ULTRASONIC IMAGING 10, 153-170 THE MALTeSE CROSS PROCESSOR: SPECKLE REDUCTION FOR CIRCULAR TRANSDUCERS S.W. Smith"2 and O.T. von Rannn3 'Center for Devices and Radiological Health Food and Drug Administration Rockville, MD 20857 *Department of Radiology Duke University Medical Center Durham, NC 27706 3Departmentof Biomedical Engineering Duke University Durham, NC 27706 new online signal processing technique is described to reduce speckle noise in ultrasound images. In the imaging system, a focused piston transducer is divided into thirty-two sectors. In the receive mode, parallel signal processing arranges the sectors into eight maltese crosses. The rf signals of the perpendicular arms of each cross are multiplied in a phase sensitive process. The orthogonal receive mode multiplication is designed to reduce side lobes resulting from the sector shapes while maintaining lateral resolution through the use of the full aperture diameter. The signals from the crosses are then combined via postdetection sumnation. Six of the eight crosses perform successfully. The six maltese crosses show decorrelated signals equivalent to four independent samples of the speckle noise which decreases noise contrast by a factor of two with no measureable loss of spatial resolution. Post summation compression is included to retain the conventional signal dynamic range. Parallel signal processing maintains the normal image line rate. Images of tissue-mimicking phantoms including speckle targets show improved detectability of simil.ated lesions. o 1988 Academic Press, Inc. A Key words: Resolution; signal-to-noise ratio; speckle reduction; ultrasound imaging. The topic of speckle interference in ultrasound images has received significant attention in the last decade. In 1978, Burckhardt [l] first 0161-7346/88 $3.00 153 Copyright 0 I988 by Academic Press, Inc. All rights of reproduction in any form reserved. Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 SMITH AND VON RAMM noted its existence in B-mode images and its analog to laser speckle. He also derived the first order statistics of speckle and described how to reduce speckle contrast in an ultrasound image through the technique of spatial compounding. That is, the average of N uncorrelated samples of an object volume from several independent transducer orientations in both the transmit and receive modes reduces the contrast of the speckle noise (increases the speckle signal-to-noise ratio, SNR) by N"* Since then, several investigators [2-41, including those from our own laboratories [5-71, have attempted to ameliorate the effects of speckle using spatial compounding in high speed linear phased arrays. . For the case of mechanically scanned circular transducers the topic of spatial compounding per se has received little attention [El. However, investigators at the University of Toronto [9,10] have achieved significant speckle reduction via signal processing techniques which are similar to spatial compounding. A single orientation of the transmit aperture was used, but the receive aperture is divided into several subapertures to obtain independent samples of the target volume. A hybrid transducer was used consisting of a spherically shaped, focused transducer combined with a concentric planar transducer disk and two aluminum mirrors. In their most recent work, both the spherical transducer and the planar disk were segmented into eight sectors which enabled several options for receive mode signal processing. In each of these techniques, a full circular aperture was used in the transmit mode with either the spherical transducer or the planar di-sk. In the receive m d e , the signal outputs from the eight sectors of either the spherical transducer or the planar disk were combined using multiplicative processing OK summation. The techniques included "phase insensitive sector addition," i.e., s, (t)=CN=8 2, (t) i=l where xi(t) are the RF signals from individual sectors of the array, R,(t) are the signals after envelope detection, and S,(t) is the sum of these signals for the N=8 sectors of the receive mode transducer. Other speckle reduction techniques evaluated have included multiplicative processing of the rf signals, i.e., 154 Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 MALTESE CROSS PROCESSOR and "phase insensitive sector multiplication", i.e., For each of these signal processing techniques, as well as for the schemes of spatial compounding with linear phased arrays, one must evaluate the trade-off of increasing speckle SNR versus loss of lateral resolution. For a given imaging task in the body, one must ask whether it is better to use the full transducer aperture with optimum lateral resolution in a simple scan, or to divide the aperture into N subapertures to achieve N independent samples of the speckle noise and increase the speckle SNR by (N)l'* while losing some lateral resolution. To our knowledge, there have been no published clinical studies to confirm the effectiveness of speckle reduction via spatial compounding. Instead, investigators have relied on various figures of merit in studies of phantoms to evaluate success of previous speckle reduction techniques. These figures of merit have included: 1) the point spread response of the imaging system, 2 ) the ratio of mean to standard deviation, ,u/u, the so-called signal-to-noise ratio of the speckle probability density function, 3 ) the crosscorrelation coefficient between samples of the speckle target volume, 4 ) measurements of the detectability of lesions in tissue mimicking materials such as contrast-detail diagrams and the area-wise signal-to-noise ratio [lll or the contrast-to-speckle ratio [91. In previous studies, there have been consistent losses of lateral resolution or image contrast as measured by the point spread response in exchange for the improvement in speckle SNR. In the present study, our goal was to develop an online signal processing technique for speckle reduction in conventional mechanical scanners which use focused piston transducers. We wished to minimize degradation of the transducer point spread response by the signal processor. McKechnie [12] had analyzed laser speckle reduction for a circular lens and recommended the time average signal of a rotating aperture shaped in the form of a Maltese cross to achieve speckle reduction. Since the length of each orthogonal a m of the cross is equal to the lens diameter, there is no apparent loss of lateral resolution as determined by the main lobe of the point response function. However, this geometry causes a significant loss of image contrast due to the increased side lobes of the response function. We believed that multiplicative processing of the orthogonal arms of the Maltese cross would maintain the point response function of the imaging system. 155 Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 SMITH AND VON RAMM In this paper, we describe the design and implementation of the Maltese cross processor which includes a multiplicative processing scheme and which has been incorporated into a commercial static B-scan system. We describe our preliminary measurements of the performance of the system in terms of its point spread response, the improvement in the speckle SNR ( p / u ) and improved images of speckle targets in tissue mimicking phantoms. We also discuss briefly its performance in terms of the more complex measures of lesion detection. Figure 1 illustrates the principles of the Maltese cross processor. A conventional focused piston transducer is segmented into 32 equal sectors. In the transmit mode, the 32 sectors are fired simultaneously by a single transmitter. Each sector and its opposite member, separated by 180°, is wired together at the transducer to form 16 "bar-tie" elements. The length of each element is equal to the transducer diameter. The element can be approximated by a long thin rectangle whose length is approximately 10 times its width. The receive mode rf signals from the horizontal element are multiplied by the signal from the orthogonal vertical element. The results of this product are illustrated qualitatively in figure 1 in terms of the contour map of the recei e mode point spread function. The main lobe of the diffraction pattern P ( y 6 ) of each element is approximated by sin B B Fig. 1 (4) conventional focused piston transducer is segmented into 16 "bar-tie" elements. The rf output of each element is multiplied by that of its orthogonal element to produce the Maltese cross. The product of the point spread responses of the horizontal and vertical elements (shaded areas) yields a response peaked on the origin with side lobes only on the x and y axis. A 156 Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 MALTESE CROSS PROCESSOR where a = nDsiny/X, y is the angle parallel to the length of the element relative to the axis of the transducer, f3 = n2Dsind/32X, and d is the angle parallel to the element width relative to the axis of the transducer. The side lobe amplitude of the receive mode diffraction pattern is determined by the "b-tie" apodization of each element and is significantly larger than that predicted by a sin X/X function. The contour map of the diffraction pattern of the shaded horizontal element is shown narrow in the x direction with two side lobes and broad in the y direction. Conversely, the diffraction response of the shaded vertical element is narrow in the y direction with two side lobes and broad in the x direction. The receive mode product of these two orthogonal diffraction patterns is strongly peaked at the origin with side lobe contributions only on the x and y axes. The same product is performed in parallel for each orthogonal pair of the sixteen elements resulting in rf signals from eight Maltese crosses. The signal from each cross is envelope detected in parallel and summed with the detected signal from the other crosses. The overall signal process is described by i=l where the bar now represents the envelope detection process. The side lobes for each cross occur at different angles without significant overlap. Because of the summation in Q. (5) and the lack of overlapping side lobes, the main lobe amplitude relative to the side lobe amplitude is increased by approximately a factor of eight compared to that of a single cross. The resulting overall receive mode response pattern is circularly symnetric with minimal side lobe contributions. The overall transmit-receive point response is further improved by the Airy disk pattern of the full circular transmit aperture. Figure 2 s h m , in detail, our hardware implementation of the Maltese cross processor and compares the conventional signal processing of the control case versus that of the Maltese cross for the same focused piston transducer. The signal processing techniques were implemented in parallel to enable simultaneous comparison of the resulting B-mode images. A 19 mm, 8 an radius of curvature, PZT-SA crystal, with nominal frequency of 2.25 MHz, was used to fabricate the transducer array. After dicing and backing, the array operated at a center frequency of 1.8 MHz. The receive mode rf 157 Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 SMITH AND VON RAMM 8 Crosses 32 Sectors Amplifiers Amplifiers Detectors/ LPF Summer Detector/ LPF Fig. 2 (A) Conventional signal processing for the control case. The rf output from each transducer element is summed before envelope detection and B-mode display. (B) Signal processing for the Maltese cross. The rf output of orthogonal arms of each cross is multiplied together. The output of each multiplier is envelope detected and summed. The sum undergoes logarithmic compression before B-mode display. signals from each of the 16 elements pass in parallel through one of 16 matched FET amplfiers contained in the transducer handle for the purpose of impedance matching. The signals then pass through one of 16 matched preamplifiers. The 16 preamplifiers were retrieved from a Grumman model RT400 phased array system no longer in clinical use. The Grumman preamplifiers with n;C produce 90 dB of gain over a dynamic range of 120 dB and a minimum noise level of 10 UV. shown in figure 2A, to achieve the equivalent of conventional processing for a single focused piston with no speckle reduction, we summed the 16 rf outputs from the preamplifiers in an Analog Devices model 465 operational amplifier. The summed signal then is envelope detected in t h e conventional manner. It should be noted that, other than envelope detection, the signal has undergone no nonlinear amplification such as logarithmic compression or reject up to this point. The detected signal is then sent to the analog scan converter of a Picker 8OL static B-scanner. The transducer array is mechanically connected to the articulated arm of the Picker device, but the arm and transducer are constrained to a simple linear scan format by a ball-bearing slide assembly which travels on rails above the water tank. As The Maltese cross processing of figure 2B is performed in parallel with the signal processing of the control case of figure 2A. The rf multiplication of the shaded horizontal arm times the shaded vertical arm is performed by an Analog Devices 429B multiplier. The output signal is 158 Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 MALTESE CROSS PROCESSOR then centered at 3.6 MHz. The 1.8 MHz feedthrough is reduced by 23 dB by a high pass filter following the multiplication. The output signal from the multiplier undergoes conventional envelope detection. The signals from the other seven crosses are obtained from parallel multipliers and envelope detectors. The detected signals from the eight crosses are then summed in an operational amplifier. The multiplicative operation of the Maltese cross signal processor doubles the signal dynamic range. We restored the original dynamic range by a postsumation logarithmic compression amplifier (30 dB to 20 dB) which approximates a square root operation. During fabrication of the transducer array, two adjacent sector elements (#31 and #32) failed so that in our preliminary evaluations we were left with six operating crosses. To ensure equivalent operation for the control case, we also disconnected the remaining transducer elements of those two failed crosses in receive mode. The point spread response of the Maltese cross signal processor was compared to that of the control for the lateral dimension by scanning the tip of a 1 mm stainless steel wire in a two dimensional rectilinear pattern in the transducer focal zone at a range of approximately 8 cm. The output signal from the tip of the wire target was sent to a Panametrics Model 5052UA peak detector, and the resulting dc level was digitzed and stored in a Hewlett-Packard model 21MX computer. We took care not to saturate the Panametrics peak detector or the logarithmic compressor of the Maltese cross processor. Because of the multiplicative operation of the Maltese cross, we were concerned about potential image artifacts resulting from cross product terms from multiple closely spaced specular targets. Therefore, we also compared the B-scans of an immersible MUM standard 100 m wire phantom [13] for the control case versus the Maltese cross. To evaluate the speckle reduction capabilities of the Maltese cross processor, we scanned tissue mimicking material. We used a slurry of 1 mm agar spheres in a 5 percent solution described by Madsen et al. [14] and obtained from RMI, Inc. Each sphere contained 20 pm graphite scatterers. We had recently used this material to develop a new version of the ultrasound contrast-detail phantom [15]. The slurry exhibits Rayleigh statistics and images of the material using clinical scanners operating without logarithmic compression or reject (linear mode) show a fully developed speckle pattern whose speckle SNR was approximately 1.91. We determined the cross-correlation coefficients between speckle signals from each of the six crosses for all possible nonredundant combinations of the Maltese cross signals. These include nearest 159 Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 SMITH AND VON RAMM neighbors, i.e., (N,N+1), N = 1,5, next nearest neighbors, (N,N+2), N = 1,4, etc. Note combinations with crosses #7 and #8 are omitted because of the dead elements. Because of the circular symmetry of the crosses, the combination (N,N+3) is equivalent to (N,N+5); (N,N+2) is equivalent to (N,N+6), etc. In making these measurements for each combination of crosses, we digitized a 4 cm range of envelope detected speckle signal centered about the transducer focal zone and stored the signal in a Tektronix 7854 digital oscilloscope. Crosscorrelation coefficients were determined using the waveform calculator of the oscilloscope and repeated for each pair of crosses. The coefficients were calculated using xj where and-Zj are the envelope detected echo at location j for line Y and Z,and Y and Z are the mean data values of line Y and 2 . Coefficient data were averaged for four independent regions of the tissue mimicking phantom. For each of these four data sets, we also calculated the speckle SNR for the control case and the Maltese cross processor. The SNR data were obtained for the speckle signals (A-mode lines) rather than from regions of interest in the corresponding B-mode images because we wished to exclude any nonlinear processing associated with the scan converter of the Picker system. To assess the effects of the logarithmic compressor in the Maltese cross processor, we compared the SNR data after compression versus that obtained using only the square root function in the Tektronix waveform calculator. Finally, we inserted into the slurry, negative contrast conical targets fabricated from lower concentrations of the agar sphere material. The cones had known object contrasts of -16 dB, -10 dB, and -3 dB previously measured on clinical scanners w i t h no logarithmic compression or reject, i.e., linear mode [15]. We obtained images of each cone in long axis to compare the image quality at the tip of the cone for conventional processing versus that of the Maltese cross. We also obtained short axis images of the cones to simulate a disk shaped lesion. 160 Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 MALTESE CROSS PROCESSOR 111. RESULTS Figure 3 compares the transmit-receive point response function for the control case versus the Maltese cross processor using both a 3-D graphic display and a contour map. The Maltese cross data was taken using the logarithmic compression to equalize signal dynamic range w i t h the cont r ol . The main lobe of the Maltese cross is seen to be narrower than that of the control processing. The -20 dB beam width of the Maltese cross measures 4 . 6 mm compared to 6.6 mm in the control. In the 3-D graphics display, there is some evidence of low level off-axis signal in the Maltese cross data. However, this is not seen in the contour maps out to a level of -20 a. The off-axis energy in the Maltese cross below -20 dB is not unexpected since the 1.8 MHz feedthrough from the multiplier was suppressed only 23 dB below the 3 . 6 MHz desired signal as noted above. Figure 4 compares the image quality of the control processing (left) versus the Maltese cross processor (right)using the MUM 100 mm wire phantom. The phantom had been turned on its side to use the lateral resolution wire targets at a range of 4.5 cm and to scan the axial resolution targets in the lateral direction at 8 cm range. We wanted to examine the possibility of crossproduct artifacts in the Maltese cross processor from closely spaced specular targets. There seems to be no evidence of such artifacts at least within the dynamic range of the imaging system. The Maltese cross shows a smaller point size at the 8 cm focal point as also evidenced by figure 3 and shows a slightly better lateral resolution of the closely spaced wires at 8 cm in range. Fig. 3 Comparison of measured transmit-receive point spread response functions of control processing ( A ) versus Maltese cross processing ( B). 161 Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 SMITH AND VON RAMM Fig. 4 Comparison of Emode images of AIUN loom test object by conventional signal processing (left) versus Maltese cross processing ( right). Figure 5 plots the crosscorrelation coefficients of speckle signals obtained for nonredundant combinations of the six Maltese crosses. The error bars shows 21 standard deviation for the measurement data. If the speckle signals from the six crosses were completely independent, one would expect the Maltese cross processor to increase the speckle S m by (6)”2 = 2.45. The partially correlated signals of figure 5 will result in less improvement. The increase in speckle SNR (,u/u) as a result of averaging m partially correlated speckle images has been described by Trahey et al. [7] and can 1.0 Fig. 5 0.0 L- FL u N+l N+2 N +3 N +4 Average cross-correlation coefficients of speckle signals from neighboring Maltese crosses measured in tissue mimicking material 162 Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 MALTESE CROSS PROCESSOR be calculated using where d (wk ) is the variance of image Wk and p ( w k ,Wj ) is the correlation coefficient of images Wk and W, [161. Note that the mean N remains constant in the averaging operation for equal original means. The data of figure 5 used in Q. ( 7 ) yield a predicted improvement in SNR by a factor of 1 . 5 9 (+.392/-.220). The values of the speckle SNR ( p / u ) for the control versus the Maltese cross processor were averaged for the four independent speckle patterns used to obtain the cross-correlation data above. The p / u data indicates a control value of 1 . 8 5 _+ .088 which is very close to the value ( 1 . 9 1 ) expected for Rayleigh statistics. The Maltese cross data show a value of 3.60 k.65 for the square root function of the Tektronix digital oscilloscope versus a value of 3.61 k . 2 5 for the online log compression circuit. The data are in close agreement indicating that the log compressor reasonably approximates a square root for this experiment . These results correspond to improvements in p / a by a factor of 1 . 9 4 which is in reasonable agreement with that predicted by Eq. ( 7 ) above (within 1 standard deviation). The increase in speckle SNR shows that the six partially correlated Maltese crosses yield improvement equivalent to approximately four independent samples of the speckle noise. Figures 6-9 show our preliminary imaging results comparing conventional signal processing with the Maltese cross signal processing for the six operating crosses. In figures 6-8, the conical targets, which are seen in long axis, include contrasts of -16 dB, -10 dB and -3 ds. In each case, the speckle shows significantly less contrast. Measurements of speckle SNR for individual lines in these images show approximately a factor of 2 increase as in the experiments described above. The smoother speckle background in each figure enhances the visibility of the targets. This is particularly true of the low contrast, -3 de target in figure 8 which is almost undetectable in the control image. Likewise, figure 9 showing the -10 dB cone in short axis at a diameter of 1.8 cm, demonstrates reduced speckle contrast and improved detectability for the Maltese cross processing. 163 Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 SMITH AND VON RAMM Pig. 6 Comparison of long axis B-mode images of conical speckle target irrrmersed in speckle background for conventional processing (left) versus Maltese cross processing (right). Target contrast is -16 dB. IV. DISCUSSION We have described the design and implementation of the Maltese cross signal processor which increases speckle SNR while maintaining lateral Fig. 7 Comparison of long axis B-mode images of conical speckle target immcrsed in speckle background for conventional processing (left) versus Maltese cross processing (right). Target contrast is -10 dB. 164 Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 MALTESE CROSS PROCESSOR Fig. 8 comparison of long axis B-mode images of conical speckle target inmersed in speckle background for conventional processing (left) versus Haltese cross processing (right). Target contrast is -3 dB. resolution for mechanically scanned circular transducers. Due to the multiplicative signal processing of orthogonal arms of each cross, measurements using the point spread response and the MUM test phantom showed no loss of lateral resolution for the Maltese cross. For the six operating Maltese crosses, measurements of speckle SNR showed an improvement of approximately a factor of two which is equivalent to four Fig. 9 images of conical speckle target Comparison of short axis imnersed in speckle background for conventional processing (left) versus Maltese cross processing (right). Target contrast is -10 dB. 165 Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 SMITH AND VON RAMM independent samples of the speckle noise. In addition, images of high and low contrast targets show improvement in the detectability of such objects. With these preliminary evaluations of the mltese cross, we can discuss more complex figures of merit for the problem of lesion detection in medical ultrasound. We have previously proposed a theoretical model [ll] for the detection of low contrast lesions which yields an area-wise SNR where C is the lesion contrast, d the lesion diameter, N the number of independent samples of the speckle pattern via spatial or frequency compounding, Scx is the speckle size in the lateral direction which is proportional to the lateral resolution and S c z the speckle size in the axial direction. Using Eq. (7), for high speed spatial compounding with a one-dimensional linear array, Trahey et al. [17] have found a maximum of 3.2 independent samples (N = 3 . 2 ) of the speckle for a factor of two loss of lateral resolution, i.e., Scx increased by a factor of 2. By Eq. ( a ) , then, the increase in area-wise SNR for spatial compounding is ( 3 . 2 / 2 ) 1 ' 2 = 1.26. Patterson et al. [91 proposed the contrast-to-speckle ratio as a measure of cyst detection in a speckle background, i.e., si - so CSR = (Ui 2 + P2 uo2 where, for many independent image planes of a cylindrical cyst, Si is the mean signal inside the cysts, So is the mean signal outside the cysts, ui2 is the variance of the many measurements inside the cysts and uo2 is the variance of the measurements outside the cysts. Kerr et al. [lo] have shown experimentally that for the signal processing techniques discussed in Equations (1) to (3) above, the best processor is the "phase insensitive sector addition" of Eq. (1) which yields experimental results showing a factor of 1.66 increase in CSR. Using the data of Patterson et al. 191, we have shown previously [181 that the CSR parameter is approximately equivalent to our areawise SNR. Thus, 166 Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 MALTESE CROSS PROCESSOR we can also use the data of Kerr et a1 in Eq. ( 8 ) . e.g. for 8 approximately independent sectors (N=8), there is approximately a factor of three loss of lateral resolution, i.e., SCx increased by a factor of three. The increase in the theoretical areawise SNR of Fq. 8 is then (8/3)1'2= 1.63, which is in agreement with the experimental results of Kerr et al. In the case of the Maltese cross, the six operating ccosses are partially correlated and yield the equivalent of four independent samples of the speckle pattern (N = 4 ) . As a result of the multiplicative processing of the orthogonal arms, there is evidently no loss of lateral resolution as measured by the point response function. Thus, our model for low contrast lesion detection (Eq. 8) predicts a factor of two improvement in areawise SNR or CSR. Of course, this preliminary estimate needs to be confirmed by lesion detection measurements. There are two other interesting features of the Maltese cross processor. First, unl i k ~s p a t i a l compounding systems using siihavrtnres in a phased linear array, there seems to be little compounding improvement for specular targets for the Maltese cross. This is seen in the image of the MUM test phantom (Fig. 4 ) . Our preliminary Maltese cross images of cone targets, which show a specular boundary due to trapped air, also show only a slight improvement in the specular echoes. The second difference from linear array systems is in the area of data acquisition rate. High speed spatial compounding using N apertures require N parallel processors to maintain real time image acquisition. We have previously developed such a system [6] for spatial compounding in a phased linear array which produced four independent receive lines for a single transmit burst, but required four independent delay line prisms and associated circuitry for each transducer channel. The Maltese cross processsor, for a single focused piston transducer, requires only the parallel multipliers and detectors for each cross to maintain adequate data acquisition rate to achieve real time imaging. Of course, there are still significant areas for improvement in the Maltese ccoss processor. Our most significant problem during fabrication was electrical and acoustic crosstalk between array elements which caused high correlation coefficients between the six crosses. We eliminated much of the electrical crosstalk by joining the array sectors to their 180" opposite numbers on miniature circuit boards mounted on the transducer with careful attention to ground planes. However, we believe a significant component of the high correlation coefficients between neighboring crosses, shown in figure 5, is still due to crosstalk. 167 Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 SMITH AND VON RAMM The available signal dynamic range of the Maltese cross needs to be increased through the use of a better high-pass filter to suppress the feedthrough in the multiplicative operation. Alternatively, digital multiplication of the rf signals would eliminate the feedthrough problem. When the feedthrough problem is solved, the side lobe levels in the multiplicative processor need to be studied out to -FO& to examine possible off axis energy which would degrade the image contrast. Alternatively the side lobe levels can be investigated through theoretical analysis and computer simulation. The Maltese cross processor should be implemented on a real time system to enable clinical trials. Such a next step could be achieved by modifying a simple mechanical sector scanner with a fixed focus piston transducer to produce as many crosses as desired. For example, if we use conventional fabrication techniques for transducer arrays, it is possible to segment the 19 nun circular crystal into as many as 128 sectors which would produce 32 Maltese crosses. Based on the results of our crosscorrelation measurements in figure 5, we would expect the equivalent of approximately 20 independent samples of the speckle noise which would increase the speckle SNR by a factor of 4.5, presumably with no loss in lateral resolution. Alternatively, a more complex approach would be to modify a phased array beam former to develop a mechanically steered Maltese cross/annular array. For example, assuming a typical 64 channel system, one could produce a four element annular array and eight Maltese crosses. However this system would require 64 short delay lines for focusing and 16 multipliers and detectors. In either case, the Maltese cross shows the promise of speckle noise reduction with minimal compromise of spatial resolution for improved image quality. ACKNOWLEDGEMENTS We are grateful to David L. Daley of the Center for Devices and Radiological Health for his assistance in circuit development. Disclaimer The mention of commercial products, their source, or their usein connection with material reported herein is not to be construed as either an actual or implied endorsement of such products by the Department of Health and Human Services. REFERENCES [l] Burckhardt, C.B., Speckle in ultrasound B-mode scans, IEEE Trans. Sonics Ultrason. E 5 , 1-6 (1978). 168 Downloaded from uix.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2016 MALTESE CROSS PROCESSOR [2] Carpenter, D.A., Dadd, M.J., and Kossoff, G., A multimode real time scanner, Ultrasound Med. and Biol. -6, 279-284 (1980). [3] Berson, M., Roncin, A., and Porcelot, L., Compound scanning with an electrically steered beam, Ultrasonic Imaging 1, 303-308 (1981). [41 Ligtvoet, C.M., and Eversdijk, C.H., Real Time Compound Scanning, in Excerpta Medica, No. 553, pp. 51-55, International Congress Series, Amsterdam, (19811 . [5] Shattuck, D.P. and von Ramm, O.T., Compound scanning with a phased array, Ultrasonic Imaging -4, 93-107 (1982). [61 Shattuck, D.P., Weinshenker, M.D., Smith, S.W., and von Ramm, O.T., Explososcan: a parallel processing technique for high speed ultrasound imaging with linear phased arrays, J. Acoust. SOC. Amer. - - 75, 1272-1282, (1984). [7] Trahey, G.E., Smith, S.W. and von Ramm, O.T., Speckle pattern correlation with lateral aperture translation: experimental results and implications for spatial compounding, IEEE Trans. Ultrasonics, Ferroelec. Freq. Control UFFC-33, 257-264, (1986). [8] Matzuk, T. and Skolnick, M.L., Real Time Compound Scanner Using Four Servo Controlled Transducers, in Proc. Ann. Meeting, AIUM p. 184 (abstract only) (AIUM, Bethesda, MD 1979). [9] Patterson, M.S. and Foster, F.S., Improvement and quantitative assessment of B-mode images produced by an annular array/cone hybrid, Ultrasonic Imaging 2, 195-213, (1983). [lo] Kerr, A.T., Patterson, M.S., Foster, F.S., and Hunt, J.W., Speckle reduction in pulse echo imaging using phase insensitive and phase sensitive signal processing techniques, Ultrasonic Imaging g, 11-28 ( 19861. [ll] Smith, S.W., Wagner, R.F., Sandrik, J.M. and Lopez, H., Low Contrast Detectability and Contrastmtail Analysis in Medical Ultrasound, IEEE Trans. Sonics Ultrasonics SU-30, 164-173, (1983). [12] McKechnie, T.S., Speckle Reduction, in Laser Speckle and Related Phenomena, pp. 123-170, J.C. 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