Life Sciences Outlook Mexico . 2012 Driving scientific innovation Mexico A growing global pharmaceutical manufacturing market, bolstered by its geographic proximity to the United States Mexico Global trends The aftereffects of the recession, coupled with the European sovereign debt crisis, continue to plague business operations in the mature market clusters of North America and Western Europe, including those of life sciences companies of all sizes and maturity levels. Although most life sciences companies continue to enjoy higher profit margins than those of other industry segments, it has become markedly clear that the product development formula of the past no longer applies. As a result, greater emphasis is being placed on the next wave of drugs and treatments – those stemming from biological organisms. Additionally, companies are increasingly diversifying their portfolios to mitigate risk and help fund the lofty costs of innovation, adding generic brands, crop and animal science and even consumer products through mergers and acquisitions. New product developments have become ever more costly and difficult to achieve. Drug makers are attempting to achieve greater breakthroughs with less funds than in years past. The need to increase a company’s likelihood of developing a new treatment continues to steer conversations around location strategy. Although many companies maintain R&D in mature markets rich with people capital and renowned research universities, others are turning to emerging global clusters due to dedicated private and public funding. Mexico market overview The life sciences industry is currently estimated at MXN1.3 billion ($96.0 million),¹ or 2.4 percent of GDP, according to the Mexican Association of Pharmaceutical Research Industries (AMIIF). According to PricewaterhouseCoopers, the industry market value is estimated to reach MXN 17.3 billion ($1.3 billion)¹ by 2020. With growth projected upward of 12.0 percent, greater attention is being paid to regulation, safety and enhancements to the overall R&D and patent development processes. Mexico’s geographic proximity to the United States is a major factor in its anticipated growth. Several multinational companies have already moved certain operations to the county and additional investments are expected. Currently, about 200 companies have operations in Mexico, with the domestic production of drugs concentrated in Mexico City, State of Mexico, Puebla, Morelos and Jalisco states. According to KPMG's report on the local pharmaceutical industry, 85.0 percent of drug production occurs through the subsidiaries of multinational firms, and even though local companies have made efforts to improve on R&D and innovation, many still lack the ability to produce their own medicines and therefore rely on the experience of large multinationals. As such, life sciences companies in Mexico are largely responsible for the manufacturing, distribution and exportation aspects of the value chain. Given the large manufacturing presence in the country, improvements to healthcare programs to increase public access to drugs and enhancements to IP protection and regulatory framework are top of mind to support both consumer and business growth in the coming years. Outlook One of the greatest threats to Mexico’s growing life sciences industry is its rampant illegal market, currently estimated at MXN 1.3 billion ($100.0 million)¹ annually by the Pharmaceutical Industry National Chamber (Canifarma). Canifarma continues to emphasize the need to combat smuggling, piracy and the gaps in IP protection, realizing progress on all factors are needed to maintain and encourage further investment by foreign companies. 1 Six-month Industry statistics Mexico is a leading country in the Americas with regard to life sciences product production and consumption, and ranks ninth worldwide. Jones Lang LaSalle • Mexico • 2012 average conversion rate of 13.31 Mexican Pesos (MXN) per U.S. dollar, as of October 2012. 1.0 Researchers in science, per thousand total employment Graduate students in science, engineering manufacturing & construction, as a % of total graduate students 0.4% 25.6% Gross expenditure on R&D, as percent of GDP Total patent applications, residents only Sources: UNISCO Institute for Statistics, the World Bank 951 About Jones Lang LaSalle Jones Lang LaSalle (NYSE:JLL) is a financial and professional services firm specializing in real estate. The firm offers integrated services delivered by expert teams worldwide to clients seeking increased value by owning, occupying or investing in real estate. With 2011 global revenue of $3.6 billion, Jones Lang LaSalle serves clients in 70 countries from more than 1,000 locations worldwide, including 200 corporate offices. 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