Complications
Complex pedigrees
Inbreeding
Complications. Inbreeding
Thore Egeland(1),(2)
(1) Norwegian University of Life Sciences, (2) NIPH
[email protected]
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Complications
Complex pedigrees
Inbreeding
Beyond standard cases
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Complex pedigrees:
Large, incomplete (deficient), inbred. Later:
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Theta corrrection If e.g. Hardy-Weinberg does not apply
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Mutation If e.g. parent and child share no alleles
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Silent alleles Homozygote or silent allele?
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Drop out Homozygote or drop out?
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Complications
Complex pedigrees
Inbreeding
Important case, Exercise 2.3: Full - or half sibs?
H1: Full sibs
H2: Half−sibs
AF
AM
Bone
AS
AM
Bone
AS
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Complications
Complex pedigrees
Inbreeding
Input
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Recall: pedigrees specified by all parent-child relationships.
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Draw pedigree.
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“Bone” and “AS” full sibs left, half sibs right.
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Complications
Complex pedigrees
Inbreeding
Inbred example
202
201
203
101
102
2
3
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Complications
Complex pedigrees
Inbreeding
Case data
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Complications
Complex pedigrees
Inbreeding
Output
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Complications
Complex pedigrees
Inbreeding
Summary
I
I
Draw pedigree.
Identify:
Extra, untyped persons needed to define pedigrees.
Parent child relationships.
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Example Only 2 and 3 typed:
5 extra persons needed; 8 Parent child relationships.
202
201
203
101
102
2
3
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Complications
Complex pedigrees
Inbreeding
Summary
I
I
Draw pedigree.
Identify:
Extra, untyped persons needed to define pedigrees.
Parent child relationships.
I
Example Only 2 and 3 typed:
5 extra persons needed; 8 Parent child relationships.
202
201
203
101
102
2
3
8/8