EUROPEAN COMMISSION
Selection of chemical substances to be screened in the context of the impact
assessment on criteria to identify endocrine disruptors1
In July 2013 the Commission launched an impact assessment on criteria to identify
endocrine disruptors (EDs) in the context of the Plant Protection Products Regulation
(EC) No 1107/20092 and the Biocidal Products Regulation (EU) No 528/20123. Updated
information on the IA can be found on the dedicated website4.
To support the impact assessment, a specific contract was signed in April 2015 under
Framework Service Contract No SANCO/2012/02/011 with the aim of screening the
available evidence on chemicals used in plant protection and/or biocidal products, as well
as a selection of substances falling under the REACH Regulation 5 and the Cosmetic
Products Regulation6. Some of these selected substances are also priority substances
under the Water Framework Directive7. The identity (names and CAS-numbers) of the
substances included in this exercise are provided in this document. Some chemicals fall
within the scope of more than one legislative area and this is clearly indicated in the table
below. The final list of substances may be subject to minor changes.
The aim of the screening is to be able to estimate which chemicals would fall under the
different options for the criteria outlined in the roadmap8 of the impact assessment. This
exercise is part of the process of gathering information necessary for the impact
assessment. The screening is a desk-based work on the basis of existing evidence and
toxicological data, i.e. no additional data will be generated for the purpose of this work.
Consulting the regulatory agencies in the context of this work is not foreseen either.
The methodology that applies to the screening was developed by the Joint Research
Centre of the Commission (JRC). The screening methodology and the results of the
screening will be published once the screening is finalized.
The fact that substances are included in this screening exercise does not mean that
the substances should be considered - even on a "working hypothesis basis" - as
"endocrine disruptors" or "suspected endocrine disruptors". Rather, the rationale
for most of the substances being included in this screening exercise is the
availability of data, which is a pre-condition for this exercise.
As the screening is done in the context of an impact assessment, it does not
substitute evaluations of individual substances to be carried out under the
1 Updated list (format of CAS numbers corrected for some chemicals)
2
http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2009:309:0001:0050:EN:PDF
3
http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2012:167:0001:0123:EN:PDF
4
http://ec.europa.eu/health/endocrine_disruptors/impact_assessment/index_en.htm
5
http://ec.europa.eu/health/endocrine_disruptors/docs/reach_1907_2006_regulation_en.pdf
6
http://ec.europa.eu/health/endocrine_disruptors/docs/cosmetic_1223_2009_regulation_en.pdf
7
http://ec.europa.eu/health/endocrine_disruptors/docs/wfd_200060ec_directive_en.pdf
8
http://ec.europa.eu/health/endocrine_disruptors/impact_assessment/index_en.htm
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 1 of 23
respective chemical legislations. Therefore, the results of the screening exercise do
not pre-empt the regulatory conclusions that may eventually be drawn.
The selection of the chemicals for the impact assessment screening exercise was based on
the following general principles but differed between the legislative areas as described
lower down:
1. The selection process should be transparent and objective.
2. Availability of data is crucial for an assessment of endocrine properties.
Therefore priority is given to chemicals for which data are available.
3. The selection should not lead to a bias in the assessment of the four options.
1.
CHEMICAL SUBSTANCES REGULATED UNDER THE PLANT PROTECTION PRODUCTS
REGULATION (PPPR) AND THE BIOCIDAL PRODUCTS REGULATION (BPR)
All relevant chemicals approved by 11 May 2015 at European level to be used in
plant protection products and biocidal products were considered as a starting point.
The screening was then focused by excluding those substances that are considered
to be out of scope. The step-wise rationale followed for excluding active substances
from the screening is:
(1)
Microorganisms (living organisms, no chemical substances).
(2)
Basic substances, defined in Article 23 of Regulation (EC) No 1107/2009 as
being substances of no concern and no inherent capacity to cause endocrine
disrupting effects, and where the approval procedures follow particular rules.
(3)
Low risk substances, defined in Annex II to Regulation (EC) 1107/2009 as,
among others properties, not deemed to be an endocrine disruptor.
(4)
Natural extracts, mixtures, or repellents
(5)
Attractants (pheromones) or plant hormones
(6)
Others (e.g. inert substances, salts, acids)
324 substances falling under the PPPR and 95 substances falling under the BPR
were selected following this rationale. Among the 95 biocidal products group there
are also some chemicals not yet approved but where the corresponding opinions
were already adopted by the Biocidal Products Committee of the European
Chemical Agency (ECHA). 23 PPPs and 3 BPs were not selected following this
rationale but appear on the list because they were substances screened during the
earlier phase of the project.
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 2 of 23
2.
CHEMICAL SUBSTANCES REGULATED UNDER THE REACH REGULATION
Substances were selected for the screening exercise according to the following stepwise rationale:
(1)
All substances on the Candidate List already identified as Substances of
Very High Concern (SVHC) because of ED concerns under Art. 57(f)
(2)
All substances for which an SVHC opinion on the identification of the
substance as SVHC due to its endocrine disrupting properties was provided
by the Member State Committee at ECHA9;
(3)
All substances on the Candidate list identified as SVHC because of
reprotoxicity 1A/1B;
(4)
All substances listed in Annex XVII for restrictions due to an ED concern or
because of having a harmonised classification as reprotoxic 1A/1B;
(5)
All substances placed on the community rolling action plan (CoRAP) due to
ED concern;
149 REACH chemical substances were selected following this procedure. Further,
52 substances registered under REACH also appear on the list of screened
chemicals but were selected following the rationales applied for other legislative
frameworks (i.e. they are either PPPs/BPs or substances used in cosmetic products)
or because they were substances screened during the earlier phase of the project.
3.
CHEMICAL SUBSTANCES
REGULATION
REGULATED
UNDER
THE
COSMETIC
PRODUCTS
Substances used in cosmetic products were selected based on the following criteria:
(1)
Substances for which an opinion of the Scientific Committee on Consumer
Safety (SCCS) was provided, which contained a discussion but not
necessarily a conclusion on their endocrine disrupting potential;
(2)
Substances for which an SCCS opinion was provided due to the their
potential or de facto classification as carcinogenic, mutagenic, or toxic for
reproduction (CMR)1A/1B or CMR2 under the Classification, Labelling and
Packaging (CLP) Regulation;
(3)
Substances not classified as CMR but for which SCCS expressed some
concern on toxicity endpoints;
(4)
Substances for which concern was raised by stakeholders / Member States
on potential endocrine disrupting properties;
45 chemical substances falling under the Cosmetic products regulation were
selected following this procedure. A further 6 substances falling under the Cosmetic
products regulation also appear on the list of screened chemicals because they were
9
http://echa.europa.eu/role-of-the-member-state-committee-in-the-authorisation-process/svhc-opinions-of-the-member-state-committee
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 3 of 23
selected following the rationales applied for other legislative frameworks (i.e. they
are either PPPs /BPs or REACH substances.)
4.
CHEMICAL SUBSTANCES
DIRECTIVE (WFD)
REGULATED
UNDER
THE
WATER
FRAMEWORK
For the WFD, no specific selection criteria were applied to identify substances for
the screening. However, some of the substances on the screening list, selected
following the rationales applied for other legislative frameworks (i.e. PPPs/BPs,
Cosmetics or REACH), are listed individually or fall under a group (e.g. lead and its
compounds) in the list of priority substances under the WFD.
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 4 of 23
5.
10
CHEMICAL SUBSTANCES SCREENED IN THE CONTEXT OF THE IMPACT ASSESSMENT
10
ON CRITERIA TO IDENTIFY ENDOCRINE DISRUPTORS (IN ALPHABETICAL ORDER)
Chemical Name
CAS
[Phthalato(2-)]dioxotrilead
1,2,3-trichloropropane
1,2,4-trihydroxybenzene
1,2-benzenedicarboxylic acid,
di-C6-10-alkyl esters; 1,2benzenedicarboxylic acid,
mixed decyl and hexyl and
octyl diesters with ≥ 0.3% of
dihexyl phthalate (EC No. 201559-5)
1,2-Benzenedicarboxylic acid,
di-C6-8-branched alkyl esters,
C7-rich
1,2-Benzenedicarboxylic acid,
di-C7-11-branched and linear
alkyl esters
1,2-Benzenedicarboxylic acid,
dihexylester, branched and
linear
1,2-Benzenedicarboxylic acid,
dipentylester, branched and
linear
1,2-bis(2methoxyethoxy)ethane
(TEGDME,triglyme)
1,2-Diethoxyethane
1,2-Dihydroxy-benzene
1,2-dimethoxyethane,ethylene
glycol dimethyl ether (EGDME)
1,4-Dimethylnaphthalene
1-bromopropane (n-propyl
bromide)
1-Decanol
1-Methyl-2,6-diamino-benzene
1-Methyl-cyclopropene
1-Naphthylacetamide (1-NAD)
1-Naphthylacetic acid (1-NAA)
1R-trans phenothrin
2-(2-butoxyethoxy)ethyl 6-
69011-06-9
96-18-4
533-73-3
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1
1
1
68515-51-5
1
71888-89-6
1
68515-42-4
1
68515-50-4
1
84777-06-0
1
112-49-2
1
629-14-1
120-80-9
1
1*
1
110-71-4
571-58-4
1
1
106-94-5
112-30-1
823-40-5
3100-04-7
86-86-2
86-87-3
26046-85-5
51-03-6
Water
Framework
Directive
1*
1
1
1*
1
1
1
1
1
1
The cells with an * refer to substances which were not identified following a selection rationale for a specific legislative framework but are on the list
because they were selected following the rationales applied for other legislative frameworks or because they were substances screened during the
earlier phase of the project.
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 5 of 23
Chemical Name
propylpiperonyl ether
2-(2-methoxyethoxy)ethanol
2,2,6,6-tetrabromo-4,4isopropylidenediphenol
2,2',6,6'-Tetrabromo-4,4'isopropylidenediphenol,
oligomeric reaction products
with Propylene oxide and nbutyl glycidyl ether
2,2′,6,6′-Tetra-tert-butyl-4,4′methylenediphenol
2,2'-dimethyl-4,4'methylenebis(cyclohexylamine)
2,4-D
2,4-DB
2,4-di-tert-butylphenol
2,5-Dichlorobenzoic acid
methylester
2-Amino-3-hydroxypyridine
2-amino-4hydroxyethylaminoanisole
sulfate
2-ethoxyethanol
2-ethoxyethyl acetate
2-ethylhexyl 10-ethyl-4,4dioctyl-7-oxo-8-oxa-3,5-dithia4-stannatetradecanoate
(DOTE)
2-Ethylhexyl-4methoxycinnamate
2-Mercaptobenzothiazole
2-methoxyethanol
2-methoxyethyl acetate
2-Phenylphenol
3-amino-2,6-dimethylphenol
3-Benzylidene camphor
3-ethyl-2-methyl-2-(3methylbutyl)-1,3-oxazolidine
3-methylpyrazole
4-(1,1,3,3tetramethylbutyl)phenol
4-(1,1,3,3tetramethylbutyl)phenol,
ethoxylated
4,4'-isopropylidenediphenol
(Bisphenol-A)
CAS
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
111-77-3
1
1*
79-94-7
1
-
1
118-82-1
1
6864-37-5
1
94-75-7
94-82-6
96-76-4
1
1
2905-69-3
1
Water
Framework
Directive
1
16867-03-1
1
83763-48-8
1
110-80-5
111-15-9
1
1
15571-58-1
1
1
1
5466-77-3
1
1
149-30-4
109-86-4
110-49-6
90-43-7
6994-64-5
15087-24-8
143860-042
1453-58-3
1
1
1
1*
1
1
1
1*
1
1
1
1
140-66-9
1
-
1
80-05-7
1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 6 of 23
1*
Chemical Name
CAS
4,4'-sulfonyldiphenol
4,5-Dichloro-2-octylisothiazol3(2H)-one
4-hydroxybenzoic acid
4-Methylbenzylidene camphor
4-Nonylphenol, branched and
linear
4-Nonylphenol, branched and
linear, ethoxylated
4-tert-butylphenol
6,6'-di-tert-butyl-4,4'butylidenedi-m-cresol
6,6'-di-tert-butyl-4,4'-thiodi-mcresol
6-Benzyladenine
8-Hydroxyquinoline incl.
oxyquinoleine
Abamectin (aka avermectin)
Acequinocyl
Acetaldehyde
80-09-1
Acetamiprid
Acetic acid, lead salt, basic
Acibenzolar-S-methyl
(benzothiadiazole)
Aclonifen
Acrinathrin
Acrolein
Alkyl (C12-16) dimethylbenzyl
ammonium chloride; C 12-16ADBAC
alphachloralose
Alpha-Cypermethrin (aka
alphamethrin)
Aluminium phosphide
Aluminium sulphate
Ametoctradin
Amidosulfuron
Aminopyralid
Amisulbrom
Amitrole (aminotriazole)
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1
64359-81-5
Water
Framework
Directive
1
99-96-7
38102-62-4
1
1
-
1
1
-
1
98-54-4
1
85-60-9
1
96-69-5
1
1214-39-7
1
148-24-3
1
71751-41-2
57960-19-7
75-07-0
135410-207
51404-69-4
135158-542
74070-46-5
101007-061
107-02-8
1
1
1*
1*
1
1
1*
1
1
1*
1
1
1*
1
1
1*
68424-85-1
1
1*
15879-93-3
1
67375-30-8
1
1
20859-73-8
10043-01-3
865318-974
120923-377
150114-719
348635-870
61-82-5
1
1*
1
1*
1*
1
1
1
1
1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 7 of 23
Chemical Name
CAS
Ammonium dichromate
Ammonium
pentadecafluorooctanoate
(APFO)
ammonium perchlorate
Ammonium thiocyanate
Ascorbic acid
Azadirachtin
7789-09-5
Azimsulfuron
Azoxystrobin
Basic Copper carbonate:
inorganic
Beflubutamid
Benalaxyl
Benalaxyl-M
Bendiocarb
Benfluralin
Bensulfuron methyl
Bentazone
Benthiavalicarb
Benzo[a]pyrene
Benzoic acid
Benzophenone-3
Benzotriazole
Benzyl butyl phthalate (BBP)
Beta-Cyfluthrin
Bifenazate
Bifenox
Bifenthrin
Bis (2-ethylhexyl)phthalate
(DEHP)
Bis(2-ethylhexyl)
tetrabromophthalate
Bis(2-methoxyethyl) ether
Bis(2-methoxyethyl) phthalate
Bis(2-propylheptyl) phthalate
Bispyribac
Bixafen
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1
3825-26-1
1
7790-98-9
1762-95-4
50-81-7
11141-17-6
120162-552
131860-338
1
1
1*
1
1
1
12069-69-1
113614-087
71626-11-4
98243-83-5
22781-23-3
1861-40-1
83055-99-6
25057-89-0
413615-357
50-32-8
65-85-0
131-57-7
95-14-7
85-68-7
68359-37-5
149877-418
42576-02-3
82657-04-3
Water
Framework
Directive
1
1*
1
1
1
1
1
1
1
1
1
1
1*
1
1
1*
1
1
1
1*
1
1
1
1
1*
1
117-81-7
1
26040-51-7
1
111-96-6
117-82-8
53306-54-0
125401-925
581809-463
1
1
1
1
1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 8 of 23
1*
Chemical Name
Bordeaux mixture
Boric acid
Boric oxide: inorganic
Boscalid (formerly nicobifen)
Brodifacoum
Bromadiolone
Bromoacetic acid
Bromoxynil
Bromuconazole
Bupirimate
Buprofezin
C(M)IT/MIT
Cadmium chloride
Cadmium fluoride
Cadmium sulphate
Calcium phosphide
Camphor benzalkonium
methosulfate
Capric acid
Caprylic acid
Captan
Carbetamide
Carbon dioxide
Carbon disulphide
Carboxin
Carfentrazone-ethyl
Carvone
Chlorantraniliprole
chlorfenapyr
Chloridazon (aka pyrazone)
Chlormequat
Chloroacetamide
Chloromethane
Chlorophacinone
Chlorothalonil
Chlorotoluron
Chlorpropham
Chlorpyrifos
Chlorpyrifos-methyl
CAS
10043-35-3
1303-86-2
188425-856
56073-10-0
28772-56-7
79-08-3
1689-84-5
116255-482
41483-43-6
69327-76-0
55965-84-9
10108-64-2
7790-79-6
10124-36-4
1305-99-3
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1*
1
1
1
1
1
1
1
1
1
1
1*
1
1
1
1
1
1
1
1
1*
1*
1*
1*
52793-97-2
334-48-5
124-07-2
133-06-2
16118-49-3
124-38-9
75-15-0
5234-68-4
128639-021
99-49-0
500008-457
122453-730
1698-60-8
7003-89-6
79-07-2
74-87-3
3691-35-8
1897-45-6
15545-48-9
101-21-3
2921-88-2
5598-13-0
Water
Framework
Directive
1
1
1
1
1
1*
1
1
1*
1*
1
1
1
1
1
1
1
1
1
1*
1
1
1
1
1
1
1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
1*
Page 9 of 23
Chemical Name
CAS
Chlorsulfuron
64902-72-3
143807-663
27519-02-4
99129-21-2
114420-563
74115-24-5
81777-89-1
1702-17-6
210880-925
7646-79-9
513-79-1
71-48-7
10141-05-6
10124-43-3
1317-38-0
20427-59-2
14915-37-8
7758-99-8
5836-29-3
8001-58-9
312600-898
120116-883
101205-021
180409-603
400882-077
122008-859
57966-95-7
52315-07-8
94361-06-5
121552-612
66215-27-8
1596-84-5
80-08-0
533-74-4
3380-30-1
Chromafenozide
cis-tricos-9-ene (Muscalure)
Clethodim
Clodinafop
Clofentezine
Clomazone
Clopyralid
Clothianidin
Cobalt dichloride
Cobalt(II) carbonate
Cobalt(II) diacetate
Cobalt(II) dinitrate
Cobalt(II) sulphate
Copper (II) oxide
Copper hydroxide
Copper pyrithione
Copper sulphate pentahydrate
Coumatetralyl
Creosote
Cu-HDO
Cyazofamid
Cycloxydim
Cyflufenamid
Cyflumetofen
Cyhalofop-butyl
Cymoxanil
Cypermethrin
Cyproconazole
Cyprodinil
Cyromazine
Daminozide
Dapsone
Dazomet
DCPP
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1
Water
Framework
Directive
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1*
1*
1
1
1
1
1
1
1
1
1
1
1
1*
1
1
1
1
1
1
1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
1*
Page 10 of 23
Chemical Name
DDACarbonate
Decamethylcyclopentasiloxane
Deltamethrin
Denathonium benzoate
Desmedipham
Dibutyl phthalate (DBP)
Dibutyltin
Dibutyltin dichloride (DBTC)
Dicamba
dichlofluanid
Dichloromethane
Dichlorprop-P
Diclofop
Didecyldimethylammonium
chloride; DDAC
Diethofencarb
diethyl phthalate
Diethylene glycol monobutyl
ether
Difenacoum
Difenoconazole
Difethialone
Diflubenzuron
Diflufenican
Dihexyl phthalate
diisobutyl phthalate (DIBP)
Diisopentylphthalate
Dimethachlor
Dimethenamid-P
Dimethoate
Dimethomorph
Dimethyl glutarate
Dimoxystrobin
Dinoseb (6-sec-butyl-2,4dinitrophenol)
Dinotefuran
dioctyltin oxide
Dioxobis(stearato)trilead
CAS
894406-769
541-02-6
52918-63-5
3734-33-6
13684-56-5
84-74-2
683-18-1
1918-00-9
1085-98-9
75-09-2
15165-67-0
51338-27-3
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1
1
1
1*
1
1
1
1
1
1
1*
1*
1
1
1*
1
1
1*
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
88-85-7
165252-700
870-08-6
12578-12-0
1*
1
1
111-90-0
56073-07-5
119446-683
104653-341
35367-38-5
83164-33-4
84-75-3
84-69-5
605-50-5
50563-36-5
163515-148
60-51-5
110488-705
1119-40-0
149961-524
1*
1
1
1
7173-51-5
87130-20-9
84-66-2
Water
Framework
Directive
1
1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
1
1
Page 11 of 23
1*
Chemical Name
CAS
Dipentyl phthalate (DPP)
Diphenylether, octabromo
derivative C12H2Br8O
Diquat (dibromide)
Disodium octaborate
tetrahydrate
Disodium phosphonate
Disodium tetraborate
decahydrate
Disodium tetraborate
pentahydrate
Disodium tetraborate,
anhydrous
Disodium tetraborate:
inorganic or basic (food
additive)
Distillates (coal tar),
naphthalene oils,naphthalene
oil
Dithianon
Diuron
Di-μ-oxo-di-nbutylstanniohydroxyborane/
Dibutyltin hydrogen borate
C8H19BO3Sn (DBB)
Dodemorph
Dodine
131-18-0
Emamectin
Epoxiconazole
Esfenvalerate
Ethephon
Ethofumesate
Ethoprophos
Ethyl
butylacetylaminopropionate
Ethylene Glycol Monobutyl
Ether
Etofenprox
Etoxazole
Etridiazole
Eugenol
Famoxadone
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1
2764-72-9
1
1
12280-03-4
13708-85-5
1
1*
1303-96-4
1
12267-73-1
1
1
12179-04-3
1
1330-43-4
1
1*
84650-04-4
3347-22-6
330-54-1
1
1
1
1
75113-37-0
1593-77-7
112-65-2
155569-918
133855-988
66230-04-4
16672-87-0
26225-79-6
13194-48-4
1
1
1
1
1
1
1
1
1
52304-36-6
1
111-76-2
80844-07-1
153233-911
2593-15-9
97-53-0
131807-573
Water
Framework
Directive
1
1
1*
1
1
1
1*
1*
1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 12 of 23
1*
Chemical Name
CAS
Fatty acids, C16-18, lead salts
91031-62-8
161326-347
Fenamidone
Fenamiphos (aka
phenamiphos)
Fenazaquin
Fenbuconazole
Fenhexamid
Fenoxaprop-P
Fenoxycarb
Fenpropidin
Fenpropimorph
Fenpyrazamine
Fenpyroximate
Ferric phosphate
Fipronil
Flazasulfuron
Flocoumafen
Flonicamid (IKI-220)
Florasulam
Fluazifop-P
Fluazinam
Flubendiamide
Fludioxonil
Flufenacet (formerly
fluthiamide)
flufenoxuron
Flumioxazin
Fluometuron
Fluopicolide
Fluopyram
22224-92-6
120928-098
114369-436
126833-178
113158-400
72490-01-8
67306-00-7
67564-91-4
473798-593
134098-616
10045-86-0
120068-373
104040-780
90035-08-8
158062-670
145701-231
83066-88-0
79622-59-6
272451-657
131341-861
142459-583
101463-698
103361-097
2164-17-2
239110-157
658066-354
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1
Water
Framework
Directive
1*
1
1
1
1
1
1
1
1
1
1
1
1
1
1*
1
1*
1
1
1
1
1
1
1
1*
1
1
1
1
1
1
1
1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 13 of 23
Chemical Name
Fluoxastrobin
Flupyrsulfuron-methyl (DPX KE
459)
Fluquinconazole
Flurochloridone
Fluroxypyr
Flurtamone
Flutolanil
Flutriafol
Fluxapyroxad
Folpet
Foramsulfuron
Forchlorfenuron
Formamide
Formetanate
Fosetyl
Fosthiazate
Fuberidazole
Furfural
Gamma-cyhalothrin
Geraniol
Glufosinate
Glutaraldehyde
Glyphosate (incl trimesium aka
sulfosate)
Halosulfuron methyl
Haloxyfop-P (Haloxyfop-R)
Heptamaloxyloglucan
Hexaflumuron
Hexythiazox
Hydrochloric acid
hydrogen cyanide
Hydrogen peroxide
Hydroxyethyl-3,4methylenedioxyaniline HCl
Hydroxyethyl-pphenylenediamine sulfate
Hymexazol
Imazalil (aka enilconazole)
CAS
361377-299
144740-545
136426-545
61213-25-0
69377-81-7
96525-23-4
66332-96-5
76674-21-0
907204-313
133-07-3
173159-574
68157-60-8
75-12-7
22259-30-9
39148-24-8
98886-44-3
3878-19-1
98-01-1
76703-62-3
106-24-1
51276-47-2
111-30-8
1071-83-6
100784-201
95977-29-0
870721-816
86479-06-3
78587-05-0
7647-01-0
74-90-8
7722-84-1
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1*
1
1*
1*
1
1*
1
1
1
1
1
1
1
1
1
1*
1*
1*
94158-14-2
1
93841-25-9
1
10004-44-1
35554-44-0
Water
Framework
Directive
1
1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 14 of 23
Chemical Name
Imazamox
Imazaquin
Imazosulfuron
Imidacloprid
Imidazolidine-2-thione (2imidazoline-2-thiol)
Indolylbutyric acid
Indoxacarb
Indoxacarb (enantiomeric
reaction mass S:R 75:25)
Iodine
Iodosulfuron
IPBC
Ipconazole
Iprodione
Iprovalicarb
Isopentyl-p-Methoxycinnamate
Isoproturon
Isopyrazam
Isoxaben
Isoxaflutole
K-HDO
Kojic Acid
Kresoxim-methyl
lambda-Cyhalothrin
Laminarin
Lauric acid
Lead bis(tetrafluoroborate)
Lead chromate
Lead chromate molybdate
sulphate red (C.I. Pigment Red
104)
Lead cyanamidate
Lead di(acetate)
Lead diazide, Lead azide
Lead dinitrate
CAS
114311-329
81335-37-7
122548-338
138261-413
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1
1
1
1
1
96-45-7
133-32-4
144171-619
173584-446
7553-56-2
185119-760
55406-53-6
125225-287
36734-19-7
140923-177
71617-10-2
34123-59-6
881685-581
82558-50-7
141112-290
66603-10-9
501-30-4
143390-890
91465-08-6
9008-22-4
143-07-7
13814-96-5
7758-97-6
Water
Framework
Directive
1
1
1
1
1
1*
1
1
1*
1
1
1
1
1
1
1*
1
1
1
1
1
1
1
1
1*
1
1*
1*
1
1
1*
1*
12656-85-8
1
1*
20837-86-9
301-04-2
13424-46-9
10099-74-8
1
1
1
1
1*
1*
1*
1*
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 15 of 23
Chemical Name
CAS
Lead dipicrate
Lead hydrogen arsenate
Lead monoxide (lead oxide)
Lead oxide sulfate
Lead styphnate
Lead sulfochromate yellow (C.I.
Pigment Yellow 34)
Lead titanium trioxide
Lead titanium zirconium oxide
Lead(II) bis(methanesulfonate)
Lenacil
Limestone
Linuron
Low temperature tar oil,
alkaline,extract residues (coal),
low temperature coal tar
alkaline
6477-64-1
7784-40-9
1317-36-8
12036-76-9
15245-44-0
Lufenuron
Magnesium phosphide
Malathion
Maleic hydrazide
Mancozeb
Mandipropamid
Maneb
MBM
MCPA
MCPB
Mecoprop
Mecoprop-P
Medetomidine
Mepanipyrim
Mepiquat
Meptyldinocap
Mercury
Mesosulfuron
Mesotrione
Metaflumizone
Metalaxyl
Metalaxyl-M
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1
1
1
1
1
Water
Framework
Directive
1*
1*
1*
1*
1*
1344-37-2
1
1*
12060-00-3
12626-81-2
17570-76-2
2164-08-1
1317-65-3
330-55-2
1
1
1
1*
1*
1*
1
1*
1
122384-785
103055-078
12057-74-8
121-75-5
123-33-1
8018-01-7
374726-622
12427-38-2
5625-90-1
94-74-6
94-81-5
93-65-2
16484-77-8
86347-14-0
110235-477
15302-91-7
6119-92-2
7439-97-6
400852-666
104206-828
139968-493
57837-19-1
70630-17-0
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1*
1
1
1
1
1
1
1
1
1
1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 16 of 23
1*
Chemical Name
CAS
Metaldehyde
Metam (incl. -potassium and sodium)
Metamitron
Metazachlor
108-62-3
Metconazole
Methomyl
Methoxyacetic acid
Methoxyfenozide
Methyl 4-hydroxybenzoate
Methyl decanoate
Methyl nonyl ketone
Methyl octanoate
Metiram
Metobromuron
Metofluthrin
Metosulam
Metrafenone
Metribuzin
Metsulfuron-methyl
Milbemectin
MIT
Musk Ketone
Musk Xylene
Myclobutanil
N,N-diethyl-meta-toluamide
N,N-dimethylacetamide
N,N-dimethylformamide
Napropamide
Nicosulfuron
Nitrobenzene
Nitrogen
N-Methyl-2-pyrrolidone
N-methylacetamide
N-pentyl-isopentylphthalate
N-Phenyl-P-Phenylenediamine
n-Tetradecylacetate
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1
144-54-7
1
41394-05-2
67129-08-2
125116-236
16752-77-5
625-45-6
161050-584
99-76-3
110-42-9
112-12-9
111-11-5
9006-42-2
3060-89-7
240494-717
139528-851
220899-036
21087-64-9
74223-64-6
51596-10-2
2682-20-4
81-14-1
81-15-2
88671-89-0
134-62-3
127-19-5
68-12-2
15299-99-7
111991-094
98-95-3
7727-37-9
872-50-4
79-16-3
776297-699
101-54-2
1
1
Water
Framework
Directive
1
1
1
1
1
1*
1
1
1
1
1*
1*
1*
1
1
1
1
1
1
1
1*
1
1
1
1
1
1
1
1
1*
1
1
1
1
1
1
1*
1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 17 of 23
Chemical Name
CAS
o-Aminophenol
Octabenzone
Octamethyl cyclotetrasiloxane
Oligomerisation and alkylation
reaction products of 2phenylpropene and phenol
[Previously registered as
Phenol, methylstyrenated - EC
N. 270-966-8 and CAS N.
68512-30-1]
Orange lead (lead tetroxide)
Oryzalin
Oxadiazon
Oxamyl
95-55-6
1843-05-6
556-67-2
Oxasulfuron
Oxyfluorfen
p-(1,1-dimethylpropyl)phenol
Paclobutrazol
p-aminophenol
Parabens
Paraformaldehyde
p-cresol
Pelargonic acid
Penconazole
Pencycuron
Pendimethalin
Penflufen
Penoxsulam
Pentadecafluorooctanoic acid
(PFOA)
Pentalead tetraoxide sulphate
Penthiopyrad
Permethrin
Pethoxamid
Phenmedipham
phenol, styrenated,reaction
mass of 2,4,6-tris(1-phenylethyl)phenol and Bis(1phenylethyl) phenol
Phenolphthalein
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1
1*
1
1
1*
-
1314-41-6
19044-88-3
19666-30-9
23135-22-0
144651-069
42874-03-3
80-46-6
76738-62-0
123-30-8
30525-89-4
106-44-5
112-05-0
66246-88-6
66063-05-6
40487-42-1
494793-678
219714-962
Water
Framework
Directive
1
1
1*
1
1
1
1
1
1
1
1
1
1
1*
1
1
1
1*
1
1*
1
1
1
335-67-1
1
12065-90-6
183675-823
52645-53-1
106700-292
13684-63-4
1
1
1
1
1
61788-44-1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
1
1
Page 18 of 23
1*
Chemical Name
CAS
Phosmet
Picloram
732-11-6
1918-02-1
137641-055
117428-225
23103-98-2
29232-93-7
Picolinafen
Picoxystrobin
Pirimicarb
Pirimiphos-methyl
p-METHYLAMINOPHENOL
sulphate
Polyhexamethylene biguanide
hydrochloride
Polyvinylpyrrolidone iodine
Potassium dichromate
Potassium sorbate
p-phenylenediamine
Prochloraz
Profoxydim
Prohexadione
Propamocarb
Propan-2-ol
Propaquizafop
Propargite
Propiconazole
Propineb
Propoxycarbazone
propyl 4-hydroxybenzoate
Propyzamide
Proquinazid
Prosulfocarb
Prosulfuron
Prothioconazole
Pymetrozine
Pyraclostrobin
Pyraflufen-ethyl
Pyrethrins
Pyridaben
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1
1
1
1
1
1
1936-57-8
1
27083-27-8
1
25655-41-8
7778-50-9
24634-61-5
106-50-3
67747-09-5
139001-493
127277-536
24579-73-5
67-63-0
111479-051
2312-35-8
60207-90-1
12071-83-9
145026-819
94-13-3
23950-58-5
189278-124
52888-80-9
94125-34-5
178928-706
123312-890
175013-180
129630-199
121-21-1
96489-71-3
Water
Framework
Directive
1
1
1
1
1*
1*
1
1
1
1
1
1*
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 19 of 23
Chemical Name
Pyridalyl
Pyridate
Pyrimethanil
Pyriofenone
Pyriproxyfen
Pyrochlore, antimony lead
yellow
Pyroxsulam
Quaternium-15 (cis-isomer)
Quinmerac
Quinoclamine
Quinoxyfen
Quizalofop-P
Quizalofop-P-ethyl
Quizalofop-P-tefuryl
reaction mass of 1(1,2,3,4,5,6,7,8-octahydro2,3,8,8-tetramethyl-2naphthyl)ethan-1-one and 1(1,2,3,4,6,7,8,8a-octahydro2,3,8,8-tetramethyl-2naphthyl)ethan-1-one and 1(1,2,3,5,6,7,8,8a-octahydro2,3,8,8-tetramethyl-2naphthyl)ethan-1-one
reaction mass of 2-ethylhexyl
10-ethyl-4,4-dioctyl-7-oxo-8oxa-3,5-dithia-4stannatetradecanoate and 2ethylhexyl 10-ethyl-4-[[2-[(2ethylhexyl)oxy]-2oxoethyl]thio]-4-octyl-7-oxo-8oxa-3,5-dithia-4stannatetradecanoate
(reaction mass of DOTE and
MOTE)
Reaction product: bisphenol-A(epichlorhydrin),epoxy resin
(number average molecular
weight ≤ 700)
Repellents by smell of animal
or plant origin/ sheep fat
CAS
179101-816
55512-33-9
53112-28-0
688046-619
95737-68-1
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1
1
1
1
1
1
8012-00-8
422556-089
51229-78-8
90717-03-6
2797-51-5
124495-187
94051-08-8
100646-513
119738-066
1
1*
1
1
1
1
1
1*
1
1
1
-
1
-
1
25068-38-6
1
98999-15-6
Water
Framework
Directive
1*
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 20 of 23
Chemical Name
Repellents by smell of animal
or plant origin/ tall oil crude
Repellents by smell of animal
or plant origin/ tall oil pitch
Resorcinol
Rimsulfuron (aka renriduron)
CAS
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
8002-26-4
1*
8016-81-7
1*
108-46-3
122931-480
1*
Not
applicable
1*
Sedaxane
874967-676
1
Silthiofam
Sintofen (aka Cintofen)
S-Methoprene
S-Metolachlor
Sodium 5-nitroguaiacolate
Sodium chromate
Sodium dichromate
Sodium o-nitrophenolate
Sodium perborate,perboric
acid, sodium salt
sodium perchlorate
Sodium peroxometaborate
Sodium p-nitrophenolate
Spinetoram
Spinosad
Spirodiclofen
Spiromesifen
Spirotetramat
Spiroxamine
Sucrose
Sulcotrione
Sulfosulfuron
1
1
Sea-algae extract (formerly
sea-algae extract and
seaweeds)
Silicic acid (H2Si2O5), barium
salt (1:1), lead-doped,
Silicic acid, lead salt
Water
Framework
Directive
68784-75-8
1
11120-22-2
175217-206
130561-487
65733-16-6
178961-201
67233-85-6
7775-11-3
10588-01-9
824-39-5
1
1
1
1
1
1
1
1
1
-
1
7601-89-0
7632-04-4
824-78-2
187166-150
168316-958
148477-718
283594-901
203313-251
118134-308
57-50-1
99105-77-8
141776-321
1
1
1
1
1
1
1
1
1
1
1*
1
1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 21 of 23
1*
Chemical Name
Sulfurous acid, lead salt,
dibasic
Sulfuryl fluoride
Tar acids, coal, crude,crude
phenols
tau-Fluvalinate
Tebuconazole
Tebufenozide
Tebufenpyrad
Teflubenzuron
Tefluthrin
Tembotrione
Tepraloxydim
Terbuthylazine
Tert-butyl methyl ether
tert-butyl-4-methoxyphenol
Tetraconazole
Tetraethyllead
Tetralead trioxide sulphate
Thiabendazole
Thiacloprid
Thiamethoxam
Thiencarbazone
Thifensulfuron-methyl
Thiophanate-methyl
Thiram
Thymol
Tolclofos-methyl
toluene-2,5-diamine sulfate
tolylfluanid
Tralkoxydim
Tralopyril
Transfluthrin
Triadimenol
CAS
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
62229-08-7
2699-79-8
1
1
1*
1
65996-85-2
102851-069
107534-963
112410-238
119168-773
83121-18-0
79538-32-2
335104-842
149979-419
5915-41-3
1634-04-4
25013-16-5
112281-773
78-00-2
12202-17-4
148-79-8
111988-499
153719-234
317815-831
79277-27-3
23564-05-8
137-26-8
89-83-8
57018-04-9
615-50-9
731-27-1
87820-88-0
122454-299
118712-893
55219-65-3
Water
Framework
Directive
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1*
1
1
1*
1
1*
1
1
1
1
1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 22 of 23
1*
1*
Chemical Name
CAS
Tri-allate
Triasulfuron
Triazoxide
Tribasic copper sulfate
Tribenuron (aka
metometuron)
Tributyltin compounds
Triclopyr
Triclosan
2303-17-5
82097-50-5
72459-58-6
1333-22-8
106040-486
55335-06-3
3380-34-5
141517-217
68694-11-1
64628-44-0
135990-293
Trifloxystrobin
Triflumizole
Triflumuron
Triflusulfuron
Trilead bis(carbonate)
dihydroxide
Trilead diarsenate
Trilead dioxide phosphonate
Trimethylamine hydrochloride
Trinexapac (aka cimetacarb
ethyl)
Triphenyl phosphate
Triphenyl phosphite
Triphenyltin
Tris(2-chloroethyl)phosphate
Triticonazole
Tritosulfuron
Trixylyl phosphate
Urea
Valifenalate (formerly
Valiphenal)
Warfarin
Warfarin sodium
zeta-Cypermethrin
Zinc phosphide
Zineb
Ziram
Zoxamide
Plant
Biocidal
Protection
Cosmetics REACH
Products
Products
1
1
1
1*
Water
Framework
Directive
1
1
1*
1
1*
1
1
1
1
1
1
1319-46-6
1
1*
3687-31-8
12141-20-7
593-81-7
143294-897
115-86-6
101-02-0
115-96-8
131983-727
142469-145
25155-23-1
57-13-6
283159-900
81-81-2
129-06-6
131550118-8
1314-84-7
12122-67-7
137-30-4
156052-685
1
1
1*
1*
1*
1
1
1
1
1
1
1
1
1
1*
1*
1
1
1
1*
1
1*
1
1
1
1
Selection of chemical substances to be screened in the context of the IA on criteria to identify ED
Page 23 of 23