Common Medication-Medication Interactions in Long Term Care
Medication 1
Medication 2
Impact
warfarin
NSAIDs such as ibuprofen,
naproxen, COX-2 inhibitors
sulfonamides such as
trimethoprim/
sulfamethoxazole
macrolides such as
clarithromycin,
erythromycin
fluoroquinolones such as
ciprofloxacin, levofloxacin,
ofloxacin
phenytoin
Potential for serious
gastrointestinal bleeding
Increased effects of
warfarin, with potential for
bleeding
Increased effects of
warfarin, with potential for
bleeding
Increased effects of
warfarin, with potential for
bleeding
Increased effects of warfarin
and/or phenytoin
Elevated serum potassium
levels
warfarin
warfarin
warfarin
warfarin
ACE Inhibitors such as
benazepril, captopril,
enalapril, and lisinopril
ACE Inhibitors such as
benazepril, captopril,
enalapril, and lisinopril
digoxin
digoxin
theophylline
potassium supplements
spironolactone
Elevated serum potassium
levels
amiodarone
verapamil
fluoroquinolones such as
ciprofloxacin, levofloxacin,
ofloxacin
digoxin toxicity
digoxin toxicity
theophylline toxicity
Transmittal 22 Excerpt Med Int
Jan 07
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