Predictive factors of invasive cancer in patients with biopsyproven ductal carcinoma in situ: an indicator to sentinel
lymph node biopsy in management of ductal carcinoma in
situ
Poster No.:
C-0925
Congress:
ECR 2011
Type:
Scientific Paper
Authors:
K. E. Lee, H. H. Kim, H. J. Shin, J. H. Cha, O. H. Woo; Seoul/KR
Keywords:
Breast, Mammography, Ultrasound, MR, Treatment effects,
Diagnostic procedure, Metastases
DOI:
10.1594/ecr2011/C-0925
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Purpose
The purspose of this study is to determine whether imaging, clinical or pathologic features
can be used to predict LN metastasis and suggest sentinel LN biopsy (SLNB) in patients
with biopsy-proven DCIS.
Images for this section:
Fig. 1
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Fig. 2
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Fig. 3
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Methods and Materials
1. Patient selection
- From March 2004 to December 2009
- 487patients with biopsy proven DCIS
2. Patient evaluation
- Clinical evaluation
- Imaging evaluation
- pathological evaluation
3. Statistical analysis
Images for this section:
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Fig. 1
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Fig. 2
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Fig. 3
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Results
1. LN evaluation and follow-up
2. Histological underestimation
3. Histological LN evaluation
4. Significant predictive factors
- on univariate analysis
- on multivariate analysis
5. ROC analysis
Images for this section:
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Fig. 1
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Fig. 2
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Fig. 3
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Fig. 4
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Fig. 5
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Fig. 6
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Fig. 7: A 44 year-old female with left breast bloody nipple discharge.
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Fig. 8: A 56 year-old female with screening abnormality.
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Conclusion
1. SLNB can be performed appropriately in patients with biopsy proven DCIS
2. SLNB is not indicated in all patients with biopsy proven DCIS
- Because of low incidence of axillary L metastsis in pure DCIS
- If the patient has biopsy proven DCIS which is large size on USG,
SLNB should be performed.
References
1. Mittendorf ME, Arciero CA, Gutchell V, et al. Core biopsy diagnosis of ductal carcinoma
in situ: An indication for sentinel lymph node biopsy. Current surgery 2005; 62(2):
253-257.
2. Takacs T, Paszt A, Szentpali K, el al. Importance of sentinel lymph node biopsy in
surgical therapy of in situ breast cancer. Pathol. Oncol. Res. 2009; 15: 329-333.
3. Goyal A, Douglas-Jones A, Monypenny I, el al. Is there a role of sentinel lymph node
biopsy in ductal carcinoma in situ?: analysis of 587 cases. Breast cancer research and
treatment 2006; 98: 311-314.
4. Hung WK, Ying M, Chan M, el al. The impact of sentinel lymph node biopsy in
patients with a core biopsy diagnosis of ductal carcinoma in situ. Breast cancer. 2009;
s12282-009-0164-2
5. Sakr R, Antoine M, Barranger E, el al. Value of sentinel lymph node biopsy in breast
ductal carcinma in situ upstaged to invasive carcinoma. The breast journal 2008; 14(1):
55-60.
Personal Information
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