rly to ea up ok v e Bo sa 500 d $ an 2nd Stem Cells for Drug Developers Overcoming the Practical & Scientific Challenges of iPSC & ESC Models 27th-29th March 2012, Boston Benefits of attending 18 expert speakers including • Understand the scientific mechanisms that control stem cell differentiation to generate homogenous cell populations which maintain the disease phenotype Lee Rubin Professor, Stem Cell & Regenerative Biology Harvard University • Examine whether iPS cells can be a valid substitution for ESCs and what their applications are for safety/toxicity testing Sandra Engle Senior Principal Scientist, Pluripotent Stem Cell Biology Pfizer • Discuss strategies to promote full maturation of stem cell-derived cell populations and advance your research efforts • Overcome challenges in stem cell production to make sufficient numbers for drug development • Learn new approaches to achieve validation of your assay • Harness the potential that iPS cells offer for individualized safety & efficacy screening Workshops: 27th March 2012 A)Developing Reproducible and Scalable Methods to Culture Stem Cells: From the Microwell Plate to the Bioreactor Jim Beltzer, Consultant, Beltzer Consulting Group B)Integrating a Chemical Toolbox in Pluripotent Stem Cell Systems to Advance Drug Development Programs: Emphasis on Small Molecule-Mediated Modulation of Cell Fate Dhruv Sareen, Director & Research Scientist I, iPSC Core Facility, Cedars-Sinai Regenerative Medicine Institute C)Understanding the Role of Stem Cell Factors and Functions to Aid Drug Discovery Efforts Ian Phillips, Norris Professor of Life Sciences & Director of the Center for Rare Disease Therapies, Keck Graduate Institute “Strong program, great speakers and a genuine focus on identifying solutions” “Outstanding…Excellent presentations, variety, very good organization, great networking sessions. Thanks for preparing and please repeat next year!” Novartis GlaxoSmithKline Tel: +44 (0) 203 141 8707 Email: [email protected] Rudolf Jaenisch Professor of Biology & Founding Member MIT & The Whitehead Institute Joe Reynolds Senior Scientist Merrimack Pharmaceuticals Mahendra Rao Director, Center for Regenerative Medicine NIH Christine Ivashchenko Principal Scientist GlaxoSmithKline Hirdesh Uppal Scientist Genentech Ole Isacson Professor of Neurology, & Director, Center for Neuroregeneration Research Harvard Medical School & McLean Hospital Jeff Dage Senior Research Advisor Eli Lilly Karen Chandross Director, Early to Candidate Unit Sanofi 2nd Stem Cells for Drug Developers Boston Benefits of attending Understanding complex disease mechanisms. Improving safety assessments. Identifying new drug targets. Drug developers universally indicate that stem cell-derived models will improve many aspects of the drug development process and save valuable time and money. So the rationale is simple, and the benefits are obvious. But it all comes back to HOW. How can the scientific and practical challenges be overcome to harness the full potential of stem cells? The 2nd Stem Cells for Drug Developers meeting will bring together the leading scientists from Pfizer, Harvard University, GlaxoSmithKline, McLean Hospital, Novartis, Genentech, The Whitehead Institute and Merrimack Pharmaceuticals to reveal how they are already using stem cells to add value to their discovery and development programs. Learn, network and discuss how to revolutionize your drug discovery and development efforts using stem cell-derived models. 1. Novartis, Merrimack Pharmaceuticals and Abbott will discuss how they are building stem cell models for use in drug screening and safety/toxicology assessments to understand the mechanisms of drug induced toxicity 2. Discover how iPSCs and ESCs can be used in disease research to increase your understanding of molecular disease mechanisms with The Whitehead Institute, McLean Hospital and The Medical College of Wisconsin 27th-29th March 2012 Hear what attendees said about our Stem Cells for Drug Developers meeting, April 2011: “Excellent overview of pharma’s interests and opportunities” Merck “This was a great event to gain insight into the broad approaches of stem cells in the drug discovery space” Beckman Coulter 3. GSK will outline their strategies to ensure in vitro maturation of iPSC – differentiated cardiomyocytes and Regeneron Pharmaceuticals will explore the use of 3D models to enhance functionality and morphology of ESC derived lineages 4. Find out how Eli Lilly, Pfizer, Sanofi and AVEO Pharmaceuticals are incorporating stem cells into their drug discovery activities for toxicity evaluation and to develop more predictive cellular assay systems 5. The NIH will discuss how to design a robust and scalable process to manufacture iPSC-derived motor neurons and achieve sufficient numbers for drug development purposes “Nicely balanced cross sections of the current state of stem cell applications” Pfizer 6. Learn how to differentiate stem cells more accurately by listening to how Harvard University and Wellstat Therapeutics are controlling stem cell fate into desired lineages 7. Cut through the hype and understand how Genentech, Pfizer, Novartis and GSK are already benefitting from using iPSCs in the R&D process 8. Gain valuable insight into how Johnson & Johnson is overcoming challenges to validate preclinical and clinical assays and avoid immunological pitfalls in assay development “Informative with fantastic networking opportunities, very well organized” Harvard University Who should attend? This meeting has been designed to provide cutting edge insights for drug developers to find the best way to incorporate stem cell-derived models into drug discovery & development. It’s also a fantastic occasion for companies currently focused on stem cell therapy to explore new opportunities and generate revenue in the near-term. From using stem cells in disease research to safety/toxicology assessment and recent breakthroughs in iPS cell technology, this meeting is for those involved in: • • • • • Stem cell biology & research Drug discovery & development Safety & toxicology assessment Disease research Target identification & validation • • • • • Genetic models Regenerative medicine Clinical strategy/development R&D strategy Commercial development “Excellent depth of information on the topic” Aldagen “Excellent content” BD Technologies Search groups for Stem Cells for Drug Discovery Forum to join the online community. Tel: +44 (0) 203 141 8707 Email: [email protected] 2nd Stem Cells for Drug Developers Keynote Session Panel Session Boston 27th-29th March 2012 Networking Session 28th March 2012 Day 1 08.00Registration, Coffee and Networking 08.55Chair’s Opening Remarks Ole Isacson, Professor of Neurology, & Director, Center for Neuroregeneration Research, Harvard Medical School & McLean Hospital Using Stem Cells To Model Disease 09.00iPS Cell Technology and Disease Research: Issues to be Resolved • Key issues using iPS cells for disease research and therapy including gene targeting • Quality of iPS and ES cells and reprogramming mechanisms Rudolf Jaenisch, Professor of Biology & Founding Member, MIT & The Whitehead Institute 09.30New Paradigms for Modeling Neurodegenerative Disease and Treatments with iPS Cells from Parkinson’s Disease Patients • Genetic and hereditary modeling of neurodegenerative diseases in human neurons in vitro • Overlapping cellular pathway and organelle dysfunction, with different genotypes causing the same disease • Rescue of cellular dysfunction by targeted actions of tool compounds Ole Isacson, Professor of Neurology, & Director, Center for Neuroregeneration Research, Harvard Medical School & McLean Hospital 10.00Modeling Neurodegenerative Diseases in a Dish • Data identifying molecular mechanisms of motor neuron loss in spinal muscular atrophy (SMA) stem cells • Data testing therapeutic compounds in SMA stem cells • Possible complications to using stem cell based assays for neurodegenerative diseases Allison Ebert, Assistant Professor, Department of Cell Biology, Medical College of Wisconsin 10.30Speed Networking Session and Morning Refreshments Overcoming Challenges In Using Stem Cells In Drug Discovery 12.00Novel Stem Cell Based Approaches to Modeling Cancer • Preclinical models for oncology and other disease areas • Discovery of predictive biomarkers in preclinical models • Translating preclinical discovery into clinical research Joerg Heyer, Director, Cancer Biology, AVEO Pharmaceuticals 12.30Integration of Human ESC/iPSC Derived Cells into Drug Discovery • Imperative for incorporating pluripotent stem cell derived cells into drug discovery and current applications • Gaps and future directions for use of pluripotent stem cell derived cells in drug discovery Sandra Engle, Senior Principal Scientist, Pluripotent Stem Cell Biology, Pfizer 1.00 Small Molecules to Stimulate Endogenous Repair in the Nervous System • Overview of the remyelination strategy and challenges • Data from an orally bioavailable, brain penetrable compound • Stimulation of human oligodendrocyte progenitor cell differentiation in vitro, in a concentration dependent manner Karen Chandross, Director, Early to Candidate Unit, Sanofi 1.30 Lunch and Networking Controlling Stem Cell Differentiation Into Desired Lineages 2.30 Increasing our Understanding of Signaling Pathways Involved in Stem Cell Differentiation to Advance Research Efforts • Differentiation protocols for ESCs and iPSCs • Enhancing efficiency of reprogramming Lee Rubin, Professor, Stem Cell & Regenerative Biology, Harvard University 3.00 Directed Differentiation of Stem Cells Co-Cultured with OP9-DL1 Cells into Engraftable T-Progenitors • OP9-DL1 cells induce the stage-specific differentiation of stem cells into T-lineage cells • Two human T-progenitor cell populations have been identified that exhibit rapid immune-engraftment within immunodeficient mouse models • Human T-progenitor cells differentiate into mature functional T cells Ross La Motte-Mohs, Senior Scientist, Wellstat Therapeutics 3.30 Afternoon Refreshments and Networking 4.00 DNA Methylation Dynamics in Stem Cells and Development • Methylation dynamics in early development • Epigenetic variation in stem cells • Non-CG methylation in stem and differentiated cells • Epigenetic reprogramming Alexander Meissner, Assistant Professor, Harvard Stem Cell Institute 4.30 Addressing the Gaps in Stem Cell Derived Models to Promote Wider Adoption in this Field • What are the limitations of current systems and how can stem cells enhance the predictivity of in vitro models? • Where do the knowledge gaps lie? Sandra Engle, Senior Principal Scientist, Pluripotent Stem Cell Biology, Pfizer, Gary Gintant, Senior Group Leader, Abbott, & Christine Ivashchenko, Principal Scientist, GSK 5.00 Chair’s Closing Remarks 7.00 Networking Dinner Share discussions with your peers and enjoy a relaxing and informal dinner in comfortable surroundings. Good food, good wine, good company! Tel: +44 (0) 203 141 8707 Email: [email protected] 2nd Stem Cells for Drug Developers Keynote Session Boston 27th-29th March 2012 Networking Session 29th March 2012 Day 2 08.00Registration, Coffee and Networking 08.55Chair’s Opening Remarks Gary Gintant, Senior Group Leader, Abbott Generating Fully Matured Cell Populations 09.00Strategies to Promote In Vitro Maturation of Stem CellDerived Cardiomyocytes • Functionality of in vitro hiPS-differentiated cardiomyocytes (hiPS-CM) • Equivalency of hiPS-CM to cells isolated from a mature organ • Strategies to promote hiPS-CM maturation • Genetic models and high content screening in hiPS- CM Christine Ivashchenko, Principal Scientist, GlaxoSmithKline 09.303D Culture Models for Tissue-Specific Stem Cells and Cancer Stem Cells, In Vivo and In Vitro • VelociGene platform allows for rapidly generating desired genetic modifications in mouse embryonic stem cells • Genetically modified mouse ES cells can be differentiated into desired lineages using in vitro and in vivo protocols • 3D culture models act as readouts for modulation of stemness and/or lineage specification Courtney M Williams, Scientist, Regeneron Pharmaceuticals Advances In Stem Cell Manufacturing 10.00Manufacturing Functional Motor Neurons from Human Pluripotent Stem Cells • Expansion and differentiation of neural cells • Designing a robust and scalable manufacturing process Mahendra Rao, Director, Center for Regenerative Medicine, NIH 10.30Morning Refreshments and Networking Stem Cells For Drug Screening & Safety/Toxicity Assessment 11.00Assessing Surrogates of Clinical Cardiotoxicity Using Stem Cell-Derived Cardiomyocytes • Demonstrate approach to preclinically assess drug safety using stem cell derived models • Understanding the mechanism of action of drug-induced cardiotoxicity • Translating preclinical toxicity results to the clinic Joe Reynolds, Senior Scientist, Merrimack Pharmaceuticals 11.30High-Throughput Screening Using Stem Cell-Based Models: Turning an Innovative Technology into a Transformative Approach to Drug Design • Stem cell-based approaches have the potential to revolutionize the practice of medicine • Many stem cell-related concepts are radically different from those of traditional R&D; therefore integrating them into today’s pharma culture raises a number of challenges • Developing stem cell-based projects inside a pharmaceutical company from disease modeling to high-throughput screening Arnaud Lacoste, Project Team Leader - Stem Cells & Regenerative Medicine, Novartis 12.00Lunch and Networking 1.15 Preclinical Assessment of Cardiac Safety/Toxicity Using Stem Cells: Strengths, Limitations & Future Possibilities • Advantages of cardiac stem cells in safety/toxicity screening • Assays and models presently used in pharma • Integration of stem cells in safety assessments and evolving strategies • What can we do better? Gary Gintant, Senior Group Leader, Abbott Comparing The Utility of ESCs & iPSCs 1.45 What are the Pros and Cons of Using ESCs and iPSCs and What are their Applications for Safety and Toxicity Assessment? • Advantages and disadvantages of ESCs and iPSCs • Comparing preclinical predictivity of stem cell-derived models with primary cell models • Stem cell technology application strategy in drug development: Cardiotoxicity, hematopoietic toxicity and hepatotoxicity Hirdesh Uppal, Scientist, Genentech 2.15 Afternoon Refreshments and Networking Ensuring Proper Assay Development 2.45 iPSC-Derived Neurons as a Physiologically Relevant Model for Drug Discovery • Role of cell models in drug discovery • Development and validation of an iPS derived neuronal cell model • Application of iPS derived neuronal models to drug discovery Jeff Dage, Senior Research Advisor, Eli Lilly 3.15 Developing and Validating Preclinical and Clinical Assays to Measure Immunological Response • Allogeneic versus xenogeneic modeling • Preclinical assay development: Learning the immunological pitfalls • Clinical immunogenicity monitoring • Considerations for clinical trials Sicco Popma, Principal Research Scientist, Stem Cell Organization, Johnson & Johnson 3.45 Chair’s Closing Remarks Tel: +44 (0) 203 141 8707 Email: [email protected] 2nd Stem Cells for Drug Developers Boston 27th-29th March 2012 Workshop A: Developing Reproducible and Scalable Methods to Culture Stem Cells: From the Microwell Plate to the Bioreactor Date: 27th March 2012 Time: 8.30am – 11.30am The culture of human embryonic stem cells (hESC) has begun to move from the research laboratory toward various clinical applications. These applications include: cell therapies, disease modeling and drug screening. Inherent to all of these applications is the need for reproducible and scalable culture methods that preserve the desirable traits of hESCs such as pluripotency, genetic stability, and growth rates. Attendees will explore and discuss: • Approaches to finding the right culture conditions to meet your needs • Matrix, media and cell line considerations for optimal growth and performance • Drivers for scale up, manufacturing concerns and potential bottlenecks • Bags, bioreactors, micro-carriers, hollow fiber and fixed bed bioreactors This course will describe the methods and the metrics that you will need to successfully scale your hESC cultures from microwell plates to multi-liter bioreactors. Workshop leader Jim Beltzer Consultant Beltzer Consulting Group Dr. Beltzer was the lead scientist for the research and development of Synthemax™ a synthetic growth surface for the culture of human embryonic stem cells at Corning Life Sciences. He was a co-founder of RETT Corporation and was a key player in the industrialization of several technology platforms including phage display and yeast two-hybrid. He has more than twenty years of industrial research and development experience in a broad range of disciplines. Workshop B: Integrating a Chemical Toolbox in Pluripotent Stem Cell Systems to Advance Drug Development Programs: Emphasis on Small Molecule-Mediated Modulation of Cell Fate As induced pluripotent stem cells can be differentiated to virtually any tissue in the body, they represent a new source of tissue for recreating human “disease-in-a-dish” models. These cells can address a significant bottleneck in drug development by providing physiologically-relevant functional human cell types in more predictive cellular assay systems. This has resulted in the identification of a multitude of functional small molecules involved in somatic/stem cell fate specification. Attendees will discuss and debate: • Current utilization of pluripotent stem cells (PSCs) in drug discovery • Challenges associated with current iPSC technology • Compounds currently involved in modulating PSC fate • Specification of various cell populations from PSCs • Characterizing small molecules using various approaches Attendees will leave this workshop with the tools they need to incorporate small molecules into their pluripotent stem cell research to advance their drug development programs. Workshop C: Understanding the Role of Stem Cell Factors and Functions to Aid Drug Discovery Efforts Stem cells not only have the potential to become therapies for disease, but they can also be used in vitro to aid in drug discovery and drug testing, saving companies time and money. Stem cells secrete growth factors that may be the source of their therapeutic effect and studying these factors could lead to new drugs. In addition microRNA regulates stem cells and specific inhibitors of stem cell microRNAs could become new drugs for regulating stem cell genes. This workshop will discuss: • In vitro use of human stem cells for drug toxicity studies • Paracrine hormones secreted by stem cells that may become drugs • Antisense (antagomirs) for specific microRNA that regulate stem cells Participants will leave this workshop with the knowledge they need to use stem cells to aid their drug discovery efforts. Tel: +44 (0) 203 141 8707 Email: [email protected] Date: 27th March 2012 Time: 12pm – 3pm Workshop leader Dhruv Sareen Director & Research Scientist I, Stem Cell Core Cedars-Sinai Medical Center Dhruv Sareen, Ph.D. is currently the Director of the Induced Pluripotent Stem Cell (iPSC) Core Facility and a Research Scientist at Cedars-Sinai Regenerative Medicine Institute. Dr. Sareen received his Ph.D. from the University of Wisconsin where he characterized novel pharmacological pathways of resveratrol-induced human tumor cell death and participated in its preclinical drug-development program. Now he is developing high-content screening tools using SMA patient iPSCs to discover novel therapeutic compounds. Date: 27th March 2012 Time: 3.30pm – 6.30pm Workshop leader Ian Phillips Norris Professor of Life Sciences & Director of the Center for Rare Disease Therapies Keck Graduate Institute Ian Phillips is the Norris Professor of Life Sciences and Director of the Center for Rare Disease Therapies at the Keck Graduate Institute in Claremont, California. He received his PhD and DSc in Pharmacology from the University of Birmingham. He was Chairman of Physiology at the University of Florida and Vice President of Research at the University of South Florida before he moved to KGI. 2nd Stem Cells for Drug Developers Boston 27th-29th March 2012 Speakers Karen Chandross Director, Early to Candidate Unit Sanofi Dr. Chandross supports the Early to Candidate Unit’s efforts to develop stimulators of endogenous tissue repair and global R&D regenerative medicine initiatives. She received her PhD at the Albert Einstein College of Medicine. Gary Gintant Senior Group Leader Abbott Gary Gintant is a Research Fellow in the Dept. of Integrative Pharmacology, Abbott Laboratories. He is involved in multiple internal and external drug discovery and safety initiatives, and serves on multiple journal editorial boards. Rudolf Jaenisch Professor of Biology & Founding Member MIT & The Whitehead Institute Rudolf Jaenisch is a Founding Member of the Whitehead Institute and a Professor of Biology at MIT. His laboratory is exploring the role of DNA modification, genomic imprinting and the nature of stem cells. Sicco Popma Principal Research Scientist, Stem Cell Organization Johnson & Johnson Sicco Popma is a Principal Research Scientist at the Stem Cell Organization of Johnson & Johnson. He directs preclinical and clinical stem cell immunology, bio-distribution, biomarker and drug delivery research. Hirdesh Uppal Scientist Genentech Hirdesh Uppal is a Scientist in Safety Assessment & Development Sciences at Genentech. He’s developing cutting edge stem cell technologies to harness the power of iPSCs to transform drug discovery and enable the promise of regenerative medicine. Jeff Dage Senior Research Advisor Eli Lilly Dr. Dage is a Senior Research Advisor at Eli Lily and Company. Through his leadership of the stem cell platform team, Dr. Dage is responsible for the evaluation and implementation of stem cell based research across drug discovery. Allison Ebert Assistant Professor, Department of Cell Biology Medical College of Wisconsin Dr. Ebert is an assistant professor in the Department of Cell Biology, Neurobiology and Anatomy at the Medical College of Wisconsin where she uses stem cells to model and potentially treat neurodegenerative diseases. Joerg Heyer Director, Cancer Biology AVEO Pharmaceuticals Dr. Heyer is heading AVEO Pharmaceuticals Genetic Models efforts supporting translational research and biomarker discovery for AVEO Pharmaceuticals drug discovery programs. Dr. Heyer received his Ph.D. at the Julius Maximilians University Wuerzburg. Ole Isacson Professor of Neurology, & Director, Center for Neuroregeneration Research Harvard Medical School & McLean Hospital Important recent scientific discoveries for neurological and psychiatric diseases made in Dr. Isacson’s lab through the use of ES and iPS cells show how to model disease, provide neuroprotection and how degenerated brain cell circuitry and synapses can be restored or replaced. Ross La Motte-Mohs Senior Scientist Wellstat Therapeutics Arnaud Lacoste Project Team Leader - Stem Cells & Regenerative Medicine Novartis Arnaud Lacoste is a Project Team Leader at Novartis where he pioneered the use of reprogramming technologies and patient-derived pluripotent stem cells for drug discovery and development. Dr. La Motte-Mohs is a Senior Scientist at Wellstat Therapeutics and his laboratory focuses on treating human T-immunodeficiency. He received his doctorate from the University of Illinois and completed postdoctoral studies at the University of Toronto. Joe Reynolds Senior Scientist Merrimack Pharmaceuticals Mahendra Rao Director, Center for Regenerative Medicine NIH Dr. Rao is internationally renowned for his research involving human embryonic stem cells (hESCs) and other somatic stem cells. He received his Ph.D. in developmental neurobiology from the California Institute of Technology. Courtney M Williams Scientist Regeneron Pharmaceuticals Courtney M. Williams is currently a Scientist in the Oncology and Angiogenesis group at Regeneron. Her work focuses on designing/ implementing in vitro cell culture systems for cancer stem cell target validation Joe is a Senior Scientist at Merrimack Pharmaceuticals in their Research and Development group working on the clinical candidate MM-302. He received his PhD from Boston University in Molecular, Cellular Biology and Biochemistry. Sandra Engle Senior Principal Scientist, Pluripotent Stem Cell Biology Pfizer Sandra Engle is a Senior Principal Scientist in the Pluripotent Stem Cell Biology Laboratory within Pfizer. Her lab focuses on generating iPSCs, differentiation of stem cells and the genetic modification of human stem cells. Christine Ivashchenko Principal Scientist GlaxoSmithKline Christine Ivashchenko is a principal scientist at GlaxoSmithKline pharmaceuticals. Her current research focus is on the use of stem-cell derived cardiomyocytes in the discovery of novel heart failure therapeutics. Alexander Meissner Assistant Professor Harvard Stem Cell Institute Alex Meissner joined Harvard University as assistant professor in the department of stem cell and regenerative biology. He is also a senior associate member of the Broad Institute. Lee Rubin Professor, Stem Cell & Regenerative Biology Harvard University Dr. Rubin is Professor of Stem Cell and Regenerative Biology at Harvard University. His lab uses stem cell-based screens to identify therapeutics for orphan neural disorders and explores different chemical biology approaches for manipulating cell fate. “The speaker array and order was perfect and allowed me to take the maximal amount of knowledge back to the lab” “Excellent state-of-the-art for in vitro technology and practical pharma examples. An extremely good snapshot of where the field is” Novartis Katya Tsaioun CSO Cyprotex Tel: +44 (0) 203 141 8707 Email: [email protected] 2nd Stem Cells for Drug Developers Sponsorship opportunities 27th-29th March 2012 Working with Hanson Wade If your organization needs to raise profile, promote products and services or develop new partnership opportunities in the stem cell sector, contact: Miles Harley Boston tel: +44 (0)20 3141 8700 email: [email protected] When you work with Hanson Wade you work with a partner focussed on your success. Your investment in both time and money needs to generate a return. Our clients want that too and that’s why they work with us. They want to reach a targeted audience and eliminate wastage from their marketing activities. They work with us because we deliver results. We’re proud of this fact. Our research identifies ground breaking issues and allows you to influence industry thinking at an early stage. Our expertise is recognised and respected by the industry. And our events are focussed, leading edge and attended by people looking for knowledge before making decisions. Attendee breakdown Attendee breakdown at the last meeting Seniority breakdown at the last meeting 14% 17% Scientist/Group Leader/Manager Large Pharma/Biotech 48% Academia 35% 51% Service Provider 35% Speaker Organizations Media Partners SCR StemCellResources.org the science of education Tel: +44 (0) 203 141 8707 Email: [email protected] Director Vice President 2nd Stem Cells for Drug Developers Boston 27th-29th March 2012 DSN Priority Code: Event prices Register Mail: Hanson Wade Charter House 13-15 Carteret St London, SW1H 9DJ Tel: +44 (0)20 3141 8707 Email: [email protected] Package Register and pay before Friday 20th January* Register and pay before Friday 10th February* Standard Price Conference + 3 workshops + Networking Dinner** $3596 (SAVE $500) $3696 (SAVE $400) $3796 (SAVE $300) Conference + 2 workshops + Networking Dinner** $3097 (SAVE $400) $3197 (SAVE $300) $3497 Please note that discounts are only valid when three or more delegates from one company book and pay at the same time. 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