Apothagram F eatured P roduct ® PCCA T3 Sodium Dilution™ (1:1000) A MONTHLY PUBLICATION FROM PROFESSIONAL COMPOUNDING CENTERS OF AMERICA PCCA #55-4250 JULY 2011 Congratulations to David Miller, RPh, PhD, of Keystone Pharmacy in Grand Rapids, Mich., PCCA’s July Pharmacist of the Month. David Miller, RPh, PhD S tats : • BS from Ferris State University in 1990; MS in Pharmaceutics from University of Michigan in 1994; PhD in Pharmaceutics from University of Michigan in 1996, with an emphasis in transdermal drug delivery, specializing in iontophoresis Compounding is a perfect fit for someone with a formulation development background. When I first heard of the opportunity to join Keystone Pharmacy as a compounding specialist, I was excited to have a chance to work on smaller formulation development, focusing on one patient at a time. My partner and mentor, Larry Curtis, RPh, encouraged me to come to Michigan for a visit. Afterwards, I was so excited about the opportunity that compounding presented that I could not wait to move from Salt Lake City back to Grand Rapids to begin my new career! At Keystone Pharmacy, I face thrilling challenges that my team and I are forced to tackle daily. Because of my basis in pharmaceutics, I have the physiochemical background that is necessary to overcome most formulation difficulties, and the insight into how to solve drug delivery challenges. Favorite PCCA Formulas I love pain management. I love the gratification that comes from helping a patient alleviate their pain. My favorite formulas are Ketamine 10%, Gabapentin 6%, Clonidine 0.2%, Lidocaine HCl 2% Topical Lipoderm® (PCCA Formula #9383), and variations thereof. Typically at Keystone Pharmacy, we’ll add Amitriptyline 7% and Ketoprofen 10% to the formulation. It is my goal with pain management to help end the patient’s pain as expediently • Nine years of compounding experience as possible. Typically, these patients are very difficult to treat. Their physicians have tried all of the easy things with them; therefore, they frequently are in despair and • Pharmacy prepares 113 compounds feel hopeless. By using the “shotgun approach,” and hitting as many of the seven pain per day modulators as possible (sodium channel; opioid; GABA; glutamate and aspartate, including AMPA and NMDA; epi/norepinephrine; and inflammatory, including prostaglandin-mediated and alpha agonist), it is my opinion that we have the best chance of mitigating the patient’s pain and giving them back their quality of life. Compounding Success Stories At Keystone Pharmacy, we’ve been on the receiving end of many stories with positive outcomes, which continually add to the reasons of why I compound. Our first story is about Steve, a motorcycle crash victim who had severe neuropathic pain in his legs as a result of his injuries. He hadn’t slept in months because of the pain, and he often felt desperate and hopeless. The pain clinic was at their wits’ end with Steve, but I convinced the doctor to allow me to try a pain Table of Contents cream using the “shotgun approach” mentioned above. Steve was skeptical, but picked up Page his cream the next morning and applied it three times that day. The following morning, Article I called Steve to follow up. He reported that he was nearly pain-free, and slept for eight Technician of the Month 2 hours the previous night! He literally was in tears, overcome by the relief and hope that Consultant's Corner 3 these compounded formulations afforded. PK Soft ware Our second story features Violet, an 89-year-old terminal cancer patient. Violet had 4 collapsed veins, muscle wasting, could not take anything by mouth, had a rectal fistula, Dates to Remember/ 5 and her integument (skin) was degrading. The doctors couldn’t think of a practical Ask Artie way to administer morphine, or any other opioid, to relieve her pain. I suggested using Formula Spotlight/ a Morphine 10 mg/3 mL Solution (modified PCCA Formula #3253) in a nebulizer, 6 Product of the Month allowing Violet to inhale her pain relief. Her physician later reported that Violet received August Events 7 adequate pain relief as a result of the nebulized formulation, and that she passed away pain-free. In the News 8 PCCA PHARMACIST OF THE MONTH D AV I D M I L L E R , R P h , P h D Congratulations to Bea F. Mendoza, CPhT, of Thrifty Health & Compounding Pharmacy in Humble, Texas, PCCA’s July Technician of the Month. The pharmacy is owned by Terry Mielke, RPh. PCCA TECHNICIAN OF THE MONTH B E A F. M E N D O Z A , C P h T Training and Education I started my pharmacy career while I was still in the Army, obtaining training as a pharmacy technician. After four years, I was hired on at Texas Children’s Hospital Pharmacy in the compounding department. Within this department, I primarily learned how to do hospital compounding. Fortunately, because of my compounding experience and my eye for detail, I was able to land a position as an Investigational Drugs Service Pharmacy Technician. As an Investigational Drugs Service Pharmacy Technician, I had the privilege to do a portion of my work with NASA. I was given the opportunity to prepare sterile, stable isotopes for several NASA space flight studies that were being conducted on the astronauts and cosmonauts. Of these, the most memorable was STS-90, which launched John Glenn back into space. After working at Texas Children’s Hospital for 11 years, I decided it was time for a new experience. I began working at Thrifty Health & Compounding Pharmacy, and have now been here for nine and a half years. Because of Thrifty Health & Compounding Pharmacy, I’ve learned to love patient interactions and questions. I also love the curiosity from our doctors, patients, and other pharmacists. Prior to this job, these were things that I didn’t have the opportunity to experience as much. I’m very glad that at Thrifty Health & Compounding Pharmacy I get to have these positive experiences, and I wish I could be even more involved with my patients. Compounding Success Story One of the things I love about my job is the close relationships that we are able to have with our patients. They rely on us to take care of their needs. One example of someone we were able to help was Ms. Bettie. We helped her through the use of PCCA Formula #9448, Ketoprofen 10% Topical Lipoderm® (PCCA FormulaPlus™ BUD Study). Ms. Bettie originally had arthritis in her hands, but thanks to the ketoprofen in the Lipoderm cream, she saw improvements and relief. She is so grateful to us because she now can do everyday things with ease again. Bea F. Mendoza, CPhT S tats : • • • • • Received her training in the Army At Thrifty Health & Compounding Pharmacy for nine and a half years. Received her non-sterile compounding training from PCCA in October 2001. Attended PCCA’s Aseptic Compounding Technique Course in November 2002. “My favorite piece of lab equipment is the Jaansun® Capsule Machine Vibrator. It cuts my capsule prep time in half while helping to accurately fill capsules. The dishwasher is a close second!” Favorite Formulas My favorite formulas are the hormones for our menopausal patients. The patients, as well as their families, are always so thrilled and grateful to have a product that can make their lives more comfortable. I also find satisfaction when helping pets, especially dogs with epilepsy. When you have seen a pet have a seizure, and you know that potassium bromide can prevent it, such as PCCA Formula #4523, Potassium Bromide 350 mg/mL Oral Solution (Vet), preparing their prescriptions is very rewarding. The same satisfaction goes for the pediatric prescriptions we compound. There is nothing better than knowing that you are helping a child in need! “This Works for Me” By: David Miller, RPh, PhD Advice for a new compounder: 1. Obtain a mentor and listen to their advice. A mentor can help to guide you down the right path to ensure your patients receive the best care. 2. Surround yourself with a dedicated and talented team who has a passion for helping people. 3. Always put the needs of your patients first. By putting the needs of your patients first, and working to solve their problems to the best of your ability, your business will f lourish, and you will be happier as you reap the love and respect that comes with those efforts. 4. Build your practice on safety. 5. Never stop learning! 2
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