08023 updated alc liv diseasev3.qxp 28/5/08 16:08 Page 1 Alcohol and liver disease Fighting liver disease 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 Alcohol and liver disease The British Liver Trust works to: G support people with all kinds of liver disease G improve knowledge and understanding of the liver and related health issues G encourage and fund research into new treatments G lobby for better services. All our publications are reviewed by medical specialists and people living with liver disease. Our website provides information on all forms of adult liver disease and our Helpline gives advice and support on general and medical enquiries. Call us on 0800 652 7330 or visit www.britishlivertrust.org.uk 2 Page 2 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 Page 3 Contents The liver ..............................................................4 How liver disease develops ..................................5 Alcohol: could it be damaging your liver? ............7 What is alcohol? ..................................................9 How much can I drink? ......................................10 What is a unit of alcohol? ..................................12 What happens when you drink alcohol? ............16 What happens to the liver if you drink too much? ........................................................16 Who is at risk? ..................................................20 Can my liver recover? ........................................21 Effects of alcohol on the rest of your body ......................................................22 Will alcohol make me fat? ..................................23 The symptoms of alcoholic liver damage............24 Tests for alcoholic liver damage..........................26 Treatments ........................................................27 Diet ....................................................................28 Other treatments ................................................28 Liver transplants ................................................29 Drinking with other liver diseases ......................30 Who else can help?............................................31 Further information ............................................33 Fighting liver disease 3 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 The liver Your liver is your body's 'factory', carrying out hundreds of jobs that are vital to life. It is very tough and able to continue to function when most of it is damaged. It can also repair itself - even renewing large sections. Your liver has around 500 different functions. Importantly, it: 4 G fights infections and disease G destroys and deals with poisons and drugs G filters and cleans the blood G controls the amount of cholesterol G produces and maintains the balance of hormones G produces chemicals – enzymes and other proteins – responsible for most of the chemical reactions in the body, for example, blood clotting and repairing tissue G processes food once it has been digested G produces bile to help break down food in the gut G stores energy that can be used rapidly when the body needs it most G stores sugars, vitamins and minerals, including iron G repairs damage and renews itself. Page 4 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 Page 5 How liver disease develops Liver damage develops over time. Any inflammation of the liver is known as hepatitis, whether its cause is viral or not. A sudden inflammation of the liver is known as acute hepatitis. Where inflammation of the liver lasts longer than six months the condition is known as chronic hepatitis. Fibrosis is where scar tissue is formed in the inflamed liver. Fibrosis can take a variable time to develop. Although scar tissue is present the liver keeps on functioning quite well. Treating the cause of the inflammation may prevent the formation of further liver damage and may reverse some or all of the scarring. Fighting liver disease 5 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 Cirrhosis is where inflammation and fibrosis has spread throughout the liver and disrupts the shape and function of the liver. With cirrhosis, the scarring is more widespread and can show up on an ultrasound scan. Even at this stage, people can have no signs or symptoms of liver disease. Where the working capacity of liver cells has been badly impaired and they are unable to repair or renew the liver, permanent damage occurs. This permanent cell damage can lead to liver failure or liver cancer. All the chemicals and waste products that the liver has to deal with build up in the body. The liver is now so damaged that the whole body becomes poisoned by the waste products and this stage is known as end stage liver disease. In the final stages of liver disease the building up of waste products affects many organs. This is known as multiple organ failure. Where many organs are affected, death is likely to follow. 6 Page 6 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 Page 7 Alcohol: could it be damaging your liver? Most people think that alcohol is fairly harmless and just something to be enjoyed. Other than a few ill-effects the next day and maybe putting on a bit of extra weight, alcohol does not seem to have any long lasting effects. But alcohol can cause harm. Each year in the UK 150,000 people are admitted to hospital and 22,000 people die prematurely due to alcohol related causes. That death toll works out as 400 people every day. The cost to society has been estimated at over £20 billion. It is a mistake to think that you have to be a heavy drinker to run into problems. Although it can take as long as 10 to 20 years, drinking just a bit more than you should over time can seriously harm your liver. Not feeling any side effects from drinking does not mean that you are not risking chronic ill-health or lasting liver damage from alcohol-related liver disease. Vast numbers of us now fall into this category. The liver is your largest internal organ. Among hundreds of jobs, it has to deal with the alcohol you drink. If you’re drinking too much, your liver has to literally soak up the punishment. With so few nerve endings to signal pain you won’t know that your liver is complaining. If you’re drinking a lot on a regular basis, chances are that you will not feel anything happening until your liver has had enough. The harm to your liver at this stage will be severe – and could even be fatal. Fighting liver disease 7 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 This is not an attempt to put you off drinking. Being more sensible about how you drink is the aim. It can be easy to underestimate how much alcohol you are drinking and often difficult to stop after a certain number of drinks. A little more knowledge about alcohol itself will help. Taking a few minutes to read this leaflet to help you understand the effect alcohol has on you and your liver is a big step in the right direction. This leaflet is written to signpost the ways to safer drinking. It gives you short and long-term odds on the things that will go wrong if you ignore them. The message is simple: when you raise a glass, spare your liver a thought. If you keep track of how much you drink, you should stay in better shape and around for longer to enjoy it. 8 Page 8 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 Page 9 Jim’s story Jim is 55 years old. He used to visit his local pub most days to meet up with his mates. He had two to three pints at lunch and a couple of drinks in the evening (roughly 60 units of alcohol a week). Recently, over the course of a few weeks he noticed his abdomen had become swollen and tight. After tests, it was discovered that this was due to the build up of fluid (ascites), caused by cirrhosis of the liver. Jim took his doctor’s advice and has stopped drinking completely. After six months the fluid has gone and he is now feeling well and fitter, even though his liver will never fully recover. If he had continued drinking even a small amount, things could have been worse. Half of people with ascites die within two years of diagnosis. What is alcohol? Alcohol is derived from the fermentation of sugar by yeast. It is a drug. The main psychoactive ingredient in alcoholic drinks is ethanol, or ethyl alcohol. Ethanol dissolves quickly in water and is quickly absorbed into the bloodstream. In the short term, in small doses, it acts on receptors in the brain to make people feel uninhibited and provides a general sense of well-being. Drinking more alcohol starts to affect the balance and the speech centre of the brain. If you drink regularly, the brain’s receptors adapt to the alcohol and higher doses are needed to cause the same effect. Alcohol is a depressant. Rather than acting as a stimulant, alcohol is likely to have the opposite effect on people who drink heavily. Fighting liver disease 9 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 How much can I drink? If you are healthy and eat a balanced diet then sensible drinking should not give you problems. But what is sensible drinking? Women are more susceptible to liver damage than men, even if they drink less. Women are generally smaller than men. A greater proportion of their body mass is fat tissue which means they have less body water. This results in higher blood alcohol levels (blood alcohol concentration, or ‘BAC’) for each unit of alcohol they consume. The Department of Health currently offers the following guidelines for sensible drinking: G Women should not regularly drink more than 2 to 3 units of alcohol in a single day (no more than 14 units in a week) G Men should not regularly drink more than 3 to 4 units of alcohol in a single day (no more than 21 units in a week) G After an episode of heavy drinking it is advisable to stop drinking for 48 hours to allow your body to recover. This is not applicable for people who drink within the amounts recommended above. The British Liver Trust supports these guidelines. However, we advise you to avoid alcohol for a minimum of two consecutive days a week to give your liver a break. 10 Page 10 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 Page 11 When not to drink These occasions are generally well-known, but here’s a reminder. G Don’t drink alcohol when you’re taking medication. G Don’t drink alcohol if you need to drive or to operate machinery. Don’t use electrical equipment or touch circuitry. G Do not climb ladders or go near heights. G Don’t drink alcohol when taking part in sports activities, particularly contact or extreme sports. Never swim when you’ve drunk any amount of alcohol. G If you are pregnant, or planning to conceive. This is NHS guidance to minimise harm to your baby. Fighting liver disease 11 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 What is a unit of alcohol? One unit of alcohol is ten millilitres (ml) or eight grams (g) of pure alcohol. Units have been used for 25 years in the UK to describe amounts of alcohol. In the past, one unit could be identified as one drink. A unit was a measure of spirits, half a pint of beer, lager or cider (at 3.5% abv) or a small glass of wine at 9% abv. However, the alcohol content (abv) of drinks and the standard measures of drinks served have increased over time. This means the old rules of thumb about how much it is healthy to drink or to remain under the drink-driving limit no longer apply. Spirits used to be served in 25ml quantities, now it is often 35ml; wine used to be served in 125ml quantities, today it is usually in 175ml or even 250ml glasses. The strength of lager used to be 3.5% abv – now it is commonly 5% abv. If you’re partial to a particular beer or cider, be aware that abv might fluctuate between draught and canned or bottled versions. Non-draught can be significantly higher. The abv, which stands for ‘alcohol by volume’, is shown on the bottle, box or can. It tells you how many units there are in a litre, i.e. a strong beer at 6% abv means there are 6 units in a litre. If you drink half a litre (500ml or just under a pint) of beer at this strength, then you have had 3 units. A bottle of wine (750ml) at 14% abv will contain 10.5 units of alcohol. 12 Page 12 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 Page 13 Calculating units Calculating units is also complicated because we commonly use a mixture of imperial (pints) and metric (ml) units. There are a number of unit calculators available to help you overcome this from some of the organisations listed on pages 31 and 32. An accurate way of calculating how many units you are drinking is to multiply the abv figure by the size of your drink in millilitres and divide by 1,000. For example, a typical can of beer these days is 440ml, at 5% abv strength. Therefore: 440 x 5 = 2,200; divide this by 1,000 = 2.2 units. You can use this formula to work out other drinks: G a standard glass of wine (175ml) at 12% abv is 2.1 units and a large 250ml glass is 3 units G a measure (35ml) of spirits (40% abv) is 1.4 units G a bottle (275ml) of ordinary strength alcopops (5% abv) is 1.4 units G a ‘shot’ (35ml) of spirits, typically between 35% and 40% abv, is 1.3 units G a pint (568ml) of low strength (3.5-4% abv) beer or lager is 2.3 units G a pint of regular cider (alcohol 5% abv) is 3.4 units G a standard measure of port or sherry (50ml) is 1 unit. When you’ve worked out how many drinks you can have in one session, make this your target. Mixing non-alcoholic drinks in between is a good idea. Fighting liver disease 13 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 Binge drinking Binge drinking used to be thought of as getting drunk and staying drunk over an extended period of time, possibly days. This view is changing and is now more associated with shorter, more intensive drinking sprees (usually in one evening) where people intentionally get themselves very drunk. Binge drinking is also now regarded as a public health problem. But binge drinking often happens at home, at parties or other gatherings, particularly where there are frequent top-ups to glasses, a free bar or more supplies to hand from the cupboard or fridge. Wherever you are, when you drink a certain amount of alcohol – eight units for men and six for women – in one session, that counts as binge drinking. This is because drinking double the amount in the recommended guidelines in one day is an agreed definition of a ‘binge’. Many women are surprised to learn that consumption of two large glasses of wine over lunch or after work is classified as a binge. Remember, two large glasses of wine equals twothirds of a bottle. This shows just how easy it is to consume alcohol at a level which could be damaging to your health. Although statistics show that binge drinking is mostly seen in young people aged 16 to 24, many people in their thirties and older are also drinking at these levels. It is estimated that 12.5 million people drink more than the sensible drinking guidelines. 14 Page 14 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 Page 15 Just over a quarter of men drink more than 21 units and 15 per cent of women manage more than 14 units a week. What is a binge drink? Men: drinking more than 8 units in a single day e.g. 3 pints of beer or 2 large glasses of wine plus a double spirit Women: drinking more than 6 units in a single day e.g. 2 pints of beer or 2 large glasses of wine Drinking heavily over a short period leads to a rapid rise in blood alcohol and consequently to drunkenness. The effect on behaviour varies from one person to another. It ranges from relaxation and exhilaration to violent behaviour and coma. A rapidly rising blood alcohol level can make you reckless. You might say things or behave in a way that will embarrass you later. More ominously, it can lead to physical accidents, vehicle accidents (involving drivers, passengers or pedestrians), unsafe sex and leaving yourself vulnerable to rape or sexual assault. Very high blood alcohol levels can cause your brain's control over the respiratory system to paralyse, leading to heart irregularities, strokes and other potentially fatal occurrences. The scale of the problem is made clear by the number of people who end up in Accident and Emergency departments as a result of alcohol Fighting liver disease 15 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 related problems. These account for almost three quarters of all admissions from midnight until 5am at weekends, at an estimated annual cost to the National Health Service of £1.7 billion. What happens when you drink alcohol? Alcohol is quickly soaked up through the lining of the stomach and the upper part of the gut (intestine) and into your blood stream. The higher the concentration of alcohol, the faster it will be absorbed (whisky will be faster than beer, for example). From there, the alcohol is carried to your liver as well as other organs and body tissue. Your brain will be affected by the flow of alcohol which acts on the central nervous system to alter your physical coordination and mental judgement. Your liver cannot store alcohol. It metabolises (processes) about 90 per cent of the alcohol you drink to eliminate it from your body. It breaks down the alcohol into water, gas (carbon dioxide) and fat. What happens to the liver if you drink too much? Along with the central nervous system, the liver suffers the most from alcohol consumption. Your liver can only handle a certain amount of alcohol in any given time (one unit an hour). If you are drinking quickly, your liver cells will have to 16 Page 16 08023 updated alc liv diseasev3.qxp 28/5/08 16:08 Page 17 work overtime to process the alcohol. When this is more than the liver can deal with, the excess is transported to the rest of your organs. Your liver needs water to do its job. As alcohol acts as a diuretic (makes you pass urine), it dehydrates you and forces the liver to divert water from elsewhere.When the liver is processing alcohol it produces a substance called acetaldehyde. This has a toxic effect on the liver itself, as well as the brain and stomach lining. This is what causes your hangover. Acetaldehyde is subsequently broken down into a chemical called acetate, which is broken down further into carbon dioxide and water outside the liver. Regular and heavy drinking over time can strain or disrupt this process, leading to alcoholic liver disease. The first stage of disease may not seem all that significant but must be acted upon. The later stages are very serious and can threaten your life. Fatty liver When the liver breaks down alcohol, it stores the fat in your liver. There should be little or no fat in a healthy liver. Too much of this fat can build up if you drink more than the liver can cope with, leading to fatty liver disease. You can get a fatty liver without drinking. This is called, perhaps unoriginally, ‘nonalcoholic fatty liver disease’ (NAFLD). It is thought that if you are overweight and drinking too much, you will be increasing the chances of damaging your liver, as it receives fat from both food and alcohol. Fighting liver disease 17 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 Fatty livers return to normal if you drink within the sensible limit. If you carry on drinking above that limit you are running the risk of more serious damage. Alcoholic hepatitis If you have a fatty liver and continue to drink, you have up to a one in three chance of getting alcoholic hepatitis. This is a condition where your liver becomes puffy, swollen and tender. It can affect you suddenly – after a weekend of binge drinking, for example – and if your liver fails, it can kill you. Alcoholic hepatitis can happen to you at an early stage or after many years of excessive drinking. Henry’s story Henry is 35. He started drinking heavily with the Rugby Club at University and continued to see his friends at the pub where he drank up to five pints of strong lager three times a week (45 units of alcohol a week). Henry went on a ‘bender’ with friends abroad, drinking day and night for nearly a week. Afterwards he didn’t feel good and his friends noticed he looked a bit yellow. Henry’s doctor admitted him to hospital at once where he was treated for severe alcoholic hepatitis. Despite attempts to save him, Henry was among the one in 10 people who die despite treatment. Fibrosis Scar tissue, which is generated to protect injured tissue from further damage and will disappear in a healthy liver, may keep building up. This scarring is known as fibrosis. 18 Page 18 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 Page 19 Cirrhosis The final stage of alcoholic liver disease is cirrhosis. This is usually the result of long-term, continuous damage to the liver. Irregular bumps, known as nodules, replace the smooth liver tissue and the liver becomes harder. The effect of this, together with continued scarring from fibrosis, means that the liver will run out of healthy cells to support normal functions. This can lead to complete liver failure. By the time you discover you have cirrhosis your quality of life may be severely damaged as your liver will have stopped working efficiently. If you carry on drinking at this stage you will speed up the damage to your liver and rapidly increase your chances of dying. The odds are one in ten that you will develop cirrhosis if you drink too much over a long period of time. In the UK, the number of people dying from cirrhosis each year is increasing. As well as all the problems related to the liver not doing its job, people with cirrhosis also have a much higher chance of getting liver cancer. Each year, three to five per cent of people with cirrhosis will develop liver cancer. Fighting liver disease 19 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 Who is at risk? Everyone reacts to alcohol in different ways so it is difficult to tell in advance who is most likely to suffer liver damage. However, research shows that the following three groups may be more at risk than most: G women, partly because of their smaller body size and build G people who are overweight G people who inherit genes that don’t allow proper metabolism of alcohol. Studies suggest that immune response (how the body recognizes and defends itself against invading illness) may be a factor. This means that drinking alcohol triggers an aggressive physical reaction in some people that attacks their liver. This may explain why cirrhosis, unusually, can occur quite quickly in some drinkers. There are, of course, not only physical risks attached to excessive drinking. You may experience relationship problems with your family and friends, in your job and in many other social circumstances. You might also encounter financial difficulties. 20 Registered Charity No. 298858 © British Liver Trust 2005 Page 20 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 Page 21 Can my liver recover? What happens depends on how badly your liver is damaged and on your general health. If you have a fatty liver, you can help your liver to recover by stopping or cutting down on your drinking. If you have alcoholic hepatitis, most people can recover if they stop drinking completely (cutting down will only reduce the amount of damage done). But people with severe alcoholic hepatitis, who need to be admitted to hospital, have around a one in three chance of dying in the first month after admission. If you have cirrhosis, your liver cannot fully recover. But you can prevent any further damage being done to your liver and increase your survival rate if you stop drinking. If your liver is badly affected by cirrhosis and you continue to drink, it is estimated that you have only a one in three chance of living for five years. However, if you stop drinking, you can almost double your survival chances. Fighting liver disease 21 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 Effects of alcohol on the rest of your body Alcohol can damage any part of your body. As well as causing alcoholic liver disease, excessive drinking can lead to a number of other health problems, such as: 22 G stomach disorders G pancreatitis leading to diabetes G high blood pressure G heart problems, including heart attacks G strokes G vitamin deficiencies G sexual difficulties, including impotence G problems with the brain G depression G problems with nerves in the arms and legs G cancer of the liver, mouth, throat, gullet, large bowel (gut) and breast. Page 22 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 Page 23 Will alcohol make me fat? Alcohol contains a lot of calories, so drinking can make you fat. For example, even a small glass of wine (125ml) contains between 80 and 100 calories while a pint of draught beer at 3.5% abv may have up to 180 calories. Stronger ales and ciders will contain a great many more calories. Compare this to the daily calorie requirement of an average woman or man (2000 and 2500 calories respectively) and it is easy to see how you can put on weight by drinking alcohol. Additionally, the calories you consume from drinking are known as ‘empty calories’ because they give no nutritional value. Marianne’s story Marianne leads a stressful life. At the age of 45 she is juggling two kids and a busy job. She is used to unwinding most nights of the week with a bottle of white wine that she shares with her husband (22.5 units a week). During a check up, her doctor noticed signs that her liver was not normal and an ultrasound test showed a fatty liver. After three months without alcohol Marianne has lost weight and feels a lot healthier. Her liver has recovered and she is now able to have a drink now and then, but never has more than 14 units in one week. Fighting liver disease 23 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 The symptoms of alcoholic liver damage Your liver is tough. It can withstand years of damage by repairing itself and protecting the rest of your body. However, the liver is unable to signal real distress until it is in the end stages of liver failure, so that by the time you feel any symptoms of liver problems, the damage may be done. If you have alcoholic liver damage you may have some vague symptoms such as: G feeling some pain in the liver (place your right hand over the lower right hand side of your ribs and it will cover the area of your liver) G having a general feeling of poor health and fatigue G loss of appetite G a sick, nauseous feeling, especially in the mornings and often accompanied by diarrhoea. If you have any of the following specific symptoms, it is likely that your liver is already quite badly damaged with alcoholic hepatitis or cirrhosis and you should talk to your doctor at once. 24 G yellow eyes or, in more severe cases, yellow skin (jaundice) G vomiting blood (haematemesis) G dark black, tarry, stools (melena) G significant weight loss G periods of confusion or poor memory (hepatic encephalopathy) Page 24 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 G swelling of the abdomen or the ‘tummy’ area and legs G fever – possibly with shivering attacks G itching (pruritis). Page 25 If your doctor suspects you may have liver damage, he or she will look out for the following signs: G tender, firm, or possibly enlarged liver (hepatomegaly) G red and mottled palms (palpar erythema) G partly white fingernails (clubbing) G enlargement of the male breasts, which may be tender (gynaecomastia) G swollen abdomen (ascites) G thinning hair (alopecia) G weakness and wasting of the muscles (atrophy) G drink-related problems affecting your family relationships G drink-related problems affecting your work or career G drink-related financial problems G drinking that leads to trouble with authorities and/or the police. These are tell-tale signs that your drinking is out of hand and that you need some help. Fighting liver disease 25 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 Tests for alcoholic liver damage If your doctor suspects you have liver damage you may be sent to see a liver specialist (hepatologist) or a digestive disease specialist (gastroenterologist) for further tests. These tests may include: 26 G Blood tests, which among other things measure liver function and damage (liver function tests). G Scanning your liver with either an ultrasound, computerised tomography (CT) or magnetic resonance imaging (MRI) scan. G Performing a liver biopsy, in which a tiny piece of the liver is taken to be looked at under a microscope. A fine hollow needle is passed through the skin into the liver and a small sample is withdrawn. The test is usually done under local anaesthetic and may mean an overnight stay in hospital, although most people are allowed home later the same day if they live close by. G An endoscopy, in which a thin tube containing a tiny camera is passed down your gullet (oesophagus) and into your stomach. This is to check for extra veins in the oesophagus or stomach (varices) which may rupture and bleed spontaneously. Page 26 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 Page 27 Treatments Stop drinking The most effective way to treat alcoholic liver disease is to stop drinking. For most people with fatty liver and alcoholic hepatitis the liver will recover and heal itself if they stop drinking. Even if you have cirrhosis, you will reduce any further damage to your liver and increase your chances of survival if you stop drinking. If you cannot stop, try contacting one of the organisations listed on pages 31 and 32. If you have alcoholic liver damage, cutting down will only reduce the rate of damage. The symptoms of liver damage may disappear when you cut down the amount you drink, but this does not mean that damage is not taking place. Cirrhosis can develop even after drinking just a little too much over the years, with possibly no early warning signs of disease. Treatments are available that will alleviate the symptoms of cirrhosis, but they cannot reverse it. Fighting liver disease 27 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 Diet Drinking alcohol can lead to malnutrition. The consumption of empty calories, a loss of appetite and malabsorption (poor absorption of food nutrients) caused by alcohol’s toxic effect on the gut can all play a part in this. For this reason, eating well is important in helping your liver recover. If you have alcoholic liver damage it is likely that you lack vitamins, in particular thiamine (a B vitamin that helps the body convert carbohydrates into energy), and your doctor may have to prescribe vitamin supplements Other treatments If you have severe alcoholic hepatitis you may have to be admitted to hospital. Steroids (drugs used to control the inflammation of your liver) may be used if you are very ill and can improve your chance of survival from between 60 and 70 per cent to between 90 and 95 per cent if you are free of infection and have no internal bleeding from your gut. For people with alcoholic cirrhosis there is no specific treatment other than to stop drinking or, if available, undergo a liver transplant. This can only happen if you are a suitable ‘candidate’. 28 Page 28 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 Page 29 Liver transplants For some people with cirrhosis and/or lifethreatening liver complications, a transplant may be the only option. In the UK, alcoholic cirrhosis is the most common reason people need a liver transplant (and runs only second to hepatitis C in Europe as a whole). Only patients whose liver disease fails to improve after a period of abstinence (usually six months) are considered candidates for transplantation in the UK. If you are a candidate for a transplant you will be carefully assessed and may be put on the waiting list for a donor liver. If you continue to drink you will not be offered a transplant. If doctors consider that you need a liver transplant then you are unlikely to survive for more than a few years without one. A liver transplant is a major operation – after all, the liver is a major organ. One in twenty people do not survive the operation. If the transplant is successful you will need to take drugs for the rest of your life to stop your body rejecting the donor liver. Survival following a liver transplant is improving all the time, with about three quarters of those having a successful transplant now living longer than five years. If your liver transplant is alcohol-related, you will be required to abstain from alcohol permanently in order to remain in good health. Fighting liver disease 29 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 Drinking with other liver diseases Anyone with a liver condition should be very cautious about drinking alcohol, as there is strong evidence that this will make their condition worse. Drinking advice will vary from person to person, even among those with the same condition. Many people find they can no longer tolerate any alcohol while others might drink a small amount on special occasions. If you have any type of liver condition it is sensible to approach alcohol with caution or avoid it completely. If you are unsure whether it is right for you to drink, talk to your doctor. 30 Page 30 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 Page 31 Who else can help ? Alcohol Concern 64 Leman St London E1 8EU Tel: 020 7264 0510 E-mail: [email protected] www.alcoholconcern.org.uk A national agency on alcohol misuse, Alcohol Concern provides information on public policy issues affected by alcohol including public health, housing, children and families, crime and licensing. Al-Anon Family Groups UK & Eire 61 Great Dover Street London SE1 4YF Tel: 020 7403 0888 Email: [email protected] www.al-anonuk.org.uk Al-Anon Family Groups provide support to anyone whose life is, or has been, affected by someone else’s drinking. Alcoholics Anonymous General Service Office PO Box 1 Stonebow House Stonebow, York YO1 7NJ Tel: 01904 644026 Helpline: 0845 769755 www.alcoholics-anonymous.org.uk AA is the largest self-help group for people with alcohol problems. Anonymity is guaranteed. AA sees alcoholism as a disease which can be managed by abstinence and group support. Fighting liver disease 31 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 www.condomessentialwear.co.uk Helpline: 0800 567 123 A website and free helpline service promoting sexual health through information and prevention advice about sexually transmitted infections (STIs). www.drinkaware.co.uk A range of information, useful resources for sensible drinking and advice about alcohol from the Drinkaware Trust. Drinkline (The National Alcohol Helpline) Tel: 0800 917 8282 (open 9.00am to 11.00pm Monday to Friday) A free telephone helpline service offering information and self-help materials to callers worried about their own drinking, support for family and friends of heavy drinkers and advice on where to go for help. Frank (formerly the National Drugs Helpline) Tel: 0800 77 66 00 www.talktofrank.com A 24 hour free telephone service and website offering information and advice on drugs and drug misuse. A literature and referral service is also available to helpline callers. www.knowyourlimits.gov.uk Advice for young people aimed at reducing the risks to personal safety by making sensible choices when drinking alcohol. 32 Page 32 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 Page 33 Further information The British Liver Trust publishes a large range of leaflets about the liver and liver problems specially written for the general public. Titles you may find useful having read this leaflet include: G Cirrhosis and liver disease G Diet and liver disease G First steps: a guide to your liver G Liver disease tests explained G Liver transplantation Contact us for more information: Tel: 0800 652 7330 Email: [email protected] Web: www.britishlivertrust.org.uk This leaflet is for information only. Professional, medical and other advice should be obtained before acting on anything contained in the leaflet as no responsibility can be accepted by the British Liver Trust as a result of action taken or not taken because of the contents. Special thanks Professor Chris Day MA PhD MD FRCP Professor of Liver Medicine, Centre for Liver Research, University of Newcastle-upon-Tyne. Dr Jamie Barbour BSc (Hons) MBBS MRCP CME Specialist Registrar Gastroenterology, Newcastle-upon-Tyne Hospitals NHS Trust Fighting liver disease 33 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 Page 34 Can you make a difference? Liver disease is increasing alarmingly and the need to do more is greater than ever before… For the British Liver Trust to continue its support, information and research programme, we need your help. We raise funds from many sources and a large proportion is donated by voluntary contributions. If you would like to send a donation it will enable us to continue providing the services that people need. If you can help, please fill in the form on the page opposite. If you wish to help us further with our work by organising or participating in a fundraising event or becoming a “Friend of the British Liver Trust” please: Call us on 0800 652 7330 Email us at [email protected] Make a donation via our website at www.britishlivertrust.org.uk or write to British Liver Trust 2 Southampton Road Ringwood, BH24 1HY 34 28/5/08 16:09 Page 35 Ê 08023 updated alc liv diseasev3.qxp I enclose a cheque/postal order made payable to the British Liver Trust I wish to pay by credit card: MasterCard Visa CAF CharityCard Please debit my card with the sum of £ .................. Card No. ................................................................ Expiry date.............................................................. Name .................................................................... Address ................................................................ .............................................................................. ....................................Postcode ........................ Telephone ............................................................ Email...................................................................... Signature ..............................Date ........................ I am a tax payer and authorise the charity to reclaim the tax on my donation* Please send me your newsletter Please send me a list of information leaflets I am interested in leaving the Trust a legacy. Please send me more information I am interested in helping to raise awareness and funds in my local community. Please send me more information * You must pay an amount of income tax and/or capital gains tax equal to the amount the British Liver Trust will reclaim on your donation: which is equal to 28p for every £1 you donate. Your name and address will be added to our computer database ensuring you are sent the latest information. If you do not wish to receive further information, please tick here. Fighting liver disease 35 08023 updated alc liv diseasev3.qxp 28/5/08 16:09 This publication was produced with the support of an unrestricted grant from Diageo Great Britain. British Liver Trust 2 Southampton Road Ringwood, BH24 1HY Tel: 0800 652 7330 Fax: 01425 481335 Email: [email protected] Website: www.britishlivertrust.org.uk Registered Charity No. 298858 © British Liver Trust 2008 ALD/06/08 Page 36
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