CE L EB R AT E P RIN CE T O N
INV EN T I O N
2016
It takes a university…
Office of the Dean for Research
www.princeton.edu/research
91 Prospect Ave.
Princeton, NJ 08540
Tel.: 609-258-5500
[email protected]
To learn more about the researchers and
technologies in this brochure, contact:
John Ritter
Director, Technology Licensing
www.princeton.edu/patents
87 Prospect Ave., 3rd Floor
Princeton, NJ 08544
Tel.: 609-258-1001
[email protected]
For information on fostering industryfaculty collaborations, contact:
Coleen Burrus
Director, Corporate Engagement and
Foundation Relations
cefr.princeton.edu
91 Prospect Ave.
Princeton, NJ 08540
Tel.: 609-258-3277
[email protected]
For inquiries regarding
sponsored research, contact:
Jeff Friedland
Director, Research and Project
Administration
www.princeton.edu/orpa
87 Prospect Ave., 2nd Floor
Princeton, NJ 08544
Tel.: 609-258-3090
[email protected]
For more on entrepreneurship at
Princeton, contact:
Mung Chiang
Inaugural Chair, Princeton
Entrepreneurship Council
Director, Keller Center
entrepreneurs.princeton.edu
kellercenter.princeton.edu
Princeton Entrepreneurial Hub
34 Chambers St.
Princeton, NJ 08542
Tel.: 609-258-5071
[email protected]
I
f necessity is the mother of invention, then the university may be the
extended family that nurtures a discovery from its birth in a scientist’s
lab through its trying experimental phases on the path to becoming
a benefit to society. We often talk about this last stage, but it is an
invention’s infancy and early development that usually require the most
creativity and effort.
Those early days involve long
hours at the lab bench, sleepless
nights, false starts and do-overs,
and yet Princeton inventors choose
this path because they glimpse the
greater potential of their work.
They know — or at least they
hope — that the knowledge they
create or discover could treat a viral
illness for which we have no cure,
or help restore movement after a
stroke, or guard pacemakers against
malicious hackers. These faculty
members, postdoctoral researchers,
and graduate and undergraduate
students are inspired not only by
the drive to uncover knowledge but
also by the desire to contribute in
meaningful ways to societal and environmental well-being.
Each of these inventors knows that inspiration is not enough.
Invention stems not just from brilliant ideas and hard work but also
from luck and serendipity, and the ability to recognize an important
finding among data from an experiment that didn’t have the expected
result. At Princeton we are fortunate to be able to provide an
environment where all research can thrive, and individuals are afforded
the opportunity to dream the innovations of the future. We hope you
will join us as we celebrate the extended family of University researchers
who bring discoveries to life.
Pablo Debenedetti
Dean for Research
Class of 1950 Professor in Engineering and Applied Science
Professor of Chemical and Biological Engineering
Table of Contents
Featured Inventions 2016
8 Student-powered venture
Undergraduate startup brings
electricity to remote areas
3 A test for mitochondrial health
Ileana Cristea, Professor of Molecular
Biology
3 Adaptive cognitive prosthetic
Timothy Buschman, Assistant Professor
of Psychology and the Princeton
Neuroscience Institute
4 Securing implantable medical
devices against attack
Niraj Jha, Professor of Electrical
Engineering
5 Selective fluorination of drug
and PET imaging molecules
9 Princeton Plasma Physics
Laboratory spins off new
technologies
Inventions range from food
sterilization to bomb detection
10 Startup culture
Companies based on Princeton
innovations spark economic
activity
12 Bridging the gap
University discoveries receive
additional development to make
them ready for use
13 New ideas in the natural
sciences
Early-stage research projects
provide the seeds of innovation
14 Transformative technologies
Major impacts emerge from crossdisciplinary teams and diverse
perspectives
11 Collaborations with industry
Corporate engagement plays
an essential role in developing
University inventions into realworld technologies
John Groves, Hugh Stott Taylor Chair of
Chemistry
6 A fast and easy method for making
Janus nanoparticles
Rodney Priestley, Associate Professor of
Chemical and Biological Engineering
7 Small, fast and cost-efficient
flow sensors
Marcus Hultmark, Assistant Professor of
Mechanical and Aerospace Engineering
Inventors F Y16
15 Princeton faculty members and teams
A list of Princeton inventions by current and former members
of the University research community for fiscal year 2016
The Andlinger Center for Energy and the Environment
invention.princeton.edu
Celebrate Princeton Invention 2016 1
Addressing society’s most pressing challenges
R
esearch conducted in the laboratories at Princeton is aimed at answering
fundamental questions about life, the world around us and the universe beyond.
Sometimes this quest for understanding leads to technologies that can address
society’s most pressing challenges, such as helping patients recover from stroke or
improving the detection of cancer. When this synergy of basic and applied research
occurs, Princeton’s Office of Technology Licensing assists our faculty researchers
and their teams with the transfer of innovations to partners with the skills to further
develop them to the point where they can benefit our planet and society.
Our office continues to evolve as we respond to increased interest from our
University community to engage in technology transfer for the benefit of society.
Over the past year we have ramped up our capability to advise faculty and students
about startup ventures through the creation of a New Ventures position. Through such
activities, universities can stimulate economic growth in ways that provide new jobs,
livelihoods and sometimes the foundation of an entire industry.
Each year, Celebrate Princeton Invention gives us the opportunity to honor the
Princeton faculty, staff researchers and students who create new and transformative
technologies. Their efforts constitute one of the many ways in which Princeton fulfills
its mission of service to the nation and to humanity.
John Ritter
Director, Technology Licensing
“
Rapid changes to technology and
society are making the connections
between world-class research and the
innovation ecosystem more important
than ever. At Princeton, we are eager to
see those connections flourish, and our
students and faculty are enthusiastically
collaborating with both industry and
the nonprofit sector to discover and
implement ideas that will help address
the world’s challenges.
Christopher L. Eisgruber
President, Princeton University
2 Celebrate Princeton Invention 2016
”
“
Fundamental, curiosity-driven scientific
inquiry is at the heart of Princeton’s research
endeavors. This exploration of nature and
our place within it inspires and educates the
next generation of science and engineering
leaders and lays the groundwork for future
innovations. The quest for knowledge also
sometimes results in the discovery of new
technologies that, with further development,
can benefit humanity. Through Celebrate
Princeton Invention, we are proud to celebrate
the bold and groundbreaking work of our
faculty, postdoctoral researchers and students.
David S. Lee
Provost, Princeton University
”
invention.princeton.edu
Featured Inventions 2016
Invention
A test for mitochondrial health
Ileana Cristea, professor of molecular biology
What it does
T
he role of mitochondria — which are known as the power
plants of the cell — in human health is an active area of
research. A team led by Ileana Cristea is pioneering methods to
monitor and explore molecular regulators that have implications
for the research and treatment of mitochondrial diseases as well
as cancer, aging and viral infections.
Cristea’s research group has identified new enzymatic
activity by an important regulator of cellular energy production
known as sirtuin 4. The researchers demonstrated that
sirtuin 4 acts in mitochondria to turn off energy production by
inhibiting an important piece of the energy-making machinery,
the pyruvate dehydrogenase complex. Sirtuin 4 inhibits
pyruvate dehydrogenase activity through a process known as
delipoylation.
The team created an assay to accurately measure delipoylation
in cells or tissues, which can be used to monitor the activities of
sirtuin 4 and the pyruvate dehydrogenase complex. This assay
can be performed
in any type of cell,
tissue or patient
sample. The test
can help researchers
quickly assess the
activity of sirtuin 4
and discover ways
to inhibit it to boost
mitochondrial health,
or, alternatively,
activate the enzyme
to shut off harmful
mitochondrial activity.
Cristea noted that
stress, nutritional
deficiencies and
viral infections can
Ileana Cristea
destabilize sirtuin 4
functions and trigger
dysfunction in energy metabolism. An assay to detect sirtuin
4 could help researchers design therapeutic interventions that
restore mitochondrial health. Pyruvate dehydrogenase complex
deficiencies have been linked to severe mitochondrial diseases
that lead to intellectual disability, loss of balance and brain
malformation. Given the finding of the Cristea lab that sirtuin 4
regulates the activity of the pyruvate dehydrogenase complex,
these assays can provide a means for understanding the causes
of these diseases. Because mitochondria are found in every cell
and are fundamental to growth, the test also may aid in studies of
cancer, aging, cell signaling and viral infection.
invention.princeton.edu
Collaborators
Rommel Mathias, a former postdoctoral research fellow in
molecular biology; Todd Greco, associate research scholar
in molecular biology; Thomas Shenk, the James A. Elkins
Jr. Professor in the Life Sciences; and Adam Oberstein, a
postdoctoral research fellow in molecular biology.
Development status
Patent protection is pending. Princeton is seeking outside
interest for further development of this technology.
Funding source
National Institutes of Health
Invention
Adaptive cognitive prosthetic
Timothy Buschman, assistant professor of
psychology and the Princeton Neuroscience
Institute
What it does
T he adaptive cognitive prosthetic is a device that, when
implanted in the brain, helps recover cognitive function in
patients with a stroke or traumatic brain injury. The goal is to
restore or replace a
damaged brain region.
When a region of
the brain ceases to
function, the adaptive
cognitive prosthetic
will enable signals in
the brain to bypass
the damaged region to
restore functionality.
The device first
records the activity
of hundreds of
neurons that normally
feed instructions
to the damaged
region. The adaptive
cognitive prosthetic
then uses these
Timothy Buschman
readings and a novel
learning algorithm
to calculate instructions that can replace those that would have
traveled through the diseased region. The device delivers those
instructions to the appropriate region of the brain.
Such a device could help victims of stroke, trauma or other
brain injury. Stroke often involves the destruction of cells that
are needed to transmit signals from one part of the brain to
another. For example, the parietal cortex passes visual signals to
various areas of the brain that allow us to interpret what we see.
Damage to the parietal cortex can cause blindness in one half
Celebrate Princeton Invention 2016 3
of the individual’s normal field of view. To restore sight, the
adaptive cognitive prosthetic would identify the missing
signals, compute substitute instructions and deliver them to
other, intact regions.
Contributors
Sina Tafazoli, postdoctoral research associate in the Princeton
Neuroscience Institute; Cynthia Steinhardt, Class of 2016; and
Katherine Letai, Class of 2017.
Development status
Patent protection is pending. Princeton is seeking outside
interest for further development of this technology.
Funding source
National Institutes of Health
Invention
Securing implantable medical
devices against attack
Niraj Jha, professor of electrical engineering
What it does
I
n an increasingly connected world, a new technology
developed by Niraj Jha and his colleagues can provide
security for pacemakers, insulin pumps and other medical
devices that are at risk of being hacked.
Implantable and wearable medical devices that
communicate over wireless networks are vulnerable to attacks
that can either block communications altogether, or send
instructions to the device to cause harm, such as providing
an overdose of insulin or triggering an arrhythmia. Another
risk is from hackers who eavesdrop on the communications
to obtain private medical information. Encryption, the
typical security solution, uses significant amounts of power,
which keeps it from being added to these devices.
4 Celebrate Princeton Invention 2016
To enhance
medical-device
security — without
requiring the devices
to be upgraded — Jha
and his colleagues
developed a
technology
called MedMon
that monitors
communications
and, if it detects
unusual activity,
interrupts the transfer
of information.
MedMon is being
miniaturized so that it
Niraj Jha
can be worn on a belt
or carried in a pocket.
More recently, Jha and colleagues at Purdue University
developed a secure technology called SecureVibe that can be
incorporated into new medical devices. The new technology
consists of the addition of a secure channel of communication
that allows encrypted messages to be periodically sent between
the device and an external station with high energy efficiency.
Collaborators
MedMon: Meng Zhang, who earned his Ph.D. in electrical
engineering in 2013 and is now a member of the technical staff
at WorldQuant, and Anand Raghunathan, professor of electrical
and computer engineering at Purdue University.
SecureVibe: Younghyun Kim, Woo Suk Lee, Vijay Raghunathan
and Anand Raghunathan, all at Purdue University.
Development status
Patent protection is pending. Princeton is seeking outside
interest for further development of this technology.
Funding source
National Science Foundation
invention.princeton.edu
Invention
Selective fluorination of drug and
PET imaging molecules
John Groves, the Hugh Stott Taylor Chair
of Chemistry
What it does
T he invention is a method of adding fluorine to molecules for
use in imaging and therapeutics. Fluorinated molecules are
used as tracers that can detect cancer during positron emission
tomography (PET) scans. Fluorine also can be added to drugs
where the replacement of select hydrogen atoms with fluorine
atoms can improve a drug’s potency and potentially reduce side
effects. Until now, however, fluorination involved using toxic
and complicated fluorinating agents and a multistep process.
Groves and his collaborators invented new catalysts that
fluorinate molecules using safe-to-handle fluoride salts in a
single step. The technique is clean, fast and inexpensive, and
can be used to generate imaging molecules, drug candidates
and new agricultural chemicals.
The method involves the use of a manganese-based catalyst
that adds fluorine to sites on molecules that previously were
inaccessible by other techniques. The catalyst adds fluorine in
place of hydrogen in benzylic carbon-hydrogen bonds.
The new technique can be used to produce radioactive
18
F isotopes for use as tracer molecules — which emit particles
called positrons — that are detectable using PET scanning and
can pinpoint the locations of cancer in the body. The method
could also be used to add 18F to various molecules and then test
to see if certain attributes — such as specificity for cancer or
half-life — are improved.
Contributors
Wei Liu, who earned his Ph.D. in chemistry in 2014 and is now
a research associate at the University of California-Berkeley,
and Xiongyi Huang, who earned his Ph.D. in chemistry in 2016
and is now a research associate at the California Institute of
Technology.
Development status
Patent protection is pending. Princeton is seeking outside
interest for further development of this technology.
Funding sources
U.S. Department of Energy and the National Science Foundation
John Groves (back row, far right), with his laboratory team
invention.princeton.edu
Celebrate Princeton Invention 2016 5
Invention
A fast and easy method for making
Janus nanoparticles
Rodney Priestley, associate professor of chemical
and biological engineering
What it does
L Rodney Priestley
ike the two-faced Roman god for which they are named,
Janus particles have on their surfaces two physically distinct
regions with different functions. For example, Janus particles may
be hydrophobic on one side and hydrophilic on the other. Such
characteristics can enable new capabilities in drug delivery, medical
imaging, electronic displays and sensors, and as surfactants
in personal-care products.
Priestley and collaborator Robert Prud’homme, professor of
chemical and biological engineering, have developed a method
for the rapid and easy manufacture of nanoscale polymer Janus
particles. The method harnesses a technique developed by
Prud’homme and colleagues called Flash NanoPrecipitation. The
system involves rapidly mixing two polymers, one for each of
the two regions of the Janus particle, plus a solvent in a chamber.
The choice of solvent and polymers, combined with rapid mixing
in the chamber, enables the polymers to aggregate into particles
ranging from tens to hundreds of nanometers in length.
The ability to easily and rapidly produce the particles could
enable the more widespread use of Janus particles as amphiphiles,
which are chemicals that have both water- and oil-soluble
properties that make them ideal for use in personal and health
care products. Current methods of producing these particles
are cumbersome, requiring multistep procedures and lengthy
process times. The new technology has the potential to make Janus
particles on an industrial scale.
One potential use for large numbers of nanometer-scale
Janus particles is in highly stable foams and emulsions. Such
emulsions could be used to deliver active ingredients and to
enhance therapeutics, or as emulsifiers for agricultural chemicals.
Janus particles themselves also offer the possibility to serve as
bifunctional active components in personal health care products.
Priestley and his team are also investigating their use as nanoerasers in cleaning applications.
Collaborators
Robert Prud’homme, professor of chemical and biological
engineering; Chris Sosa and Vicki Lee, graduate students
in chemical and biological engineering; Rui Liu, a former
postdoctoral researcher at Princeton and professor at the School of
Materials Science and Engineering, Tongji University, Shanghai.
Development status
Patent protection is pending. Princeton is seeking outside interest
for further development of this technology.
Funding source
National Science Foundation
6 Celebrate Princeton Invention 2016
invention.princeton.edu
Marcus Hultmark (front row, second from left), with his laboratory team
Invention
Small, fast and cost-efficient
flow sensors
Marcus Hultmark, assistant professor of
mechanical and aerospace engineering
What it does
T he research team led by Marcus Hultmark has invented a suite
of nanoscale flow sensors to measure humidity, temperature
and velocity. The sensors’ small size and scalable manufacturing
could make them valuable for a variety of applications, such
as improving comfort levels in “smart homes,” sensing flow
parameters in automobile engines to improve performance, or
distributed monitoring of atmospheric conditions.
The sensors each consist of a micro-electromechanical
system (MEMS) device that can be produced using standard
semiconductor manufacturing techniques. Compared
to existing sensors, these are faster, smaller, simpler and
considerably cheaper. They consist of freestanding nanoscale
wire filaments strung across electrically conducting supports.
By incorporating effects of miniaturization both with respect
to fluid mechanics and heat transfer, the design of the sensing
elements can be tailored to the quantity measured. The sensors
are operated in different modes depending on which property is
measured. To measure humidity, the heated sensor’s sensitivity
invention.princeton.edu
to velocity can be decreased by using a wire that is only a
fraction of a micrometer in width. This means it loses heat
through conduction rather than convection via moving air.
Since thermal conductivity can be directly related to humidity,
the sensing element gives an accurate measurement of humidity.
Because it is insensitive to convection, the humidity sensor is
reliable even under conditions of moving air or fluid flow. If
instead the sensor is designed to favor convection, it can be
used to measure velocity.
In addition to velocity and humidity, these sensors can be
operated cold and be used to measure temperature at rates
much faster than conventional sensors. Together they form a
suite of sensors with unparalleled speed and resolution.
Collaborators
Yuyang Fan, Matthew Fu and Clayton Byers, graduate students
in mechanical and aerospace engineering; and Gilad Arwatz,
who earned his Ph.D. from Princeton in 2015 and is a former
postdoctoral researcher in Hultmark’s lab.
Development status
InstruMems, a startup venture led by Arwatz, has formed to
develop the humidity sensor into a functional prototype.
Funding sources
Princeton University and the Fondation pour l’Etude des Eaux
du Léman
Celebrate Princeton Invention 2016 7
Student-powered venture
Undergraduate startup brings electricity to remote areas
I t started as a class project to provide electricity to survivors
of the 2010 earthquakes in Haiti. Today, Princeton students
Angelo Campus and Aaron Schwartz are taking the concept
of “power in a box” to anyone who lives in remote areas poorly
served by the electrical grid.
Their product is BoxPower, a hybrid wind and solar-energy
system pre-assembled in a standard 20-foot shipping container.
The system can be transported anywhere in the world using
the global shipping infrastructure and set up in less than a
day without specialized tools or expertise. Once operational,
BoxPower can provide renewable electricity to supply up to six
families at roughly one-third of the cost of operating a dieselpowered generator.
“Because BoxPower requires no fuel purchases or significant
maintenance, it is an ideal solution for people who live in places
where it is difficult to get regular supplies,” said Campus, Class
of 2016. “BoxPower is much better for the environment than a
diesel generator, and much less expensive.”
Packed in each shipping container are solar panels, a wind
turbine, a battery bank and a small backup generator in case of
emergencies. When set up, the solar panels sit atop the box and
the wind turbine extends about 30 feet into the air using the
shipping container for support.
The team estimates that they can produce a BoxPower unit
for less than $40,000. They plan to conduct a pilot program in
collaboration with the Navajo Tribal Utility Authority to provide
power to households living without access to electricity. With
an estimated 2 billion people worldwide living without reliable
electrical power, the need for this system is considerable, said
Schwartz, Class of 2017.
“Our vision doesn’t stop at the local level,” Schwartz said.
“We imagine regional hubs of manufacturing and maintaining
BoxPower using the regional labor force.”
The BoxPower concept originated as a project called Powerin-a-BoxTM led by faculty members at Princeton including
Catherine Peters, professor of civil and environmental
engineering, and Elie Bou-Zeid, associate professor of civil and
environmental engineering, with support from the National
Science Foundation. Princeton students further developed the
concept in the course “Engineering Projects in Community
Service” and, through a 2012 national competition called “P3:
People, Prosperity and the Planet Student Design Competition
for Sustainability,” won a $90,000 grant from the U.S.
Environmental Protection Agency.
BoxPower has since been the recipient of several startup
competition awards including the 2016 U-Pitch New Jersey
Collegiate Business Model Competition; the 2016 New Jersey
Entrepreneurial Network Posters, Pitches and Prizes competition;
and the Princeton Social Innovation Competition.
Throughout the development of BoxPower, Schwartz and
Campus have received advice and support from Princeton’s
Keller Center. This spring, the students participated in the
Keller Center’s eLab Incubator program, which provides
access to advisers, workshops and workspace at Princeton’s
Entrepreneurial Hub. “The eLab Incubator program gave us
the opportunity to work with leading venture professionals
in a collaborative environment, and it is one of the really
special opportunities that we have as students at Princeton,”
Campus said.
Princeton undergraduates Aaron
Schwartz (left) and Angelo Campus
are taking the concept of “power
in a box” to remote areas poorly
served by the electrical grid. The
project has won several startup
awards, including from the 2016
U-Pitch New Jersey competition
(pictured).
8 Celebrate Princeton Invention 2016
invention.princeton.edu
Princeton Plasma Physics Laboratory spins off new technologies
Inventions range from food sterilization to bomb detection
L ocated three miles from Princeton University’s main
campus, the U.S. Department of Energy’s Princeton Plasma
Physics Laboratory (PPPL) is the nation’s premiere fusionenergy research center. It also is a wellspring of technological
innovations that have the potential to benefit society.
These technologies arise from the physics and engineering
research that scientists at PPPL, which is managed by
Princeton, conduct as part of the quest to develop fusion
energy, a safe and environmentally attractive method of
providing electricity using the same energy-generating process
that occurs in the sun. Through PPPL’s technology-transfer
office, promising discoveries can be transferred to private
industry, academic institutions and other federal laboratories
for development. “The technological discoveries that come
from magnetic fusion research find applications in areas
ranging from ones you might predict, such as aerospace and
defense, to ones that might surprise you, such as improved food
sterilization,” said Laurie Bagley, head of technology transfer,
patents and publications at PPPL.
Three of the technology spinoffs from PPPL are:
MINDS
Short for “Miniature Integrated Nuclear Detection System,”
MINDS is a cost-effective, compact technology for scanning
moving vehicles, luggage and other containers for signals
associated with radiological weapons, also sometimes called
dirty bombs. Developed by PPPL scientist Charles Gentile and
colleagues, MINDS could be deployed as a security measure at
airports, tollbooths, shipping ports, festivals and in subways and
other transportation systems to ensure public safety.
The technology detects several types of radioactive signals,
including X-rays, neutrons, and soft gamma and gamma
rays. The system recognizes distinctive energy signatures,
or “fingerprints,” and compares them to the energy spectra
associated with the radiological materials used in weapons.
Gentile’s collaborators include Andrew Carpe, PPPL technical
assistant; Steve Langish, PPPL technical supervisor; PPPL
software engineers Kenny Silber and Bill Davis; Dana Mastrovito,
a former PPPL software engineer who is now a doctoral student
at Rutgers University; and Jason Perry, who earned his master’s
degree in computer science from Princeton in 2004.
Egg pasteurization
A novel method for rapidly pasteurizing eggs in the shell
could enhance the safety of the United States’ food supply.
Current federal regulations do not require eggs sold in stores
to be pasteurized, yet these eggs are often consumed raw or
undercooked and cause more than 100,000 cases of salmonella
illness each year in the United States. Pasteurization of shell eggs
could reduce the number of salmonella cases by up to 85 percent,
according to the U.S. Department of Agriculture (USDA).
Researchers led by PPPL engineer Christopher Brunkhorst
developed a method of using radio-frequency energy to transmit
heat through the shell and pasteurize the yolk while the eggs
rotate in a stream of cool water that protects them against
invention.princeton.edu
Christopher Brunkhorst
overheating. Then, the eggs are bathed in hot water to ensure full
pasteurization of the yolk and white.
Brunkhorst collaborated with David Geveke, lead scientist
at the USDA Agricultural Research Service in Wyndmoor,
Pennsylvania, and Andrew Bigley, an engineering technician
recently retired from the USDA.
Advanced liquid centrifuge
Today’s centrifuges are the workhorses of science, used to
purify and separate everything from DNA to weapons-grade
uranium. Centrifuges also are used in industry to remove toxic
compounds from industrial wastewater, extract oil from oil sands
and even to clarify apple juice.
PPPL scientists led by Hantao Ji, professor of astrophysical
sciences at Princeton, have invented a new type of centrifuge that
can segregate a mixture of fluids into separate parts based on
differences in density, while also combining two or more fluids to
produce a uniform mixture or to enhance the rate of a chemical
reaction. The advanced liquid centrifuge accomplishes these
tasks by having both an inner cylinder and an outer cylinder that
rotate independently of each other to create a sheared flow in
the fluid. By injecting fluids at precise times and manipulating
the rotation speed of both cylinders, the centrifuge can mix
and then separate various ingredients without interruption in
ways that are not available in today’s single-cylinder centrifuges.
Ji collaborated with PPPL scientists Adam Cohen, Philip
Efthimion and Eric Edlund.
Celebrate Princeton Invention 2016 9
Startup culture
Companies based on Princeton innovations spark economic activity
R esearch can make a difference in everyday lives, especially
when university discoveries can be translated into
beneficial services through the entrepreneurial spirit of
a startup company. A number of startups based on Princeton
innovations represent a vibrant hub of economic activity.
Uniformity Labs
3-D printers have become a household name, but their
potential to transform industrial manufacturing has yet to
be realized. 3-D printing involves depositing a thin layer of
material — often a curable polymer or powder — on a surface
and applying energy to cure or fuse the material only in
selected locations, then repeating the process to build up a part
layer by layer.
To bring 3-D printing — also known as additive
manufacturing — to the industrial scale, California-based
Uniformity Labs is developing additive-manufacturing processes
that are faster, more efficient and less expensive than today’s
technologies.
“There is a lot of room for growth in production-scale
additive manufacturing of components in industries such
as aerospace, automotive technology, and energy and power
generation,” said Adam Hopkins, CEO of Uniformity Labs, who
earned his doctorate in chemistry and bachelor of arts in physics
from Princeton in 2012 and 2005, respectively. Uniformity Labs
is working to develop discoveries made in the laboratory of
Salvatore Torquato, professor of chemistry and the Princeton
Institute for the Science and Technology of Materials, and
Hopkins’ former adviser.
Torquato, Hopkins and their Princeton colleagues invented
technologies for making starting materials that are less porous,
and thus fuse more easily, than today’s materials. The research
on low-porosity materials, which was funded in part by the
National Science Foundation, could improve the quality of parts
made by printing in metal, ceramic, cement, plastic and glass,
among other materials. “We are developing technologies that are
required for additive manufacturing to achieve its full potential,”
Hopkins said.
10 Celebrate Princeton Invention 2016
GPB Scientific
The letters in the name GPB Scientific stand for “Getting
People Better,” according to founder and CEO Michael Grisham.
“We work to identify promising technologies and develop them
into innovations that can improve human health.”
One of these technologies originated in the Princeton
laboratories of James Sturm, the Stephen R. Forrest Professor in
Electrical Engineering, and Robert Austin, professor of physics.
In 2004, with electrical engineering graduate student Richard
Huang, the researchers published in Science a novel method for
separating biological molecules and living cells by running them
through a sort of microfluidic maze consisting of a silicon chip
small particle large particle
posts streamlines
dotted with pillars. As the cells migrated past the pillars, they
took different paths depending on their size. “The overall effect
is like a coin-sorter but for cells,” Grisham said.
GPB Scientific is using the technology to isolate tumor cells
from the blood to create a “liquid biopsy,” a non-invasive way
to detect and diagnose cancer. These cells originate in solid
tumors in the body’s organs and find their way into the blood. If
unchecked, they can spread, or metastasize, to other organs.
By isolating these tumor cells, which comprise just a tiny
fraction of the total number of cells in the blood, GPB Scientific
aims to provide clinicians with a way to diagnose cancer,
determine the correct course of treatment, and monitor a
patient’s progress. The research by Sturm and Austin enables
GPB Scientific to separate tumor cells gently and uniformly with
virtually no cell loss. The research was supported by the National
Cancer Institute, the National Science Foundation, the State of
New Jersey and the Defense Advanced Research Projects Agency.
This transfer of University-led research into a clinical
application would not be possible without the input of other
experts in oncology and cell biology, Grisham said. To provide
such expertise, GPB Scientific collaborates with Curt Civin,
director of the Center for Stem Cell Biology and Regenerative
Medicine at the University of Maryland School of Medicine.
“The real breakthroughs in technologies that benefit patients
and society at large come from scientists who know how to
collaborate with researchers at other institutions and in industry,”
Grisham said. “That is really special. That is where true
innovation comes from.”
invention.princeton.edu
FORGE Life Science
Despite some recent successes, many viral diseases have no
treatment, and most of the existing treatments target a specific
virus rather than being able to treat a broad spectrum of viruses.
Building on the discovery at Princeton of a family of human
proteins that naturally defend against viral infection, a startup
company called FORGE Life Science is working to develop
broad-spectrum antiviral compounds.
The company is building on research by professors Thomas
Shenk and Ileana Cristea demonstrating that proteins known as
sirtuins play a role in the body’s natural defenses, or intrinsic
immunity, against viruses. With funding from the National
Institutes of Health, Shenk, Princeton’s James A. Elkins Jr.
Professor in the Life Sciences, and Cristea, professor of molecular
biology, found that every member of the sirtuin family showed
the ability to inhibit viral replication.
Building upon that basic research, FORGE scientists are
looking for small molecules that modulate the activity of sirtuin
proteins to fight infection. They are initially targeting select
sirtuins, such as 1, 2 and 6, in different combinations to improve
the body’s ability to defend against viruses. Because sirtuins
inhibit more than one type of virus, a sirtuin-based therapeutic
could target multiple viruses.
“Our goal is to treat multiple viruses with one pill,” said
Lillian Chiang, FORGE Life Science’s President and CEO. “This
could change how we practice medicine.”
Such broad-spectrum capabilities are common in
antibacterial medicines, but to date, the few antiviral treatments
available are specific for certain viruses. With sirtuin-based
treatments, a doctor would not need to identify the virus, which
is time-consuming and expensive. Instead, the doctor could
prescribe a sirtuin-based drug based on the patient’s symptoms.
Sirtuin-based antivirals also could help treat the opportunistic
viruses that infect immunocompromised patients. The
antivirals would prevent virus replication even though the
X-ray structure of sirtuin modulator SirReal2 (magenta) bound
to Sirtuin 2 enzyme illustrates the feasibility of developing drugs
targeting sirtuin enzymes to effect antiviral activity.
immune system is actively suppressed, such as in cases where
patients have received organ transplants. Because some FORGE
drugs targeting sirtuins can cross the blood-brain barrier, the
technology also has the potential to provide treatments for
viruses such as rabies and measles. “We can potentially address
diseases for which we have no cure,” Chiang said.
Under Chiang’s leadership, FORGE Life Science is conducting
preclinical research. The company is located in Doylestown,
Pennsylvania. They’ve raised funds from the National Institutes
of Health’s Small Business Innovation Research program and
from private investors.
Collaborations with industry
Corporate engagement plays an essential role in developing University inventions
into real-world technologies
T he Dean for Research Innovation Fund for Industrial
Collaborations supports research collaborations that can
play an essential role in making the benefits of University
research available to the public. The fund requires industry
partners to provide matching funds and other opportunities to
speed the development of research projects with the potential for
societal benefit.
Securing the Internet of Things
Nick Feamster, professor of computer science and acting
director of the Center for Information Technology Policy, has been
invention.princeton.edu
awarded funding to work with Michael O’Reirdan of Comcast
Corporation in Philadelphia to enhance the security of the
Internet of Things (IoT). Many IoT devices, ranging from inhome cameras to medical implants, lack security features and a
user interface for modifying the device’s software. The project
aims to develop new mechanisms for improving IoT security,
including new machine-learning approaches to automatically
identify all of the devices connected to a user’s home network,
methods for detecting anomalous behavior, and the redesign of
IoT networks with an eye toward improving security so that if
one device becomes compromised it cannot infect others.
Celebrate Princeton Invention 2016 11
Bridging the gap
University discoveries receive additional development to make them ready for use
P rinceton’s Intellectual Property Accelerator Fund is
awarded annually by the Office of Technology Licensing
and supports projects with the potential to become
technologies or products that can benefit society.
Improved wireless communication
with photonics
With so many smartphones and other cellular devices
using today’s wireless spectrum, call and data quality can be
disrupted when signals interfere. To reduce this interference,
nearly all wireless devices contain a large number of filters,
switches and other components that take up a large amount of
space on the device’s circuit board that could instead be used
for functionality and performance.
A team led by Paul Prucnal, professor of electrical
engineering, is developing interference-canceling technology
that is cheaper, simpler and takes up less space inside the phone.
The technology involves a new type of computer chip that uses
light rather than electrons to process signals. The new processor,
called a photonic integrated circuit (PIC), can perform nearly all
the necessary communications functions at a fraction of the size
of today’s filters and switches. The processor can be made at low
cost using existing semiconductor manufacturing capabilities.
integrated-circuit technology, the team has created optical filters
as well as the necessary electronics to process fluorescent signals,
allowing the simultaneous detection of thousands of different
molecules.
New tactic for discovering more
effective antibiotics
Cheap and portable diagnostics
The ability to quickly diagnose diseases could enable health
care workers to respond rapidly to emerging pathogens,
improve patient outcomes and even change the course of an
outbreak. Assistant Professor of Electrical Engineering Kaushik
Sengupta and his team are developing a technology to detect
proteins and genetic material linked to human diseases in a
portable and low-cost biosensor that practitioners can use in
resource-limited settings.
Sengupta and his team have miniaturized a fluorescencebased system into a silicon-based technology that combines
complex optical and electronic components into a single
chip that can be manufactured at low cost. Using traditional
12 Celebrate Princeton Invention 2016
Bacteria that can resist antibiotics are a growing problem
worldwide, and new families of antibiotics are sorely needed.
Most clinical antibiotics in use today are derived from
compounds that bacteria produce to kill other bacteria. Yet
genomic research suggests that there are many more of these
antibacterial compounds waiting to be discovered, encoded in
rarely expressed “silent” or “cryptic” gene clusters.
Assistant Professor of Chemistry Mohammad Seyedsayamdost
and his team have invented a systematic method of mining these
silent gene clusters for new compounds by detecting molecular
signals that turn on gene expression in the clusters. The method
involves screening small-molecule libraries to find ones that
activate expression of the clusters, then evaluating the resulting
secreted product for antibiotic activity.
Antivirals against hepatitis B
Hepatitis B affects more than 2 billion people worldwide,
yet few patients receive adequate treatment and even fewer
are cured. Discoveries about the life cycle of this virus, which
establishes a chronic infection of the liver, have provided insight
on a new way to attack the virus.
Assistant Professor of Molecular Biology Alexander Ploss and
his team are working on a strategy to block the virus by targeting
enzymes in the human liver that help the virus replicate. The
researchers will explore factors that enable the virus to maintain
chronic infection, and screen libraries of small molecules to find
ones that can block factors essential for viral replication.
invention.princeton.edu
New ideas in the natural sciences
Early-stage research projects provide the seeds of innovation
P rinceton’s Dean for Research Innovation Fund for New
Ideas in the Natural Sciences supports high-quality, earlystage research.
A forensic approach to the
study of food webs
From buffalo to bacteria, living things coexist in networks
of interdependency known as food webs, but pinpointing
their structure has been difficult. A better understanding of
these networks could help manage the coexistence of wild and
domestic animals and preserve biodiversity.
Assistant Professor of Ecology and Evolutionary Biology
Robert Pringle and his team are using a forensic approach
to explore food webs by sequencing DNA fragments in fecal
samples of free-ranging African savanna animals to study their
diets and the symbiotic gut bacteria that aid digestion. The
goal is to characterize the food choices of animals — ranging
from cows to elephants and giraffes — and to explain how
differences in dietary preference enhance the ability of these
species to coexist.
the Henry DeWolf Smyth Professor of Physics, and Lyman Page,
the James S. McDonnell Distinguished University Professor in
Physics, along with colleagues from a dozen institutions around
the world, are designing a new telescope near the existing
Atacama Cosmology Telescope in northern Chile.
The new telescope will have 30-times more detectors than
its predecessor. However, it is not easy to pack 100,000 or
more detectors into the telescope’s two-meter-wide focal plane
while cooling the device to near absolute zero, a necessary step
when measuring such small temperature fluctuations. The
researchers will explore how to cool the device using numerous,
small hexagon-shaped cooling chambers, or cryostats, that
operate independently so that broken ones can be swapped out
if necessary.
New studies of the universe’s past
The cosmic microwave background — the tiny temperature
fluctuations in space left over from the Big Bang — offers a
window into the origin of the universe. To boost our ability to
measure these fluctuations, faculty members Suzanne Staggs,
A novel intervention to control
mosquito-borne diseases
With the Zika virus making headlines, international
attention has turned to the issue of controlling mosquitoes. Yet
traditional methods for limiting mosquito populations, such
as insecticides, have environmental costs and drive the rapid
evolution of resistance. If more were known about mosquito
mating behaviors, according to Associate Professor of Molecular
Biology Mala Murthy and Assistant Professor of Ecology and
Evolutionary Biology Carolyn McBride, both in the Princeton
Neuroscience Institute, it might be possible to intervene to
reduce mosquito populations.
The researchers will study sensory cues — acoustic, visual,
gustatory and pheromonal — in Aedes aegypti mosquitoes
that are important for courtship and mating, and look at the
underlying neural activity for these behaviors. The researchers
will use gene-editing technology to study neurons suspected of
driving olfactory and auditory behaviors, with the goal of finding
mosquito-control strategies.
invention.princeton.edu
Celebrate Princeton Invention 2016 13
Transformative technologies
Major impacts emerge from cross-disciplinary teams and diverse perspectives
S upporting promising research in the sciences and
engineering is the goal of Princeton’s Eric and Wendy
Schmidt Transformative Technology Fund. The fund,
endowed in 2009 by Eric Schmidt, executive chairman of Google
parent company Alphabet Inc., and his wife, Wendy, enables
research projects that have the potential to make a major impact
in a field of science or technology. Eric Schmidt is a 1976
graduate of Princeton and a former trustee of the University.
A technology to study how the infant
brain learns language
Interactions with caregivers are an important part of language
development in infants and young children, yet traditional MRIbased brain scanners can record only one person at a time and
don’t permit movement, a problem when studies involve infants.
Under the Schmidt Fund, Princeton researchers will work to
develop a safe and portable imaging system that can measure
neural activity in two brains simultaneously.
Led by Elise Piazza, an associate research scholar in the
Princeton Neuroscience Institute, the project will let researchers
study the neural underpinnings of human interaction, with a
focus on finding out what goes on in the brains of infants and
their caregivers during communication in natural settings.
Instead of functional magnetic resonance imaging (fMRI), the
system will use functional near-infrared spectroscopy (fNIRS),
which measures neural activity using low-intensity light
delivered via a cap worn on the head, allowing participants to
sit up and move naturally during communication.
“The ability to study communication in a natural setting
could revolutionize the study of how infants develop language
and shed light on what goes wrong in communication disorders
such as autism,” Piazza said. Her co-investigators are Uri
Hasson, associate professor of psychology and the Princeton
Neuroscience Institute, and Lauren Emberson and Casey LewWilliams, assistant professors of psychology and co-directors of
the Princeton Baby Lab.
Elise Piazza, Casey Lew-Williams, Uri Hasson and
Lauren Emberson
14 Celebrate Princeton Invention 2016
A microscope that can image and
manipulate a living cell
Researchers are designing and building a new type of
microscope that can view a living cell’s interior in 3-D
while simultaneously allowing investigators to manipulate
chromosomes and other internal structures in ways that were
previously impossible. The microscope will allow researchers
to address key mechanistic questions about how cells function,
which could lead to new discoveries about the cellular
missteps that lead to cancer, birth defects and other disorders.
The project brings together the expertise of faculty
members in biology, chemistry and physics. It is led by
Assistant Professor of Molecular Biology Sabine Petry
and Professor of Chemistry Haw Yang, together with
Joshua Shaevitz, associate professor of physics and the
Lewis-Sigler Institute for Integrative Genomics.
Current technologies for 3-D high-resolution imaging
typically require that cells be killed and fixed in place.
Methods for examining molecular activities inside the cell
tend to be conducted using large numbers of molecules. The
new microscope would fill a much-needed gap: an instrument
that can view the molecules and structures inside the cell in
real time. The new technology also will enable investigators
to push or pull on these structures using light in the form of
a laser, or using a new technology, developed by Yang, called
photon nudging.
This ability to manipulate structures inside a cell
while viewing the results with the microscope is entirely
new, Shaevitz said. “This technology would enable
researchers to explore the mechanical forces that we
know operate inside the cell but that we haven’t been
able to study directly,” he said.
Haw Yang, Joshua Shaevitz and Sabine Petry
invention.princeton.edu
Inventors FY16
A list of Princeton inventions by current and
former members of the University research
community for fiscal year 2016
The Production and Generation of Radionuclides From DeuteriumDeuterium (D-D) and Deuterium-Tritium (D-T) Moderated and
Non-Moderated Fusion Reactions for Medical, Industry and
Research Purposes (D)
George Ascione, Adam Cohen, Charles Gentile
Key: D = Disclosure A = Application P = Patent L = License
August, David
Faculty member or lead inventor
Trust Architecture and Related Methods (A)
Invention Title + Invention Status (D, A, P, L)
All inventors, alphabetical by last name
David August, Jordan Fix, Soumyadeep Ghosh
Austin, Robert
Aksay, Ilhan
Conducting Elastomers (A)
Ilhan Aksay, Kevin Sallah
Electrohydrodynamically Formed Structures of Carbonaceous
Material (A)
Ilhan Aksay, Valerie Alain-Rizzo, Michael Bozlar, David Bozym, Daniel
Dabbs, Nicholas Szamreta, Cem Ustundag
Graphene Dispersions (A)
High Efficiency Microfluidic Purification of Stem Cells to Improve
Transplants (A)
Robert Austin, Curt Civin, James Sturm
Methods and Devices for High Throughput Purification (A)
Robert Austin, Yu Chen, Curt Civin, Joseph D’Silva, James Sturm
Methods and Systems for Processing Particles (A)
Robert Austin, Yu Chen, Curt Civin, Joseph D’Silva, Michael Grisham,
James Sturm
Ilhan Aksay, Sezen Gurdag, Jeffrey Kaczmarczyk, Sibel Korkut Punckt,
Deniz Kormaz
Microfluidic System for Cell Processing Using Deterministic
Lateral Displacement Arrays for Cell Separation and Washing, and
an Incubator for Cell Incubation (D)
Printed Electronics (P)
Robert Austin, Yu Chen, James Sturm
Ilhan Aksay, Chuan-Hua Chen, Katherine Chiang, John Crain,
Sibel Korkut Punckt, John Lettow, Robert Prud’homme
Arnold, Craig
A Three-Dimensional (3-D) Tissue Scaffold With Cell
Alignment (D)
Craig Arnold, Stephen Bandini, Jeffrey Schwartz, Joshua Spechler
Design and Use of an Acoustically Tunable Beam Shaping
Apparatus (L)
Craig Arnold, Euan McLeod, Alexandre Mermillod-Blondin
Device for Harvesting Mechanical Energy Through a
Piezoelectrochemical Effect (A)
Craig Arnold, John Cannarella
Device for Mechanically Detecting Anomalous Battery
Operation (A)
Nanochannel Arrays and Their Preparation and Use for High
Throughput Macromolecular Analysis (A)
Robert Austin, Han Cao, Stephen Chou, Jonas Tegenfeldt, Zhaoning Yu
On-Chip Microfluidic Processing of Particles (A)
Robert Austin, Yu Chen, Curt Civin, Joseph D’Silva, Michael Grisham,
James Sturm
Post Geometry Designs for High Throughput Separation
of Nucleated Cells From Blood With Deterministic Lateral
Displacement Arrays (D)
Robert Austin, Joseph D’Silva, James Sturm
Post Geometry Designs for High Throughput Separation
of Nucleated Cells From Blood With Deterministic Lateral
Displacement Arrays (D, A)
Robert Austin, Joseph D’Silva, James Sturm
Craig Arnold, John Cannarella, Xinyi Liu
Electrolytes for Magnesium-Ion Batteries (A)
Avalos, José
Craig Arnold, Jake Herb, Carl Nist-Lund
Light Activated Gene Transcription of Metabolic Enzymes
for Metabolic Pathway Tuning and Induction of Promoter
Cascades (D)
Halide-Ion Free Electrolytes for Magnesium-Ion Batteries (D, A)
Craig Arnold, Jake Herb, Carl Nist-Lund
Ascione, George
Production of Radionuclide Molybdenum 99 in a Distributed and
In Situ Fashion (P)
George Ascione, Adam Cohen, Charles Gentile
invention.princeton.edu
José Avalos, Jared Toettcher, Evan Zhao
Optical Control of Transcription of Metabolic Enzymes for Tuning
of Engineered Metabolic Pathways and Induction of Promoter
Cascades (A)
José Avalos, Jared Toettcher, Evan Zhao
Celebrate Princeton Invention 2016 15
Back, Henning
Device and Method for Testing Underground Argon (A)
Henning Back
Barstow, Buz
Highly Complete, Non-Redundant Gene Disruption Collections (A)
Oluwakemi Adesina, Isao Anzai, Buz Barstow, Michael Baym, Lev Shaket
Knockout Sudoku: A Technology for Rapid, Low-Cost
Construction of Highly Complete, Non-Redundant Gene Disruption
Collections (D)
Oluwakemi Adesina, Isao Anzai, Buz Barstow, Michael Baym, Lev Shaket
Bassler, Bonnie
Heterocycle Analogs of CAI-1 as Agonists of Quorum Sensing in
Vibrio (A)
Bonnie Bassler, Lark Perez, Martin Semmelhack
Molecules and Compositions That Inhibit Gram Negative Bacteria
and Their Uses (A)
“
Merck is excited to continue our third
year of support for the Celebrate
Princeton Invention reception. We
value the event as a way to celebrate
recent successes in science with our
existing collaborators and build new
relationships across the research
ecosystem at Princeton.
”
Ian Davies
Executive Director, Chemistry, Merck & Co., Inc.
Bonnie Bassler, Knut Drescher, Laura Miller Conrad, Colleen O’Loughlin,
Martin Semmelhack, Albert Siryaporn
Novel Antimicrobial Compositions and Methods of Use (A)
Bonnie Bassler, Nina Hoyland-Kroghsbo, Jon Paczkowski
Small Molecule Antagonists of Bacterial Quorum-Sensing
Receptors (P)
Bonnie Bassler, Colleen O’Loughlin, Lee Swem, Scott Ulrich
Small Molecule Potentiation of Phage Antimicrobial Activity
for Use in Medical, Industrial, Agricultural, and Food Safety
Applications (D)
Bonnie Bassler, Nina Hoyland-Kroghsbo, Jon Paczkowski
Surfaces Comprising Attached Quorum Sensing Modulators (A)
Bonnie Bassler, Minyoung Kim, Tom Muir, Howard Stone, Aishan Zhao
Bernevig, B. Andrei
The Proper Geometry for Conical X-ray Crystal Spectrographs and
Novel Experimental Arrangements for the Spectroscopy of LaserProduced Plasmas and Other Small (Point-Like) X-ray Sources (D)
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill,
Novimir Pablant
Botstein, David
Systems for Induction of Gene Expression and Protein Depletion
in Yeast (P)
David Botstein, Robert McIsaac, Marcus Noyes, Sanford Silverman
Magnetic Topological Nanowires (A)
B. Andrei Bernevig, Ali Yazdani
Brangwynne, Clifford
Berry, II, Michael
Optogenetic Tool for Rapid and Reversible Clustering of
Proteins (D, A)
System and Methods for Facilitating Pattern Recognition (A)
Clifford Brangwynne, Yongdae Shin, Jared Toettcher
Michael Berry, II
Buschman, Timothy
Bitter, Manfred
A Multi-Cone X-ray Imaging Bragg Crystal Spectrometer (D, A)
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Lan Gao,
Kenneth Hill, Novimir Pablant
A New Class of Focusing Crystal Surfaces for the Bragg
Spectroscopy of High-Density Plasmas and Small (Point-Like)
X-ray Sources (A)
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill,
Novimir Pablant
A Novel Precise Proton Range Diagnostic for Proton Therapy
Treatment (D, A)
Manfred Bitter, Philip Efthimion, Lan Gao, Kenneth Hill, Dale Meade
Novel Objective for EUV Microscopy, EUV Lithography, and X-ray
Imaging (P)
Adaptive Cognitive Prosthetic and Applications Thereof (A)
Timothy Buschman
Carey, Jannette
A Method for Devising Protein Purification Protocols (D)
Jannette Carey, Anda Trifan, Patricia Weber
Carrow, Brad
Tri(1-Adamantyl)Phosphine and Applications Thereof (A)
Brad Carrow, Liye Chen
Tri(1-Adamantyl)Phosphine Ligand for Improved Transition Metal
Catalysis (D, L)
Brad Carrow, Liye Chen
Manfred Bitter, Philip Efthimion, Kenneth Hill
16 Celebrate Princeton Invention 2016
invention.princeton.edu
Carter, Emily
Multi-Color Light Emitting Diode and Intermediate Band Solar
Cells Based on Co-Ni Oxide (A)
Nima Alidoust, Emily Carter
Three Dimensional Hole Transport in Nickel Oxide by Alloying
With MgO or ZnO for Use as P-Type Transparent Conducting
Oxides (D, A)
Nima Alidoust, Emily Carter
Cava, Robert
Electronic Interconnects and Devices With Topological Surface
States and Methods for Fabricating Same (A)
Robert Cava, Nai-Phuan Ong, Ali Yazdani
Electronic Interconnects and Devices With Topological Surface
States and Methods for Fabricating Same (P)
Robert Cava, Nai-Phuan Ong, Ali Yazdani
Composite Nanoparticle Structures for Chemical and Biological
Sensing (A)
Stephen Chou, Wei Ding
Microfluidic Sensors With Enhanced Optical Signals (A)
Stephen Chou, Ruoming Peng, Chao Wang
Nanochannel Arrays and Their Preparation and Use for High
Throughput Macromolecular Analysis (A)
Robert Austin, Han Cao, Stephen Chou, Jonas Tegenfeldt, Zhaoning Yu
Plasmonic Nanocavity Array Sensors for Analyte Detection
Enhancement and Methods for Making and Using of the Same (A)
Hao Chen, Stephen Chou
Rapid and Sensitive Analyte Measurement Assay (A)
Stephen Chou, Liangcheng Zhou
Structures for Enhancement of Local Electric Field, Light
Absorption, Light Radiation, Material Detection and Methods for
Making and Using of the Same (A)
Gigantic Surface Lifetime of an Intrinsic Topological Insulator (A)
Stephen Chou, Wendi (Jason) Li
Robert Cava, M. Zahid Hasan, Madhab Neupane, SuYang Xu
Systems and Methods for Personalized Sample Analysis (A)
Uses of the Titanic Magneto-Resistance (XMR) in WTe2 and
Devices Based on the Effect as well as an Advanced Synthesis
Method for Making High Quality WTe2 Samples and Controlling
the XMR Effect (A)
Stephen Chou
Mazhar Ali, Zaheer Ali, Robert Cava
A Method for Measuring Low-Noise Acoustical Impulse Responses
at High Sampling Rate (A)
Caylor, Kelly
Solid Phase Extraction for Removal of Alcohols in Waters
Extracted From Plants (D, A)
Choueiri, Edgar
Braxton Boren, Edgar Choueiri, Rahulram Sridhar, Joseph Tylka
Loudspeakers With Position Tracking (D)
Edgar Choueiri, Anthony Hooley, Richard Topliss, Paul Windle
Kelly Caylor, Elliot Chang, Adam Wolf
Spectrally Uncolored Optimal Crosstalk Cancellation for Audio
Through Loudspeakers (P, L)
Chirik, Paul
Edgar Choueiri
Base Metal Catalyzed Borylation of Arenes and Aromatic
Heterocycles (A, L)
System and Method for Producing Head-Externalized 3-D Audio
Through Headphones (A, L)
Paul Chirik, Jennifer Obligacion, Margaret Scheuermann, Scott Semproni
Edgar Choueiri
Dehydrogenative Silylation and Crosslinking Using Pyridinediimine
Cobalt Carboxylate Catalysts (A)
Chyba, Christopher
Roy Aroop, Julie Boyer, Paul Chirik, Johannes Delis, Kenrick Lewis,
Christopher Schuster
Electric Power Generation From Earth’s Rotation Through Its Own
Magnetic Field (A)
Hydroboration and Borylation With Cobalt Catalysts (A)
Christopher Chyba, Kevin Hand
Paul Chirik, Tianning Diao, Renyuan (Pony) Yu
Iron and Cobalt Catalyzed Hydrogen Isotope Labeling of Organic
Compounds (A, L)
Paul Chirik, Renyuan (Pony) Yu
Chou, Stephen
Analyte Detection Enhancement by Targeted Immobilization,
Surface Amplification, and Pixelated Reading and Analysis (A)
Stephen Chou, Liangcheng Zhou
Assay Enhancement by Selective Deposition and Binding on
Amplification Structures (A)
Stephen Chou
Assay Structures and Enhancement by Selective Modification and
Binding on Amplification Structures (A)
Cohen, Adam
Production of Radionuclide Molybdenum 99 in a Distributed and
In Situ Fashion (P)
George Ascione, Adam Cohen, Charles Gentile
The Production and Generation of Radionuclides From DeuteriumDeuterium (D-D) and Deuterium-Tritium (D-T) Moderated and
Non-Moderated Fusion Reactions for Medical, Industry and
Research Purposes (D)
George Ascione, Adam Cohen, Charles Gentile
Cohen, Samuel
System and Method for Small, Clean, Steady-State Fusion
Reactors (A)
Matthew Chu Cheong, Samuel Cohen
Stephen Chou
invention.princeton.edu
Celebrate Princeton Invention 2016 17
Cristea, Ileana
Modulators of Sirtuins as Inhibitors of Human
Cytomegalovirus (A)
Ileana Cristea, Emre Koyuncu, Thomas Shenk
Sirt4 Lipoamidase Activity and Uses Thereof (A)
Ileana Cristea, Todd Greco, Rommel Mathias, Adam Oberstein,
Thomas Shenk
A New Class of Focusing Crystal Surfaces for the Bragg
Spectroscopy of High-Density Plasmas and Small (Point-Like)
X-ray Sources (A)
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill,
Novimir Pablant
A Novel Precise Proton Range Diagnostic for Proton Therapy
Treatment (D, A)
Manfred Bitter, Philip Efthimion, Lan Gao, Kenneth Hill, Dale Meade
Cuff, Paul
Novel Objective for EUV Microscopy, EUV Lithography, and
X-ray Imaging (P)
Root ORAM: Practical and Secure Random Access Memory (D, A)
Manfred Bitter, Philip Efthimion, Kenneth Hill
Paul Cuff, Prateek Mittal, Sameer Wagh
Dabbs, Daniel
Electrohydrodynamically Formed Structures of Carbonaceous
Material (A)
Ilhan Aksay, Valerie Alain-Rizzo, Michael Bozlar, David Bozym,
Daniel Dabbs, Nicholas Szamreta, Cem Ustundag
Plasma Incinerator System for the Reduction and Processing
of Bulk Materials (D)
Philip Efthimion, Charles Gentile, Kenneth Silber
The Proper Geometry for Conical X-ray Crystal Spectrographs and
Novel Experimental Arrangements for the Spectroscopy of LaserProduced Plasmas and Other Small (Point-Like) X-ray Sources (D)
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill,
Novimir Pablant
Darrow, Douglass
A Method of Choosing the Optimal Position, Orientation, and
Acceptance of a Fast Ion Loss Detector or Collector in a
Tokamak (D)
Douglass Darrow
Delgado-Aparicio, Luis
A Multi-Cone X-ray Imaging Bragg Crystal Spectrometer (D, A)
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Lan Gao,
Kenneth Hill, Novimir Pablant
A New Class of Focusing Crystal Surfaces for the Bragg
Spectroscopy of High-Density Plasmas and Small (Point-Like)
X-ray Sources (A)
Estes, Lyndon
Automated and Accurate Geometric and Radiometric Correction
of UAS-Collected Orthophotos (D, A)
Savannah Du, Lyndon Estes, Eric Principato
Feamster, Nick
Software Defined Internet Exchange Point (iSDX) (D)
Nick Feamster
Fisch, Nathaniel
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill,
Novimir Pablant
Controlling of Hot Spot Location of Compressing Gas via
Spinning (D)
The Proper Geometry for Conical X-ray Crystal Spectrographs and
Novel Experimental Arrangements for the Spectroscopy of LaserProduced Plasmas and Other Small (Point-Like) X-ray Sources (D)
Mass Separation by Neutral Polarization Effects (D)
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill,
Novimir Pablant
Mass Separation Through Biased Drifts in Collision Gradients (D)
Nathaniel Fisch, Vasily Geyko
Nathaniel Fisch, Ian Ochs
Nathaniel Fisch, Ian Ochs
Dogariu, Arthur
Detection Systems and Methods Using Coherent Anti-Stokes
Raman Spectroscopy (P)
X-ray Burst Generation and Control Through Sudden Viscous
Dissipation in Compressing Plasma (D)
Seth Davidovits, Nathaniel Fisch
Arthur Dogariu
Systems and Methods for Lasing From a Molecular Gas (P)
Arthur Dogariu, James Michael, Richard Miles
Dong, John
Automated Testing Instrument for Verification of Complex
Computational Systems (D, A)
Fleischer, Jason
Method and Apparatus for Enhancement of Ultrasound Images by
Selective Differencing (A)
Jason Fleischer, Jen-Tang Lu
Quantum Information Processing and Computation via Direct
Imaging (D)
John Dong, Hans Schneider, Gretchen Zimmer
Jason Fleischer, Chien-Hung Lu, Matthew Reichert, Xiaohang Sun
Efthimion, Philip
Florescu, Marian
A Multi-Cone X-ray Imaging Bragg Crystal Spectrometer (D, A)
Non-Crystalline Materials Having Complete Photonic, Electric or
Phononic Band Gaps (A)
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Lan Gao,
Kenneth Hill, Novimir Pablant
18 Celebrate Princeton Invention 2016
Marian Florescu, Paul Steinhardt, Salvatore Torquato
invention.princeton.edu
“
Gao, Lan
A Multi-Cone X-ray Imaging Bragg Crystal Spectrometer (D, A)
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Lan Gao,
Kenneth Hill, Novimir Pablant
The Office of Technology Licensing is
a force that gives Princeton’s faculty
and students the confidence to pursue
entrepreneurship and technology
transfer. These areas are very different
than scholarly research, but essential
for realizing its impact. The office is
a bridge between the way scholarly
research is done at Princeton and the
practical realities — both bureaucratic
and legal — of technology transfer.
Naveen Verma
Associate Professor of Electrical Engineering
”
Non-Crystalline Materials Having Complete Photonic, Electronic
or Phononic Bandgaps (P)
Marian Florescu, Paul Steinhardt, Salvatore Torquato
Floudas, Christodoulos
Methods of Separating Molecules (A)
Eric First, Christodoulos Floudas, M. M. Faruque Hasan
Forrest, Stephen
High Efficiency Organic Photovoltaic Cells Employing Hybridized
Mixed-Planar Heterojunctions (P)
A Novel Precise Proton Range Diagnostic for Proton Therapy
Treatment (D, A)
Manfred Bitter, Philip Efthimion, Lan Gao, Kenneth Hill, Dale Meade
Garcia, Benjamin
Sequence-Specific Extraction and Analysis of DNA-Bound
Proteins (P)
Johannes Dapprich, Benjamin Garcia, Gary LeRoy
Gelperin, Alan
Sphere of Life (D)
Alan Gelperin
Gentile, Charles
Plasma Incinerator System for the Reduction and Processing of
Bulk Materials (D)
Philip Efthimion, Charles Gentile, Kenneth Silber
Production of Radionuclide Molybdenum 99 in a Distributed and
In Situ Fashion (P)
George Ascione, Adam Cohen, Charles Gentile
The Production and Generation of Radionuclides From DeuteriumDeuterium (D-D) and Deuterium-Tritium (D-T) Moderated and
Non-Moderated Fusion Reactions for Medical, Industry and
Research Purposes (D)
George Ascione, Adam Cohen, Charles Gentile
Transition-Edge Sensor X-ray Fluorescence (TES-XRF) for High
Resolution Material Identification (D, A)
Charles Gentile, Christopher Tully
Gerakis, Alexandros
Active Protection of Optical Surfaces From Contaminations (D)
Stephen Forrest, Barry Rand, Soichi Uchida, Jiangeng Xue
Alexandros Gerakis, Alexsandr Merzhevskiy, Yevgeny Raitses,
Vladislav Vekselman
Freedman, Michael
Car Seat/Cabin Ejection System for Autonomous Road
Vehicles (D)
System and Method for Improving Streaming Video via Better
Buffer Management (D, A)
Alexandros Gerakis
Matvey Arye, Michael Freedman
Gitai, Zemer
Galbiati, Cristiano
Detector, Three-Dimensional Direct Positron Imaging Unit,
and Method to Estimate the Differential of the Radiation
Dose Provided to Cancer Cells and Healthy Tissues During
Hadrotherapy (D, A)
Cristiano Galbiati
Compounds Having Antibacterial Activity and Methods of Use (A)
Zemer Gitai, Hahn Kim, Maxwell Wilson
Inhibiting the Colonization, Growth and Dispersal of Pathogenic
Bacteria in Healthcare Devices and Patients Through Surface
Chemistry Treatments and Fluid Flow Control (A)
Zemer Gitai, Minyoung Kim, Yi Shen, Albert Siryaporn, Howard Stone
Gammie, Alison
Synthetic Lethal Targeting of Mismatch Repair Defective Cells (A)
Regulation of Pathogenic Virulence by Surface Mechanical
Properties (A)
Alison Gammie, Hahn Kim, Irene Ojini
Zemer Gitai, Sherry Kuchma, George O’Toole, Albert Siryaporn
invention.princeton.edu
Celebrate Princeton Invention 2016 19
Gmachl, Claire
High Peak Power Quantum Cascade Superluminescent
Emitter (A)
Nyan Aung, Claire Gmachl, Mei Chai Zheng
Single-Mode Quantum Cascade Lasers With Enhanced Tuning
Range (P)
Novel Objective for EUV Microscopy, EUV Lithography and X-ray
Imaging (P)
Manfred Bitter, Philip Efthimion, Kenneth Hill
The Proper Geometry for Conical X-ray Crystal Spectrographs and
Novel Experimental Arrangements for the Spectroscopy of LaserProduced Plasmas and Other Small (Point-Like) X-ray Sources (D)
Claire Gmachl, Peter Liu, Mei Chai Zheng
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill,
Novimir Pablant
Gomez, Michael
Hultmark, Marcus
Self-Aligning Mirror Mechanism for Transmission Line Offset
Correction (D, A)
Bending Beam Velocity Sensor (D, A)
Cara Bagley, Michael Gomez, Benjamin Tobias, Ali Zolfaghari
Groves, John
A Method for Efficient, One-Step, Fluorination of Bio-Active
Molecules and Building Blocks Using Fluoride Ion and a
Non-Heme Manganese Catalyst (D)
Xinyi Chen, John Groves
Clayton Byers, Yuyang Fan, Matthew Fu, Marcus Hultmark
Bending Filament Velocity Sensor (A)
Clayton Byers, Yuyang Fan, Matthew Fu, Marcus Hultmark
Elastic Filament Velocity Sensor (A)
Clayton Byers, Yuyang Fan, Matthew Fu, Marcus Hultmark
Fast Response Humidity Sensor (L)
Gilad Arwatz, Yuyang Fan, Marcus Hultmark, Margit Vallikivi
C-Halogen Bond Formation (A)
Fast Response Temperature Sensor (A, L)
John Groves, Xiongyi Huang, Wei Liu
Gilad Arwatz, Carla Bahri, Yuyang Fan, Marcus Hultmark
Compositions and Methods for Hydrocarbon Functionalization (A)
Liquid-Infused Surfaces Featuring Reduced Drag Characteristics,
and Methods for Fabricating the Same (A)
Nicholas Boaz, George Fortman, John Groves, Thomas Brent Gunnoe
Iron Porphyrazines as Efficient, Catalytic and Scalable Method
to Produce Chlorine Dioxide (A)
John Groves, Roy Xiao
Matthew Fu, Marcus Hultmark, Ian Jacobi, Brian Rosenberg, Alexander
Smits, Howard Stone, Jason Wexler
Nanowires Integration for Real-Time Compensation (A, L)
Gilad Arwatz, Marcus Hultmark
Isotopic Fluorination and Applications Thereof (A)
Xinyi Chen, John Groves
Targeted, Metal-Catalyzed Fluorination of Complex Compounds
With Fluoride Ion via Decarboxylation (A)
John Groves, Xiongyi Huang
Hasan, M. Zahid
Gigantic Surface Lifetime of an Intrinsic Topological Insulator (A)
Jaworski, Michael
Concept for Reducing Hall Thruster Chamber Wall Erosion With
Lithium Vapor Shielding (A)
Michael Jaworski, Igor Kaganovich, Robert Kaita, Yevgeny Raitses
Electrical Detector for Liquid Metal Leaks (A)
Michael Jaworski, Jacob Schwartz
Robert Cava, M. Zahid Hasan, Madhab Neupane, SuYang Xu
Use of Liquid Electrodes for Magnetohydrodynamic Power
Generation Applications (A)
Method for Production and Identification of Weyl Semimetal (A)
Michael Jaworski
Nasser Alidoust, Ilya Belopolski, M. Zahid Hasan, Shuang Jia, Madhab
Neupane, SuYang Xu
Jha, Niraj
Methods to Make and Identify a Weyl Semimetal (D)
CABA: Continuous Authentication Based on BioAura (D, A)
Nasser Alidoust, Ilya Belopolski, M. Zahid Hasan, Shuang Jia, Madhab
Neupane, SuYang Xu
Niraj Jha, Arsalan Nia, Anand Raghunathan, Susmita Sur-Kolay
Hill, Kenneth
A Multi-Cone X-ray Imaging Bragg Crystal Spectrometer (D, A)
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Lan Gao,
Kenneth Hill, Novimir Pablant
A New Class of Focusing Crystal Surfaces for the Bragg
Spectroscopy of High-Density Plasmas and Small (Point-Like)
X-ray Sources (A)
Fine-Grain Dynamically Reconfigurable FPGA Architecture (A)
Niraj Jha, Ting-Jung Lin, Wei Zhang
Hardware/Software Architecture for Improving the Safety of
Implantable and Wearable Medical Devices (D, A)
Niraj Jha, Younghyun Kim, Anand Raghunathan, Vijay Raghunathan
Hybrid Nanotube/CMOS Dynamically Reconfigurable Architecture
and System Therefor (P)
Niraj Jha, Li Shang, Wei Zhang
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill,
Novimir Pablant
Tracking a Smartphone User Around the World (D)
A Novel Precise Proton Range Diagnostic for Proton Therapy
Treatment (D, A)
Vibration-based Secure Side Channel for Medical Devices (A)
Xiaoliang Dai, Niraj Jha, Prateek Mittal, Arsalan Nia
Niraj Jha, Younghyun Kim, Woo Suk Lee, Vijay Raghunathan
Manfred Bitter, Philip Efthimion, Lan Gao, Kenneth Hill, Dale Meade
20 Celebrate Princeton Invention 2016
invention.princeton.edu
Kaganovich, Igor
Khodak, Andrei
Concept for Reducing Hall Thruster Chamber Wall Erosion With
Lithium Vapor Shielding (A)
A Neutral Beam Pole Shield With Copper Plates and Serviceable
Molybdenum Inserts (D)
Michael Jaworski, Igor Kaganovich, Robert Kaita, Yevgeny Raitses
Andrei Khodak, Peter Titus, Irving Zatz
Neutral Beam Pole Shield (A)
Kahn, Antoine
Andrei Khodak, Peter Titus, Irving Zatz
N-Doping of Organic Semiconductors by Bis-Metallosandwich
Compounds (P)
Kim, Hahn
Stephen Barlow, Song Guo, Antoine Kahn, Seth Marder,
Swagat Mohapatra, Yabing Qi, Kim Sang-Bok
Systems and Methods for Producing Low Work Function
Electrodes (P)
Canek Fuentes-Hernandez, Antoine Kahn, Bernard Kippelen, Seth Marder,
Jens Meyer, Jae Won Shim, Yinhua Zhou
Compounds Having Antibacterial Activity and Methods of Use (A)
Zemer Gitai, Hahn Kim, Maxwell Wilson
Improved SHMT Inhibitors (D, A)
Gregory Ducker, Jonathan Ghergurovich, Hahn Kim, Joshua Rabinowitz
SHMT Inhibitors (A, L)
Gregory Ducker, Jonathan Ghergurovich, Hahn Kim, Joshua Rabinowitz
Kaita, Robert
Concept for Reducing Hall Thruster Chamber Wall Erosion With
Lithium Vapor Shielding (A)
Michael Jaworski, Igor Kaganovich, Robert Kaita, Yevgeny Raitses
Kang, Yibin
Agents, Compositions and Methods for the Treatment of
Metastatic and Chemoresistant Cancers (A)
Mark Esposito, Yibin Kang
ALDH1a3 as a Therapeutic Target in Metastatic and DrugResistant Breast Cancer (D)
Mark Esposito, Yibin Kang
Cell Lines With MTDH KD or KO and Rescue Expression of WT or
MT MTDH or SND1 (D)
Yibin Kang, Minhong Shen, Liling Wan, Yong Wei
Expression Constructs for Various Mutants Forms of MTDH
and SND1 for In Vivo Analysis Through Transient Expression in
Cells (D)
Synthetic Lethal Targeting of Mismatch Repair Defective Cells (A)
Alison Gammie, Hahn Kim, Irene Ojini
Korennykh, Alexei
Identification and Sensitive Detection of Immune Marker RNAs
Generated by the Action of RNase L (D)
Jesse Donovan, Alexei Korennykh
Methods of Monitoring RNase L Activity (A)
Jesse Donovan, Alexei Korennykh
Reporters for Detection of the Human Innate Immune
Messenger (A)
Alisha Chitrakar, Jesse Donovan, Alexei Korennykh
Reporters for Detection of the Human Innate Immune Messenger
2-5A for Research and Diagnostic Purposes (D, A)
Alisha Chitrakar, Jesse Donovan, Alexei Korennykh
Lamb, Kevin
Yibin Kang, Minhong Shen, Liling Wan, Yong Wei
Drone Detection, Video Feed Interception and Pilot Locating
System (A)
Gene Expression Profile Dataset of Cell Lines or Tissues With
Different MTDH or SND1 Status (D)
Kevin Lamb
Yibin Kang, Liling Wan, Yong Wei
In Vitro and In Vivo Assays to Test MTDH and SND1 Function in
Tumor Initiation, Growth and Treatment Resistance (D)
Yibin Kang, Liling Wan, Yong Wei
Jagged 1 as a Marker and Therapeutic Target for Breast Cancer
Bone Metastasis (A)
Yibin Kang, Nilay Sethi
Methods of Identifying and Treating Poor-Prognosis Cancers (A)
Guohong Hu, Yibin Kang
MicroRNAs as Functional Mediators and Biomarkers of Bone
Metastasis (A)
Lee, Ruby
Implicit User Authentication With Smartphone and Smartwatch
Sensors (D, A)
Ruby Lee, Wei-han Lee
Levine, Michael
A Simple Multiplexing ChIP-Seq Assay for Transcription Factors
and Chromatin Landscape (D)
Kai Chen, Michael Levine
Li, Genyuan
MTDH KO, Conditional KO and Transgenic Mice (D)
Data Driven Assessment and Property Prediction of Complex
Multivariate Systems Utilizing High Dimensional Model
Representation (HDMR) (D)
Yibin Kang, Liling Wan
Genyuan Li, Herschel Rabitz, Xi Xing
Brian Ell, Yibin Kang
invention.princeton.edu
Celebrate Princeton Invention 2016 21
“
Meggers, Forrest
Dehumidification of Air by Liquid Desiccant Across Membrane (A)
Forrest Meggers, Jovan Pantelic, Eric Teitelbaum
Spherical-Motion Average Radiant Temperature Sensor (A)
Entrepreneurship the ‘Princeton
way’ is being embraced warmly by
the University community and our
neighboring ecosystems. As Princeton
entrepreneurs keep pushing, pivoting
and persisting, they broaden the
pathways for the University to serve
the nation and humanity.
Mung Chiang
Arthur LeGrand Doty Professor of Electrical
Engineering; Director, Keller Center; Inaugural
Chair, Princeton Entrepreneurship Council
Loo, Yueh-Lin (Lynn)
Merzhevskiy, Alexsandr
Active Protection of Optical Surfaces From Contaminations (D)
Alexandros Gerakis, Alexsandr Merzhevskiy, Yevgeny Raitses,
Vladislav Vekselman
Miles, Richard
Systems and Methods for Lasing From a Molecular Gas (P)
Arthur Dogariu, James Michael, Richard Miles
Mittal, Prateek
”
Single-Junction Organic Solar Cells Utilizing Ultraviolet-Absorbing
Materials and Producing Open-Circuit Voltages Above 1.4 V (A)
Nicholas Davy, Yueh-Lin (Lynn) Loo, Melda Sezen
Forrest Meggers, Jake Read, Eric Teitelbaum
Use of Ultraviolet-Absorbing Materials as the Active Constituents
in an Organic Solar Cell That Produces a Single-Junction OpenCircuit Voltage Above 1.4 V (D)
Nicholas Davy, Yueh-Lin (Lynn) Loo, Melda Sezen
MacMillan, David
Decarboxylative Conjugate Additions and Applications Thereof (A)
David MacMillan, Stefan McCarver, Daniel Novoa
Majeski, Richard
A Method to Distill Hydrogen Isotopes From Lithium (D, A)
Richard Majeski
Root ORAM: Practical and Secure Random Access Memory (D, A)
Paul Cuff, Prateek Mittal, Sameer Wagh
Tracking a Smartphone User Around the World (D)
Xiaoliang Dai, Niraj Jha, Prateek Mittal, Arsalan Nia
Muir, Tom
Design of a Split Intein With Exceptional Protein Splicing
Activity (D, A)
Tom Muir, Neel Shah, Adam Stevens
Nucleosome Assays to Identify Inhibitors of Histone Lysine
Demethylases (D)
David Bennett, Zachary Brown, Christian Fischer, Tom Muir, Manuel Muller,
Benjamin Nicholson, Stuart Shumway, Brooke Swalm
Phosphohistidine Mimetics and Antibodies to Same (A)
Jung-Min Kee, Tom Muir, Rob Oslund
Surfaces Comprising Attached Quorum Sensing Modulators (A)
Bonnie Bassler, Minyoung Kim, Tom Muir, Howard Stone, Aishan Zhao
Murphy, Coleen
Biomarkers of Oocyte Quality (A)
Coleen Murphy
McAlpine, Michael
Ong, Nai-Phuan
3-D Printed Active Electronic Materials and Devices (A)
Electronic Interconnects and Devices With Topological Surface
States and Methods for Fabricating Same (A)
Yong Lin Kong, Michael McAlpine
3-D Printed Patient-Specific Conduits for Complex Peripheral
Nerve Injury (A)
Blake Johnson, Michael McAlpine
Meade, Dale
A Novel Precise Proton Range Diagnostic for Proton Therapy
Treatment (D, A)
Manfred Bitter, Lan Gao, Philip Efthimion, Kenneth Hill, Dale Meade
22 Celebrate Princeton Invention 2016
Robert Cava, Nai-Phuan Ong, Ali Yazdani
Electronic Interconnects and Devices With Topological Surface
States and Methods for Fabricating Same (P)
Robert Cava, Nai-Phuan Ong, Ali Yazdani
Pablant, Novimir
A Multi-Cone X-ray Imaging Bragg Crystal Spectrometer (D, A)
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Lan Gao,
Kenneth Hill, Novimir Pablant
invention.princeton.edu
A New Class of Focusing Crystal Surfaces for the Bragg
Spectroscopy of High-Density Plasmas and Small (Point-Like)
X-ray Sources (A)
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill,
Novimir Pablant
The Proper Geometry for Conical X-ray Crystal Spectrographs and
Novel Experimental Arrangements for the Spectroscopy of LaserProduced Plasmas and Other Small (Point-Like) X-ray Sources (D)
Manfred Bitter, Luis Delgado-Aparicio, Philip Efthimion, Kenneth Hill,
Novimir Pablant
Pai, Vivek
Virtual Address Pager and Method for Use With a Bulk Erase
Memory (P)
Anirudh Badam, Vivek Pai
Pelczer, Istvan
Nutritional Supplement/Feed Formula and Methods of Use
Thereof to Inhibit Development of Osteochondrosis Dissecans
(OCD) Lesions (A, L)
Istvan Pelczer, Sarah Ralston
A Silicon Photonic Integrated Circuit for Radio-Frequency SelfInterference Cancellation (D, A, L)
Matthew Chang, Paul Prucnal, Alexander Tait
Multibeam Radio Frequency Photonic Beamformer Using a MultiSignal Slow Light Time Delay Unit (A)
John Chang, Matthew Chang, Paul Prucnal
Optical Counter Phase Modulation Method of RF Interference
Cancellation (L)
Konstantin Kravtsov, Paul Prucnal, John Suarez
System and Method for Photonic Processing (A)
Mitchell Nahmias, Paul Prucnal, Bhavin Shastri, Alexander Tait
Prud’homme, Robert
Co-Encapsulation of Antimicrobials and Antimicrobial Adjuvants
in Nanocarriers (A)
Hoang Lu, Robert Prud’homme
Nano-Encapsulation Using GRAS Materials and Applications
Thereof (A)
Robert Prud’homme, Nikolas Weissmueller
Nanoparticle Vaccine Compositions and Applications Thereof (A)
Petta, Jason
Robert Prud’homme, Ruth Rosenthal, Nikolas Weissmueller
Overlapping Gate Architecture for Linear Arrays of Si/SiGe
Quantum Dots (D)
Printed Electronics (P)
Thomas Hazard, Jason Petta, David Zajac
Ilhan Aksay, Chuan-Hua Chen, Katherine Chiang, John Crain, Sibel Korkut
Punckt, John Lettow, Robert Prud’homme
Semiconductor Quantum Dot Device and Method for Forming a
Scalable Linear Array of Quantum Dots (A)
Process for Encapsulating Soluble Biologics, Therapeutics and
Imaging Agents (D, A)
Thomas Hazard, Jason Petta, David Zajac
Chester Markwalter, Robert Pagels, Robert Prud’homme
Ploss, Alexander
Rabinowitz, Joshua
A Method for Identifying Host-Targeting Anti-Hepatitis B Virus
Compounds (D)
Compositions and Methods for Enhancing Immunotherapy (A)
Alexander Ploss, Benjamin Winer
Generation of a Cell Line Susceptible to Hepatitis B and Delta
Viruses (A)
Alexander Ploss, Benjamin Winer
Poor, H. Vincent
Disintegrated Channel Estimation in Filter-and-Forward Relay
Networks (D, A)
Kao-Peng Chou, Jia-Chin Lin, H. Vincent Poor
Initial Synchronization Exploiting Inherent Diversity for the LTE
Sector Search Process (D, A)
Jia-Chin Lin, H. Vincent Poor, Yu-Ting Sun
System and Method for Initial Ranging in Wireless
Communication Systems (P)
Michele Morelli, H. Vincent Poor, Luca Sanguinetti
System and Method for Lossy Source-Channel Coding at the
Application Layer (P)
Giuseppe Caire, Maria Fresia, H. Vincent Poor, Ozgun Bursalioglu Yilmaz
Joshua Rabinowitz
Dietary Supplements and Compositions for Treating Cancer (A, L)
Jing Fan, Jurre Kamphorst, Joshua Rabinowitz, Craig Thompson,
Jianbin Ye
Electronic Inhaler for Delivery of Pharmaceuticals via Heating
and Vaporization (D)
Joshua Rabinowitz
Enhancement of Immunotherapy via Genetic Manipulation of the
Tumor Metabolic Environment (D)
Joshua Rabinowitz
Folate-Dependent NADPH Production (L)
Gregory Ducker, Jing Fan, Joshua Rabinowitz
Improved SHMT Inhibitors (D, A)
Gregory Ducker, Jonathan Ghergurovich, Hahn Kim, Joshua Rabinowitz
Inhibition of Glycerol-3-Phosphate Acyltransferase (GPAT) and
Associated Enzymes for Treatment of Viral Infections (A)
Sean Liu, Joshua Rabinowitz, Thomas Shenk
Inhibition of Glycerol-3-Phosphate Acyltransferase (GPAT) and
Associated Enzymes for Treatment of Viral Infections (P)
Prucnal, Paul
Sean Liu, Joshua Rabinowitz, Thomas Shenk
A III-V Photonic Integrated Circuit for Radio-Frequency SelfInterference Cancellation (D, A, L)
Inhibitors of Long and Very Long Chain Fatty Acid Metabolism
as Broad Spectrum Anti-Virals (A)
Matthew Chang, Paul Prucnal
Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk
invention.princeton.edu
Celebrate Princeton Invention 2016 23
Inhibitors of Long and Very Long Chain Fatty Acid Metabolism
as Broad Spectrum Anti-Virals (P)
Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk
Thin-Film Devices With Light Extraction Layers (A)
Tae-Wook Koh, Barry Rand
Lipid Scavenging in RAS Cancers (A)
Use of an Organic Underlayer to Enable Crystallization of
Disordered Organic Thin Films (D, A)
Justin Cross, Jurre Kamphorst, Joshua Rabinowitz, Craig Thompson
Michael Fusella, Barry Rand, Siyu Yang
Method to Produce Virus in Cultured Cells (A)
Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk
Rodriguez, Alejandro
Methods and Devices for Controlled Drug Vaporization (A)
Overlap Optimization of Nonlinear Frequency Conversion in MultiMode Cavities (A)
Joshua Rabinowitz
Methods and Materials for Producing Polyols and Electron Rich
Compounds (A)
Sarah Johnson, Fabien Letisse, Joshua Rabinowitz, Yi-Fan Xu
Steven Johnson, Zin Lin, Marko Loncar, Alejandro Rodriguez
Romalis, Michael
Methods to Enhance the Yield of Infectious Human
Cytomegalovirus and Varicella Zoster Virus in Cultured Cells (P)
A Device Using Polarized K Atoms to Measure Magnetic Fields
With Higher Sensitivity Than Best Existing Devices of This
Type (L)
Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk
Joel Allred, Ioannis Kominis, Tom Kornack, Rob Lyman, Michael Romalis
NADPH Production by the 10-Formyl-THF Pathway, and Its Use
in the Diagnosis and Treatment of Disease (D, A)
Atomic Magnetometer for RF Detection (L)
Gregory Ducker, Jing Fan, Ling Liu, Joshua Rabinowitz
SHMT Inhibitors (A, L)
Michael Romalis, Karen Sauer, Igor Savukov, Scott Seltzer
Pulsed Scalar Atomic Magnetometer (D, A, L)
Andrei Baranga, Haifeng Dong, Michael Romalis
Gregory Ducker, Jonathan Ghergurovich, Hahn Kim, Joshua Rabinowitz
Treatment of Viral Infections by Modulation of Host Cell
Metabolic Pathways (A)
Bryson Bennett, Joshua Munger, Joshua Rabinowitz, Thomas Shenk
Rabitz, Herschel
Data Driven Assessment and Property Prediction of Complex
Multivariate Systems Utilizing High Dimensional Model
Representation (HDMR) (D)
Genyuan Li, Herschel Rabitz, Xi Xing
Hybrid, High Power Laser System (D, A)
Alexei Goun, Herschel Rabitz
Optimal Control in the Sciences Over Vast Length and Time
Scales (OptiSci) (D)
Herschel Rabitz
Raitses, Yevgeny
Active Protection of Optical Surfaces From Contaminations (D)
Alexandros Gerakis, Alexsandr Merzhevskiy, Yevgeny Raitses,
Vladislav Vekselman
Concept for Reducing Hall Thruster Chamber Wall Erosion With
Lithium Vapor Shielding (A)
Michael Jaworski, Igor Kaganovich, Robert Kaita, Yevgeny Raitses
Rand, Barry
A Solid-State Organic Intermediate Band Solar Cell Based on
Principles of Triplet-Triplet Annihilation (D, A)
YunHui Lin, Barry Rand
High Efficiency Organic Photovoltaic Cells Employing Hybridized
Mixed-Planar Heterojunctions (P)
Stephen Forrest, Barry Rand, Soichi Uchida, Jiangeng Xue
Method of Forming and Applications of Metal Halide Perovskite
Films With Small Crystallite Size (D, A)
Ross Kerner, Barry Rand, Zhengguo Xiao
24 Celebrate Princeton Invention 2016
Scherer, George
Aluminum Phosphate Consolidant for Stone (D, A)
Enrico Sassoni, George Scherer
Schneider, Hans
Automated Testing Instrument for Verification of Complex
Computational Systems (D, A)
John Dong, Hans Schneider, Gretchen Zimmer
Distributed Intelligence Architecture for Real-Time Control,
Protection and Instrumentation Systems (D, A)
Hans Schneider, Greg Tchilinguirian
Schwartz, Jeffrey
A Three-Dimensional (3-D) Tissue Scaffold With Cell
Alignment (D)
Craig Arnold, Stephen Bandini, Jeffrey Schwartz, Joshua Spechler
Nanoparticle Surface Modification (P)
Jeffrey Schwartz, Christopher Traina
Patterning a Shape Memory Polymer Scaffold for Spatial Control
of Cell Growth on Non-Planar Surfaces (D)
Lily Adler, Stephen Bandini, Gregory Harris, Alomi Parikh, Jeffrey Schwartz,
Jean Schwarzbauer
Patterning of Fragile or Non-Planar Surfaces for Cell Alignment (A)
Lily Adler, Stephen Bandini, Gregory Harris, Alomi Parikh, Jeffrey Schwartz,
Jean Schwarzbauer, Joshua Spechler
Scaffolds for Tissues and Uses Thereof (A)
Jeffrey Schwartz, Jean Schwarzbauer
Schwarzbauer, Jean
Patterning a Shape Memory Polymer Scaffold for Spatial Control
of Cell Growth on Non-Planar Surfaces (D)
Lily Adler, Stephen Bandini, Gregory Harris, Alomi Parikh, Jeffrey Schwartz,
Jean Schwarzbauer
invention.princeton.edu
Patterning of Fragile or Non-Planar Surfaces for Cell Alignment (A)
Lily Adler, Stephen Bandini, Gregory Harris, Alomi Parikh, Jeffrey Schwartz,
Jean Schwarzbauer, Joshua Spechler
Scaffolds for Tissues and Uses Thereof (A)
Silber, Kenneth
Plasma Incinerator System for the Reduction and Processing
of Bulk Materials (D)
Philip Efthimion, Charles Gentile, Kenneth Silber
Jeffrey Schwartz, Jean Schwarzbauer
Silverman, Sanford
Semmelhack, Martin
Heterocycle Analogs of CAI-1 as Agonists of Quorum Sensing
in Vibrio (A)
Systems for Induction of Gene Expression and Protein Depletion
in Yeast (P)
David Botstein, Robert McIsaac, Marcus Noyes, Sanford Silverman
Bonnie Bassler, Lark Perez, Martin Semmelhack
Molecules and Compositions That Inhibit Gram Negative Bacteria
and Their Uses (A)
Bonnie Bassler, Knut Drescher, Laura Miller Conrad, Colleen O’Loughlin,
Martin Semmelhack, Albert Siryaporn
Sengupta, Kaushik
Frequency-Reconfigurable Integrated Power Amplifier and
Transmitter Architectures (D, A)
Smits, Alexander
Liquid-Infused Surfaces Featuring Reduced Drag Characteristics,
and Methods for Fabricating the Same (A)
Matthew Fu, Marcus Hultmark, Ian Jacobi, Brian Rosenberg,
Alexander Smits, Howard Stone, Jason Wexler
Soboyejo, Winston
Reversible-Magnetic, Self-Erasing Chalkboard (D, A)
Chandrakanth Chappidi, Kaushik Sengupta
Aarav Chavda, Isaac Ilivicky, Winston Soboyejo
Shenk, Thomas
Sorensen, Erik
CMV-GFP Reporter (D, L)
Acceptorless Catalytic Dehydrogenation (A)
Thomas Shenk, Dai Wang
Erik Sorensen, Julian West
Inhibition of Glycerol-3-Phosphate Acyltransferase (GPAT) and
Associated Enzymes for Treatment of Viral Infections (A)
C-H Bond Fluorination With Visible Light Uranyl
Photocatalysts (A)
Sean Liu, Joshua Rabinowitz, Thomas Shenk
Erik Sorensen, Julian West
Inhibition of Glycerol-3-Phosphate Acyltransferase (GPAT) and
Associated Enzymes for Treatment of Viral Infections (P)
Steingart, Daniel
Sean Liu, Joshua Rabinowitz, Thomas Shenk
Inhibitors of Long and Very Long Chain Fatty Acid Metabolism
as Broad Spectrum Anti-Virals (A)
Alkaline Battery Electrolyte Useful for a Rechargeable Alkaline
Electrochemical Cell (A)
Mylad Chamoun, Greg Davies, Benjamin Hertzberg, Ying Meng,
Daniel Steingart
Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk
Inhibitors of Long and Very Long Chain Fatty Acid Metabolism
as Broad Spectrum Anti-Virals (P)
Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk
Method to Produce Virus in Cultured Cells (A)
Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk
Methods to Enhance the Yield of Infectious Human
Cytomegalovirus and Varicella Zoster Virus in Cultured Cells (P)
Emre Koyuncu, Joshua Rabinowitz, Thomas Shenk
Modulators of Sirtuins as Inhibitors of Human
Cytomegalovirus (A)
Ileana Cristea, Emre Koyuncu, Thomas Shenk
Sirt4 Lipoamidase Activity and Uses Thereof (A)
Ileana Cristea, Todd Greco, Rommel Mathias, Adam Oberstein,
Thomas Shenk
Treatment of Viral Infections by Modulation of Host Cell
Metabolic Pathways (A)
Bryson Bennett, Joshua Munger, Joshua Rabinowitz, Thomas Shenk
invention.princeton.edu
Hyper-Dendritic Nanoporous Zinc Foam Anodes, Methods of
Producing the Same, and Methods for Their Use (A)
Mylad Chamoun, Greg Davies, Benjamin Hertzberg, Andrew Hsieh,
Daniel Steingart
Membrane-Free Non-Flowing Single Cell Zinc Bromine Battery
With Bromine-Trapping Composite Carbon Foam Electrode (D, A)
Shaurjo Biswas, Thomas Hodson, Robert Mohr, Aoi Senju,
Daniel Steingart
Steinhardt, Paul
Hyperuniform and Nearly Hyperuniform Random Network
Materials (A)
Miroslav Hejna, Paul Steinhardt, Salvatore Torquato
Non-Crystalline Materials Having Complete Photonic, Electric
or Phononic Band Gaps (A)
Marian Florescu, Paul Steinhardt, Salvatore Torquato
Non-Crystalline Materials Having Complete Photonic, Electronic,
or Phononic Bandgaps (P)
Marian Florescu, Paul Steinhardt, Salvatore Torquato
Celebrate Princeton Invention 2016 25
Stone, Howard
A Localized Coating Method With a Binary Mixture and Polymer
Additive (A)
Francois Boulogne, Hyoungsoo Kim, Howard Stone
Control of the Drying Stress in Colloidal Suspensions by Choosing
a Distribution of Particle Sizes (D)
Francois Boulogne, Yong Lin Kong, Janine Nunes, Howard Stone
Gating of a Mechanosensitive Channel by Fluid Flows (D, A)
Gary Marple, On Shun Pak, Howard Stone, Shravan Veerapaneni,
Yuan Nan Young
Inhibiting the Colonization, Growth and Dispersal of Pathogenic
Bacteria in Healthcare Devices and Patients Through Surface
Chemistry Treatments and Fluid Flow Control (A)
Zemer Gitai, Minyoung Kim, Yi Shen, Albert Siryaporn, Howard Stone
Injectable Hydrogels From Microfiber Suspensions (A)
Stefano Guido, Janine Nunes, Antonio Perazzo, Howard Stone
Liquid-Infused Surfaces Featuring Reduced Drag Characteristics,
and Methods for Fabricating the Same (A)
On-Chip Microfluidic Processing of Particles (A)
Robert Austin, Yu Chen, Curt Civin, Joseph D’Silva, Michael Grisham,
James Sturm
Post Geometry Designs for High Throughput Separation
of Nucleated Cells From Blood With Deterministic Lateral
Displacement Arrays (D)
Robert Austin, Joseph D’Silva, James Sturm
Post Geometry Designs for High Throughput Separation
of Nucleated Cells From Blood With Deterministic Lateral
Displacement Arrays (D, A)
Robert Austin, Joseph D’Silva, James Sturm
System and Method for 3-D Position and Gesture Sensing of
Human Hand (A)
Yingzhe Hu, Liechao Huang, James Sturm, Naveen Verma, Sigurd Wagner
System and Method for 3-D Position and Gesture Sensing of
Human Hand (A)
Yingzhe Hu, Liechao Huang, Warren Rieutort-Louis, Josue Sanz-Robinson,
James Sturm, Naveen Verma, Sigurd Wagner
Matthew Fu, Marcus Hultmark, Ian Jacobi, Brian Rosenberg,
Alexander Smits, Howard Stone, Jason Wexler
Suckewer, Szymon
Method for Uniform Deposition of Particles on Absorbing
Hydrogels (A)
Szymon Suckewer
Francois Boulogne, Francois Bernard Ingremeau, Laurent Limat,
Howard Stone
Particle Motion in Suspensions Driven by Contact With Gas (D, A)
Orest Shardt, Suin Shim, Sangwoo Shin, Howard Stone, Patrick Warren
Reduction of the Drying Stress in Colloidal Suspensions by
Choosing a Distribution of Particle Sizes (A)
Francois Boulogne, Yong Lin Kong, Janine Nunes, Howard Stone
Surfaces Comprising Attached Quorum Sensing Modulators (A)
Bonnie Bassler, Minyoung Kim, Tom Muir, Howard Stone, Aishan Zhao
System and Method for Emulsion Breaking and Phase Separation
by Droplet Adhesion (A)
Compact Plasma Laser for Dermatology Applications (D)
Intrastromal Corneal Reshaping Method and Apparatus for
Correction of Refractive Errors Using Ultra-Short and UltraIntensive Laser Pulses (A)
Taehee Han, Peter Hersh, Szymon Suckewer
Tattoo Removal With Two Laser Beams via Multi-Photon
Processes (P)
Szymon Suckewer
Tchilinguirian, Greg
Distributed Intelligence Architecture for Real-Time Control,
Protection and Instrumentation Systems (D, A)
Hans Schneider, Greg Tchilinguirian
Haosheng Chen, Jiang Li, Howard Stone
Tian, Haoshu
Sturm, James
High Efficiency Microfluidic Purification of Stem Cells to Improve
Transplants (A)
Do People Answer Online Questionnaires Carelessly? Assessing
the Quality of Online Questionnaires Through Data Mining (D)
Qikun Niu, Haoshu Tian, Yiqiao (Joe) Zhong
Robert Austin, Curt Civin, James Sturm
Methods and Devices for High Throughput Purification (A)
Titus, Peter
Robert Austin, Yu Chen, Curt Civin, Joseph D’Silva, James Sturm
A Neutral Beam Pole Shield With Copper Plates and Serviceable
Molybdenum Inserts (D)
Methods and Devices for Multi-Step Cell Purification (D, A)
Lee Aurich, Curt Civin, Khushroo Gandhi, Michael Grisham, Alison Skelley,
James Sturm, Anthony Ward
Andrei Khodak, Peter Titus, Irving Zatz
Neutral Beam Pole Shield (A)
Methods and Devices for Multi-Step Cell Purification and
Concentration (A)
Andrei Khodak, Peter Titus, Irving Zatz
Lee Aurich, Curt Civin, Khushroo Gandhi, Michael Grisham, Alison Skelley,
James Sturm, Anthony Ward
Tobias, Benjamin
Methods and Systems for Processing Particles (A)
Self-Aligning Mirror Mechanism for Transmission Line Offset
Correction (D, A)
Robert Austin, Yu Chen, Curt Civin, Joseph D’Silva, Michael Grisham,
James Sturm
Cara Bagley, Michael Gomez, Benjamin Tobias, Ali Zolfaghari
Microfluidic System for Cell Processing Using Deterministic
Lateral Displacement Arrays for Cell Separation and Washing,
and an Incubator for Cell Incubation (D)
Toettcher, Jared
Robert Austin, Yu Chen, James Sturm
Alexander Goglia, Jared Toettcher, Maxwell Wilson
26 Celebrate Princeton Invention 2016
Cancer Cell Therapy (D)
invention.princeton.edu
Light Activated Gene Transcription of Metabolic Enzymes
for Metabolic Pathway Tuning and Induction of Promoter
Cascades (D)
José Avalos, Jared Toettcher, Evan Zhao
Optical Control of Transcription of Metabolic Enzymes for Tuning
of Engineered Metabolic Pathways and Induction of Promoter
Cascades (A)
José Avalos, Jared Toettcher, Evan Zhao
Optogenetic Cell Therapy (D)
Alexander Goglia, Jared Toettcher, Maxwell Wilson
Optogenetic Tool for Rapid and Reversible Clustering of
Proteins (D, A)
Clifford Brangwynne, Yongdae Shin, Jared Toettcher
Torquato, Salvatore
Density Enhancement Methods and Compositions (A)
Adam Hopkins, Salvatore Torquato
Hyperuniform and Nearly Hyperuniform Random Network
Materials (A)
A Strong Machine-Learning Classifier Integrated Directly Within
a Standard 6T SRAM Array (D, A)
Naveen Verma, Zhuo Wang, Jintao Zhang
Multiplying Analog to Digital Converter and Method (A)
Naveen Verma, Zhuo Wang, Jintao Zhang
System and Method for 3-D Position and Gesture Sensing of
Human Hand (A)
Yingzhe Hu, Liechao Huang, James Sturm, Naveen Verma, Sigurd Wagner
System and Method for 3-D Position and Gesture Sensing of
Human Hand (A)
Yingzhe Hu, Liechao Huang, Warren Rieutort-Louis, Josue Sanz-Robinson,
James Sturm, Naveen Verma, Sigurd Wagner
Viola, Michael
Adjustable Portable Tensile Testing Machine (A)
Michael Viola
Wagner, Sigurd
Miroslav Hejna, Paul Steinhardt, Salvatore Torquato
Hybrid Layers for Use in Coatings on Electronic Devices or Other
Articles (P)
Non-Crystalline Materials Having Complete Photonic, Electric
or Phononic Band Gaps (A)
Julia Brown, Lin Han, Ruiqing Ma, Prashant Mandlik, Jeffrey Silvernail,
Sigurd Wagner
Marian Florescu, Paul Steinhardt, Salvatore Torquato
Non-Crystalline Materials Having Complete Photonic, Electronic,
or Phononic Bandgaps (P)
Marian Florescu, Paul Steinhardt, Salvatore Torquato
Tromp, Jeroen
Medical Imaging Based on Full Waveform Inversion or Adjoint
Tomography (D)
System and Method for 3-D Position and Gesture Sensing of
Human Hand (A)
Yingzhe Hu, Liechao Huang, James Sturm, Naveen Verma, Sigurd Wagner
System and Method for 3-D Position and Gesture Sensing of
Human Hand (A)
Yingzhe Hu, Liechao Huang, Warren Rieutort-Louis, Josue Sanz-Robinson,
James Sturm, Naveen Verma, Sigurd Wagner
Etienne Bachmann, Jeroen Tromp
White, Claire
Troyanskaya, Olga
Nanoparticles to Mitigate Microcracking in Alkali-Activated
Materials (A)
Method of Use of Targeting Specific Antigen Combinations Using
Engineered Multi-Receptor Immune Cells for Cancer Therapy (D)
Claire White
Wendell Lim, Olga Troyanskaya, Benjamin VanderSluis
Woolley, Robert
Systems and Methods for Targeting Cancer Cells (A)
Dual Tokamak With Alternating Current Inductive Plasma
Formation and Sustainment (D)
Wendell Lim, Olga Troyanskaya, Benjamin VanderSluis
Tully, Christopher
Transition-Edge Sensor X-ray Fluorescence (TES-XRF) for High
Resolution Material Identification (D, A)
Charles Gentile, Christopher Tully
Robert Woolley
Wysocki, Gerard
Cavity-Enhanced Heterodyne Faraday Rotation Spectroscopy
Using a Conventional Two-Mirror or Novel Three-Mirror Cavity
Design (A)
Brian Brumfield, Gerard Wysocki
Vekselman, Vladislav
Active Protection of Optical Surfaces From Contaminations (D)
Alexandros Gerakis, Alexsandr Merzhevskiy, Yevgeny Raitses, Vladislav
Vekselman
Chemical Detection Based on Laser Spectroscopic Sensing of
Anomalous Molecular/Atomic Dispersion (L)
Damien Weidmann, Gerard Wysocki
Chirped Laser Dispersion Spectroscopy Sensitivity Booster (D, A)
Verma, Naveen
A Machine-Learning Classifier Based on Comparators for Direct
Inference on Analog Sensor Data (D, A)
Naveen Verma, Zhuo Wang
invention.princeton.edu
Yifeng Chen, Genevieve Plant, Gerard Wysocki
Frequency Stabilized Cavity Ring Down Faraday Rotation
Spectroscopy (A)
Helen Waechter, Jonas Westberg, Gerard Wysocki
Celebrate Princeton Invention 2016 27
Frequency Stabilized Cavity Ring Down Faraday Rotation
Spectroscopy — Experimental Procedures and Data Analysis
Methods (D)
Helen Waechter, Jonas Westberg, Gerard Wysocki
Simultaneous Ranging and Remote Chemical Sensing Utilizing
Optical Dispersion or Absorption Spectroscopy (A)
Andreas Hangauer, Gerard Wysocki
Yao, Nan
Patterned Charge Generation Using Torsional Mode Atomic Force
Microscopy (D, A)
Wei Cai, Nan Yao
Scanning Probe Lithography Using Non-Raster Trajectories (D, A)
Wei Cai, Nan Yao
Yazdani, Ali
Electronic Interconnects and Devices With Topological Surface
States and Methods for Fabricating Same (A)
Robert Cava, Nai-Phuan Ong, Ali Yazdani
Electronic Interconnects and Devices With Topological Surface
States and Methods for Fabricating Same (P)
Robert Cava, Nai-Phuan Ong, Ali Yazdani
Magnetic Topological Nanowires (A)
B. Andrei Bernevig, Ali Yazdani
Zatz, Irving
A Neutral Beam Pole Shield With Copper Plates and Serviceable
Molybdenum Inserts (D)
Andrei Khodak, Peter Titus, Irving Zatz
Neutral Beam Pole Shield (A)
Andrei Khodak, Peter Titus, Irving Zatz
Zhong, Yiqiao (Joe)
Do People Answer Online Questionnaires Carelessly? Assessing
the Quality of Online Questionnaires Through Data Mining (D)
Qikun Niu, Haoshu Tian, Yiqiao (Joe) Zhong
Zimmer, Gretchen
Automated Testing Instrument for Verification of Complex
Computational Systems (D, A)
John Dong, Hans Schneider, Gretchen Zimmer
Zolfaghari, Ali
Self-Aligning Mirror Mechanism for Transmission Line Offset
Correction (D, A)
Cara Bagley, Michael Gomez, Benjamin Tobias, Ali Zolfaghar
Key: D = Disclosure A = Application P = Patent L = License
Faculty member or lead inventor
Invention Title + Invention Status (D, A, P, L)
All inventors, alphabetical by last name
28 Celebrate Princeton Invention 2016
invention.princeton.edu
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Published by the Office of the Dean for Research
Text by Catherine Zandonella and John Greenwald
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Photography by Denise Applewhite, Sameer A. Khan, Christopher Lillja, C. Todd Reichart,
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Cover illustration by Stephanie Dalton Cowan
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invention.princeton.edu