direct the students back to the Mito Disease Case Study Worksheet and have each group create a fictional patient profile that would fit the expectations of a
mitochondrial disease. They can continue to use their reference sources as they complete this task.
Groups will present their Mito Disease Case Study to the class to explain the factors that may be responsible for the patient’s lack of energy or muscle weakness.
This can be an oral or poster presentation depending on your class level.
After the presentations have been completed, discuss as a class the suggested errors in normal mitochondrial function that were presented by the groups (see
Mito Disease Case Study Key). Using a show of hands, ask for the scenario that best explained the cellular defect that results in poor ATP production.
If time allows, rewatch the video Powering the Cell: Mitochondria and make sure to point out the ATPase and the direction of the H+ that flow. (See Closure
below.)
Lastly, the students will complete the ATP Please! Quiz (see ATP Please! Quiz Key).
Guided Practice: What activities or exercises will the students complete with teacher guidance?
The teacher will lead the students through the video on the mitochondria and pose questions and help the students understand what they are viewing.
The ATP Synthesis Worksheet activity will be followed up with a class discussion to make sure the students understand the answers.
Independent Practice: What activities or exercises will students complete to reinforce the concepts and skills developed in the
lesson?
The students will use a guided inquiry process to understand events in cell respiration and complete a worksheet with relevant questions.
As described in the Teaching Plan, the students will develop a clinical case study of a fictional patient following independent and group research of mitochondrial
diseases. Student groups will create a specific scenario and explain the factors that may be responsible for a patient with mitochondrial myopathy producing
insufficient ATP.
One student per group will be chosen as the presenter and will explain their case scenario and conclusion to the classroom.
Closure: How will the teacher assist students in organizing the knowledge gained in the lesson?
The teacher and students will then rewatch the video "Powering the Cell: Mitochondria" and review/update comments about what is taking place in the video.
Summative Assessment
The students will complete the ATP Please! Quiz and key.
Formative Assessment
As described in Teaching Phase, the teacher will play a video titled "Powering the Cell: Mitochondria." The teacher will prompt the students to identify what is
occurring in the cell as the video progresses and follow up with specific answers.
page 2 of 3 Feedback to Students
Students will receive feedback from the teacher as the teacher circulates while the students are completing their worksheet to answer questions and keep the
students on track with the activity; the teacher will provide feedback during Case Study Activity. Teacher will use reflective questions to facilitate discussion while
students are completing their work: What do you think will happen in the muscles if there is no ATP? How important is the mitochondria? Could we survive with a
defective mitochondria? Why do we have both glycolysis and electron chain transport? Which is more important? How does energy transfer within the cell? What
process involves osmosis? What type of disease or illness could be caused by mitochondrial defects?
ACCOMMODATIONS & RECOMMENDATIONS
Accommodations:
Answering the questions in the ATP Synthesis Worksheet through inquiry of the figures may be a challenge for some. Offer a textbook to these struggling students to
help them understand the figures better.
Extensions:
1. For more advanced students, an alternative reading assignments can be assigned: http://www.medscape.com/viewarticle/828504 (also attached here as
"Joey's Case").
Suggested Technology: Computer for Presenter, Computers for Students, Internet Connection, LCD Projector, Overhead Projector
SOURCE AND ACCESS INFORMATION
Contributed by: Kettyna Bellabe
Name of Author/Source: Kettyna Bellabe
District/Organization of Contributor(s): Broward
Is this Resource freely Available? Yes
Access Privileges: Public
License: Attribution-NonCommercial 3.0 Unported
Related Standards
Name
SC.912.L.18.8:
SC.912.L.18.10:
Description
Identify the reactants, products, and basic functions of aerobic and anaerobic cellular respiration.
Connect the role of adenosine triphosphate (ATP) to energy transfers within a cell.
page 3 of 3