DDT Author: Janice King Jensen Office of Pesticide Programs (7506C) U.S. Environmental Protection Agency 1200 Pennsylvania Avenue, NW Washington, DC 20460 United States of America Tel: 703-305-7706 Fax: 703-308-1850 E-mail: [email protected] 1 CONTENTS 1.0 EXECUTIVE SUMMARY See above page 1 2.0 INTRODUCTION page 4 2.1 Protocol Requirement page 4 3.0 DDT PRODUCTION, USE, AND CONTROL ACTIONS IN THE UN-ECE REGION page 5 3.1 Production page 5 3.2 Use page 5 3.3 Disposal page 5 3.4 Control Actions page 6 4.0 GLOBAL PRODUCTION AND USE OF DDT page 6 4.1 Global Production page 6 4.2 Global Use page 6 5.0 REVIEW OF THE AVAILABILITY AND FEASIBILITY OF ALTERNATIVES TO DDT page 6 5.1 WHO Action Plan to Reduce Reliance on DDT page 6 5.2 Use of Combination Vector and Disease Management Strategies page 7 5.3 WHO Pesticide Evaluation Scheme page 7 5.4 Use of Chemical Pesticides page 8 6.0 OTHER INFORMATION page 9 6.1 Economic Analysis of Malaria Control in Sub-Saharan Africa page 9 6.2 GEF Projects to Phase-Out DDT in Mexico, Central America, & Africa page 9 6.3 World Bank Loans to India page 9 6.4 Guidance from WHO, UNEP, & FAO with the Global IPM Facility Activities on Alternative Strategies for Sustainable Pest & Vector Management page 9 7.0 CONCLUSIONS 8.0 REFERENCES page 10 page 10 ATTACHMENTS 1. LRTAP POPs Protocol Obligations for DDT page 12 2. DDT Production and Use in the UN-ECE, responses from LRTAP Parties page 13 3. The Stockholm Convention: Information on Global DDT Production and Use page 15 2 2.0 INTRODUCTION This dossier reviews the availability and feasibility of alternatives to DDT. Most countries in the UN-ECE region have ceased production and use of DDT, and malaria is not a significant health problem in much of the region. However, DDT continues to be a tool outside of the region for the control of malaria. DDT has been used in the control of several diseases such as malaria, encephalitis, leishmaniasis, dengue, typhus, and plague, but today the main use of DDT is for malaria control. According to the WHO, malaria kills at least one million people each year, or about 3,000 people a day. Almost 300 million people suffer from acute malaria each year. Forty percent of the world’s population live in areas with malaria risk but nine out of ten cases occur in Africa south of the Sahara. For additional information on malaria, see http://www.rbm.who.int. 2.1 Protocol Requirement The Protocol to the Convention on Long-Range Transboundary Air Pollution (LRTAP) on Persistent Organic Pollutants, or the POPs Protocol, requires Parties to eliminate the production and use of DDT once there is consensus that suitable alternatives are available for public health protection. Parties are required to review, no later than one year after entry into force and periodically thereafter, and in consultation with WHO, FAO, and UNEP, the availability and feasibility of safer and economically viable alternatives to DDT, and, as appropriate, promote the commercialization of safer and economically viable alternatives to DDT. As the POPs Protocol has not yet entered into force (only nine of sixteen required states have ratified as of June 15, 2002), this document should be considered a working draft. The POPs Protocol also restricts the use of DDT as a chemical intermediate to produce the pesticide dicofol, requiring the use be reassessed no later than two years after entry into force of the Protocol. This reassessment is not part of this report as it will be addressed elsewhere. For the complete text of the implementation requirements for DDT in Annexes I and II, see attachment 1. For the full text of the POPs Protocol, see http://www.unece.org/env/lrtap/ 3.0 DDT PRODUCTION, USE, AND CONTROL ACTIONS IN THE UN-ECE REGION The information for this section comes from two sources: 1) three questionnaires sent to LRTAP Parties in 2000 and 2001, compiled by the United States and included as attachment 2; and 2) the Stockholm Convention on Persistent Organic Pollutants. For more information, see attachment 3 or http://www.chem.unep.ch/pops/ 3.1 Production 3 During the negotiations for the Stockholm Convention on Persistent Organic Pollutants, the Russian Federation requested an exemption to produce DDT for disease vector control. No other UN-ECE country requested to produce DDT. 3.2 Use During negotiations for the POPs Protocol, the Russian Federation was the only UN-ECE country that requested that it be allowed to use DDT to control encephalitis. This continued need has not been reconfirmed. In their response to the 2001 UN-ECE Questionnaire, Georgia stated that the use of DDT was banned. Georgia, however, reported that it is aware of, and attempting to control, the unsanctioned use of DDT in coastal areas, military zones, and in certain facilities in Georgia. 3.3 Disposal The only information on stockpiles of DDT in the UN-ECE region is included below: Country Tons of DDT Notes/Reference Estonia 5.8 Response to July 2001 questionnaire Latvia 172 Included in Estonian response to July 2001 questionnaire Lithuania 80 Included in Estonian response to July 2001 questionnaire Moldova 0.3 & 654.1 Response to July 2001 questionnaire reported the following: Inventory in year 2000, DDT stocks in stockpiles contain 0.300 tons. All forms of DDT in Vulcanesti pesticide dump site are 654.1 tons, including technical DDT - 107.5 tons; DDT-5.5% - 187.7 tons; DDT 30% - 318.9 tons; DDT-75% - 22.6 tons; DDT 15% - 3.1 tons; and DDT Paste - 14.3 tons. Poland 400 Response to 2000 questionnaire 3.4 Control actions The specific control actions taken by UN-ECE countries are included in attachment 2. 4.0 GLOBAL PRODUCTION AND USE OF DDT Although not specifically required for this review, additional information is provided on the Stockholm Convention and global production and use of DDT. The Stockholm Convention allows the production and use of DDT for disease vector control until 4 effective and affordable alternatives become available; encourages the development of safe, effective, affordable and environmentally friendly alternatives; and establishes a DDT registry of users and producers that will be publicly available. Beginning with the first meeting of the Conference of Parties and every three years thereafter, Parties will, in consultation with the WHO, evaluate the continued need for DDT for disease vector control on the basis of available scientific, technical, environmental, and economic information 4.1 Global Production China, India, and the Russian Federation have submitted requests to produce DDT for public health purposes during the negotiations for the Stockholm Convention. 4.2 Global Use To date, thirty-two countries have requested to use DDT for disease vector control in accordance with the provisions for acceptable use during the negotiations for the Convention. These countries are listed in attachment 3. 5.0 REVIEW OF THE AVAILABILITY AND FEASIBILITY OF ALTERNATIVES TO DDT This section provides a general discussion on various malaria control strategies that include, inter alia, vector control, disease control, use of insecticide-treated bednets, malaria vaccines, and other control measures. For detailed information on these topics, the reader should consult the websites included in each section. The WHO, through its Roll Back Malaria initiative, has the international mandate to assist countries to reduce their reliance on DDT. 5.1 WHO Action Plan to Reduce Reliance on DDT Under its Roll Back Malaria initiative (RBM), the WHO has initiated a program to reduce reliance on DDT, including the development of the WHO Action Plan for Reducing Reliance on DDT. For more information, see http://www.rbm.who.int. This program provides an international framework for coordinating action with respect to DDT. RBM is developing a standard needs assessment methodology for use by national governments to identify the managerial, technical, and financial requirements to improve malaria vector control and reduce reliance on DDT. Based on these needs assessments, WHO will support countries in the preparation of national action plans that establish integrated strategies for enhancing malaria control while reducing reliance on DDT. 5.2 Use of a Combination of Vector and Disease Management Strategies Numerous factors specific to individual countries contribute to the continued use of DDT and the selection of vector control strategies. These include, inter alia, the incidence of malaria, vector dynamics, level of mobilization of health and vector control services, and available resources. Furthermore, vector control is only one component of malaria control. Direct medical interventions, particularly disease detection and treatment, are also essential and, in some 5 situations, are more cost-effective. In light of this country-specific variability, it is unlikely that one single strategy will be adequate for controlling malaria. Therefore, the WHO supports the development and use of a combination of vector and disease management strategies, called Integrated Vector Management, or IVM, for public health pests, not simply the replacement of DDT with another indoor vector control pesticide. For additional information, see http://mosquito.who.int/docs/ecr20.pdf and http://www.chem.unep.ch/pops/pdf/redelipops/redelipops.pdf In place of DDT, countries have relied on other chemical insecticides, biological controls, personal protective measures, and environmental management strategies. In some cases, these can be effective alternative strategies. However, many countries do not have adequate resources or capacity to conduct effective vector control programs using DDT or alternatives. Therefore, additional tools are needed that are safe, affordable, cost-effective, appropriate under local circumstances, and consistent with IVM. This will require concerted international action and resources to support research and development as well as training activities. For information on alternative vector control strategies, see http://www.who.int/dsa/cat98/vect8.htm#Vector Control. Other efforts underway, spearheaded by the WHO, international donor agencies, and research institutions include the development of malaria vaccines as well as new drug treatments, the development of non-chemical vector control tools, the strengthening of health services and technical capacity at the national level, and the promotion of insecticide-treated bednets. The United States Agency for International Development has recently published an environmental assessment on the use of insecticide-treated bednets in Sub-Saharan Africa. For more information on bednets, see http://www.encapafrica.org/sectors/pestmgmt.htm and http://www.afr-sd.org/SDPublications.htm 5.3 WHO Pesticide Evaluation Scheme The WHO Pesticide Evaluation Scheme, set up in 1960, is a key international program which promotes and coordinates the testing and evaluation of new pesticides proposed for public health use. It functions through the participation of representatives of governments, the pesticide industry, the WHO collaborating centers and university associations, associate laboratories as well as other WHO Programs. Through this program, the WHO has identified several pesticides that meet the WHO guidelines for malaria control. For additional information, see http://www.who.int/ctd/whopes/index.html 5.4 Use of Chemical Pesticides Several pesticides are routinely used for vector control in place of DDT. A cost-comparison of DDT and alternative insecticides for malaria control was published in 2000 and is included below. 6 1998-1999 cost comparison of insecticides for indoor vector control, excluding operational costs. (Adapted from Walker, 2000) Insecticide chemical name (SP = synthetic pyrethroid) Product cost range per house per 6 months (US$) ratio based on number in bold Cost ratio (DDT = 1) DDT 1.50 - 3.00 1 Malathion 3.20 - 6.40 (4.08) 1.4 Lamda-cyhalothrin (SP) 3.75 - 4.5 (4.51) 1.5 Cyfluthrin (SP) 2.20 - 5.50 1.8 Deltamethrin (SP) 3.20 - 8.00 2.7 Etofenprox 4.00 - 12.00 (8.00) 2.7 Bendiocarb 4.00 - 10.00 (8.00) 2.7 Permethrin (SP) 2.8 - 13.60 4.5 Fenitrothion 7.70 - 15.40 5.1 Propoxur 28.00 - 56.00 18.7 Though these pesticides offer alternatives to DDT, 1998 to 1999 global cost evaluations indicate DDT to still be the least expensive on a cost per house sprayed basis. However, the most cost effective insecticide in any given country or region must be determined on a case-by-case basis. The decision to use DDT or another insecticide for vector control may be influenced by several factors, particularly local efficacy and cost. The heavy use of a particular insecticide, either for vector control or in agricultural areas where disease vectors breed, may cause vectors to develop resistance to that insecticide. Insecticide resistance has led to the decline in efficacy of DDT against malaria vectors in Central America and some regions of India. Conversely, the development of resistance to synthetic pyrethroid insecticides in a vector species in South Africa has prompted a return to the use of DDT. High costs and market access may also limit insecticide choice. 6.0 OTHER INFORMATION 6.1.1 Economic Analysis of Malaria Control in Sub-Saharan Africa Although it does not address DDT specifically, the Global Forum for Health Research in conjunction with WHO published a report entitled An Economic Analysis of Malaria Control in Sub-Saharan Africa. The report analyzes the cost-effectiveness and economic benefits of a variety of malaria control interventions to countries in sub-Saharan Africa, for the purposes of providing policy-makers with information on the interventions which represent the best value for money. For information, see www.who.int/tdr/publications/tdrnews/news63/gfhrpublication.htm 7 6.2 GEF Projects to Phase-Out DDT in Mexico, Central America, and Africa The Global Environmental Facility (GEF) has established mechanisms to promote international co-operation and foster actions in providing additional grant and concessional funding to developing countries. The GEF has funded preliminary work in Mexico and Central America to phase-out DDT. A similar GEF project is being developed by WHO for countries in Africa. This project has been submitted to the GEF for consideration. These projects will focus efforts on developing alternative control strategies that are tailored to the needs of these regions. 6.3 World Bank Loans to India In a separate effort, the World Bank has provided a substantial loan to India to strengthen its malaria control program that will include the promotion of selective vector controls, including non-chemical methods and reduced chemical applications. As India presently uses more than half of the total DDT produced annually, this project may have a significant impact on DDT use overall. For information, see http://www4.worldbank.org/sprojects/Project.asp?pid=P010511 6.4 Guidance from WHO, UNEP, and FAO with the Global IPM Facility on Alternative Strategies for Sustainable Pest and Vector Management With nine of the twelve substances included in the Stockholm Convention on POPs being pesticides, WHO, UNEP and FAO with the Global IPM Facility have jointly developed guidance on alternative strategies for sustainable management of disease vectors and pests including termites, to assist countries in reducing and eliminating the use of persistent organic pesticides. This guidance focuses on the importance of integrated management approaches and inter-sectoral collaboration instead of simple replacement of POPs pesticides with another chemical and clarifies problems associated with approaches that solely rely on chemical control measures. Other activities include the establishment of a UNEP/FAO/Global IPM Facility Expert group termite biology and management that has produced one report and developed web-pages addressing aspects of alternative management approaches for control of termites within the agricultural and construction sectors. Further information can be obtained at http://www.chem.unep.ch/pops 7.0 CONCLUSIONS DDT is not produced or used by most countries in the UN-ECE region, nor is malaria a significant health problem in the region at this time. However, based on global information from the Stockholm Convention, China, India, and the Russian Federation have submitted requests to produce DDT for public health purposes and 32 countries have requested to use DDT for disease vector control. Several pesticides are routinely used for vector control in place of DDT. Cost data indicate that DDT is the least expensive on a cost per house basis. However, the most cost-effective insecticide in any given country or region must be determined on a case-by-case basis. Insect resistance, high cost and market access may limit insecticide choice. 8 In place of DDT, some countries have relied on other chemical insecticides, biological controls, personal protective measures such as insecticide-treated bednets, and environmental management strategies. Disease control interventions, particularly early diagnosis and treatment of malaria, are essential and, in some situations, are more cost-effective than vector control programs. For the purposes of the review required in Annex 1 of the LRTAP POPs Protocol, safer and economically viable alternatives to DDT continue to be needed for public health protection from diseases such as malaria. 8.0 REFERENCES FAO, 2002. Information submitted by the Food and Agriculture Organization of the United Nations to the Intergovernmental Negotiating Committee for the Stockholm Convention at the sixth session, UNEP/POPs/INC.6/INF/24. http://www.chem.unep.ch/sc/documents/meetings/inc6/englishonly/INC6_INF24.pdf Global Forum for Health Research, 2000. Economic Analysis of Malaria Control in Sub-Saharan Africa, by Catherine Goodman, Paul Coleman, Anne Mills, Global Forum for Health Research, published in conjunction with the World Health Organization, Geneva, Switzerland. http://www.who.int/tdr/publications/tdrnews/news63/default.htm Morner,J, R. Bos, M. Fredrix, 2002. Reducing and Eliminating the use of Persistent Organic Pollutants, Guidance on alternative strategies for sustainable pest and vector management, coproduced by the Food and Agriculture Organization of the United Nations, the World Health Organization, the United Nations Environment Program, and the Global IPM Facility, Geneva, Switzerland. http://www.chem.unep.ch/pops/pdf/redelipops/redelipops.pdf Najera, J.A. and M. Zaim, 2001. Malaria Vector Control, Insecticides for Indoor Residual Spraying, WHO/CDS/WHOPES/2001.3, Geneva, Switzerland. http://www.who.int/dsa/cat98/vect8.htm#Vector Control UNECE, 2000.The 1998 Protocol on Persistent Organic Pollutants, replies to questions 37-49 in the 2000 questionnaire, prepared by the UN-ECE secretariat from submissions by the Parties, Geneva, Switzerland. http://www.unece.org/env/documents/2000/eb/eb.air.2000.1.add.1.e.pdf UN-ECE,2001. The 1998 Protocol on Persistent Organic Pollutants, replies to question B of the 2001 questionnaire, prepared by the UN-ECE secretariat from submissions by the Parties, Geneva, Switzerland. UN-ECE, 1998. Protocol to the Convention on Long-Range Transboundary Air Pollution (LRTAP) on Persistent Organic Pollutants. http://www.unece.org/env/lrtap/ UNEP, 2000. The Stockholm Convention on Persistent Organic Pollutants, the United Nations Environment Program, Geneva, Switzerland. www.chem.unep.ch/pops UNEP, 2001. Conference of Plenipotentiaries on the Stockholm Convention on Persistent Organic Pollutants, revised list of requests for specific exemption in Annex A and Annex B and 9 acceptable purposes in Annex B, Stockholm, Sweden, 22-23 May 2001. http://www.chem.unep.ch/sc/documents/meetings/dipcon/25june2001/inf1rev3/k0122169.doc USAID, 2002. Programmatic Environmental Assessment for Insecticide-Treated Materials in USAID Activities in Sub-Saharan Africa, United States Agency for International Development, Washington, DC. http://www.afr-sd.org/SDPublications.htm Walker, K., 2000. Cost-comparison of DDT and alternative insecticides for malaria control, Medical and Veterinary Entomology, 14, 345-354. WHO, 1997. Vector Control, Methods for use by individuals and communities, prepared by Jan A. Rozendaal, World Health Organization, Geneva, Switzerland. http://www.who.int/dsa/cat98/vect8.htm#Vector Control WHO, 2000. Action plan for the reduction of reliance on DDT in disease vector control, WHO/SDE/WSH/01.5. World Health Organization, Geneva, Switzerland. http://www.rbm.who.int WHO, 2000. WHO Expert Committee of Malaria, WHO Technical Report Series 892, World Health Organization, Geneva, Switzerland. http://mosquito.who.int/docs/ecr20.pdf WHO, 2000. Malaria, a global crisis. Fact sheet 1: The problem. World Health Organization, Geneva, Switzerland. http://www.rbm.who.int WHO, 2002. WHO Pesticide Evaluation Scheme. http://www.who.int/ctd/whopes/index.html World Bank, 1997. Malaria control project in India (project number P010511), World Bank, Washington, DC, USA. http://www4.worldbank.org/sprojects/Project.asp?pid=P010511 10 Attachment 1 LRTAP POPs Protocol Obligations for DDT (For the full text of the POPs Protocol, see http://www.unece.org/env/lrtap/) Annex I -- Substances Scheduled for Elimination Substance DDT Implementation Requirements Elimination of Conditions Production 1. Eliminate production within one year of consensus by the Parties that suitable alternatives to DDT are available for public health protection from diseases such as malaria and encephalitis. 2. With a view to eliminating the production of DDT at the earliest opportunity, the Parties shall, no later than one year after the date of entry into force of the present Protocol and periodically thereafter as necessary, and in consultation with the World Health Organization, the Food and Agriculture Organization of the United Nations, and the United Nations Environment Programme, review the availability and feasibility of alternatives and, as appropriate, promote commercialization of safer and economically viable alternatives to DDT. None, except as identified in annex II. CAS: 50-29-3 Use Annex II -- Substances Scheduled for Restrictions on Use Implementation Requirements Substance DDT CAS: 50-29-3 Restricted to uses Conditions 1. For public health protection from diseases such as malaria and encephalitis. 2. As a chemical intermediate to produce dicofol. 1. Use allowed only as a component of an integrated pest management strategy and only to the extent necessary and only until one year after the date of the elimination of production in accordance with annex I. Use None, except as identified in annex II. 2. Such use shall be reassessed no later than two years after the entry into force of the present Protocol 11 Attachment 2 DDT Production and Use in the UN-ECE DDT Responses from LRTAP Parties 1 Compiled by the United States Environmental Protection Agency, February 2002 Country Production Use Republic of Armenia Austria banned in 1970 banned in 1992 banned in 1970 banned Belgium banned banned for use in agriculture in 1974, non-ag use banned in 1976. Republic of Bulgaria no production banned by 1990 Canada no production no use Czech Republic no production no use Croatia Banned banned Denmark Banned use banned in 1995 Estonia banned in 1968 last used in 1971 Finland no production banned in 1976 Georgia no production although officially banned, small scale use continues for Atraditional@ Soviet uses of DDT in coastal areas, military zones, and facilities. Georgia is attempting to control this use. Germany banned in 1972, amended in 1986 banned in 1972, amended in 1986 Greece Banned banned Italy no production banned in 1978 Kazakhstan no production no use Latvia no production banned in 1967 Cyprus France Hungary Iceland Ireland Liechtenstein Lithuania Luxembourg Republic of Moldova never produced use in agriculture banned in 1970 Monaco no production no use The Netherlands Norway production banned no production banned banned in 1989 Poland produced in 50', 60's, no current production use in agriculture banned in 1991 Slovenia no production banned in 1975 Spain no production banned in 1994 Sweden no production banned in 1970, except forestry use that was banned in 1974 Switzerland Banned banned United Kingdom Banned banned over period from 1964-1984 no production banned over period from 1972-1989 Republic of Macedonia Russia Slovak Republic Ukraine USA 12 European Community Luxemburg Romania 1 These responses are from three questionnaires sent to LRTAP Parties in 2000 and 2001 respectively. The responses from the 2000 questionnaire are on the web at: http://www.unece.org/env/documents/2000/eb/eb.air.2000.1.add.1.e.pdf 13 Attachment 3 The Stockholm Convention Information on Global DDT Production and Use On May 23, 2001, over 90 countries signed the Convention on Persistent Organic Pollutants at a diplomatic conference in Stockholm, Sweden. For the text of the Stockholm Convention, see http://www.chem.unep.ch/sc/documents/convtext/convtext_en.pdf The Stockholm Convention will require all Parties to eliminate or restrict the production, use and/or releases of specified POPs. All of the intentionally produced POPs except DDT are slated for elimination of production and use. In recognition of the humanitarian need to use DDT for disease vector control, the Convention allows its use for this purpose while encouraging the development of effective and economically viable alternatives. China, India, and the Russian Federation have submitted specific exemptions to produce DDT for public health purposes. Thirty-two countries have registered to use DDT for disease vector control, an acceptable purpose under the Convention. In addition, three countries (Brazil, China, and India) have requested a specific exemption to use DDT as an intermediate in the production of dicofol. For information, refer to http://www.chem.unep.ch/sc/documents/meetings/dipcon/25june2001/inf1rev3/k0122169.doc Country Stockholm Convention: Specific Exemption or Acceptable Purpose Algeria Use of DDT for vector control according to part II of Annex B Bangladesh Use of DDT for vector control Brazil Use of DDT in production of dicofol (contained in dicofol as a contaminant) Cameroon Use of DDT for disease vector control in accordance with part II of Annex B and in line with WHO guidelines China Production and use of DDT as an intermediate Production and use of DDT for disease vector control Comoros Use of DDT for disease vector control in accordance with part II of Annex B Costa Rica Use of DDT for disease vector control in accordance with part II of Annex B Côte d=Ivoire Use of DDT for disease vector control in accordance with part II of Annex B and in line with WHO guidelines Ecuador Use of DDT for disease vector control in accordance with part II of Annex B Eritrea Use of DDT for disease vector control/public health services in accordance with WHO guidelines Ethiopia Use of DDT for vector control for public health purposes in accordance with part II of Annex B India Production of DDT for use in vector control and as an intermediate in the production of dicofol. Use of DDT for vector control and in production of dicofol (contained in dicofol as a contaminant (maximum concentration 0.1%)) Islamic Republic of Iran Use of DDT for public health purposes in accordance with WHO guidelines Kenya Use of DDT in public health for vector control according to WHO guidelines Madagascar Use of DDT for vector control according to part II of Annex B ( expiration /review: 10 years) Malawi Use of DDT for malaria control Mauritius Use of DDT for disease vector control in accordance with part II of Annex B Morocco Use of DDT for vector control 14 Mozambique Use of DDT in the public health sector in accordance with WHO guidelines. Namibia Use of DDT for disease vector control Papua New Guinea Use of DDT for disease vector control in accordance with part II of Annex B Republic of Korea Use of DDT as a de minimis contaminant in dicofol (max. conc. 0.1%) Russian Federation Production of DDT for disease vector control in accordance with part II of Annex B Use of DDT for disease vector control in accordance with part II of Annex B Saudi Arabia Use of DDT for vector control for public health purposes in line with the WHO guidelines South Africa Use of DDT for disease vector control in accordance with part II of Annex B Sudan Use of DDT for vector control in public health in line with the WHO guidelines Swaziland Use of DDT in the public health sector for malaria control Togo Use of DDT for vector control in line with WHO guidelines Uganda Use of DDT for disease vector control/public health purposes in accordance with WHO guidelines United Republic of Tanzania Use of DDT for public health protection Venezuela Use of DDT for public health purposes in accordance with WHO guidelines Yemen Use of DDT for vector control in line with the WHO guidelines Zambia Use of DDT for disease vector control in accordance with part II of Annex B Zimbabwe Use of DDT for disease vector control in accordance with Part II of Annex B 15
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