Quiz 11 Review Sheet­ Complete the following review sheet, in addition to review your notes, to help prepare for the quiz on May 22. Pedigree Practice: refer to your notes for the appropriate symbols. 1. Joe is married to Karen and they have four children, Sue, Monica, Erika, and Jeb. A. Draw the pedigree of this family in the space below. B. Joe, Jeb, and Monica have brown hair. Show this in your pedigree. C. Suppose the allele for brown hair (B) is dominant to the allele for blonde hair (b). List the genotypes of each individual shown in the pedigree. This is an autosomal dominant trait. 2. George is married to Alice and they have four children­ Tom, Sally, Mark, and Amy. When Amy grew up she met Bill and they got married. Bill is the sibling of Sara and Samuel. Bill’s mother is Dixie and his father is Gary. Amy and Bill have three children­ Kyle, Ashley, and Jenna. A. Draw the pedigree of the family described above. Be sure to record their names below each symbol. B. George has dimples but Alice and their children do not. The only member of Bill’s family with dimples
is Sara. Kyle and Jenna both have dimples. C. What are Dixie and Gary’s genotypes? Suppose the allele for dimples is “d”. This is an autosomal recessive trait. D. Can Bill and Amy be homozygous for dimples? A & B (see pedigree) C. Dixie­ Dd, Gary­ Dd D. No, they can not be homozygous because they do not have dimples but there children do. 3. Does the pedigree to the right depict a X­linked trait? Explain. Pedigree A Yes, because affect males do not pass it on to their sons. 4. Is this trait shown in pedigree A dominant or recessive? Explain. Recessive because there are carriers 5. Add the genotypes to the individuals shown in the “Autosomal Dominant” pedigree. Use B for the dominant allele and b for the recessive allele. Note­ this is not sex linked. 6. Why are there no carriers? Because this is autosomal dominant meaning, as long as the person is a carrier of the dominant allele, they will be affected by the trait. The Roberts and Carson families were tested for the ∆508 mutation, a mutation associated with cystic fibrosis (CF). The results are shown in the pedigree chart. Fill in Sally’s result based on your testing. Construct a Punnett Square for Ann and Bill and for Karen and Dan. Use C for the dominant normal allele and c for the recessive defective allele. What were the chances of Ann and Bill having a child with CF? ______25%______ What were the chances of Karen and Dan having a child with CF? ______0%______ Barbie and Ken have been referred to you for genetic counseling. What can you tell them about their daughter Sally? Their daughter will have a 25% chance of having CF. There is also a 50% that she will carry the allele.