365
Days of Innovation
ST VINCENT’S RESEARCH REPORT 2012
Contents
01
ABORIGINAL HEALTH
101
INTENSIVE CARE UNIT
03
ADDICTION MEDICINE
105
INFECTIOUS DISEASES
06
AGED MENTAL HEALTH
106
MEDICAL IMAGING
21
ALLIED HEALTH
110
MENTAL HEALTH
21NUTRITION
23 OCCUPATIONAL THERAPY
121
NEPHROLOGY
25Physiotherapy
124
NEUROSCIENCES
28PROSTHETICS
ANDВ ORTHOTICS
134
O’BRIEN INSTITUTE
29SOCIAL WORK
141
ONCOLOGY
33
ANAESTHETICS
149
ORTHOPAEDICS
37
BREASTSCREEN
157Podiatry
39
CARDIOTHORACICS
158
REHABILITATION
160
RESPIRATORY MEDICINE
RESEARCH CENTRE
62
163
RHEUMATOLOGY
CENTRE FOR NURSING RESEARCH
67
167
UNIVERSITY OF MELBOURNE
CENTRE FOR PALLIATIVE CARE
72
DERMATOLOGY
44
CARDIOVASCULAR
78
EMERGENCY PRACTICE
INNOVATION CENTRE
83
ENDOCRINOLOGY AND DIABETES
86
GASTROENTEROLOGY
91
HAEMATOLOGY
97
IMMUNOLOGY
DEPARTMENT OF MEDICINE
189
NIVERSITY OF MELBOURNE
U
DEPARTMENT OF SURGERY
202
VICTORIAN CANCER
CYTOGENETICS SERVICE
Aboriginal Health
Mission
The St Vincent’s Mission Department has
Aboriginal health as one of its areas of
responsibility. The focus of research in
AboriginalВ health is on improving care for
Aboriginal patients and their families through
improved culturally sensitive practice and
improved systems and processes utilising
aВ continuous quality improvement approach.
ABOUT US
The focus of research in Aboriginal health is to
improve the hospital’s response to the needs
ofВ Aboriginal patients and their families. The areas
of focus have been highlighted by the Aboriginal
community along with other key health organisations.
For 2012 these areas included concluding work in
mental health and cardiac care as well continuous
quality improvement projects that address culturally
sensitive care issues for Aboriginal people. Our
approach is to work in partnership with our
AboriginalВ staff, Aboriginal organisations and
researchВ organisations to ensure they are part
ofВ anyВ project development and implementation.
Our work has been influenced by the Improving
Culture of Hospitals Project (ICHP) that was funded
by the Lowitja Institute and completed by Latrobe
University in 2010. The resulting quality improvement
framework and toolkit entitled the �Aboriginal and
Torres Strait Islander Patient Quality Improvement
Toolkit for Hospital Staff” (AQITHS) is hosted on the
St Vincent’s internet page at http://www.svhm.org.
au/aboutus/community/ICHPtoolkit/Pages/toolkit.
aspx.
MAJOR PROJECTS
St Vincent’s was successful in being awarded a
tender from the Centre for Aboriginal Health, NSW
Health to implement an Aboriginal Continuous
Quality Improvement (CQI) Framework in eight
NSW hospitals in early 2012. The Aboriginal
Identification in Hospitals Quality Improvement
Project plans to improve the cultural competency
of staff, increase the number of Aboriginal people
identified as such in hospital’s routinely collected
data, reduce the proportion of Aboriginal patients
who had an Incomplete Emergency Attendance (IEA)
presentation, reduce the proportion of Aboriginal
patients who are admitted to hospital but Discharge
Against Medical Advice (DAMA) in Emergency
Departments and improve hospitals capacity to
meet the National Safety and Quality Health Service
Standards (NSQHSS) in relation to Aboriginal health.
This project will conclude in June 2014.
St Vincent’s received Closing the Gap funding
from the Victorian Department of Health to work
with Northern Health and Western Health on the
implementation of the AQITHS. This project
involves both Aboriginal and non-Aboriginal
researchers working with Western and Northern
hospital staff to develop and implement quality
improvement projects in partnership with their
localВ Aboriginal organisations.
The Aboriginal Mental Health Liaison Officer
Trial project, made possible by funding from
St Vincent’s Private Hospital, commenced in 2011
and was completed in 2012. It involved trialling and
evaluating the effectiveness of the role from both
staff (St Vincent’s and Victorian Aboriginal Health
Service) and patient perspectives.
The St Vincent’s Aboriginal Health team in partnership
with Victorian Aboriginal Health Service and the
St Vincent’s Centre for Nursing Research completed
a project to improve the service response to
Aboriginal patients by the cardiology department
and also increase the access to cardiac rehabilitation.
st vincent’s research report 2012
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Aboriginal HealtH
STAFF
John Willis,
Coordinator Aboriginal Health Projects 0.6EFT
Michelle Winters,
Senior Aboriginal Liaison Officer 0.2EFT
Sonia Posenelli,
Research Consultant 0.4EFT
Mandy Punch,
AHLO/Research Assistant (until Oct 2012) 0.4EFT
GRANTS
Chong A (Principle Investigator), Willis J,
ClarkeВ A, Wilson G, Winters M, Posenelli S,
Donahue K, Associate Investigators: Stewart J,
Shakeshaft A, Gilmour S
Aboriginal Identification in Hospitals Quality
Improvement Project, Centre for Aboriginal Health,
NSW Health
$636,493 for 2011–2014 ($120,000 in 2012)
Willis J (Principle Investigator), Love M,
BosanacВ P, Shanahan N, Swiatowy M
Aboriginal Mental Health Liaison Officer Trail Project,
St Vincent’s Research Endowment Fund
$9,401 for 2011–2012 ($1,901 in 2012)
Willis J (Principle Investigator), Posenelli S,
Clarke A, Winters M, Andrews S, Vassos S
Improving the Pathways to Hospital Care, North
West Region Victorian Department of Health –
Closing the Gap Project
$120,000 for 2011–2012 ($90,000 in 2012)
COLLABORATIONS IN RESEARCH
National
• Lowitja Institute, Carlton, Victoria
• Onemda VicHealth Koori Health Unit,
UniversityВ ofВ Melbourne, Carlton, Victoria
st vincent’s research report 2012
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Addiction Medicine
St Vincent’s Department of Addiction Medicine
maintains an active research program with
the main emphasis on translating current and
emerging knowledge about basic brain function
and neuroscience directly into new and more
effective treatments for drug and alcohol
addiction.
ABOUT US
The Department of Addiction Medicine at
St Vincent’s is one of Australia’s leading centres
forВ the medical treatment of drug or alcohol
addiction. Our multidisciplinary research team
isВ clinically based, and includes doctors, nurses
andВ specialist counsellors. Our focus is to translate
current and emerging knowledge about basic brain
function and neuroscience directly into new and
more effective medical treatments for addiction,
andВ to ensure that these are rapidly available
toВ asВ many people as possible. The patients
andВ their families we engage with are from a wide
rangeВ of backgrounds, including those whose
lives are extremely disadvantaged. The emphasis
of our research includes novel medical treatment
programs for a range of drug and behavioural
dependencies that include alcohol, amphetamines,
benzodiazepines, cannabis, gambling, opiates,
opioid substitution treatment (OST) and tobacco.
We strive to ensure that our clinical knowledge,
experience and research findings inform public
health policy, to achieve a more sophisticated
understanding in the community of the nature
andВ treatment of addiction, and to improve the
health outcomes for those seeking assistance
forВ drug or alcohol problems.
Major projects
�Brain Stories’: A unique, science-based drug
and alcohol education and training program for
Indigenous health workers
The �Brain Stories’ project is an innovative sciencebased Drug and Alcohol education and training
program for indigenous health workers and
those working with the indigenous community.
It incorporates unique educational �flipcharts’
usingВ plain language and culturally relevant images
to explain complex information about alcohol and
drug abuse, their effects on the brain and behaviour,
and how to best reduce or eliminate their harmful
effects caused to indigenous communities. The
aim of the �Brain Stories’ program is to enable
individuals, families, communities and health
professionals to increase understanding about
whyВ itВ is important to seek and persist with treatment
for alcohol and drug problems. This knowledge
can greatly improve the chance of benefitting from
modern medical health care.
A pilot study of subcutaneous flumazenilВ infusion
in the management of benzodiazepine withdrawal
This study has examined a new pharmacological
treatment for the management of long-term
benzodiazepine dependence, which has frequently
proven resistant to conventional treatment.
TheВ subcutaneous flumazenil infusion technique
is less invasive and requires fewer staff resources
compared with intravenous administration
suggesting a significant advantage in the
management of benzodiazepine withdrawal.
Treatment of alcohol dependent patients at-risk
for Wernicke-Korsakoff-related brain damage
Wernicke-Korsakoff syndrome (WKS) is
aВ neurological disorder caused by thiamine
deficiencyВ associated with alcohol dependence
orВ other causes of malnutrition. Although WKS
is aВ common condition, there are currently no
universally accepted, national or international,
evidence based guidelines for thiamine dosing
forВ the treatment of either acute symptomatic
WKSВ or for prevention of subclinical WKS related
brain damage in at-risk people. This study is aimed
at evaluating the effectiveness of high and low
thiamine doses in at-risk alcohol dependent patients.
QUALITY
2012: The �Brain Stories’ study has demonstrated
the effectiveness of using flipcharts with plain
language and informative culturally relevant images
as an educational tool to deliver complex scientific
information about substances and their effects on
the brain and behaviour for indigenous communities.
Our study indicated an improved knowledge
about the impact substances have on the brain
when making decisions. In particular, Brain Stories
education sessions confer a greater understanding
of the relationship between the brain and substance
use. This unique educational tool will continue
toВ empower individuals, families, communities
andВ health professionals in the area of alcohol
andВ drug treatment.
st vincent’s research report 2012
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Addiction Medicine
STAFF
SERVICE TO THE WIDER COMMUNITY
Prof Jon Currie, Director of Addiction Medicine
Professor Jon Currie
A/Prof Yvonne Bonomo,
Consultant Addiction Medicine Physician
• Australian National Council on Drugs (ANCD)
– the principal advisory body to the Prime
MinisterВ and the Federal Government on drug
andВ alcohol policy.
Dr Martyn Lloyd-Jones,
Consultant Addiction Medicine Physician
Dr Lisa Collins, Senior Project Manager
• National Health and Medical Research Council
(NHMRC), Consumer Participation Statement
Working Group
Dr Ruxsana Shafiq-Antonacci,
Senior Project Manager
• NHMRC, Dementia Collaborative Research
Centres (DCRC) Chair
Dr Joy Sha, Medical Registrar
Dr Taz Dissanayake,
Emergency Department Registrar
• St Vincent’s Health Australia, National Steering
Committee on Aboriginal and Torres Strait Islander
Peoples’ Health and Well Being
Eve Dimopoulos,
Administrative Assistant (clinical data)
• Anex, International Overdose Awareness Day
Australia Committee member
Jade Cruse, Executive Assistant to Prof Jon Currie
(clinical data)
• Department of Health, Withdrawal Advisory Group
Helen O’Neill, Clinical Research Nurse
Denny Cruse, Executive Assistant to Prof Jon Currie
(clinical data)
Students
Jan Fletcher, Honours student
Theses passed in 2012
Jan Fletcher, Honours, Monash University
• First Step Program – Board Member and Medical
Advisor
• Mental Health Research Institute –
ProfessorialВ Research Fellow
Associate Professor Yvonne Bonomo
• Representative for Addiction Medicine,
EditorialВ Board, Internal Medicine Journal
Doctor Martyn Lloyd-Jones
• Chair of the Victorian & Tasmanian Branch of
theВ Australasian Chapter of Addiction Medicine
atВ the Royal Australasian College of Physicians
• Deputy Chair Delmont Private Hospital
• Medical director Drug and Alcohol program
atВ Delmont Private Hospital
• Chair VAILA (Victorian Addiction Medicine
Inter-hospital Liaison Association)
st vincent’s research report 2012
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Addiction Medicine
GRANTS
Speaking engagements
Currie J, Cairney S
Brain Stories’: A unique, science based drug
and alcohol education and training program for
Indigenous health workers, Proceeds of Crime Act
(POAC)
$154,000 for 2011–2012 ($49,344 in 2012)
Professor Jon Currie:
COLLABORATIONS IN RESEARCH
Dr M Lloyd-Jones:
• The Peter MacCallum Cancer Centre, East
Melbourne, Victoria
• Northern Territory Department of Health Alcohol
and Drug Program
• MIMI Arts and Crafts Katherine, NT
• Mission Australia Katherine Office, NT
• Northern Territory Department of Health Alcohol
and Drug Service
• Aboriginal Health Wurli Wurlinijang, NT
• Catholic Care Northern Territory Katherine office,
NT.
• Ngwala Willumbong, a Victorian Statewide
Aboriginal Alcohol and Drug Service
• Portland Hospital Alcohol and Drug Service
PUBLICATIONS
Journal articles
Brief report:
Pastor A, Lloyd-Jones M, Currie J. (April 2012).
High-dose Baclofen for treatment-resistant
alcohol dependence. Journal of Clinical
Psychopharmacology. 32(2): 266–8.
Editorial:
Lloyd-Jones M. (Dec 2012). Is there a role for
coercive treatment in the management of addiction
in Australia? Internal Medicine Journal. 42(12):
1285–7.
�Severe Substance Dependence Treatment Act’,
St Vincent’s Melbourne Grand Rounds, July 2012
�Alcohol – some updates’, Alice Springs Hospital
Grand Rounds, Northern Territory, July 2012
�Addiction Medicine response’, S8 Opioid Forum,
Department of Health, College of Anaesthetists,
Melbourne, November 2012
�Consultation liaison drug and alcohol issues in
hospital practice’, Australasian Professional Society
on Alcohol and other Drugs (APSAD), Melbourne,
November 2012
�Talking about addiction – the management of
alcohol and drug problems in psychiatric practice’,
Delmont Private Hospital, Melbourne, November
2012
�The Severe Substance Dependence Treatment Act
and our experience over the last 12 months’, Turning
Point Talking Point, Melbourne, July 2012
�Sleep disorders’, Northern Division of General
Practice, Melbourne, May 2012
�Drug and alcohol issues in the elderly’,
StВ GeorgesВ Hospital, Melbourne, February 2012
�What is addiction?’, Community lecture for Drug
Action Week, Geelong, June 2012
�Post traumatic stress disorder and substance use
disorders’, Barwon Health, Geelong July 2012
Sharyn Amos:
�Brain Stories Program: translating cutting edge
addiction brain science directly into practical
addiction medicine education and treatment
programs for Aboriginal and Torres Strait Islander
communities’, National Indigenous Drug and Alcohol
Committee conference, Fremantle, WA, June 2012
st vincent’s research report 2012
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Aged Mental Health Service
St Vincent’s Aged Mental Health Service
(SVAMHS) integrates comprehensive, seamless,
multidisciplinary service delivery with research.
About us
The main research active groups within SVAMHS
are the Academic Unit for Psychiatry of Old Age
(AUPOA), The Dementia Behaviour Management
Advisory Service Vic (DBMAS) and the inpatient
ward Normanby Unit. The Academic Unit for
Psychiatry of Old Age (AUPOA) is part of the
Department of Psychiatry at the University of
Melbourne. Both AUPOA and DBMAS, although
receiving external funding, are integrated in
SVAMHS. The AUPOA operates at Normanby House
five specialist outpatient clinics. These clinics provide
assessment, clinical diagnosis and management,
support to patients, their families and health service
providers. In four of the five clinics patients have the
option to participate in research projects. Currently
active research areas of the SVAMHS are community
engagement, innovative service development and
quality improvement, education on mental health
issues in old age, health promotion, cognitive
impairment and dementia, Alzheimer’s Disease and
Huntington’s Disease.
Major projects
The Pastoral Care in Aged Mental Health Project
is a collaborative project between the Academic
Unit for Psychiatry of Old Age, The University of
Melbourne (AUPOA), the St Vincent’s Aged Mental
Health Service (SVAMHS), the Pastoral Services
Department at St Vincent’s Hospital Melbourne
and Healthcare Chaplaincy Council of Victoria
(HCCVI), the peak body for pastoral care in health in
Victoria. Two papers resulting from this project were
presented at the World Congress of the International
Psychogeriatric Association in Cairns, Australia in
2012 and at the National Conference of the Centre
for Ageing and pastoral studies in Canberra.В An
article, �Pastoral Care in Old Age Psychiatry:
Addressing the spiritual needs of inpatients in an
acute aged,mental health unit’ (Goh A, Eagleton
T, Kelleher R, Yastrubetskaya O, Taylor M, Chiu E
and Lautenschlager NT)В has been accepted by the
professional journal Asia Pacific Psychiatry. The
publication, A Voice at the Table: An integrated
model for pastoral care in aged mental health has
been widely distributed and very well received within
aged mental health and pastoral care services in
Australia and overseas. It is now required reading
in the pastoralВ counselling unit at Melbourne
Theological College. The model has been presented
by the project co-ordinator at continuing education
programs for pastoral care practitioners in health
settings in Victoria. A quality assurance activity is
now planned to study the models of pastoral care
provision in all Victorian aged mental health services.
Conference presentations and a journal article are
planned. This will enable further improvement in
the pastoral care provision within St Vincent’s Aged
Mental Health Service Melbourne and the wider
service system and community.
st vincent’s research report 2012
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Aged Mental Health Service
Staff
Students
Prof Nicola Lautenschlager, Professor
UniВ Melbourne, Head of AUPOA & Director,
SVAMHS 1.0EFT
Dr Samantha Loi (PhD student)
Prof David Ames, Sessional Consultant Psychiatrist
0.1EFT (AUPOA)
Nicola Lautenschlager, David Ames and Ed Chiu
give regular presentations, education to community
members.
Prof Edmond Chiu, Honorary Consultant Psychiatrist
& Professorial Fellow (AUPOA)
Dr Anita Goh, Research Fellow 0.6EFT (AUPOA)
Dr Samantha Loi, Lecturer, 0.4EFT (AUPOA)
Dr Kathryn Anne Ellis, Research Fellow 1.0EFT
(AUPOA)
Rosemary Kelleher, Senior Social Worker Honorary
Fellow AUPOA & Pastoral Care Department
Alissa Westphal, Lecturer, BPSD Management
0.2EFT (AUPOA)
Robyn Attoe, Lecturer, Dementia Care,
CasualВ (AUPOA)
Dr Ian Thompson, Speech Pathologist,
HonoraryВ Fellow (SVAMHS & AUPOA)
Dr Vahid Payman, Consultant Psychiatrist,
HonoraryВ Fellow (SVAMHS & AUPOA)
Dr Tanya Clifton, Consultant Psychiatrist,
HonoraryВ Fellow (AUPOA)
Dr Patrick O’Brien, Consultant Psychiatrist,
HonoraryВ Fellow (AUPOA)
Dr Andrew Churchyard, Neurologist,
HonoraryВ Fellow (AUPOA)
Dr Phyllis Chua, Consultant Psychiatrist,
HonoraryВ Fellow (AUPOA)
Stephanie Antonopoulos, Research Assistant
0.6EFT (AUPOA)
Joy Preston, Administrative Assistant 1.0EFT
(AUPOA)
Marilyn Manison, Administrative Assistant 0.3EFT
(AUPOA)
Bernadette Parker, Administrative Assistant
(untilВ August 2012) 1.0 EFT (AUPOA)
SERVICE TO THE WIDER COMMUNITY
Nicola Lautenschlager
• Editor-in-Chief, International Psychogeriatrics
• Co-organiser with Prof Edmond Chiu of the 17th
University of Melbourne Symposium on Psychiatry
of Old Age, L’Unica Convention Centre 2011
• Reviewer for journals.
• Member of the Rehabilitation, Aged Care,
PalliativeВ Care & Psychiatry of Old Age (RAPP)
Board of Studies Committee, Faculty of Medicine,
University of Melbourne.
• Reviewer for grants: NHMRC grants and
fellowships, Alzheimer Research Trust grant,
UK, American Alzheimer’s Association, Pfizer
Neuroscience research grants, Alzheimer Australia
Research Dementia grants, MD and PhD theses
David Ames
• Member, Board of Directors, International
Psychogeriatric Association
• International Journal of Geriatric Psychiatry
Editorial Board member
• Member Editorial Board, International Journal
ofВ Psychiatry in Clinical Practice
• Member, Medical and Scientific Advisory Panel,
Alzheimer’s Disease International
• Chief Medical Advisor to Alzheimer’s Australia
• International Psychiatry Reviews
EditorialВ BoardВ member
• Member of annual interviewing panel for selection
of graduate entrants to University of Melbourne
Faculty of Medicine
Jane Bartley, Administrative Assistant,
(sinceВ AugustВ 2012) 0.8 EFT (AUPOA)
st vincent’s research report 2012
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Aged Mental Health Service
Rosemary Kelleher
• October 2012 Ongoing: Co-convenor. Symposium
on Ageing Society: Prediction and Preparation at
IPA International Congress Seoul, South Korea
October 2013
• Associate Editor (Social Work) International
Psychogeriatric Association Bulletin
• 2012 0ngoing: Member, Aged Care Advisory
Committee, Healthcare Chaplaincy Council
ofВ Victoria Inc.
Kathryn Ellis
• Organising committee for a national forum
(National Dementia Forum, Canberra 2012)
• Organising committee, Annual consumer event
held for volunteers participating in the AIBL study
• Contributor for the Alzheimer’s Association Vic.
Staff Professional Development Program 2012
Samantha Loi
• Ongoing volunteer work with asylum seekers at
the Asylum Seeker Resource Centre
• Associate member of Huntington’s Victoria
Research Group
Anita Goh
• Deputy Director of University of Melbourne
Department of Psychiatry Research
subcommittee. May 2012, St Vincent’s Health
Australia Quality Awards – Finalist Category:
Mission and Social Justice – Mary Aikenhead
Award, Pastoral Care inВ Aged Mental Health
• Co-chair of organising committee for University
of Melbourne Department of Psychiatry Research
Symposium 26 August 2012. This symposium
consisted of invited presentations by the head of
each centre of the department, panel discussions,
poster sessions, and awards
APATT
• Collaborating with Ethnic Communities’ Council
of Victoria to facilitate a one day aged care
forum as part of cultural diversity week: �An ABC
of Mental Health Care – Demystifying mental
health care for older people from non-English
speaking backgrounds’. This was a professional
development forum for the ethnic aged care
sector to enhance awareness of mental health
issues and services with ethnic and multicultural
aged care agencies, local and state governments,
community based mental health service providers
and other stakeholders with an interest in mental
health in relation to community aged care for
people from non-English speaking backgrounds.
DBMAS
• DBMAS Vic is a statewide service, operating
throughout metropolitan and regional Victoria.
Informal (or family/home based) carers as well
as health professionals and paid carers from
residential and community care settings can
access the DBMAS service. A pilot program
providing phone and web-based DBMAS
Old AgeВ Psychiatry case consultations, case
discussion sessions and education to key staff
supporting people with dementia in regional
Victoria and remote areas of the Northern Territory
will be completed in June 2013. The project was
evaluated by NARI and the final evaluation report
will be submitted to DOHA in 2013.
GRANTS
D Ames, E Chiu, NT Lautenschlager, O
Yastrubetskaya, P O’Brien, P Chua, C Fonseka,
AВ Goh, B Mannaa
Randomised, double-blind, parallel-group, placebocontrolled, fixed dose study of Lu AE58054 in
patients with moderate Alzheimer’s disease treated
with donepezil, Lundbeck
$20,000 for 2009–2012 ($12,000 in 2012)
D Ames
Concert: a phase III multicentre, randomised,
placebo-controlled, double blind placebo controlled,
12 month safety and efficacy study evaluating
dimebon in patients with mild to moderate
Alzheimer’s disease on donepezil, Novotech
$120,000 for 2009–2012 ($30,000 in 2012)
D Ames, N Lautenschlager, K Ellis
The Australian Imaging Biomarkers and Lifestyle
(AIBL) Study, CSIRO & Pfizer
$3.7 million for 2012–2014 (ongoing)
NT Lautenschlager, P Desmond, K Cox, D Ames,
C Szoeke, O Salvado, M Sharman, K Ellis, P Phal
A randomised clinical trial of physical activity to delay
the progression of cerebrovascular disease in older
adults with memory complaints and mild cognitive
impairment, NHMRC
$632,152.80 for 2011–2013 ($148,735 (via NARI)
inВ 2012)
st vincent’s research report 2012
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Aged Mental Health Service
A Westphal, D LoGiudice, A Lamb,
NTВ Lautenschlager
The Wilfrid Gordon McDonald Partridge
Reminiscence Project, Department of Health
andВ Ageing
$50,000 over 2 years ($50,000 in 2012)
D Ames, NT Lautenschlager, K Hill, B Dow,
EВ Cyarto, M Russell, K Moore
A Randomised Controlled Trial to improve
depression in family carer through a physical
activityВ intervention, NHMRC
$697,797 for 2012–2015 ($163,670 in 2012)
A Goh, NT Lautenschlager, K Cox, A Hannan
Fit-HD, Bequest from HD family
$15,000 in 2012
A Goh and D Ames, NT Lautenschlager,
SВ Antonopoulos, S Loi, J Preston
REACH2HD, Prana Biotechnology
$117,000 for 2012–2013 ($60,000 in 2012)
A Goh, NT Lautenschlager, E Chiu, R Reilmann,
O Yastrubetskaya
Quantitative motor assessment in patients
with mild to moderate Alzheimer’s disease,
St Vincent’s Research Endowment Fund
$15,000 for 2011–2012 ($15,000 in 2012)
A Goh, E Chiu, Associate O Yastrubetskaya,
BВ Mannaa
Horizon Extension Study – A Phase 3, Randomized,
Double-Blind, Placebo-Controlled Safety and
Efficacy Study of Dimebon in Patients with
mild-to-moderate Huntington Disease (HD)
(ProtocolВ No.В DIM20), Huntington Study Group
$3,426 in 2012
A Westphal, NT Lautenschlager, D LoGiudice,
AВ Lamb
My Story, My Life Reminiscence Project,
DepartmentВ of Health and Ageing
$54,947.55 ($43,814.66 in 2012)
J Paulsen. S Goh (site investigator)
Neurobiological Predictors of Huntington’s Disease
(PREDICT–HD), National Institutes of Health, USA;
CHDI Foundation
Per participant basis for 2007–present ($160,000
inВ 2012)
S Loi, NT Lautenschlager
Improving dementia literacy and empowering carers,
Dementia Training Study Centre
$5,000 in 2012
W Hall, A Westphal, NT Lautenschalger,
AВ Goh,В SВ Loi
Phrased vs non-phrased reminiscence books,
St Vincent’s Research Endowment Fund
$15,000
NT Lautenschlager, P Desmond, K Cox, D Ames,
C Szoeke, O Salvado, M Sharman, K Ellis, P Phal
A randomised clinical trial of physical activity to delay
the progression of cerebrovascular disease in older
adults with memory complaints and mild cognitive
impairment, NHMRC
$632,152.80 for 2011–2013 ($148,735 (via NARI)
inВ 2012)
K Ellis, C Szoeke
Examination of burden associated with care
ofВ dementia patients: A longitudinal study, Pfizer
$495,600 over 3 years ($165,000 in 2012)
COLLABORATIONS IN RESEARCH
International
• University of Iowa – Huntington’s Study Group
• University of Rochester
• PREDICT 2.0 – University of Iowa
• PBT2 – University of Rochester
• University of Muenster Germany
• University of Iowa
• Cure Huntington’s Disease initiative
• Huntington’s Study Group
• European Huntington’s Disease Network
National
• La Trobe University, Bundoora, Victoria
• St Vincent’s Hospital Melbourne, Victoria
• National Ageing Research Institute, Parkville,
Victoria
• DTSC/La Trobe Uni – Improving dementia literacy
and empowering carers
• CL Psychiatry, St Vincent’s Hospital.
• National Ageing Research Institute, NARI
• Nursing Department, The University of Melbourne
st vincent’s research report 2012
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Aged Mental Health Service
• Huntington’s Research Group Victoria.
External Collaborators: Prof Nellie GeorgiouKaristianis, Prof Julie Stout, Monash University;
Prof Tony Hannan (Howard Florey Institute); A/
Prof Martin Delatycki (The Murdoch Children’s
Research Institute, Royal Children’s Hospital);
NARI; Huntington’s Victoria; Prof Dennis Velakoulis
(Neuropsychiatry Unit, Royal Melbourne Hospital)
• Huntington’s Victoria
• Westmead Hospital, NSW
• Royal Melbourne Hospital, Melbourne
• Perth Neurosciences Centre WA
PUBLICATIONS
Book chapters
NT Lautenschlager: There was no time to say
goodbye (case notes). In: Eyers K, Parker G
&В Brodaty H, editors, A guide for professionals
andВ carers: Managing depression growing older.
Allen & Unwin, Sydney, Melbourne, Auckland,
London, 2012: 166–167.
Loi S, Ames, D, O’Connor D, Lautenschlager
N. Chapter 17: Old Age Psychiatry. In: Castle
D, Bassett D (eds). Primer of Clinical Psychiatry,
2ndВ Edition. Elsevier. In press February 2012.
Szoeke C, Campbell S, Chiu E & Ames D. (2012)
Vascular cognitive disorder. In: Weiner MF & Lipton
A. (eds.), Clinical Manual of Alzheimer Disease and
Other Dementias, American Psychiatric Publishing,
Washington, DC. ISBN 978–1–58562–422–5:
171–191.
Ames D. (2012) Recurrent severe depression and
lithium. In: Eyers K, Parker G & Brodaty H. Managing
Depression Growing Older, Allen and Unwin, Sydney.
ISBN 978 1 74237 880 0: 214–215.
Journal articles
Nicola Lautenschlager
Almeida OP, Beer C, Lautenschlager NT,
ArnoldaВ L, Alfonso H and Flicker L. Two-year
courseВ of cognitive function and mood in adults with
congestive heart failure and coronary heart disease:
The Heart-Mind Study. International Psychogeriatrics
2012:24(1):38–47.
Suttanon P, Hill KD, Said CM, LoGiudice D,
Lautenschlager NT, Dodd KJ: Balance and mobility
dysfunction and falls risk in older people with mild
to moderate Alzheimer Disease. Am J Phys Med
Rehabil 2012;91(1):12–23.
Sona A, Zhang P, Ames D, Bush AI, Lautenschlager
NT, Martins R, Masters C, Rowe C, Szoeke C,
Taddei K, Ellis K, and the AIBL research group.
Predictors of rapid cognitive decline in Alzheimer’s
disease: results from the Australian Imaging,
Biomarkers and Lifestyle (AIBL) study of ageing.
International Psychogeriatrics 2012:24(2):197–204.
OP Almeida, GJ Garrido, C Beer, NT Lautenschlager,
L Arnolda, L Flicker: Cognitive and brain changes
associated with ischaemic heart disease and heart
failure. European Heart Journal 2012;33:1769–1776.
Dina LoGiudice, Kate Smith, David Atkinson,
EmilyВ Carroll, Frank Shaper, Geraldine Shadforth,
Rhonda Murphy, Nicola Lautenschlager,
LeonВ Flicker: Lungurra Ngoora: A pilot model
forВ care forВ aged and disabled in remote Australian
Aboriginal community – Can it work? Alzheimer’s
&В Dementia 2012;8(4)suppl2:S384 (abstract).
Elizabeth Cyarto, Patricia Desmond, David
Ames, Cassandra Szoeke, Olivier Salvado,
Matthew Sharman, Kathryn Ellis, Pramit Phal,
Colin Masters, Christopher Rowe, Ralph Martins,
NicolaВ Lautenschlager: AIBL Active: A randomized
controlled trial of physical activity to delay the
progression of white matter hyperintensities on
MRI in older adults at risk of cognitive decline.
Alzheimer’s & Dementia 2012;8(4)suppl2:S506–507
(abstract).
Kay Cox, Leon Flicker, Osvaldo Almeida, Kathryn
R. Greenop, Jacqueline Hendricks, Michael Phillips,
Nicola T. Lautenschlager: The predictors of shortand long-term physical activity levels of older adults
from FABS (Fitness for the Ageing Brain Study).
Alzheimer’s & Dementia 2012;8(4)suppl2:S82–83
(abstract).
Kay Cox, Leon Flicker, Osvaldo Almeida, Kathryn
Greenop, Jacqueline Hendricks, Michael Phillips,
Nicola Lautenschlager: Gender differences
inВ adherence to a home-based physical
activity program in older adults with memory
problems: FABS (Fitness for the Ageing Brain
Study). Alzheimer’s & Dementia 2012;8(4)
suppl2:S236–237 (abstract).
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Kay Cox, Leon Flicker, Osvaldo Almeida, Frank van
Bockxmeer, Kathryn Greenop, Jacqueline Hendriks,
Michael Phillips, Nicola Lautenschlager. Impact of
APOE e4 on the association of physical activity and
cognition in older adults with memory complaints.
Journal of Science and Medicine in Sport 2012;
15(6)suppl:58.
OP Almeida, B Draper, J Pirkis, J Snowdon,
NTВ Lautenschlager, G Byrne, M Sim, N Stocks,
N Kerse, L Flicker, JJ Pfaff: Social connectedness,
anxiety, depression and other risk factors associated
with suicidal thoughts in later life: rationale for the
implementation of preventive strategies. The British
Journal of Psychiatry 2012; 201:466–472.
AH Ford, GJ Garrid, C Beer, NT Lautenschlager,
LВ Arnolda, L Flicker and OP Almeida: Homocysteine,
grey matter and cognitive functionВ in adults with
cardiovascular disease. PloS ONE 2012;7(3):e33345.
EV Cyarto, NT Lautenschlager, PM Desmond,
DВ Ames, C Szoele, O Salvado, MJ Sharman,
KEВ Ellis, PM Phal, CM Masters, CC Rowe,
RNВ Martins and K Cox: Protocol for a randomized
controlled trial evaluating the effect of physical
activity on delaying the progression of white matter
changes or MRI in older adults with memory
complaints and mild cognitive impairment: the AIBL
Active trial. BMC Psychiatry 2012;12:167.
OP Almeida, J Pirkis, N Kerse, M Sim,
LВ Flicker, JВ Snowdon, B Draper, G Byrne,
NTВ Lautenschlager, N Stocks, H Alfonso,
JJВ Pfaff:В Socioeconomic Disadvantage Increases
RiskВ of Prevalent and Persistent Depression
in LaterВ Life. Journal of Affective Disorders
2012;138:322–331.
NT Lautenschlager: “Dementia in the21st century:
is the concept out-dated, and how to replace it”. In
Psychiatry in Australia 2012, a report from a meeting
of an Australian Psychiatrist Expert Group, Health
Education Australia Limited, pg. 6–9 (out of 70).
OP Almeida, J Pirkis, N Kerse, M Sim, L Flicker,
J Snowdon, B Draper, G Byrne, R Goldney, NT
Lautenschlager, N Stocks, H Alfonso, JJ Pfaff:
A Randomised trial to Reduce the Prevalence of
Depression and Self-Harm Behaviour in Older
Primary Care Patients. Annals of Family Medicine
2012;10:347–356.
NT Lautenschlager, R Ihl and WE MГјller: Ginkgo
biloba extract EGb 761В® in the context of current
developments in the diagnosis and treatment of
aged-related cognitive decline and Alzheimer’s
disease: a research perspective. International
Psychogeriatrics 2012;24(suppl 1):S46–S50.
OP Almeida, B Draper, J Pirkis, J Snowdon,
NTВ Lautenschlager, G Byrne, M Sim, N Stocks,
N Kerse, L Flicker, JJ Pfaff: Anxiety, depression
and comorbid anxiety and depression: risk
factors and outcome over two years. International
Psychogeriatrics 2012;24:10,1622–1632.
David Ames
Lee T, Mosing M, Wright M, Henry J, Trollor J,
Lammel A, Ames D, Martin N, Wright M, & Sachdev
P. (2012) Genetic influences on five measures of
processing speed and their covariation with general
cognitive ability in the elderly: the Older Australians
Twins study. Behaviour Genetics, 42: 96–106. doi:
10.1007/s10519–011–9474–1.
Sona A, Zhang P, Ames D, Bush AI, Lautenschlager
NT, Martins R, Masters C, Rowe C, Szoeke C,
Taddei K, Ellis K, and The AIBL Research Group
(2012) Predictors of rapid cognitive decline in
Alzheimer’s disease: results from the Australian
Imaging, Biomarkers and Lifestyle (AIBL) flagship
study of ageing. International Psychogeriatrics, 24:
197–204. doi: 10.1017/S1041610211001335 *
Pike KE, Kinsella GJ, Ong B, Mullaly E, Rand E,
Storey E, Ames D, Saling M, Clare L & Parsons S.
(2012). Names and numberplates: quasi-everyday
associative memory tasks for distinguishing
amnestic mild cognitive impairment from healthy
ageing. Journal of Clinical and Experimental
Neuropsychology, 43: 269–278.
Delprado J, Kinsella G, Ong B, Pike K, Ames D,
Storey E, Saling M, Clare L, Mulally E & Rand E.
(2012) Clinical measures of prospective memory
inВ amnestic mild cognitive impairment. Journal of
theВ International Neuropsychological Society, 18:
295–304. doi.org/10.1080/13803395.2011.633498
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Hutchens R, Kinsella GJ, Ong B, Pike KE, Parsons
S, Storey E, Ames D, Saling MM, Mullaly E, Rand
E & Clare L. (2012) Knowledge and use of memory
strategies in amnestic mild cognitive impairment.
Psychology and Ageing, epublished ahead of print
accepted 29/9/11 doi: 10.1037/a0026256.
ChГ©telat G, Villemagne VL, Pike KE, Ellis K, Ames D,
Masters CL, Rowe CR & The AIBL Research Group.
(2012) Relationships between memory performance
and ОІ amyloid deposition at different stages of
Alzheimer’s disease. Neurodegenerative Diseases,
10: 141–144. doi: 10:1159/000334295.
Lim YY, Ellis K, Harrington K, Ames D, Martins R,
Masters C, Rowe C, Szoeke C, Darby D, & Maruff
P. (2012) Use of the COGSTATE brief battery in the
assessment of Alzheimer’s disease related cognitive
impairment in the Australian Imaging, Biomarkers
and Lifestyle (AIBL) study. Journal of Clinical and
Experimental Neuropsychology, 34: 345–358. doi:
10.1080/13803395.2011.643227.
Lim YY, Harrington K, Ames D, Ellis KA, Lachovitszki
R, Snyder P & Maruff P. (2012) Short term stability
of verbal memory impairment in mild cognitive
impairment and Alzheimer’s disease measured
using the International Shopping List Test. Journal
of Clinical and Experimental Neuropsychology, 34:
853–863. . doi: 10.1080/13803395.2012.689815.
Lee T, Mosing M, Henry J, Trollor J, Ames D, Martin
NG, Wright M, Sachdev P & The OATS Team. (2012)
Genetic influence on four measures of executive
function and their covariation with general cognitive
ability: the Older Australians Twins study. Behavior
Genetics, 42: 539–540 doi: 10.1007/s10519–012–
9526–1.
ChГ©telat G, Villemagne Vl, Villain N, Jones G,
EllisВ K, Ames D, Masters CL, Rowe CR & The
AIBL Research Group. (2012) Accelerated cortical
atrophy in cognitively normal elderly with high
β-amyloid deposition. Neurology, 78:477–484. doi:
10.1212/WNL.0b013e318246d67a. This paper
was awarded Best Paper 2012 de Leon Prize
inВ Neuroimaging from the international Society
to Advance Alzheimer’s Research and Treatment
(ISTAART).
Doecke JD, Laws SM, Faux NG, Wilson W, Burnham
SC, Lam C-P, Mondal A, Bedo J, Bush AI, Brown
B, De Ruyck K, Ellis KA, Fowler C, Gupta VB, Head
R, Macauley L, Pertile K, Rowe CC, Rembach A,
Rodrigues M, Rumble R, Szoeke C, Taddei K, Taddei
T, Trounson B, Ames D, Masters CL, Martins RN
for the Alzheimer’s Disease Neuroimaging Initiative
and The AIBL Research Group. (2012) Blood based
protein biomarkers for diagnosis of Alzheimer’s
disease. Archives of Neurology, 69: 1318–1325.
Lim YY, Ellis KA, Pietrzak RH, Ames D, Darby D,
Harrington K, Martins RN, Masters CL, Rowe C,
Savage G, Szoeke C, Villemagne V, & Maruff P for
The AIBL Research Group. (2012) Stronger effect
of amyloid load than APOE genotype on cognitive
decline in healthy older adults. Neurology, 79:
1645–1652. doi:
Batouli SAH, Sachdev PS, Wen W, Wright MJ,
SuoВ C, Ames D & Trollor JN. (2012) The heritability
of brain metabolites on protein magnetic resonance
spectroscopy in older individuals. Neuroimage, 62:
281–289. doi: 10/1016/j.neuroimage.2012.04.043.
Villain N, ChГ©telat G, Grassiot B, Bourgeat P,
JonesВ G, Ellis KA, Ames D, Martins RN, EustacheВ F,
Salvado O, Masters CL, Rowe CR, Villemagne Vl,
and The AIBL Research Group. (2012) Regional
dynamics of ОІ-amyloid deposition in healthy elderly,
Mild Cognitive Impairment and Alzheimer’s disease:
a voxelwise PiB-PET longitudinal study. Brain, 135:
1226–1239. doi:10.1093/brain/aws125.
Brown BM, Peiffer JJ, Taddei K, Lui J, Laws S,
Gupta VB, Taddei T, Ward VK, Rodrigues M,
Burnham S, Rainey-Smith S, Bush A, Ellis KA,
Masters CL, Ames D, Macauley SL, Szoeke C,
Rowe CC, Martins RN For The AIBL Research
Group. (2012) Physical activity and amyloid-plasma
and brain levels: results from the Australian Imaging,
Biomarkers and Lifestyle study of ageing. Molecular
Psychiatry, epublished ahead of press, doi: 10.1038/
mp.2012.107.
Dow B, Cortes-Simonet N, Ellis K, Hempton C,
Koch S, Logiudice D, Mastwyk M, Livingston G,
Cooper C & Ames D. (2012) Students’ perceptions
of elder abuse, Australasian Journal on Ageing
epublished ahead of print doi: 10.1111/j.1741–
6612.2012.00643.x.
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Gardener S, Gu Y, Rainey-Smith S, Keogh JB,
Clifton PM, Mathieson SL, Taddei K, Mondal A,
Ward VK, Scarmeas N, Barnes M, Ellis KA, Head
R, Masters CL, Ames D, Macaulay L, Rowe CR,
Szoeke C, Martins R for the AIBL Research Group.
(2012) Adherence to a Mediterranean diet and
Alzheimer’s disease risk in an Australian population.
Translational Psychiatry, e-published ahead of press,
doi: 10.1038/tp.2012.91.
Verdile G, Laws SM, Henley D, Ames D, Bush A,
Ellis KA, Faux NG, Gupta VB, Li QX, Lui JK, Masters
CL, Pike KE, Rowe CC, Wilson W, Burnaham SC,
Lam C-P, Mondal A, Bedo J, Bush AI, Szoeke C,
Taddei K, Villemagne and Martins RN for the AIBL
Research Group. (2012) Associations between
gonadotropins, testosterone and AОІ in men at risk of
Alzheimer’s disease. Molecular Psychiatry, in press,
accepted 5.9.12.
Lim YY, Pietrzak R, Ellis K, Jaeger J, Harrington
K, Ashwood T, Szoeke C, Martins RN, Bush AI,
Masters CL, Rowe C, Villemagne V, Ames D, Darby
D, & Maruff P. (2012) Rapid decline in episodic
memory in healthy older adults with high ОІ amyloid.
Journal of Alzheimer’s Disease, in press.
Chong TWH, Doyle CJ, Cyarto EV, Cox KL, Ellis
KA, Ames D, Lautenschlager NT and the AIBL
investigators. (2012) Perspectives on physical
activity programs to support brain health for older
adults with and without cognitive impairment. Asia
Pacific Psychiatry, in press, accepted 25.9.12.
Brown BM, Peiffer JJ, Sohrabi HR, Mondal A,
Burnham S, Gupta VB, Rainey-Smith S, Taddei K,
Ellis KA, Szoeke C, Masters CL, Ames D, RoweВ CC,
Martins RN & The AIBL Research Group. (2012)
Intense physical activity is associated with cognitive
performance in the elderly. Translational Psychiatry,
in press, accepted 6.10.12.
Cyarto E, Lautenschlager N, Desmond P, AmesВ D,
Szoeke C, Salvado O, Sharman M, Ellis KA,
PramitВ PM, Masters CM, Rowe CC, Martins RN &
Cox K. (2012) Protocol for a randomized controlled
trial evaluating the effect of physical activity in
delaying the progression of white matter changes
on MRI in older adults with emmory complaints
and mild cognitive impairment: the AIBL Active trial.
BMC Neurology, 12: 167. doi: 10.1186/1471–244X–
12–167.
Review Articles – David Ames:
Moore E, Mander A, Ames D, Carne RP, Sanders
KM & Watters DAK. (2012) Cognitive impairment and
vitamin B12: a review. International Psychogeriatrics,
24: 541–556. doi:10.1017/S1041610211002511.
Cooper C, Mukadam N, Katona C, Lyketsos CG,
Ames D, Rabins P, Engedal K, De Mendonça
Lima C, Blazer D, Teri L, Brodaty H, & Livingston
G. (2012) Systematic review of the effectiveness
of non-pharmacological interventions to improve
quality of life and wellbeing in people with dementia.
International Psychogeriatrics, 24: 856–870. doi:
10.1017/S1041610211002614.
Head R, Ames D, Masters CL, Rowe CC &
Macauley L. (2012) The AIBL study: throwing light
on amyloid and Alzheimer’s disease. Medical Journal
of Australia, 196: 376. doi: 10.5694/mja12.10488.
Cooper C, Mukadam N, Katona C, Lyketsos
CG, Blazer D, Ames D, Rabins P, Brodaty H, De
Mendonça Lima C & Livingston G. (2012) Systematic
review of the effectiveness of pharmacological
interventions to improve quality of life and wellbeing
in people with dementia. American Journal of
Geriatric Psychiatry, published ahead of press doi:
10.1097/JGP.0b013e31823e31a2.
Carillo MC, Rowe CR, Masters CL, Szoeke C, Ames
D, O’Meara T, Macaulay SL, Milner A, Ellis KA,
Maruff P, Rainey-Smith SR, Martins RN, Bain LJ &
Head R. Research and standardization in Alzheimer’s
trials: reaching international consensus. Alzheimer’s
and Dementia, in press accepted October 2012.
Sam Loi
Curran E, Loi S. Depression in dementia. Medical
Journal of Australia Open. 1 Supplement. 4: 40–43.
October 2012.
Loi S. eMims Disease Index. Psychiatric disorders in
the elderly: Depression and dementia. August 2012.
Loi S, Chiu E. Witchcraft and Huntington’s
Disease – a salutary history of societal and medical
stigmatisation. Australasian Psychiatry. 20 (5):
438–441. 2012.
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Goh, A., Kelleher, R.,Yastrubetskaya, O., Taylor,
M., Chiu, E., & Lautenschlager, N. Pastoral Care in
Old Age Psychiatry: A quality assurance evaluation
undertaken at St Vincent’s Aged Mental Health
Service. Asia Pacific Psychiatry, in press.
Cyarto EV, Lautenschlager NT, Desmond PM,
et al. Protocol for a randomized controlled trial
evaluating the effect of physical activity on delaying
the progression of white matter changes on MRI
in olderВ adults with memory complaints and
mild cognitive impairment: The AIBL Active trial.
BMCВ Psychiatry 2012;12:167.
Walterfang, M., Goh, A., Mocellin, R., Evans, A.,
& Velakoulis, D. (2012). Peduncular Hallucinosis
secondary to central pontine myelinolysis. Psychiatry
and Clinical Neurosciences, 66, 618–621
Doecke JD, Laws SM, Faux NG, et al. Blood-based
protein biomarkers for diagnosis of Alzheimer
disease. Arch Neurol 2012;69:1318–1325.
Anita Goh
Kathryn Ellis
Acosta O, Fripp J, Dore V, et al. Cortical surface
mapping using topology correction, partial flattening
and 3D shape context-based non-rigid registration
for use in quantifying atrophy in Alzheimer’s disease.
J Neurosci Methods 2012;205:96–109.
Barber B, Ames D, Ellis K, Martins R, Masters C,
Szoeke C. Lifestyle and late life cognitive health:
sufficient evidence to act now? Int Psychogeriatr
2012;24:683–688.
Brown BM, Peiffer JJ, Sohrabi HR, et al. Intense
physical activity is associated with cognitive
performance in the elderly. Transl Psychiatry
2012;2:e191.
Brown BM, Peiffer JJ, Taddei K, et al. Physical
activity and amyloid-beta plasma and brain levels:
results from the Australian Imaging, Biomarkers
andВ Lifestyle Study of Ageing. Mol Psychiatry 2012.
Carrillo MC, Rowe CC, Szoeke C, et al. Research
and standardization in Alzheimer’s trials: Reaching
international consensus. Alzheimers Dement 2012.
Chetelat G, Villemagne VL, Pike KE, et al.
Relationship between memory performance
and beta-amyloid deposition at different stages
of Alzheimer’s disease. Neurodegener Dis
2012;10:141–144.
Chetelat G, Villemagne VL, Villain N, et al.
Accelerated cortical atrophy in cognitively normal
elderly with high beta-amyloid deposition. Neurology
2012;78:477–484.
Gardener S, Gu Y, Rainey-Smith SR, et al. Adherence
to a Mediterranean diet and Alzheimer’s disease
risk in an Australian population. Transl Psychiatry
2012;2:e164.
Lim YY, Ellis KA, Ames D, et al. Abeta amyloid,
cognition, and APOE genotype in healthy older
adults. Alzheimers Dement 2012.
Lim YY, Ellis KA, Harrington K, et al. Use of the
CogState Brief Battery in the assessment of
Alzheimer’s disease related cognitive impairment
in the Australian Imaging, Biomarkers and Lifestyle
(AIBL) study. J Clin Exp Neuropsychol 2012;34:345–
358.
Lim YY, Ellis KA, Pietrzak RH, et al. Stronger
effect of amyloid load than APOE genotype on
cognitive decline in healthy older adults. Neurology
2012;79:1645–1652.
Lim YY, Harrington K, Ames D, et al. Short term
stability of verbal memory impairment in mild
cognitive impairment and Alzheimer’s disease
measured using the International Shopping List Test.
J Clin Exp Neuropsychol 2012;34:853–863.
Macpherson H, Ellis KA, Sali A, Pipingas A. Memory
improvements in elderly women following 16 weeks
treatment with a combined multivitamin, mineral and
herbal supplement: A randomized controlled trial.
Psychopharmacology (Berl) 2012;220:351–365.
Sona A, Zhang P, Ames D, et al. Predictors of rapid
cognitive decline in Alzheimer’s disease: results from
the Australian imaging, biomarkers andВ lifestyle (AIBL)
study of ageing. Int Psychogeriatr 2012;24:197–204.
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Verdile G, Laws SM, Henley D, et al. Associations
between gonadotropins, testosterone and beta
amyloid in men at risk of Alzheimer’s disease. Mol
Psychiatry 2012.
Villain N, Chetelat G, Grassiot B, et al. Regional
dynamics of amyloid-beta deposition in healthy
elderly, mild cognitive impairment and Alzheimer’s
disease: a voxelwise PiB-PET longitudinal study.
Brain 2012;135:2126–2139.
Conference publications
David Ames
Bourgeat P, Raniga P, Salvado O, DorГ©, Zhou L,
Martins R, Macaulay L, Masters C, Ames D, Ellis K,
Villemagne V, Rowe P, Fripp J & The AIBL Research
Group. (2012) Classification of Alzheimer’s subject
based on PIB-MR manifold learning. Alzheimer’s and
Dementia, 8 (Suppl. 2): P28.
Bourgeat P, Fripp J, Raniga P, DorГ©, Zhou L,
Martins R, Macaulay L, Masters C, Ames D, Ellis
K, Villemagne V, Rowe C, Salvado O & The AIBL
Research Group. (2012) Longitudinal modeling
of joint PIB/MRI changes in Alzheimer’s disease.
Alzheimer’s and Dementia, 8 (Suppl. 2): P28.
DorГ©, Fripp J, Bourgeat P, Acosta O, Zhou L, Raniga
P, Martins R, Macauley L, Ellis K, Masters C, Ames
D, Villemagne V, Rowe C, Salvado O & The AIBL
Research Group. (2012) Longitudinal analysis of
cortical thickness in PIB+ and PIB- healthy elderly
controls. Alzheimer’s and Dementia, 8 (Suppl. 2):
P34.
Raffelt D, Tournier JD, Crozier S, Ellis K, Martins R,
Villemagne V, Masters C, Ames D, Rowe C, Salvado
O & Connelly A. (2012) Apparent fibre density: a
novel MRI approach that identifies specific white
matter tracts affected by Alzheimer’s disease and
MCI. Alzheimer’s and Dementia, 8 (Suppl. 2): P61.
Gupta V, Wilson A, Rainey-Smith S, Laws SM, Bush
A, Ellis K, Macaulay L, Rowe C, Szoeke C, Taddei
K, Ames D, Masters C, Martins R & The AIBL
Research Group. (2012) Establishing apolipoprotein
E as a biomarker for Alzheimer’s disease: Australian
Imaging, Biomarker and Lifestyle study of ageing.
Alzheimer’s and Dementia, 8 (Suppl. 2): P110.
Villemagne V, Ellis K, ChГ©telat, Brown B, Bourgeat P,
Jones G, Martins R, Salvado O, Ames D, Masters
C & Rowe C. (2012) Relation between rates of AОІ
deposition, APOE genotype and cognition: results
from a 3- to 5-year longitudinal study. Alzheimer’s
and Dementia, 8 (Suppl. 2): P113.
Burnham S, Wilson W, Graham P, Kiiveri H, AmesВ D,
Macaulay L, Martins R, Masters C, Rowe C,
SalvadoВ O, Szoeke C, Villemagne V, AIBL Research
Group & Ellis K. (2012) Cognitive assessments
asВ estimators of neocortical beta-amyloid burden
in the AIBL cohort. Alzheimer’s and Dementia, 8
(Suppl. 2): P130.
Burnham S, Graham P, Wilson W, Ames D,
Macaulay L, Martins R, Masters C, Marruff P, Rowe
C, Szoeke C, AIBL Research Group, Ryan L, & Ellis
K. (2012) Intensity of dementia though latent variable
modelling (1-DELV) in the AIBL cohort. Alzheimer’s
and Dementia, 8 (Suppl. 2): P131.
Evered L, Silbert B, Ames D, Marruff P & Scott
D. (2012) Does general anaesthesia exacerbate
Alzheimer’s disease? Alzheimer’s and Dementia,
8 (Suppl. 2): P208–P209.
Kinsella G, Ames D, Storey E, Ong B, Pike K,
Mullally E, Rand E, Clare L, Saling M & Parsons
S. (2012) Knowledge-transfer following cognitive
intervention for amnestic mild cognitive impairment.
Alzheimer’s and Dementia, 8 (Suppl. 2): P235.
DorГ©, Fripp J, Bourgeat P, Acosta O, Zhou L,
RanigaВ P, Martins R, Macauley L, Ellis K, MastersВ C,
Ames D, Villemagne V, Rowe C, Salvado O &
The AIBL Research Group. (2012) Longitudinal
analysis of cortical thickness in PIB+ and PIB–
healthy elderly controls. Alzheimer’s and Dementia,
8В (Suppl.В 2): P248.
Faux N, Burnham S, Wilson W, Jones G, LawsВ S,
Bedo J, Ames D, Bush Ai, Doecke J, Ellis K,
HeadВ R, Kiiveri H, Macaulay L, Martins R, MastersВ C,
Rowe C, Salvado O, Szoeke C, Villemagne V, &
TheВ AIBL Research Group. (2012) An update on
anВ AIBL blood-based biomarker panel for the
prediction of Aβ burden. Alzheimer’s and Dementia,
8 (Suppl. 2): P283.
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Appannah A, Szoeke C, Ellis K, Rowe C, Martins R,
Masters C, Ames D, Bush A & The AIBL Research
Group. (2012) Investigating cardiovascular risk
factors on cognition: a two cohort study. Alzheimer’s
and Dementia, 8 (Suppl. 2): P318.
Grigg J, Szoeke C, Ellis K, Rowe C, Desmond
P, Masters C & Ames D. (2012) AIBLWHAP:
methodology and baseline characteristics of a
population-based sample recruited for a longitudinal
study of risk factors and later-life cognitive decline.
Alzheimer’s and Dementia, 8 (Suppl. 2): P321–P322.
Bourgeat P, Raniga P, Salvado O, DorГ©, Zhou L,
Martins R, Macaulay L, Masters C, Ames D, Ellis K,
Villemagne V, Rowe P, Fripp J & The AIBL Research
Group. (2012) Classification of Alzheimer’s subject
based on PIB-MR manifold learning. Alzheimer’s and
Dementia, 8 (Suppl. 2): P344.
Bourgeat P, Fripp J, Raniga P, DorГ©, Zhou L,
Martins R, Macaulay L, Masters C, Ames D, Ellis
K, Villemagne V, Rowe C, Salvado O & The Aibl
Research Group. (2012) Longitudinal modeling
of joint PIB/MRI changes in Alzheimer’s disease.
Alzheimer’s and Dementia, 8 (Suppl. 2): P345.
Jones A, Graham P, Ellis K, Ames D, Savage G
& AIBL Research Group. (2012) Can memory
profiling predict progression to Alzheimer’s disease
in amnestic Mild Cognitive Impairment? Alzheimer’s
and Dementia, 8 (Suppl. 2): P358.
Laws S, Bender S, Rainey-Smith S, Wilson A, Gupta
VB, De Ruyck K, Bush A, Ellis K, Macaulay L, Rowe
C, Szoeke C, Taddei K, Ames D, Masters C, Martins
R & The AIBL Study Group. (2012) Alzheimer’s
disease-related changes in plasma cortisol levels
and gene involvement in the AIBL study. Alzheimer’s
and Dementia, 8 (Suppl. 2): P407.
Rainey-Smith S, Brown B, De Ruyck K, Laws S,
Wilson A, Gupta VB, Ames D, Ellis K, Taddei K,
Head R, Macaulay L, Masters C, Rowe C, Szoeke
C, Martins R & The AIBL Research Group. (2012)
Alzheimer’s disease-related changes in plasma
brain-derived neurotrophic factor levels: data from
the AIBL study. Alzheimer’s and Dementia, 8 (Suppl.
2): P407–P408.
Rowe C, Ellis K, Brown B, Bourgeat P, Faux N,
Martins R, Salvado O, Masters C, Ames D &
Villemagne V. (2012) Cognition, hippocampal volume
and fibrillar AОІ burden as predictors of cognitive
decline: three-year follow-up results from AIBL.
Alzheimer’s and Dementia, 8 (Suppl. 2): P433.
Lim YY, Ellis K, Ames D, Harrington K, Martins
R, Masters C, Rowe C, Savage G, Szoeke
C, Villemagne V, Pietrzak R, Maruff P & AIBL
Research Group. (2012) Effect of AОІ burden
andВ apolipoprotein E Оµ4 on cognitive decline
at 18 months in healthy older adults. Alzheimer’s
andВ Dementia, 8 (Suppl. 2): P439.
Ellis K, Maruff P, Martins R, Masters C, Mcbride S,
Macaulay L, Rowe C, Rainey-Smith S, Rembach A,
Savage G, Szoeke C, Taddei K, Villemagne V, Zhang
P, Ames D & AIBL Research Group. (2012) Rates of
conversion to MCI and Alzheimer’s in the Australian
Imaging, Biomarkers and Lifestyle (AIBL) cohort over
36months. Alzheimer’s and Dementia, 8 (Suppl. 2):
P484–485.
Szoeke C, Ellis K, Zhang P, Rowe C, Martins R,
Masters C, Ames D & AIBL Research Group. (2012)
A return to clinical skills in the early diagnosis of
Alzheimer’s disease. Alzheimer’s and Dementia,
8В (Suppl. 2): P491.
Brown B, Peiffer J, Gupta VB, Taddei K, SalvadoВ O,
Villemagne V, Rainey-Smith S, Ellis K, Ames D,
Rowe C, Masters C, Szoeke C, Martins R & AIBL
Research Group. (2012) Level of physical activity is
associated with hippocampal atrophy in a subgroup
of the AIBL cohort. Alzheimer’s and Dementia,
8В (Suppl. 2): P494.
Chen K, Lowndes G, Ames D & Szoeke C.
(2012) Variability in mid-life high density lipoprotein
cholesterol (HDL-C) is related to poorer late-life
episodic memory: the Women’s Healthy Ageing
Project (WHAP). Alzheimer’s and Dementia, 8
(Suppl.В 2): P499.
Gardner S, Rainey-Smith S, Gu Y, Taddei K, LawsВ S,
Gupta VB, Ames D, Ellis K, Head R, MacaulayВ L,
Masters C, Rowe C, Szoeke C, Clifton P, KeoghВ J,
Scarmeas N, Martins R & AIBL Research Group.
(2012) Diet, neuroimaging biomarkers and
Alzheimer’s disease: data from the Australian
Imaging, Biomarkers and Lifestyle study of Ageing.
Alzheimer’s and Dementia, 8 (Suppl. 2): P503.
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Aged Mental Health Service
Cyarto E, Cox K, Desmond P, Ames D, SzoekeВ C,
Salvado O, Sharman M, Ellis K, Phal P, MastersВ C,
Rowe C, Martins R & Lautenschlager N. (2012)
AIBL Active: a randomized controlled trial of
physical activity to delay the progression of white
matter hyperintensities on MRI in older adults at
risk of cognitive decline. Alzheimer’s and Dementia,
8В (Suppl. 2): P506.
Kamer A, Ellis K, Kinsella G, Ames D, Martins
R, Rowe C, Macaulay L, Szoeke C, Masters C,&
AIBL Research Group. (2012) APOE and cognitive
dysfunction in Alzheimer’s dementia and Mild
Cognitive Impairment. Alzheimer’s and Dementia,
8 (Suppl. 2): P537–538.
Ellis K, Lim YY, Ames D, Darby D, Harrington
K, Martins R, Masters C, Rowe C, Savage G,
SzoekeВ C, Villemagne V, Maruff P & AIBL Research
Group. (2012) AОІ amyloid, cognition and APOE
genotype in the preclinical stages of Alzheimer’s
disease. Alzheimer’s and Dementia, 8 (Suppl. 2):
P556–557.
Lim YY, Harrington K, Ellis K, Ames D, AshwoodВ T,
Jaeger J, Lachovitzki R, Martins R, Masters C,
RoweВ C, Savage G, Szoeke C, Villemagne V,
Darby D & Maruff P. (2012) The Australian Imaging,
Biomarkers and Lifestyle-Rate of Change sub-study:
rationale, design, acceptability and pilot data for the
first three months of assessment. Alzheimer’s and
Dementia, 8В (Suppl. 2): P557.
Chua C, Henderson V, Ames D, Dennerstein L &
Szoeke C. (2012) DHEAS and cognitive function
in post-menopausal women: the Women’s Healthy
Aging study. Alzheimer’s and Dementia, 8 (Suppl.
2): P575.
Chen K, Lowndes G, Ames D, & Szoeke C. (2012)
The influence of midlife cholesterol on late-life
cognition: the Women’s Healthy Ageing Project
(WHAP). Alzheimer’s and Dementia, 8 (Suppl. 2):
P596.
Yates P, Desmond P, Raniga P, Phal P, Steward C,
Salvado O, Martins R, Salinas S, Ellis K, Szoeke C,
Masters C, Ames D, & Rowe C. (2012) Incidence
and associations of lobar microbleeds: results from
the Australian Imaging, Biomarkers and Lifestyle
study of ageing (AIBL). Alzheimer’s and Dementia,
8В (Suppl. 2): P616.
Restrepo C, Saling M, Yates P, Villemagne V,
AmesВ D, Bush A, Faux N, Martins R, Masters
C, Rowe C, Szoeke C, Ellis K & AIBL Research
Group. (2012) The effects of vascular risk factors
onВ cognition in older adults: data from the AIBL
study. Alzheimer’s and Dementia, 8 (Suppl. 2): P635.
Sachdev P, Trollor A, Lammel A, Lee T, Wright M,
Ames D, Brodaty H, Wen W & The OATS Research
Team. (2012) Recent findings from the Older
Australians Twins Study (OATS). Alzheimer’s and
Dementia, 8 (Suppl. 2): P675.
Laws S, Lam Cp, Mondal A, Bush A, Ellis K,
Macaulay L, Rowe C, Taddei K, Szoeke C,
AmesВ D, Masters C, Martins R & The AIBL Study
Group (2012) Gene combination associations with
Alzheimer’s disease risk and quantitative traits in the
IBL study. Alzheimer’s and Dementia, 8 (Suppl. 2):
P678.
Raffelt D, Tournier JD, Crozier S, Ellis K, Martins R,
Villemagne V, Masters C, Ames D, Rowe C, Salvado
O & Connelly A. (2012) Apparent fibre density: a
novel MRI approach that identifies specific white
matter tracts affected by Alzheimer’s disease and
MCI. Alzheimer’s and Dementia, 8 (Suppl. 2): P690.
Anita Goh
Goh AMY. (2012) The Behavioural and Psychological
Symptoms of Huntington’s Disease: A practical
guide to assist in caring for a person with HD.
Clinical Genetics, 80 (Suppl. 1): 65.
Samantha Loi
Loi S. IMPACCT – Improving mood and physical
activity in carers and care recipient trial. International
Psychogeriatric Association conference, Cairns,
September 2012.
Loi S. Poster presentation – The Dementia
Behavioural Management Advisory Service Northern
Territory and Regional Victoria Pilot Program. IPA,
Cairns, September 2012.
Hocking D, Loi S, Silberberg C, Sundram S, Sevar
K. Seeking asylum in Australia: from cells to circuits
to syndromes. RANZCP College Congress, Hobart,
May 2012.
st vincent’s research report 2012
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Aged Mental Health Service
Speaking engagements
Nicola Lautenschlager
Physical activity and cognitive activity to support
brain health in old age: evidence, challenges and
translation, Australian Association of Gerontology
Inc. Evening Forum, Kew, February 2012
Lifestyle Approaches for the Prevention of
Alzheimer’s Disease, McClusker Alzheimer’s
Research Foundation, Perth, March 2013
Could physical activity delay cognitive decline in
older adults with vascular risk factors, Research and
Standardization in Alzheimer’s Disease International
Conference, March 2012
Physical activity and cognitive activity to support
brain health in old age: evidence, challenges and
translation, Royal Perth Hospital, April 2012
Physical Activity and Cognitive Function, 17th
Malaysian Conference on Psychological Medicine,
Kuala Lumpur, June 2012
Reflecting on the New Alzheimer’s Disease Criteria,
17th Malaysian Conference on Psychological
Medicine, Kuala Lumpur, June 2012
Improving mental health outcomes in old age:
howВ to reduce the risk of cognitive decline,
AgedВ &В Community Care Victoria State Congress,
Melbourne, June 2012
Panel Chair, Social Behavioural and Care Research
and Practice: Cognitive Training and Physical
Exercise Interventions, Alzheimer’s Association
International Conference 012, Canada, July 2012
Gender differences in adherence to a home-based
physical activity and cognitive function in adults
with cognitive impairment: Alzheimer’s Association
International Conference 012, Canada, July 2012
Physical and cognitive activity for the aging brain:
evidence, challenges and translation, Austin
Mental Health Clinical Services Unit Grand Round,
Melbourne, Jul 2012
AUPOA presentation, Building Linkages, Department
of Psychiatry Annual Research Symposium,
University of Melbourne, Melbourne, August 2012
How to support cognitive function in old age:
what are the protective and risk factors currently
discussed in research, St George’s Hospital Grand
Round, Melbourne, August 2012
Causes of Cognitive Impairment and Dementia:
Diagnosis, Prognosis and Management, The New
Zealand Association of Gerontology Ageing and
Diversity Conference, Auckland, September 2012
Cognitive impairment: current knowledge on
prevention and management, and what the future
might hold, The New Zealand Association of
Gerontology Ageing and Diversity Conference,
Auckland, September 2012
How to publish your research successfully,
International Psychogeriatric Association
InternationalВ Meeting 2012, Cairns, September 2012
Cognitive impairment in the 21st Century: is
theВ concept of dementia outdated and what
willВ the future hold? Chinese Dementia Research
Association Ltd. 3rd Annual General Meeting cum
Scientific Symposium, Hong Kong, September 2012
Non-pharmacological Interventions for Older Adults
with Memory Complaints, Mild Cognitive Impairment,
Academic Lecture, The Chinese University of
HongВ Kong, Hong Kong, September 2012
Dementia: Evidence, Challenges and Translation,
Academic Lecture, The Chinese University of
HongВ Kong, Hong Kong, September 2012
Risk factors and environmental strategies for
managing cognitive decline, RANZCP Faculty of
Psychiatry of Old Age Advanced Trainees Meeting,
Melbourne, October 2012
AIBL active update, CRC and AIBL Research
Conference, Melbourne, November 2012
Update on the Journey of Physical Activity
and theВ Ageing Brain or how to Navigate the
Challenges of Clinical Research, Eric Seal Seminar,
St Vincent’s Hospital, Melbourne, November 2012
Sam Loi
Mental health service development in the elderly
– the Victorian experience. Pacific Rim College
ofВ Psychiatrists, Seoul, October 2012
FABSII and the AIBL Active research studies,
NARIВ Board Meeting, Melbourne, August 2012
st vincent’s research report 2012
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Aged Mental Health Service
Anita Goh
David Ames
Characterisation of a large group of individuals
with Huntington’s disease and their relatives enrolled
in the COHORT study – a longitudinal analysis
of data. HSG Annual Meeting and Sixth annual
HD Clinical Research Symposium, Seattle, USA,
November 2012
Amyloid imaging, blood biomarkers and lifestyle
factors in the detection and prevention of early
Alzheimer’s disease: the Australian Imaging,
Biomarkers and Lifestyle (AIBL) study of ageing.
Topics in de Ouderengeneesknude en Ouderenzorg,
Maastricht, the Netherlands, 8 March 2012
Working together globally to advance knowledge
on Huntington’s disease. Invited speaker at
Clinical Research at St Vincent’s: Academic
and Translational Updates in Mental Health.
27В September 2012
Alzheimer’s disease: why does it matter to everybody
and what are we doing about it? Plenary address First
World Congress on Healthy Ageing, Kuala Lumpur,
Malaysia, 19 March 2012
Providing Spiritual Care to Older Adults with Mental
Illness in a Culturally Diverse Community. International
Psychogeriatric Association International Meeting
2012, Cairns, 9 September 2012
Huntington’s Disease Research Clinic in the AUPOA:
17 years of research, advocacy, collaboration and
education. University of Melbourne Department of
Psychiatry Research Symposium 26 August 2012
Kathryn Ellis
The Research and Standardisation in Alzheimer’s
disease meeting, Melbourne, Australia, March 2012
The ANZSGM Scientific meeting, September 20.
Melbourne, Australia, September 2012
The CRC for Mental Health Annual Review,
November. Melbourne Australia, November 2012
Rosemary Kelleher
International Psycho-geriatric Association Annual
Congress, Cairns, Qld. Session Chair for Concurrent
Session: Special Care Issues in Later Life.
Presentation: A Voice at the Table: An integrated
model for pastoral care in aged mental health.
Co-authored with A. Goh, N.T.Lautenschlager,
D.Ames,M.Taylor, E.Chiu, O. Yastrubetskaya,
September 2012
Centre for Ageing and Pastoral Studies Biennial
Conference, ANU, Canberra. Session Chair:
Knowledge and Practice Development in spirituality
and ageing. Presentation: How clinical awareness
can be useful. A model for providing pastoral care
for older people with mental illness and their families.
September 2012
Detection and management of late-life depression.
Invited symposium, First World Congress on Healthy
Ageing, Kuala Lumpur, Malaysia, 20 March 2012
Ames D, Elllis K, Morris J, Petersen R, Maruff P &
Savage G. Current issues in cognitive assessment
for Alzheimer’s disease research (panel discussion –
chair). Research and Standardization in Alzheimer’s
Disease, Melbourne, Australia, 27 March 2012
Consumers and researchers fighting Alzheimer’s
disease together – response (public lecture).
Research and Standardization in Alzheimer’s
Disease, Melbourne, Australia, 27 March 2012
Closing remarks. Research and Standardizathion
in Alzheimer’s Disease, Melbourne, Australia,
29В March 2012
Is there a clinical imperative for research?
Anesthesiology and Alzheimer’s Symposium:
the Role of Anesthesia in Alzheimer’s Disease,
Vancouver, Canada, 14 July 2012
Ames D, Knopman D & Silbert B. Panel discussion:
measuring dementia outcomes in clinical research.
Anesthesiology and Alzheimer’s Symposium:
the Role of Anesthesia in Alzheimer’s Disease,
Vancouver, Canada, 14 July 2012
Woodward M & Ames D. How long before she
goesВ to a nursing home? Workshop given 3 times.
The 2012 Masterclass in Alzheimer’s disease,
Melbourne 25–26 February 2012
Ames D, Darby D, Dorevitch M, Draper B,
HopwoodВ M, James K. & McCabe M. Clinical
counundrums – panel discussion. The 2012
Masterclass in Alzheimer’s Disease, Melbourne
26В February 2012
st vincent’s research report 2012
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Aged Mental Health Service
Ames D & the AIBL investigators. Three year follow
up results from the AIBL study of ageing. Alzheimer’s
Disease International, London, 8 March 2011
Ellis K, Lim YY, Ames D, Darby D, Harrington K,
Martins R, Masters C, Rowe C, Savage G, Szoeke
C, Villemagne V, Maruff P & AIBL Research Group.
AОІ amyloid, cognition and APOE genotype in the
preclinical stages of Alzheimer’s disease.
Rosemary Pace
Aged Care Standards and Accreditation Agency,
Better Practice 2013 Conference, Launceston
14–15 March 2013. Rosemary Pace and Danielle
Hariis, Resiential Services and Lifestyle Accreditation
Manger, �Speaking from the Heart’ session,
�Tranquility and Sports Garden’ presentation
Restrepo C, Saling M, Yates P, Villemagne V,
AmesВ D, Bush A, Faux N, Martins R, Masters
C, Rowe C, Szoeke C, Ellis K & AIBL Research
Group. The effects of vascular risk factors on
cognition in older adults: data from the AIBL study.
Alzheimer’s Association International Conference
2012, Vancouver, Canada, 18 July 2012 (presented
byВ CВ Restrepo)
Ageing: issues, trends and technological challenges.
RMIT University Platform Technologies Research
Institute Planning Day – 2012 and Beyond,
PortВ Melbourne, 6 September 2012
Will we be able to detect and treat pre-clinical
Alzheimer’s disease? The role of the AIBL study.
National Ageing Research Institute 3rd Annual
Seminar: Mental health and Ageing, Melbourne
7В September 2012
Rates of conversion in the AIBL cohort over
36В months. International Psychogeriatric
AssociationВ International Meeting 2012, Cairns,
9В September 2012
AIBL study 2012 update. AIBL Consumer Event,
University of Melbourne, 18 October 2012
Practical aspects of treating the elderly patient.
Everyday Practical Psychiatry, Barossa Valley, SA,
27В October 2012
Lampe L, Ames D, Castle D, Rampono J &
Hopwood M. Panel discussion. Everyday Practical
Psychiatry, Barossa Valley, SA, 28 October 2012
Ames D & Ellis K. AIBL introduction. CRC and
AIBLВ Research Conference, Melbourne Brain Centre,
26 November 2012
st vincent’s research report 2012
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Allied Health
Nutrition
The Nutrition Department at St Vincent’s
actively participates in research to improve
theВ identification and management of nutritional
issues impacting on the recovery of patients
andВ the management of chronic disease.
About us
The St Vincent’s Nutrition Department was
established in 1933 through the efforts of
GertrudeВ Healy, the Mother Rectress, and
celebratedВ its 75th anniversary in 2008. The
department provides nutrition and dietetics
services to all sites of St Vincent’s and aims
toВ fosterВ collaborative efforts, professional
excellence, nutritional research,В evidence-based
practice and professional development.
Major projects
The Nutrition Department was involved in the
Department of Health study investigating practices
related to Malnutrition in Victorian Cancer Services.
St Vincent’s was one of 15 sites involved. The point
prevalence of malnutrition across all sites was 31%.
At St Vincent’s the level was higher at 46%, with the
highest levels seen in the Upper Gastrointestinal,
Colorectal and Haematology units. The high
prevalence at St Vincent’s was thought to be due
to our patient population not including radiotherapy
patients which were identified to have a lower
level of malnutrition at other sites. At St Vincent’s,
dietitians were involved with 76% of patients with
malnutrition compared to the state average of 56%
(range 25–85%). Improvements are underway to
further optimise our identification and documentation
of malnourished patients.
The Nutrition Department commenced two new
research projects in 2012. The first involved a
collaborative project with the Physiotherapy and
Occupational Therapy departments to investigate
the relationship between nutritional status and
functional outcomes of patients on the Geriatric
Evaluation and Management unit. Data collection
continues into 2013. The second study collaborated
with the Orthopaedic Unit to investigate if patients
receiving pre and post-operative dietetic weight loss
advice have positive outcomes on pain, function
and quality of life measures after 12 months. Data
collection continues on these two research studies.
Quality
The Nutrition Department is continuing to drive
quality improvement initiatives in conjunction with
the hospital-wide St Vincent’s Nutrition Project
Working Group. The committee aims to raise
awareness of the importance of identifying patients’
nutritional problems on admission / point of entry,
and providing patients with adequate nutrition
during their hospital stay / treatment. The committee
has continued extensive staff education (medical,
nursing and support staff) as well as supported
the development of a new improved menu and
improving processes to the ensure patients
whoВ need assistance with their meals receive it.
TheВ Nutrition Department Dietitians undertook
anВ internal training program in a validated nutrition
assessment tool and reviewed documentation
toolsВ and processes in line with the International
Dietetics andВ Nutrition Terminology.
The Nutrition Department worked with the Intensive
Care Unit to disseminate the findings of the
International Nutrition Survey completed in 2011.
This study identified that since participating in 2008
we have improved performance across all indicators.
st vincent’s research report 2012
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Allied Health – Nutrition
Nutrition
Staff
Natalie Simmance, co-Chief Dietitian
Elizabeth Doyle, Acting Chief Dietitian
Clara Newsome, Grade 4 Dietitian
Anna Whitley, Senior Dietitian
Naomi Gandler, Dietitian
Katherine Kidd, Dietitian
Grants
Natalie Simmance
Nutritional Status of Older Hospitalised Patients
andВ associations with short and long term functional
outcomes, St Vincent’s
$14,869 for 1 year ($5,600 in 2012)
Natalie Simmance
A pilot study investigating dietetic weight loss
interventions and 12 month functional outcomes
of patients undergoing knee or hip surgery in
the elective surgery access service, St Vincent’s
$22,907 for 1 year ($7,242 in 2012)
Collaborations in research
• Monash University, Clayton, Victoria
Publications
Speaking engagements
Kidd K. International Nutrition Survey 2011 –
St Vincent’s Hospital Melbourne Site Report:
HowВ well are we feeding our patients in our intensive
care unit? St Vincent’s Research Week Moderated
Oral Poster Presentation, Melbourne, August 2012.
st vincent’s research report 2012
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Allied Health – Occupational Therapy
Occupational Therapy
The Occupational therapy department at
St Vincent’s actively participates in a variety
ofВ research initiatives. Our aim is to identify
andВ manage the diverse range of challenges
that face individuals on a daily basis with
anВ emphasis on evidence based practice.
About us
The St Vincent’s Occupational Therapy Department
provides a comprehensive service across the acute
and subacute streams of the hospital meeting
the needs of individuals at different stages in
theВ wellness continuum.
Occupational therapy is a profession concerned
with promoting health and wellbeing through our
engagement in occupation. Our research focuses
onВ improving the overall occupational performance
of our clients as they engage in their Activities of
daily living and as they interact daily with others
andВ their environment.
Our focus has included the factors shaping recover
post-stroke when returning to the community,
and the significant role that OT has in leading the
reduction in pressure care risks and pressure injuries
in patients in surgery suites and during their inpatient
stay. Ongoing work is being undertaken by the
Hand therapy department regarding the functional
outcomes of Australia’s first Hand transplant.
Major projects
Factors shaping the concept of recovery poststroke: Survivor and care perspectives
This study was designed to explore the concept
ofВ recovery from the perspectives of stroke survivors
and informal carers. The aim of this qualitative study
was to identify the main factors that are perceived
to contribute to recovery after stroke. It concluded
that community-based care should adopt targeted
interventions that concurrently consider stroke
survivor and carer’s individual concepts of recovery.
Data collection was completed for a research
project investigating the contextual influences
onВ ADL performance of older people with cognitive
impairment post-stroke & TBI. This data analysis
isВ currently being completed with OTs from
UniversityВ of Sydney and Charles Sturt University.
Quality
Alongside the implementation of National Safety
and Quality Health Service (NSQHS) Standards,
increased access to, and collaboration of the
role ofВ OTs in pressure care was required. This
necessitated OT staff training in specialist skills,
highlighting OT’s role, and improved efficiency
in referral processes. An OT pressure care
competency-based training package was developed
and delivered across 3 hospital sites to both allied
health and nursing. Utilising OT’s representation
on STV’s Skin integrity project working party
and COAG LSOP, the request for over 550
preventative pressure cushions for inpatient wards
was requested, and accompanying hospital-wide
staffВ education is planned for 2013.
Highlighting the outcomes of a project undertaken
toВ complete the Diploma of Management in 2012,
staff developed and implemented a new surgical
form to document pressure care assessment,
intervention and handover in operation suites
toВ target early risks for pressure care injuries.
st vincent’s research report 2012
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Allied Health – Physiotherapy
Staff
Collaborations in research
Danielle Sansonetti, Clinical Leader –
OccupationalВ therapist
• Bond University, Queensland Australia
Katie Anjou, Clinical leader – Hand therapist
Publications
Amber O’Brien & Courtney Agland, Grade 2
Occupational therapist’s Acute stream
Books
Students
Jo Garvie, Masters Health Administration
LatrobeВ University
Amber O’Brien, Masters Art therapy
Danielle Sansonetti Book review: Occupational
therapy interventions: Function and Occupations.
Catherine Meriano, JD, MHS, OTR/L: Donna Letella,
EdD, OTR/L.
Journal articles
Courtney Agland, Diploma of Management
Christine Graven, Danielle Sansonetti, Natasha
Moloczij, Dominique Cadilhac, Lynette Joubert.
Stroke survivor and carer perspectives of the
concept of recovery: a qualitative study. Disability
Rehabilitation April 2013, Vol. 35, No. 7, 578-585 (d
oi:10.3109/09638288.2012.703755)
Service to the wider community
Speaking engagements
• Rebekah Boffa, Senate Community Affairs
Reference Committee; Inquiry into Palliative care
in Australia (representing Australian Occupational
Therapy Association)
Sansonetti, D. Contextual influences on ADL
performance of older people with cognitive
impairment post-stroke and TBI. Stroke Society
Conference of Australia.
Theses passed in 2012
Amber O’Brien, Diploma of Management
• Nicholle Burns, Chairperson OT
VicВ 2012В Conference
• Nicholle Burns & Jo Garvie, External advisory
Committee for Australian Catholic University
Occupational therapy curriculum
Sansonetti, D. Post-discharge services for stroke:
consumer and carer perspectives. World Congress
for Neuro rehabilitation.
O’Brien, Amber & Agland, Courtney.
TakingВ theВ pressure off surgical patients.
OTВ VicВ StateВ conference.
st vincent’s research report 2012
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Allied Health
Physiotherapy
St Vincent’s Physiotherapy Department is a leader
in developing clinician-led research programs
forВ a range of conditions including stroke, multiple
sclerosis, back pain and orthopaedic joint
replacements. New directions in research include
primary contact physiotherapists in emergency
and development of simulation training programs
in critical care.
About us
St Vincent’s Physiotherapy Department provides
physiotherapy interventions across a spectrum of
acute and subacute services, inclusive of inpatient
physiotherapy services at St. George’s Hospital.
The department is a clinical teaching school for
the School of Physiotherapy, the University of
Melbourne, providing high quality undergraduate
andВ postgraduate education in both clinical and
research studies. The goals of research in the
Physiotherapy Department are to contribute to
theВ development of evidence-based physiotherapy
practice and to encourage a strong clinical focus
in physiotherapy research. The department has
aВ broad research agenda, including clinical trials
of treatment efficacy, development of assessment
protocols and health service evaluation. The research
scope in the Physiotherapy Department has grown
in recent years and we now have active research
projects inВ each of the key fields ofВ physiotherapy
practiced at St Vincent’s Hospital, inclusive of
musculoskeletal, neurological and cardiorespiratory
physiotherapy. The Department has also been
successful in encouraging young physiotherapists
to consider engaging in research and taking up
research postgraduate training. As well as having
programs of research specific to the discipline
ofВ physiotherapy, we are partners in collaborative
research projects with the departments of
Orthopaedics, Rehabilitation, Geriatric Evaluation
and Management and Emergency.
Major projects
The development of professional level courses
to raise the skill level of physiotherapists working
with high acuity patients is an important pathway
to improving clinical care in the intensive care
setting. Often there is limited opportunity for
hands-on practice in the hospital environment
either as students or as newly practising therapists,
particularly in rural and regional settings. The
cardiorespiratory team’s collaboration with the
St Vincent’s Simulation Centre over the last 3 years
has enabled the development of simulation-based
training for new graduate physiotherapists and
enhanced safety and effectiveness in our critical
care services. The Department has a focus on
investigating physiotherapy practice in expanded
scope roles. This includes physiotherapists providing
a triage service for referrals to Neurosurgery for back
pain and reviewing outcomes post joint replacement
surgery. In rehabilitation, trials are being conducted
in the different phases of recovery post stroke,
from patients at the very early stages post stroke
toВ community based interventions assisting patients
to achieve their own personal goals in the first year
after stroke.
Quality
The simulation based training program for critical
care has been a two-day course now offered to both
staff of St Vincent’s and external physiotherapists.
This is the first high-fidelity simulation course to run
in Victoria and early evaluation has shown that the
confidence and skills of participants has been greatly
enhanced by participation in the course.
In stroke care, the St Vincent’s Physiotherapy
Department has played the lead role in the
development of a Chronic Stroke Resource Kit,
auspiced by the Victorian Clinical Stroke Network.
The purpose of this kit is to provide community
rehabilitation clinicians with evidence based
assessment and intervention guidelines to enhance
outcomes for people with chronic stroke and their
carers. The key focus of the kit is on assisting stroke
survivors and their carers to achieve their own
personal goals. The research conducted by our
department in the first year after stroke informed
theВ direction and framework of the kit.
st vincent’s research report 2012
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Allied Health
Physiotherapy
Staff
Kim Brock, Grade 4 Physiotherapist/Research
Co-ordinator 0.25EFT
Robert Mehan, Grade 4 Physiotherapist,
ResearchВ 0.3 EFT
Melissa Thompson, Grade 3 Physiotherapist,
Research 0.4EFT
Susie Black, Grade 3 Physiotherapist,
ResearchВ 0.4EFT
Students
Christine Graven, PhD Student
Robert Mehan, Masters by Research, Student
Theses passed in 2012
Robert Mehan, Master of Exercise Science
(Research), Australian Catholic University
Service to the wider community
• Kim Brock, Member of Executive Committee,
International Bobath Instructor Training
Association, The Netherlands
• Cindy van Aswegen, Member Victorian Medical
Postgraduate Foundation
• Christine Frith, Member of Professional Practice
Standards Committee for Musculoskeletal
Physiotherapy Australia
Grants
Belinda Cary, Daniel Seller, Cindy Joffe
The development and implementation of a critical
care patient management course for physiotherapis
ts utilising high-fidelity simulation, APA Pat Cosh
Trust Fund
$18,715 for 2012
Cindy Joffe, Daniel Seller, Anthony Tobin,
KateВ McCarthy, Karen Kicker, Jacinta Schlitz,
Sherie Scott, Tamsin West, Belinda Cary
Development and Evaluation of Multi-disciplinary
Tracheostomy Education using High-Fidelity
Simulation Scenarios, Research Endowment Fund,
St Vincent’s
$13,500 for 2012
Simondson D, Thien C
Physiotherapy Led Clinics in Neurosurgery: A role
substitution model for triaging referrals for Low Back
Pain and Sciatica? St Vincent’s Hospital Research
Endowment Fund
$11,294 for 2011–2012 ($5,000 in 2012)
Jane Higgs, Professor Peter Choong,
SoniaВ Fankhauser, Karella De Jongh,
BelindaВ Cary, Stefan Wigg, Sonia Posenelli,
KimВ Brock, Sophie Rodier, Rachel Zacharakis.
The use of dedicated interpreter services for postoperative care following total knee replacement:
A randomized controlled trial, St Vincent’s Hospital
Research Endowment Fund
$14,884 for 2011–2012 ($7,400 in 2012)
Paul Ilett, Kim Brock, Dr. Ross Clark (Melb Uni),
Melissa Thompson, Janine Simondson, Rob
Mehan, Dr Irina Churilov
What is the relationship between improvement
inВ gait and balance ability and changes in symmetry
between the hemiplegic and nonhemiplegic
lower limb in the recovery phase post stroke?,
St. Vincent’s Hospital Research Endowment Fund
$11,498 for 2011–2012 ($2,000 in 2012)
Kim Brock, Chris Graven, Melissa Thompson,
Dominique Cadilhac, Tara Purvis
Chronic Stroke Resource Kit, Victorian Stroke
Clinical Network, Department of Health, Victoria
$17,000 for 2012–2013 ($4,000 in 2012)
Brock K, Luke C, Galea M, Miller K
Improving outcomes for the upper limb in severe
stroke: the efficacy of rehabilitation interventions
based on the Bobath Concept, National Stroke
Foundation
$20,000 for 2010–2013 ($5,000 in 2012)
Cindy Joffe, Bridget Shaw, Tom Collins
&В BelindaВ Cary
Expanded Scope of Practice for Physiotherapists
in the Emergency Department – Implementation Site,
Health Workforce Australia
$345,000 for 2012–2013 ($193,000 in 2012)
st vincent’s research report 2012
26
Allied Health
Physiotherapy
Collaborations in research
Speaking engagements
National
Robert Mehan. A preliminary study into the use
of ankle foot orthosis in the early stages of stroke
recovery. World Congress for NeuroRehabilitation,
Melbourne, May 2012
• University of Melbourne, Parkville, Victoria
• Monash University, Clayton, Victoria
• Curtin University, Perth, Western Australia
• La Trobe University, Bundoora, Melbourne
• Australian Catholic University, Fitzroy, Melbourne
• Florey Neuroscience Institutes, Heidelberg,
Melbourne
• Western Health, Sunshine, Victoria
• Cairns Base Hospital, Cairns, Queensland
• Alfred Health, Melbourne, Victoria
• Ballarat Base Hospital, Ballarat, Victoria
• Health Workforce Australia, Canberra, Australia
Publications
Christine Graven. Factors shaping the concept of
recovery post-stroke. Smart Strokes Conference,
Sydney, August 2012
Daniel Seller. Does high-fidelity simulation training
improve self-confidence of junior physiotherapists
performing ICU clinical skills? SimHealth, Sydney,
Sept 2012
Daniel Seller. Does high-fidelity simulation training
improve self-confidence of junior physiotherapists
performing ICU clinical skills? Australian and New
Zealand Intensive Care Society (ANZICS), Adelaide,
Oct 2012
Journal articles
Kennedy GM, Brock KA, Lunt AW, Black SJ. (2012).
Factors influencing selection for rehabilitation after
stroke: A questionnaire using case scenarios to
investigate physician perspectives and level of
agreement. Arch Phys Med Rehabil 93(8):1457–9
Simondson D, Brock K, Cotton S. (2012). Reliability
and smallest real difference of the ankle lunge test
post ankle fracture. Manual Therapy 17: 34–38.
st vincent’s research report 2012
27
Allied Health
Prosthetics andВ Orthotics
St Vincent’s Prosthetic and Orthotic department
aim to further the knowledge base of the
profession and improve patient outcomes through
the development and investigation ofВ innovative
management and manufacturing techniques.
About us
The Prosthetic and Orthotic department manufacture
custom made devices to assist patient function.
Research therefore focuses on three areas:
• Innovative designs to increase function
andВ improve cosmesis
• Minimising weight and maximising strength
andВ durability through the use of new materials
and manufacturing methods
• Evaluating the impact of treatment in relation
toВ patient outcomes
st vincent’s research report 2012
28
Allied Health
Social Work
Social Work and the Aboriginal Hospital
Liaison Officer Program strive for excellence
and innovation in the provision of services to
patients and their families, in teaching, research
and collaborative partnerships. Research is
anВ important part of the work we do, as well
asВ informing clinical care.
About us
Our research is driven by the values of excellence,
social justice and compassion. We are committed
to improving care for consumers by address gaps
inВ health care that impact patients. Our focus is to
both build knowledge and translate this into practice.
Importantly, our research efforts are characterised
byВ collaboration both internally and externally.
During 2012 we progressed research in relation to
Aboriginal health, adjustment to cancer, elder abuse,
underserved populations including rural patients,
patterns of care for homeless patients and the
unmet needs of asylum seekers.
The Australian Research Council funded study From
suspicion to intervention: improving responsiveness
to abuse of the elderly presenting to a hospital
setting is in its final year.
Better understanding and responsiveness to the
supportive care needs of cancer patients remains
aВ key priority area. The needs of diverse and
underserved cancer populations are featuring
inВ ourВ research efforts. For example, a new Western
&В Central Melbourne Integrated Cancer Service
(WCMICS) grant is enabling us, in collaboration
withВ the Cancer Council Victoria, to implement
andВ evaluate a telephone intervention for
regionalВ Victorians and those in treatment
atВ STVВ satellite centres.
We partnered with St Vincent’s Mission/Aboriginal
Health on several innovative translational research
projects, to implement national research findings
onВ improving hospital culture and responsiveness
toВ Aboriginal and Torres Strait Islander people,
through a Continuous Quality Improvement approach.
A key initiative this year focussing the social
determinants of health was the Asylum Seeker
Scoping Study 2012, funded through the
St Vincent’s Health Australia’s (SVHA) Social
JusticeВ Strategy.
Major projects
The findings of the Asylum Seeker Scoping Study
have the potential to inform SVHA regarding future
directions in advocacy and policy development,
in a critical area of social justice and health care.
The diverse collaboration involving the Emergency
Practice Innovation (EPI) Centre Melbourne and
theВ Brotherhood of St Laurence was a highlight.
In Aboriginal Cardiac Care Amanda (Mandy) Punch,
Aboriginal Hospital Liaison Officer, completed her
involvement in a research project which trialled an
AHLO and nurse-led model of care for Aboriginal
and Torres Strait Islander patients presenting
to St Vincent’s for management of myocardial
infarction. Led by the Australian Catholic University’s
St Vincent’s Centre for Nursing Research,
theВ research was funded by the Department
ofВ Health Victoria and was supported by the Heart
Foundation. At St Vincent’s Research Week 2012
Ms Punch presented on the findings of the project
and received an oral research presentation award.
We completed and evaluated an innovative Social
Work Leadership and Mentoring Project. The
findings and outcomes informed a submission which
won a 2012 SVHA Quality Award – Remarkable
People: Nurturing the Talents of Our People.
Quality
The project From Suspicion to Intervention has led
to the development, trial and evaluation of hospital
focussed educational DVDs on elder abuse and an
educational package. This work also informed the
development of a new model of care, governance
arrangements and policy for STV on the Protection
of Vulnerable Older People (formally ratified in
MarchВ 2013).
Our three-year Clinical Rotations Workforce Australia
Project with the Department of Social Work, The
University of Melbourne is in its second year. Across
five participating hospitals the findings to date have
highlighted the different needs of the university
versus the workforce in relation to fieldwork
teaching. Early results are positive on several key
parameters including student satisfaction and the
�work readiness’ of students trained under the new
model.
st vincent’s research report 2012
29
Allied Health
Social Work
For Social Work in Cancer Services developments
undertaken in 2012 will enable us to implement a
Wellbeing/Psycho-education Program for patients
with cancer, their families and carers. Work this year
included protocol development, the preparation of
manuals for sessions on �Treatment Completion’ and
�New Patients and Carers’ and training of facilitators.
This work was made possible by Marathon of the
Sands Fundraising.
Staff
Carrie Lethborg, Co-ordinator Psychosocial Cancer
Research, 0.4 EFT
Meghan O’Brien, PhD Student, 0.4 EFT
Sonia Posenelli, Chief Social Worker/Project
Coordinator (to September 2012), 0.4 EFT
Amanda Punch, Research Assistant
(toВ SeptemberВ 2012), 0.4 EFT
Rosie Brown, Research Assistant, 0.4 EFT
Bridie Egan, Research Assistant
(fromВ AprilВ 2012),В 0.2 EFT
Pauley Kessel, Research Assistant
(fromВ JulyВ 2012),В 0.2 EFT
Nicole Tokatlian, Research Assistant
(fromВ September 2012), 0.1 EFT
Melinda Collins, Research Assistant,(for the month
ofВ September 2012), 0.2 EFT
Students
Meghan O’Brien, PhD, The University of Melbourne
Katie Carlson, Masters of Social Work,
MonashВ University
Lisa Braddy, Masters of Social Work,
MonashВ University
Service to the wider community
Dr Carrie Lethborg
• Executive Member – Victorian Co-operative
Oncology Group (VCOG) Executive,
(FirstВ non-medical member appointed)
• Invited Member – Clinical Management Advisory
Team – Western and Central Melbourne Integrated
Cancer Services (WCMICS)
• Invited Member – DOH Victoria,
CancerВ Survivorship Steering Committee
• Executive Member –
OncologyВ SocialВ WorkВ Australia (OSWA)
• Executive Member – Cancer Social Work Victoria
• Invited Member – Department of Health Victoria,
Supportive Care Evaluation Expert Reference Group
• Editorial Board Member
(TheВ JournalВ ofВ PalliativeВ and Supportive Care)
• Peer Reviewer – Psycho-oncology,
TheВ JournalВ ofВ Psychosocial Oncology,
TheВ Journal of Palliative and Supportive Care
• Ph D confirmation panel – Deakin University
(Psychology)
• Ph D confirmation assessor –
UniversityВ ofВ Melbourne (Medicine)
• Assessor (Master in Psychology –
Monash University, Social Work Masters –
Flinders University, PhD – Monash University)
• Honorary Post-Doctoral Fellow
(PeterВ MacВ CallumВ Cancer Centre
andВ UniversityВ of Melbourne)
Grants
Hadgkiss E, Lethborg, Al-Mousa A, Marck C
Scoping Study into Asylum Seeker Health and
Wellbeing (Medicare ineligible community residing
asylum seekers), St Vincent’s Health Australia
$16,390 for 2012
Egan B, Lethborg C, Moss D, Posenelli S,
McKeever U
Patients with No Fixed Address: Analysing length
ofВ stay, discharge pathways and continuity of care
of homeless patients admitted to St Vincent’s Hospital,
St Vincent’s Hospital Melbourne
$16,195 for 2013 (Nil in 2012)
Lethborg C (Principal Investigator), Brown R,
Snyder R, Kessel P, Posenelli S, Dunn W, Packer
C, Smith L, Horden A
The development of a sustainable model to provide
brief supportive care interventions to underserved
cancer patients, Western and Central Melbourne
Integrated Cancer Services
$89,971.72 for 2012–2013 ($45,000 in 2012)
• Chair – Supportive Care Advisory Committee –
WCMICS
st vincent’s research report 2012
30
Allied Health
Social Work
Collaborations in research
Publications
• Emergency Practice Innovation Centre, Melbourne
Book chapters
• Ecumenical Migration Centre,
BrotherhoodВ ofВ StВ Laurence, Melbourne
Kissane DW, Lethborg CE, Kelly B. 2012. Spiritual
and Religious Coping with Cancer, In L Grassi
and M Riba (eds), Clinical Psycho-Oncology: An
International Perspective, London, Wiley-Blackwell
(Pp 281–296), ISBN: 978–0–470–97432–2
• Centre for Palliative Care and Education, Melbourne
• Peter Mac Callum Cancer Centre
• Werribee Mercy Hospital
• Goulburn Valley Health
• St Vincent’s Health Australia
• Aboriginal Health Branch,
DepartmentВ ofВ HealthВ Victoria
• St Vincent’s Centre for Nursing Research,
Australian Catholic University
• New South Wales Health
• Onemda VicHealth Koori Health Unit
• Western & Central Melbourne Integrated
CancerВ Service
• Northern Health
• Western Health
• Department of Social Work,
TheВ UniversityВ ofВ Melbourne
• Social Work, Melbourne Health
• Social Work, Royal Children’s Hospital
• Social Work, Austin Health
• Social Work, Western Health
Journal articles
Lethborg C, Schofield P, Kissane D (2012), The
patient experience of undertaking Meaning and
Purpose �MaP’ Therapy in the setting of advanced
cancer, Palliative and Supportive Care. 4(10)
Moore G, Collins A, Brand C, Gold M, Lethborg C,
Murphy M, Sundararajan V, Philip J (2012) Palliative
and supportive care needs of patients with highgrade glioma and their carers: A systematic review
of qualitative literature, Patient Education and
Counselling, December 4.
Nilsson D, Joubert L, Holland L, Posenelli, S (2013),
The Why of Practice: Utilizing PIE to Analyze Social
Work Practice in Australian Hospitals, Social Work
in Health Care Volume 52, Issue 2–3.
Conference publications
Understanding the Supportive and Palliative Care
Needs of Patients with Primary Malignant Glioma:
Views of Carers and Health Care Professionals,
Philip, J., Collins, A., Brand, C., Gold, M., Moore,
G., Sundararajan, V., Murphy, M., and Lethborg,
C, World Research Congress of the European
Association of Palliative Care (EAPC), Trondheim
7–9 June 2012 (Oral Presentation).
Understanding the Supportive and Palliative Care
Needs of People with Primary Malignant Glioma
and their Carers, Philip, J., Gold, M., Brand, C.,
Lethborg, C., Murphy, M., Sundararajan, V., Moore,
G., Collins, Shaping the Future of Palliative Care
Conference, Palliative Care Victoria, Melbourne,
23–24 August 2012 (Oral Presentation).
Utilising Hospital Administrative Datasets to Identify
Patterns of Service Use in Patients with a Primary
Malignant Glioma, Collins, A., Philip, J., Brand, C.,
Gold, M., Bohensky, M., Lethborg, C., Murphy, M.,
Moore, G., and Sundararajan, V, 19th International
Congress of Palliative Care, Montreal, 9–12 October,
2012 (Oral Presentation).
Utilising Hospital Administrative Datasets to Identify
st vincent’s research report 2012
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Allied Health
Social Work
Patterns of Service Use in Patients with a Primary
Malignant Glioma, Philip, J., Brand, C., Gold, M.,
Bohensky, M., Lethborg, C., Murphy, M., Moore,
G., Collins, A., and Sundararajan, V. The IPOS
14th World Congress and Psychosocial Academy,
Brisbane, Australia, 11–15 November 2012
(OralВ Presentation).
Understanding the Supportive and Palliative Care
Needs of People with Primary Malignant Glioma
and Their Carers, Philip, J., Collins, A., Brand, C.,
Gold, M., Murphy, M., Moore, G., Sundararajan, V.,
and Lethborg, C, The IPOS 14th World Congress
and Psychosocial Academy, Brisbane, Australia,
11–15 November 2012 (Oral Presentation).
Speaking engagements
Braddy L, Clinical Supervision, Invited presentation,
Social Work Dandenong Hospital, November 2012.
Kallianis V, Anastasia – Greek Support Group,
STVВ Research Week, August 2013
Lethborg C, The underserved cancer patient,
InvitedВ presentation, Social Work Day,
WesternВ Health, March 2012
Lethborg C, Identifying the underserved groups
in cancer care – core to the social work role – Invited
presentation, Social Work Day, St Vincent’s Hospital,
March 2012
Lethborg C, The Social Determinants of Health
–Cancer, COSA/IPOS Invited Plenary, Brisbane,
November 2012
Lethborg C, Posenelli S, Brock K, Chapman P,
Nandurkar H, STV Research Week Hypothetical,
St Vincent’s Hospital May 2012
Winters M, and Posenelli S, Culturally Respectful
Social Work Practice with Aboriginal People.
Aboriginal Health is Everybody’s Responsibility,
Department of Health Victoria, May 2012
(OralВ Presentation)
Lethborg C, Treatment completion, Invited
Presentation for Breast Cancer Network Australia,
remote patient scheme – Cairns, May 2012
Lethborg C, �MaP Therapy’ – Invited Presentation,
Social Work Department – Cairns Base Hospital,
May 2012
Lethborg C, Meaning and Suffering – Exploration
Towards The Meaning Of Life, Invited Presentation,
CafГ© Church, Baden Powell Hotel, Collingwood,
MayВ 2012
Lethborg C, “Supporting blokes” – issues for
partners of women with breast cancer, Invited
Presentation, �Think Pink’ – The Living Centre,
Melbourne, August 2012
Lethborg C, “Map Therapy” – Invited Presentation,
Eastern Palliative Care, Victoria, November 2012
st vincent’s research report 2012
32
Anaesthetics
The St Vincent’s Department of Anaesthesia
is at the forefront of clinical research in a
wide range of studies aimed at improving the
clinical delivery and outcomes in the field of
anaesthesia, perioperative medicine and pain
management.
About us
Dr Michael Barrington has continued to excel in
his studies of regional anaesthesia. His data ase
now includes well over 35,000 cases of regional
anaesthesia making it the world’s leading data base
inВ this field.
The Centre for Anaesthesia and Cognitive Function
continues to expand knowledge in the field of
postoperative decline. Chief Scientist Lisbeth
Evered was instrumental in establishing the
professional interest area at the Alzheimer’s
Association International Conference in Vancouver,
which sheВ convened and chaired. This meeting
attracted a large international audience to focus on
research surrounding the cognitive changes related
toВ anaesthesia.
A unique aspect of the Anaesthetic Department
is the many individual members who pursue
specific research interests encompassing a wide
range of clinical subspecialties. Areas of research
include fluid balance, pain management, cardiac
echocardiography, anaesthetic simulation,
processed electroencephalography and risk
management.
Lisbeth Evered was at the forefront of international
meetings on cognitive function and anaesthesia.
She was a key organiser at the World Congress of
Anaesthesia in Buenos Aries and later in the year at
the Alzheimer’s Association International Conference.
Brian Cowie has published widely in international
journals on the utility of echocardiography in the
operating theatre.
Brendan Silbert received the Harry Daly Research
Award for ANZCA Research Grant, entitled Long Term
Anaesthesia Cognition Evaluation (LOTACE) Study.
Ongoing Projects in 2012
• Ultrasound aided placement of IV central lines –
AВ Stewart, D Scott
• Propofol cardio protection for diabetic patients
during C-P bypass (PROSEV) – R Kluger,
DВ McGlade
• IV lignocaine analgesia in laparoscopic bowel
surgery (LIVABLES) – C. Scarff
• Femoral Nerve catheter versus intra-articular
anaesthetic surgical infiltration for total knee
jointВ replacement - D Olive
• Aspirin and tranexamic acid in coronary artery
surgery trial (ATACAS) – B Silbert, S Said
• RESORT” study: Fluid restriction compared to
fluid optimisation with the oesophageal doppler
inВ major abdominal surgery: a randomized clinical
trial of efficacy – Tuong Phan
In addition, the St Vincent’s Anaesthetic department
is a key player in several large multinational studies
co-coordinated by the Australian and New Zealand
College of Anaesthetists Clinical Trials Group.
• The COMFORT study A comparison of three
techniques for analgesia following total knee
jointВ replacement: Continuous femoral nerve
block or spinal morphine or both – M Barrington
and D Olive
Major projects
• Brain Anaesthesia Response Monitoring System
(BAR study) – D McGlade, D Scott
In 2012, Michael Barrington expanded The
Australasian Registry of Regional Anaesthesia
to become the International Registry of Regional
Anaesthesia. This registry, based at St Vincent’s,
is now responsible for managing a multicentre
study involving 17 hospitals around the world. Not
surprisingly, Dr Barrington has been in demand
to present his data at a multitude of clinical
conferences (see below). Together with Roman
Kluger, Michael Barrington received the Best of
Science, Clinical Science Award at the Annual
American Society of Anesthesiologists Annual
Meeting 2012 in Washington.
QUALITY
With the International Registry of Regional
Anaesthesia now providing sound scientific data
onВ the safety of regional anaesthesia, there has been
a worldwide trend to exploit the benefits of regional
anaesthesia both intra and post operatively. This has
resulted in a major improvement in postoperative
pain relief and has been responsible for the improved
management of many patients undergoing surgery.
st vincent’s research report 2012
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Anaesthetics
The confluence of patients with cognitive impairment
who also undergo surgery is leading to a greater
part played by anaesthetists in the management
ofВ anaesthesia in this increasingly prominent elderly
group of patients. The Centre for Anaesthesia and
Cognitive Function has advocated that anaesthetists
closely track cognitive changes after anaesthesia in
the elderly. In the future, simple memory testing may
become a part of routine preoperative assessment
inВ the elderly.
The use of echocardiography for preoperative
assessment is now becoming possible based
onВ theВ learned articles published by Dr Cowie.
InВ theВ future, such assessments may play an
important role in decision-making in relation
toВ anaesthetic management.
Staff
Ms Lisbeth Evered, chief scientist, leads the Centre
for Anaesthesia and Cognitive Function. She
has been ably helped by assistant researchers
Sarah Maher and Sally Pritchard. Simone Said
isВ the anaesthetic research nurse who undertakes
andВ oversees the large number of clinical projects
withinВ the Department. She has been assisted
byВ nurses from the Pain Unit, Kim Choate and
Wendy McDonald.
Lauren Braam and Taryn Luitingh assisted Michael
Barrington with the Regional Anaesthesia Registry.
Finally, although the Department is a clinical
department with substantial clinical commitments,
theВ anaesthesia staff provides an outstanding
example of commitment to research. This is
evidenced by the number and quality of research
projects and publications which are exceptional
forВ a clinical Department limited dedicated
researchВ support.
Students
PhD: Michael Barrington; Lisbeth Evered
Masters Biostatistics: Roman Kluger;
PainВ Management, Andrew Stewart,
SERVICE TO THE WIDER COMMUNITY
• Members from the Department of Anaesthesia
play a dominant role in the Australian and
NewВ Zealand College of Anaesthetists. A/Prof
David Scott is a councillor, Rowan Thomas is
on the regional Victorian Committee, and Brian
Cowie and Roman Kluger are on the examination
committee. David Olive is on the executive of
the Australian Society of Anaesthetists. Michael
Barrington is Chair, Regional Anaesthesia Special
Interest Group of the Australian and New Zealand
College of Anaesthetists (ANZCA).
• Brendan Silbert is vice-chair of the St Vincent’s
Human Research Ethics Committee.
Grants
Silbert B, Scott DA, Evered L
Alzheimer’s disease processes, NHMRC
$157,187 for 1 year ($60,000 in 2012)
Silbert B, Scott DA, Evered L.
Long Term Anaesthesia Cognition Evaluation
(LOTACE) Study, The Australian and New Zealand
College of Anaesthetists
$120,000 for 2 years ($60,000 in 2012)
Barrington M
The Australian and New Zealand Registry
ofВ Regional Anaesthesia, The Australian
andВ NewВ Zealand College of Anaesthetists
$70,000 for 1 year ($70,000 in 2012)
Barrington M
The Australian and New Zealand Registry of
Regional Anaesthesia, Australia and New Zealand
Banking Group Limited, William Joseph Payne Trust
$13,000 for 1 year ($13,000 in 2012)
Dr Tuong Phan
RESORT study: Fluid restriction compared to fluid
optimisation with the oesophageal doppler in major
abdominal surgery: a randomized clinical trial of
efficacy, St Vincent’s Research Endowment Fund
$15,000 for 1 year ($15, 000 in 2012)
Grad Dip Aviation (Human Factors). Gaylene Heard
st vincent’s research report 2012
34
Anaesthetics
COLLABORATIONS IN RESEARCH
• Michael Barrington is Coordinator of The
International Registry of Regional Anaesthesia
• The Department is a key player in the Australian
and New Zealand College of Anaesthetists Clinical
Trials Group
• The Centre for Anaesthesia and Cognitive
Function is playing a key role with the Australian
Imaging Biomarker and Lifestyle Study
• Dr Des McGlade is collaborating with the Swinburne
University Neuroscience Research group
Publications
Book chapters
Phillipa Hore co-authored the New fifth edition
of Anaesthesia – An Introduction. Brochures are
available throughout the department and we will
beВ purchasing a number of copies for our HMOs.
Journal articles
Barrington MJ. International registries of regional
anesthesia: are we ready to collaborate in virtual
departments of anesthesiology? Reg Anesth Pain
Med. 2012 Sep-Oct; 37(5): 467–9.
Barrington MJ, Wong DM, et al.: Ultrasound-Guided
Regional Anesthesia: How Much Practice Do Novices
Require Before Achieving Competency inВ Ultrasound
Needle Visualization Using a Cadaver Model. Reg
Anesth Pain Med. 2012 May-Jun; 37(3): 334–9.
Koziol J, Gertler R, et al. The effect of intraoperative
hypotension on the outcomes of initial hybrid
palliation for single ventricle congenital heart disease:
an historical cohort study” in: Canadian Journal
of Anaesthesia May 2013, 60(5), 465–470.
Ng MD, Manikappa S Postpartum Seizure and
Ischaemic Stroke following Dural Puncture and
Epidural Blood Patch. Anaesthesia and Intensive
Care 2012; 40: 347–351.
Cowie BJ. Focused Transthoracic Echocardiography
Predicts Perioperative Cardiovascular Morbidity.
Cardiothorac Vasc Anesth. 2012 Aug 21. [Epub
ahead of print]
Cowie B, Kluger R, Kalpokas M. Left ventricular
volume and ejection fraction assessment with
transoesophageal echocardiography: 2D vs 3D
imaging. Br J Anaesth. 2012 Oct 3. [Epub ahead
ofВ print]
Cowie BJ, Corcoran P. Postanesthesia Care
Unit Discharge Delay for Nonclinical Reasons.
JВ PeriAnesthesia Nursing, 27, No 6 (December),
2012: pp 393–398.
Scott DA, Silbert BS, Evered LA. Anesthesia and
Alzheimer’s disease: time to wake up! International
Psychogeriatrics, Available on CJO doi:10.1017/
S1041610212001792.
Crowley C, Dowsey MM, Quinn C, Barrington
MJ, Choong PFM: Impact of regional and local
anaesthetics on length of stay in knee arthroplasty.
ANZ Journal of Surgery. 2012 April; 82(4): 207–214.
Cowlishaw PJ, Scott DM, Barrington MJ: The
role ofВ regional anaesthesia techniques in the
management of acute pain. Anaesth Intensive
Care 2012; Volume 40: 33–45.
Heard GC, Sanderson PM, Thomas RD. Barriers
to adverse event and error reporting in anesthesia.
Anesth Analg. 2012 Mar;114(3):604–14
st vincent’s research report 2012
35
Anaesthetics
Speaking engagements
Dr Tuong Phan
The Department has presented research at numerous
international, national and state venues. Some of the
more prominent presentations are listed below.
ANZCA ASM 2012 Perth PBLD – Cardiac Output
monitors and Goal Directed Therapy
Michael Barrington
Perioperative Neurotoxicity and the Elderly’ Satellite
Workshop, Buenos Aires
Thoracolumbar Nerve Blocks – Transabdominis plane,
Rectus sheath, and Ilioinguinal-Iliohypogastric Nerve
blocks: A Review of the Anatomy and Techniques.
Presented at The American Society of Regional
Anesthesia and Pain Medicine Spring Meeting,
SanВ Diego, USA
Epidemiology of Neurological Complications
of Regional Anaesthesia Clinical Registries –
Improving Quality and Safety by Proactively
Monitoring Outcomes. Presented at Naval
MedicalВ Center, SanВ Diego, USA
David Scott
The Art of Anaesthesia ANZCA/ASA Meeting
inВ Canberra
Bonica Lecture at the Australian Pain Society
AnnualВ Conference in Melbourne
Kim Choate
Australian College of Critical Care Nurses (ACCCN)
Annual Conference on Pain Control in ICU
Improving Quality and Safety by Proactively
Monitoring Outcomes. Dartmouth Hitchcock
MedicalВ Center, NH, USA
Incidence and Epidemiology of Neurologic
Complications of Regional Anesthesia.
Massachusetts General Hospital, Boston, USA
The Quality and Safety of Peripheral Regional
Anesthesia. Presented at Johns Hopkins Hospital,
Baltimore, USA
Lisbeth Evered
Combined Perioperative Medicine SIG
andВ AcuteВ Pain SIG meeting, Byron Bay
Perioperative Neurotoxicity and the Elderly’
WorldВ Congress on Anaesthesia, Buenos Aires
Brendan Silbert
Alzheimer’s Association International Conference
Vancouver Canada 2012: Professional Interest Area
(Anaesthesia, Cognition and Dementia) symposium
at Alzheimer’s Association International Conference
Vancouver Canada
Australian and New Zealand College of Anaesthetists
Annual Scientific Meeting Perth
National Dementia Research Forum, Canberra
st vincent’s research report 2012
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breastscreen
St Vincent’s BreastScreen (SVBS) is a multicentred breast cancer population screening
program which participates in clinical and
collaborative research aiming to investigate
breast cancer risk factors and improve breast
cancer detection and treatment.
ABOUT US
SVBS is a major screening and assessment service
ofВ BreastScreen Australia, a national program
aimingВ to reduce the mortality of breast cancer.
The aim of screening for breast cancer is to detect
malignancy at an early stage. This is associated
with a reduction in mortality from breast cancer
andВ reduced morbidity from treatment. SVBS
primary purpose is to detect early breast cancer
through a network of eight dedicated and accredited
screening services. All administrative, assessment
and audit functions are performed at the assessment
centre at St Vincent’s. We have research links
with The University of Melbourne Departments
ofВ Molecular, Environmental, Genetic and Analytic
Epidemiology and the Key Centre for Women’s
Health in Society, as well as St Vincent’s Medical
Imaging Department, St Vincent’s Institute and
PeterВ MacCallum CancerВ Institute.
QUALITY
The unit monitors performance against
172В NationalВ Accreditation Standards and actively
seeks opportunities to improve practice. The unit
underwent conversion to digital mammography
inВ late 2011. The use of this new technology brings
certain efficiencies and improvement to work flow
which improves service delivery.
STAFF
Dr Helen Frazer, Director
A/Prof Jennifer Cawson, Consulting Radiologist
Miss Caroline Baker, Surgeon
Miss Elaine Bevington, Surgeon
Mr David Butterfield, Surgeon
A/Prof Mr Hamish Ewing, Surgeon
Mr Patrick Hayes, Surgeon
Miss Jane O’Brien, Surgeon
A/Prof Michael Henderson, Surgeon
Miss Wanda Stelmach, Surgeon
Mr Anthony Hyett, Surgeon
Miss Cathie Poliness, Surgeon
MAJOR PROJECTS
Dr David Van Genderin, Radiologist
In 2012, 46,357 women were screened through
our network of seven urban and one rural screening
centre throughout Victoria. Assessment of possible
abnormalities through to diagnosis of cancer, was
performed at the assessment centre in the Healy
Wing of St Vincent’s Fitzroy campus. In 2012, 2,546
women underwent assessment and 270 new breast
cancers were detected.
Dr Kirsten Gordon, Radiologist
In July 2012 SVBS was awarded four years
accreditation which is a significant achievement.
A/Prof Cawson stepped down from the Director
position in April 2012 and is now a Consultant
Radiologist with Dr Helen Frazer taking up the
position as Clinical Director of BreastScreen.
Dr Greg Hill, Radiologist
Dr Henry Karsz, Radiologist
Dr Frank Malara, Radiologist
Dr Kirti Mehta, Radiologist
Dr Mei Pang, Radiologist
Dr Wendy Perret, Radiologist
Dr Gareth Phillips, Radiologist
Dr Hannah Rouse, Radiologist
Dr Bronwen Slater, Radiologist
Dr Rodney Taft, Radiologist
Dr Siricha Madhala, Fellow
Dr Simon Usher, Fellow
Dr Nicola Stephens, Fellow
Ms Erin Cosgriff, Program Manager
Ms Kerri Scallion, Data Manager
Mrs Louisa De Leonardis, Data Manager
st vincent’s research report 2012
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breastscreen
PUBLICATIONS
Journal articles
Ix Liang1, Kotogiri Ramamohanarao2, Helen Frazer3
and Qin Yang4, 1National ICT Australia, 2Department
of Computer Science and Software Engineering,
University of Melbourne, 3Department of Radiology,
St Vincent’s Hospital Melbourne, 4Apollo Medical
Imaging Technology Pty Ltd. A lesion shape and
margin characterisation method in dynamic contrast
enhanced magnetic resonance imaging of the breast
Ix Liang , Kotogiri Ramamohanarao , Helen Frazer
and Qin Yang4, 1National ICT Australia, 2Department
of Computer Science and Software Engineering,
University of Melbourne, 3Department of Radiology,
St Vincent’s Hospital Melbourne, 4Apollo Medical
Imaging Technology Pty Ltd. Lesion Segmentation
inВ Dynamic Contrast Enhanced MRI of Breast
1
2
3
Johnson C, Gorringe KL, Thompson ER, Opeskin
K, Boyle SE, Wang Y, Hill P, Mann B, Campbell IG.
Identification of copy number alterations associated
with the progression of DCIS to invasive ductal
carcinoma Br Cancer Res Treat 133: 889-98, 2012
Hugo HJ, Periera L, Suryadinata R, Drabsch Y,
Gonda TJ, Gunasinghe D, Pinto C, Hill P, Ramsay
RG, Sarcevic B, Newgreen DF, Thompson EW.
Direct repression of MYB by ZEB1 suppresses
proliferation and epithelial gene expression during
epithelial-to-mesenchymal transition of breast cancer
cells. Br Cancer Res (submitted)
Conferences attended/ Speaking engagements
Dr Helen Frazer
European Breast Cancer Conference, March 2012
International Breast Update 2012: Future Directions,
April 2012
Breast Conference, October 2012
A/Prof Jennifer Cawson
European Breast Cancer Conference, March 2012
International Breast Update 2012: Future Directions,
April 2012
Asian Oceania Society of Radiology, Sydney,
September 2012
Nguyen BT, Deb S, Fox S, Hill P, Collins M, ChuaВ B:
A prospective pathologic study to define the clinical
target volume for partial breast radiotherapy in
women with early breast cancer. Int J Rad Onc
BiolВ Phys 84: 1116-22, 2012
Chew GL, Huang D, Lin J, Huo C, Blick T,
Henderson MA, Hill P, Cawson J, Morrison
W, Campbell I, Hopper J, Southey M, Haviv
I, Thompson EW. Maintenance of high and
low mammographic density human breast
tissue inВ murine tissue engineering chambers,
BrВ CancerВ ResВ Treat 135: 177-87, 2012
Chew GL, Huang D, Huo C, Blick T, Hill P,
CawsonВ J, Frazer H, Southey M, Hopper J,
Henderson M, Haviv I, Thompson E. Effect
of murineВ peripartum states on high and low
mammographic density human breast tissues
maintained in murine tissue engineering chambers.
BrВ Cancer Res Treat (submitted)
st vincent’s research report 2012
38
Cardiothoracics
The Department of Cardiothoracic Surgery
divides research into two cells with shared
research coordinators. The Cardiac Surgery cell
is researching the effects of a new paradigm
of aortic stenting and is leading the way in
performing sutureless aortic valve replacement
surgery. We are also interested in obtaining
population-based outcomes data for surgical
procedures. The Thoracic cell develops and
studies minimally invasive surgical techniques
and performs clinical and translational research
in lung cancer.
About us
The Cardiac Surgery cell is a leader in developing
and introducing new techniques to treat aortic
aneurysm and aortic dissection with expandable
artificial blood vessels (stents). Research is also
conducted into heart failure surgeries, including remodeling of the heart, implantation of devices and
new generation heart valves. We are also constantly
striving to improve the patient experience during and
after surgery with multiple projects aimed at ensuring
the care that is given is the most appropriate. We
are investigating the outcomes of various cardiac
surgery procedures by combining our results with
those of the Australian Cardiac Surgery database
toВ get an overall view of the problems that occur
as a result of this surgery, in an attempt to guide
potential improvements.
The Thoracic Surgery cell is one of Australia’s
busiest centres for the treatment of lung cancer
and is considered the most advanced centre for
minimally invasive surgical techniques for a range
ofВ diseases of the chest. Lung cancer, thoracoscopic
surgery and reducing post-operative pain are our
primary areas of research. Our headline project is the
use of DNA and RNA from lung cancers that have
been removed to predict behaviour of non-small
cell lung cancer. It is the major partner, along with
researchers at the Max Planck Institute in Germany,
in the largest lung cancer DNA project in the world.
It is expected to exploit weaknesses found in lung
cancers that may lead to new drug treatments for
this aggressive disease.
Major projects
Cardiac projects
• STICHES – An NIH-sponsored worldwide
study extending follow up of surviving subjects
randomized in the STICH trial myocardial
revascularization hypothesis (Hypothesis 1) for
anВ additional 5 years to acquire critically important
longer-term (10-year average) information on
patients with HF and LVSD treated with optimal
MED with and without CABG
• Cox-Maze III three year follow-up:
The St Vincent’s experience
• Early clinical experience with surgical ventricular
restoration for dilated ischaemic cardiomyopathy
• Insulin resistance, Adipocyte Biology
andВ Cardiovascular Disease
• Investigation of Causes of Heart Failure Study
• ATACAS Trial: Aspirin and Tranexamic Acid
forВ Coronary Artery Surgery
• Investigations into a TNF inhibitor to limit
complications following complex surgery
• Training status is not associated with an increased
risk of early or late mortality after isolated aortic
valve replacement surgery
• Adjunctive retrograde thoracic stent grafting
during repair of acute Debakey type 1 dissection
prevents development of thoracoabdominal
aorticВ aneurysms
• A mid-term follow-up of surgical ventricular
restoration of patients from the STICH era
• Association of pre-operative lipid levels on early
outcomes after CABG
• A four year retrospective nursing review comparing
emergency coronary artery bypass surgery
toВ elective coronary artery bypass surgery
• Endocarditis – a 10 year retrospective analysis
of outcomes at St Vincent’s Hospital
• Sternal wound infections: Microbiology
andВ diagnostic strategies
• Early experience of CoreValve implantation:
aВ pilotВ retrospective study
st vincent’s research report 2012
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Cardiothoracics
Thoracic projects
• Clinical Lung Cancer Genome Project –
anВ exploratory epidemiological genetics
studyВ inВ lung cancer
• Victorian Lung Cancer Initiative – A Victorian Cancer
Agency funded program bringing together experts
in cancer research to address four key projects:
The Victorian Lung Cancer Registry, The Victorian
Lung Cancer Bio-resource Network, The VCA Lung
Cancer Molecular Pathology Platform and The Lung
Cancer Chemoresistance Project
• The use of molecular profiling in early non-small cell
lung cancer to predict clinical course and identify
pathologically important genes
• Victorian Thoracic Malignancies Cohort Study
– a prospective collection of clinical data and
consent to access archived tissue from patients
with thoracic malignancies to assist with
identification of new targeted cancer therapies
• FGFR1 project – development of clinical trials
toВ investigate the effectiveness of FGFR1 inhibitors
in the treatment of squamous cell lung cancers
• WORLD Study: A phase III randomized trial
ofВ lobectomy vs sublobar resection for small
(≤2cm) peripheral non-small cell lung cancer
• PACT: Patient perceptions of adjuvant
chemotherapy (ACT) for early NSCLC:
WhatВ makes it worthwhile?
• ASSGO6PM: A prospective longitudinal cohort
studyВ describing quality of life in patients
undergoing pulmonary metastasectomy
forВ metastatic sarcoma
• INSTEP trial: Influence of NSAIDs on Short
Term Efficacy of Pleurodesis: A double-blind
randomized placebo-controlled trial
• PAINT study: Postoperative assessment
ofВ intercostal neuralgia after thoracotomy
and VATS – a prospective observational study
Our breakthrough finding in thoracics was
theВ discovery of excess copies of a gene called
FGFR1 in about a quarter of squamous cell lung
cancers. This has opened the way for clinical
trialsВ ofВ inhibitors of this gene. In collaboration
with the Anatomical Pathology department,
weВ have validated a test which is highly accurate
atВ detectingВ this gene abnormality.
Staff
Andrew Newcomb, Acting Director Cardiothoracic
Surgery 1.0EFT
Gavin Wright, Deputy Director Cardiothoracic
Surgery, Director of Surgical Oncology VMO 3
sessions
Philip Davis, Supervisor of Training Cardiothoracic
Surgery 1.0EFT
Michael Yii, Cardiac Surgeon VMO 3 sessions
Ian Nixon, Cardiac Surgeon VMO 1 session
Alexander Rosalion, Cardiac Surgeon
VMOВ 1В session
Naveed Alam, Thoracic Surgeon VMO 3 sessions
Jim Dimitriou, Cardiac Registrar 1.0EFT
Indra Noordstrand, Cardiac Registrar 1.0EFT
Jay Bahaskar, Thoracic Registrar
(February–July 2012) 1.0EFT
Marosh Vrtik, Thoracic Registrar
(August–December 2012) 1.0EFT
Paul Conaglen, Research Fellow
Zoe Wainer, Thoracic Surgical Oncology Translational
Research Fellow (RACS Research Fellowship)
Jane Mack, Research Coordinator 0.8EFT
Sue Callaghan, Research Assistant, 0.5EFT
Karen DuvГ©, Data Manager 0.6EFT
Students
Quality
Andrew Newcomb, Masters of Surgery
Our Cardiothoracic Surgery team performed the first
surgery in Australia of a ground-breaking sutureless
aortic valve replacement. The elimination of the need
for sutures decreases the impact of the surgery on
the patients and reduces the risk of complications.
The intent in the future is to perform the replacement
operation via a thoracotomy rather than sternotomy
significantly shortening the length of the procedure
and their subsequent recovery.
Gavin Wright, PhD student
Zoe Wainer, PhD student
st vincent’s research report 2012
40
Cardiothoracics
Theses passed in 2012
Jim Dimitriou – FRACS (Cardiothoracic Surgery),
Royal Australasian College of Surgeons
Indra Noordstrand – FRACS (Cardiothoracic
Surgery), Royal Australasian College of Surgeons
Service to the wider community
A Newcomb
• Royal Australasian College of Surgeons:
–– Professional Development and Standards
Board. ASCTS representative
–– Cardiothoracic Board of Studies
• University of Melbourne:
–– Honorary Senior Lecturer,
DepartmentВ ofВ Surgery
• Western and Central Metropolitan Integrated
Cancer Service:
–– Management Advisory Committee
• The Cancer Council, Victoria:
–– Victorian Cooperative Oncology Group (VCOG)
–– Medical Research Advisory Committee
• Journal Review:
–– Cancer
–– Australian and New Zealand Journal of Surgery
–– Heart, Lung & Circulation
–– Respirology
–– Journal of Thoracic Surgery
–– Innovations
–– Annals of Surgery
–– St Vincent’s Cluster Executive
• St Vincent’s Melbourne:
–– Division of Surgery Executive
–– Blood Transfusion Committee
–– Chairman of Patient Identification and Procedure
Matching Working Group
• St Vincent’s and Mercy Private Hospital:
–– Medical Advisory Committee
• ASCTS:
–– ASCTS Database Steering Committee member
• Journal Review:
–– Annals of Thoracic Surgery
–– European Journal of Cardiothoracic Surgery
–– Heart Lung and Circulation
–– Circulation: Arrhythmia and Electrophysiology
G Wright
• Royal Australasian College of Surgeons:
–– RACS Endoscopic Working Party, Victorian
State Committee
• Australian Lung Cancer Trials Group:
–– Scientific Advisory Committee
• St Vincent’s Melbourne:
–– Laser Safety Committee Member
Grants
Newcomb A
Assessment of Dysglycaemia in Cardiac Surgery,
St Vincent’s Hospital
$15,000 for 1 year ($15,000 in 2012)
Wright G
Gene Expression Profiling of Morphologic Subtypes
of Lung Adenocarcinoma: A new Taxonomy linking
Tumour Cell Behaviour to Histological Phenotype,
St Vincent’s Hospital
$15,000 for 1 year ($15,000 in 2012)
Wright G
ALTG 04/009 – PACT: Patients’ perceptions of
adjuvant chemotherapy (ACT) for early NSCLC:
What makes it worthwhile?, Cancer Australia
$287,425 for 2009–2012 ($95,800 in 2012)
Wright G
Victorian Lung Cancer Initiative, Monash University
$272,082 for 2011–2014 ($90,694 in 2012)
Wright G
CTMS (Cancer Trials Management Scheme)/VCTL
(Victorian Cancer Trials Link), Cancer Council Victoria
$8,580 for 2012–2013 ($4,290 in 2012)
Wright G
Clinical Lung Cancer Genome Project,
CollingwoodВ Rotary Club
$12,000 for 2012–2013 ($12,000 in 2012)
st vincent’s research report 2012
41
Cardiothoracics
Collaborations in research
• The Max Planck Institute, Cologne, Germany
(Clinical Lung Cancer Genome Project)
• Molecular Pathology Research Laboratory,
PeterВ MacCallum Cancer Centre
• Bernard O’Brien Institute
• Australian Catholic University,
CardiovascularВ Research Centre
Publications
Journal articles
A Newcomb
Saxena A, Dinh DT, Smith JA, Shardey GC,
Reid CM, Newcomb AE. (2012). Usefulness
ofВ postoperative atrial fibrillation as an independent
predictor for worse early and late outcomes after
isolated coronary artery bypass grafting (multicenter
Australian study of 19,497 patients). Am J Cardiol:
Jan 15; 109(2): 219–25.
Saxena A, Dinh DT, Yap CH, Reid CM, Billah B,
Smith JA, Shardey GC, Newcomb AE. (2012).
Critical analysis of early and late outcomes after
isolated coronary artery bypass surgery in elderly
patients. Ann Thorac Surg: Nov; 92(5): 1703–11.
Hofferberth SC, Foley PT, Newcomb AE, Yap KK,
Yii MY, Nixon IK, Wilson AM, Mossop PJ. (2012).
Combined proximal endografting with distal baremetal stenting for management of aortic dissection.
Ann Thorac Surg. Jan;93(1):95–102.
Saxena A, Dinh DT, Reid CM, Smith JA,
ShardeyВ GC, Newcomb AE.(2012). Sex differences
inВ outcomes following isolated coronary artery
bypass graft surgery in Australian patients:
analysisВ of the Australasian Society of Cardiac
andВ Thoracic Surgeons Cardiac Surgery database.
Eur J Cardiothorac Surg. Apr;41(4):755–62.
Campbell DJ, Somaratne JB, Jenkins AJ, Prior
DL, Yii M, Kenny JF, Newcomb AE, Kelly DJ,
BlackВ MJ. (2012). Reduced microvascular density
in non-ischemic myocardium of patients with recent
non-ST-segment-elevation myocardial infarction.
IntВ JВ Cardiol. Mar 27.
Hofferberth SC, Newcomb AE, Ryan MC, Yii MY,
Nixon IK, Rosalion A, Boston RC, Ward GM, Wilson
AM. (2012). High incidence of insulin resistance and
dysglycemia amongst nondiabetic cardiac surgical
patients. Ann Thorac Surg. Jul;94(1):117–22.
Palmer S, Mariani JA, Newcomb A, Stokes MB,
Burns AT. (2012). Successful application of a
PressureWire retrogradely across an ATS prosthetic
aortic valve to diagnose constrictive pericarditis.
Cardiovasc Revasc Med. Sep-Oct;13(5):289–91.
Hofferberth SC, Newcomb AE, Yii MY, Yap KK,
Boston RC, Nixon IK, Mossop PJ. (2012). Combined
proximal stent grafting plus distal bare metal stenting
for management of aortic dissection: Superior to
standard endovascular repair? J Thorac Cardiovasc
Surg. Oct;144(4):956–62.
Saxena A, Dinh DT, Reid CM, Smith JA, Shardey
GC, Newcomb AE. (2012). Does Preoperative Atrial
Fibrillation Portend a Poorer Prognosis in Patients
Undergoing Isolated Aortic Valve Replacement?
AВ Multicentre Australian Study. Can J Cardiol. Nov 8.
Campbell DJ, Somaratne JB, Jenkins AJ, Prior DL,
YiiВ M, Kenny JF, Newcomb AE, Schalkwijk CG,
Black MJ, Kelly DJ. (2012). Diastolic dysfunction
ofВ aging is independent of myocardial structure
butВ associated with plasma advanced glycation
end-product levels. PLoS One. 7(11):e49813.
G Wright
Steinfort DP, Russell PA, Tsui A, White G, Wright G,
Irving LB. Interobserver agreement in determining
non-small cell lung cancer subtype in specimens
acquired by EBUS-TBNA. (2012). Eur Respir J.
Sep;40(3): 699–705.
Paramanathan A, Wright G. Pulmonary
metastasectomy for sarcoma of gynaecologic
origin. (2012). Heart Lung Circ. Dec 20. pii: S1443–
9506(12)01369–8.
Wainer Z, Daniels MG, Callahan J, Binns D,
HicksВ RJ, Antippa P, Russell PA, Alam NZ,
ConronВ M, Solomon B, Wright GM. Sex and
SUVmax: Sex-Dependent Prognostication in Early
Non-Small Cell Lung Cancer. (2012). J. Nucl. Med.
Nov;53(11):1676–85.
st vincent’s research report 2012
42
Cardiothoracics
Peifer M, Fernandez-Cuesta LFA, Sos ML, …
Wright GM, …Thomas RK. (2012). Integrative
genome analyses identify key somatic driver
mutations of small-cell lung cancer. Nature Genetics.
2012 Oct;44(10):1104–10.
Wright GM. VATS lobectomy lymph node
management. (2012). Ann Cardiothorac Surg.
1(1): 51–55.
Wright GM. Video-assisted thoracoscopic
pulmonary resections – The Melbourne experience.
(2012). Ann Cardiothorac Surg. 1(1): 11–15.
Dear RF, Kelly PJ, Wright GM, Stalley P,
McCaughan BC, Tattersall MHN. (2012). Pulmonary
metastasectomy for bone and soft tissue sarcoma
inВ Australia: 114 patients from 1978 to 2008. Asia
Pac J Clin Oncol.. Sep;8(3):292–302.
Speaking engagements
A Newcomb
Minimally Invasive Conduit Harvest. Invited Lecture.
ANZSCTS ASM Hobart 2012
Minimally Invasive Valve Surgery. St Vincent’s
Hospital Inaugural Surgical Forum, November 2012
st vincent’s research report 2012
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Cardiovascular
ResearchВ Centre
The Cardiovascular Research Centre (CvRC)
conducts interdisciplinary cardiovascular
research, focusing on basic, clinical research
andВ improvement of health outcomes. The
Centre is collaboration among the School
ofВ Nursing, Midwifery and Paramedicine at
theВ Australian Catholic University, the School
of Medicine at the University of Melbourne
and St Vincent’s Hospital Melbourne.
Major projects
About us
• Refractory Hypertension: Renal Sympathetics
Radiofrequency Ablation
The objectives of CvRC are to conduct both basic
and clinical outcomes-focused research; to provide
research training and higher education career
pathways for health professionals; and to educate
the public and develop better health care initiatives
for prevention and treatment of CVD. CvRC hasВ nine
programs of research; each program is focused
onВ different aspects of CVD.
Interventional Cardiology investigates early and
effective CVD intervention through clinical trials.
Health Outcomes Research concentrates on
implementing research into clinical practice, with
anВ emphasis on the role of nurses. Prevention
of CVD addresses the established primary and
secondary risk factors which may lead to a
cardiac event. Psychosocial Research looks at the
psychosocial aspects of CVD, including behavioural
and lifestyle change, in order to reduce the risk and
burden of the disease. Cardiac Services studies the
pathophysiology of the pulmonary circulation and
interventional devices. Mental Health & Wellbeing
focuses on CVD-related depression in patients,
as well as its relation to other CVD risks such as
smoking and obesity. Heart Failure & Imaging looks
at the use of non-invasive cardiac imaging for early
detection of cardiac disease. Vascular & Cardiac
Surgery investigates new and innovative ways
toВ improve patient outcomes and develop efficient
procedures. Basic CVD Science aims toВ develop
new strategies and treatment approaches to
reduceВ the impact of chronic heart failure.
Within the nine programs of CvRC, the following
projects were underway in 2012:
Interventional Cardiology
• Percutaneous Aortic Valves (Corevalve study)
• BioAbsorbable Stents study
• BRANCH Bifurcation Stent study
• Platinum QCA & WH Sent study
• Coronary Sinus Contrast Scavenger: Osprey study
Health Outcomes Research
• Nurse-Led Risk Intervention Screening Clinic
(NL-RISC) – Completed
• Managing depression and anxiety risk in those
with cardiovascular disease: A nurse-led
intervention – Completed
• A secondary prevention patient centred model
for smoking cessation – Completed
• Strengthening Cardiac Care for Aboriginal and
Torres Strait Islander People with Acute Coronary
Syndrome – Completed
• Exploring Aboriginal patients’ experience
of acute cardiac care at St Vincent’s – Ongoing
• Cardiac Depression Scale (CDS) audit
– Implementing a depression pathway
forВ cardiacВ patients: An audit of its uptake
in the real-world – Completed
• Role of Dialysis – Nurse Practitioner Study
– Ongoing
Prevention of CVD
• Identification of a novel inflammatory biomarkers
• Plasma proteomics
• Inflammation and atherosclerosis
• Abnormalities in Nitric Oxide metabolism
role of DDAH/ADMA (Dimethylarginine
dimethylaminohydrolase/Asymmetric
dimethylarginine)
• Links between obesity, insulin resistance and CVD
• Prevention of Atherosclerosis
st vincent’s research report 2012
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Cardiovascular ResearchВ Centre
Psychosocial Research
• Cardiac structure and function in endurance athletes
• Psychosocial issues in cardiovascular
diseaseВ management
• Screening for cardiac abnormalities
inВ AustralianВ athletes
• Self-care and cognitive impairment
inВ chronicВ heartВ failure
• Effects of exercise training on cardiac structure
andВ function in indigenous footballers
• Neurocognitive aspects of depression and CVD
Cardiac Services
• Assessing early pulmonary hypertension
inВ scleroderma
• Echocardiographic assessment left ventricular
(LV)В function
• Echocardiographic assessment of cardiac
functionВ in athletes
Vascular and Cardiac Surgery
• Clinical and QoL follow-up of radial artery
harvestВ patients, comparing open and
endoscopicВ harvesting
• Functional assessment of endoscopically
harvested arteries compared to conventionally
harvested radial arteries
• Cost of health care delivery
• Coronary physiology and interventional devices
• Epidemiologically based outcomes research
intoВ high risk populations for cardiac surgery
Mental Health and Wellbeing
• Heart failure and left ventricular leads placed
atВ time of concomitant surgery
• An audit of current screening and referral
mechanisms towards the recognition
andВ treatment for depression in people
withВ cardiacВ disease
• Being �fat’ in today’s world: A socio-cultural
investigation of overweight and obesity
• An open trial of a (CBT)-based smoking cessation
intervention plus varenicline intervention in people
with a psychotic disorder
• Improving the lifestyles of people with
aВ psychoticВ illness
• An audit of metabolic monitoring in a mental
health service
• A longitudinal study of cardiac echocardiograms
inВ patients on clozapine
Heart Failure & Imaging
• An audit of cardiac echocardiograms in patients
on clozapine
• Surgical Treatment for Ischemic Heart Failure
Extension Study (STICHES) Trial
• Effect of diabetes on the heart
• Echocardiographic assessment of cardiac fibrosis
• Outcomes of aortic dissection using
aВ hybridВ approach
• Investigation of cardiotomy filtrate components
• Impact of use of different wound dressings
onВ wound infection rates
• Impact of mini cardiopulmonary bypass circuit
onВ inflammation and clinical outcomes
• Echocardiography Guided Cardiac
Resynchronization Therapy Clinical
InvestigationВ (EchoCRT)
• Surgical Treatment for Ischemic Heart Failure
Extension Study (STICHES) Trial
Basic CVD Science
• Novel therapeutic strategies to reduce the burden
of chronic heart failure
• Development of new anti-fibrotic drugs
forВ prevention of diabetic nephropathy
• Prevention and treatment of chronic heart
andВ kidney disease via epidemiological,
pharmacological device and cell based
approaches
• Assessment of early pulmonary arterial
hypertension using dobutamine stress
echocardiograms in patients with scleroderma
• NT-proBNP and the identification and treatment
ofВ structural heart disease and heart failure
inВ high-risk individuals
st vincent’s research report 2012
45
Cardiovascular ResearchВ Centre
Research highlights
A/Prof Karen-leigh Edward
• In May, St Vincent’s hosted the successful
Prevention Week, an event featuring daily activities
designed to raise awareness of CVD prevention.
The event was organised by CvRC’s Prevention
Group, which is chaired by A/Prof Andrew Wilson
and was co-ordinated by Ms Rhonda Sanders.
A/Prof David Prior
• In August, CvRC researchers had over 10 posters
on display at St Vincent’s Research Week.
Research Fellows, Assistants & Associates:
• Prof Linda Worrall-Carter was awarded the
Cardiovascular Nursing Lecture at the Cardiac
Society of Australia and New Zealand’s 60th
Annual Scientific Meeting.
Dr Chris Judkins
• A/Prof Karen-leigh Edward was awarded the
Emerging Leader Award at the Catholic Health
Australia 2012 Awards.
Dr Jan Cameron
Quality
Ms Rhonda Sanders
A/Prof Wilson leads the Risk Consortium at
St Vincent’s, Prevention @ St Vincent’s that focuses
on the use of evidence-based practice to ensure
early identification and treatment of cardiovascular
risk factors for individuals who have had a primary
vascular event related to arthrosclerosis. It aims
toВ help individuals to develop strategies that will
helpВ them to live with these risk factors.
Dr Muhammad Aziz Rahman
In this context, several programs are jointly working
on improving the options of patient care. For example,
nurse-led clinics have been implemented into the
service structure to screen patients for risk factors
such as depression and smoking. These clinics
areВ improving patient care and increasing awareness
of disease as a preventive measure. Several other
clinics and measurements are being verified for
future implementation into the service structure
ofВ the hospital.
Students
Staff
The University of Melbourne
Heads of Programs:
Prof Robert Whitbourn, Director of CvRC
Prof Linda Worrall-Carter, Director of CvRC
A/Prof Andrew Wilson, Deputy Director of CvRC
Prof David Thompson
Prof David Castle
A/Prof Chantal Ski
A/Prof Andrew MacIsaac
A/Prof Darren Kelly
Dr Andrew Newcomb
Dr Peter Mossop
Dr Jithendra Somaratne
Dr Sonny Palmer
Dr Paul Williams
Dr Carolina Chavez
Ms Jane Reid
Ms Karen Daws
Ms Elizabeth Hristov
Ms Christine Wright
Ms Katherine McQualter
Ms Sally Kemp
Australian Catholic University (ACU)
Ms Elizabeth Scruth, PhD student
Ms Lisa Kuhn, PhD student
Mr Malcolm Elliott, PhD student
Swinburne University
Ms Sarah Brennan, PhD student
Mr Akshat Saxena, MBBS student
Ms Andrea Philipou, PhD student
Dr Carol Silberberg, DMedSci student
Mr Dharshan Palasubramnain,
AdvancedВ MedicalВ Science student
Dr James Le Bas, PhD student
Dr Jennifer Coller, PhD student
Dr Maria Brosnan, PhD student
Mr Mark Waddingham, PhD student
st vincent’s research report 2012
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Cardiovascular ResearchВ Centre
Dr Melissa Tang, PhD student
Dr Nicole Joshua, PhD student
Dr Paul Conaglen, Masters of Surgery student
Mr Paul-Jon Goh, Advanced Medical
ScienceВ student
Ms Sophie Hofferberth, BMedSci student
• Member, Australian College of Critical Care Nurses
(ACCCN)
• Member, Royal College of Nursing, Australia
(RCNA)
• Member, Australian Cardiovascular Health
andВ Rehabilitation Association (ACRA)
Dr Stuart Murch, DMedSci student
• Member, National Tertiary Education Industry
Union (NTEU)
Ms Sue Lauder, PhD student
• Research Ambassador, Heart Foundation
Mr Xianzhong Lau, PhD student
Ms Zuhaili Zahari, Advanced Medical
ScienceВ student
Victoria University
International Conference Chair:
• Member for the Heart Foundation
ScientificВ Program
Mr Frank Perri, PhD student
Grant Review
Theses passed in 2012
• Australian Research Council
(LinkageВ andВ Discovery projects)
Ms Christina Tan. PhD, University of Melbourne
Dr Michael Zhang. PhD, University of Melbourne
Ms Fay Khong. PhD, University of Melbourne
Ms Suree Lekawanvijit. PhD, Monash University
Service to the wider community
Prof Robert Whitbourn
• Fellow, The Royal Australasian College
ofВ Physicians (FRACP)
• Fellow, The Cardiac Society of Australia
andВ NewВ Zealand (FCSANZ)
• Member, Asia-Pacific Society
ofВ InterventionalВ Cardiology
• Member, Australian Medical Association
• Member, The Medical Defence Association
ofВ Victoria
• Executive Member, Australia & New Zealand
Endovascular Therapies Meeting, 2007,
2008,В 2011
Prof Linda Worrall-Carter
• ARC Social Sciences Collaboration
(LinkageВ International funding)
• NHMRC
• Heart Foundation of Australia
• Killam Research Fellowship
(CanadaВ CouncilВ forВ the Arts)
• Nurses Board of Victoria
Editorial Board Member:
• Nursing & Health Sciences
Manuscript Review:
• International Journal of Cardiology
• European Journal of Heart Failure
• Heart and Lung
• European Journal of Cardiovascular Nursing
• Journal of Cardiovascular Nursing
• Australian Critical Care
• Contemporary Nurse
• Nursing & Health Sciences
• Founding Member, Australasian Cardiovascular
Nurses College (ACNC)
• Founding Member, Cardiovascular Nurses Council
(CSANZ)
• Affiliate Member, Cardiac Society of Australia
andВ New Zealand (CSANZ)
st vincent’s research report 2012
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Cardiovascular ResearchВ Centre
A/Prof Andrew Wilson
A/Prof Chantal Ski
• Organising committee,
ClinicalВ ResearchВ Excellence
• Member, Australian Psychological Society (APS)
• Chair, Victorian Clinical Researcher Network
• Member, National Foundation for Australian
Women
• Chair, Expert Advisory Group, Accreditation,
RoyalВ Australasian College of Physicians
• Lead Fellow, Accreditation (Adult Medicine),
RoyalВ Australasian College of Physicians
• Chair, Accreditation Subcommittee,
(AdultВ Medicine), Royal Australasian
CollegeВ ofВ Physicians
• Member, Centre for Loss and Grief Education
• Member, Cardiac Society of Australia
andВ NewВ Zealand (CSANZ)
• Member, Mental Health Interuniversity
ResearchВ Group (MHIRG)
A/Prof Andrew MacIsaac
Prof David Thompson
• Fellow, Cardiac Society of Australia
andВ NewВ Zealand
• Member, Royal College of Nursing Research
Society
• Member, National Heart Foundation of Australia
• Member, British Psychological Society
• Member, British Cardiovascular Society
• Member, British Association for Cardiac
Rehabilitation
Editorial Posts:
• Editor, European Journal
ofВ CardiovascularВ Nursing
• Fellow, Society for Cardiovascular Angiography
&В Intervention (SCAI)
• Member, American Society of Echocardiography
(ASE)
Professional Activities:
• Federal Councillor and Member of the Continuing
Education and Recertification Committee,
CardiacВ Society of Australia and New Zealand
• Editorial Board Member, European Journal
ofВ Cardiovascular Prevention & Rehabilitation
• Member of National Examining Panel
andВ Overseas Trained Physicians (OTP)
Assessment Panel, The Royal Australasian
CollegeВ of Physicians
• Editorial Board Member,
Worldviews on Evidence-Based Nursing
• Member of the Cardiovascular Guidelines
WritingВ Group for Therapeutic Guidelines
• Editorial Board Member, BMC Nursing
Prof David Castle
• Editorial Board Member,
IntensiveВ &В CriticalВ CareВ Nursing
Professional Affiliations:
• Regional Editor, International Journal
ofВ NursingВ Practice
• Editorial Board Member, Heart
• Fellow, Royal College of Psychiatrists,
UnitedВ Kingdom
Committees:
• Fellow, Royal Australian and New Zealand College
of Psychiatrists
• European Society of Cardiology, Council
onВ Cardiovascular Nursing and Allied
ProfessionsВ Board
• European Society of Cardiology, Council
onВ Cardiovascular Nursing and Allied
ProfessionsВ Science Committee, Chair
• British Heart Foundation Overarching Nurses
andВ Allied Professions Committee
• Association of European Psychiatrists (AEP)
• International Society for Bipolar Disorders (ISBD)
• Schizophrenia International Research Society (SIRS)
• International Society for Affective Disorders (ISAD)
• Australian and New Zealand Association of
Psychiatry, Psychology and Law (ANZAPPL)
• British Association for Nursing in Cardiovascular
Care Council
st vincent’s research report 2012
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Cardiovascular ResearchВ Centre
• Australasian Society for Psychiatry Research
(ASPR)
• Anxiety Recovery Centre of Victoria (ArcVic)
• European College of Neuropsychopharmacology
(ECNP) (Corresponding member)
• Australian Association of Smoking Cessation
Professionals (Full Member)
A/Prof Karen-leigh Edward
Professional Memberships:
• Chair/Director of the ACU/SVPM Nursing
Research Unit, SVPM
• Chair and Founder, Mental Health Interuniversity
Research Group (MHIRG)
• Fellow, Australian College of Mental Health Nurses
• Credentialed MHN, Australian College
ofВ MentalВ Health Nurses (ACMHN)
• Member, SVHM Research Week Planning
Committee, SVHM
• Member, University HREC,
AustralianВ CatholicВ University
• Member of the Research in Standing Committee,
Australian Catholic University
• Senior Research Associate,
BanyuleВ CommunityВ Health Centre
A/Prof David Prior
Professional Memberships:
• Chairman of Victorian division of Cardiac Society
of Australia & New Zealand
• Australasian Society for Ultrasound in Medicine
• American College of Cardiology
• American Society of Echocardiography
• Board member, Heart Foundation Victoria
Journal reviewer:
• International Journal of Sports Medicine
• Journal of the American College of Cardiology
• JACC Cardiovascular Imaging
• The American Journal of Cardiology
• Heart Lung and Circulation
• The Journal of Human Hypertension
Dr Andrew Newcomb
Committee Positions:
• RACS Cardiothoracic Board of Studies
• HREC-A Professional member, SVHM
• Clinical Policy Review Committee, SVHM
• Member, Integrated Risk Committee, SVPM
• Younger Surgeons’ Group Representative
onВ ASCTS Council
• Member, OHS Committee, SVPM
• ASCTS Database Steering Committee member
• Member, Research Committee, SVPM
• St Vincent’s Blood Transfusion Committee
• Member, Heads of Department, SVPM
• Division of Surgery Executive, St Vincent’s Hospital
• Member, Mercy Private NUM Group, SVPM
• University of Melbourne SVH Cluster executive
• Member, St Vincent’s Private NUM Group, SVPM
• Royal Australasian College of Surgeons
Professional Development and Standards Board.
ASCTS representative
• Member, MHN in Private Practice Group,
Australian College of Mental Health Nurses
• Member, Nurse-led Enquiry Group (Mental health)
Austin Health
• Member, Best Practice Group, (Acute care)
AustinВ Health
• Research Associate, NaCCOR/ACU
Professional Memberships:
• Fellow Royal, Australian College of Surgeons
• Full Member, Australasian Society
ofВ Cardiothoracic Surgeons
• Fellow, Cardiac Society of Australia
andВ NewВ Zealand
• International Member,
SocietyВ ofВ ThoracicВ Surgeons
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Cardiovascular ResearchВ Centre
• Senior Medical Staff Association,
St Vincent’s Hospital
• Journal Endocrinology
• Australian Medical Association
• Circulation and Laboratory Investigation
• Expert Opinions
• Medical Indemnity Protection Society
Journal Reviewer:
• Annals of Thoracic Surgery
• European Journal of Cardiothoracic Surgery
• Medical Science Monitor
• Anatolian Journal of Cardiology
• Heart Lung and Circulation
A/Prof Darren Kelly
Professional Memberships:
• Member and Fellow, American Society
ofВ Nephrology (FASN)
• Member, American Diabetes Association
• Member, Australian and New Zealand Society
ofВ Nephrology
• Member, European Association for the Study
ofВ Diabetes.
• Member, European Diabetic Nephropathy
StudyВ Group
• Member, Australian Diabetes Society
• Subject Editor (Integrative Biology), Nephrology
• Member of the Australian Institute of Company
Directors (MAICD)
• Member of the RMIT Pharmaceutical Sciences
Program Advisory Committee
• Member of the Faculty of the Australasian
ReninВ Academy
Journal reviewer:
• Diabetologia
• Kidney International
• Journal of Diabetic Complications
• Diabetes Research and Clinical Practice
• American Journal of Pathology
• American Journal of Physiology
• Nephrology and also subject editor
ofВ integrativeВ biology
• Dialysis and Transplantation
Grants
Krum, H., Kelly, D.J., Reid, C.
Prevention and treatment of chronic heart and
kidney disease via epidemiological, pharmacological
device and cell-based approaches, NHMRC
$5,400,000 for 2010–2014
Stewart, S., Thompson, D.R., Abhayaratna, W.,
Marwick, T., Carrington, M., Gould, P., Kostner,
K., Inglis, S., Schuffham, P., Haluska, B & Ski C.F.
Integration of risk evaluation in cardiovascular
disease management programs, NHMRC
$3,200,000 for 2011–2015
Stewart, S., Brown, A., Thompson, D., Stocks, N.,
Scuffham, P., Eades, S., Carrington, M., Sliwa, K.
& Maguire, G.
Centre of Research Excellence to Reduce Inequality
in Heart Disease, NHMRC, Centres of Research
Excellence Health Services funding
$2,493,649 for 2012–2017
Brown, A., Carrington, M., Eades, S.,
Thompson,В D.R. & Zeitz, C.
The central Australian heart protection study:
A randomised trial of nurse-led, family based
secondary prevention of acute coronary syndromes,
NHMRC
2011–2015 ($1,830,401 in 2012)
Campbell, D., Prior, D., Liew, D., Wolffe, R.
NT-proBNP and the identification and treatment
ofВ structural heart disease and heart failure in
high-risk individuals, NHMRC
$1,490,773 for 2009–2013
Kelly, D.J.
Pre-clinical development of a novel compound
toВ treat diabetic heart disease, NHMRC
$471,706 for 2011–2013
Worrall-Carter, L., Page, K., Rolley, J., Thompson,
S., Daws, K., Leishman, M., McCarthy, S.,
Whitbourn, R., & MacIsaac, A.
Delivering best practice and education for
the contemporary cardiac catheter laboratory
environment, Medtronic
$160,000 for 2010–2012
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Cardiovascular ResearchВ Centre
Worrall-Carter, L., Page, K., Thompson, D.,
Ski,В C., Castle, D., Whitbourn, R., Salzberg, M.
&В Wilson, A.
Managing depression and anxiety risk in those with
cardiovascular disease: A nurse-led intervention,
beyondblue: the national depression initiative
$120,760 for 2011–2012
Cameron, J., Thompson, D.R. & Ski, C.F.
Evaluating an assessment tool to guide heart
failure self-care education, Nurse’s Board of Victoria,
Mona Menzies Postdoctoral Research Grant
$49,105 for 2012
Conaglen, P., Wilson, A.M. & Newcomb, A.E.
Insulin resistance and nitric oxide metabolism in
non-diabetic patients undergoing cardiac surgery,
St Vincent’s Hospital Melbourne
$19,964 for 2012
Chavez, C., Ski, C.F., Jelinek, M.
&В Thompson,В D.R.
Effectiveness of psychosocial interventions on comorbid depression and coronary heart disease/A
systematic review & meta-analysis., ACU
$13,200 for 2012
Stanley, M., Langham, R., Rahman, M.A.,
Worrall-Carter, L.
Dialysis Nurse Practitioner Model of Care
at St. Vincent’s Hospital, Melbourne: 10 Years
ofВ activity, Australian and New Zealand Society
ofВ Nephrology
$10,000 for 2012
Collaborations in research
National
• Austin Health
Worrall-Carter, L., Tramm, R., Daws, K.,
Schadewaldt, V. & Prasad, M.
Implementing a depression pathway for cardiac
patients: An audit of its uptake in the real-world,
St Vincent’s Hospital Melbourne
$15,159 for 2012
• Baker IDI Heart & Diabetes Institute
Cameron, J., Ski, C.F., New, G. & Thompson, D.R.
Evaluation of a heart failure patient self-care ability
screening tool: applying a sliding scale of nursing
intervention, ACU
$15,091 for 2012
• Royal Prince Alfred Hospital
Castle, D., Lautenschlager, N., Thompson, D.R.,
Ski, C.F., Rolley, J., Hsueh, A. & Moore, G.
Improving the mental health of carers of
stroke patients: A pilot study of Australian
Care Coordination (ACCORD) program,
St Vincent’s Hospital Melbourne
$15,000 for 2012
• Stanford University Medical Center, USA
Newcomb, A.
Assessment of dysglycemia in cardiac surgery,
St Vincent’s Hospital Melbourne
$15,000 for 2012
Publications
Wilson, A.
Abnormalities in the enzyme DDAH: A novel link
between diabetes and cardiovascular disease,
St Vincent’s Hospital Melbourne
$15,000 for 2012
• Curtin University
• Deakin University
• Monash University
• Pacific Clinical Research Group
• St Vincent’s Centre for Nursing Research (SVCNR)
• The Heart Foundation
International
• University of Alberta, Canada
• University of California, USA
• University of Kentucky, USA
• University of Pennsylvania, USA
Books
Castle, D.J., Hood, S., Starcevic, V. (eds.)
Anxiety Disorders: Current Understandings,
NovelВ Treatments. Australian Postgraduate Medicine,
Melbourne, 2012; ISBN 978–0–646–58113–2.
Book chapters
Castle, D.J., Olver, J. & Crino, R. (2012). Treatment
advances in OCD. In: Castle DJ, Hood S, Starcevic
V (eds.), Anxiety Disorders: Current Understandings,
Novel Treatments. Australian Postgraduate Medicine,
Melbourne. 137–152.
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Castle, D.J., Tran, N., Bosanac, P. & Alderton,
D. (2012). Management of acute behavioural
disturbance in psychosis. In: Castle, D.J., Copolov,
D.L., Wykes, T., Mueser, K. (eds.) Pharmacological
and Psychosocial Treatments in Schizophrenia,
3rdВ Ed, Informa Healthcare, London.
Silberberg, C., Castle, D.J., Koethe, D. (2012).
Cannabis, cannabinoids and bipolar disorder. In:
Castle DJ, Murray RM, D’Souza DC (eds.) Marijuana
and Madness 2nd Edition, Cambridge University
Press 2012; 129–136.
Castle, D.J., Tran. N., & Alderton, D. (2012).
Psychopharmacological management of
schizophrenia and related disorders. In:
CastleВ DJ, Copolov DL, Wykes T, Mueser
K (eds.)В Pharmacological and Psychosocial
TreatmentsВ in Schizophrenia, 3rd Ed, Informa
Healthcare, London.
Addis, S., Sherwood, D., Mace, W., Mancuso, S.G.,
Koloth, R. & Castle, D.J. (2012). A naturalistic study
of pharmacological management of behavioural
disturbance in psychosis. Journal of Psychiatric
Intensive Care, 8(2):120–125.
Castle, D.J., Wykes, T., Bosanac, P. & Knoesen, N.
(2012). Depression and anxiety in schizophrenia. In:
Castle DJ, Copolov DL, Wykes T, Mueser K (eds.)
Pharmacological and Psychosocial Treatments in
Schizophrenia, 3rd Ed, Informa Healthcare, London.
Clark, A.M., Ski, C. & Thompson, D.R. (2012).
Heart failure disease management: An update.
In: Best Practices in the Behavioral Management
of Chronic Disease. Volume 2: Other Medical
Disorders. (Eds: Trafton, J.A. & Gordon, W.)
SanВ Francisco, CA: Institute for Brain Potential,
S8–1 – S8–4.
Copolov, D. & Castle, D.J. (2012). The management
of negative symptoms. In: Castle DJ, Copolov DL,
Wykes T, Mueser K (eds.) Pharmacological and
Psychosocial Treatments in Schizophrenia, 3rd Ed,
Informa Healthcare, London.
James, W. & Castle, D.J. (2012). Addressing
cannabis use in people with psychosis. In: Castle
DJ, Murray RM, D’Souza DC (eds.) Marijuana and
Madness 2nd Edition,Cambridge University Press
2012; 225–233.
James, W., Mueser, K. & Castle, D.J. (2012).
Substance abuse comorbidity in schizophrenia. In:
Castle DJ, Copolov DL, Wykes T, Mueser K (eds.)
Pharmacological and Psychosocial Treatments in
Schizophrenia, 3rd Ed, Informa Healthcare, London.
Lautenschlager, N., Rabins, P.V. & Castle, D.J.
(2012). Schizophrenia in late life. In: Castle
DJ, Copolov DL, Wykes T, Mueser K (eds.)
Pharmacological and Psychosocial Treatments in
Schizophrenia, 3rd Ed, Informa Healthcare, London.
Journal articles
Bosanac, P. & Castle, D. (2012). Schizophrenia
andВ depression. Medical Journal of Australia,
1 (4): 36–39.
Brazionis, L., Ting, E., Itsiopoulos, C., Wilson, A.,
Hodge, A. (2012). The effects of fish or fish oil on the
omega-3 index. Nutrition and Dietetics, 69(1):5–12.
Brugaletta, S., Gomez-Lara, J., Garcia-Garcia, H.M.,
Heo, J.H., Farooq, V., Van Geuns, R.J., Chevalier,
B., Windecke,r S., McClean, D., Thuesen, L.,
Whitbourn, R., Meredith, I., Dorange, C.,Veldhof,
S., Rapoza, R., Ormiston, J.A., Serruys, P.W.
(2012). Analysis of 1В year virtual histology changes
in coronary plaque located behind the struts of the
everolimus eluting bioresorbable vascular scaffold.
International Journal of Cardiovascular Imaging,
28(6):1307–1314.
Buck, H. G., Lee, C. S., Moser, D. K., Albert,В N.В M.,
Lennie, T., Bentley, B., Worrall-Carter, L., &
Riegel, B. (2012). Relationship between self-care
and health-related quality of life in older adults
with moderate to advanced heart failure. Journal
of Cardiovascular Nursing, 27(1):8–15..
Campbell, D.J., Somaratne, J.B., Jenkins, A.J.,
Prior, D.L., Yii, M., Kenny, J.F., Newcomb, A.E.,
Schalkwijk, C.G., Black, M.J. & Kelly, D.J. (2012).
Diastolic dysfunction of aging is independent of
myocardial structure but associated with plasma
advanced glycation end-product levels. PLoS One.
7(11):e49813.
Castle D. (2012). Is it appropriate to treat people
at high risk before the onset of psychosis?
MedicalВ Journal of Australia, 196(9):557.
Castle, D. & Bosanac, P. (2012). Depression and
schizophrenia. Advances in Psychiatric Treatment,
18:280–288.
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Castle, D. (2012). The truth and nothing but
the truth, about early intervention in psychosis.
Australian and New Zealand Journal of Psychiatry,
46(1):10–13.
Edward, K., & Robins, A. (2012). Dual diagnosis
asВ described by those who experience the disorder
– Using the internet as a source of data, International
Journal of Mental Health Nursing, 21(6), 550–559.
Castle, D., Baker, A.L., Richmond, R., Filia, S.,
Harris, D. & Pirola-Merlo, A.J. (2012). Varenicline plus
healthy lifestyles in people with a psychotic disorder.
Annals of Clinical Psychiatry, 24:2–8.
Edward, K., Felstead, B., & Mahoney, A-M. (2012).
Hospitalised Mental Health Patients and Oral Health,
Journal of Psychiatric and Mental Health Nursing,
19(5), 419–425.
Castle, D., Piterman, L. & Berk, M. (2012). Difficultto-treat depression. Medical Journal of Australia,
1(4):4–5.
Edward, K., Nelson-Hearity, R., & Felstead, B.
(2012). Service integration for the dually diagnosed.
Australian Journal of Primary Care.18(1):17–22.
Castle, D.J. (2012). Schizoaffective disorder.
Advances in Psychiatric Treatment, 18(1):32–33.
Elliott, M., Page, K. & Worrall-Carter, L. (2012).
Reason’s accident causation model: Application to
adverse events in acute care. Contemporary Nurse,
43(1):14–20.
Chan, E.W., Kong, D.C.M., Knott, J.C. & Castle,
D.J. (2012). Ethical issues regarding interventions
forВ behavioural disturbance in psychotic disorders.
Asia Pacific Psychiatry, 4:140–143.
Chavez, C.A., Ski, C.F., Thompson, D.R.
(2012). Depression and coronary heart disease:
Apprehending the elusive black dog. International
Journal of Cardiology, 158(3):335–336.
Clark, A.M., Redfern, J., Thompson, D.R., Briffa, T.
(2012). More data, better data or improved evidence
translation: What will improve cardiovascular
outcomes? International Journal of Cardiology,
155(3):347–349.
Clark, A.M., Thompson, D.R. (2012). Medicare
Health Support Pilot Program. New England
Journal of Medicine, 366(7):666–668.
Cooper, J., Mancuso, S., Borland, R., Slade, T.,
Galletly, C. & Castle, D. (2012). Tobacco smoking
among people living with a psychotic illness:
TheВ second Australian survey of psychosis.
Australian and New Zealand Journal of Psychiatry,
46(9):851–863.
Dolan, M., Castle, D. & McGregor, K. (2012).
Criminally violent victimisation in schizophrenia
spectrum disorders: the relationship to symptoms
and substance abuse. BMC Public Health,
12(1):445.
Edgley, A.J., Krum, H. & Kelly, D.J. (2012).Targeting
fibrosis for the treatment of heart failure – a role
for transforming growth factor-ОІ. Cardiovascular
Therapeutics, 30(1):e30–e40.
Farooq, V., Gomez-Lara, J., Brugaletta, S.,
Gogas, B.D., Garcìa-Garcìa, H.M., Onuma, Y.,
Van Geuns, R.J., Bartorelli, A., Whitbourn, R.,
Abizaid, A., Serruys, P.W. (2012). Proximal and distal
maximal luminal diameters as a guide to appropriate
deployment of the ABSORB everolimus-eluting
bioresorbable vascular scaffold: A Sub-Study of
theВ ABSORB Cohort B and the On-Going ABSORB
EXTEND Single Arm Study. Catheterization and
Cardiovascular Interventions, 79(6):880–888.
Galletly, C., Foley, D., Waterreus, A., Watts, G.,
Castle, D., McGrath, J., Mackinnon, A. & Morgan,
V. (2012). Cardiometabolic risk factors in people
withВ psychosis: The second Australian national
survey of psychosis. Australian & New Zealand
Journal of Psychiatry, 46(8): 753–761.
Gilbert, M., Chamberlain, J.A., White, C.R., Mayers,
P.W., Pawsey, B., Liew, D., Musgrave, M., Crawford,
K., Castle, D.J. (2012). Controlled clinical trial of a
self-management program for people with a mental
illness in an Adult Mental Health Service: the Optimal
Health Program (OHP). Australian Health Review,
36(1):1–7.
Gilbert, R.E., Zhang, Y., Williams, S. J.,
Zammit,В S.В C., Stapleton, D. I., Cox, A. J.,
Krum,В H., Langham, R. G. & Kelly, D.J. (2012).
AВ purpose-synthesised anti-fibrotic agent attenuates
experimental kidney diseases in the rat. Plos One,
7(10):e47160.
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Gleeson, A., Castle, D. (2012). Attention deficit
hyperactivity disorder and bipolar disorder.
Advances in Psychiatric Treatment, 18:198–204.
Gogas, B.D., Serruys, P.W., Diletti, R., Farooq, V.,
Brugaletta, S., Radu, M.D., Heo, J.H., Onuma,
Y., Van Geuns, R.-J.M., Regar, E., De Bruyne,В B.,
Chevalier, B., Thuesen, L., Smits, P.C., Dudek,В D.,
Koolen, J., Windecker, S., Whitbourn, R., MiquelHebert, K., Dorange, C., Rapoza, R., Garcia-Garcia,
H.M., McClean, D. & Ormiston, J.A. (2012). Vascular
response of the segments adjacent toВ the proximal
and distal edges of the ABSORB everolimus-eluting
bioresorbable vascular scaffold: 6-Month and
1-year follow-up assessment – A virtual histology
intravascular ultrasound study from the first-in-man
ABSORB cohort B trial. JACC:В Cardiovascular
Interventions, 5(6):656–665.
Gomez-Lara, J., Diletti, R., Brugaletta, S., Onuma,В Y.,
Farooq, V., Thuesen, L., McClean, D., Koolen,В J.,
Ormiston, J.A., Windecker, S., Whitbourn, R.,
Dudek, D., Dorange, C., Veldhof, S., Rapoza,В R.,
Regar, E., Garcia-Garcia, H.M., Serruys, P.W.
(2012). Angiographic maximal luminal diameter
andВ appropriate deployment of the everolimuseluting bioresorbable vascular scaffold as assessed
by optical coherence tomography: an ABSORB
cohort B trial sub-study. EuroIntervention,
8(2):214–224.
Gray, W.A., Yeung, A.C., Cutlip, D.E., Popma,В J.J.,
Fitzgerald, P.J., Williams, D.O., Heuer, H.,
O’Shaughnessy, C.D., Overlie, P.A., Mann, J.T.,
Cannon, L.A., Hermiller, J.B., Henry, T.D.,
Whitbourn, R., Stuckey, T.D., Midei, M.G., Coe, J.,
Schwartz, L.B. (2012). A randomized, controlled,
multi-center trial comparing the safety and efficacy
ofВ zotarolimus-eluting and paclitaxel-eluting stents
in de novo lesions in coronary arteries: Final results
of the ZoMaxx II trial. International Journal of
Cardiology, 157(1):96–101.
GutiГ©rrez-Chico, J.L.,В Gijsen, F.,В Regar, E.,
Wentzel, J.,В De Bruyne, B.,В Thuesen, L.,
Ormiston,В J.,В McClean, D.R.,В Windecker,
S., Chevalier, B.,В Dudek, D.,В Whitbourn,
R.,В Brugaletta,В S., Onuma, Y. &В Serruys, P.W.
(2012).В Differences in neointimal thickness
between the adluminal and the abluminal sides
ofВ malapposed and side-branch struts in a
polylactide bioresorbable scaffold: Evidence
inВ vivoВ about the abluminal healing process.
JACC: Cardiovascular Interventions, 5(4):428–435.
Hofferberth, S.C., Foley, P.T., Newcomb,В A.E.,
Yap,В K.K., Yii, M.Y., Nixon, I.K., Wilson,В A.M.,
Mossop, P.J. (2012). Combined proximal
endografting with distal bare-metal stenting
forВ management of aortic dissection.
The Annals of Thoracic Surgery, 93(1):95–102.
Hofferberth, S.C., Newcomb, A.E., Ryan, M.C.,
Yii,В M.Y., Nixon, I.K., Rosalion, A., Boston,В R.C.,
Ward, G.M., Wilson, A.M. (2012). HighВ incidence
of insulin resistance and dysglycemia amongst
nondiabetic cardiac surgical patients.
Annals of Thoracic Surgery, 94(1):117–123.
Hofferberth, S.C., Newcomb, A.E., Yii, M.Y.,
Yap,В K.K., Boston, R.C., Nixon, I.K., Mossop, P.J.
(2012). Combined proximal stent grafting plus
distal bare metal stenting for management of aortic
dissection: Superior to standard endovascular
repair? Journal of Thoracic and Cardiovascular
Surgery, 144(4):956–962.
Jaarsma, T., Strömberg, A. & Thompson, D.R.
(2012). What’s going on at age 11: development
ofВ the European Journal of Cardiovascular Nursing.
European Journal of Cardiovascular Nursing,
11(1):7–8.
Jenkins, M.J., Edgley. A.J., Sonobe, T., Umetani,
K., Schwenke, D.O., Fujii, Y., Brown, R.D., Kelly,
D.J., Shirai, M. and Pearson, J.T. (2012). Dynamic
synchrotron imaging of diabetic rat coronary
microcirculation in vivo. Arteriosclerosis, Thrombosis,
and Vascular Biology, 32(2):370–377.
Jones, K., Castle, D., Curran, E. & Piterman, L.
(2012). Difficult-to-treat depression: What do general
practitioners think? Medical Journal of Australia,
1(4):6–8.
Klompstra, L.V., Jaarsma, T., Moons, P., NorekvГҐl,
T.M., Smith, K., Martensson, J., Thompson, D.R.,
De Geest, S., Lenzen, M. & Strömberg, A. (2012).
Anaemia and iron deficiency in cardiac patients:
what do nurses and allied professionals know?
European Journal of Cardiovascular Nursing,
11(Suppl 1):S90–5.
Knoesen, N.P., Mancuso, S.G., Thomas, S.,
Komesaroff, P., Lewis, S. & Castle, D.J. (2012),
Relationship between severity of obesity and mental
health: An Australian community survey. Asia-Pacific
Psychiatry, 4:67–75.
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Kume, T., Waseda, K., Koo, B.-K.,
Botelho,В R., Verheye, S., Whitbourn, R.,
Meredith, I., Worthley,В S., Hai, K.T., Yock,
P.G., AzevedoВ DeВ Oliveira, F.R., Abizaid, A.,
Fitzgerald,В P.J., Honda, Y. (2012). Intravascular
ultrasound comparison of small coronary lesions
between novel guidewire-based sirolimus-eluting
stents and conventional sirolimus-eluting stents.
Journal of Invasive Cardiology, 24(10):489–493.
La Gerche, A., Burns, A.T., D’Hooge, J.,
MacIsaac,В A.I., HeidbГјchel, H., Prior, D.L.
(2012). Exercise strain rate imaging demonstrates
normal right ventricular contractile reserve and
clarifies ambiguous resting measures in endurance
athletes. Journal of the American Society
of Echocardiography, 25(3):253–262.
La Gerche, A., Burns, A.T., Taylor, A.J.,
MacIsaac,В A.I., Heidbuchel, H. & Prior, D.L. (2012).
Maximal oxygen consumption is best predicted
by measures of cardiac size rather than function
in healthy adults. European Journal of Applied
Physiology, 112(6):2139–2147.
La Gerche, A., MacIsaac, A., Burns, A.T.,
Mooney,В D.J., Inder,W.J., Taylor, A.J., Bogaert,В J.,
Heidbuchel, H., & Prior, D.L. (2012). Exercise
induced right ventricular dysfunction and structural
remodelling in endurance athletes. European Heart
Journal, 33(8):998–1006.
Lauder, S., Chester, A., Castle, D., Dodd,S.,
Berk,В L., Klein, B., Austin, D., Gilbert, M.,
Chamberlain, J.A., Murray, G., White, C. & Berk, M.
(2012). The development of an online intervention
for bipolar disorder. Psychology, Health and
Medicine,1–11.
Layland, J., MacIsaac, A.I., Burns, A.T.,
Somaratne,В J.B., Leitl, G., Whitbourn, R.J.,
Wilson,В A.M. (2012) When collateral supply
isВ accounted for epicardial stenosis does not
increase microvascular resistance. Circulation:
Cardiovascular Interventions, 5(1):97–102.
Layland, J., Whitbourn, R., MacIsaac, A.,
Somaratne, J., Wilson, A. (2012). Takotsubo
cardiomyopathy: reversible elevation in
microcirculatory resistance. Cardiovascular
Revascularization Medicine, 13(1):66–68.
Layland, J.J., Whitbourn, R.J., Burns, A.T.,
Somaratne, J., Leitl, G., MacIsaac, A.I., Wilson,В A.
(2012). The index of microvascular resistance
identifies patients with periprocedural myocardial
infarction in elective percutaneous coronary
intervention. Heart, 98(20):1492–1497.
Lekawanvijit, S., Kompa, A.R., Manabe, M.,
Wang,В B.H., Langham, R.G., Nishijima, F., Kelly,В D.J.
& Krum, H. (2012). Chronic kidney disease-induced
cardiac fibrosis is ameliorated byВ reducing circulating
levels of non dialyzable uremic toxin, indoxyl sulfate.
Plos One, 7(7);e41281.
Lekawanvijit, S., Kompa, A.R., Zhang, Y.,
Wang,В B.H., Kelly, D.J. & Krum, H. (2012).
Myocardial infarction impairs renal function,
inducesВ renal interstitial fibrosis and increases
renalВ KIM-1 expression: implications for cardiorenal
syndrome. American Journal of Physiology – Heart
and Circulatory Physiology, 302(9):H1884–H1893.
McGregor, K., Castle, D., Dolan, M. (2012).
Schizophrenia spectrum disorders, substance
misuse, and the four-facet model of psychopathy:
the relationship to violence. Schizophrenia Research,
136(1–3):116–121.
McLellan, A. & Prior, D. (2012). Cardiac stress
testing: Stress electrocardiography and stress
echocardiography. Australian Family Physician,
41(3):119–122.
Monshat, K., Bosanac, P., Khorsen, G., Gaynor, N.,
Nittoli, D., Castle, D. (2012). Are psychiatric Crisis
and Assessment and Treatment Team clinicians
on the psychotherapy front line? Australasian
Psychiatry, 20(1):40–43.
Monshat, K., Castle, D.J. (2012).
Mindfulness training: An adjunctive role in
the medical management of chronic illness?
Medical Journal of Australia, 196(9):569–571.
Moore, E., Mancuso, S., Slade, T., Galletly, C.
& Castle, D. (2012). The impact of alcohol and
illicit drugs on people with psychosis: The second
Australian national survey of psychosis. Australian
& New Zealand Journal of Psychiatry, 46(9):864–878.
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Morgan, V., Waterreus, A., Jablensky, A., Mackinnon,
A., McGrath, J.J., Carr, V., Bush, R., Castle, D.,
et al. (2012). People living with psychotic illness
in 2010: The second Australian national survey
ofВ psychosis. Australian & New Zealand Journal
of Psychiatry, 46(8):735–752.
Palmer, S., Mariani, J.A., Newcomb, A., Stokes,
M.B. & Burns, A.T. (2012). Successful application
of a PressureWire retrogradely across an ATS
prosthetic aortic valve to diagnose constrictive
pericarditis. Cardiovascular Revascularization
Medicine. 13(5):289–291.
Petrakis, M., Penno, S., Oxley, J., Bloom, H.
&В Castle, D. (2012). Early psychosis treatment
inВ an integrated model within an adult mental health
service. European Psychiatry, 27(7):483–488.
Prior, D.L., La Gerche, A. (2012). The athlete’s heart.
Heart, 98(12):947–955.
Rolley, J.X. & Thompson, D.R. (2012).
Cardiovascular disease: Is it time to finally recognise
it as a complex, chronic life-span illness? European
Journal of Cardiovascular Nursing, 11(2):135–137.
Sankaranarayanan, A. & Castle, D. (2012).
Monitoring and managing metabolic syndrome
inВ persons with mental illness: the case for.
AP Journal of Psychological Medicine, 13:9–13.
Saxena, A., Dinh, D.T., Reid, C.M., Smith, J.A.,
Shardey, G.C. & Newcomb, A.E. (2012). Sex
differences in outcomes following isolated coronary
artery bypass graft surgery in Australian patients:
analysis of the Australasian Society of Cardiac
andВ Thoracic Surgeons Cardiac Surgery database.
European Journal of Cardio-Thoracic Surgery,
41(4):755–762.
Saxena, A., Dinh, D.T., Reid, C.M., Smith,В J.A.,
Shardey, G.C., Newcomb, A.E. (2012).
Usefulness of Post-Operative Atrial Fibrillation
asВ an Independent Predictor for Worse Early
andВ Late Outcomes after Isolated Coronary Artery
Bypass Grafting (Multicentre Australian Study of
19497 Patients). American Journal of Cardiology,
109(2):219–225.
Saxena, A., Poh, C.L., Dinh, D.T., Smith, J.A.,
Shardey, G.C., Newcomb, A.E. (2012). Early and
late outcomes after isolated aortic valve replacement
in octogenarians: an Australasian Society of Cardiac
and Thoracic Surgeons Cardiac Surgery Database
Study. European Journal of Cardiothorac Surgery,
41(1):63–68.
Scruth, E., Page, K., Cheng, E., Campbell, M., &
Worrall-Carter, L. (2012). Risk determination after
an Acute Myocardial Infarction: Review of clinical
risk prediction tools for the Clinical Nurse Specialist.
Clinical Nurse Specialist Journal, 26(1):35–41.
Scruth, E., Worrall-Carter, L., Cheng, E., Page,В K.
(2012). Profiles of primary cardiovascular risk
inВ STEMI: How do these differ between men
andВ women? Primary Care Cardiovascular Journal,
5(4):176–180
Scruth, E., Worrall-Carter, L., Cheng, E., Rolley, J.
& Page, K. (2012). Assessing risk post intervention
for an acute coronary syndrome: A review of the
risk assessment tools and their development.
Contemporary Nurse Journal, 43(1):2–13.
Shawyer, F., Farhall, J., Mackinnon, A., Sims,В E.,
Ratcliff, K., Thomas, N., Larner, C., Trauer,
T., Castle, D., Mullen, P., Copolov, D. (2012).
AВ randomised controlled trial of AcceptanceBased Cognitive Behaviour Therapy for command
hallucinations in psychotic disorders. Behaviour
Research and Therapy, 50(2):110–121.
Ski, C., Page, K., Thompson, D., Cummins, R.,
Salzberg, M., & Worrall-Carter, L. (2012). Clinical
outcomes associated with screening and referral
for depression in an acute cardiac ward. Journal
of Clinical Nursing, 21(15–16):2228–2234.
Tan, S.M., Zhang, Y., Wang, B., Tan, C.Y.,
Zammit,В S.C., Williams, S.J., Krum, H. & Kelly, D.J.
(2012). An orally active anti-fibrotic compound, FT23
attenuates structural and functional abnormalities in
an experiemental model of diabetic cardiomyopathy.
Clinical and Experimental Pharmacology and
Physiology, 39(8):650–656.
Tang, M.L., Pan, D.J.W., Castle, D. & Choong, P.
(2012). A systematic review of the recent quality
of life studies in adult extremity sarcoma survivors.
Sarcoma, Article ID 171342.
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Taylor, R.S. on behalf of the 2011 Cochrance
reviewВ authors. (2012). The RAMIT trial: its results
in the context of 2012 Cochrane Review. Heart,
98(8):672–673.
Thompson, D.R. & Clark, A.M. (2012). Addressing
the complexity conundrum in nursing. International
Journal of Nursing Studies, 49(3):247–248.
Thompson, D.R. & Clark, A.M. (2012). The
complexity conundrum: Nursing interventions for
complex health problems. Contemporary Nurse,
40(2):277–280.
Thompson, D.R. (2012). Motivational interviewing
improves patients’ mood and reduces mortality
12 months poststroke. Evidence-Based Nursing,
15(2):35.
Thompson, D.R., Clark, A.M. (2012). The five
top bad reasons why nurses don’t publish in
impactful journals. Journal of Advanced Nursing,
68(8):1675–1678.
Tran, N. & Castle, D. (2012). Outcomes from
aВ regular Medication Information Programme
forВ consumers with a mental illness.
Australasian Psychiatry, 20(2):143–147.
Waghorn, G., Saha, S., Harvey, C., Morgan, V.,
Waterreus, A., Bush, R., Castle, D., Galletly, C.,
Stain, H.J., Neil, A.L., McGorry, P. & McGrath,В J.J.
(2012). �Earning and learning’ in those with psychotic
disorders: The second Australian national survey
of psychosis. Australian & New Zealand Journal
of Psychiatry, 46(8):774–785.
Wang, W., Chair, S.Y., Thompson, D.R. & Twinn,
S.F. (2012). Effects of home-based rehabilitation
onВ health-related quality of lifeand psychological
status in Chinese patients recovering from acute
myocardial infarction. Heart & Lung: The Journal
of Acute and Critical Care, 41(1):15–25.
Waterreus, A., Morgan, V., Castle, D., Galletly,
C., Jablensky, A., Di Prinzio, P. & Shah, S. (2012).
Medication for psychosis: consumption and
consequences: The second Australian national
survey of psychosis. Australian & New Zealand
Journal of Psychiatry, 46(8): 762–773.
Watson, R. & Thompson, D.R. (2012). Response
toВ Sasso, L. (2011) Commentary on Thompson,
D.R. & Watson, R. (2010) Guest editorial: h-indexes
and the performance of professors of nursing in the
UK. Journal of Clinical Nursing, 21(7–8):1193–1194.
Watson, R., Wang, W., Hare, D.L., Ski, C.F. &
Thompson, D.R. (2012). The Chinese version
ofВ theВ Cardiac Depression Scale: Mokken scaling.
Health and Quality of Life Outcomes, 10(1):33.
Watson, R., Wang, W., Ski, C.F., Thompson D.R.
(2012). The Chinese version of the Myocardial
Infarction Dimensional Assessment Scale (MIDAS):
Mokken scaling. Health and Quality of Life Outcomes,
10(1):2–4.
Weerasundera, R. & Castle, D. (2012). Extendedrelease quetiapine fumarate in the treatment of
bipolar disorder. Neuropsychiatry, 2:5(453–459).
Wong, I.K.Y., Andriessen, A., Charles, H.E.,
Thompson, D., Lee, D.T.F., So, W.K.W. &
Abel, M. (2012). Randomized controlled trial
comparing treatment outcome of two compression
bandaging systems and standard care without
compression in patients with venous leg ulcers.
Journal ofВ the European Academy of Dermatology
and Venereology, 26(1):102–110.
Wong, I.K.Y., Andriessen, A., Lee, D.T.F.,
Thompson, D., Wong, L.Y., Chao, D.V.K.,
So,В W.K.W. & Abel, M. (2012). Randomized
controlled trial comparing treatment outcome
ofВ twoВ compression bandaging systems and
standard care without compression in patients
withВ venous leg ulcers. Journal of Vascular Surgery,
55(5):1376–1385.
Worrall-Carter, L., Edward, K. & Page, K. (2012).
Women and cardiovascular disease: At a social
disadvantage? Collegian, 19(1):33–37.
Worrall-Carter, L., Ski, C., Thompson, D.,
Davidson, P., Cameron, J., Castle, D., & Page,В K.
(2012). Recognition and referral of depression
inВ patients with heart disease. European Journal
of Cardiovascular Nursing, 11(2):231–238.
Xu, B. & Whitbourn, R. (2012). Novel Anticoagulants
for Non-valvular Atrial Fibrillation. Heart Lung and
Circulation, 21(8):464–467.
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Zhang, Y., Edgley, A.J., Cox, A.J., Powell, A.K.,
Wang, B., Kompa, A.R., Stapleton, D.I., Zammit,
S.C., Williams, S.J., Krum, H., Gilbert, R.E. &
Kelly, D.J. (2012). FT011, a new anti-fibrotic drug,
attenuates fibrosis and chronic heart failure in
experimental diabetic cardiomyopathy. European
Journal of Heart Failure, 14(5):549–562.
Speaking engagements
Cameron, J., Perona, M., Ski, C.F.,
Thompson,В D.R. (2012). Identifying heart failure
patients’ physical, cognitive and emotional
functioning: A self-care screening tool. Australian
Cardiovascular Health and Rehabilitation Association
(ACRA) Conference, Brisbane, Australia. 13–15 Aug
Cameron, J., Perona, M., Ski, C.F., Thompson,В D.R.
(2012). Identifying chronic heart failure patients’
physical, cognitive and emotional functioning:
AВ self-care screening tool. (Moderated Oral Poster
Presentation). St Vincent’s Research Week, St
Vincent’s Hospital Melbourne, Australia. 22 August
Cameron, J., Ski, C.F., Thompson, D.R. (2012).
Development of an assessment tool and scoring
matrix for heart failure self-care ability. Australasian
Cardiovascular Nursing College Conference, Sydney,
Australia. 23–24 February
Castle, D. (2012). BDD: a disorder in search of
aВ nosological home. Invited speaker at Australian
Psychiatrist Expert Group Conference, Werribee,
Victoria, Australia. 20–22 April
Castle, D. (2012). Bipolar mixed states. Invited
speaker at Victoria Clinic, Melbourne, Australia.
22В August
Castle, D. (2012). Body image and teen mental
health. Invited keynote speaker at Rotary Mental
Health Forum, Beaumaris, Melbourne. 21 March
Castle, D. (2012). Clinical Research at St Vincent’s:
Academic and Translational Updates in Mental
Health. (Symposium Chair). St Vincent’s Hospital
Melbourne, Australia. 27 September
Castle, D. (2012). Depression with anxiety, anxiety
and depression, anxious depression? A role
forВ agomelatine? Speaker at Royal ANZ College
ofВ Psychiatrists Annual Conference, Hobart,
Australia. 20–23 May
Castle, D. (2012). Detecting non-adherence and
shared decision-making: two steps towards longterm remission in schizophrenia. Invited speaker
tourВ at Singapore (including Institute of Mental
Health, Singapore General Hospital, National
University Hospital). 27–28 August
Castle, D. (2012). Early intervention in psychosis
is not justified. Invited debater at Royal Melbourne
Hospital Mental Health Forum, Melbourne, Australia.
20 February
Castle, D. (2012). Early intervention in psychosis:
not enough, not early enough. Invited speaker
at Clinical Controversies Annual Conference,
Melbourne, Australia. 29 July
Castle, D. (2012). Enhancing treatment outcomes
in schizophrenia; The role of case management
inВ relapse prevention. Invited speaker tour at
HongВ Hong and Macau (including Kwai Chung
Hospital, Princess Mary Hospital). 29–31 August
Castle, D. (2012). Improving outcomes in
schizophrenia. Invited speaker at Fremantle Hospital
Mental Health Forum, Fremantle, Western Australia.
22 June
Castle, D. (2012). Improving outcomes in
schizophrenia: learnings from Australia. Invited
speaker at Royal College of Psychiatrists (UK)
Annual Congress, Liverpool, UK. 12 July
Castle, D. (2012). Medical Morbidity in
Schizophrenia: Recognition & Management.
Grand Round, St Vincent’s Hospital, Melbourne,
Australia. 28 May
Castle, D. (2012). Optimising schizophrenia outcomes.
Invited speaker at Broadmeadows Mental Health
Service, Melbourne, Australia. 4 April
Castle, D. (2012). Promoting good outcomes
inВ schizophrenia. Invited speaker at Eastern Health
Mental Health Forum, Melbourne, Australia.
21В August
Castle, D. (2012). Psychiatric aspects of marijuana;
Optimising schizophrenia outcomes. Invited speaker
at Centre for Remote Health, Alice Springs, Australia.
26–27 March
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Castle, D. (2012). Recent evidence in the
understanding of schizophrenia trajectory and
implications for clinical practice. Invited speaker
at PsyAcademy Asia Faculty Meeting, Bangkok,
Thailand. 25–26 May
Castle, D. (2012). Smoking and other cardiovascular
disease risk behaviours among people with severe
mental disorders; IV droperidol or olanzapine
asВ adjuncts to midazolam for the acutely
agitated patient: a mulit-centre, randomised,
double-blind, placebo-controlled, clinical trial
(poster presentations). Delegate at Third Biennial
Schizophrenia Research Society Conference,
Florence, Italy. 14–18 April
Castle, D. (2012). Will there be less work for future
old age psychiatrists if early psychosis interventions
actually work? Invited speaker at AUPOA Annual
Symposium, Challenges in current thinking about
mental disorders in the elderly, Melbourne, Australia.
24 February
Conaglen, P., Davis, P., Tran, L., Reid, C. &
Newcomb, A. (2012). Risk-Prediction Scoring
inВ Endocarditis. Validation of Aus-SCORE and STSBased EndoSCORE in Australia. Poster Presentation
at ANZSCTS ASM, Hobart, Tasmania, Australia.
Daws, K., Punch, A., Willis, J., Winters, M.,
Posenelli, S., Belfrage, M., MacIsaac, A.,
McDonald, L. & Worrall-Carter, L. (2012).
It’s not rocket science – small changes that make
aВ really big difference to health outcomes for
Aboriginal patients. Victorian Aboriginal Health
Conference 2012, Melbourne, Australia. 24–25 May
Daws, K., Worrall-Carter, L., Hristov, E., Rahman,
M.A., Wilson, A. (2012). Adherence to secondary
prevention medication guidelines for cardiovascular
disease: Baseline data from a nurse-led risk
intervention screening clinic. Poster presented at
St Vincent’s Research Week, St Vincent’s Hospital
Melbourne, Australia. 20–22 August
Edward, K., & Mills, C. (2012). The use of research
outreach ward seminars to build research capacity
and culture: an evaluation of staff perceptions,
St Vincent’s Research Week. Melbourne, VIC,
20–22 August
Edward, K., & Welch, A. (2012). Extending
qualitative research methods for healthcare research.
2nd International Nursing Research Conference
Kuala Lumpur, Malaysia. 9–10 February
Conaglen, P., Davis, P., Tran, L., Reid, C.
&В Newcomb, A. (2012). Surgery for Infective
Endocarditis in Australia. Postop and Mid-Term
Outcomes from the ANZSCTS Database. ANZSCTS
ASM. Hobart, Tasmania, Australia
Edward, K., Warelow, P., Hercelinskyj, G., Welch,
A., Hemingway, S., McAndrew, S., & Stephenson,
J. (2012). The Fabric of a Career in Mental Health
Nursing from an Australian and UK perspective,
ACMHN 38th International Mental Health Nursing
Conference “Fabric of life” Darwin, Australia,
4–7 October
Conaglen, P., Shan, L., Webb, D., Buratto,
E., Davis,В P., Yii, M, Nixon, I., Rosalion, A.
&В Newcomb,В A. (2012). Concomitant Epicardial
LeftВ Ventricular Lead Implantation in Cardiac Surgical
Patients with Impaired Cardiac Function. ANZSCTS
ASM, Hobart, Tasmania, Australia.
Goh, S., Prior, D., Newcomb, A. & Yii, M. (2012).
Proven Durability Of “Down-Under Repair” For
Ischaemic Mitral Regurgitation At 5-Year FollowUp. 20th Annual Meeting of The Asian Society
forВ Cardiovascular & Thoracic Surgery (ASCVTS),
Nusa Dua, Indonesia. March
Conaglen, P., Wilson, A. M. & Newcomb, A. E.
(2012). Insulin Resistance, Vaso-reactivity and
Nitric Oxide Metabolites in Patients Undergoing
Cardiac Surgery. Peter Ryan Prize PresentationSt Vincent’s Hospital Inaugural Surgical Forum,
Melbourne, Victoria, Australia. November
Goh, S., McLellan, A., Prior, D., Newcomb, A.,
Dimitriou, J., Rosalion, A., Nixon, I. & Yii, M. (2012).
Surgical Ventricular Restoration (SVR) Procedure:
AВ Single Centre Comparison of STICH vs NonSTICH Patients. Society of Thoracic Surgeons (STS),
Fort Lauderdale, USA. January
Hemingway, S., Edward, K., Warelow, P.,
Hercelinskyj, G., Welch, A., & McAndrew, S. (2012).
Careering forward: Why do people in Australia and
the UK choose for a career in mental health nursing?
2nd Horatio festival, Stockholm, 20–23 September
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Hofferberth, S.C., Newcomb, A.E., Yii, M.Y.,
Nixon,В I.K. & Mossop, P.J. (2012). Midterm
Outcomes of Combined Proximal Endografting
with Distal True Lumen Bare Metal Stenting
forВ Management of Type B Aortic Dissection.
ASCVTS, Nusa Dua, Indonesia. March
Hofferberth, S.C., Newcomb, A.E., Yii, M.Y.,
Nixon,В I.K. & Mossop, P.J. (2012).Combined
Proximal Stent Grafting Plus Distal Bare Metal
Stenting for Management of Aortic Dissection:
Superior to Standard Endovascular Repair?.
92ndВ Annual Meeting of the American Association
for Thoracic Surgery, San Francisco, USA. April
Hristov, E., Worrall-Carter, L., Daws, K.,
Edward,В K-L., Wilson, A., Rahman, M.A., Page, K.
(2012). Baseline data of a nurse-led risk intervention
screening clinic for cardiovascular disease.
Poster presented at St Vincent’s Research Week,
St Vincent’s Hospital Melbourne, Australia.
20–22 August
Kuhn, L., Page, K., Ward, J., Worrall-Carter,В L.
(2012). Risk factors for increased time to treatment
for acute myocardial infarction in Victorian
emergency departments: A regression-tree analysis.
10thВ International Conference for Emergency
Nursing for the College of Emergency Nursing
Australasia, Hobart, Australia. 10–13 October
McQuilten, Z., Andrianopoulos, N., Wood, E.,
Cole-Sinclair, M., McNeil, J., Cameron, P., Reid, C.,
Newcomb, A., Smith, J., Phillips, L. (2012). Wide
Variation in Transfusion Practice in Cardiac Surgery:
Results from the ANZSCTS Cardiac Surgery
Database, ANZSCTS ASM, Hobart, Tasmania,
Australia
McQuilten, Z., Enticott, J., Wood, E., Cole-Sinclair,В M.,
McNeil, J., Cameron, P., Reid,В C., Newcomb, A.,
Smith, J., Phillips, L. & Andrianopoulos, N. (2012).
Development of a Risk Prediction Model for Large
Volume Red Cell Transfusion in Cardiac Surgery.
Poster Presentation at ANZSCTS ASM, Hobart,
Tasmania, Australia
Naidu, P., Edward, K., Murphy, M., Gleeson, G.,
&В vanGaal, W. (2012). A Comparison of Mean Dtn
forВ Thrombolysis as Compared to Mean Dtb Time
For Primary Pci in the First 12 Months of a New
Cardiac Cath Lab. Annual Scientific Meeting of
the Cardiac Society of Australia and New Zealand,
Brisbane, 16–19 August
Newcomb, A. (2012). Minimally Invasive Conduit
Harvest. Invited Lecture. ANZSCTS ASM. Hobart,
Tasmania, Australia
Newcomb, A.E. (2012). Minimally Invasive Valve
Surgery. St Vincent’s Hospital Inaugural Surgical
Forum, Melbourne, Victoria, Australia. November
Punch, A., Daws, K., Willis, J., Winters, M.,
Posenelli, S., MacIsaac, A., Rahman, M.A.,
Worrall-Carter, L. (2012). Aboriginal patients
with acute coronary syndrome: diagnoses and
interventions at St Vincent’s Hospital Melbourne.
Moderated Oral Poster Presentation at St Vincent’s
Research Week, St Vincent’s Hospital Melbourne,
Australia. 20 August
Punch, A., Daws, K., Willis, J., Winters, M.,
Posenelli, S., MacIsaac, A., Rahman, M.A.,
Worrall-Carter, L. (2012). Aboriginal patients
with acute coronary syndrome: diagnoses and
interventions at St Vincent’s Hospital Melbourne.
Poster presented at St Vincent’s Research Week,
St Vincent’s Hospital Melbourne, Australia.
20–22 August
Scruth, E., Merz, N.B., Worrall-Carter, L.
&В Cheng,В E. (2012). Cardiovascular Risk Prediction
Tools in Women with STEMI undergoing PCI.
Poster presented at Women’s Health Conference,
Washington DC, USA. 16–18 March
Scruth, E., Worrall-Carter, L. & Cheng, E. (2012).
Use of risk scoring tools to determine risk of
secondary cardiac and non cardiac events during
hospitalization for ST Elevation Myocardial Infarction
in a cohort of women. Sigma Theta Tau International
Nursing Research Congress, Brisbane, Australia.
30 July–3 August
Shi, W.Y., Yap, C-H., Newcomb, A.E., Tran, L.,
Reid, C.M., Shardey, G.C. & Smith, J.A. (2012).
Impact of Socioeconomic Status and Rurality
on Early Outcomes and Mid term Survival after
CABG: Insights from a Multicentre Registry.
Poster Presentation at ANZSCTS ASM, Hobart,
Tasmania,В Australia
Ski, C.F. & Thompson, D.R. (2012). Motivational
interviewing in Cardiovascular Disease. Baker IDI
Staff training workshop, Alice Springs, Australia.
14В February
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Cardiovascular ResearchВ Centre
Ski, C.F. & Thompson, D.R. (2012). Motivational
interviewing in Cardiovascular Disease. Baker IDI
Staff training workshop, Alice Springs, Australia.
21В February
Ski, C.F. (2012). Clinical outcomes associated with
screening and referral for depression in an acute
cardiac ward. International Healthcare Conference
on Gender Issues and Evidence-Based Practice,
Chang Gung University of Science and Technology,
Taoyuan, Taiwan. 10 April.
Ski, C.F. (2012). Motivational interviewing in
cardiovascular health. National Conference, National
Cheng Kung University, Tainan, Taiwan. 13 April
Wilson, A. (2012). Prevention at St Vincent’s.
Grand Round, St Vincent’s Hospital, Melbourne,
Australia. 28 May
Worrall-Carter, L. (2012). An overview of Health
Outcomes Research in CVD at St Vincent’s
Melbourne. ACU Research Conversation Program,
Melbourne, Australia. 22 November
Worrall-Carter, L. (2012). Cardiovascular Nursing:
The future of our practice. Cardiovascular Nursing
Lecture at Cardiac Society of Australia and
NewВ Zealand 60th Annual Scientific Meeting,
Brisbane, Australia. 16–19 Aug
Thompson, D.R. (2012). Cardiac Rehabilitation:
How can it be improved? Prince Charles Hospital
Cadiology Division Seminar, Prince Charles Hospital,
Brisbane, Australia. 3 January
Thompson, D.R. (2012). Evaluating complex
interventions. International Healthcare Conference
on Gender Issues and Evidence-Based Practice,
Chang Gung University of Science and Technology,
Taoyuan, Taiwan. 10 April
Thompson, D.R. (2012). Psychosocial interventions
in coronary heart disease. National Conference,
National Cheng Kung University, Tainan, Taiwan.
13В April
Thompson, D.R. (2012). Psychosocial issues
inВ coronary heart disease. Prince Charles Hospital
Cadiology Division Seminar, Prince Charles Hospital,
Brisbane, Australia. 3 January
Thompson, D.R. (2012). Psychosocial research
inВ cardiovascular disease: interventions and
outcomes. ACU Research Conversation Program,
Melbourne, Australia. 22 November
Wang, W., Thompson, D.R., Ski, C.F., Lui,В M.
(2012). Health-related quality of life and its
associated factors in Chinese myocardial
infarctionВ patients. Healthcare Quality Forum,
Conrad Continental, Singapore. 30–31 March
Whitbourn, R. (2012). Renal denervation therapy:
Current and future platforms. Lecture at 6th Annual
Australia & New Zealand Endovascular Therapies
Meeting, Brisbane, Australia. 14–16 Aug
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Centre for Nursing Research
St Vincent’s Centre for Nursing Research
(SVCNR) undertakes research in specific
areasВ and programs that is based on improving
health outcomes and providing innovative
models of health care delivery. SVCNR
focuses on facilitating cross-disciplinary
andВ collaborative research.
About us
SVCNR promotes research leadership in the
areasВ ofВ cardiovascular research by increasing
research capacity of clinicians, academics and
higher degree students, as well as increasing
disease management awareness and health
education. The Centre aims to achieve excellence
inВ nursing and translational research.
The key areas of research at SVCNR:
• Prevention and Risk Management – Projects
in this area focus on risk factors associated with
cardiovascular disease (CVD), such as smoking
cessation and tobacco control, specific CVD
risk factors in women and Risk assessment
andВ prevention in ICU
• Depression & Anxiety – The project’s in this
area aim to improve depression, anxiety and
CVDВ modifiable risk factor profiles through
aВ nurse-led intervention
• Aboriginal Health – Projects in this area focus
on developing a greater understanding of
theВ experience and management of Aboriginal
peopleВ in acute cardiac settings and ultimately,
improving their health outcomes
The research projects at SVCNR are led by nurses
in collaboration with colleagues from a number of
health disciplines including medicine, public health,
as well as from the specialties of cardiology, mental
health, and chronic disease management.
Major projects
Projects
• Nurse-Led Risk Intervention Screening Clinic
(NL-RISC) – Completed
• Managing depression and anxiety risk
inВ thoseВ with cardiovascular disease:
A nurse-led intervention – Completed
• A secondary prevention patient centred model
for smoking cessation – Completed
• Strengthening Cardiac Care for Aboriginal and
Torres Strait Islander People with Acute Coronary
Syndrome – Completed
• Exploring Aboriginal patients’ experience of acute
cardiac care at St Vincent’s – Ongoing
• Cardiac Depression Scale (CDS) audit
– Implementing a depression pathway
forВ cardiacВ patients: An audit of its uptake
in the real-world – Completed
• Role of Dialysis – Nurse Practitioner Study
– Ongoing
Research highlights
• Prof Linda Worrall-Carter was awarded the
Cardiovascular Nursing Lecture at the Cardiac
Society of Australia and New Zealand’s 60th
Annual Scientific Meeting
• Dr Rahman was awarded ACU International
Conference Travel Grant to present SVCNR
research at Asian Pacific Society of Cardiology
Congress, Thailand
• Ms Punch received the best moderated oral
poster presentation at the St Vincent’s Research
Week at St Vincent’s Melbourne
• Ms Kuhn won the best student prize for
herВ PhDВ presentation at the Faculty of Health
Sciences Higher Degree Research Seminar
atВ ACU
Quality
During May 28–31, St Vincent’s hosted Prevention
Week, an event featuring daily activities designed
to raise awareness of cardiovascular disease (CVD)
prevention among patients, relatives and staff at St
Vincent’s Hospital Melbourne. Prevention Week was
organised by the Prevention group which is a part
CvRC. However SVCNR researchers held a “Know
Your Risk” stall where they offered blood pressure
and waist measurements, and information on CVD
risks, smoking cessation and healthy activity levels.
In October and November, SVCNR and
St Vincent’s Private Nursing Research Unit (NRU)
heldВ a fortnightly Clinical Research Workshop
inВ order toВ provide a research training program.
TheВ initiative was very well received, with over
50В people at each of the four sessions, which
were held at theВ Michael Chamberlin Theatre
at St Vincent’s. The workshop sessions guided
participants through the entire research process,
st vincent’s research report 2012
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Centre for Nursing Research
covering important topics such asВ the importance
of research, refining a research topic, methods
andВ data analysis, ethics submissions, recruitment,
as well as publication and final stages. There has
been a group of interested research nurses arise
from this workshop and more programs are to
beВ offered in the future.
Staff
Prof Linda Worrall-Carter, Director SVCNR
Dr Muhammad Aziz Rahman, Senior Research
Fellow (from April 2012)
Service to the wider community
Professor Linda Worrall-Carter
• Founding Member, Australasian Cardiovascular
Nurses College (ACNC)
• Founding Member, Cardiovascular Nurses Council
(CNC, CSANZ)
• Affiliate Member, Cardiac Society of Australia
andВ New Zealand (CSANZ)
• Member, Australian College of Critical Care Nurses
(ACCCN)
Ms Karen Daws, Research Fellow
• Member, Royal College of Nursing, Australia
(RCNA)
Ms Nasreen Jahan, Research Fellow
(fromВ OctoberВ 2012)
• Member, Australian Cardiovascular Health
andВ Rehabilitation Association (ACRA)
Ms Helen Venables, Research Assistant
(April–September 2012)
• Research Ambassador, Heart Foundation
Ms Katherine McQualter, Research Assistant
• Chair of the Nursing Program,
HeartВ FoundationВ National Conference 2011
Ms Christine Wright, Research Assistant
International Conference Chair:
Ms Shawana Andrews, Research Assistant
(fromВ May 2012)
Ms Verena Schadewaldt, Research Assistant
(untilВ August 2012)
• Member for the Heart Foundation
ScientificВ Program
Grant Review:
Ms Elizabeth Hristov, Research Assistant
(February–October 2012)
• Australian Research Council
Ms Sally Kemp, Research Assistant
(untilВ DecemberВ 2012)
• Heart Foundation of Australia
Ms Amanda Punch, Research Assistant
(untilВ AugustВ 2012)
Ms Tara O’Shea, Finance Officer
Ms Cynthia Estibeiro-Rathod,
AdministrativeВ Officer/ Receptionist
Ms Natalie Puchalski, Communications Officer
Ms Miriam Spano, Operations Manager
(untilВ AugustВ 2012)
Ms Megan Henst, Executive Assistant
(untilВ September 2012)
Students
Lisa Kuhn, PhD Student
Elizabeth Scruth, PhD Student
Malcolm Elliott, PhD Student
Alysia Coventry, Masters Student
• NHMRC
• International/ Killam Research Fellowship (Canada)
• Nurses Board of Victoria (NOT nurses board
anymore – needs changing as National)
Editorial Board Member:
• Nursing & Health Sciences
Manuscript Review:
• International Journal of Cardiology
• European Journal of Heart Failure
• Heart and Lung
• European Journal of Cardiovascular Nursing
• Journal of Cardiovascular Nursing (US)
• Australian Critical Care
• Contemporary Nurse
• Nursing & Health Sciences
st vincent’s research report 2012
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Centre for Nursing Research
Dr Muhammad Aziz Rahman
• Honorary Research Associate, National Centre for
Clinical Outcomes Research (NaCCOR), Australia
• Member, Victorian Association of Research Nurses
(VARN)
• Fellow, Royal Society of Public Health (FRSPH),
UK
• Member, Public Health Association of Australia
(PHAA), Australia
• Member, Bangladesh Medical and Dental Council
(BMDC), Bangladesh
Manuscript Review:
• Australian and New Zealand Journal
ofВ PublicВ Health
• PLoS One
• Journal of Public Health and Epidemiology
• Nursing and Health Sciences Journal
• Australian Critical Care
• Collegian
• African Journal of Biotechnology
Ms Nasreen Jahan
• Member, Public Health Association of Australia
(PHAA), Australia
• Member, Bangladesh Medical and Dental Council
(BMDC), Bangladesh
Ms Karen Daws
• Member, Australasian Cardiovascular Nurses
College (ACNC)
• Affiliate Member, Cardiac Society of Australia and
New Zealand (CSANZ)
Grants
Worrall-Carter L, Page K, Thompson D, Ski C,
Castle D, Whitbourn R, Salzberg M, & Wilson A.
Managing depression and anxiety risk in those with
cardiovascular disease: A Nurse Led Intervention,
beyondblue, Project Grant (HERDC category:
Research Grant/ Industry other contacts)
$120,760 for 2011–2013
Stanley, M., Langham, R., Rahman, M.A.
&В Worrall-Carter, L
Dialysis Nurse Practitioner Model of Care at
St. Vincent’s Hospital, Melbourne: 10 Years
ofВ activity, Australian and New Zealand Society
ofВ Nephrology
$10,000 for 2012–2013
Worrall-Carter, L., Tramm, R., Daws, K.,
Schadewaldt, V. & Prasad, M.
Implementing a depression pathway for cardiac
patients: An audit of its uptake in the real-world,
St Vincent’s Research Endowment Fund
$15,159 for 2012
Worrall-Carter, L., Page, K., Rolley, J.,
Thompson,В S., Daws, K., Leishman, M.,
McCarthy, S., Whitbourn, R., & MacIsaac, A.
Delivering best practice and education for
the contemporary cardiac catheter laboratory
environment, Medtronic / ACU Post-doctoral Clinical
Nursing Research Fellowship
$160,000 for 2012–2012
Page K, Rolley J X, MacIsaac A, Daws K,
WillisВ J,В Punch M, Winters M, Fergie D,
BelfrageВ M, Parker H, Henschke K, & Posenelli S.
Strengthenig cardiac care for Aboriginal and Torres
Strait Islander People with acute coronary syndrome,
Department of Health
$98,747 for 2011–2012
Collaborations in research
International
• University of Kentucky, Lexington, USA
• University of Pennsylvania, Philadelphia, USA
National
• Baker IDI Heart & Diabetes Institute,
Melbourne,В Victoria
• Box Hill Hospital, Box Hill, Victoria
• Cardiovascular Research Centre (CvRC),
Melbourne, Australia
• Curtin University of Technology, Perth,
WesternВ Australia
• Deakin University, Burwood, Victoria
• Department of Human Services,
Melbourne,В Victoria
• Monash University, Victoria
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Centre for Nursing Research
• St Vincent’s Private Melbourne, Victoria
• The Heart Foundation, Melbourne, Victoria
• University of Western Sydney, New South Wales
Publications
Journal articles
Buck, H. G., Lee, C. S., Moser, D. K., Albert, N.
M., Lennie, T., Bentley, B., Worrall-Carter, L.,
&В Riegel,В B. (2012). Relationship between self-care
and health-related quality of life in older adults with
moderate to advanced heart failure. Journal of
Cardiovascular Nursing, 27(1):8–15.
Elliott, M. (2012). Using ICU readmissions
asВ aВ marker of care quality: time for a rethink?
British Journal of Intensive Care, 22(3):23–26.
Elliott, M., Coventry, A. (2012) Critical care:
TheВ eight vital signs of patient monitoring.
British Journal of Nursing, 21(10):621–625.
Elliott, M., Page, K., & Worrall-Carter, L. (2012).
Reason’s accident causation model: Application to
adverse events in acute care. Contemporary Nurse,
43(1):14–20.
Mills, C., Newell, C. & Wright, C. (2012). Care
ofВ theВ post percutaneous coronary intervention
patient. Australian Nursing Journal, 19(7):26–27.
Rahman, M.A., Spurrier, N., Mahmood, M.A.,
Rahman, M., Choudhury, S.R., Leeder, S. (2012).
Choice of controls for a case-control study in
Bangladesh: Hospital controls vs. Community
controls. Asian Journal of Epidemiology, 5(3):75–86.
Scruth, E., Page, K., Cheng, E., Campbell, M., &
Worrall-Carter, L. (2012). Risk determination after
an Acute Myocardial Infarction: Review of clinical
risk prediction tools for the Clinical Nurse Specialist.
Clinical Nurse Specialist Journal, 26(1):35–41.
Scruth, E., Worrall-Carter, L., Cheng, E., Page,
K. (2012). Profiles of primary cardiovascular risk
in STEMI: How do these differ between men
andВ women? Primary Care Cardiovascular Journal,
5(4):176–180.
Scruth, E., Worrall-Carter, L., Cheng, E., Rolley, J.
& Page, K. (2012). Assessing risk post intervention
for an acute coronary syndrome: A review of the
risk assessment tools and their development.
Contemporary Nurse Journal, 43(1):2–13.
Ski, C., Page, K., Thompson, D., Cummins,В R.,
Salzberg, M., & Worrall-Carter, L. (2012).
Clinical outcomes associated with screening and
referral for depression in an acute cardiac ward.
Journal of Clinical Nursing, 21(15–16):2228–2234.
Worrall-Carter, L., Edward, K. & Page, K. (2012).
Women and cardiovascular disease: At a social
disadvantage? Collegian, 19(1):33–37.
Worrall-Carter, L., Ski, C., Thompson, D.,
Davidson, P., Cameron, J., Castle, D., & Page,
K. (2012). Recognition and referral of depression
inВ patients with heart disease. European Journal
of Cardiovascular Nursing, 11(2):231–238.
Speaking engagements
Daws, K. (2012). Secondary Prevention at a NurseLed Clinic. Grand Round, St Vincent’s Hospital
Melbourne, Australia. 28 May
Daws, K. (2012). The Architecture of St Vincent’s:
A preliminary review 1889–1931. St Vincent’s Nurse
Education Series, 10 May
Daws, K., McQualter, K. & Wright, C. (2012).
SVCNR current research projects. Presentation
toВ Cardiothoracic Care Centre nursing staff,
St Vincent’s Hospital, Melbourne, Australia. 5 March
Daws, K., Punch, A., Willis, J., Winters, M.,
Posenelli, S., Belfrage, M., MacIsaac, A., McDonald,
L. & Worrall- Carter, L. (2012). It’s not rocket
science – small changes that make a really big
difference to health outcomes for Aboriginal patients.
Victorian Aboriginal Health Conference 2012,
Melbourne, Australia. 24–25 May
Daws, K., Worrall-Carter, L., Hristov, E., Rahman,
M.A., Wilson, A. (2012). Adherence to secondary
prevention medication guidelines for cardiovascular
disease: Baseline data from a nurse-led risk
intervention screening clinic. Poster presented at
St Vincent’s Research Week, St Vincent’s Hospital
Melbourne, Australia. 20–22 August
Elliott, M. (2012). PhD presentation. Faculty of
Health Sciences Higher Degree Research Seminar,
ACU, Melbourne, Australia. 10 December
st vincent’s research report 2012
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Centre for Nursing Research
Hristov, E., Worrall-Carter, L., Daws, K.,
Edward,В K-L., Wilson, A., Rahman, M.A., Page, K.
(2012). Baseline data of a nurse-led risk intervention
screening clinic for cardiovascular disease.
Poster presented at St Vincent’s Research Week,
St Vincent’s Melbourne, Australia. 20–22 August
Scruth, E. (2012). Secondary risk for a cardiac
event in men and women presenting with an STEMI
and treated with PCI. Paper presented to Northern
California Heart Failure Physicians Group: The
Permanente Medical Group, Santa Clara, California,
USA. March
Kuhn, L. (2012). Guest speaker at Heart Foundation
(Victoria) forum: What happens when people go
to emergency with heart problems? Melbourne,
Australia. 5 December
Scruth, E. (2012). Secondary risk tools and
their useВ to stratify risk in patients with a primary
diagnosis of STEMI and treated with PCI. American
Lung Association Critical Care Nursing Symposium,
Nevada, USA. March
Kuhn, L. (2012). Guest speaker at Women’s Health
Victoria & Heart Foundation (Victoria) forum: Women,
Inequity and Heart Disease, Melbourne, Australia.
27В June
Kuhn, L. (2012). PhD presentation. Winner Student
Prize for Concurrent Session. Faculty of Health
Sciences Higher Degree Research Seminar, ACU,
Melbourne, Australia. 10 December
Kuhn, L. (2012). Women’s Heart Disease. Invited
lecture for Graduate Diploma of Intensive Care
andВ Graduate Diploma of Coronary Care students
atВ Deakin University, Melbourne, Australia. 3 May
Kuhn, L., Page, K., Ward, J., Worrall-Carter,В L.
(2012). Risk factors for increased time to treatment
for acute myocardial infarction in Victorian
emergencyВ departments: A regression-tree analysis.
10th International Conference for Emergency
Nursing for the College of Emergency Nursing
Australasia, Hobart, Australia. 10–13 October
Punch, A., Daws, K., Willis, J., Winters, M.,
Posenelli, S., MacIsaac, A., Rahman, M.A.,
Worrall-Carter, L. (2012). Aboriginal patients
with acute coronary syndrome: diagnoses and
interventions at St Vincent’s Hospital Melbourne.
Moderated Oral Poster Presentation at St Vincent’s
Research Week, St Vincent’s Hospital Melbourne,
Australia. 20 August
Scruth, E. (2012). Using risk tools to determine
secondary risk of cardiac events post PCI for STEMI.
31st Annual High Sierra Critical Care Conference,
Reno, Nevada, USA. 12–14 March
Scruth, E., Merz, N.B., Cheng, E., & WorrallCarter, L. (2012). Cardiovascular Risk Prediction
Tools in Women with STEMI undergoing PCI.
Poster presented at Women’s Health Conference,
Washington DC, USA. 16–18 March
Scruth, E., Worrall-Carter, L. & Cheng, E. (2012).
Use of risk scoring tools to determine risk of
secondary cardiac and non cardiac events during
hospitalization for ST Elevation Myocardial Infarction
in a cohort of women. Sigma Theta Tau International
Nursing Research Congress, Brisbane, Australia.
30 July–3 August
Worrall-Carter, L. (2012). An overview of Health
Outcomes Research in CVD at St Vincent’s
Melbourne. ACU Research Conversation Program,
Melbourne, Australia. 22 November
Worrall-Carter, L. (2012). Cardiovascular Nursing:
The future of our practice. Cardiovascular Nursing
Lecture at Cardiac Society of Australia and New
Zealand 60th Annual Scientific Meeting, Brisbane,
Australia. 16–19 August
Punch, A., Daws, K., Willis, J., Winters, M.,
Posenelli, S., MacIsaac, A., Rahman, M.A.,
Worrall-Carter, L. (2012). Aboriginal patients
with acute coronary syndrome: diagnoses and
interventions at St Vincent’s Hospital Melbourne.
Poster presented at St Vincent’s Research Week,
St Vincent’s Hospital Melbourne, Australia.
20–22 August
st vincent’s research report 2012
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Centre for Palliative Care
The Centre for Palliative Care (CPC) is part of
St Vincent’s Melbourne and is a Collaborative
Centre of The University of Melbourne, Australia.
The Centre has a statewide role in palliative
care education and research in Victoria, with
networks and collaborative projects extending
nationally and internationally.
About us
Research programs at the Centre are designed
to improve outcomes for both patients needing
palliative care and their family caregivers.
Investigations are carried out through strategic
partnerships with clinicians, academics, service
providers and government entities across Victoria,
Australia and internationally. We focus on three
research program areas:
• Palliative care provision – exploring systems
andВ approaches to improve direct care,
• Psychosocial support for families – focusing
onВ interventions to enhance psychosocial support
forВ family carers and
• Clinical studies – projects that examine
symptomВ management initiatives
Major projects
Cancer Care Trajectories
Funded by the Victorian Cancer Agency, this project
aimed to understand care trajectories of people with
prostate, breast, lung and haematological cancer
inВ Victoria. In 2012 the preliminary results have been
analysed and were presented at the Palliative Care
Victoria conference.
Understanding the Supportive and Palliative
Care Needs of People with Primary Malignant
Glioma and Their Carers
Family Carer Research
In 2012 a study was completed reducing distress
in family carers, funded by the National Health
andВ Medical Research Council.
Clinical tools to assist with specialist palliative
care provision
Funded by the Victorian Department of Health,
theВ aim of this project was to recommend key
clinicalВ tools to assist with care provision across
specialist palliative care settings. In 2012, results
of the project have been endorsed by the
VictorianВ Palliative Care Clinical Network.
Collaborations
CPC continued to contribute to the Palliative
CareВ Clinical Studies Collaborative through
theВ recruitment of patients to clinical trials;
theВ Palliative Care Research Network Victoria
hasВ continued to evolve with links with established
organisations, and CPC continues to auspice
theВ International Palliative Care Family Carer
Research Collaboration.
Quality
Bereavement Support Standards for Specialist
Palliative Care Services
In 2012, CPC developed bereavement support
standards for use in all Victorian governmentfunded, adult, specialist palliative care services.
InВ conjunction with the Australian Centre for Grief
and Bereavement, CPC developed these standards
through four methods:
• Consultation with key Australian and international
stakeholders using interviews, workshops, and
viaВ an expert advisory group
• A survey of all publicly funded Victorian palliative
care services
In 2012, this project completed data collection
and has begun disseminating findings, with several
publications expected to be published in 2013.
Further funding is being sought.
• A review of international evidence on the impact of
bereavement and bereavement interventions, and
Research Fellow Anna Collins was awarded the
Highly Commended award for her poster at the
2012 St Vincent’s Research Week, for her poster:
Utilising Hospital Administrative Datasets to Identify
Patterns of Service Use in Patients with a Primary
Malignant Glioma
The Bereavement Support Standards have been
widely disseminated and are available for download
on the CPC website.
• Adaptation and/or reference to key Australian
standards and guidelines.
st vincent’s research report 2012
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Centre for Palliative Care
Establishment of a new clinical service
Service to the wider community
Based upon the outcomes of research into the
needs of patients with chronic obstructive pulmonary
disease, a new clinical service was established
providing palliative care consultation into the end
stage respiratory clinics, with the aim to address
the identified patient needs. This service has been
mirrored into end stage renal and cardiac disease
clinics. The result has been enhanced clinical
services, publications and enhanced recruitment
toВ clinical studies.
Prof Peter Hudson
Staff
Prof Peter Hudson, Director 1.0EFT
A/Prof Jenny Philip, Deputy Director 0.4EFT
A/Prof Mark Boughey, Deputy Director 0.4EFT
Dr Anna Ugalde, Research Coordinator & Senior
Research Fellow 1.0 EFT (from Sept 2012)
Deborah Clark, Program Manager Research 0.8EFT
(until December 2012)
Kristina Thomas, research fellow (maternity leave)
0.4EFT
Dr Vijaya Sundararajan, Research advisor, 0.1EFT
Dr Adam Bostanci, Research Fellow 0.4 EFT
Dr Cheryl Remedios, Research Fellow 0.4EFT
Anna Collins, Research Fellow 0.6EFT
Lisa Willenberg, Research Assistant 0.2EFT
Catherine Duck, Research Nurse 0.6EFT
Anne Harbison, Research Nurse 0.6EFT
Rachel Allen, Research Administrative Assistant
1.0EFT (until October 2012)
Isabella Kelly, Research Administrative Assistant,
1.0EFT (from October 2012)
Alison Haitana, PA Director and Co-Deputy Director
1.0EFT
Karen Quinn, Education Coordinator/Project Officer
0.9 EFT
Students
• Member, Board of Directors, The International
Association of Hospice and Palliative Care
• Chair, Palliative Care Research Network Victoria,
management committee
• Chair, The International Palliative Care Family
CarerВ Research Collaboration
• Co-lead, European Association of Palliative Care
Taskforce aimed at enhancing support provided
toВ family carers.
• Academic advisor All Ireland Institute
ofВ HospiceВ Care
• Editorial advisor: Palliative Medicine
A/Prof Jenny Philip
• Member, Communication Facilitators’ Group,
Chapter of Palliative Medicine, RACP
• Member, Scientific Committee, Bethlehem Griffiths
Research Foundation
• Chair, Development of KPIs for palliative care
working group, Victorian Cooperative Oncology
Group, Cancer Council Victoria
• Member, Executive, Victorian Cooperative
Oncology Group, Cancer Council Victoria
• Member, Cancer Subcommittee of St Vincent’s
Research Cluster/Academic Centre
• Member, Palliative Medicine, Victorian Cooperative
Oncology Group, Cancer Council Victoria
• Chair, Hospital Consultative Advisory Committee,
reporting to Department of Health
• Chair, Hospital Consultative Minimum Data Set
Advisory Committee – reporting to Department
ofВ Health
• Member, Supportive Care Advisory Group,
Western Central Melbourne Integrated
CancerВ Service.
• Chair, Triage Working Group,
DepartmentВ ofВ Health, Victoria
Michael Chapman, PhD Student
Heather Lane, PhD Student
Bianca Devitt, MD Student
st vincent’s research report 2012
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Centre for Palliative Care
Dr Mark Boughey
Collaborations in research
• President elect – President, Chapter of Palliative
Medicine, RACP
International
• Council Member, Australian and New Zealand
Society of Palliative Medicine (ANZSPM)
• Palliative Medicine representative,
COAGВ NationalВ Reform Reference Group
• International Palliative Care Family Carer Research
Collaboration
• All Ireland Institute of Hospice Care
• Queen’s University, UK
• Chair and Clinical Lead, Victorian Palliative Care
Clinical Network (Department of Health)
National
• Member, Palliative Medicine Victorian Co-operative
Oncology Group
• Centre of Rural and Remote Mental Health,
University of Newcastle
• Member, Eastern Metropolitan Regional
PalliativeВ Care Consortia
• Western Australia Centre for Cancer
&В PalliativeВ Care
• Member, Catholic Healthcare Australia
PalliativeВ Care Special Interest Group
• Australian Centre for Grief and Bereavement
• Mental Health Service, St Vincent’s
Dr Anna Ugalde
• Medical Psychology Research Unit,
TheВ UniversityВ of Sydney
• Editor, Multinational Association for Supportive
Care in Cancer Society News
• Centre for Psychological & Behavioural Medicine,
Monash Medical Centre
• Executive Committee, The International Palliative
Care Family Carer Research Collaboration
• Victorian Government Department of Health
Grants
• Latrobe University
Jennifer Philip, Caroline Brand, CarolynВ Lethborg,
Vijaya Sundararajan, MichelleВ Gold, Michael
Murphy, Anna Collins, Gaye Moore
Understanding the supportive and palliative care
needs of patients with primary malignant glioma,
Victorian Cancer Agency
$331,870 for 2010–2012 ($61,540 in 2012)
Jennifer Philip, Tracey Weiland, George Jelinek,
Mark Boughey, Heather Lane, Jennifer Weil,
Claudia Marck
Improving emergency department care of patients
with advanced cancer, Victorian Comprehensive
Cancer Centre
$65,000 for 2012
Cheryl Remedios, Lisa Willenberg,
AndreaВ Murphy, David Agnew, Rachel Zordan,
Jennifer Philip
An Evaluation of Out-of-Home Respite Care
provided by Very Special Kids, VSK
50,135.70 for 2011–2012 ($30,000 in 2012)
• Monash University
• Austin Health
• Deakin University
• Barwon Health
• Swinburne University
• Peter MacCallum Cancer Centre
• Centre for Ethics in Society and Medicine,
TheВ Alfred Hospital
• Department of Clinical Epidemiology
andHealthServices Evaluation Unit,
RoyalMelbourneВ Hospital
• Flinders University – PaCCSC
• Queensland University of Technology
• Psycho-oncology Co-operative Research Group,
The University of Sydney
st vincent’s research report 2012
69
Centre for Palliative Care
Publications
Journal articles
De Lima, L., Bennett, M., Murray, S., Hudson,
P., Doyle, D., Bruera, E., Granda-Cameron,
C., Strasser,В F., Downing, J., Wenk, R. (2012).
International Association for Hospice and
Palliative Care (IAHPC) List of Essential Practices
in Palliative Care. Journal of Pain and Palliative
Care Pharmacotherapy. 26 (2), 118–122.
Fukui, M.,Iwase, S., Sakata, N., Kuroda, Y.,
Yoshjuchi, K., Nakagawa, K., Quinn, K., Hudson,В P.
(2012) Effectiveness of using clinical guidelines
forВ conducting palliative care family meetings in
Japan. Supportive Care in Cancer, 21(1), 53–58.
Hudson, P., Remedios, C., Zordan, R., Thomas,В K.,
Clifton, D., Crewdson, M., Hall, C., Trauer, T.,
Bolleter, A., Clarke, D.,, Bauld. C. (2012) Guidelines
for the Psychosocial and Bereavement Support
ofВ Family Caregivers of Palliative Care Patients.
Journal of Palliative Medicine, 15(6): 696–702.
Hudson, P., Lobb, E., Thomas, K., Zordan, R.,
Trauer, T., Quinn, K., Williams, A., Summers, M.
Supporting family caregivers of hospitalised palliative
care patients: effectiveness of a psycho-educational
group intervention. BMJ Supportive & Palliative Care,
2(2): 115–120.
Hudson, P., Lobb, E., Thomas, K., Zordan, R.,
Trauer, T., Quinn, K., Williams, A., Summers, M.
(2012). Psycho-educational group intervention
for family caregivers of hospitalized palliative care
patients: pilot study. Journal of Palliative Medicine,
15(3): 277–281.
Moore, G., Collins, A., Brand, C., Gold, M.,
Lethborg, C., Murphy, M., Sundararajan, V.,
Philip,В J. (2012) Palliative and supportive care needs
of patients with high-grade glioma and their carers:
A systematic review of qualitative literature. Patient
Education & Counseling, 91(2), 141–53.
Philip, J., Lowe, A., Gold, M., Brand, C., Miller, B.,
Douglass, J., Sundararajan, V. (2012) Palliative
care for patients with chronic obstructive pulmonary
disease: exploring the landscape. Internal Medical
Journal, 42(9), 1053–7.
Philip, J., Gold, M., Brand, C., Douglass, J.,
Miller,В B., Sundararajan, V. (2012) Negotiating hope
with chronic obstructive pulmonary disease patients:
a qualitative study of patients and healthcare
professionals. Internal Medicine Journal, 42(7),
816 – 822.
Weil, J., Gold, M., McIver, S., Rotstein, L., Philip,В J.
(2012) Australian resident doctors want more
palliative medicine education: a survey of attitudes
and perceived needs. Internal Medical Journal, 42(7)
828–30.
Bennett, M., Bruera, E., De Lima, L., Doyle, D.,
Downing, J., Granda-Cameron, C., Hudson,В P.,
Murray, S., Strasser, F., & Wenk, R. (2012)
International Association for Hospice and
Palliative Care (IAHPC) list of essential practices
in palliative care. Journal Of Pain & Palliative Care
Pharmacotherapy, 26(2):118–22.
Conference publications
Hudson P (2012) Multidisciplinary guidelines for
theВ psychosocial and bereavement support of family
caregivers of palliative care patients. Palliative Care
Congress, Montreal, Canada. 12 October 2012
Hudson P (2012) Supporting family caregivers
ofВ hospitalised palliative care patients: A psychoeducational group intervention. Palliative Care
Congress, Montreal, Canada. 12 October 2012
Hudson P (2012) Establishing a Research Network
for Victoria: preliminary achievements and insights.
Palliative Care Victoria Conference, Melbourne,
Australia. 23 August 2012
Nobel H, Kelly D & Hudson P (2012) Experiences
of carers supporting dying renal patients, managed
without dialysis. RCN Annual International Nursing
Research Conference, London, United Kingdom.
24В April 2012
Sundararajan, V. Utilising Hospital Administrative
Datasets to Identify Patterns of Service Use in
Patients with a Primary Malignant Glioma. The IPOS
14th World Congress and Psychosocial Academy,
Brisbane, Australia, 11–15 November 2012
st vincent’s research report 2012
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Centre for Palliative Care
Philip, J, Collins, A., Brand, C., Gold, M., Murphy,
M., Moore, G., Sundararajan, V., and Lethborg, C.
Understanding the Supportive and Palliative Care
Needs of People with Primary Malignant Glioma
andВ Their Carers. The IPOS 14th World Congress
and Psychosocial Academy, Brisbane, Australia,
11–15 November 2012
Collins, A. Utilising Hospital Administrative
DatasetsВ to Identify Patterns of Service Use
inВ Patients with a Primary Malignant Glioma.
19thВ International Congress of Palliative Care,
Montreal, 9–12 October 2012
Collins, A. Understanding the Supportive
and Palliative Care Needs of People with
Primary Malignant Glioma and Their Carers.
19th International Congress of Palliative Care,
Montreal, 9–12 October 2012
Philip, J. Understanding the Supportive and
Palliative Care Needs of Patients with Primary
Malignant Glioma: Views of Carers and Health
CareВ Professionals. 7th World Research Congress
ofВ the European Association of Palliative Care
(EAPC), Trondheim 7–9 June 2012
Philip, J. Utilising hospital administrative datasets
to identify patterns of service use in patients with
a primary malignant glioma. 7th World Research
Congress of the European Assocation of Palliative
Care (EAPC), Trondheim 7–9 June 2012
Philip, J. Understanding the Supportive and
Palliative Care Needs of People with Primary
Malignant Glioma and their Carers. Shaping
theВ Future ofВ Palliative Care Conference, Palliative
Care Victoria, Melbourne, 23–24 August 2012
Hudson P (2012) Preparing family caregivers for
their role: A program of intervention research. CECO
One day workshop, Newcastle-upon-tyne, United
Kingdom. 14 March 2012
Hudson P (2012) Palliative Care – Practice and
Principles. Specialist Certificate, Palliative Care
the Essentials, Melbourne University, Melbourne,
Australia. 23 February 2012
Hudson P (2012) Clinical practice guidelines for
the psychosocial & bereavement support of family
caregivers of palliative care patients. NASP Board
members, Melbourne, Australia. 16 February 2012
Philip J (2012) Ethical and legal considerations in
palliative care. University of Melbourne – Specialist
Certificate Program. Melbourne, 24 January 2012
Philip J (2012) The burden of symptoms of patients
with haematological malignancy. HAA-APSTH,
Melbourne, 28 October 2012
Philip J (2012) Second medical opinions: The views
of patients and their physicians. Communicating
Health Symposium, Melbourne, 4 December 2012
Ugalde A (2012) Barriers & enablers to being cared
for and dying at home with advanced cancer: what
does the research evidence tell us? Palliative Care
State-wide Forum 18 October 2012
Ugalde A (2012) Critical Appraisal of the Literature.
HAA-APSTH, Melbourne, 30 October 2012
Speaking engagements
Hudson P (2012) Family Centered Care. Specialist
Certificate, Palliative Care the Essentials, Melbourne
University, Melbourne, Australia. 7 September 2012
Hudson P (2012) Research in Palliative Care.
Specialist Certificate in Clinical Research, Melbourne
University, Melbourne, Australia. 10 July 2012
Hudson P (2012) Family Centered Care.
CabriniВ Education Program, Melbourne, Australia.
14В June 2012
st vincent’s research report 2012
71
Dermatology
The St Vincent’s Department of Dermatology
has seen major changes take place since the
last Research Report. Academic and strategic
relationships with Skin & Cancer Foundation
Inc and Peter MacCallum Cancer Centre have
been strengthened. The department’s focus has
shifted from laboratory to sub-specialty clinical
research. We facilitate clinical dermatologists
participating in medical research and undertake
clinical trials.
A/Prof Peter Foley, Specialist Dermatologist
About us
Dr Emma Veysey, Specialist Dermatologist
Dermatology is a branch of medicine that focuses
on diseases of the skin, its associated appendages,
including hairs and nails, and adjacent mucosal
surfaces including the genitals and the oral
cavity. Dermatology contains medical, surgical,
and aesthetic (cosmetic) aspects. Dermatology
at St Vincent’s is uniquely placed in Australia
with itsВ wide interest in subspecialty elements,
including, but not exclusively, cutaneous vasculitis,
ulcers (especially pyodermagangrenosum),
contact dermatitis, hidradenitssuppurativa,
photodermatology (photosensitivity disorders),
hairВ and scalp disorders, including alopecia,
psoriasis, immunobullous (autoimmune blistering)
disorders, skin cancer and cutaneous lymphoma.
We work collaboratively with other specialties
where interests overlap, including rheumatology,
haematology/oncology, plastic surgery and
gastroenterology/hepatology.
Dr Cara McDonald, Specialist Dermatologist
The St Vincent’s Dermatology team are actively
involved in clinical trials investigating safety and
effectiveness of new therapies – particularly new
medications, with a focus on the areas of psoriasis,
cutaneous lymphoma and skin cancer. Members
are actively engaged in the development and
implementation of teaching programs to disseminate
knowledge of skin disease to medical students,
general practitioners, dermatology registrars and
the broader dermatological community. Professor
Sinclair has relocated, but the department still
provides administrative and infrastructure support
toВ aВ number of his postgraduate students.
Dr Ellen Ma, Dermatology Registrar
Staff
Dr Anousha Yazdabadi, FRACD, ACD
A/Prof Christopher Baker, Specialist Dermatologist
Dr Sherine Fernando, PhD Student
A/Prof Christopher McCormack,
SpecialistВ Dermatologist
Dr Niloufar Torkamani, PhD Student
A/Prof Rosemary Nixon, Specialist Dermatologist
Dr Robert Kelly, Specialist Dermatologist
Dr Alvin Chong, Specialist Dermatologist
Dr Jack Green, Specialist Dermatologist
Dr Matheen Mohamed, Specialist Dermatologist
Dr Mei Tam, Specialist Dermatologist
Dr Adriene Lee, Specialist Dermatologist
Dr Helen Saunders, Specialist Dermatologist
Dr Alfonso Perez, Specialist Dermatologist
Dr Lee Mei Yap, Specialist Dermatologist
Dr Michelle Goh, Specialist Dermatologist
Dr Timothy O’Brien, Specialist Dermatologist
Dr Gordon Rennick, Specialist Dermatologist
Dr Aaron Boyce, Specialist Dermatologist
Dr Michelle Rodrigues, Specialist Dermatologist
Dr Belinda Welsh, Specialist Dermatologist
Dr Gayle Ross, Specialist Dermatologist
Dr Leona Yip, Specialist Dermatologist
Dr Yan Pan, Dermatology Registrar
Dr Alice Rudd, Dermatology Registrar
Dr Jonathan Ng, Dermatology Registrar
Dr Lauren Young, Dermatology Registrar
Dr Dallas Gramp, Dermatology Registrar
Dr Patrick Mahar, Dermatology Registrar
Dr Chris Jalilian, Dermatology Registrar
Dr Mark Cicchiello, Dermatology Registrar
Dr Vijaya Chitreddy, Dermatology Registrar
Ms Brenda Erjavec, Administration Officer,
Department of Dermatology
Students
Dr Zara Asgari, PhD Student
Dr Juan Lu
Dr Jani Li, PhD Student
st vincent’s research report 2012
72
Dermatology
Major projects
• A/Prof Peter Foley
Dr H Saunders – study at The Women’s: Topical
amitriptyline for treatment of vestibulodynia – a
double blind, randomised placebo controlled trial. • Board of Directors, Skin and Cancer Foundation
Service to the wider community
A/Prof Christopher Baker
• Scientific Research Committee, Australasian
College of Dermatologists
• Medial Subspecialty Committee, Australasian
College of Dermatologists
• Board of Directors, Skin and Cancer Foundation
• Academic Committee, Australasian College
ofВ Dermatologists
• Academic Committee, Australasian College
ofВ Dermatologists
• Board of Editorial Consultants, Medicine Today
• Pre-Eminent Academic Status Pathway
Assessment Committee, Australasian College
ofВ Dermatologists
• Steering Committee, Psoriasis Biologics Registry
• Australian Representative, PsoNet, European
Registries Project
• Member, GRAPPA (Group for Research and
Assessment of Psoriasis and Psoriatic Arthritis)
• Member, European Society for Photodermatology
• Editorial Board of the Latin American Psoriasis
andВ Psoriatic Arthritis Journal
• Editorial Board of Photodermatology,
Photoimmunology and Photomedicine Journal
• Editorial Board, Clinical Photodynamics
inВ Dermatology
• Editorial Board of the Journal of Photochemistry
and Photobiology B: Biology
• Editorial Board of the Latin American Psoriasis
andВ Psoriatic Arthritis Journal
• Board of Directors of the Photomedicine Society
• Member, European Society for Photodermatology
• The Cancer Council Australia National Skin
CancerВ Committee
• Australian Standards Committee CS-064 (Solaria)
• Steering Committee, Psoriasis Biologics Registry
A/Prof Christopher McCormack
• Steering Committee, GRAPPA
(GroupВ forВ Research and Assessment
ofВ PsoriasisВ andВ Psoriatic Arthritis)
• Victorian Cooperative Oncology Group Skin
Cancer Committee/CCV Clinical Network
SkinВ Cancer Committee
• Victorian Cooperative Oncology Group Skin
Cancer Committee/CCV Clinical Network
SkinВ Cancer Committee
• International dermatology working group
forВ Roche trials on vemurafenib
• Co-convenor of Raising Expectations in
Dermatology Meeting
A/Prof Rosemary Nixon
• Board of Directors, Skin and Cancer Foundation
• Co-convenor of Australian Progress
andВ PromiseВ Meeting
• Chair, Executive Committee, Victorian Faculty,
Australasian College of Dermatologists
• Medical Therapeutics Advisory Committee,
St Vincent’s Hospital Melbourne
• Medical Sub-speciality Committee, Australasian
College of Dermatologists
• Councillor, International Psoriasis Council
• Director, Occupational Dermatology Research
andВ Education Centre
• Member, International Contact Dermatitis
Research Group
• Editorial committee, Contact Dermatitis
• Executive Committee, Victorian Faculty,
Australasian College of Dermatologists
Dr Robert Kelly
• Executive Committee, Victorian Faculty,
Australasian College of Dermatologists
Dr Alvin Chong
• Victorian Cooperative Oncology Group Skin
Cancer Committee/CCV Clinical Network
SkinВ Cancer Committee
st vincent’s research report 2012
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Dermatology
Dr Mei Tam
• Board of Directors, Skin and Cancer Foundation
• Medical Director, Skin and Cancer Foundation
• Executive Committee, Victorian Faculty,
Australasian College of Dermatologists
• Rural and Regional Services Committee,
Australasian College of Dermatologists
Dr Adriene Lee
• Director of Training, Victorian Faculty,
AustralasianВ College of Dermatologists
• Executive Committee, Victorian Faculty,
Australasian College of Dermatologists
• National Training Committee,
AustralasianВ CollegeВ of Dermatologists
Dr Lee Mei Yap
• Executive Committee, Victorian Faculty,
Australasian College of Dermatologists
Dr Timothy O’Brien
• International Dermatology Outreach Committee,
Australasian College of Dermatologists
Dr Chris Jalilian
• Teaching, Learning and Curriculum Committee,
Australasian College of Dermatologists
Publications
Boyce AE, McGrath JA, Techanukul T, Murrell DF,
Chow CW, McGregor L, Warren LJ. Ectodermal
dysplasia-skin fragility syndrome due to a new
homozygous internal deletion mutation in the PKP1
gene. Australas J Dermatol. 2012 Feb;53(1):61–5.
Boyce AE, Dadzie OE, Flohr C. A solitary lesion
onВ the palmar aspect of the right middle finger
ofВ anВ 11 year old boy. PediatrDermatol. 2012
Jan–Feb;29(1):111–2.
Gramp D, Casey G, Kim YJ.Parotid fistula
complicating postauricular basal cellcarcinoma
excision. Australas J Dermatol.accepted 6 March
2012
Gunatheesan S, Tam MM, Tate B, Tversky J,
NixonВ R. Retrospective study of oral lichen
planusand allergy to spearmint oil. Australas
J Dermatol. 2012 Aug;53(3):224–8.
Boyapati A, Tam M, Tate B, Lee A, Palmer
A, Nixon R.Allergic contact dermatitis to
methylisothiazolinone: Exposure from baby
wipesВ causing hand dermatitis. Australas
JВ Dermatol. [Epub ahead of print]
Pan Y, Nixon RL. Allergic contact dermatitis
toВ topical preparations of bufexamac.
Australas J Dermatology 2012:53:207–210.
Nguyen R, Lee A. Allergic contact dermatitis caused
by isocyanates in resin jewellery. Contact Dermatitis
2012 July;67(1)56–57
Chow EC, Avolio AM, Lee A, Nixon R. Frequency
ofВ positive patch tests to preservatives: the
Australian experience. Australas J Dermatol
[EpubВ 2012 Oct 22]
Ng JC, Cumming S, Leung V, Chong AH. Accrual
of non-melanoma skin cancer in renal-transplant
recipients: Experience of a Victorian tertiary referral
institution. Aust. J. Dermatol. accepted 2012
Li J, Chong AH, O’Keefe R, Johnson PDR.
The fish tank strikes again – Metachronous
nontuberculous mycobacterial skin infection
inВ anВ immunosuppressed host. Aust. J. Dermatol.
accepted 2012
Li J, Chong AH, Green J, Baker C. Mycophenolate
use in dermatology: A Clinical Audit. Australas. J.
Dermatol. accepted 2012
Garcia-Doval I, Rustenbach SJ, Stern R, Dam TN,
Cohen AD, Baker C, Spuls PI, Naldi L. The Psonet
Network .Systemic psoriasis therapy shows high
between-countries variation. A sign of unwarranted
variation?Cross-sectional analysis of baseline data
from the Psonet registries. Br J Dermatol. accepted
2012 [Epub ahead of print]
Mahar PD, Foley PA, Sheed-Finck A, Baker CS.
Legal considerations of consent and privacy in the
context of clinical photography in Australian medical
practice. Med J Aust. accepted 2012 [EpubВ ahead
of print]
Baker C, Mack A, Cooper A, Fischer G, Shumack S,
Sidhu S, Soyer P, Wu J, Chan J, Nash P, Rawlin M,
Radulski B, Foley P. Treatment goals for moderate
toВ severe psoriasis: An Australian consensus.
Australas J Dermatol. accepted 2012 [Epub
aheadВ of print]
st vincent’s research report 2012
74
Dermatology
Baker CS, Foley PA, Braue A. Psoriasis uncovered
– measuring burden of disease impact in a survey
of Australians with psoriasis. Australas J Dermatol.
accepted 2012 [Epub ahead of print]
Ormerod AD, Augustin M, Baker C, Chosidow O,
Cohen AD, Dam TN, Garcia-Doval I, Lecluse LL,
Schmitt-Egenolf M, Spuls PI, Watson KD, NaldiВ L.
Challenges for synthesising data in a network
of registries for systemic psoriasis therapies.
Dermatology.2012;224(3):236–43.
McCurdy O, McCormack C, Ritchie D, Prince HM.
Exacerbation of lymphomatoid papulosis during
rituximab therapy. Australas J Dermatol. 2012
NovВ 29. [Epub ahead of print]
Lacouture ME, Duvic M, Hauschild A, Prieto VG,
Robert C, Schadendorf D, Kim CC, McCormackВ CJ,
Myskowski PL, Spleiss O, Trunzer K, Su F,В NelsonВ B,
Nolop KB, Grippo JF, Lee RJ, Klimek MJ, TroyВ JL,
Joe AK. Analysis of dermatologic events in
vemurafenib-treated patients with melanoma.
Oncologist. accepted 2012 [Epub ahead of print]
Shen S, O’Brien T, Yap LM, Prince HM,
McCormackВ CJ. The use of methotrexate in
dermatology: a review. Australas J Dermatol.
2012 Feb;53(1):1–18.
Batty LM, Lyon SM, Dowrick AS, Bailer M, Mahar
PD, Liew SM. Pulmonary embolism and the use
ofВ vena cava filters after major trauma. Australian
&В New Zealand Journal of Surgery 2012;82(11):
817–21.
Wasiak J, Mahar PD, Paul E, Menezes H,
Spinks AB, Cleland H. Inhaled methoxyflurane
for pain andВ anxiety relief during burn wound
care procedures: an Australian case series.
InternationalВ Wound Journal 2012; EPub
aheadВ ofВ print.
Mahar PD, Wasiak J, O’Loughlin C, Christelis N,
Arnold C, Spinks A, Danilla S. Frequency and
use ofВ pain assessment tools implemented in
randomized controlled trials in the adult burns
population: a systematic review. Burns 2012;
38: 147–54
Mahar PD. Only the best: medical student selection
in Australia. Comment. Medical Journal of Australia
2012;197(8):443
Wasiak J, Mahar P, McGuinness SK, Spinks A,
Danilla S, Cleland H. Intravenous lidocaine for
the treatment of background or procedural burn
pain. Cochrane Database of Systematic Reviews
2012;6:CD005622
Mahar PD, Wasiak J, Fowler S, Cleland H, Gruen
RL. Interventions for reducing wrong site surgery
and invasive procedures. Cochrane Database
ofВ Systematic Reviews 2012; 9: CD009404
Christensson JB, Andersen KE, Bruze M,
JohansenВ JD, Garcia-Bravo B, GimenezArnau A,
Goh CL, Nixon R, White IR. Air oxidised linaloolaВ frequent cause of fragrance contact allergy.
Contact Dermatitis 2012 67: 247–59.
Keegel T, MacFarlane E, Nixon RL, LaMontagne
AD. Provision of control measures for exposure
ofВ the hands to wet-working conditions in Australian
workplaces. Int Archives Occ Health 2012; 18:
313–19.
Gamboni SE, Allen KJ and Nixon RL. Infant feeding,
eczema and food allergies: A practical guide for
dermatologists. Accepted, Australas J Dermatol.
Epub ahead of publication Oct 2012
Lyons G, Keegel T, Palmer A, Cahill J, Nixon R.
Occupational dermatitis in hairdressers: do they
claim workers’ compensation? Contact Dermatitis
2012; 68:163–168
Gamboni SE, Nixon RL. Allergic contact
stomatitis to dodecyl gallate and a review of the
relevance of positive patch test results to gallates.
Accepted,В Australas J Dermatol. 2012; Epub ahead
of publication Sept 4
Bhahba F, Palmer A, Nixon R. Are reusable
rubberВ gloves associated with latex allergy?
Contact Dermatitis 2012; 67: 381–2
Keegel T, Nixon R, LaMontagneВ AD. Exposure to
wet-work in working Australians. Contact Dermatitis
2012; 66: 87–94
Bhaba F, Nixon R.Occupational exposure to
laboratory animals causing a severe exacerbation
ofВ atopic eczema. Australas J Dermatol 2012;
53:154–5
st vincent’s research report 2012
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Dermatology
De Cruz R, Horev L, Green J, Babay S, SladdenВ M,
Zlotogorski A, Sinclair R. A novel monilethrix
mutation in coil 2A of KRT86 causing autosomal
dominant monilethrix with incomplete penetrance.
Br J Dermatol. 2012 Jun;166Suppl 2:20–6.
Papp KA, Reid C, Foley P, Sinclair R, SalingerВ DH,
Williams G, Dong H, Krueger JG, Russell CB,
Martin DA. Anti-IL-17 Receptor Antibody AMG 827
Leads to Rapid Clinical Response in Subjects with
Moderate to Severe Psoriasis: Results from a Phase
I, Randomized, Placebo-Controlled Trial. J Invest
Dermatol.132:2466–9, 2012
Tan S, Sinclair C, Foley P. Running behind a
tourist: leisure-related skin cancer prophylaxis.
Br J Dermatol. 167 Suppl 2:70–5, 2012
Shen S, Williams RA, Kelly RI. Neuropathy in
aВ patient with lymphocytic thrombophilic arteritis
(pages e28–e32) Australas J Dermatol Article first
published online: 6 JAN 2012
Shen S, Kelly RI. Pharmacotherapy for Skin
Conditions in the Elderly. Journal of Pharmacy
Practice & Research 2012 Jun; 42 (2): 150–4.
Books
Foley P, Nash P. Healthworks: Psoriasis and Psoriatic
Arthritis. Published by Princeton Publishing Pty Ltd,
North Sydney NSW Australia 2012
Foley P, Radulski B. �Living With Psoriasis’ Patient
Information Booklet’. A patient educational booklet
developed in conjunction with Psoriasis Australia 2012
Book chapters
Baker C, Kelly R, Other Vascular DisordersIn:
Dermatology (3rd Edition) 2012, Bolognia, Jorizzo,
Rapini et al (editors), Elsevier
Lee A. Locksmiths. In Kanerva’s Occupational Skin
Diseases (2nd Ed) 2012, Rustemeyer T, Elsner P,
John SM, Maibach H (Eds), Springer Publishing
Lee A. Engravers. In Kanerva’s Occupational Skin
Diseases (2nd Ed) 2012 Rustemeyer T, Elsner P,
John SM, Maibach H (Eds), Springer Publishing
Nixon R. Allergic contact dermatitis and photoallergy.
In Lebwohl MG, Heymann WR, Berth-Jones
J, Coulson I. Eds Treatment of Skin Disease
Comprehensive therapeutic strategies. 3rd Edition.
SpringerВ 2012.В Sim M, Tan S, Nixon R. Malignant neoplasms
ofВ theВ skin. In Occupational Cancers.
Nixon R, Cahill J, Jolanki, R. Epoxy resins. In
Kanerva’s Occupational Skin Diseases (2nd Ed)
2012, Rustemeyer T, Elsner P, John SM, Maibach H
(Eds), Springer Publishing
Nixon R, Cahill J, Jolanki, R. Polyester resins.
In Kanerva’s Occupational Skin Diseases (2nd Ed)
2012, Rustemeyer T, Elsner P, John SM, Maibach H
(Eds), Springer Publishing
Presentations
Tam MM. Retrospective study of oral lichen planus.
Annual Scientific Meeting of the Australasian College
of Dermatologists. Brisbane, May 2012
Gunatheesan S. Retrospective study of oral lichen
planus and allergy to spearmint oil. Adrian Johnson
Award for 2012 for Shyamalar Gunatheesan. Annual
Scientific Meeting of the Australasian College
ofВ Dermatologists. Brisbane, May 2012
Boyapati A. Allergic contact dermatitis to
methylisothiazolinone: Exposure from baby
wipesВ causing hand dermatitis. John Fewings
prizeВ for best presentation for Annual Scientific
Meeting of theВ Australasian College of
Dermatologists. Brisbane, May 2012
Chong AH. A high incidence of skin cancers is
demonstrated in a population of renal transplant
recipients attending a dedicated transplant
dermatology clinic in Melbourne, Australia.
FiveВ yearВ prospective data.SCOPE (Skin cancer
in organ transplant recipients – Europe) Meeting,
May 2012, Istanbul, Turkey.
Chong AH. A survey of sun-related attitudesВ and
behaviours among Victorian renal transplant recipients.
SCOPE (Skin cancer in organ transplant recipients –
Europe) Meeting, May 2012, Istanbul, Turkey.
Lee A. Allergic contact dermatitis to
Methylisothiazolinone in Australia, 11th Congress
ofВ the European Society of Contact Dermatitis,
Malmo, Sweden June 2012
Nixon R. NHMRC seminar. Occupational contact
dermatitis: clinical perspectives and policy
translations. Alfred Hospital, December 2012
Nixon R. Skin cancer update. VMPF, Colac 2012
Nixon R. Occupational contact dermatitis: suspect
it, diagnose it, treat it! Monash University course
onВ occupational medicine, June 2012
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Dermatology
Nixon R. Skin cancer and occupational dermatitis:
what you should tell your grandchildren.
Guest speaker, Rotary Lunch, Windsor Hotel,
MelbourneВ 2012
Nixon R. Occupational contact dermatitis: suspect
it, diagnose it, treat it! Monash University course
onВ occupational medicine, June 2012
Nixon R. Hairdressers and occupational contact
dermatitis: do they claim workers compensation in
Victoria, Australia? 11th Congress of the European
Society of Contact Dermatitis, Malmo, Sweden
JuneВ 2012
Nixon R. Sunscreen allergy, Annual Scientific Meeting
of the Australasian College of Dermatologists.
Brisbane, May 2012
Nixon R. Allergic reactions to sunscreens. American
Contact Dermatitis Society, San Diego, March 2012
Nixon R. Cases from the coalface. Forum
onВ occupational skin disease prevention
convenedВ by Prof Swen John. American
AcademyВ ofВ Dermatology, Annual meeting,
SanВ Diego, MarchВ 2012
Foley P. What Screening, When, for Biologic
Use, Australian Dermatology Nurses Association,
Brisbane, May 2012
Foley P. Australian Psoriasis Treatment Goals
Project, Annual Scientific Meeting of the Australasian
College of Dermatologists. Brisbane, May 2012
Foley P. What’s new from the AAD, Annual
Scientific Meeting of the Australasian College
ofВ Dermatologists. Brisbane, May 2012
Foley P. Case Study Approach: Managing CoMorbidities in Difficult Psoriasis Patients, Annual
Scientific Meeting of the Australasian College
ofВ Dermatologists. Brisbane, May 2012
Foley P. Putting Telaprevir into Clinical Practice,
Brisbane, Sydney, Melbourne August, Adelaide
September, Perth October 2012
Foley P. Working up a patient with psoriasis for
biological therapy – Safety screening and treatment
choice, Australian Progress and Promise Meeting,
Sydney, August 2012
Foley P. Skin Malignancies in patients receiving
biologics: A Dermatology viewpoint, Australian
Progress and Promise Meeting, Sydney,
AugustВ 2012
Foley P. Optimising topical therapy for psoriasis,
New Zealand Dermatological Society Meeting,
Queenstown, August 2012
Foley P. Our common disease paradigm – insights
from dermatology, Melbourne, October 2012
Poster Presentations
Li J, Chong AH, Green J, Baker C. Mycophenolate
use in Dermatology – a clinical audit. SVHM
Research week, Aug 2012
Li J, Chong AH, O’Keefe R, Johnson PDR.
Case Report: The fish tank strikes again.
Metachronous atypical mycobacterial infection
in anВ immunocompromised host.Annual
Scientific Meeting of the Australasian College
ofВ Dermatologists. Brisbane, May 2012
Ng J, Chong AH. Atypical fibroxanthomaВ with
multipleВ local recurrences in a renal transplant
recipient. Annual Scientific Meeting of the
Australasian College of Dermatologists.
Brisbane,В May 2012
McCurdy O, Fahey V, Chong AH. Fatty acid
deficiency presenting as a NME like eruption
inВ aВ young Australian female.Annual Scientific
Meeting of the Australasian College of
Dermatologists. Brisbane, May 2012
Baker CS, Foley PA, Braue A. Psoriasis Uncovered:
The results of two quantitative surveys of psoriasis
patients in Australia.3rd World Psoriasis and Psoriatic
Arthritis Conference of the International Federation
of Psoriasis Associations, Stockholm, Sweden,
JulyВ 2012
GP and Professional Education
Chong A. Coordinator and Facilitator: Monash
University / Skin and Cancer Foundation Two
DayВ GP Skin Cancer workshop. March 2013
Chong A. Coordinator of the St Vincent’s Hospital /
Skin and Cancer Foundation GP Basic Management
of Skin Cancer Workshops. 2 Workshops run in 2012
– 2nd June 2012 SVHM, 4th August 2012 SACF
Mohamed M. Nonmelanoma Skin Cancer, Annual
RACGP Dermatology Update, Melbourne, May 2012
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Emergency Practice
Innovation Centre
St Vincent’s Emergency Practice Innovation
Centre (EPIcentre) supports multi-disciplinary
clinical and non-clinical research related to
emergency medicine.
About us
The EPIcentre seeks to make an important
contribution to the research and evidence base
inВ emergency medicine nationally and internationally,
including the prevention, diagnosis and management
of acute and urgent aspects ofВ illness and injury
affecting patients of all age groups with a full
spectrum of episodic undifferentiated physical
and behavioural disorders, and pre-hospital
andВ inhospital emergency medical systems.
InВ particular, it focuses on demand issues
inВ emergency medicineВ including public health
andВ prevention of chronic disease, and aspects
of emergency medicine relatively unique to the innercity Emergency Department (ED) at St Vincent’s
Hospital, including homelessness, mental illness,
behavioural problems, chronic illness and drug
andВ alcohol related illness. Research activities
adoptВ a broad approach, considering prevention
asВ well as factors influencing patient outcomes
bothВ within and outside of the ED.
Medical Education is also a focus area of the Centre,
with research being conducted into the learning
needs and structures of the emergency workforce.
The EPIcentre recognises the interactive nature
of emergency medicine with other specialty
areasВ and works in collaboration with many
relevantВ departments and services both internal
and external to St Vincent’s Hospital Melbourne.
Major projects
Projects conducted throughout 2012 include:
• Improving care of patients with advanced cancer
inВ the emergency department: A qualitative study.
In collaboration with St Vincent’s Centre for
Palliative Care, and funded by the VCCC, the study
will examine the proportion of patients who present
with cancer to the ED and their outcomes.
• Organ Donation: Understanding Family Decisions.
Funded by DonateLife and St Vincent’s activitybased funding, the study will involve interviewing
families whose loved one was a potential organ
donor to explore their experiences in making
donation decisions.
• Diagnosis of bacterial infections using non-invasive
specimens. In collaboration with the Nossal
Institute, and funded by CSIRO, our department
will recruit participants for an exciting proof of
concept study whereby breath samples will be
able to predict the presence and type of sepsis.
• Asylum seeker health and wellbeing: a scoping
study. St Vincent’s Health Australia funded a
systematic review of the literature and scoping
study of health services available for asylum
seekers in the community. More specifically,
thoseВ asylum seekers without access to Medicare,
in order to identify any gaps in services where
St Vincent’s could better assist. The project
involved collaboration with St Vincent’s social
workВ and the Brotherhood of St Laurence.
• Health Outcomes and Lifestyle in a Sample of
patients with Multiple Sclerosis (HOLISM) study.
Funded by the Bloom Foundation, this study will
examine people with MS and look at associations
between MS and lifestyle factors. Over 2000
responses have been gained from people with
MSВ taking part in a comprehensive online survey.
Other features/prizes/acknowledgements:
• Dr Georgina Phillips was awarded the �Teaching
Excellence Award’ by the Australasian College
for Emergency Medicine (ACEM) in 2012 for
herВ significant contribution towards international
emergency medicine and the teaching and
training of clinicians in the Pacific Islands and
Myanmar. Even though Georgina was an individual
recipient of the award (nominated by SVHM
colleagues), the award is also a recognition and
acknowledgement of St Vincent’s Melbourne as a
key site of international emergency care activities.
Quality
The results of a study examining IV sedation for
acutely agitated patients in ED (Chan EW, et al.
2013) were widely disseminated in the ED and
haveВ changed clinical practice. As many staff
wereВ heavily involved in the recruitment and data
gathering phases of this study, there was high
engagement and interest in the results. The study
showed that IV olanzapine was safe and effective
to use, and so it has now become an option for
theВ management of acutely disturbed patients in
the ED during a �Code Grey’ situation. Also, it is clear
that combination therapy (i.e. midazolam with either
droperidol or olanzapine) was more effective than
st vincent’s research report 2012
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Emergency Practice Innovation Centre
midazolam alone, so it is now standard teaching
in the ED and advised practice that combination
therapy is used in Code grey situationsВ to achieve
the rapid sedation of very agitated patients.
Dr Janelle Dalip, Registrar
These findings were also reflected in subsequent
changes made to the �Therapeutic Guidelines’
seriesВ in the area of sedating drugs for acutely
agitated patients.
Students
Dr Curtis Leacock, Registrar
Dr Hossein Sammei, Registrar
Ms Jane Varney, PhD candidate
Mr Grant Phillips, MNursing candidate
Staff
Ms Alexandra Cotter, Advanced Medical
ScienceВ Student
Prof George Jelinek, Director
Ms Nancy Khav, Advanced Medical Science Student
Dr Tracey Weiland, Senior Research Fellow
Ms Claudia Marck, Research Officer
Service to the wider community
Ms Emily Hadgkiss, Research Officer
Prof George Jelinek
Dr Dania van der Meer, Research Fellow
(fromВ MayВ 2012)
Staff with Honorary Appointments
withВ theВ University of Melbourne
Dr Jack Bergman, Senior Fellow
Dr Stuart Dilley, Senior Fellow
Dr Guy Sansom, Senior Fellow
Dr Craig Winter, Senior Fellow
Dr Michael Augello, Fellow
Dr Neil Cunningham, Fellow
Dr Nicola Cunningham, Fellow
Dr Jonty Karro, Fellow
Dr Sandra Neate, Fellow
Dr Georgina Phillips, Fellow
Emergency Medicine clinical staff
whoВ areВ involved in research
Dr Andrew Walby, Director, (from February 2012)
Dr Jennie Hutton, Staff Specialist
Dr Tom Hoey, Staff Specialist
Dr Alex Swain, Staff Specialist
Dr Jaqueline Maplesden, Staff Specialist
Dr Kirsten Cassidy, Staff Specialist
Dr Sarah Ward, Staff Specialist
Dr Steve Parnis, Staff Specialist
Dr Simon Walsh, Staff Specialist
Dr Leonie Marcus, Staff Specialist
Ms Susan Cowling, Nurse Unit Manager
• Chair of Human Research Ethics Committee –
A (HREC-A) at St Vincent’s Hospital Melbourne
• Emeritus Editor for the journal
EmergencyВ Medicine Australasia
• Group Leader at The Gawler Foundation.
Dr Tracey Weiland.
• Statistical Consultant for the journal
EmergencyВ Medicine Australasia.
Dr Georgina Phillips
• Deputy Chair of Human Research Ethics
Committee – A (HREC-A) at St Vincent’s Hospital,
Melbourne
• National Steering Committee Member of �Social
Justice Through Health – Homeless Health and
Wellbeing’ St Vincent’s Health Australia
• Committee of Management Member, St Vincent’s
Pacific Health Fund, St Vincent’s Hospital,
Melbourne
• Secretary, Senior Medical Staff Executive
Committee, St Vincent’s Hospital, Melbourne
• Member, Public Health Committee, Australasian
College for Emergency Medicine
• Member, International Development Grant Fund
committee, ACEM
• Pacific Islands and Myanmar representative,
International Emergency Medicine Special
InterestВ Group, ACEM
• Chair, Committee of Management, Project
Respect (small NGO working with women
inВ theВ sex industry and who have been trafficked
into Australia; www.projectrespect.org.au )
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Emergency Practice Innovation Centre
Susan Cowling, Margaret Maslin
andВ BelindaВ Casboult
• Visited the Port Moresby General Hospital
Emergency Department in order to support/train
local staff as part of the �Nursing Capacity Building
in PNG’ funded by ACEM
Grants
Jelinek GA.
Measuring adherence to lifestyle modification and its
correlation with quality of life outcomes for patients
with multiple sclerosis, Linda and Tony Bloom
Foundation
$40,000 for 2010–2012 ($13,000 in 2012)
Jelinek GA, Boughey M, Weil J, Philip J, Weiland
TJ, Lane H, Haydon A.
The care of patients with advanced cancer in the
emergency department – exploring opportunities
toВ improve care, Victorian Cancer Agency
$76,000 for 2011–2012 ($51,000 in 2012)
Jelinek GA.
The care of patients with advanced cancer in the
emergency department – exploring opportunities to
improve care, SVHM – Research Endowment Fund
$36,441 for 2012
Varney J, Weiland TJ, Jelinek GA, Inder W and
Liew D.
Cost-Effectiveness of a telephone coaching
intervention for patients with poorly controlled Type
2 Diabetes., SVHM – Research Endowment Fund
$14,992 for 2011–2012 ($7,496 in 2012)
Jelinek GA, Hadgkiss E.
Health Outcomes and Lifestyle in a Sample
ofВ patients with Multiple Sclerosis (HOLISM),
LindaВ andВ Tony Bloom Foundation
$89,375 for 2012–2013 ($60,000 in 2012)
Hadgkiss E, Lethborg C, Al-Mousa A, Marck C.
Asylum seeker health and wellbeing: scoping study,
St Vincent’s Health Australia
$38,978 for 2012
Philip J, Weiland T, Boughey M, Jelinek G,
LaneВ H, Weil J, Knott J, Chiu A, Marck C.
Improving emergency department care of patients
with advanced cancer: A qualitative study,
VictorianВ Comprehensive Cancer Centre (VCCC)
$70,000 for 2012–2013 ($50,000 in 2012)
Weiland T, Jelinek GA, Marck CH, Neate S.
Organ donation: Understanding family decisions,
SVHM
$39,212 for 2011–2012($9,212 in 2012)
Phillips GA.
Nursing capacity building for emergency care in
PNG., Australasian College for Emergency Medicine,
International Development Fund.
$20,000 for 2012
Collaborations in research
National
• Royal Melbourne Hospital, Victoria
• Western Hospital, Victoria
• Sunshine Hospital, Victoria
• Royal Melbourne Institute of Technology,
Melbourne, Victoria
• Austin Health, Melbourne, Victoria
• The University of Melbourne, Victoria
• Monash University
• Australian Catholic University, Melbourne Victoria
• The Gawler Foundation, Yarra Valley, Victoria
• DonateLife, Australia
• Australasian College for Emergency Medicine
Publications
Books
Brown D, Grierson E, Jelinek G, Macarow K,
Samartzis P, Weiland T, Winter C. 2012. Designing
Sound for Health and Wellbeing. Australian Scholarly,
Melbourne, ISBN: 978–1–921875–62–5
Journal articles
Jelinek GA. (2012) The developing challenge of
clinical longevity. Emerg Med Australas 24(2): 201–2
Wong RE, Weiland TJ, Jelinek GA. (2012)
Emergency clinicians’ attitudes and decisions
inВ patient scenarios involving advance directives.
Emerg Med J 29(9):720–4.
Marck CH, Weiland TJ, Neate SL, Hickey BB,
Jelinek GA. (2012) Personal attitudes and beliefs
regarding organ and tissue donation: a crosssectional survey of Australian emergency department
clinicians. Prog Transplant 22(3):317–22.
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Emergency Practice Innovation Centre
Jelinek GA, Marck CH, Weiland TJ, Neate SL,
Hickey BB. (2012) Organ and tissue donation-related
attitudes, education and practices of emergency
department clinicians in Australia. Emerg Med
Australas 24(3):244–50.
Marck CH, Weiland TJ, Neate SL, Hickey BB,
Jelinek GA. (2012) Australian emergency doctors’
and nurses’ acceptance and knowledge regarding
brain death: a national survey. Clin Transplant 2012
26(3):E254–60.
Cunningham NJ, Weiland TJ, van Dijk J, PaddleВ P,
Shilkofski N, Cunningham NY. (2012) Telephone
referrals by junior doctors: a randomised controlled
trial assessing the impact of SBAR in a simulated
setting. Postgrad Med J 2012 Aug 14. doi:10.1136/
postgradmedj–2011–130719.
Moore G, Hepworth G, Weiland T, Manias E,
GerdtzВ MF, Kelaher M, Dunt D. (2012) Prospective
validation of a predictive model that identifies
homeless people at risk of re-presentation to
theВ emergency department. Australas Emerg
Nurs J 15(1):2–13.
Gerdtz MF, Weiland TJ, Jelinek GA, Mackinlay C,
HillВ N. (2012) Perspectives of emergency department
staff on the triage of mental health-related
presentations: implications for education, policy
and practice. Emerg Med Australas 24(5):492–500.
Neate SL, Marck CH, Weiland TJ, Cunningham N,
Hickey BB, Dwyer BM, Jelinek GA. (2012) Australian
emergency clinicians’ perceptions and use of the
GIVE Clinical Trigger for identification of potential
organ and tissue donors. Emerg Med Australas
24(5):501–09.
Jelinek GA, Hadgkiss E, Hassed C, Crimmins
B, Schattner P, Liew D, Kausman R, Inder
W, GutbrodВ S, Weiland TJ. (2012) Difficulties
in Recruitment for a Randomised Controlled
TrialВ of Lifestyle Intervention for Type 2 Diabetes:
Implications for Diabetes Management. Open
Journal of Endocrine and Metabolic Diseases
2:53–57.
Phillips GA, Hendrie J, Atua V, Manineng C. (2012)
Capacity building in emergency care: An example
from Madang, Papua New Guinea. Emerg Med
Australas 24(5):547–52.
Cunningham N. (2012) The medicolegal issues
surrounding body pushers, packers and stuffers.
Emergency Medicine Australasia 24:590–4.
Cunningham N. (2012) Sexual assault consultations –
From high risk to high reliability. J Forensic Leg Med
19:53–9.
Conference publications
Jelinek GA. �Patients with advanced cancer in
Australian emergency departments’, Conference
Proceedings of the 29th Annual Scientific Meeting,
Australasian College for Emergency Medicine,
Hobart, November 2012
Jelinek GA. �Why public health in the ED is good
for you and your patients’, Conference Proceedings
of the 29th Annual Scientific Meeting, Australasian
College for Emergency Medicine, Hobart,
NovemberВ 2012
Weiland TJ, Nguyen M, Jelinek GA. (2012)
Illness perception and knowledge with regard
toВ prediabetes and type 2 diabetes: a pilot study
of emergency department patients and staff.
Eur J Emerg Med 19(6):353–8.
Dalip J, Phillips GA, Jelinek GA, Weiland TJ. (2012)
Can the elderly handle the heat? A retrospective
case-control study of the impact of heatwaves
onВ older patients attending an inner city Australian
emergency department. Asia-Pacific J Pub Health
Dec 4, doi: 10.1177/1010539512466428
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Emergency Practice Innovation Centre
Speaking engagements
Marck CH, Neate SL. �Assessing Barriers to Organ
and Tissue Donation in Emergency Departments’,
DonateLife national forum, Brisbane, March 2012
Jelinek GA. �What’s Important? Insights from one
Academic’s Career Path’, Annual Doctors Research
Forum, Centre for Palliative Care, University of
Melbourne, May 2012
Phillips GA. Myanmar Emergency Medicine
Introductory Course (MEMIC), sponsored by
the Australian Ambassadors Direct Aid Program
(Australian Agency for International Development),
Yangon, Myanmar, June 2012
Stevens B, Cowling SA. �Starting resuscitation
in the B.A.R. – a first at St Vincent’s’, 14th
International Conference on Emergency
Medicine,В Dublin, June 2012
Phillips GA. �Emergency Medicine in Myanmar’,
�Innovate Forum’, St Vincent’s Hospital, Melbourne,
July 2012
Marck CH. �Assessing Barriers to Organ and Tissue
Donation in Emergency Departments’, International
Congress of The Transplantation Society, Berlin,
JulyВ 2012
Marck CH. �Australian Emergency Clinicians’
Acceptance and Knowledge Regarding Brain Death:
a National Survey’, St Vincent’s Hospital Melbourne
Research Week, August 2012
Phillips GA. �Emergency Care in the Pacific; lessons
learnt and next steps & International emergency
care – training on the job’, International Emergency
Care Symposium, The Alfred Hospital, Melbourne,
September 2012
Jelinek GA. �Patients with advanced cancer in
Australian emergency departments’, 29th Annual
Scientific Meeting, Australasian College for
Emergency Medicine, Hobart, November 2012
Jelinek GA. �Why public health in the ED is good
for you and your patients’, 29th Annual Scientific
Meeting, Australasian College for Emergency
Medicine, Hobart, November 2012
Phillips GA. �Ethics of international EM work’,
29thВ Annual Scientific Meeting, Australasian College
for Emergency Medicine, Hobart, November 2012
st vincent’s research report 2012
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Endocrinology and Diabetes
St Vincent’s Department of Endocrinology
and Diabetes is actively involved inВ research
examining insulin resistance, islet transplantation,
the biology of cortisol action, pituitary disease,
the mechanisms regulating bone formation
and the factors related to the development and
progression of diabetes related complications.
About us
The Department is fortunate to be staffed
byВ members with diverse research interests.
Prof Richard MacIsaac is director of the Department
of Endocrinology & Diabetes. He took up this
position in August 2011. He is an internationally
recognised expect in the field related to the
development and progression of diabetes related
complications, especially diabetic nephropathy.
A/Prof Glenn Ward is Head of Diabetes Services.
HisВ research interest is in insulin secretion and action
and islet transplantation, and transitions in diabetes
care, through a network of collaborators in Victoria
and overseas.
The following are Research Fellows working towards
their postgraduate degrees in 2012: Dr Carmela
Caputo and Dr Sybil McAuley
Research fellows are Dr Jacqueline Walters,
DrВ Nirupa Sachihanandran and Dr Kylie McLachlan.
Research Scientists are Varuni Obeyesekere
andВ Judith Gooley. Anne Ferguson is manager
ofВ endocrine clinical trials. Ms Ferguson coordinates
a number of trials within the Department of
Endocrinology and is now assisted by research
nurse Elizabeth O’Meara.
Prof Frank Alford, although �officially’ retired,
is stillВ involved in an advisory capacity with the
research group. He has done pioneering work
inВ the fields of insulin resistance and management
ofВ pituitary conditions.
Major projects
Defining markers of early diabetic kidney disease.
Richard MacIsaac
Sybil McAuley, Glenn Ward, Alicia Jenkins,
Richard MacIsaac and David O’Neal
To determine whether 11ОІHSD1 and 11ОІHSD2
gene promoter methylation of peripheral blood
mononuclear cell is increased in subjects with
TypeВ 2В diabetes compared to control subjects
Warrick J Inder, Varuni R Obeyesekere,
ChristinaВ Jang and Richard Saffery
ОІ cell dysfunction increases the risk of New
OnsetВ Diabetes After Transplantation (NODAT)
Project with Karen Dwyer, Glenn Ward, Varuni R
Obeyesekere
Intrasellar pressure in non-functioning pituitary
macroadenomas: Gender differences and influence
on pituitary hormone deficiencies.
Carmela Caputo
Insulin pump therapy in type 1 diabetes:
VascularВ health, insulin pharmacokinetics
andВ glucose sensing
Sybil McAuley
Quality
The success of the Islet transplantation program, in
collaboration with St Vincent’s Institute, has resulted
in the availability of this innovative therapy to a small
group of �brittle’ type 1 diabetic patients who are at
serious risk from unpredictable life-threatening major
hypoglycaemia.
The outcomes of the clinical trial of Islet
Transplantation in �brittle’ type 1 patients are now
free of major life-threatening hypoglycaemia while
maintaining near-normal blood glucose control.
Three of them are now free of insulin injections.
Staff
Director, Prof Richard MacIsaac
Deputy Director, A/Prof Glenn Ward
A/Prof David O’Neal
A/Prof Alicia Jenkins
Dr Nirupa Sachihanandran, Research Fellow
Dr Kylie McLachlan, Research Fellow
Dr Carmela Caputo, Research Fellow
Dr Jacqueline Walters, Research Fellow
Prof Frank Alford, Emeritus Professor
Dr Caroline Jung. Research Fellow
Dr Sybil McAuley, Research Fellow
st vincent’s research report 2012
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Endocrinology and Diabetes
Judith Gooley, Research Scientist
Varuni Obeyesekere, Research scientist
Anne Ferguson, Research Nurse
Elizabeth O’Meara Research Nurse
Students
Sachithanandan N.
Observational Acromegaly Study, IPSEN
$67,600 for 4 years ($16,900 in 2011)
Sachithanandan N.
Pasireotide NETS Study, Novartis
$26,486 for 2 years ($13,000 in 2011)
Dr Sybil McAuley, Endocrinologist and MD Student
Collaborations in research
Service to the wider community
• Dr Richard MacIsaac: Menzies Institute, Darwin.
Mosaquies Diagnostics, Hannover, Germany
• Professor Richard MacIsaac, Chairman, Diabetes
Australia Research Trust Board. He also serves
on a number of expect panels including the
Australasian Proteinuria Consensus Working
Group. He also served on the 20011 NHMRC
endocrine grant review panel.
• Carmela Caputo: Novartis Victorian/Tasmanian
Pituitary Interest Group commenced September
2012. Aim to undertake collaborative projects
inВ 2013
Grants
Journal articles
MacIsaac R.
LEADER, Novo Nordisk
$191,620 for 5 years ($38,307 in 2011)
S Patel, B Wai, M Ord, R J MacIsaac, S Grant,
E Velkoska, S Panagiotopoulos, G Jerums, PM
Srivastava & LM Burrell. Association of ACE2
genetic variants with blood pressure, left ventricular
mass and cardiac function in caucaians with type
2В diabetes. American Journal of Hypertension, 2012,
25, 216–222.
Ward G, Jenkins A.
Metabolic monitoring of Islet transplantations,
Juvenile Diabetes Research Foundation
$400,000 for 4 years ($100,000 in 2011)
Ward G, Kay T.
Islet Transplantation at St Vincent’s, CCRE
$50,000
Ward G.
SAVOR, Astra-Zeneca
$49,390 for 5 years ($9,878 in 2011)
Ward G.
Trial Net, National Institute of Health
$5000
Dwyer K, Ward G, Jang C, Alford F.
β – Cell Dysfunction Increases The Risk Of New
Onset Diabetes After Transplantation, CARG:
Cellcept Australia Research Grant
$40,000
O’Neal D, McAuley S Ward G, MacIsaac R.
Basal Study, Roche NHMRC
$50,000
Publications
G Jerums, E Ekinci, S Panagiotopoulos
&В RВ JВ MacIsaac. Early glomerular filtration
loss as a marker of diabetic nephropahy.
European Nephropathy, 2012, 6, 33–37.
R J MacIsaac, G Jerums & GF Watts. Diabetic
chronic kidney disease. Diabetes: Chronic
Complications, 2012. Eds Shaw KM & Cummings
MH, John Wiley & Sons, LTD, London. Chapter 2,
34–66.
SK Patel, B Wai, R J MacIsaac, S Grant,
EВ Velkoska, Ord M, S Panagiotopoulos, G Jerums,
PM Srivastava, LM Burrel. The CTGF gene-945
G/C polymorphism is not associated with cardiac
or kidney complications in subjects with type 2
diabetes. Cardiovascular Diabetology 2012, 11:42.
ORIGIN Trial Investigators, Bosch J, Gerstein HC,
Dagenais GR, DГ­az R, Dyal L, Jung H, Maggiono AP,
Probstfield J, Ramachandran A, Riddle MC, RydГ©n
LE, Yusuf S. N-3 fatty acids and cardiovascular
outcomes in patients with dysglycemia. New
England Journal of Medicine, 2012, 367, 309–18.
st vincent’s research report 2012
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Endocrinology and Diabetes
ORIGIN Trial Investigators, Gerstein HC,
BoschВ J,В Dagenais GR, Jung H, Maggiono
AP, Pogue J, Probstfield J, Ramachandran A,
Riddle MC, RydГ©nВ LE, Yusuf S. Basal insulin
andВ cardiovascular and other outcomes in
dysglysaemia. New England Journal of Medicine,
2012, 367, 319–28.
Vu TD, VAradarajan S, Seeman E, Jerums G
& MacIsaac R J. Hypocalcaemia induced by
raloxifene. Current Drug Safety, 2012, 7, 176–178.
Johnson DW, Jones GR, Mathew TH, LudlowВ MJ,
Chadban SJ, Usherwood T, Polkinghorne K,
Colaggiuri S, Jerums G, MacIsaac R J, MartinВ H;
Australasian Proteinuria Consensus Working
Group. Chronic kidney disease and measurement
of albuminuria/proteinuria: a position statement.
Medical Journal of Australia, 197, 224–5.
So M, MacIsaac R J, Grossman M. Hypothyroidism:
investigation and management. Australia Family
Physician, 2012, 41, 556–562.
R J MacIsaac, El Ekinci, DJ Kelly & G Jerums.
New treatments for diabetic chronic kidney disease.
Journal of Nephrology and Therapeutics, 2012, S2,
doi: 10.4172/2161–0959. S2–006.
Maple-Brown LJ, Hughes JT, Lawton PD,
JonesВ GRD, Ellis AG, Katrina Drabsch K, Cass A,
Hoy WE, MacIsaac R J, O’Dea K & Jerums G.
Accurate assessment of kidney fuctionin Indigenous
Australians: the EGFR study. American Journal
of Kidney Diseases 2012, 60, 680–2.
Januszewski AS, Karschimkus C, Davis KER,
O’Neal D, Ward G & Jenkins AJ. Plasma 1,5
anhydroglucitol levels, a measure of short-term
glycaemia: assay assessment and lower levels
in diabetic vs. Non-diabetic subjects. Diabetes
Research and Clinical Practice 2012, 95, e17–e19.
High Incidence of Insulin Resistance and Dysglycemia
Amongst Nondiabetic Cardiac Surgical Patients.
Hofferberth SC, Newcomb AE, Ryan MC, Yii MY,
Nixon IK, Rosalion A, Boston RC, Ward GM &
Wilson AM. The Annals of Thoracic Surgery 2012,
94,117–122.
Vethakkan SR, Walters JM, Gooley JL, BostonВ RC,
Kay TWH, Goodman DJ, Jenkins AJ & Ward GM.
Normalized NEFA dynamics during an OGTT after
islet transplantation. Transplantation 2012, 94,
e49–51.
Dunning T, MacGinley R & Ward G. Is point of care
testing for anaemia (Hb) and microalbumin feasible
in people with type 2 diabetes attending diabetes
outpatient clinics? Renal Society of Australasia
Journal 2012, 8, 76–81.
Inder WJ, Obeyesekere VR, Jang C & Saffery R.
Evidence for transcript-specific epigenetic regulation
of glucocorticoid-stimulated skeletal muscle
11ОІ-hydroxysteroid dehydrogenase-1 activity in
typeВ 2 diabetes. Clinical Epigenetics 2012, 4:24.
ZГјrbig P, Jerums G, Hovind P, MacIsaac R J,
Mischak M, Neilsen SE, Panagiotopoulos S,
Persson F & Rossing R. Urinary proteomics
forВ earlyВ diagnosis in diabetic nephropathy.
Diabetes, 2012, 61, 3304–3313.
Sybil A. McAuley SA, Ward GM, HorsburghВ JC,
Jenkins AJ, MacIsaac R J & O’Neal DN.
TheВ evidence gap for clinical decisions regarding
insulin pump basal regimens. Infusystems Asia
2012, 7, 25–29.
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GASTROENTEROLOGY
The Department of Gastroenterology at
St Vincent’s Hospital Melbourne is the largest
gastroenterology department in Victoria
providing clinical care for patients with
aВ broad range of gastrointestinal disorders.
ItВ provides a comprehensive array of diagnostic
and therapeutic endoscopic procedures.
TheВ department undertakes clinical and
basicВ research into chronic viral hepatitis,
fattyВ liver disease, inflammatory bowel
disease and Barrett’s oesophagus.
About us
The research philosophy of the Department is to
undertake clinical, translational and basic research
centred around the clinical expertise and research
interests of department members. It provides a
comprehensive clinical service for inflammatory
bowel disease and also viral hepatitis. We have
aВ number of collaborations with researchers in
Victoria, throughout Australia and internationally.
Major projects
Inflammatory bowel disease research is coordinated
by Professor Michael Kamm and Dr Sally Bell.
TheВ research is currently looking at the causes
and treatment of recurrent Crohn’s disease after
bowel resection. The group has established aВ multicentre clinical trial of various therapeutic options
in patients who have undergone bowel resections
for active Crohn’s disease. The study also looks at
the changes in microbiota that may be responsible
for early recurrence of Crohn’s after surgery. The
group is also examining the incidence, prevalence
and natural history of inflammatory bowel disease
in a defined Australian population in the Barwon
district. Inflammatory bowel disease research
is alsoВ examining differences in prevalence and
naturalВ history of inflammatory bowel disease
inВ South East Asia and Australia. Finally this group
isВ examining the potential of faecal transplants
to alter the natural history of Crohn’s disease.
Research in Barrett’s Oesophagus is looking at
theВ diagnosis, staging and endoscopic treatment
ofВ people with severe dysplasia and early cancer
of the oesophagus associated with Barrett’s.
The hepatitis research group, headed by Dr Alex
Thompson and Associate Professor Paul Desmond,
is examining the natural history and treatment
outcomes for patients with chronic hepatitis B
andВ chronic hepatitis C. The studies are also
lookingВ at the role of genetics, particularly IL28B,
and response to treatment in chronic hepatitis C.
Other studies are examining the role of the innate
immune system in chronic hepatitis C, particularly
during treatment.
The Department participates in a large number
ofВ multi-national clinical trials for new agents
in theВ management of chronic viral hepatitis,
includingВ hepatitis C and hepatitis B, hepatocellular
carcinoma, Crohn’s disease and ulcerative colitis.
Quality
Recent publications by the Department will have
aВ significant impact related to the treatment
of chronic hepatitis C in relationship to IL28B
polymorphism. Studies on hepatitis B surface
antigen quantitation during treatment will also
haveВ an impact on the therapy of this disease.
Significant changes in inflammatory bowel disease
management and government resource allocation
is likely to come out of the incidence study recently
published by the Department.
Staff
A/Prof Paul Desmond, Director Department
ofВ Gastroenterology
Dr Sally Bell, Gastroenterologist
Prof Michael Kamm, Gastroenterologist
Dr Alex Thompson, Gastroenterologist
Dr Bill Connell, Gastroenterologist
Dr Stephen Brown, Gastroenterologist
Dr Andrew Taylor, Gastroenterologist
Dr Robert Chen, Gastroenterologist
Dr Marno Ryan, Gastroenterologist
Dr Mark Lust, Gastroenterologist
Dr Tin Nguyen, Gastroenterologist
Dr David Iser, Gastroenterologist
Nicole Tresize, Research Nurse
Kathryn Ritchie, Research Nurse
Katrina Dennis, Research Nurse
Lera O’Connor, Research Nurse
Bernadette De Graaff, Research Administrator
Amy Hamilton, Research Coordinator
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GASTROENTEROLOGY
Dr Jacqui Richmond, Research Nurse
Dr Mario Congiu, Research Scientist
Dr Mette Juulsgaard, Visiting International Research
Scholar
Dr David Ong, Visiting International Research
Scholar
Dr Prayman Sattianayagam, Visiting International
Research Scholar
Dr Edwin Verschuren, Visiting Internal Research
Scholar
Students
Dr David Iser, PhD
Dr Peter De Cruz, PhD
Dr Chat Jayasekera, MD
Dr Lani Prideaux, PhD
Dr Jacinta Holmes, PhD
Dr Georgina Cameron, MD
Theses passed in 2012
Dr Chat Jayasekera, MD,
TheВ UniversityВ ofВ Melbourne
Dr David Iser, PhD, The University of Melbourne
Grants
The role of ITPA genotype in pegylated-interferon
therapy for chronic hepatitis B., SVH Research
Endowment Fund
$20,000 in 2012
A/Prof Paul Desmond
Study of ABT-450/Ritonavir/ABT-267 and ABT-333
with Ribavirin in treatment experienced adults with
Genotype 1Hepatitic C virus, AbbVie Pty Ltd
AUD $111,000 for 2012–2014 (based on
10В enrolledВ subjects) (nil in 2012)
A/Prof Paul Desmond
Study of ABT-450/Ritonavir/ABT-267 and ABT-333
with Ribavirin compared to Telaprevir +PegInterferon
and Ribavirin in treatment naГЇve adults with
Genotype 1Hepatitic C virus, AbbVie Pty Ltd
$166,000 for 2013–2015 (based on 15 enrolled
subjects) (nil in 2012)
A/Prof Paul Desmond
Study of ABT-450/Ritonavir/ABT-267 and ABT-333
with Ribavirin in treatment experienced adults with
Genotype 1Hepatitic C virus, AbbVie Pty Ltd
$133,000 for 2013–2015 (based on 12 enrolled
subjects) (nil in 2012)
Dr Alex Thompson
Study of Peginterferon Lambda-1a +/- daclatasvir
+ribavirin compared to Peginterferon + ribavirin
for treatment naГЇve Genotype 2 and 3 adults
withВ Hepatitis C (017), Bristol Myers Squibb
$54.000 for 2012–2014 (based on 6 enrolled
subjects) ($22,000 in 2012)
Dr Alex Thompson
Study of Daclatasvir + Peginterferon + ribavirin
compared to Telaprevir + Peginterferon + ribavirin
forВ treatment naГЇve Genotype 1 adults with
HepatitisВ C (052), Bristol Myers Squibb
$62,000 for 2012–2014 (based on 6 enrolled
subjects) ($23,000 in 2012)
Dr Alex Thompson
Study of Asunaprevir and Daclatasvir and ribavirin
for null/partial responders to Peginterferon +
Ribavirin treatment, or those intolerant/ineligible
forВ peginterferon+ ribavirin treatment, Genotype 1b
adults with Hepatitis C (028), Bristol Myers Squibb
$63,800 for 2012–2014 (based on 6 enrolled
subjects) ($35,000 in 2012)
Dr Alex Thompson
Re-treatment study with Peginterferon Alfa-2a,
ribavirin and BMS-790052 with or without BMS650032 for subjects requiring rescue therapy having
participated in the 028 study.,, Bristol Myers Squibb
$14,000 for 2012–2014 (based on 2 enrolled
subjects) (nil in 2012)
A/Prof Paul Desmond
Evaluation of Tenofovir versus Adefovir Dipivoxil
treatment for presumed precore mutant chronic
HepВ B (0102) and HBeAg positive chronic Hep B
(0103), Gilead Sciences
Commenced 2005, follow-up continuing until 2015
($4,400 in 2012)
Dr Alex Thompson
Evaluation of response guided therapy of GS-5885
with or without GS-9451plus Peginterferon plus
ribavirin in Genotype 1 subjects with chronic HCV
(0148), Gilead Sciences
$92,000 for 2011–2013 (based on 8 subjects)
($35,000 in 2012)
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GASTROENTEROLOGY
Dr Alex Thompson
Evaluation of GS-7977 plus ribavirin for 12 weeks
in Genotype 2 or 3 subjects with chronic HCV who
are interferon intolerant/ineligible or unwilling (0107),
Gilead Sciences
$72,000 for 2012–2013 (based on 10 subjects)
($3,000 in 2012)
Stephen Locarnini, Nadia Warner,
AlexВ Thompson, Kumar Visvanathan.
Antiviral Drug Resistant HBV: Pathogenic
andВ Oncogenic Significance of the Altered Viral
Envelope, NHMRC Project grant_1011024
$525,390 for 3 years ($178,000 in 2012)
Dr Alex Thompson
A whole genome association study
forВ determinantsВ of clinical outcome and
treatmentВ response in chronic hepatitis C,
NH&MRC,В Overseas Biomedical Fellowship
$343,872 for 3 years ($114,200 in 2012)
Dr Alex Thompson
The GUIDE study, an investigator-initiated study
of IL28B genotype frequency among genotype
2/3 HCV-infected Australians, MSD Australia,
Unrestricted educational grant from MSD Australia
$120,000 in 2012
These include: NHMRC: fellow scholarship;
Charitable body grants: Gutsy Group $80,000,
Broad Foundation
Prof Michael Kamm
Practitioner Fellowship, NHMRC
$650,000 for 5 years ($125,000 in 2012)
Dr Peter DeCruz
NHMRC Scholarship
$95,000 for 3 years ($31,000 in 2012)
Prof Michael Kamm
Recurrent Crohn’s after surgery, Gutsy Group
$80,000 ($40,000 in 2012)
Prof Michael Kamm
IBD in Asia, Broad Foundation
$220,000 for 2 years ($110,000 in 2012)
Collaborations in research
International
• Duke Research Centre,
• St Mary’s Hospital Hong Kong,
• Multiple international clinical trials
National
• The Australian Liver Association
• IBD Australia
Victorian
• Victorian Infectious Diseases
ReferenceВ Laboratory,
• The Melbourne Liver Group,
• The Australian Liver Association,
• The Murdoch Research Institute,
• CSIRO, Melbourne University,
• Monash University
Publications
Journal articles
Arroyo Martinez Q, DeCruz P, Murugananthan A,
Desmond P, Chen R. Endoscopic ultrasound-guided
fine needle aspirate: a useful method in theВ diagnosis
of pancreatic tuberculosis. ANAВ JВ Surg. 2012
Apri;82(4):282–3.
De Cruz P, Kamm MA, Prideaux L, AllenВ PB,
Desmond PV. Postoperative recurrent luminal Crohn’s
disease: a systematic review. Inflamm BowelВ Dis.
2012 Apr;18(4):758–77.
Efthymiou M, Desmond PV, Brown G, La Nauze
R, Kaffes A, Chua TJ, Taylor AC. SINGLE–01: a
randomized, controlled trial comparing the efficacy
and depth of insertion of single – and double –
balloon enteroscopy by using a novel method to
determine insertion depth. Gastrointest Endosc. 2012
Nov;76(5):972–80.2012.
Holmes JA, Desmond PV, Thompson AJ. Does IL28B
genotyping still have a role in the era of direct-acting
antiviral therapy for chronic hepatitis CВ infection? J
Viral Hepat. 2012 Oct;19(10):677–84.
Jayasekera CS, Taylor AC, Desmond PV, MacraeВ F,
Williams R. Added value of narrow band imaging and
confocal laser endomicroscopy in detecting Barrett’s
oesophagus neoplasia. Endoscopy, 2012 Dec, 44(12)
1089–95.
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GASTROENTEROLOGY
Benjamin JL, Hedin CR, Koutsoumpas A, NgВ SC,
McCarthy NE, Prescott NJ, Pessoa-Lopes P, Mathew
CG, Sanderson J, Hart AL, KammВ MA, Knight SC,
Forbes A, Stagg AJ, Lindsay JO, WhelanВ K. Smokers
with active Crohn’s disease have a clinically relevant
dysbiosis of the gastrointestinal microbiota. Inflamm
Bowel Dis. 2012 Jun;18(6):1092–100.
Prideaux L, Kamm MA, De Cruz P, Williams J, BellВ SJ,
Connell WR, Brown SJ, Lust M, DesmondВ PV, Chan
H, Chow DK, Wu JC, LeongВ RW, Sung JJ, Chan
FK, Ng SC. ComparisonВ of Clinical Characteristics
and Management of Inflammatory Bowel Disease
inВ HongВ Kong versus Melbourne. J Gastroenterol
Hepatol. 2012 May;27(5):919–27.
Emmanuel AV, Kamm MA, Roy AJ, Kerstens R,
Vandeplassche L. Randomised clinical trial: the
efficacy of prucalopride in patients with chronic
intestinal pseudo-obstruction – a double-blind,
placebo-controlled, cross-over, multiple n = 1 study.
Aliment Pharmacol Ther. 2012 Jan;35(1):48–55.
Tozer P, Ng SC, Siddiqui MR, Plamondon S,
BurlingВ D, Gupta A, Swatton A, Tripoli S, Vaizey CJ,
Kamm MA, Phillips R, Hart A. Long-term MRI-guided
combined anti-TNF-О± and thiopurine therapy for
Crohn’s perianal fistulas. Inflamm Bowel Dis. 2012
Oct;18(10):1825–34.
Peyrin-Biroulet L, Cieza A, Sandborn WJ, CoenenВ M,
Chowers Y, Hibi T, Kostanjsek N, StuckiВ G, Colombel
JF; International Programme toВ Develop New Indexes
for Crohn’s Disease (IPNIC) group: Reinisch W, Tilg H,
Kamm M, D’Haens G, Louis E, Van Assche G,
Feagan B, Irvine EJ, Michetti P, Hibi T, Schölmerich J,
Schreiber S, MunkholmВ P, PanesВ J, Colombel JF,
Cosnes J, LГ©mann M, LewinВ M, Mary JY, Pariente
B, Peyrin-Biroulet L, Travis S, Chowers Y, Danese
S, Vecchi M, HommesВ DW, Oresland T, Fletcher J,
Loftus EV Jr, SandbornВ WJ, Sands BE. Development
of the first disability index for inflammatory bowel
disease based on the international classification
of functioning, disability and health. Gut. 2012
Feb;61(2):241–7.
De Cruz P, Bernardi MP, Kamm MA, Allen P, Prideaux
L, Williams J, Johnston M, Keck J, Brouwer R, Heriot
A, Woods R, Brown S, Bell S, Elliott R, Connell W,
Desmond PV.Post-Operative Recurrence of Crohn’s
Disease: Impact of Endoscopic Monitoring and
Treatment Step-Up. Colorectal Dis. 2012 Jul 3. doi:
10.1111/j.1463–1318.2012.03168.x. [Epub ahead
ofВ print]
Ng SC, Tsoi KK, Kamm MA, Xia B, Wu J, Chan FK,
Sung JJ. Genetics of inflammatory bowel disease
inВ Asia: Systematic review and meta-analysis. Inflamm
Bowel Dis. 2012 Jun;18(6):1164–76.
De Cruz P, Kamm MA, Prideaux L, Allen PB,
Desmond PV. Postoperative recurrent luminal Crohn’s
Disease: A systematic review. InflammВ Bowel Dis.
2012 Apr;18(4):758–77.
Prideaux L, De Cruz P, Ng SC, Kamm MA.
Serological antibodies in inflammatory bowel disease:
A systematic review. Inflamm Bowel Dis. 2012
Jul;18(7):1340–55.
De Cruz P, Kamm MA, Prideaux L, Allen PB,
Moore G. Mucosal healing in Crohn’s disease:
AВ systematic review. Inflamm Bowel Dis. 2012 Apr 26.
doi: 10.1002/ibd.22977. [Epub ahead of print].
Prideaux L, Kamm MA, De Cruz PP, Chan FK,
Ng SC. Inflammatory bowel disease in Asia:
AВ systematic review. J Gastroenterol Hepatol.
2012 Aug;27(8):1266–80.
Al-Hassi HO, Bernardo D, Murugananthan AU, Mann
ER, English NR, Jones A, Kamm MA, ArebiВ N, Hart AL,
Blakemore AI, Stagg AJ, Knight SC. AВ mechanistic
role for leptin in human dendritic cell migration:
differences between ileum and colon inВ health and
Crohn’s disease. Mucosal Immunol. 2012 Nov 21.
doi: 10.1038/mi.2012.113. [Epub ahead of print]
De Cruz P, Prideaux L, Wagner J, Ng SC,
McSweeney C, Kirkwood C, Morrison M, Kamm MA.
Characterization of the gastrointestinal microbiota
in health and inflammatory bowel disease. Inflamm
Bowel Dis. 2012 Feb;18(2):372–90.
Efthymiou M, Allen PB, Jayasekera C, Taylor PV,
Taylor AC. Value of fecal occult blood test as a
screening test before capsule endoscopy. Eur J
Gastroenterol Hepatol. 2011 Aug;23(8):690–4.
Veldt BJ, Duarte-Rojo A, Thompson AJ, et al.
Recipient IL28B polymorphism is an important
independent predictor of posttransplant diabetes
mellitus in liver transplant patients with chronic
hepatitis C. Am J Transplant 2012;12:737–44.
Thompson AJ, Patel K, Chuang WL, et al. Viral
clearance is associated with improved insulin
resistance in genotype 1 chronic hepatitis C
but not genotype 2/3. Gut 2012;61:128–34.
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GASTROENTEROLOGY
Thompson AJ, Clark PJ, Singh A, et al. Genome-wide
association study of interferon-related cytopenia in
chronic hepatitis C patients. J Hepatol 2012;56:313–9.
Naggie S, Rallon NI, Benito JM, et al. Variants in the
ITPA gene protect against ribavirin-induced hemolytic
anemia in HIV/HCV-coinfected patients with all HCV
genotypes. J Infect Dis 2012;205:376–83.
Naggie S, Osinusi A, Katsounas A, et al. Dysregulation
of innate immunity in hepatitis C virus genotype
1 IL28B-unfavorable genotype patients: impaired
viral kinetics and therapeutic response. Hepatology
2012;56:444–54.
Cheng Y, Guindon S, Rodrigo A, et al. Cumulative
viral evolutionary changes in chronic hepatitis
B virus infection precedes hepatitis B e antigen
seroconversion. Gut 2012. Dec 15. [Epub ahead
ofВ print]
Cabuang LM, Shaw T, Littlejohn M, et al. In vitro
replication phenotype of a novel (–1G) hepatitis B virus
variant associated with HIV co-infection. J Med Virol
2012;84:1166–76.
Speaking engagements
Dr Alex Thompson
Naggie S, Osinusi A, Katsounas A, et al. Dysregulation
of innate immunity in hepatitis C virus genotype 1
IL28B-unfavorable genotype patients: Impaired viral
kinetics and therapeutic response. Hepatology 2012.
• Asia-Pacific Digestive Diseases Week (APDW),
December 2012, Bangkok, Thailand. Plenary
Lecture: �Current and future perspective of
hostВ genomes and chemokines in management
ofВ chronic hepatitis B.
Lucas JE, Thompson JW, Dubois LG, et al.
Metaprotein expression modeling for label-free
quantitative proteomics. BMC Bioinformatics
2012;13:74.
• APDW Postgraduate Course, December 2012,
Bangkok, Thailand: �Management of chronic
hepatitis B infection’.
Jazwinski AB, Thompson AJ, Clark PJ, Naggie S,
Tillmann HL, Patel K. Elevated serum CK18 levels
in chronic hepatitis C patients are associated with
advanced fibrosis but not steatosis. J Viral Hepat
2012;19:278–82.
Howell CD, Gorden A, Ryan KA, et al. Single
nucleotide polymorphism upstream of interleukin
28BВ associated with phase 1 and phase 2 of early
viral kinetics in patients infected with HCV genotype
1. J Hepatol 2012;56:557–63.
Clark PJ, Thompson AJ, Zhu Q, et al. The association
of genetic variants with hepatic steatosis in patients
with genotype 1 chronic hepatitis C infection. Dig Dis
Sci 2012;57:2213–21.
Clark PJ, Thompson AJ, Zhu M, et al. Interleukin
28B polymorphisms are the only common genetic
variants associated with low-density lipoprotein
cholesterol (LDL-C) in genotype-1 chronic hepatitis C
and determine the association between LDL-C and
treatment response. J Viral Hepat 2012;19:332–40.
• American Association for the Study of the Liver
(AASLD) Postgraduate Course, November 2012,
Boston, USA. Lecture: �Human and viral genomes:
predictors of response’.
• European Association for the Study of the Liver
(EASL) Single Topic Conference on Therapy
of Hepatitis C: Clinical Applications and Drug
Development, September 2012, Prague, Czech
Republic. Lecture: �Will HCV still be a medical
problem in 2025?’
• Triennial International Symposium on Viral
Hepatitis and Liver Diseases, Shanghai, China,
June, 2012. Lecture: �Genomic-based treatment
paradigms for patients with chronic hepatitis C.
• AASLD single topic conference, March
2012, Atlanta, USA. Lecture: �HCV Direct
Antiviral Agents: Concepts, Development,
and Optimal Use’
• AGW, October 2012, Adelaide. Lecture: �Host
genetic testing in the era of direct-acting antiviral
agents for HCV’
Clark PJ, Thompson AJ, Vock DM, et al. Hepatitis
C virus selectively perturbs the distal cholesterol
synthesis pathway in a genotype-specific manner.
Hepatology 2012;56:49–56.
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Haematology
The Haematology Department participates
in a wide breadth of research activities that
encompass basic science research in leukaemia
and thrombosis and extend into clinical trials
using cutting-edge chemotherapy drugs.
About us
The research activities undertaken within the
Haematology Department include the study of
the biochemical processes that cause leukaemia
and blood clotting disorders and participation
in clinical research to test the usefulness of new
emerging treatments in the cure of several types
of blood cancers.
Major projects
Basic Science Research Projects:
• Identification of mechanisms causing miscarriages
in antiphospholipid syndrome: In this project
weВ have studied the capacity of certain proteins
present on blood vessel surface to prevent the
development of miscarriages in autoimmune
diseases. (Funding from NHMRC)
• Characterisation of a new protein with
antithrombotic activity: We have discovered a
newВ function for an existing blood vessel protein
in the causation of blood clots. (Funding from
theВ Heart Foundation)
• Discovering genes that cause leukaemia:
ByВ theВ study of patient samples, we have
discovered genes that have the potential
toВ causeВ leukaemia and we are confirming
theirВ cancer-causing potential. (Funding
fromВ theВ Leukaemia Foundation)
Clinical and Translational Research:
HREC-D 165/10 An adaptive, comparative,
randimised, parallel-group, multi centre, Phase
1BВ study of (S/C) rituximab vs (IV) rituximab
bothВ inВ combination with Bendamustine
inВ ptsВ withВ previously untreated CLL
HREC-D 158/12 A Randomized, Multicenter,
Open-label, Phase 3 Study of the Bruton’s
TyrosineВ Kinase (BTK) Inhibitor Ibrutinib versus
Ofatumumab in Patients with Relapsed or
RefractoryВ Chronic Lymphocytic Leukemia/
SmallВ Lymphocytic Lymphoma
HREC 158/08 A Ph. 3, multicenter, randomised,
double blind, placebo-controlled, parallel-group
study of the efficacy and safety of Lenalidmide
(Revlimid) as maintenance therapy for patients
withВ B-cell lymphocytic leukemia following
secondВ line therapy
HREC -D 116/11 A Multi-centre, Phase 111 OpenLabel, Randomized Study in Previously Untreated
Patients with Advanced Indolent Non-Hodgkin’s
Lymphoma Evaluating the Benefit of GA101 plus
Chemotherapy Compared with Rituximab plus
Chemotherapy followed by GA101 or Rituximab
Maintenance therapy in Responders
HREC-D 166/10 A Double Blind Multicentre
Randomised Phase 111 study in Patients with
Diffuse Large B-cell Lypmphoma Evaluating the
benefit of Maintenance Therapy with Lenalidomide
after Induction of Response with R-CHOP
chemotherapy in Comparison with Placebo
Maintenance Therapy (ALLG NHL25-REMARC)
HREC – 108/09 A phase 3, multi-centre,
randomised, open-label, parallel-group study
ofВ theВ efficacy and safety of lenalidomide
(revlimid)В versus chlorambucil as first-line
therapyВ forВ previously untreated elderly patients
withВ B-cell chronic lymphocytic leukaemia
HREC-D 037/09 A two stage Phaase 1b study
to Investigate the pharmacokinetics, safety
and tolerability of rituximab subcutaneous (SC)
formulation in patients with follicular lymphoma
asВ part of maintenance treatment
HREC-D 083/10 A phase 11, Multi-centre,
Randomised, Controlled, Open-Label Study
ofВ theВ Safety, Efficacy and Pharmacokinetics
of ABT-263 in Combination with Dose-Intensive
Rituximab of Dose-Intensive Rituximab Alone
inВ Previously Untreated Patients with B-cell,
ChronicВ Lymphocytic Leukaemia (CLL)
HREC-D 121/09 An open label, randomised,
parallel-group study of bendamustine hydrochloride
and rituximab (BR) compared with rituximab,
cyclophosphamide, vincristine, and prednisone
(R-CVP) or rituximab, cyclophosphamide,
doxorubicin, vincristine and prednisone(R-CHOP)
in the first line treatment of patients with advanced
indolent Nn-Hodgkin’s Lymphoma (NHL) or Mantle
Cell Lymphoma (MCL)
st vincent’s research report 2012
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Haematology
HREC-D 105/02 (CML6) A Phase 11 Study in adult
patients with newly-diagnosed myeloid leukaemia
of initial intensified Glivec therapy, and sequential
combination therapy for non-responders
Dr James Griffiths, Honorary Consultant
Haematologist, 0.0EFT
PCYC-1112-CA: A Randomized, Multicenter, Openlabel, Phase 3 Study of the Bruton’s Tyrosine Kinase
(BTK) Inhibitor Ibrutinib vs Ofatumumab in Patients
with Relapsed or Refractory Chronic Lymphocytic
Leukemia / Small Lymphocytic Lymphoma
Dr Kritika Chaiwatanatorn, Consultant
Haematologist, Quality Improvement, 0.3EFT
PCYC-1117-CA: An Open-Label, Single Arm,
Multicenter Phase 2 Study of the Bruton’s Tyrosine
Kinase Inhibitor PCI-32765 (Ibrutinib) in Patients
with Relapsed or Refractory Chronic Lymphocytic
Leukemia or Small Lymphocytic Lymphoma with
17p Deletion
Dr Anne Dykes, Consultant Haematologist,
QualityВ Improvement, 0.4EFT
Dr Sue Morgan, Consultant Haematologist,
QualityВ Improvement, 0.1EFT
Dr Newton Lee, Consultant Haematologist,
ClinicalВ Research, 0.2EFT
Prof Harshal Nandurkar, Consultant Haematologist,
Basic Research, 0.2EFT
Ms Helen Worland, Trial Coordinator, 0.8EFT
Ms Ady Bridget, Trial Coordinator, 1.0EFT
TTP Registry [for St Vinent’s]
Ms Carly Selan, Research Assistant,
(untilВ AprilВ 2011-then maternity leave) 1.0EFT
�Transfusion research; Improving Outcomes;
NHMRC Partnership Grant [PI Prof. J. Mc Neil],
tillВ end 2012 [no. 546291].
Students
Mr Anup Sharma, PhD Student
Patient Blood management in Critical Illness
andВ Trauma. NH & MRC funding from mid 2012
forВ 5 years [PI Prof. J. Cooper], Monash University
[no. 1040971]
Ms Anushka Samudra, PhD Student
Quality
Service to the wider community
• Audit of inferior Vena Cava Filter insertion
and clinical follow up at St Vincent’s Hospital
(2В year follow up data)
Dr Robin Filshie:
• Venous thromboembolism prevention in cancer
patients undergoing colorectal surgery. Submitted
for publication to ANZ Journal of Surgery
Dr Matthew Ku, PhD Student
Dr Sarah Kamel, PhD student
• Member of the Safety and Data Monitoring
Committee of the Australian Leukaemia
andВ Lymphoma Group
• Chair of Human Ethics Research Committee
(D) of St Vincent’s Health.
Staff
Dr Merrole Cole-Sinclair:
Dr Robin Filshie, Consultant Haematologist,
ClinicalВ Research, 1.0EFT
• Chief Examiner, Haematology, RCPA
(untilВ December 2012
Dr Hang Quach, Consultant Haematologist,
ClinicalВ Research, 1.0EFT
• Chair, STV Transfusion Committee
Dr Merrole Cole-Sinclair, Consultant Haematologist,
Clinical Research and Quality Improvement, 1.0EFT
Dr Ali Bazargan, Consultant Haematologist,
ClinicalВ Research, 0.2 EFT
A/Prof Frank Firkin, Honorary Consultant
Haematologist, 0.0EFT
Dr Con Tam Honorary Consultant Haematologist,
0.0EFT
• Chair, Haematology Advisory Committee,
RCPAВ [from December 2012]
• Chair, Transfusion Outcomes Research
Collaborative [�TORC’, ARCBS and
MonashВ University]
• Chair, Joint Specialist Advisory Committee
inВ Haematology, RCPA and RACP (Co-chair
until Dec’12)
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Haematology
• Chair, Transfusion Research; Improving outcomes
�TRIO’, NH & MRC
Dr Ali Bazargan:
• Chair, Partnership Grant Steering Committee
[tillВ end 2012]
• Member, VTE committee
• Member, Mortality review committee
• Member, STV Pathology Clinical Quality Council
• Member, Transfusion committee
St Vincent’s Private Hospital
• Member, SVP Transfusion Committee
• Member, Cancer executive council
• Member, Serious Transfusion Incident Review
[STIR] Committee, Department of Health, Victoria
Prof Harshal Nandurkar:
• Member, TORC Aplastic Anaemia Registry
Steering Committee
• Member, TORC Haemoglobinopathy Registry
Steering Committee
• Chair, VTE Committee
• Chair, Quality Improvement
PresentationsВ Committee
• Chair, Research week Committee
• Member, Victorian Blood User Group
• Member, Board of St Vincent’s Foundation
• Member, Judging Panel, Stawell Prize, AMA
• Member, Cancer Executive
• Member, Board of Censors, RCPA
(untilВ DecemberВ 2012)
• Member, University of Melbourne
postgraduateВ Committee
• Member, Point of Care Testing Task Force, RCPA
• Member, Senior Medical Staff Executive Council
• Member, Joint Specialist Advisory Committee
inВ Haematology, RCPA & RACP
• Member, Pathology Executive
• Member, Haematology Advanced Training
Centralised Appointments-Victorian Committee
Dr Constantine Tam:
• Chair, Australian Febrile Neutropenia
WorkingВ Group
• Councillor, Specialist Review Council, Department
of Veterans’ Affairs (2009 – 2012).
• Session Chairman, Haematology-Oncology
Targeted Therapy Meeting (2009 – 2012).
• Scientific Advisory Committee, Australasian
Leukaemia & Lymphoma Group (2010 – 2013).
• Chair of Supportive Care, Australasian Leukaemia
& Lymphoma Group (2010 – 2013).
• Chair of CML / Chronic Myeloproliferative
Diseases, Australasian Leukaemia & Lymphoma
Group (2011 – 2013).
• St Vincent’s Hospital Medical Cancer Executive
Board (2009 – 2012); Executive Clinical
Improvement Committee (2009 – 2012);
Hospital Mortality Committee (2009 – 2011).
• Advisory Board Member: Roche Australia,
RocheВ Global, GlaxoSmithKline Australia,
NovartisВ Australia, Bristol-Myers Squibb
Australia (2009 – 2012).
• Secretary, Australian Society of Haemostasis
andВ Thrombosis
Grants
Harshal Nandurkar and Peter Cowan
Role of GRP78 as a novel antithrombotic,
HeartВ Foundation
$130,000 for 2011–2013 ($65,000 in 2012)
Con Tam
Using Next Generation Sequencing to Identify
Patients with CLL Who Do Not Response to
Chemotherapy, Equity Trustees
$32,984 for 2012
Con Tam
CLL Biomarkers and Chemotherapy Resistance,
CASS Foundation
$50,000 for 2012
Collaborations in research
International
• University of British Columbia, Vancouver, Canada
• Beth Israel Deaconess Medical Centre, Boston,
USA
• MD Anderson Cancer Centre, Houston, USA
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National
• Australian Centre for Blood Diseases,
AlfredВ Hospital and Monash University
• Department of Biochemistry, Monash University
• Department of Biochemistry, Bio21,
UniversityВ ofВ Melbourne
• St Vincent’s Insitute, Fitzroy
• CSIRO-Molecular Health Technologies, Parkville
Publications
Book chapters
Tam CS & Mulligan SP: Chronic Lymphocytic
Leukaemia – Diagnosis and Clinical Staging.
Advances in the Treatment of B-Cell Chronic
Lymphocytic Leukemia, Future Science Group
(UK)В E-Book, 2012.
Tam CS & Verstovsek S: Management of
Polycythemia Vera. Expert Clinical Perspective
onВ Diagnosis & Management of Cancer: Analysis
ofВ Controversies and Uncertainties in Cancer,
WileyВ Press.
Journal articles
George A, Tam CS, Seymour JF. High Risk Diffuse
Large B-Cell Lymphoma – Can We Do Better than
R-CHOP? Leukemia & Lymphoma 2013, in press.
Experts in CML. Price of Drugs for Chronic Myeloid
Leukemia (CML): Reflection of the Unsustainable
Cancer Drug Prices – Perspective of CML Experts.
Blood 2013, in press.
Thompson PA, Tam CS. CD38 Expression in CLL
– A Dynamic Marker of Prognosis. Leukemia &
Lymphoma 2013, in press.
Verstovsek S, Tam CS, Shah N. Phase I Evaluation
of XL019, An Oral, Potent and Specific JAK2
Inhibitor. Manuscript in preparation.
Shafik-Eid Ray, Tam CS, Hennessy OF, McKelvie
PA, Galloway SJ, Lee WK. Amyloid-Like Nodal Light
Chain Deposition Disease Complicating Chronic
Lymphocytic Leukemia. Manuscript in preparation.
Santos FPS, Tam CS, Kantarjian H, Cortes J,
Thomas D, Pollock R, Verstovsek S. Splenectomy
in Patients with Myeloproliferative Neoplasms:
Efficacy, Complications and Impact on SurvivalВ and
Transformation. Leukemia & Lymphoma 2013, inВ press.
Best OG and Tam CS. Protein Kinase C Isoform
Expression in Chronic Lymphocytic Leukemia:
Potential Target for Therapy? Leukemia & Lymphoma
2013, in press.
Gregory G, Arumugaswamy A, Leung T, ChanВ KL,
Abikhair M, Tam CS, Bajel A, Cher L, Grigg A,
Ritchie D, Opat S. Rituximab is Associated with
Improved Survival for Aggressive B-Cell Central
Nervous System Lymphoma. Neuro-Oncology 2013,
in press.
Tam CS, Verstovsek S. Investigational Janus Kinase
Inhibitors. Expert Opinion on Investigational Drugs
2013, prepublished Feb 23, 2013.
Tam CS & Keating MJ. Selection of Rituximab
Dosage in Chronic Lymphocytic Leukemia :
Where is the Evidence?. Leukemia & Lymphoma,
prepublished Sep 28, 2012.
Chan KL, McKelvie P, Firkin F, Bazargan A,
TamВ CS.В Chronic Lymphocytic Leukemia
PresentingВ asВ an Intracranial Epidural Mass
in aВ Patient with Myeloproliferative Neoplasm
Associated with JAK2 V617F Mutation. Leukemia
&В Lymphoma, prepublished Nov 19, 2012.
Tan XL, Tam CS, McKellar R, Nandurkar N,
Bazargan A. Out of Sight, Out of Mind: An Audit
ofВ Inferior Vena Cava Filter Insertion and Clinical
Follow-up in an Australian Institution and Literature
Review. Internal Medicine Journal, prepublished
JulyВ 4, 2012.
Tam CS. Allogeneic Immunity and Anti-CD20
Therapy: A Potent Combination in the Treatment
of a Patient with Richter Transformation of CLL.
Leukemia & Lymphoma 2013; 54:7-8.
Best G, Thompson P, Tam CS. Diagnostic
Techniques and Therapeutic Challenges in Patients
with TP53 Dysfunctional Chronic Lymphocytic
Leukemia. Leukemia & Lymphoma 2012; 53:2105–15.
McKelvie P, Oon S, Romas E, Nandurkar H,
TamВ CS. A Case of ALK-Negative Anaplastic Large
CellВ Lymphoma Associated with Hypereosinophilia,
Granulomatous Myositis and Vasculitis. Leukemia
& Lymphoma 2012; 53:2279–82.
McKelvie P, Thompson P, Tam CS. Peripheral T-cell
and NK/T-cell Lymphomas: A Clinicopathological
Study from One Australian Center. Histopathology
2012; 61: 212–23.
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Haematology
Bazargan A, Tam CS, Keating MJ. Predicting
Survival in Chronic Lymphocytic Leukemia. Expert
Review of Anticancer Therapy 2012; 12:393–403.
Tam CS and Gandhi V. Modifying the Immune
System to Treat Chronic Lymphocytic Leukemia.
Leukemia & Lymphoma 2012; 53:177–178.
Perioperative Management of Anticoagulation in
Elective Surgery ANZ Journal of Surgery (In press)
Ruth N MacKinnon, Carly Selan, Adrian Zordan,
Meaghan Wall, Harshal Nandurkar, Lynda J
Campbell. CGH and SNP array using DNA extracted
from fixed cytogenetic preparations and long-term
refrigerated bone marrow specimens. Molecular
Cytogenetics 2012, 5:10
Xu Y, Huntington ND, Harder KW, Nandurkar H,
Hibbs ML, Tarlinton DM. Phosphatidylinositol-3
kinase activity in B cells is negatively regulated
by Lyn tyrosine kinase. Immunol Cell Biol. 2012
Oct;90(9):903–11.
Meretoja Atte, Churilov Leonid, Campbell, Bruce,
Aviv Richard, Yassi Nawaf, Barras Christen,
Mitchell Peter, Yan Bernard, Nandurkar Harshal,
BladinВ Christopher, Wijeratne Tissa, Spratt Neil,
Jannes Jim, Sturm Jon, RupasingheВ Jayantha,
Zavala Jorge, Lee Andrew, Kleinig Tim,
MarkusВ Romesh, Delcourt Candice, Mahant Neil,
Parsons Mark, Levi Christopher, Anderson CraigВ S,
Donnan Geoffrey, Davis Stephen. The Spot sign
and Tranexamic acid On Preventing ICH growth
– AUStralasia Trial (STOP-AUST). Protocol of a
phase II randomized placebo-controlled doubleblind multicentre trial. International Journal of Stroke
(accepted April 2013).
Enticott J C, Jeffcott S, Ibrahim J E, Wood E
M, Cole-Sinclair M, Fitzgerald M, Cameron P
A, Phillips L E. “A review on decision support;
understanding human factors to support the
implementation of complex interventions in trauma”.
Transfusion 2012 52 (12) 2692–705.
Iland HJ, Bradstock K, Supple SG, Catalano A,
Collins M, Hertzberg M, Browett P, Grigg A, FirkinВ F,
Hugman A, Reynolds J, Di Iulio J, Tiley C, TaylorВ K,
Filshie R, Seldon M, Taper J, Szer J, Moore J,
Bashford J, Seymour JF; Australasian Leukaemia
and Lymphoma Group. All-trans-retinoic acid,
idarubicin, and IV arsenic trioxide as initial therapy
inВ acute promyelocytic leukemia (APML4). Blood.
2012 Aug 23;120(8):1570–80;
Brighton TA, Eikelboom JW, Mann K, Mister R,
Gallus A, Ockelford P, Gibbs H, Hague W, XavierВ D,
Diaz R, Kirby A, Simes J; ASPIRE Investigators.
Low-dose aspirin for preventing recurrent venous
thromboembolism. N Engl J Med. 2012 Nov
22;367(21):1979–87
Dewamitta SR, Russell MR, Nandurkar H,
Walkley CR. Darbepoietin-О± has comparable
erythropoietic stimulatory effects to recombinant
erythropoietin whilst preserving the bone marrow
microenvironment. Haematologica. 2012 Dec 14.
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Haematology
Speaking engagements
Gregory G, Arumugaswamy A, Leung T, Chan KL,
Abikhair M, Kipp D, Tam CS, Bajel A, Cher L, Gan H,
Grigg A, Ritchie D, Opat S. Immuno-Chemotherapy
Containing Rituximab Is Associated With Improved
Survival in Primary CNS Lymphoma. European
Hematology Association Meeting, 2012.
Santos FP, Tam CS, Kantarjian HM, Cortes J,
Thomas DA, Pollock R, Verstovsek S. Splenectomy
in Patients with Myeloproliferative Neoplasms:
Efficacy, Complications and Impact on Survival
andВ Transformation. American Society of
Hematology Meeting, 2012.
Keating MJ, Tam CS, Wierda WG, O’Brien S,
Thomas DA, Cortes JE, Lerner S, Plunkett W.
IsВ Chronic Lymphocytic Leukemia Still Incurable?
American Society of Hematology Meeting, 2012.
Burger J, Ghia P, Polliack A, Tam CS, Suri D, ClowВ F,
Kraljevic S, James D, Kipps TJ. Randomized,
multicenter, open-label, phase III study of the
BTKВ inhibitor ibrutinib versus chlorambucil in
patientsВ 65 years or older with treatment-naive
CLL/SLL (RESONATE-2). American Society
ofВ Clinical Oncolgy Meeting 2013.
Nandurkar, H: Role of fibrinogen in cardiovascular
disease. Invited Presentation, Asia-Pacific Society
ofВ Thrombosis and Haemostasis 2012
Nandurkar, H: Role of Complement inhibitor therapy
in PNH. Invited presentation, Federation of ASEAN
Societies of Haematology Meeting, 2012
Nandurkar, H: Role of Complement inhibitor therapy
in PNH. Invited presentation, Philippines Society
ofВ Haematology of Haematology Meeting, 2012
Nandurkar H: Neurological manifestations of
APS. Invited Presentation. Australian Society of
thrombosis and Haemostasis Annual Meeting 2012
Nandurkar H, Samudra Anushka et al: Purinergic
signalling in APS miscarriages. Asia-Pacific Society
of Thrombosis and Haemostasis 2012
Nandurkar H, Sharma Anup et al: GRP78 is
aВ novelВ regulator of Haemostasis. Asia-Pacific
SocietyВ of Thrombosis and Haemostasis 2012
st vincent’s research report 2012
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Immunology
The Immunology Research Centre is focused on
the study of transplant immunobiology, covering
a range of areas including xenotransplantation,
allotransplantation, ischemia reperfusion injury,
transplant tolerance, innate immunity, islet graft
revascularisation, regulatory T cells, and the links
between thrombosis and inflammation.
Major projects
The Immunology Research Centre studies
immunological mechanisms that cause transplanted
organs and tissues to fail and aims to improve
the lives of those patients who die on waiting lists
due a lack of organs for transplantation or suffer
from complications after transplantation caused
byВ aspects of the immune and clotting systems.
In 2012 we were honoured to have Prof Peter
Cowan appointed as the Scientific Program
Chair for the Joint Congress of the International
Xenotransplantation Association; The International
Pancreas and Islet Transplant Association; and
theВ Cell Transplant Society, to be held in Melbourne
inВ November 2015.
Significant research projects in 2012 include:
Transplant tolerance
kidney 4 weeks post Ischaemia when the untreated
kidney remains in place compared to those mice
where the untreated kidney was removed.
Protecting islets in a diabetic model
The success of islet transplantation in type 1
diabetes is determined by islet survival. Work
onВ whether a nucleotide metabolizing enzyme
(CD39) that promotes the generation of adenosine,
could mitigate diabetes in a mouse model
demonstrated that mice containing the CD39
geneВ were protected from induced diabetes
pointingВ toВ aВ potential strategy to protect islet
grafts from T cell–mediated injury.
Better understanding pre-eclampsia
CD39, a nucleotide metabolizing enzyme which
coverts ADP to AMP, is an integral component
of regulatory T cells (Treg), which are central
toВ immunological tolerance and maintenance
ofВ normal pregnancy. Using antibodies to induce
pre-eclampsia allowed us to show that animals
overexpressing the CD39 enzyme were protected
when compared to normal mice, leading to a better
understanding of this disease process.
Identification of patients at high risk of renal
transplant rejection
The ABO blood group system is critical in
transplantation, however, unlike adults infants
doВ not reject ABO-incompatible heart transplants,
they develop �tolerance’. It is very difficult to study
the mechanisms of tolerance in such a limited
population, yet mice do not have ABO blood
groups. Our alternative: generate transgenic
mice which express the human blood group �A’
on their tissues. When hearts from blood group
�A’ mice were transplanted into normal mice they
were rejected,В providing us with a unique model
to investigate transplant tolerance and antibodymediated rejection.
Regulatory T cells (Treg) and T effector cells (Teff)
are important in mediating immune tolerance and
outcomes of allotransplantation. Ongoing studies
using a range of markers (CD4, CD25 and CD39)
to track Treg and T eff cell populations in renal
transplant patients have shown those patients
whoВ have lower numbers of these cell types are
more likely to suffer cell mediated rejection. It
is hoped that tracking these changes may help
identifyВ and better treat patients with higher risk
ofВ renal allograft rejection.
Models of ischaemic
ChronicВ KidneyDiseaseВ (CKD)
Prof Peter Cowan, Scientist Director 1.0 EFT
The development of two complementary models
ofВ CKD based on disruption of blood flow (Ischaemia
Reperfusion Injury) provided both the tools to better
understand the injury caused by CKD as well as
posing the conundrum of why two kidneys are not
always better than one. Results from this work have
clearly shown increased fibrosis in a treated mouse
Staff
Dr Karen Dwyer, Senior Medical Staff
andВ Co-Director 0.5 EFT
Prof Harshal Nandurkar, Senior Medical Staff
0.5 EFT
Neil Wilson, Laboratory Manager 1.0 EFT
Dr Jennifer McRae, Senior Research Officer 0.8 EFT
Dr Bo Lu, Senior Research Officer 0.8 EFT
st vincent’s research report 2012
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Immunology
Evelyn Salvaris, Senior Research Assistant 1.0 EFT
Prof Harshal Nandurkar
Carly Selan, Senior Research Assistant 1.0 EFT
• Chair, VTE Committee
Nella Fisicaro, Senior Research Assistant 0.8 EFT
• Chair, Quality Improvement
PresentationsВ Committee
Jo Chia Research Assistant 0.4 EFT
Julie Brown, Medical Laboratory Assistant 0.6 EFT
• Chair, Research week Committee
• Member, Board of St Vincent’s Foundation
Students
• Member, Cancer Executive
Joanne Chia, PhD Student
Eddy Lee, PhD Student
• Member, University of Melbourne
postgraduateВ Committee
Siddharth Rajakumar, PhD Student
• Member, Senior Medical Staff Executive Council
Veena Roberts, PhD Student
• Member, Pathology Executive
Anushka Samudra, PhD Student
• Secretary, Australian Society of Haemostasis
andВ Thrombosis
Anup Sharma, PhD Student
Matthew Ku, PhD student
Theses passed in 2012
Kwong Fei Eddy Lee. Overexpression ofВ Human
Endothelial Protein C Receptor to Regulate
Thrombosis and Inflammation in Solid Organ
andВ Cellular Xenotransplantation. PhD,
UniversityВ ofВ Melbourne.
Service to the wider community
Cowan PJ
• Associate Editor, Xenotransplantation.
• Secretary/Treasurer, International
Xenotransplantation Association.
• Chairman, Institutional Biosafety Committee,
St Vincent’s Hospital Melbourne.
• Principal Research Associate, St Vincent’s Institute
Dwyer, KM
• Professional Development Advisor
andВ Educational Advisor, Royal Australian
CollegeВ ofВ Physicians
• Senior Medical staff Rep on AEC
• Journal reviewer: Journal of Clinical Investigation;
Journal of American Society of Nephrology;
Journal of Immunology; Nephrology; Internal
Medicine; Xenotransplantation; American Journal
of Transplantation; Immunology and cell biology
• Melbourne Teaching Certificate: Medical
school education – undergraduate and
postВ graduate teaching
Grants
d’Apice AJF, Cowan PJ, Lew AM, O’Connell
PJ, Robson SC, Nottle MB, Dwyer KM,
SutherlandВ RM, Allen RDM, Hawthorne WJ,
Enjyoji K, Simidjiyska AU, Beebe L, Harrison S.
Which transgenic pig will be used for islet
transplantation in humans, NHMRC/JDRF
$3,000,000 for 2008–2013 ($573,864 in 2012)
Cowan PJ, d’Apice AJF, Nottle MB.
Preclinical studies in xenotransplantation, NHMRC
$1,172,600 for 2009–2012 ($211,235 in 2012)
Dwyer KM
The expression of CD39 on islet cells prolongs graft
survival following transplantation, CASS Foundation
$50,000 for 2012
De Kretser D, O’Hehir R, Dwyer KM
The use of follistatin to treat the reperfusion
injuryВ inВ organ transplants, CASS Foundation
$55,000 ($18,817 in 2012)
Dwyer KM
A2 Dairy
$35,000 for 2012–2013 ($17,500 in 2012)
Dwyer KM
Understanding the mechanisms promoting
kidneyВ fibrosis: potential for targeted therapies
toВ slow or prevent progressive kidney failure,
Perpetual Trustees (FR2012/0248)
$90,000 for 2012
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Immunology
Bertolino P, Dwyer KM, Bowen D, Bishop A.
Deciphering mechanisms of liver allograft tolerance,
NHMRC
$502,983 for 2011–2013 ($42,925 in 2012)
• Department of Microbiology & Immunology,
Columbia University, New York, USA
Harshal Nandurkar and Peter Cowan
Role of GRP78 as a novel antithrombotic,
HeartВ Foundation
$130,000 for 2011–2013 ($65,000 in 2012)
• Salk Institute, San Diego, USA
Dr Veena Roberts
Award to attend Purine 2012 conference
Fukuoka,В Japan, Purine 2012
$1,100 for 2012
Dr Veena Roberts
Award to attend American Transplant
CongressВ Boston, USA, Roche
$2,000 for 2012
Collaborations in research
International
• Emory University, Atlanta, USA
• University of Maryland, Baltimore, USA
• University of Padua, Padua, Italy
• University of Pittsburgh, Pittsburgh, USA
• Division of Nephrology, Seoul National University
Hospital, Seoul, Republic of Korea
• Uppsala University, Uppsala, Sweden
National
• Lung Transplant Unit, Alfred Hospital, Prahran, Vic.
• Austin Health, Heidleberg, Vic.
• Australian Centre for Blood Diseases, Alfred
Hospital and Monash University
• Australian National University, Canberra, ACT
• Barwon Health, Geelong, Vic.
• Centenary Institute, Sydney, NSW
• CSIRO-Molecular Health Technologies, Parkville
• Monash Medical Centre, Clayton, Vic.
• University of Minas Gerais, Belo Horizonte, Brazil
• Department of Biochemistry and Molecular
Biology, Monash University, Clayton, Vic.
• Beth Israel Deaconess Medical Center,
Boston,В USA
• Monash Institute of Pharmaceuticals, Monash
University, Parkville, Vic
• Transplantation Biology Research Centre,
Boston,В USA
• Obstetrics & Gynaecology, University of Adelaide,
Adelaide, SA
• Department of Cellular and Molecular Medicine,
University of Bristol, Bristol, United Kingdom
• St. Vincent’s Insitute, Fitzroy
• Cell Transplant and Gene Therapy Institute,
Central South University, Changsha, China
• Department of Biochemistry, Bio21, University
ofВ Melbourne
• Northwestern University, Chicago, USA
• Department of Medicine, University of Melbourne,
Fitzroy, Vic.
• Dresden University, Dresden, Germany
• University of Sydney, Sydney, NSW
• Department of Pediatrics, Surgery & Immunology,
University of Alberta, Edmonton, Canada
• The Walter and Eliza Hall Institute, Parkville, Vic
• Frontier Science Research Center,
KagoshimaВ University, Kagoshima, Japan
• Centre for Transplant and Renal Research,
Westmead Millennium Institute, Westmead, NSW
• Scripps Research Institute, La Jolla, USA
Publications
• Gulbenkian Institute, Lisbon, Portugal
Journal articles
• Loma Linda University, Loma Linda, USA
Chia, J.S, McRae, JL, Cowan, PJ, & Dwyer,
KM (2012). The CD39-adenosinergic axis in the
pathogenesis of immune and nonimmune diabetes.
J Biomed Biotechnol, 2012, 320495.
• University College, London, United Kingdom
• Vanderbilt University, Nashville, USA
• Nantes University, Nantes, France
st vincent’s research report 2012
99
Immunology
Huttinger, Z. M., Milks, M. W., Nickoli, M. S., Aurand,
W. L., Long, L. C., Wheeler, D. G., et al. (2012).
Ectonucleotide triphosphate diphosphohydrolase-1
(CD39) mediates resistance to occlusive arterial
thrombus formation after vascular injury in mice.
Am J Pathol, 181(1), 322–333.
Speaking engagements
Lee, K. F., Lu, B., Roussel, J. C., Murray-Segal, L.
J., Salvaris, E. J., Hodgkinson, S. J., et al. (2012).
Protective effects of transgenic human endothelial
protein C receptor expression in murine models of
transplantation. Am J Transplant, 12(9), 2363–2372.
Transgenic pigs in xenotransplantation. Pig to
Human Xenotransplantation Summit, Changsha,
Aug 2012
Mount, P. F., Gleich, K., Tam, S., Fraser, S. A.,
Choy,В S. W., Dwyer, K. M., et al. (2012). The
outcome of renal ischemia-reperfusion injury
is unchanged in AMPK-beta1 deficient mice.
PLoSВ One, 7(1), e29887.
Pommey S, Lu B, McRae J, Stagg J, Hill P,
Salvaris E, Robson SC, d’Apice AJ, Cowan PJ,
Dwyer KM Liver grafts from CD39-overexpressing
mice are protected from ischemia reperfusion
injury due to reduced numbers of resident CD4(+)
T cells. Hepatology 57:1597–1606 (2012).
Prof Peter Cowan
Genetic engineering to prevent coagulation.
XXIVВ International Congress of the Transplantation
Society, Berlin, Jul 2012
Prospects for xenotransplantation. 4th Australasian
Vaccines and Immunotherapeutics Development
Meeting, Brisbane, May 2012
Xenotransplantation – the inflammatory perfect
storm. Inflammation Conference 2012, Melbourne,
Nov 2012
Dr Karen Dwyer
Purinergic Signalling in Ischaemia Reperfusion Injury.
TSANZ, Canberra, Jun 2012
CD39 & T-cell mediated diabetes. Purines 2012,
Fukuoka Japan 2012
Roberts, V., Lu, B., Rajakumar, S., Cowan, P. J.,
&В Dwyer, K. M. (2013). The CD39-adenosinergic
axis in the pathogenesis of renal ischemiareperfusion injury. Purinergic Signal, 9(2), 135–143.
Prof Harshal Nandurkar
Stagg, J., Thompson, L. F., & Dwyer, K. M. (2012).
Ectonucleotidases in cancer and inflammation.
JВ Biomed Biotechnol, 2012, 951423.
Role of Complement inhibitor therapy in PNH.
InvitedВ Presentation, Federation of ASEAN Societies
ofВ Haematology Meeting, 2012
Wang, Y. M., McRae, J. L., Robson, S. C., Cowan,
P. J., Zhang, G. Y., Hu, M., et al. (2012). Regulatory
T cells participate in CD39-mediated protection
from renal injury. Eur J Immunol, 42(9), 2441–2451.
Role of Complement inhibitor therapy in PNH.
InvitedВ Presentation, Philippines Society of
Haematology of Haematology Meeting, 2012
Wheeler, D. G., Joseph, M. E., Mahamud, S. D.,
Aurand, W. L., Mohler, P. J., Pompili, V. J., et al.
(2012). Transgenic swine: Expression of human
CD39 protects against myocardial injury. J Mol
Cell Cardiol. 52:958–961.
Zhang, Y., Morris, K. L., Sparrow, S. K.,
Dwyer,В K.В M., Enjyoji, K., Robson, S. C., et al.
(2012). DefectiveВ renal water handling in transgenic
miceВ over-expressing human CD39/NTPDase1.
Am J Physiol Renal Physiol, 303(3), F420–430.
Role of fibrinogen in cardiovascular disease.
InvitedВ Presentation, Asia-Pacific Society of
Thrombosis andВ Haemostasis 2012
Neurological manifestations of APS. Invited
Presentation. Australian Society of thrombosis
andВ Haemostasis Annual Meeting 2012
Nandurkar H, Samudra Anushka et al: Purinergic
signalling in APS miscarriages. Asia-Pacific
SocietyВ of Thrombosis and Haemostasis 2012
Nandurkar H, Sharma Anup et al: GRP78 is
aВ novelВ regulator of Haemostasis. Asia-Pacific
SocietyВ of Thrombosis and Haemostasis 2012
st vincent’s research report 2012
100
Intensive Care Unit
The Intensive Care Unit provides all advanced
life-support services for St Vincent’s Hospital
Melbourne as well as management of emergency
resuscitation on the campus and a range of
follow-up programs.
About us
The Intensive Care Unit (ICU) treats between
1,200–1,350 patients annually, approximately
450 of whom undergo cardiac surgery. The unit
isВ accredited for advanced training of intensive
careВ specialists.
The ICU’s research program continues to concentrate
on four areas during 2012. The first relates to acute
lung injury and the role of intravascular thrombosis.
The second looks at outcomes of clinical practice,
the third examines theВ administration of blood
products while the fourth is participation in
theВ Australian and New Zealand Intensive Care
SocietyВ Clinical Trials Group network.
Major projects
• The prevention and treatment of acute lung
injuryВ with nebulised heparin
• Chest tube bleeding associated with
cardiacВ surgery.
• The impact of the intensive care discharge
process on patient outcomes.
• The impact of medical emergency team
onВ hospital mortality across Melbourne
• The nature of emergency calls within a busy
Medical Imaging Department
• The impact of �outlier’ status on subsequent
emergency calls within a hospital
• The impact of age of blood on subsequent
clinicalВ outcomes
• Multi-centre study of old vs newer blood
forВ transfusion in ICU (TRANSFUSE study)
• Multi-centre study of standard versus early
goal-directed therapy in sepsis
• Multi-centre study of normal saline versus hydroxylethyl starch (Voluven) on survival of intensive care
patients requiring fluid resuscitation
• Multi-centre study of standard protein intake
versus extra protein intake on renal outcomes
ofВ intensive care patients
• Multi-centre study of paracetamol vs placebo
inВ the management of fever due to infection
inВ ICUВ patients (HEAT study)
• Multi-centre study of intravenous hydrocortisone
vs placebo in ICU patients with advanced septic
shock (ADRENAL study)
• Point Prevalence Program Surveys
• A follow-up study of survival, quality of life
andВ renal function for patients 3.5 years after
theyВ entered the RENAL study
Dr Dixon’s studies on lung inflammation associated
with cardiopulmonary bypass led to important
publications in 2011 concerning the role of
anticoagulant and prothrombotic agents in the
pathogenesis of lung injury. Building on these earlier
studies of nebulised heparin, a multi-centre, doubleblind, phase III trial of nebulised for the prevention
and treatment of lung injury in critically ill patients
was developed. St Vincent’s ICU is the coordinating
centre for this study and recruitment began in 2012.
The Royal Melbourne Hospital ICU has also joined
the study.
In the area of outcomes of ICU, the major study
examining the impact of the discharge process
on post ICU mortality and morbidity began in
September 2009 and data collection finished in
2010. Presentations of results were made in 2012
and the paper has been submitted for publication.
In a separate study, we examined the impact of
patients admitted to wards other than their home
ward (i.e. outliers) on subsequent emergency calls
for clinical deterioration. We found that such patients
were generally older, had more comorbidities and
required longer hospital admissions. They had
aВ 53% increase in the number of emergency calls.
There has been keen interest in the benefits
andВ complications of administration of blood
products especially red cell products to patients
inВ intensive care. During 2012, we analysed
aВ cohortВ of ICU patients who received a blood
transfusion during their hospital stay. The study
revealed that as the number of units of blood
transfused increased, theВ age of transfused
redВ cellsВ decreased. There was no association
between transfusion and subsequent mortality.
TheВ results were presented in 2012 and aВ paper
hasВ been submitted for publication.
st vincent’s research report 2012
101
Intensive Care Unit
A multi-centre study (TRANSFUSE) will randomise
ICU patients to standard practice transfusion
(olderВ blood) or newer blood to determine the effect
on subsequent mortality. This trial commenced
inВ late 2012.
During 2012 the ICU participated in numerous
multi-centre intervention studies:
• ARISE: A multi-centre study of standard care
vs.В early goal-directed therapy on survival
ofВ patients presenting to the emergency
department with sepsis
• CHEST: A multi-centre, double-blind study
ofВ normal saline vs. hydroxyl-ethyl starch (Voluven)
on survival of intensive care patients requiring fluid
resuscitation. This study was completed in early
2012 and results published. Increased mortality
was seen in patients receiving starch.
• Nephro-Protect: A multi-centre study
ofВ standardВ protein intake vs. extra protein
intakeВ (target 2g/kg/day) on renal outcomes
ofВ intensive care patients.
• ADRENAL: a multi-centre study of intravenous
hydrocortisone vs placebo in patients with
septicВ shock.
• HEAT: a multi-centre study of intravenous
paracetamol vs placebo in patients with fever
secondary to infection.
During 2012 the ICU also participated in multi-centre
observational studies:
• CTG PPP: The ANZICS Clinical Trials Group Point
Prevalence Program. This is a program of crosssectional studies conducted in ICUs across
Australia and New Zealand twice each year.
These �snapshots’ provide information to inform
the design of future studies
• POST-RENAL: A follow-up study of survival,
quality of life and renal function of patients
3.5В years after they entered the RENAL study
(RENAL was a multi-centre study of two intensities
of renal replacement therapy for treatment
ofВ acute renal failure in intensive care patients).
Quality
Patients may experience deterioration in their
condition during their hospital admission. Prompt
recognition and treatment by medical emergency
teams (METs) has led to significant reductions
inВ cardiac arrests and even mortality. These
changesВ are due to a combination of care delivered,
monitoring of events, education and feedback
to ward and treating staff. As a result, we have
continue to show improvements in outcomes
ofВ patients admitted to hospital
Administration of nutrition to patients in ICU
is important as malnutrition is a risk factor
forВ subsequent mortality. Since 2007 we have
participated in an International Quality Improvement
Project which yearly charts the time from admission
to institution of nutrition and the adequacy of calories
administered. The 2012 data show that we function
within the average range for units in Australia. As
aВ result, we have redesigned our feeding protocols
and their impact will be seen in subsequent surveys.
Bowel care is also important within intensive
care.В AВ senior nurse is undertaking a Masters
Program on this topic. Already we have
made changes to the way in which feeds and
medicationsВ are administered and are currently
examining follow-up data.
Staff
A/Prof John D Santamaria, Director,
DepartmentВ Head
Dr Barry Dixon, Intensivist
Dr Antony Tobin, Intensivist
Mr Roger Smith, Research Coordinator
Mrs Jenny Holmes, Research Coordinator
Mr Espedito Faraone, Research Coordinator
Mr David Reid, Data Manager
Service to the wider community
John Santamaria is the Chair of the Victorian
Intensive Care Data Review Committee which
monitors intensive performance and outcomes
inВ Victoria. This Committee is a collaboration
between the Australian and New Zealand
IntensiveВ Care Society (ANZICS) and the Victorian
Department of Health. He is also a member of
theВ Intensive Care Advisory Committee (ICAC)
ofВ theВ Department of Health and a Director of Cabrini
Health Governing Board. Within St Vincent’s,
JohnВ Santamaria is a member of the Mortality &
Clinical Review Committee, the Clinical Research
Support Committee, and the ICT Strategy Clinical
Working Group.
st vincent’s research report 2012
102
Intensive Care Unit
Collaborations in research
• Dr Dixon collaborated with Prof Masud
Behnia (School of Aerospace, Mechanical
and Mechatronic EngineeringВ The University
of Sydney)В to develop a novel HME that
allows nebulisation. As part of this project
he supervisedВ Mr Seyed Pezhman Payami
undertaking a Masters degree.
• Dr Dixon collaborated with Swinburne University
to develop a venous pulse oximeter. As part
ofВ this project he supervised Mr Sovit Baral,
anВ undergraduate biomedical engineering student.
Publications
Journal articles
Papers on Unit Based Research
Dixon B, Santamaria JD, Reid D, et al. The association
of blood transfusion with mortality after cardiac
surgery: cause or confounding? (CME). Transfusion.
Jan 2013;53(1):19–27.
van Tonder FC, Sutherland T, Smith RJ, Chock
JM, Santamaria JD. Medical emergencies in
theВ imaging department of a university hospital:
event and imaging characteristics. Resuscitation.
Jan 2013;84(1):21–24.
Tobin AE, Santamaria JD. Medical emergency
teams are associated with reduced mortality
across a major metropolitan health network
after two years service: a retrospective study
using government administrative data. Crit Care.
2012В OctВ 29;16(5):R210.
Papers in Collaboration with other Researchers
Jelinek MV, Santamaria JD, Thompson DR, Vale MJ.
�Fit for purpose’. The COACH program improves
lifestyle and biomedical cardiac risk factors. Heart.
Nov 2012;98(21):1608.
Duke G, Barker A, Santamaria J, Graco M. Recent
trends in Victorian risk-adjusted in-hospital mortality:
1999–2009. Intern Med J. Nov 2012;42(11):
1218–1223.
Hofstra JJ, Cornet AD, Declerck PJ, Dixon B,
AslamiВ H, Vlaar AP, Roelofs JJ, van der Poll T,
LeviВ M, Schultz MJ. Nebulized fibrinolytic agents
improve pulmonary fibrinolysis but not inflammation
in rat models of direct and indirect acute lung injury.
PLoS One. 2013;8(2):e55262. doi: 10.1371/journal.
pone.0055262. Epub 2013 Feb 7.
Tuinman PR, Dixon B, Levi M, Juffermans NP,
Schultz MJ. Nebulized anticoagulants for acute lung
injury – a systematic review of preclinical and clinical
investigations. Crit Care. 2012 Dec 12;16(2):R70.
doi: 10.1186/cc11325
Marck CH, Weiland TJ, Neate SL, Hickey BB,
Jelinek GA. Personal attitudes and beliefs regarding
organ and tissue donation: a cross-sectional survey
of Australian emergency department clinicians.
Prog Transplant. 2012 Sep;22(3):317–22
Marck CH, Weiland TJ, Neate SL, Hickey BB,
Jelinek GA. Australian emergency doctors’
and nurses’ acceptance and knowledge
regardingВ brain death: a national survey.
Clin Transplant. 2012 May–Jun;26(3):E254–60.
Neate S, Marck CH, Weiland TJ, Cunningham
N, Hickey BB, Dwyer BM, Jelinek GA. Australian
emergency clinicians’ perceptions and use of the
GIVE Clinical Trigger for identification of potential
organ and tissue donors. Emerg Med Australas.
2012 Oct;24(5):501–9.
Jelinek GA, Marck CH, Weiland TJ, Neate SL,
Hickey BB. Organ and tissue donation-related
attitudes, education and practices of emergency
department clinicians in Australia. Emerg Med
Australas. 2012 Jun;24(3):244–50.
Marck CH, Jelinek GA, Neate SL, Dwyer BM, Hickey
BB, Weiland TJ. Resource barriers to the facilitation
of organ and tissue donation reported by Australian
emergency clinicians. Aust Health Rev. 2013
Feb;37(1):60–5. Papers published by ANZICS Clinical Trials
Group (in which ICU participated)
Myburgh J, Li Q, Heritier S, Dan A, Glass P,
Crystalloid Versus Hydroxyethyl Starch Trial
Management C. Statistical analysis plan for the
Crystalloid Versus Hydroxyethyl Starch Trial (CHEST).
Critical care and resuscitation: Journal of the
Australasian Academy of Critical Care Medicine.
Mar 2012;14(1):44–52.
Davies AR, Morrison SS, Bailey MJ, et al.
AВ multicenter, randomized controlled trial
comparingВ early nasojejunal with nasogastric
nutrition in critical illness. Critical care medicine.
Aug 2012;40(8):2342–2348.
st vincent’s research report 2012
103
Intensive Care Unit
Speaking engagements
Annual Scientific Meeting on Intensive Care,
Adelaide October 2012
John Santamaria
• Plenary lecture on the outcomes of patients
following ICU discharge
• Presentation on outcomes of �outlier’ patients
inВ hospital (Best Paper award)
Roger Smith
• Fluid therapy using bicarbonate-containing
crystalloid solutions after cardiac surgery
Espedito Faraone
• Survival after hospital discharge for patients
thatВ had in-hospital medical emergency call
Antony Tobin
• Mortality is associated with transfusion volume
notВ red blood cell age.
American Thoracic Society, San Francisco,
MayВ 2012
Antony Tobin
• Timing of blood transfusion in ICU patients
andВ association with mortality.В A Tobin, A Ghosh,
DВ Reid, J Santamaria .ATS San Francisco 2012
st vincent’s research report 2012
104
INFECTIOUS DISEASES
St Vincent’s has a comprehensive infectious
diseases department with services provided
byВ specialist infectious disease physicians.
ABOUT US
Services provided by the Infectious Diseases
department include HIV medicine, tuberculosis,
exotic and travel diseases, needle stick injury
management program, post surgical infections,
general infections and PUOs, and post screening
refugee care.
PUBLICATIONS
Journal articles
Darby J, Black J, Morrison D, Buising K. An
information management system for patients with
tuberculosis: usability assessment with end-users.
Stud Health Technol Inform. 2012;178:26-32.
STAFF
Gordon CL, Whiting SE, Haran G, Ward A,
Coleman M, Baird C, Jeremiah CJ, Mileva
M, Davis JS, Warren LJ, Ellis DH, Currie BJ.
Entomophthoromycosis caused by Basidiobolus
ranarum in tropical northern Australia. Pathology
2012; 44(4): 375-8
A/Prof Peter Stanley, Director Infectious Diseases
Conference publications
Dr John Daffy, Head of Infectious Diseases Clinics
Speaking engagements
Dr Kirsty Buising, Infectious Diseases Consultant
Kobayashi N, Davis J, Jeremiah C, Hughes J,
PerryВ G, Tong S. Oral presentation and poster at
the ASM of the Australian and New Zealand Society
of Nephrology, Auckland, 2012: High Incidence of
Staphylococcus aureus Bacteraemia in Indigenous
Haemodialysis Patients is not a result of Catheter
Related Infections.
Dr Craig Aboltins, Infectious Diseases Consultant
Dr Adam Jenny, Infectious Diseases Consultant
Dr Jonathan Darby, Infectious Diseases Consultant
Dr Trish Peel, Infectious Diseases Consultant
Dr Amy Crowe, Infectious Diseases Registrar
GRANTS
Buising KL, Marshall C,Richards MJ,
Robertson M
Models for hospital antimicrobial stewardship,
NHMRC partnership grant, Victorian Infectious
Diseases service, Royal Melbourne Hospital;
Epworth Hospital; Department Human Services
Quality branch; and Therapeutic Guidelines
$1.12 million for 2011–2014
Thompson JS, Whiting SE, Jeremiah CJ, Baird R.
Poster at Australian Society for Infectious Diseases
Conference, Fremantle, 2012: Candidemia in
the top end of the Northern Territory, Australia:
A retrospective audit of incidence, species and
susceptibilities.
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105
MEDICAL IMAGING
The Medical Imaging Department supports
clinical research within St Vincent’s Hospital
andВ undertakes Department initiated projects.
Dr Con Tartaglia, VMO
ABOUT US
Prof Oliver Hennessy, Honorary Radiologist
The Medical Imaging Department provides clinical
support to other departments as well as actively
supporting many research projects within the
hospital, in particular Clinical Neurosciences,
Orthopaedics and Oncology. Medical Imaging
Department is a training department for doctors,
technician and nurses, as well as having
academic links to the University of Melbourne
andВ MonashВ University.
Dr P Mossop, Honorary Radiologist
Many of the senior doctors are involved with
research projects involving MRI, CT, Nuclear
medicine and Interventional Radiology.
Dr Frans Van Tonder, Registrar
STAFF
Dr Xavier Yu, Registrar
A/Prof Stephen Schlicht, Director of Medical
Imaging Department, Director of St Vincent’s Private
Radiology and Director of Nuclear Medicine.
Dr Neil Liddell, General Manager
Dr Duncan Mark Brooks, Consultant Radiologist
A/Prof Peter Brotchie, Consultant Radiologist
Dr R. Brownlee, Honorary Radiologist
A/Prof J. Cawson, Honorary Radiologist
Dr Georgia Box, Registrar
Dr Reade De Leacy, Fellow
Dr Angela Galvin, Registrar
Dr David Learmont-Walker, Registrar
Dr Hamish McKay, Registrar
Dr Raymond Shafik-Eid, Registrar
Dr Jane Watts, Registrar
Dr Eric Yong, Registrar
Mr Alan Malbon, Chief Radiographer
Mr Russell Booth, Chief Nuclear Medicine
Technologist & Quality Coordinator
Dr Ashu Jhamb, Consultant Radiologist
Mr Mark Lourensz, Chief Magnetic Resonance
Imaging Technician
Dr Wai Kit Lee, Consultant Radiologist
Ms Zoe Campbell, Research Coordinator
Dr Ross McKellar, Consultant Radiologist
Dr Marcus Pianta, Consultant Radiologist
Dr Hannah Rouse, Consultant Radiologist
Dr Melanie Seale, Consultant Radiologist
Dr Tom Sutherland, Consultant Radiologist
Dr Nicholas Trost, Consultant Radiologist
Dr Kelvin Yap, Consultant Radiologist
Dr Kim Taubman, Consultant Nuclear
MedicineВ Physician
MAJOR PROJECTS
A/Prof Peter Brotchie
Brotchie P, Seixas S. “Investigating navigational
performance using functional MRI” (2006-2013).
Brotchie P, Kumar J. “Arterial Spin Labelling
in Dementia” (2010-ongoing).
Brotchie P, Ramaseshan G. “Changes in Resting
State fMRI due to Lithium” (2012-ongoing).
Dr Michael Holt, VMO
Anderson AJ, Carpenter RHS, Brotchie P. “Getting
back on track after the unexpected happens:
decision making in predictable and unpredictable
environments”. (2012-2014).
A/Prof Andrew Little, VMO
A/Prof Andrew Little
Dr Keat Low, VMO
Little A, Ryan M, Sutherland T. “Diffusion weighted
hepatic MRI versus sonography for the detection of
hepatocellular carcinoma in a screening population.”
(2011-ongoing).
Dr Shalini Amuktomawa, VMO
Dr Kirsten Gordon, VMO
Dr Belinda Lui, VMO
Dr Kirti Mehta, VMO
Dr Carol Standford-Starr, VMO
st vincent’s research report 2012
106
MEDICAL IMAGING
Dr Tom Sutherland
COLLABORATIONS IN RESEARCH
Little A, Ryan M, Sutherland T. “Diffusion weighted
hepatic MRI versus sonography for the detection of
hepatocellular carcinoma in a screening population.”
(2011-ongoing).
RMIT, Bundoora, Victoria.
QUALITY
Information for Patients Requiring a Contrast CT
This project continued on the work commenced
in 2012. A pamphlet was produced containing
the information requested by patients in the initial
interviews.
The pamphlet used pictographs to show various
aspects of the preparation and examination.
There was minimal use of text and the test used
was targeted to the health literacy of our patient
population.
The pamphlet was then tested on a group of
patients. The patients found the pamphlet easy
to follow and thought the instructions were clear.
There was one aspect regarding the contrast
preparation that a small number of patients found
confusing. This has been addressed. The pamphlet
is now in use as part of the patients’ preparation
instructions for CT. The next phase is to develop a
library of pictographs which can be used to produce
pamphlets for other imaging investigations where
patient preparation is critical.
GRANTS
Anderson AJ, Carpenter RHS, Brotchie P
Getting back on track after the unexpected happens:
decision making in predictable and unpredictable
environments, ARC Project Grant DP120100651.
Administered by University of Melbourne
$240,000 for 2012–2014
University of Melbourne, Carlton, Victoria.
PUBLICATIONS
Journal Articles
Mr Russell Booth
Michael M, Cullinane C, Hatzimihalis A, O’kane C,
Milner A, Booth R, Schlicht S, Clarke SJ, Francis
P. (2012). Docetaxel pharmacokinetics and its
correlation with two in vivo probes for cytochrome
P450 enzymes: the C(14)-erythromycin breath
test and the antipyrine clearance test Cancer
chemotherapy and pharmacology, Vol.69(1):125-35
Dr Wai Kit Lee
Lee WK, Van Tonder F, Tartaglia CJ, Dagia C,
Cazzato RL, Duddalwar VA, Chang SD. (2012).
CT appearances of abdominal tuberculosis. Clinical
Radiology; 67(6):596-604
Mr Mark Lourensz
Pianta M, Lourensz M, Trost, N. (2012) Bone
and Soft Tissue Tumour Imaging: An Overview.
Magnetom Flash: The Magazine of MRI: 2/2012
RSNA Edition: 50-57.
Dr Belinda Lui
Lui B, Sutherland T, Lasoki A, Hennessy O. (2012).
Small bowel Crohns disease: MRI Pictorial Essay,
JMIRO; 56 (3):295-310
Dr Marcus Pianta
Pianta M, Lourensz M, Trost, N. (2012) Bone
and Soft Tissue Tumour Imaging: An Overview.
Magnetom Flash: The Magazine of MRI: 2/2012
RSNA Edition: 50-57.
st vincent’s research report 2012
107
MEDICAL IMAGING
A/Prof Stephen Schlicht
Yii SW, Schlicht S, Taubman K, Kong WN. (2012)
Pertechnetate thyroid scan and thyroid function
tests in a case of Sorafenib induced thyroiditis.
TheВ Internet Journal of Nuclear Medicine, August 3,
2012, Vol.5(2)
Michael M, Cullinane C, Hatzimihalis A, O’kane C,
Milner A, Booth R, Schlicht S, Clarke SJ, Francis
P. (2012). Docetaxel pharmacokinetics and its
correlation with two in vivo probes for cytochrome
P450 enzymes: the C(14)-erythromycin breath
test and the antipyrine clearance test Cancer
chemotherapy and pharmacology, Vol.69(1): 125-35
Dr Melanie Seale
Samir AE, Vij A, Seale MK, Desai G, Halpern E,
Faquin WC, Parangi S, Hahn PF, Daniels GH. (2012).
Ultrasound-guided percutaneous thyroid nodule
core biopsy: clinical utility in patients with prior
nondiagnostic fine-needle aspirate, Thyroid: Official
journal of the American Thyroid Association, 2012,
Vol.22(5), pp.461-7
Dr Tom Sutherland
Sutherland T, Yap K, Liew E, Tartaglia C, Pang
M, Trost N. (2012). MRI features of Primary CNS
lymphoma: A review of 30 patients, JMIRO: 56(3):
295-310
Yap K, Sutherland T, Liew E, Tartaglia C, Pang M,
Trost N, MRI features of Primary CNS lymphoma:
AВ pictorial essay, JMIRO 2012: 56(2):179-186
Lui B, Sutherland T, Lasoki A, Hennessy O. (2012)
Small bowel Crohns disease: MRI Pictorial Essay,
JMIRO: 56(3): 295-310
Caputo C, Sutherland T, Farish S, McNeill P, Ng KW,
Inder WJ. (2012) Gender Differences in presentation
and outcome of non-functioning pituitary
macroadenomas. Clin Endocrinol 2012 Aug 2012
epub ahead of print
Yong XZ, Sutherland T. (2012). Making sense of MRI
lumbar spine. Aust Fam Physician: 4(11): 887-890
Dr Con Tartaglia
Sutherland T, Yap K, Liew E, Tartaglia C, Pang
M, Trost N. (2012). MRI features of Primary CNS
lymphoma: A review of 30 patients, JMIRO: 56(3):
295-310
Lee WK, Van Tonder F, Tartaglia CJ, Dagia C,
Cazzato RL, Duddalwar VA, Chang SD. (2012).
CT appearances of abdominal tuberculosis.
ClinicalВ Radiology; 67(6):596-604
Yap K, Sutherland T, Liew E, Tartaglia C, Pang M,
Trost N, MRI features of Primary CNS lymphoma:
AВ pictorial essay, JMIRO 2012: 56(2):179-186
Dr Kim Taubman
Yii SW, Schlicht S, Taubman K, Kong WN. (2012)
Pertechnetate thyroid scan and thyroid function
tests in a case of Sorafenib induced thyroiditis.
TheВ Internet Journal of Nuclear Medicine, August 3,
2012, Vol.5(2)
Dr Nicholas Trost
Pianta M, Lourensz M, Trost, N. (2012) Bone
and Soft Tissue Tumour Imaging: An Overview.
Magnetom Flash: The Magazine of MRI: 2/2012
RSNA Edition: 50-57
Sutherland T, Yap K, Liew E, Tartaglia C, Pang
M, Trost N. (2012). MRI features of Primary CNS
lymphoma: A review of 30 patients, JMIRO: 56(3):
295-310
Yap K, Sutherland T, Liew E, Tartaglia C, Pang M,
Trost N, MRI features of Primary CNS lymphoma:
AВ pictorial essay, JMIRO 2012: 56(2):179-186
Dr Frans Van Tonder
Lee WK, Van Tonder F, Tartaglia CJ, Dagia C,
Cazzato RL, Duddalwar VA, Chang SD. (2012).
CT appearances of abdominal tuberculosis.
ClinicalВ Radiology; 67(6):596-604
Dr Kelvin Yap
Sutherland T, Yap K, Liew E, Tartaglia C, Pang
M, Trost N. (2012). MRI features of Primary CNS
lymphoma: A review of 30 patients, JMIRO: 56(3):
295-310
Yap K, Sutherland T, Liew E, Tartaglia C, Pang M,
Trost N, MRI features of Primary CNS lymphoma:
AВ pictorial essay, JMIRO 2012: 56(2):179-186
Prof Oliver Hennessy
Lui B, Sutherland T, Lasoki A, Hennessy O. (2012).
Small bowel Crohns disease: MRI Pictorial Essay,
JMIRO: 56 (3): 295-310
st vincent’s research report 2012
108
MEDICAL IMAGING
Conference Presentations
Dr Marcus Pianta
Walter P, Maksymowych, Ulrich Weber, Marcus
Pianta, Robert GW Lambert, “Semi-Quantitative
Assessment of Bone Marrow Edema and SynovitisEffusion in Osteoarthritis with the Knee Inflammation
MRI Scoring System: A Target Lesion Based
Methodology”, American College of Rheumatology
Annual Meeting, Washington DC, November 2012.
Dr Wai Kit Lee
Muir T, Lee WK, Harding J, Schlicht S. “Ectopic
Parathyroid Adenoma in the Pyriform Fossa”, Annual
Scientific Meeting of the Australian and New Zealand
Society of Nuclear Medicine (ANZSNM 2012),
Melbourne, April 2012.
A/Prof Stephen Schlicht
Muir T, Lee WK, Harding J, Schlicht S. “Ectopic
Parathyroid Adenoma in the Pyriform Fossa”, Annual
Scientific Meeting of the Australian and New Zealand
Society of Nuclear Medicine (ANZSNM 2012),
Melbourne, April 2012.
Speaking engagements
Dr Marcus Pianta
“Musculoskeletal Tumour Mimics” Royal Australian
and New Zealand College of Radiologists, Victorian
Branch Monthly Scientific Meetings (MSM), April
2012.
A/Prof Stephen Schlicht
“Approach to Bone and Soft Tissue Tumour
Diagnosis – Traps and Pitfalls”, Royal Australian
and New Zealand College of Radiologists, Victorian
Branch Monthly Scientific Meetings (MSM), April
2012.
st vincent’s research report 2012
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Mental Health
The St Vincent’s Mental Health Research Unit
maintains an active research program with
aВ primary focus on clinically relevant research
that translates into optimising the care of people
with a mental illness. We have a multidisciplinary
focus and particularly value obtaining the
experiences of consumers and their families/
carers.
Major projects
About us
The Body Image and Eating Disorder Treatment
andВ Recovery Service (BETRS), a Department
of Health-funded collaboration between St Vincent’s
Hospital and Austin Health, is continuing a 2-year
longitudinal study of the efficacy of its program.
The St Vincent’s Mental Health Research Unit
isВ nested within a small academic department
affiliated with the University of Melbourne’s
Department of Psychiatry, School of Nursing
andВ Social Work and School of Population Health.
Our two broad areas of core research are (1)
optimising mental health care and (2) integrating
physical and mental health. The Academic Unit
for Psychiatry of Old Age is part of the St Vincent’s
Aged Mental Health service and is a significant
collaborative partner of the St Vincent’s Mental
Health Research Unit. Our specific research activities
concentrate on prevention and early intervention,
new and innovative models of care, health promotion
and education and service improvement.
The majority of our research is underpinned
byВ aВ multidisciplinary collaborative approach
andВ weВ areВ currently engaged in a number
of research initiatives with other St Vincent’s
departments andВ external organisations,
nationallyВ and internationally. Over the past
12В months, ourВ research has particularly
focussedВ onВ service evaluation, healthy lifestyle
interventions, theВ psychological management
ofВ chronic diseaseВ patients, and a national survey
ofВ highВ impact psychosis.
In addition to comprehensive undergraduate
andВ postgraduate teaching programs, we have
a strong commitment to research support,
development and training of both clinical and
academic staff. This includes weekly journal clubs
and Eric Seal seminars, monthly research clubs
andВ a research clinic.
A research portfolio system was formalised in 2012.
Each portfolio meets independently of the main
Research and Academic Group (RAG). The portfolios
report directly to RAG and present their research
and publications on a monthly basis. There were
numerous research activities across the portfolios
inВ 2012. Some highlights include the following:
The Early Psychosis program is continuing
itsВ longitudinal follow-up of our early psychosis
cohort. This will facilitate a better understanding
ofВ early psychosis and its optimal management.
The International Mental Health Unit established
Memorandums of Understanding with several
countries in relation to community mental health
projects, including China, Japan, and Qatar.
Consultation Liaison (CL) Psychiatry is conducting
a 12-month follow-up study of anxiety, depression,
and coping in renal dialysis patients. Other current
CL projects include the pilot evaluation of a mental
health intervention for young people with Type 1
diabetes, and an ARC-funded randomised control
trial examining a mindfulness intervention for patients
undergoing total joint replacements.
Awards and Achievements
Invited member, Schizophrenia International
Research Society International Advisory
Committee (2012–2015) – Prof David Castle
Melissa Petrakis, Steve Penno, JuliaВ Oxley,
SimonВ Laxton, Hannah Bloom, BridgetВ Hamilton,
Graeme Doidge, Ajit Selvendra, DominikaВ Baetens,
Bella Anderson, Angela Spiller, Michael Nolan,
Megan Svenson, Jane Dowling and DavidВ Castle.
Early Psychosis Program Implementation
and Evaluation. Exceptional Care – Research
Excellence. Health Quality Awards, St Vincent’s
Health Australia, Sofitel on Collins, Melbourne,
23В May.
st vincent’s research report 2012
110
Mental Health
Quality
A departmental research review of the research
unit was conducted by Prof Ian Everall, Head
of Dept of Psychiatry, University of Melbourne.
Although excellent feedback was provided,
several recommendations were made in relation
toВ promoting the growth of the research unit.
TheseВ will be addressed in 2013. A copy of
theВ report is attached.
Mr Sam Mancuso, Research Coordinator
&В Honorary Fellow 1.0EFT
Dr Melissa Petrakis, Research Fellow 0.4EFT
Dr Eleanor Curran, Research Registrar 0.4EFT
Ms Nga Tran, Senior Pharmacist & Honorary Fellow
0.1EFT
Dr Gaye Moore, Coordinator, Frameworks for Health
1.0EFT
Frameworks for Health conducted a pilot study
ofВ the ACCORD optimal health program for carers
ofВ individuals with stroke. Pilot data are promising
and a NHMRC project grant will be submitted in
2013 to conduct a larger randomised control trial.
Mr Daryl Oehm, Manager VTPU 0.2EFT
Consultation Liaison Psychiatry submitted a
business plan for a new unit in the inpatient building
for the care of cognitively disturbed elderly patients.
A 1-year trial to implement and evaluate the unit
wasВ requested.
Students
Collaboration was established with the Melbourne
Dental School, University of Melbourne, with the aim
of developing a screening measure for prosthodontics
patients with body dysmorphic disorder.
Our collaboration with orthopaedics, diabetes,
cardiology, oncology, renal, and neurology at
St Vincent’s are helping enhance mental health
careВ in these physical health settings.
Staff
Prof David Castle, Psychiatry Chair 1.0EFT
A/Prof Mike Salzberg, Director of CL Psychiatry
&В Associate Professor 0.5EFT
Ms Casey O’Brien, Psychologist 0.1EFT
Dr Justin Kuay, Senior Psychiatry Registrar, 0.2EFT
Dr Evrim March, Senior Neuropsychologist, 0.5 EFT
James LeBas, PhD Student
Sam Mancuso, PhD Student
Kaveh Monshat, PhD student
Service to the wider community
• Adult Mental Health Information Development
Expert Advisory Panel, member – Prof Tom Trauer
• Advisory Committee China-Australia Community
Mental Health Program, member – A/Prof Chee Ng
• Member, Australia-India Advisory Committee for
Community Mental Health at the Ministry of Health
and Family Welfare, 2011 – A/Prof Chee Ng
• Member, Mental Health Sub-Technical
WorkingВ Group Ministry of Health Cambodia
– A/Prof Chee Ng
A/Prof Chee Ng, Director of International Unit 0.1EFT
• Asia Australia Mental Health Executive,
member – A/Prof Chee Ng
Prof Tom Trauer, Honorary Professorial Fellow
0.1EFT
• International Affairs Working Group RANZCP,
member – A/Prof Chee Ng
A/Prof Peter Bosanac, Director Clinical Services
0.3EFT
• International League Against Epilepsy
(ILAE)В Faculty of 1000, member
– A/Prof Michael Salzberg
Dr Bridget Hamilton, Clinical Nurse Consultant
0.2EFT
Dr Jeremy Couper, Senior Lecturer 0.2EFT
• International Psycho-oncology Society (IPOS),
member – Dr Jeremy Couper
Dr Prem Chopra, Consultant Psychiatrist 0.2EFT
• Mental Health Foundation of Australia (VIC),
honorary treasurer – Dr Peter Bosanac
Dr Carol Silberberg, Consultant Psychiatrist
&В Lecturer 0.4EFT
• National Mental Health Information Development
Expert Advisory Panel, member – Prof Tom Trauer
Dr Kaveh Monshat, Lecturer 0.3EFT
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Mental Health
• Victorian Clinical Nurse Consultant Forum
– Dr Bridget Hamilton
• Psycho-oncology Co-operative Research
GroupВ (POCOG) Executive Committee, member
– Dr Jeremy Couper
• RANZCP Section of Social and Cultural Psychiatry,
member and secretary – Dr Prem Chopra
• Study of High Impact Psychoses (SHIP), Technical
Advisory group member – Prof David Castle
• Member, RANZCP Victorian Branch Committee
(2012–2013) – Prof David Castle
• Member, Victorian Ministerial Eating Disorders
Taskforce – Prof David Castle
• St Vincent’s Hospital Human Research
EthicsВ Committee A (HREC-A), member
– Prof Tom Trauer
• World Psychiatric Association Section of
Epidemiology and Public Health, associate
member – Dr Prem Chopra
• Psychiatrist (pro bono), Asylum Seeker Resource
Centre, West Melbourne – Dr Carol Silberberg
• Pacific Rim College of Psychiatrists Executive
Committee, member – A/Prof Chee Ng
• Consortium Member Mental Health in Multicultural
Australia Project (MHiMA) – Mr Daryl Oehm
• Member Mental Health in Multicultural Victoria
(MHiMV), Mental Health Reform Strategy (2012)
– Mr Daryl Oehm
• Member, Migrant Mental Health Taskforce, Mental
Health Reform Strategy (2011) – Dr Prem Chopra
• Member, Recovery Framework Advisory
Committee, Department of Health Victoria
(2010–2011) – Dr Prem Chopra
• Associate Member, World Psychiatric Association
Section of Epidemiology and Public Health
– Dr Prem Chopra
Grants
E. March, S.L. Rossell & D.J. Castle
Cognitive remediation in first episode psychosis:
a pilot study, St Vincent’s Hospital Research
Endowment Fund
$15,000 for 2 years
L Abel, S Rossell, D Castle & A Phillipou
Investigating the neurobiological and cognitive
features of Anorexia Nervosa, The Jack Brockhoff
Foundation
26,973 for 1.5 years
Castle D
Development of a joint psycho-oncology clinical
research program, Victorian Comprehensive
CancerВ Centre
$10,000
Mancuso S, Castle D
CRUfAdschools Body Image Project,
AndrewsВ Foundation
$10,000
Martin T, Worrall-Carter L, Thompson DR, SkiВ C,
Wilson A, Castle D, Whitbourn R, Shulkes A,
Hiller J, Thoeming A
Building Collaborative Research with Specific Focus
on Cardiovascular Health, Department of Innovation
Industry, Science & Research Collaborative Research
Network (CRN)
$7,915,646
J Couper, A Pollard, D Castle
Phase 1 pilot of a Mindfulness-Based Stress
Reduction Intervention for Head and Neck Cancer
patients receiving treatment of curative intent.,
BEYOND BLUE LIMITED (ACN 093 865 840),
The beyondblue Victorian Centre of Excellence in
Depression, Anxiety and Related Disorders (bbVCoE)
$150,000 for 2012–2014 ($75,000 in 2012)
E March, S Rossell, D Castle
Research Endowment Fund (Cognitive Remediation
in First Episode Psychosis), St Vincent’s Hospital
$14,922 for 2012
C Ng
Application number AJF12105 – Mental Health
Leadership Development and Research Exchange
Program, Australia-Japan Foundation (AJF) grants
round 2012–13
$33,000 for 1 year ($10,000 in 2012)
C Ng
Mental Health Capacity Building and Leaders
Exchange in Asia Pacific (R10-040)., Australian
Leadership Awards Round 10 Department
ofВ ForeignВ Affairs and Trade
$114,950 for 2012
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J Fraser, C Ng, Brigid Ryan
Building community mental health through
strategicВ public partnerships in Melanesia
(Fiji,В Solomon Islands)., AusAID Pacific Public
SectorВ LinkagesВ Program
$356,150 for 2 years ($100,000 in 2012)
• La Trobe University, Bundoora, Victoria
B Hamilton
Employing Recovery-oriented Practice Framework,
Nurse Policy Branch, Department of Health
$80,000 for 2011–2013 ($10,000 in 2012)
• Swinburne University of Technology, Melbourne
B Hamilton, Jane Pirkis, Rachael Duncan
Evaluation of NMHP, Nurses Board of Victoria
$50,000 for 2010–2012 ($28,000 in 2012)
D Castle, NT Lautenschlager, D Thompson,
Chantal Ski, John Rolley, Arthur Hsueh,
GayeВ Moore
Improving the mental health of carers of stroke
patients: A pilot study of Australian Care
Coordination (ACCORD), St Vincent’s Research
Endowment Fund
$20,000 (via St Vincent’s adult psychiatry) for 2012
• Monash University, Melbourne
• Monash Medical Centre, Melbourne
• Peter MacCallum Cancer Centre, Melbourne
• St Vincent’s Hospital, Sydney
• Sydney University, Sydney
• University of Newcastle, Newcastle
• University of Melbourne, Melbourne
• Melbourne Dental School,
TheВ UniversityВ ofВ Melbourne, Melbourne
• University of New South Wales, New South Wales
• University of Western Australia, Western Australia
• Victorian Department of Human Services,
Melbourne
• beyondblue
• Mental Illness Fellowship
• SANE
Collaborations in research
• MIND
International
• Centre for International Mental Health, School
ofВ Population Health, The University of Melbourne
• Boston University, USA
• Institute of Mental Health,
UniversityВ ofВ Peking,В China
• Guangdong Mental Health Institute, China
• National Center for Neurology and Psychiatry,
Japan
• Institute of Psychiatry, University of Oslo
• Directorate General of Health Services,
MinistryВ ofВ Health and Family Welfare, India
• Chinese University of Hong Kong
• Hamad Medical Coorporation, Qatar
• University of Washington, Seattle, USA
• Leicester University, United Kingdom
National
• Alfred Psychiatry Research Centre, Melbourne
• Clinical Research Unit for Anxiety Disorders,
Sydney, New South Wales
• Curtin University, Karawara, Western Australia
• Goulburn Valley Area Mental Health Service
Publications
Books
Castle D.J. Copolov D., Wykes T, Mueser K.
(Eds.), 2012. Pharmacological and Psychosocial
Treatments in Schizophrenia, 3 ed. Informa
Healthcare, London.
Castle DJ, Hood S, Starcevic V. (Eds.), 2012.
Anxiety Disorders: Current Understanding, Novel
Treatments, 3 ed. Australian Postgraduate Medicine,
Melbourne.
Castle DJ, Murray R, D’Souza D. (Eds.), 2012.
Marijuana and Madness, 2 ed. Cambridge University
Press, Cambridge.
Hamilton B, Bicharia E, Roper C, Easton, C. 2012.
Gaining Strength: Consumer experiences of case
management with the Strengths Model. St.Vincent’s
Mental Health, Fitzroy, Victoria.
• Deakin University, Melbourne
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Book chapters
Castle, D.J., Olver, J., Crino, R., 2012. Treatment
advances in OCD, in: Castle, D.J., Hood, S.,
Starcevic, V. (Eds.), Anxiety Disorders: Current
Understanding, Novel Treatments, 3 ed. Australian
Postgraduate Medicine, Melbourne, pp. 137–152.
Castle, D.J., Tran, N., Alderton, D., 2012.
Psychopharmacological management of
schizophrenia and related disorders, in: Castle,
D.J., Copolov, D., Wykes, T., Mueser, K. (Eds.),
Pharmacological and Psychosocial Treatments
inВ Schizophrenia, 3 ed. Informa Healthcare,
London, pp. 1–31.
Castle, D.J., Tran, N., Bosanac, P., Alderton,В D.,
2012. Management of acute behaviouralВ disturbance
in psychosis, in: Castle, D.J., Copolov, D.,
Wykes, T., Mueser, K. (Eds.), Pharmacological
and Psychosocial Treatments in Schizophrenia,
3 ed. Informa Healthcare, London, pp. 119–136.
Castle, D.J., Wykes, T., Bosanac, P., Knoesen,В N.,
2012. Depression and anxiety in schizophrenia,
in: Castle, D.J., Copolov, D., Wykes, T., Mueser,
K. (Eds.), Pharmacological and Psychosocial
Treatments in Schizophrenia, 3 ed. Informa
Healthcare, London, pp. 72–90.
Copolov, D., Castle, D.J., 2012. The management
of negative symptoms, in: Castle, D.J., Copolov, D.,
Wykes, T., Mueser, K. (Eds.), Pharmacological and
Psychosocial Treatments in Schizophrenia, 3 ed.
Informa Healthcare, London, pp. 47–58.
Hamilton, B., 2012. Strengths Case Management,
in: Meadows, G., Farhall, J., Fossey, E., Grigg, M.,
McDermott, F., Singh, B. (Eds.), Mental health in
Australia: collaborative community practice, 3 ed.
Oxford University Press, South Melbourne, VIC, pp.
434–437.
James, W., Castle, D.J., 2012. Addressing
cannabis use in people with psychosis, in: Castle,
D.J., Murray, R., D’Souza, D. (Eds.), Marijuana
and Madness, 2 ed. Cambridge University Press,
Cambridge, pp. 225–233.
James, W., Mueser, K., Castle, D.J., 2012.
Substance abuse comorbidity in schizophrenia,
in:В Castle, D.J., Copolov, D., Wykes, T., Mueser,В K.
(Eds.), Pharmacological and Psychosocial
Treatments in Schizophrenia, 3 ed. Informa
Healthcare, London, pp. 107–118.
Lautenschlager, N., Rabins, P., Castle, D.J., 2012.
Schizophrenia in late life, in: Castle, D.J., Copolov,
D., Wykes, T., Mueser, K. (Eds.), Pharmacological
and Psychosocial Treatments in Schizophrenia,
3 ed. Informa Healthcare, London, pp. 202–213.
Silberberg, C., Castle, D.J, Koethe, D., 2012.
Cannabis, cannabinoids, and bipolar disorder,
in: Castle, D.J., Murray, R., D’Souza, D. (Eds.),
Marijuana and Madness, 2 ed. Cambridge University
Press, Cambridge, pp. 129–136.
Trauer, T., 2012. HoNOS in routine outcome
assessment: the Australian experience, in: Erlicher,
A., Lora, A., Monzani, E., Parabiaghi, A. (Eds.),
Health of the Nation Outcome Scales HoNOS. Il
Pensiero Scientifico Editore, Rome, pp. 1–16.
Journal articles
Addis, S., Sherwood, D., Mace, W., Mancuso, S.G.,
Koloth, R., Castle, D.J., 2012. A naturalistic study
of pharmacological management of behavioural
disturbance in psychosis. Journal of Psychiatric
Intensive Care 8(02), 120–125.
Castle, D.J., 2012. Is it appropriate to treat people
at high-risk of psychosis before first onset?–No.
TheВ Medical journal of Australia 196(9), 557.
Castle, D.J., Bosanac, P., 2012. Depression and
schizophrenia. Advances in Psychiatric Treatment
18(4), 280–288.
Castle, D.J., 2012. Schizoaffective disorder.
Advances in Psychiatric Treatment 18(1), 32–33.
Castle, D.J., 2012. The truth, and nothing but
the truth, about early intervention in psychosis.
Australian and New Zealand Journal of Psychiatry
46(1), 10–13.
Castle, D.J., Baker, A., Richmond, R., Filia, S.,
Harris, D., Pirola-Merlo, A.J., 2012. Varenicline plus
healthy lifestyles in people with a psychotic disorder.
Annals of Clinical Psychiatry 24(4), 285–291.
Castle, D.J., Piterman, L., Berk, L., 2012. Difficultto-treat depression. MJA Open 1(S4), 4–5.
Chan, E.W., Kong, D., Knott, J.C., Castle, D.J.,
2012. Ethical issues in researching interventions
forВ behavioral disturbance in psychotic disorders.
Asia-Pacific Psychiatry 4(2), 140–143.
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Contreras, N., Rossell, S.L., Castle, D.J.,
Fossey, E., Morgan, D., Crosse, C., Harvey, C.,
2012. Enhancing Work-Focused Supports for
People withВ Severe Mental Illnesses in Australia.
Rehabilitation Research and Practice 2012, 1–8.
Cooper, J., Mancuso, S.G., Borland, R., Slade, T.,
Galletly, C., Castle, D.J., 2012. Tobacco smoking
among people living with a psychotic illness: The
second Australian survey of psychosis. Australian and
New Zealand Journal of Psychiatry 46(9), 851–863.
Couper, J., Pollard, A.C., Clifton, D.A., 2012.
Depression and Cancer. MJA Open 1(Suppl 4),
13–16.
Curran, E.M., Loi, S., 2012. Depression
and dementia. MJA Open 1(S4), 40–44.
Dolan, M.C., Castle, D.J., McGregor, K., 2012.
Criminally violent victimisation in schizophrenia
spectrum disorders: the relationship to symptoms
andВ substance abuse. BMC Public Health 12(1), 445.
Dowsey, M.M., Dieppe, P., Lohmander, S.,
Castle, D.J., Liew, D., Choong, P.F.M., 2012.
TheВ association between radiographic severity
andВ pre-operative function in patients undergoing
primary knee replacement for osteoarthritis.
The Knee 19(6), 860–865.
Galletly, C.A., Foley, D.L., Waterreus, A., Watts,В G.F.,
Castle, D.J., McGrath, J.J., Mackinnon, A.,
Morgan,В V.A., 2012. Cardiometabolic risk factors
in people with psychotic disorders: The second
Australian national survey of psychosis. Australian
and New Zealand Journal of Psychiatry 46(8),
753–761.
Gilbert, M.M., Chamberlain, J.A., White, C.R.,
Mayers, P.W., Pawsey, B., Liew, D., Musgrave, M.,
Crawford, K., Castle, D.J., 2012. Controlled clinical
trial of a self-management program for people with
mental illness in an adult mental health service–the
Optimal Health Program (OHP). Australian Health
Review 36(1), 1–7.
Gleason, A., Castle, D.J., 2012. Adult attentiondeficit hyperactivity disorder and bipolar disorder.
Advances in Psychiatric Treatment 18(3), 198–204.
Hudson, P., Remedios, C., Zordan, R., Thomas,В K.,
Clifton, D., Crewdson, M., Hall, C., Trauer, T.,
Bolleter, A., Clarke, D.M., 2012. Guidelines for
theВ Psychosocial and Bereavement Support
ofВ Family Caregivers of Palliative Care Patients.
Journal of Palliative Medicine 15(6), 696–702.
Hudson, P.L., Lobb, E.A., Thomas, K., Zordan,В R.D.,
Trauer, T., Quinn, K., Williams, A., Summers, M.,
2012. Psycho-Educational Group Intervention for
Family Caregivers of Hospitalized Palliative Care
Patients: Pilot Study. Journal of Palliative Medicine
15(3), 277–281.
Hudson, P.L., Trauer, T., Lobb, E., Zordan, R.,
Williams, A., Quinn, K., Summers, M., Thomas, K.,
2012. Supporting family caregivers of hospitalised
palliative care patients: a psychoeducational group
intervention. BMJ Supportive & Palliative Care 2(2),
115–120.
Jones, N.C., Reddy, M., Anderson, P., Salzberg,
M.R., O’Brien, T.J., Pinault, D., 2012. Acute
administration of typical and atypical antipsychotics
reduces EEG gamma power, but only the preclinical
compound LY379268 reduces the ketamine-induced
rise in gamma power. The International Journal
of Neuropsychopharmacology 15(5), 657–668.
Joubert, L., Petrakis, M., Cementon, E., 2012.
Suicide Attempt Presentations at the Emergency
Department: Outcomes From a Pilot Study
Examining Precipitating Factors in Deliberate
Self-Harm and Issues in Primary Care Physician
Management. Social Work in Health Care 51(1),
66–76.
Knoesen, N.P., Mancuso, S.G., Thomas, S.,
Komesaroff, P., Lewis, S., Castle, D.J., 2012.
Relationship between severity of obesity and
mentalВ health: An Australian community survey.
Asia-Pacific Psychiatry 4(1), 67–75.
Lee, S.J., Bosanac, P., Hollander, Y., CastleВ D.J.,
Foley, F., Hannagan, E., Kulkarni, J., 2012.
Determining the efficacy and tolerance of quetiapine
extended release for the management of psychosis
and accompanying acute behavioural disturbance
inВ adult acute psychiatry. Annals of Clinical
Psychiatry 24(4), 271–278.
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Ma, N., Liu, J., Wang, X., Gan, Y.-W., Ma, H.,
Ng,В C.H., Jia, F.-J., Yu, X., 2012. Treatment
dropoutВ of patients in National Continuing
Management and Intervention Program for
Psychoses in Guangdong Province from 2006
toВ 2009: Implication for mental health service
reformВ in China. Asia-Pacific Psychiatry 4(3),
181–188.
McGregor, K., Castle, D.J., Dolan, M., 2012.
Schizophrenia spectrum disorders, substance
misuse, and the four-facet model of psychopathy:
The relationship to violence. Schizophrenia Research
136(1–3), 116–121.
Monshat, K., Bosanac, P., Khorsen, G., Gaynor, N.,
Nittoli, S., Castle, D.J., 2012. Are psychiatric Crisis
Assessment and Treatment team clinicians on the
psychotherapy front line? Australasian Psychiatry
20(1), 40–43.
Monshat, K., Castle, D.J., 2012. Mindfulness
training: an adjunctive role in the management
ofВ chronic illness? The Medical Journal of Australia
196(9), 569–564.
Monshat, K., Vella-Brodrick, D., Burns, J.,
Herrman,В H., 2012. Mental health promotion
inВ theВ Internet age: a consultation with Australian
young people to inform the design of an online
mindfulness training programme. Health promotion
international 27(2), 177–186.
Moore, E., Mancuso, S.G., Slade, T., Galletly,В C.,
Castle, D.J., 2012. The impact of alcohol
andВ illicit drugs on people with psychosis:
TheВ second Australian national survey of
psychosis.В AustralianВ andВ New Zealand Journal
of Psychiatry 46(9), 864–878.
Moore, G., Hepworth, G., Weiland, T.,
Manias,В E., Gerdtz, M.F., Kelaher, M., Dunt,В D.,
2012.В ProspectiveВ validation of a predictive
model that identifies homeless people at risk
ofВ re-presentation to the emergency department.
Australasian Emergency Nursing Journal 15(1), 2–13.
Morgan, V.A., Waterreus, A., Jablensky, A.,
Mackinnon, A., McGrath, J.J., Carr, V., Bush, R.,
Castle, D.J., Cohen, M., Harvey, C., Galletly, C.,
Stain, H.J., Neil, A.L., McGorry, P., Hocking, B.,
Shah, S., Saw, S., 2012. People living with psychotic
illness in 2010: The second Australian national
survey of psychosis. Australian and New Zealand
Journal of Psychiatry 46(8), 735–752.
Ng, C.H., Smith, D.J., King, J., Ong, S.,
Schweitzer,В I., 2012. Medication attitudes
andВ beliefsВ in patients with psychotic and
affectiveВ disorders on maintenance treatment.
HumanВ Psychopharmacology: Clinical and
Experimental 27(1), 57–62.
Petrakis, M., Penno, S., Oxley, J., Bloom, H.,
Castle, D.J., 2012. Early psychosis treatment
inВ anВ integrated model within an adult mental
health service. European Psychiatry 27(7), 483–488.
Petrakis, M., Wilson, M., Hamilton, B., 2012.
Implementing the Strengths Model of Case
Management: Group Supervision Fidelity
Outcomes. Community mental health journal, 1–7.
Sankaranarayanan, A., Castle, D.J., 2012.
Monitoring and managing metabolic syndrome
inВ persons with mental illness: the case for. Andhra
Pradesh Journal of Psychological Medicine 13, 9–13.
Shawyer, F., Farhall, J., Mackinnon, A., Trauer,В T.,
Sims, E., Ratcliff, K., Larner, C., Thomas, N.,
Castle,В D.J., Mullen, P., Copolov, D., 2012.
AВ randomised controlled trial of acceptancebased cognitive behavioural therapy for command
hallucinations in psychotic disorders. Behaviour
Research and Therapy 50(2), 110–121.
Ski, C.F., Page, K., Thompson, D.R., Cummins,
R.A., Salzberg, M.R, Worrall-Carter, L., 2012.
Clinical outcomes associated with screening
andВ referral for depression in an acute cardiac ward.
Journal of Clinical Nursing 21(15–16), 2228–2234.
Tang, M.H., Pan, D.J.W., Castle, D.J., Choong,
P.F.M., 2012. A Systematic Review of the Recent
Quality of Life Studies in Adult Extremity Sarcoma
Survivors. Sarcoma 2012.
Tran, N., Castle, D.J., 2012. Outcomes from
aВ regular medication information programme
forВ consumers with a mental illness. Australasian
Psychiatry 20(2), 143–147.
Trauer, J.M., Gielen, C., Trauer, T., Steinfort,
C.L., 2012. Inability of single resting arterial blood
gas toВ predict significant hypoxaemia in chronic
obstructive pulmonary disease. Internal Medicine
Journal 42(4), 387–394.
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Trauer, T., 2012. Palliative models of care for later
stages of mental disorder: Maximising recovery,
maintaining hope and building morale. Australian and
New Zealand Journal of Psychiatry 46(2), 170–172.
Trauer, T., Nagel, T., 2012. Outcome Measurement
in Adult Indigenous Mental Health Consumers.
Advances in Mental Health 11(1), 106–116.
Key, J., Owens, C., Wilson, M. & Petrakis, M.
(2012). Evaluation of a 4 week Rehabilitation
Assessment program at St Vincent’s Mental Health
Community Care Units: mental health consumers
and clinicians perspective, �Recovering Citizenship’,
22nd Annual TheMHS (The Mental health Services)
Conference, Cairns, Queensland, 21–24 August
Waghorn, G., Saha, S., Harvey, C., Morgan, V.A.,
Waterreus, A., Bush, R., Castle, D.J., Galletly,
C., Stain, H.J., Neil, A.L., 2012. �Earning and
learning’in those with psychotic disorders: The
second Australian national survey of psychosis.
Australian and New Zealand Journal of Psychiatry
46(8), 774–785.
Lewis, J., Brophy, L., Petrakis, M., Halloran, K.,
Cocks, N., Buckley, L., Scott, M. & Stylianou, M.
(2012). An evaluation of the recovery orientation
of the Inner Urban East Adult Mental Health
Initiatives – a partnership between Mind Australia
and St Vincent’s Mental Health Service, Refocus
onВ Recovery Conference, Kings College, London,
5–7 March
Waterreus, A., Morgan, V.A., Castle, D.J.,
Galletly,В C., Jablensky, A., Di Prinzio, P., Shah,В S.,
2012. Medication for psychosis–consumption
andВ consequences: The second Australian national
survey of psychosis. Australian and New Zealand
Journal of Psychiatry 46(8), 762–773.
Penno, S., Hamilton, B., Petrakis, M. (2012)
FiveВ year outcomes from an integrated adult early
psychosis program in Australia, International Early
Psychosis Association Conference, San Francisco,
USA, 11–13 October
Weerasundera, R., Castle, D.J., 2012. Extendedrelease quetiapine fumarate in the treatment of
bipolar disorder: a review. Neuropsychiatry 2(5), 1–7.
Worrall-Carter, L., Ski, C.F., Thompson, D.R.,
Davidson, P.M., Cameron, J., Castle, D.J.,
Page,В K.,В 2012. Recognition and referral of
depression in patients with heart disease.
EuropeanВ Journal ofВ Cardiovascular Nursing
11(2), 231–238.
Conference publications
Goding M, Ryan B, White K, Agustin C, Ng C.
Promoting citizenship for people living with mental
illness in the Asia Pacific: Asia Australia Mental
Health. 22nd Annual TheMHS Conference 2012,
Cairns – A/Prof Chee Ng
Hunt, T., Petrakis M. & Bowditch, B. (2012).
Psychiatric triage use by repeat contact
consumers: an evaluation of frequency and
severity of presentations and discharge outcomes,
�Recovering Citizenship’, 22nd Annual TheMHS
Conference, Cairns, Queensland, 21–24 August
Penno, S., Laxton, S., Petrakis, M. (2012)
Intervening early with families dur8ing first
episodeВ psychosis: An evaluation of mental
healthВ nursing psychoeducation within the
inpatientВ unit, International Early Psychosis
Association Conference, San Francisco, USA,
11–13 October
Petrakis, M., Brophy, L., Stylianou, M.,
Scott,В M.,В Lewis, J., Cocks N., Buckley,
L. &В Halloran, K. (2012). Are we recovery
orientated?В Learning from people with lived
experience, �Recovering Citizenship’, 22nd
AnnualВ TheMHS (The Mental Health Services)
Conference, Cairns, Queensland, 21–24 August
Petrakis, M., Hamilton, B. & Wilson, M. (2012).
Strengths model brainstorming: Getting clinicians
on board with consumer and recovery orientated
conversations, Refocus on Recovery Conference,
Kings College, London, 5–7 March
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Speaking engagements
Invited speaker, Dermatology Grand Rounds,
St Vincent’s Hospital, Vic (3.02) Presentation:
�Body Dysmorphic Disorder: Ugliness is only
skin deep’ – Prof David Castle
Invited debater, Royal Melbourne Hospital
MentalВ Health Forum, Melbourne (20.02);
Debate: �Early intervention in psychosis
is not justified’ – Prof David Castle
Invited speaker, AUPOA Annual Symposium,
Challenges in current thinking about mental
disorders in the elderly, Melbourne, Vic (24.02)
Presentations: �Will there be less work for future
oldВ age psychiatrists if early psychosis interventions
actually work?’ – Prof David Castle
Invited keynote speaker, Rotary Mental
Health Forum, Beaumaris, Melbourne (21.03);
Presentation: Body image and teen mental health’
– Prof David Castle
Invited speaker, Centre for Remote Health,
Alice Springs, NT (26–27.03); Presentations:
�Psychiatric aspects of marijuana’; �Optimising
schizophrenia outcomes’ – Prof David Castle
Invited speaker, Broadmeadows Mental Health
Service, Melbourne (4.04); Presentation: �Optimising
schizophrenia outcomes’ – Prof David Castle
Delegate, Third Biennial Schizophrenia Research
Society Conference, Florence, It (14–18.04); Poster
presentations: �Smoking and other cardiovascular
disease risk behaviours among people with severe
mental disorders’; �IV droperidol or olanzapine
asВ adjuncts to midazolam for the acutely agitated
patient: a multi-centre, randomised, double-blind,
placebo-controlled, clinical trial’ – Prof David Castle
Invited speaker, Australian Psychiatrist Expert
Group Conference, Werribee, Vic (20–22.04);
Presentation: �BDD: a disorder in search of
a nosological home’ – Prof David Castle
Invited speaker, University of Melbourne Dental
School, Melbourne, Vic (14.05); Presentation:
�The tooth and the psyche’ – Prof David Castle
Speaker, Royal ANZ College of Psychiatrists
Annual Conference, Hobart, Tas (20–23.05);
Presentation: �Depression with anxiety, anxiety
and depression, anxious depression? A role
for agomelatine?’ – Prof David Castle
Invited speaker, PsyAcademy Asia Faculty Meeting,
Bangkok, Thailand (25–26.05); Presentation: �Recent
evidence in the understanding of schizophrenia
trajectory and implications for clinical practice’
– Prof David Castle
Invited speaker, Fremantle Hospital Mental Health
Forum, Fremantle, WA (22.06); Presentation:
�Improving outcomes in schizophrenia’
– ProfDavid Castle
Invited speaker, Royal College of Psychiatrists
(UK) Annual Congress, Liverpool, UK (12.07);
Presentation: �Improving outcomes in schizophrenia:
learnings from Australia’ – Prof David Castle
Invited speaker, Clinical Controversies Annual
Conference, Melbourne, Vic (29.07); Presentation:
�Early intervention in psychosis: not enough,
not early enough’ – Prof David Castle
Invited speaker, Eastern Health Mental Health
Forum, Melbourne, Vic (21.08); Presentation:
�Promoting good outcomes in schizophrenia’
– Prof David Castle
Invited speaker, Victoria Clinic, Melbourne,
Vic (22.08); Presentation: �Bipolar mixed states’
– Prof David Castle
Invited speaker tour, Singapore (including
InstituteВ of Mental Health, Singapore General
Hospital, National University Hospital),
Singapore (27–28.08); Presentations: �Detecting
non-adherence and shared decision-making: two
steps towards long-term remission in schizophrenia’
– Prof David Castle
Invited speaker tour, Hong Kong and Macau
(including Kwai Chung Hospital, Princess Mary
Hospital), Hong Kong and Macau (29–31.08);
Presentations: �Enhancing treatment outcomes
in schizophrenia’ and �The role of case management
in relapse prevention’ – Prof David Castle
Invited speaker, Victorian Association of Cardiac
Rehabilitation Conference, Melb, Vic (18.10);
Presentation: �Cardiovascular disease in people
with severe mental illness’ – Prof David Castle
Invited speaker, South Australian Psychiatrists
Annual Conference, Barossa, SA (26–27.10);
Presentation: �Early intervention: Is early too early
or not early enough?’ – Prof David Castle
st vincent’s research report 2012
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Mental Health
Invited speaker, Dialogues in Depression
Conference, Sydney, NSW (3–4.11); Presentation:
�Depression with anxiety, anxious depression,
generalised anxiety with depression, or what?’
– Prof David Castle
Petrakis, M. & Doidge G. (2012). Early Psychosis
Program Implementation and Evaluation, Exceptional
Care – Research Excellence. Health Quality Awards,
St Vincent’s Health Australia, Sofiel on Collins,
Melbourne, 23 May.
Invited speaker, South Australian Psychiatrists
Annual Conference, Barossa, SA (26–27.10);
Presentation: �Early intervention: Is early too early
or not early enough?’ – Prof David Castle
Petrakis, M. & Doidge, G. (2012). Early Psychosis
Program Implementation and Evaluation, Exceptional
Care – Research Excellence. Health Quality Awards
Roadshow, St Vincent’s Health Australia, Brisbane,
22 June.
Invited speaker: Assessment and management
ofВ suicidal patients, The Melbourne Clinic 2012
– A/Prof Peter Bosanac
Invited speaker and panellist for 14th World
Congress of Psycho-Oncology/39th Annual
Scientific Meeting of Clinical Oncological Society
of Australia, �A Randomised Controlled Trial of
Cognitive Existential Couple Therapy for early stage
prostate cancer patients and their partners: use
of a manualised therapy in a cancer affecting older
men’ in symposium titled: �Well-being of older cancer
patients: Identification of specific characteristics,
care needs and interventions’, Brisbane, 13
November 2012 – Dr Jeremy Couper
Invited plenary speaker and panellist for Australian
Prostate Cancer Conference, �Exploring the impact
of prostate cancer on the partner’, Melbourne,
3 August 2012 – Dr Jeremy Couper
Invited presenter for Psycho-oncology Network,
Mental Health Professionals Network (MHPN),
Melbourne, 28 June 2012 – Dr Jeremy Couper
Laxton, S. & Petrakis, M. (2012) Intervening early with
families dur8ing first episode psychosis: An evaluation
of mental health nursing psychoeducation within the
inpatient unit, Research Week, St Vincent’s Hospital,
Melbourne, 20–22 August.
Brophy, L., Petrakis, M., Anderson, J., Callander,
R., Cocks, N., Lewis, J., Weavell, W., Zimmermann,
A. (2012), . Research into Recovery: what we are
learning? Panel presentation, Psychiatric Disability
Services of Victoria (VICSERV) Conference
�Reframing Mental Health: a new state of mind’,
TheВ Melbourne Convention and Exhibition Centre,
24–25 May.
Petrakis, M. & Doidge, G. (2012). Early Psychosis
Program Implementation and Evaluation, Exceptional
Care – Research Excellence. Health Quality Awards
Roadshow, St Vincent’s Health Australia, Sydney,
25В June.
Petrakis, M. & Doidge, G. (2012). Early
PsychosisВ Program Implementation and Evaluation,
Exceptional Care – Research Excellent. Health
Quality Awards Roadshow, St Vincent’s Health
Australia, BrenanВ Hall, Melbourne, 26 June.
Petrakis, M. (2012). Taking an idea to an
outcome: the research journey of a mental health
project, HigherВ Degrees by Research Conference,
Department of Social Work, Monash University,
Caulfield, 6–7 February.
Invited speaker: �Acute Psychiatric Forum’,
SVMH, Melbourne, 4.12.2012 – Ms Nga Tran
Invited speaker: Medication Information Forum,
NEAMI, Richmond, 13.11.2012 – Ms Nga Tran
Invited speaker, Medication Information Forum
for Vietnamese consumers and carers, SMHOW,
Brunswick, 2.10.2012 – Ms Nga Tran
Presenter: �Paliperidone LAI – Clinical Experience
@ SVMH’, Melbourne, 4.9.2012 – Ms Nga Tran
Invited speaker, �Clozapine management
and monitor: What’s New?’ SVMH,
Melbourne, 24.7.2012 – Ms Nga Tran
Co-facilitator, �Psychiatric Medications & side
effects’, SVMH Family & Carer Forum, Fitzroy,
23.7.2012 – Ms Nga Tran
st vincent’s research report 2012
119
Mental Health
Invited speaker, Psychiatric medication for
Vietnamese consumers and carers, Western Region
Health Centre, Footscray, 18.7.2012 –Ms Nga Tran
Invited speaker, Psychopharmacology Workshop for
Dianella Community MH clinicians, Broadmeadows,
25.6.2012 – Ms Nga Tran
Invited speaker: �Smoking cessation and psychotropic
medications for Vietnamese consumers & carers’,
St Mary House of Welcome (SMHOW), Brunswick,
5.6.2012 – Ms Nga Tran
Invited speaker: Psychopharmacology workshop for
MHPOD Graduate Allied Health staff, NEVIL Training
Cluster, Melbourne, 24.5.201 .– Ms Nga Tran
Invited speaker: Nicotine Replacement Therapy
for MH – QUIT participants, Mental Illness Fellowship
Victoria, East Melbourne, 8.5.2012 – Ms Nga Tran
Invited speaker: �LAI – Case Study Discussions’,
SVMH, Melbourne, 18.4.2012 – Ms Nga Tran
Invited speaker: �Overview of SVMH – Pharmacy
services for MH Registrars’. SVMH, Melbourne,
10.2.2012 & 17.2.2012 – Ms Nga Tran
Invited speaker: �Medication information program
at SVMH’. La Trobe Mental Health, SVMH,
Melbourne, 31.1.2012 – Ms Nga Tran
Invited speaker: �Clinical experience on the
use of Invega sustenna at SVH’. Janssen-cilag,
Melbourne, 31.1.201 – Ms Nga Tran
Invited speaker: �Clinical experience on the use
of Invega sustenna & PEARL’. SVMH, Melbourne,
13.1.2012 – Ms Nga Tran
Invited speaker: �Overview of Invega sustenna
and PEARL’. Janssen-cilag, Hawthorn CMHS,
Melbourne, 22.12.2012 – Ms Nga Tran
st vincent’s research report 2012
120
Nephrology
Collectively, the staff of the St Vincent’s
Hospital Nephrology Department undertake
aВ diverse range of research activities by virtue
of the collaborative research partnerships
established within the Health service, reflective
of the complex nature of problems based
by patients with kidney disease. Research
activities include the development of new
treatments for kidney disease, disease biomarker
discovery, improvements in dialysis therapies,
mental health issues in kidney disease, as
well as the immunology and complications
ofВ transplantation.
About us
Clinical research projects currently underway
include a study aimed at understanding the high
rate of cardiovascular disease in dialysis patients,
a trial investigating diabetes complications of
transplantation, studies aimed at improving the
knowledge and treatment of depression and
anxiety in patients with kidney disease, and a study
aimed at optimising screening tests for dialysis &
transplant patients to detect previous tuberculosis.
The Department is also involved in several multisite national trials of dialysis care and treatments,
including PEXIVAS, balANZ, Honey Pot, SHARPer
and have a continued participation in an international
practice outcome study (DOPPS). More recently,
theВ team has been involved in studying the effects
ofВ new therapies for diabetic kidney disease.
The Nephrology Unit is also part of a joint
research program with the University of Melbourne
Department of Medicine studying new treatments
aimed at preventing progressive kidney and heart
disease. A number of our team are also part of
theВ Immunology Research Group working in the
areas of xeno-transplantation, Acute Kidney Injury
and glomerulonephritis.
Major projects
The Nephrology team has been part of a number
ofВ new developments in the immunology and
dialysis arena. The first Australian Hand transplant
performed at St Vincent’s Hospital relied heavily
onВ the input and management of the transplant
team, led by DrВ Karen Dwyer. Our Haemodialysis
team welcomedВ the first year anniversary of the
first In-Centre Nocturnal Haemodialysis Program
in Victoria, which has resulted in a number of
improvements in patient outcomes. The Nephrology
Department continues to lead the High-Cut-off
dialysis membrane Program for the treatment
ofВ Acute Kidney Injury from Multiple Myeloma.
The Unit also celebrated 50 years of dialysis at
St Vincent’s, with a gathering of past and present
staff at a Symposium celebrating the Unit’s clinical
and research achievements.
Quality
The Nephrology unit has developed a number
ofВ collaborative clinical programs in Transplantation.
Incorporating transplant surgeons, nephrologists,
transplant coordinators in knowledge sharing,
theseВ programs include the Victorian Renal
Transplant Collaborative, Hand transplantation,
andВ the Islet Cell transplant program for patients
withВ Type 1 diabetes.
St. Vincent’s Hospital Nephrology Unit have also
been leading a clinical program of a new treatment
for Acute Kidney Injury secondary to myeloma cast
nephropathy using extended hours High Cut-off
(HCO) dialysis membranes. In the last 3 years of
the program, a total of 24 patients of the 30 treated
have recovered renal function. This represents a
dramatic improvement from historical outcomes.
st vincent’s research report 2012
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Nephrology
Staff
A/Prof Robyn Langham, Nephrologist 1.0EFT
Dr Karen Dwyer, Nephrologist/Immunologist 1.0EFT
A/Prof David Goodman, Nephrologist/Immunologist
0.5EFT
Dr Hilton Gock, Nephrologist/General Physician
1.0EFT
Dr Mark Lanteri 0.2 EFT
• Dr Hilton Gock is a member of the Australian
and New Zealand Society of Nephrology Council
and involved in a range of national and local
educational programs.
• Our team are active in education initiatives within
the wider community, predominantly as part of
ourВ rural outreach services. Physicians and Nurses
who travel to rural and regional Victoria to treat
patients also offer educational services to medical,
nursing staff and the community asВ aВ whole.
Dr Petrova Lee 0.2 EFT
Ms Margaret Morris Nurse Practitioner 1.0EFT
Collaborations in research
Ms Melissa Stanley 0.6EFT
International
Ms Kim Mullins, Trial & Transplant coordinator
0.4EFT
• Dept Rheumatology, Royal Free Hospital, London,
UK – Anti-fibrotic therapies for scleroderma
Mr Emmet O’Flaherty, Vascular Access Coordinator/
Pre-dialysis educator 1.0EFT
• University of Michigan, Ann Arbour, USA
– Array analysis of molecular pathways
ofВ progressive renal disease
Ms Nuala Barker, Dialysis Manager 1.0EFT
National
Students
• Australian Kidney Trials Network
Dr Veen Roberts PhD
Local
Service to the wider community
• St Vincent’s Hospital Nephrology staff are active
inВ a range of community service activities.
• A/Prof Robyn Langham, as chair of the Victorian
Dept of Health Renal Health Clinical Network
in 2011, led a number of statewide clinical
improvement initiatives, including CKD programs,
the conservative care project and the development
of a number of Key Performance Indicators
forВ theВ Victorian renal community. As Secretary
ofВ theВ Asia Pacific Society of Nephrology, these
initiatives are also being implemented on a
regional scale. She is also active in working with
Kidney Health Australia developing National
guideline statements on eGFR measurements
and proteinuria detection, as well as primary
careВ education programs (KCAT). A/Prof Langham
is also a Board member of AMA Victoria and
theВ Federal Council of the AMA.
• Mental Health Research Institute, University
of Melbourne – Optimal Health Programs
inВ preventing affective disorders in ESKD
• Swinburne University – Antecedents of stress
andВ depression in CKD
• Melbourne Renal units / Peter MacCallum Hospital
– Extended hours HCO dialysis for myeloma
castВ nephropathy.
St Vincent’s Collaborations
• Endocrinology – New Onset Diabetes
AfterВ Transplantation, Islet Cell Transplants
• Infectious Diseases – Incidence of latent
Tuberculosis in ESKD
• Hand Surgery – Vascularised Tissue Allografts
(Hand transplant)
• Rheumatology – Anti-fibrotic therapeis
forВ scleroderma
• Cardiology – Effect of dialysis schedule
onВ Echocardiographic parameters in ESKD
st vincent’s research report 2012
122
Nephrology
Publications
Journal articles
Johnson DW, Brown FG, Clarke M, Boudville
N, EliasВ TJ, Yin MFW, Jones B, Kulkarni H,
LanghamВ RG, Ranganathan D, SchollumВ J,
SuranyiВ M, Tan SH, Voss D. Effects of
BiocompatibleВ versus standard fluid on
peritonealВ dialysis outcomes. J Am Soc
Neph 2012 Jun;23(6):1097–1107.
Johnson DW, Jones G, Doogue M, Jose M,
Langham RG, Lawton P, Ludlow M, MathewВ T,
McTaggart S, Peake M, Polkinghorne K,
UsherwoodВ T. Chronic kidney disease and
automaticВ reporting of estimated glomerular
filtration rate: New developments and revised
recommendations. Med J Australia, 2012
197(4):224–5.
Johnson DW, Brown FG, Clarke M, Boudville N,
Elias TJ, Foo MW, Jones B, Kulkarni H, LanghamВ R,
Ranganathan D, Schollum J, Suranyi MG, Tan SH,
Voss D. The Effects of Biocompatible Compared
with Standard Peritoneal Dialysis Solutions
on Peritonitis Microbiology, Treatment,В and
Outcomes:В the balANZ Trial. Perit Dial Int. 2012
Sep;32(5):497–506.
Johnson DW, Brown FG, Clarke M, Boudville N,
Elias TJ, Foo MW, Jones B, Kulkarni H, LanghamВ R,
Ranganathan D, Schollum J, Suranyi MG, Tan SH,
Voss D. The effect of low glucose degradation
product, neutral pH versus standard peritoneal
dialysis solutions on peritoneal membrane function:
the balANZ trial. Nephrol Dial Transplant. 2012
Dec;27(12):4445–53.
Lekawanvijit S, Kompa AR, Manabe M, Wang
BH, Langham RG, Nishijima F, Kelly DJ, Krum H.
Chronic Kidney Disease-Induced Cardiac Fibrosis
Is Ameliorated by Reducing Circulating Levels of a
Non-Dialysable Uremic Toxin, Indoxyl Sulfate. PLoS
ONE 2012;7(7):e41281.
Gilbert RE, Zhang Y, Williams SJ, Zammit SC,
Stapleton DI, Cox AJ, Krum H, Langham R, Kelly DJ.
A purpose-synthesised anti-fibrotic agent attenuates
experimental kidney diseases in the rat. PLoS One.
2012;7(10):e47160.
Langham RG and Kelly DJ. Urotensin 2 and the
Kidney. Curr Opin Neph Hypertension 2012 in press.
st vincent’s research report 2012
123
Neurosciences
The Centre for Clinical Neurosciences at St
Vincent’s Hospital Melbourne sustains a large
research focus principally centred on epilepsy,
multiple sclerosis, Parkinson’s disease, spinal
cord regeneration, peripheral nerve regeneration,
neuromuscular disorders and mitochondrial
disorders.
The Neurosurgery Department is focussed on
clinical research through the application and
testing of emerging neurosurgical techniques
based upon basic neuroscience principles and
experimental models.
About us
St Vincent’s Centre for Clinical Neuroscience and
Neurological Research (CCNNR) is a multidisciplinary
clinical centre dedicated to improving the
understanding and treatment of neurological
disorders. Our strong research focus is principally
centred on epilepsy, multiple sclerosis, motor
neurone disease and movement disorders and our
department fosters close links and collaborations
with leading institutions both nationally and
internationally.
The Centre for Clinical Neuroscience provides
a complete clinical and diagnostic service and,
through country satellite neurology clinics, we
provide a full range of services to regional Victoria
and host sub-specialty clinics in muscle disease,
epilepsy and movement disorders.
Epilepsy has become a major component of our
clinical service. In 1994 we introduced epilepsy
surgery and in 1998 launched the Victorian Epilepsy
Centre in partnership with the Epilepsy Foundation
and the Alfred Hospital.
Today, St Vincent’s has the largest surgical program
in Australia for epilepsy patients. Our work with
patients and families is supported by a commitment
to both clinical and basic scientific research in
epilepsy. The establishment of an imaging laboratory
has opened new pathways for us. Using techniques
such as co-registration, functional neurosurgery has
become a major focus and has been developed
through a close alliance with the Neurosurgical
Department.
Major projects
EEG Source Localisation – The use of EEG
Source Localisation for the analysis of spike
wave propagation in Hypothalamic Hamartoma
in 32В patients. This is the largest series studied.
The project commenced January 2012 and is
dueВ toВ beВ completed in 2014.
Brain Radio – we have been successful in an
internationally competitive application process
forВ state of the art brain stimulation and recording
devices through Medtronic Inc., and are engaged
in a collaborative study with the Minnesota based
company to study our ability to predict the effects
ofВ medications and electrical stimulation on seizures.
We are performing this in collaboration with the
Werribee Veterinary facility.
Neurovista – In 2012 we completed a first-in-man
study of a novel device to predict seizures, as
part ofВ a project with Austin and Royal Melbourne
Hospitals. This has been very successful and results
were analysed and publication prepared in 2012.
Duchenne Muscular Dystrophy – We have
achievedВ cell-based muscle regeneration
efficienciesВ 1000 times better than existing cell
transplant in the mdx mouse model of Duchenne
Muscular Dystrophy. This was achieved using
a �Trojan Horse’ polymer that protects the cells
thatВ are implanted into the muscle and allows
themВ to form new muscle more effectively than
otherВ methods.
Staff
Prof Mark J Cook, Head of Department
A/Prof Michael Murphy, Program Director
Dr Stephen Bowden, Neuropsychologist
Dr Kristian Bulluss, Neurosurgeon
A/Prof Steven J Collins, Neurologist
Dr Wendyl J D’Souza, Neurologist
Dr Karen Fuller, Neurologist
Prof Malcolm Horne, Neurologist
Dr Katya Kotschet, Neurologist
Dr Patrick O’Brien, Neurologist
Dr Mark Paine, Neurologist
Dr Richard Peppard, Neurologist
st vincent’s research report 2012
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Neurosciences
Dr Christopher Plummer, Neurologist
Dr Naotsugu Tsuchiya, Honorary Research Scientist
Dr Leslie Sedal, Neurologist
Dr Ian A Trounce, Research Fellow
Dr Udaya Seneviratne, Honorary Neurologist
Dr David Szmulewicz, Honorary Neurologist
Simon Vogrin, Scientist,
NeuroimagingВ ResearchВ Analyst
Dr Leslie Roberts, Neurologist
Mr Yi Yuen Wang, Neurosurgeon
Dr Michael Tan, Honorary Neurologist
Jana Wray, IBL Student
Dr Valerie Tay, Neurologist
Dr Yiping Zeng, Research Scientist
Rachel Blake, Research Assistant,
(TheВ UniversityВ ofВ Melbourne)
Students
Hugh Buzacott, Honorary Research Scientist
Adriana Cartwright, Neuroimmunology nurse
Tina Chen, Clinical Trials Coordinator
Koren Clark, Clinical Trials Coordinator
Dr Udaya Seneviratne, Ph.D., Department
ofВ Medicine, The University of Melbourne
Dr Michael Tan, Ph.D., Department of Medicine,
TheВ University of Melbourne
Mabel Diep, IBL Student
Andre Peterson, Ph.D., Department of Electrical
Engineering, The University of Melbourne
Dr Dean Freestone, Research Fellow,
(TheВ UniversityВ of Melbourne)
Dr Patrick O’Brien, Department of Electrical
Engineering, The University of Melbourne
Chris Godden, IBL Student
Bill Zhang, PhD, The University of Wollongong
Mirabelle Ho, Honorary Research Assistant
Hugh Buzzacott (BSc Honours),
TheВ UniversityofВ Melbourne
Miriel Ho, Honorary Research Assistant
Assoc Prof Robert Kapsa, Scientist
Stephan Lau, PhD, Department of Medicine,
TheВ University of Melbourne
Magdalena Kita, Research Assistant,
(TheВ UniversityВ of Wollongong)
Kyle Slater, PhD, Department of Electrical
Engineering The University of Melbourne
Alan Lai, Research Fellow (The Bionics Institute)
Stephan Lau, Honorary Research Scientist
Dr Sebastian Banquier, Department of Veterinary
Science, The University of Melbourne
Dr David Liley, Medical Scientist
David Moses, PhD, The University of Melbourne
Lucas Litewka, Medical Scientist
Dr Prof Long, Honorary Research Scientist
Professor Stephen Livesey,
SeniorВ ResearchВ Scientist
Dr Rosetta Marotta, Research Scientist
Theses passed in 2012
Dr Dean Freestone, PhD,
TheВ UniversityВ ofВ Melbourne
Kristian Bulluss, PhD, The University of Melbourne
Dr Tharun Mysore, Research Scientist
Service to the wider community
Sarah Osborn, Senior Medical Scientist
A/Prof Robert Kapsa
Dr Anita Quigley, Research Fellow,
(TheUniversityofВ Wollongong)
• HREC-A; Research Week Committee
Dr Catriona Sinclair, Research Scientist
Dr Jake Sui, Scientist (The University of Melbourne)
Dr Karen Sweerts, Research Assistant
Johanna Stephens, IBL Student
Dr Kathy Traianedes, Senior Research Scientist
• ARC Centre for Electromaterials Science Executive
Committee
• Australian Academy of Science Decadal Plan
forВ Nanomedicine Research Committee
• NHMRC Review Committee for Career
Development Fellowships.
st vincent’s research report 2012
125
Neurosciences
Prof Mark Cook
• Associate Editor, Epilepsia
• Chairman, Animal Ethics Committee, St Vincent’s
• Board Member, St Vincent’s Foundation
• Board Member, O’Brien Institute
• President, Epilepsy Foundation of Victoria
A/Prof Michael Murphy
• Neurosurgical Society of Australasia
BoardВ Member
• Clinical Improvement & Innovation Committee,
St Vincent’s
• Member of Executive Committee of Asian
Australasian Society of Stereotactic and
FunctionalВ Neurosurgery
• Member of Hospital Executive Committee,
St Vincent’s
• Member of Medical Advisory Committee,
St Vincent’s
• Committee Member, Epilepsy Australia
Consultative Panel
• Electoral College Committee, St Vincent’s
• Honorary Clinical Research Fellow,
TheВ BionicsВ Institute, Melbourne
• Research Endowment Fund Committee,
St Vincent’s
• Journal of Clinical Neuroscience – reviewer
• Journal of Acta Neurochirurgica – reviewer
• Journal of Epilepsia – reviewer
Mr Yi Yuen Wang
• Invited Faculty member of International Forum
ofВ Minimally Invasive Surgery, Shanghai
• Invited Faculty member of Minimally invasive
spine surgery, elevating best practice in spine,
Macquarie University, Sydney
Grants
Project Grants
Wendyl D’Souza
Deployment of portable epilepsy research device,
St Vincent’s Hospital Melbourne
$18,000 for 2012
Prof GG Wallace; Dr SE Moulton; Prof MJ Cook
Approved Novel Drug Delivery Systems, ARC
$1,220,000 for 5 years ($300,000 in 2012)
Dr David B Grayden, Prof Anthony N Burkitt,
ProfВ Dragan Nesic, Prof Mark J Cook
Optimisation of signal processing and electrical
stimulation algorithms for the abatement of
epilepticВ seizures, ARC
$265,000 for 4 years ($90,000 in 2012)
Prof Mark Cook, Prof Gordon Wallace,
DrВ SimonMoulton, Assoc Prof Robert Kapsa
Advanced Polymer Systems for the Delivery
of Anti-Epileptic Drugs to the CNS, NHMRC
$514,375 for 3 years ($184,500 in 2012)
Cook M, Grayden D, Johnston L, Plummer C
Non-invasive Methods for Localising Epileptic
BrainВ Activity, NHMRC
$642,350 for 3 years ($287,450 in 2012)
Robert Kapsa (and 12 others)
ARC, Australian Research Council
$19,200,000 for 8 years ($92,500 in 2012)
Kapsa, Wallace, Murphy, Kyratzis
Polymers for Nerve Repair, NH&MRC
$690,000 for 3 years ($230,000 in 2012)
Kapsa, Wallace, Officer, Penington
Polymers for Muscle repair, NHMRC
$570,000 for 3 years ($50,000 in 2012)
Kapsa, R; Wallace, G; Kyratzis, I; Murphy, M
Multimodal woven biopolymer conduits for
remodelling damaged peripheral nerves,
NHMRCВ Research Grant
$662,500 for 2010–2012 ($220,833.33 in 2012)
Clinical Trials
Paine M, Sedal L, Plummer C, Shuey N,
McDonald E, French A, Wilson I
A Phase III, multicentre, randomized, parallel-group,
double blinded, placebo controlled study to evaluate
the efficacy and safety of ocrelizumab in adults with
Primary Progressive Multiple Sclerosis, Roche
$122,804 for 5.5 years ($56,160 in 2012)
st vincent’s research report 2012
126
Neurosciences
Paine M, Sedal L, Plummer C, Shuey N,
McDonald E, French A
An open-label, multicentre, multinational study
toВ assess the effect of long-term prolonged-release
Fampridine (BIIB041) 10mg twice daily on quality
ofВ life as reported by subjects with Multiple Sclerosis,
Biogen Idec.
$120,900 for 1 year ($89,280 in 2012)
Paine M, Sedal L, Plummer C, Shuey N,
McDonald E, French A
An open-label, multicentre, multinational study
toВ assess the effect of long-term prolonged-release
Fampridine (BIIB041) 10mg twice daily on quality
ofВ life as reported by subjects with Multiple Sclerosis,
Biogen Idec.
$120,900 for 1 year ($89,280 in 2012)
Paine M, Sedal L, Plummer C, Shuey N,
McDonald E, French A, Wilson I
An extension protocol for multiple sclerosis patients
who participated in Genzyme sponsored studies
ofВ Alemtuzumab, Genzyme Sanofi
$91,835 for 4 years ($33,000 in 2012)
Paine M, Sedal L, Plummer C, Shuey N,
McDonald E, French A, Wilson I
An extension protocol for multiple sclerosis patients
who participated in Genzyme sponsored studies
ofВ Alemtuzumab, Genzyme Sanofi
$91,835 for 4 years ($33,000 in 2012)
Paine M, Sedal L, Plummer C, Shuey N,
FrenchВ A, Wilson I
A single arm, open-label, multicentre study
evaluating the long-term safety, tolerability
andВ efficacy of 0.5 mg Fingolimod (FTY720)
administered orally once daily in patients with
relapsing forms of multiple sclerosis, Novartis
$136,500 for 5 years ($20,400 in 2012)
Paine M, Sedal L, Plummer C, Shuey N,
FrenchВ A, Wilson I
A single arm, open-label, multicenter study
evaluating the long-term safety, tolerability and
efficacy of 0.5 mg Fingolimod (FTY720) administered
orally once daily in patients with relapsing forms
ofВ multiple sclerosis, Novartis
$136,500 for 5 years ($20,400 in 2012)
Paine M, Sedal L, Plummer C, Shuey N,
FrenchВ A, Wilson I
A Dose-Blind, Multicenter, Extension Study to
Determine the Long-Term Safety and Efficacy of
TwoВ Doses of BG00012 Monotherapy in Subjects
with Relapsing-Remitting Multiple Sclerosis,
BiogenВ Idec.
$40,964 for 5 years ($15,600 in 2012)
Paine M, Sedal L, Plummer C, Shuey N,
FrenchВ A, Wilson I
A Dose-Blind, Multicenter, Extension Study to
Determine the Long-Term Safety and Efficacy
ofВ TwoВ Doses of BG00012 Monotherapy in
SubjectsВ with Relapsing-Remitting Multiple
Sclerosis,В Biogen Idec.
$40,964 for 5 years ($15,600 in 2012)
Paine M, Sedal L, Plummer C, Shuey N,
FrenchВ A, Wilson I
A Multi-Centre Double-Blind Parallel-Group
Placebo-Controlled Study Of The Efficacy
AndВ Safety Of Teriflunomide In Patients With
Relapsing Multiple Sclerosis, Genzyme Sanofi
$18,210 for 3 years ($6,800 in 2012)
Paine M, Sedal L, Plummer C, Shuey N,
FrenchВ A, Wilson I
A Multi-Center Double-Blind Parallel-Group
Placebo-Controlled Study Of The Efficacy
AndВ Safety Of Teriflunomide In Patients With
Relapsing Multiple Sclerosis, Genzyme Sanofi
$18,210 for 3 years ($6,800 in 2012)
Paine M, Sedal L, Plummer C, Shuey N
TYSABRI Observational Program (TOP),
BiogenВ Idec.
$25,500 for 17 years ($4,500 in 2012)
Paine M, Sedal L, Plummer C, Shuey N
TYSABRI Observational Program (TOP),
BiogenВ Idec.
$25,500.00 for 17 years ($4,500 in 2012)
Paine M, Sedal L, Plummer C, Shuey N,
McDonald E, French A, Wilson I
A Phase III, multicentre, randomized, parallel-group,
double blinded, placebo controlled study to evaluate
the efficacy and safety of ocrelizumab in adults with
Primary Progressive Multiple Sclerosis, Roche
$122,804 for 5.5 years ($56,160 in 2012)
Paine M, Sedal L, Plummer C, Shuey N,
FrenchВ A, McDonald E
Phase IIb randomised, double blind, placebocontrolled, dose ranging trial of Vitamin D
inВ patientВ with a first demyelinating event.,
MSВ researchВ Australia (MSRA)
$8232/ patient (study not yet initiated)
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Neurosciences
Paine M, Sedal L
Renew, Merck Serono Australia Pty Ltd
$5,000.00 for 2012
Paine M, Sedal L, Plummer C, Shuey N
MSBasis, The MSBASE foundation Ltd, Australia
$3,960 for 2012
D’Souza W, Cook M, Fuller K, Tan M,
PlummerВ C,Wilson I, Litewka L, Godden C,
Braybrook M, Osborn S.
An open-label extension phase of the double-blind,
placebo-controlled, dose-escalation, parallel-group
studies to evaluate the efficacy and safety of E2007
(perampanel) given as adjunctive therapy in subjects
with refractory partial seizures, EISAI
D’Souza W, Cook M, Fuller K, Tan M,
PlummerВ C,Wilson I, Litewka L, Godden C,
Braybrook M, Osborn S.
A double-blind, randomised, placebo-controlled,
multicentre, parallel-group study with an open label
extension phase to evaluate the efficacy and safety
of adjunctive perampanel in primary generalized
tonic-clonic seizures, EISAI
D’Souza W, Cook M, Fuller K, Tan M,
PlummerВ C,Wilson I, Litewka L, Godden C,
Braybrook M, Osborn S.
Efficacy and safety of Eslicarbazepine Acetate
(BIAВ 2-093) as monotherapy for patients with newly
diagnosed partial-onset seizures: A double-blind,
randomised, active-controlled, parallel-group,
multicenter clinical study, BIAL
D’Souza W, Cook M, Fuller K, Tan M,
PlummerВ C,Wilson I, Litewka L, Godden C,
Braybrook M, Osborn S.
Efficacy and safety of Eslicarbazepine acetate
(BIAВ 2093) as adjunctive therapy for refractory
partialВ seizures in a double blind, randomised,
placebo controlled, parallel group, multicentre
clinical trial, BIAL
D’Souza W, Cook M, Fuller K, Tan M,
PlummerВ C,Wilson I, Litewka L, Godden C,
Braybrook M, Osborn S.
Safety and effectiveness of a seizure advisory
system in epilepsy: A feasibility study (Victoria),
Neurovista
D’Souza W, Cook M, Fuller K, Tan M,
PlummerВ C,Wilson I, Litewka L, Godden C,
Braybrook M, Osborn S.
An open label, multinational, multi centre, follow-up
study to evaluate the long-term safety and efficacy
of brivaracetam, used at a flexible dose up to a
maximum of 150mg/day in subjects aged 16 years
or older suffering from epilepsy, UCB
D’Souza W, Cook M, Fuller K, Tan M,
PlummerВ C,Wilson I, Litewka L, Godden C,
Braybrook M, Osborn S.
A Randomised, Double Blind, Placebo Controlled
Study of the Safety and Efficacy of Intranasal
Midazolam (USL261) in the Outpatient Treatment
ofВ Subjects with Seizure Clusters, USL
D’Souza W, Cook M, Fuller K, Tan M,
PlummerВ C,Wilson I, Litewka L, Godden C,
Braybrook M, Osborn S.
A multi-centre, double-blind, double dummy,
randomized, positive controlled study comparing
theВ efficacy and safety of lacosamide (200 to
600mg/day) to controlled release carbamazepine
(400 to 1200mg/day), used as monotherapy in
subjects newly or recently diagnosed with epilepsy
and experiencing partial onset or generalized tonic
clonic seizures, UCB
D’Souza W, Cook M, Fuller K, Tan M,
PlummerВ C,Wilson I, Litewka L, Godden C,
Braybrook M, Osborn S.
A randomised, multicentre, double-blind, placebocontrolled, parallel-group, phase 3 study to evaluate
the efficacy and safety of USL255 as adjunctive
therapy in patients with refractory partial-onset
seizures, USL
D’Souza W, Cook M, Fuller K, Tan M, Plummer
C,Wilson I, Litewka L, Godden C, Braybrook M,
Osborn S.
A historical-controlled, multicenter, double-blind,
randomized trial to assess the efficacy and safety of
conversion to Lacosamide 400mg/day monotherapy
in subjects with partial-onset seizures, UCB
Kotschet K, Horne M, Litewka L,, Osborn S.
A double-blind, randomised, placebo-controlled
study to investigate the tolerability and the effect
of three multiple-dose regimens of BIA 9-1067
on the levodopa pharmacokinetics, catechol-Omethyltransferase activity and motor response
in Parkinson’s Disease patients treated with
levodopa/dopa-decarboxylase inhibitor, BIAL
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Kotschet K, Osborn S, Litewka L
A phase III, multicentre, double blind, prospective,
randomised, placebo controlled study, assessing
the efficacy and safety of Dysport used for the
treatment of lower limb spasticity in adult subjects
with hemiparesis due to stroke or traumatic brain
injury, IPSEN
• The Bionics Institute
Roberts L, Carne R, Tan M, Kamel J,
LitewkaВ L,В Willems N
Randomised, multicenter, double-blind, placebocontrolled, parallel-group phase III study to
investigate the efficacy, safety, and tolerability
of 2 different doses of IgPro20 (subcutaneous
immunoglobulin) for the treatment of chronic
inflammatory demyelinating polyneuropathy
(CIDP) – the PATH study, CSL Behring
• Deakin University
Roberts L, Carne R, Tan M, Kamel J,
LitewkaВ L,В Willems N, Chen T
A double-blind, randomised, multicenter, placebo
controlled, parallel-group study to evaluate the efficacy
and safety of 0.5 mg fingolimod administered orally
once daily versus placebo in patients with chronic
inflammatory demyelinating polyradiculoneuropathy
(CIDP), Novartis
Wang YY, Zadar Z, Gnanalingham KK. Performing
a trans-sphenoidal approach. E-Brain Learning
Program.
Collins S, Murphy D, Szmulewicz,
LitewkaВ L,В Braybrook M
A randomised, double-blind, placebo-controlled trial
to evaluate the safety, tolerability and the biological
and cognitive effects of VEL015 (sodium selenate)
in patients with mild to moderate Alzheimer’s
Disease – A Pilot Study, Velacor
Collaborations in research
International
• Technical University Ilmenau, Germany
• Friedrich-Schiller-University Jena, Germany
• University of Texas, Dallas USA
• University of California San Francisco
(SanВ Francisco, USA)
National
• RMIT University
• The Florey Institute of Neuroscience
andВ MentalВ Health
• Monash University
• Commonwealth Scientific and Industrial
ResearchВ Organisation (CSIRO)
• Latrobe University
• Swinburne University
Publications
Books
Wallace, G.G., Moulton, S.E., Higgins, M.J.,
andВ Kapsa, R.M.I., (2012); Organic Bionics,
Wiley-VCH (ISBN 978–3–527–32882–6,)
Book chapters
Zadar Z, Wang YY, Gnanalingham KK. Performing
anВ eye-brow craniotomy. E-Brain Learning Program.
Abou-Zeid A, Zadar Z, Wang YY, Gnanalingham KK.
MIS Approaches to the Posterior Thoraco-lumbar
Spine. E-Brain Learning Program.
Journal articles
Alcalde-Cabero E, AlmazГЎn-Isla J, Brandel JP,
Breithaupt M, Catarino J, Collins S, Haybäck J,
Höftberger R, Kahana E, Kovacs GG, Ladogana A,
Mitrova E, Nakamura Y, Pocchiari M, Popovic M,
Ruiz-Tovar M, Taratuto AL, van Duijn C, YamadaВ M,
Zerr I, de Pedro-Cuesta. Health professionsВ and
risk of sporadic Creutzfeldt-Jakob disease.
EuroSurveillance 2012; 17: pii=20144.
Aumann, T. and M. Horne (2012). “Activity-dependent
regulation of the dopamine phenotype in substantia
nigra neurons.” J Neurochem 121(4): 497–515.
Badawy RA, Freestone DR, Lai A, Cook MJ (2012).
Epilepsy: ever-changing states of cortical excitability.
Neuroscience: 222: 89–99
Badawy RA, Macdonell RA, Vogrin SJ, Lai A, Cook
MJ. (2012). Cortical excitability decreases in LennoxGastaut syndrome: 53(9): 1546–53.
• The University of Wollongong
• The University of Melbourne
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Neurosciences
Badawy, R. A., Freestone, D.R., Lai, A., Cook, M.
J. (2012). Epilepsy: Ever-changing states of cortical
excitability. Neuroscience 222C: 89–99.
Badawy, R. A., Johnson, K. A., Cook, M. J.,
Harvey,В A.; (2012). A mechanistic appraisal
of cognitive dysfunction in epilepsy. Neurosci
BiobehavВ Rev. S.
Badawy, R. A., Macdonell, R. A., Vogrin, S.J.,
Lai,В A., Cook, M.J. (2012). Cortical excitability
decreases in Lennox-Gastaut syndrome. Epilepsia.
Bergin P, Sadleir L, Legros B, Mogal Z, TripathiВ M,
Dang N, Beretta S, Zanchi C, Burneo J, BorkowskiВ T,
Je Cho Y, Ossemann M, StrianoВ P, Srivastava K,
Jan Tan H, Wanigasinghe J and D’Souza W, for
theВ EpiNet study group. An international pilot study
of an Internet-based platform to facilitate clinical
research in epilepsy: The EpiNet project Epilepsia.
Article first published online: 7 SEP 2012, DOI:
10.1111/j.1528–1167.2012.03636.x IF 3.961
Chitnis, T., S. Tenembaum, et al. (2012).
ConsensusВ statement: evaluation of new
andВ existing therapeutics for pediatric multiple
sclerosis. Mult Scler 18(1): 116–127.
Clarke, N. F., L. B. Waddell, et al. (2012). Mutations
in TPM2 and congenital fibre type disproportion.
Neuromuscul Disord 22(11): 955–958.
D’Souza WJ, Quinn SJ, Fryer JL, Taylor BV,
Ficker DM, O’Brien TJ, Pearce NE, Cook MJ.
TheВ prevalence and distribution of treated epilepsy:
A community-based study in Tasmania, Australia.
Acta Neurol Scand 2012; 125 (2): 96–104.
(IFВ 2.3,В 2В citations).
Dale, R. C., V. Merheb, et al. (2012). Antibodies
to surface dopamine-2 receptor in autoimmune
movement and psychiatric disorders. Brain
135(Pt 11): 3453–3468.
D’Souza, W. J., Quinn, S. J., Fryer, J.L., Taylor, B.V.,
Ficker, D.M., O’Brien, T.J., Pearce, N., Cook, M.J.
(2012). The prevalence and demographic distribution
of treated epilepsy: a community-based study
inВ Tasmania, Australia. Acta Neurol Scand 125(2):
96–104.
Escolar, D. M., A. Zimmerman, et al. (2012).
Pentoxifylline as a rescue treatment for DMD:
aВ randomized double-blind clinical trial. Neurology
78(12): 904–913.
Farg, M. A., K. Y. Soo, et al. (2012). Mutant FUS
induces endoplasmic reticulum stress in amyotrophic
lateral sclerosis and interacts with protein disulfideisomerase. Neurobiol Aging 33(12): 2855–2868.
Fuller K, Wang Y, Murphy M, Cook M, D’Souza W.
Tolerability of IV levetiracetam vs. IV phenytoin in a
neurosurgical population: a prospective randomised
study. Epilepsia (accepted for publication May 2012)
Frugier, T., A. Conquest, et al. (2012). Expression
and activation of EphA4 in the human brain after
traumatic injury. J Neuropathol Exp Neurol 71(3):
242–250.
Fuller, K. L., Wang, Y. Y., Cook, M.J., Murphy,
M.A., D’Souza, W.J. (2012). Tolerability, safety,
andВ side effects of levetiracetam versus phenytoin
inВ intravenous and total prophylactic regimen among
craniotomy patients: A prospective randomized
study. Epilepsia.
Gilbert, F., Harris, A., and Kapsa, R.M.I., (2012);
Efficacy Testing as a Primary Purpose of Phase
1 Clinical Trials: Is it Applicable to First-in-Human
Bionics and Optogenetics Trials? Am. J. Bioethics
(Neuroscience), (IF=3.9)
Griffiths, R. I., K. Kotschet, et al. (2012). Automated
Assessment of Bradykinesia and Dyskinesia in
Parkinson’s Dise. Journal of Parkinson’s Disease 2:
47–55.
Halliday, A. J., Moulton, S. E., Wallace, G. G.,
Cook, M. J.; (2012). “Novel methods of antiepileptic
drug delivery – Polymer-based implants.” Adv Drug
DelivВ Rev.
Harris, A.R., Morgan, S.J., Chen, J., Kapsa,В R.M.I.,
Wallace, G.G.,3 and Paolini, A.G., (2012); Conducting
polymer coated neural recording electrodes.
JВ Neural Eng, 10(1):016004 [Epub aheadВ of print]
(IF=3.4)
Howell, K. B., K. Tiedemann, et al. (2012).
Symptomatic generalized epilepsy after HHV6
posttransplant acute limbic encephalitis in children.
Epilepsia 53(7): e122–126.
Johanssen VA, Barnham KJ, Masters CL, Hill AF,
Collins SJ. Generating recombinant prion protein
fragments of exact native sequence. Neurochemistry
International 2012; 60: 318–326.
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Kamel, J. T., Degruyter, M. A., D’Souza, W.J.,
Cook, M.J. (2012). Clinical experience with using
lacosamide for the treatment of epilepsy in a tertiary
centre. Acta Neurol Scand.
Karas JA, Boland M, Haigh C, Wall VA, Hill AF,
Barnham K, Collins SJ, Scanlon D. Microwave
synthesis of prion protein fragments up to 111
amino acids in length generates biologically active
peptides. International Journal of Peptide Research
and Therapeutics 2012; 18: 21–29.
Klemm HMJ, Welton JM, Masters CL, Hill AF,
CollinsВ SJ, Lawson VA. Determining the PrPC
conversion dependence of sporadic CreutzfeldtJakob Disease molecular subtypes. The Journal
of Biological Chemistry 2012; 287: 36465–36472.
Klistorner, A., R. Garrick, et al. (2012). Relationship
between chronic demyelination of the optic nerve
and short term axonal loss. J Neurol Neurosurg
Psychiatry 83(3): 311–314.
Klug GM, Boyd A, McGlade A, Stehmann C,
Simpson M, Masters CL, Collins SJ. Surveillance
of Creutzfeldt-Jakob disease in Australia: update
to December 2011. Communicable Diseases
Intelligence 2012; 36: E174–179.
Kolbe, S., C. Bajraszewski, et al. (2012). Diffusion
tensor imaging of the optic radiations after optic
neuritis. Hum Brain Mapp 33(9): 2047–2061.
Lewis V, Klug GMA, Masters CL, Hill AF, Lawson VA,
Collins SJ. Prion subcellular fractionation revelas
infectivity spectrum with a high titre-low PrPSc
disparity. Molecular Neurodegeneration 2012; 7:
18(doi:10.1186/1750–1326–7–18).
Lewis V, Whitehouse IJ, Baybutt H, Manson JC,
Collins SJ, Hooper NM. Prion protein expression
is not regulated by the Alzheimer’s amyloid precursor
protein intracellular domain. PLoS One 2012; 7:
e31754.
Liang, X., L. Kuhlmann, et al. (2012). Extending
Communication for Patients with Disorders of
Consciousness. J Neuroimaging.
McKelvie P, Infeld B, Marotta R, Chin J, Thorburn D,
Collins S. A case of late-adult onset Leigh syndrome
with review of the literature of adult-onset cases.
Journal of Clinical Neuroscience 2012; 19: 195–202.
McKelvie P, Marotta R, Thorburn DR, Chin J,
Punchichewa S, Collins S. A case of myelopathy,
myopathy, peripheral neuropathy and subcortical
grey matter degeneration associated with recessive
compound heterozygous POLG1 mutations.
Neuromuscular Disorders 2012; 22: 401–405.
McKelvie, P., B. Infeld, et al. (2012). Late-adult onset
Leigh syndrome. J Clin Neurosci 19(2): 195–202.
Molino, P.J., Higgins, M.J., Innis, P., Kapsa, R.M.I.,
and Wallace, G.G., (2012); Fibronectin and bovine
serum albumin adsorption and conformational
dynamics on inherently conducting polymers as
resolved by QCM-D. Langmuir 28(22):8433–45.
(IF=4.9)
Morris, M. E., C. Martin, et al. (2012). Protocol for
ahome-based integrated physical therapy program
to reduce falls and improve mobility in people with
Parkinson’s disease. BMC Neurol 12: 54.
Moulton, S.E., Higgins, M., Kapsa, R.M.I.,
Wallace,В G.G., (2012); Organic Bionics: A New
Dimension in Neural Communications, Advanced
Functional Materials, 22:2003–2014. (IF=6.9)
Plummer C, Campagnaro R Flash Pulmonary
Oedema in Multiple Sclerosis. Journal of Emergency
Medicine Sep 16, 2012, ePub 169–172.
Quigley, A.F, Razal, J.M., Kita, M., Jalili, R.,
Penington A.J., Ovalle-Robles, R., Baughman, R.H.,
Clark G.M., Wallace, G.G., and Kapsa, R.M.I. (2012);
Electrical Stimulation of Primary Murine Myoblasts
on Aligned Nanostructured Conductive Polymer
Platforms. Advanced Healthcare Materials 1(6):801–8.
Seneviratne, U., M. Cook, et al. (2012).
TheВ prognosis of idiopathic generalized epilepsy.
Epilepsia 53(12): 2079–2090.
Soo, K. Y., J. D. Atkin, et al. (2012). Bim links
ERВ stress and apoptosis in cells expressing mutant
SOD1 associated with amyotrophic lateral sclerosis.
PLoS One 7(4): e35413.
Sui, Y., M. K. Horne, et al. (2012). Reduced
proliferation in the adult mouse subventricular zone
increases survival of olfactory bulb interneurons.
PLoS One 7(2): e31549.
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Sun-Edelstein C, Mauskop A. (2012).
Complementary and alternative approaches
toВ theВ treatment of tension-type headache.
Curr Pain Headache Rep: 16: 539–44.
Szmulewicz, D. J. and J. A. Waterston (2012).
TwoВ patients with audiovestibular sarcoidosis.
J Clin Neurosci 19(1): 158–161.
Tepper SJ, Shapiro RE, Sun-Edelstein C, Evans RW,
Tietjen GE. (2012) Triptans and serotonin syndromea response. Headache: 52: 1185–8.
Villemagne, V. L., N. Okamura, et al. (2012).
“Differential diagnosis in Alzheimer’s disease and
dementia with Lewy bodies via VMAT2 and amyloid
imaging.” Neurodegener Dis 10(1–4): 161–165.
Wan, J., M. Yourshaw, et al. (2012). “Mutations in
the RNA exosome component gene EXOSC3 cause
pontocerebellar hypoplasia and spinal motor neuron
degeneration.” Nat Genet 44(6): 704–708.
Wang, Y., A. van der Walt, et al. (2012). “Optic nerve
magnetisation transfer ratio after acute optic neuritis
predicts axonal and visual outcomes.” PLoS One
7(12): e52291.
Wang YY, Kearney T, du Plessis D, Gnanalingham
KK. Extraventricular neurocytoma of the sellar
region: Case report. British Journal of Neurosurgery
2012 26(3):420–2.
Wang YY, Higham C, Kearney T, Davis JRE,
Trainer P, Gnanalingham KK. Acromegaly surgery
in Manchester revisited – The impact of reducing
surgeon numbers and the 2010 consensus
guidelines for disease remission. Clinical
Endocrinology (Oxf) 2012 Mar 76(3):399–406
Ware, T. L., M. M. Ryan, et al. (2012). Autoimmune
myasthenia gravis, immunotherapy and thymectomy
in children. Neuromuscul Disord 22(2): 118–121.
Wilkins, E. J., J. P. Rubio, et al. (2012). A DNA
resequencing array for genes involved in Parkinson’s
disease. Parkinsonism Relat Disord 18(4): 386–390.
Yue, Z., Moulton, S. E., Cook, M., O’Leary, S.,
Wallace, G. G.; (2012). Controlled Delivery for
Neuro-Bionic Devices. Adv Drug Deliv Rev.
Conference publications
Michael Murphy
Philip J, Collins A, Brand C, Gold M, LethborgВ C,
Murphy M, Moore G, Bohensky M, and
Sundararajan V. Utilising Hospital Administrative
Datasets to Identify Patterns of Service Use
in Patients with a Primary Malignant Glioma.
International Psycho-Oncology Society’s 14th World
Congress of Psycho-Oncology, Brisbane, 13–15th
November 2012. Asia-Pac J Clin Oncol 2012;
8(S3):189
Philip J, Collins A, Gold M, Brand C, Lethborg C,
Murphy M, Moore G, Sundararajan V, and MooreВ G.
Understanding the Supportive and Palliative Care
needs of People with a Primary Malignant Glioma
and Their Carers. International Psycho-Oncology
Society’s 14th World Congress of Psycho-Oncology,
Brisbane, 13–15th November 2012. Asia-Pac J Clin
Oncol 2012; 8(S3): 189
Collins A, Sundararajan V, Brand C, Gold M,
Bohensky M, Lethborg C, Murphy M, Moore
G, andВ Philip, J. Utilising Hospital Administrative
Datasets to Identify Patterns of Service Use
in Patients with a Primary Malignant Glioma.
19th International Congress of Palliative Care,
Montreal, Canada, 8–12th October 2012.
J Pal Care 2012; 28(3): 189–90
Collins A, Brand C, Gold M, Lethborg C,
MurphyВ M, Moore G, Sundararajan V, and Philip J.
Understanding the Supportive and Palliative Care
Needs of People with Primary Malignant Glioma
andВ Their Carers. 19th International Congress of
Palliative Care, Montreal, Canada, 8–12th October
2012. J Pal Care 2012 28(3): 213–14
Philip, J, Bohensky M, Gemelli C, Brand C, Gold M,
Lethborg C, Murphy M, Moore G, Collins A, and
Sundararajan V. Utilising Hospital Administrative
Datasets to Identify Patterns of Service Use in
Patients with a Primary Malignant Glioma. European
Association of Palliative Care (EAPC), Trondheim,
Norway, 7–9th June 2012. Palliat Med 2012; 26(4): 521
Philip J, Collins A, Lethborg C, Gold M, MurphyВ M,
Moore G, Sundararajan V, and Brand C.
Understanding the Supportive and Palliative Care
Needs of People with Primary Malignant Glioma
andВ Their Carers. European Association of Palliative
Care (EAPC), Trondheim, Norway, 7–9th June 2012.
Palliat Med 2012; 26(4): 521–22
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Speaking engagements
Mark Cook
New strategies in epilepsy therapy, 7th Annual
International Electromaterials Science Symposium,
Geelong, Victoria, Australia, Feb 2012
Drug Resistant Epilepsy: Recognise it, Treat it
– How to treat drug resistant epilepsy, ASEPA Precongress workshop, Manila, Philippines, Mar 2012
The Epilepsy Project, Bill Wheeler Symposium,
Wollongong, New South Wales, Australia, Aug 2012
How to be a leader in your career, Monash
Leadership Seminar, Melbourne, Victoria,
Australia,В Aug 2012
New approaches to epilepsy management; 3rd AsiaPacific Symposium on Nanobionics; Wollongong,
New South Wales, Australia, Sept 2012
The Demon in the Body; A Body of Knowledge
Symposium, The University of Melbourne, Parkville,
Victoria, Australia, Sept 2012
Devices and epilepsy: the future? Seizure prediction
and other novel management strategies; Lectures
at the Interface: The interface between epilepsy
and engineering, 10th European Congress
onВ Epileptology, London, England, Oct 2012
Non-pharmacological Therapy; Improving outcomes
for people with epilepsy: strategies for general
practice; Epilepsy Society of Australia 26th Annual
Scientific Meeting / Etas, Hobart, Tasmania,
Australia, Nov 2012
Alan Lai
Electrical probing and seizure detection (presented
byВ Alan Lai), Epilepsy Society of Australia 26th
Annual Scientific Meeting, Hobart, Australia,
31 October–2 November 2012
Stephan Lau
S. Lau, S. Vogrin, W. D’Souza, J. Haueisen and
M. Cook. ESI-fMRI in focal epilepsy: Differentiation
of interictal activity in high-density EEG. Invited
presentation by S. Lau at the Symposium on Resting
State fMRI in Epilepsy, XuanWu Hospital, Beijing,
China, June 16, 2012.
S. Lau, D. Guellmar, L. Flemming, J. Haueisen.
Skull defects in MEG and EEG: Experimental results
and modelling. Invited presentation by S. Lau at
46th Annual Conference of the German Society
for Biomedical Engineering (DGBMT), Sept 16–19,
Jena, Germany, 2012.
S. Lau, B. Petkovic, L. Di Rienzo, J. Haueisen.
Optimizing a magnetic sensor vest for cardiac
source imaging. Presentation by S. Lau at 46th
Annual Conference of the German Society for
Biomedical Engineering (DGBMT), Sept 16–19,
Jena,В Germany, 2012.
S. Lau, L. Flemming, J. Haueisen. Skull defects
in MEG and EEG: Experimental results in animal
models. Presentation by S. Lau at the 2012 World
Congress on Medical Physics and Biomedical
Engineering, Beijing, China, May 26–31, 2012.
S. Lau, D. Guellmar, L. Flemming, J. Haueisen. Skull
defects in MEG and EEG: Experimental results and
modelling. Poster presentation by S. Lau at 18th Int.
Conference on Biomagnetism. Paris, France, Aug
26–30, 2012, Book of Abstracts p. 231.
Mr Yi Yuen Wang
The expanding world of endoscopic skull
base surgery. St Vincent’s Hospital Surgical
Forum.В October 2012
Complications in Minimally Invasive Spine Surgery.
International Forum of Minimally Invasive Spine
Surgery. Shanghai September 2012
Minimally Invasive Spine Surgery – tips and tricks.
Ruijin Hospital, Shanghai September 2012
How I use spinal navigation in posterior lumbar
fusions. Melbourne Spine Research Group,
EpworthВ Hospital, Melbourne May 2012
Neurosciences Future Directions Strategy 2012–
2015. Management Forum, St Vincent’s Health
Australia, March 2012
Mr Christopher Thien
Minimally invasive lateral access spinal surgery.
St Vincent’s Hospital Surgical Forum. October 2012
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O’Brien Institute
The O’Brien Institute was established more
than 30 years ago as a surgical institute to
develop the now speciality of micro-vascular
surgery. TheВ Institute made striking advances
in replantation surgery, and the transfer by
microsurgical techniques, of body parts and
tissues to reconstruct people maimed by trauma,
cancer, burns and congenital deformity. It now
focuses on new methods of reconstruction
based on engineering principals, also called
Regenerative Surgery where it stimulated our
own body to grow tissues to repair or replace
damaged body parts and organs.
Key Projects:
About us
Heart failure is a life threatening condition and heart
transplantation remains the only resort for patients
with end-stage heart failure. However, the option of
heart transplantation has been limited by the severe
shortage of heart donors. Engineering heart tissue
with stem cell-derived heart cells can potentially
provide heart tissue to repair and regenerate the
damaged heart. The engineered human heart tissue
will also allow basic research to evaluate the efficacy
and safety of new drugs.
O’Brien Institute pursues leading edge and vital
research programs in regenerative surgery and
tissue engineering, with a primary focus on
translating advances in laboratories into clinically
successful therapies and treatments to patients
afflicted by injury, disease and abnormalities.
The Institute’s staff includes surgeons, research
scientists, surgical fellows, students and
administrative staff working under the direction
of Professor Wayne Morrison. The research
isВ essentially collaborative and multidisciplinary
andВ involves the basic science fields of stem
cell biology, vascular and lymphatic biology,
pharmacology, wound healing, matrix biology
andВ the effects of trauma and irradiation on tissue.
OBI has key collaborarations with University
ofВ Melbourne (Biomolecular Engineering), ACU,
CERA, St Vincent’s Institute and Medical Bionics.
• Development of new alternatives for breast
reconstruction – Neopec (chamber model)
andВ theВ layer by layer matrix injection approach
derived from a fat tissue extract.
• Development and testing of new scaffolds
andВ biomaterials for adipose tissue engineering
• The role of physical forces in soft tissue
engineering
• Understanding the role of fat injection
Cardiac Regeneration (Lim/Dusting)
Key Projects:
• Cardiac differentiation of human induced
pluripotent stem cells (iPSCs) and adult
mesenchymal stem cells with pharmacological
agents and electrical stimulation
• Cardiac tissue engineering with human
stem cell-derived cardiomyocytes
• Non-generic approaches to purify
stem cell-derived cardiomyocytes
Major projects
• The role of mitochondrial morphology in
stemВ cellВ survival and cardiac differentiation
Adipose Tissue Engineering/Matrix
BiologyВ (Abberton/Morrison)
Vascular Biology Group (Mitchell/Penington)
Soft tissues such as fat are used for reconstructive
surgery for replacement after injury or tumour
removal. Replacement fat tissue is also needed
forВ birth defects and contour filling. Current methods
toВ rebuild tissues often require multiple operations
and removing healthy tissue from another site
inВ the body to act as a donor. Implants can calcify
becoming painful and misshapen. We need
aВ betterВ way to grow new soft tissues.
The Vascular Biology Group has two main divisions
– studies on human vascular malformations and
studies on angiogenesis and implanted cell survival
in tissue engineering.
Key Projects:
• Studies on the endothelial cell biology of human
lymphatic malformations and creation of a murine
model of human lymphatic malformation
• The role of tissue factor pathway inhibitor (TFPI)
inВ biology human lymphatic malformations
st vincent’s research report 2012
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O’Brien Institute
• Studies on the effects of propranolol treatment
onВ human infantile haemangiomas
• The Neopec project has been successful
onaВ number of fronts including:
• Constructing liver tissue from multicellular
spheroids of liver and vascular cells.
–– having developed a number of
newВ manufacturing techniques
• Adipose derived mesenchymal cells can
beВ differentiated into insulin producing cells
–– gained a new understanding of the role of
biomaterials as implantable medical devices
• Constructing vascular and lymphatic capillary
networks from endothelial cell spheroids for
tissueВ reconstruction.
–– enhanced Victorian engineering design
andВ manufacturing capabilities for future
medicalВ devices
• Building �off the shelf’ tissue engineered flaps for
surgical reconstruction of skin and subcutaneous
tissue, bench to bedside applications
–– obtained new insights into factors that
governВ soft tissue engineering.
Neopec Pty Ltd. (Morrison/Abberton/O’Connor
(UniMelb Biomolecular Engineering)
The O’Brien Institute is the principal stakeholder
in Neopec Pty Ltd, a consortium, which included
St Vincent’s Hospital Melbourne, The University
of Melbourne, Cogentum Pty Ltd. and Anatomics
Pty Ltd. Neopec was supported by a Victorian
Government science and innovation grant totalling
$2.95 million over a three year period. The project
involved investigating a more natural choice for
breast reconstruction.
Project Outcomes:
• In October 2012, Neopec announced that it has
demonstrated proof of concept for breast tissue
growth using its breast reconstruction chamber
in a pilot human clinical trial. This trial followed
promising preclinical studies conducted by the
O’Brien Institute up to 2009 and prior to the
establishment of the Neopec consortium.
• The trial showed the concept to be safe
and well-tolerated by the patient.
• In one of the trial participants, the chamber had
filled with new tissue to replace that lost when
herВ breast was removed due to breast cancer.
This result is �proof of principle’ that the chamber
can provide the environment for replacement
tissue to grow in humans.
• The other patients showed no significant
tissueВ regeneration.
• More basic research is required before we
canВ justify conducting further human trials.
Stroke Brain Injury and Repair (Roulston/Dusting)
Stroke is the second most common cause of death
and leading cause of disability in Australia. In 2012,
itВ is predicted that Australians will suffer around
60,000 new and recurrent strokes, one stroke
every 10 minutes. Despite on-going research, there
is still no treatment proven to be effective for the
majority of victims. Injury to the brain often results
inВ permanent brain damage which is largely due to
aВ failure of nerve cells to re-grow into the injury site.
Key Projects:
• Angiogenesis and stem cell transplant for recovery
from ischaemic stroke. Collaborators: Centre
for Neural Tissue Engineering (The University
ofВ Melbourne), Minocycline treatment to reduce
inflammation and scar formation post-stroke
toВ support pre-differentiated stem cell transplants
• Role of truncated c-Src in neuronal death following
stroke and reperfusion: a collaborative study with
researchers from Bio21. Collaborators: Bio21
Institute, The University of Melbourne
Staff
Prof Wayne A Morrison, Director 0.2EFT
Prof Anthony Penington, Deputy Director 0.1EFT
(upВ to June 2012)
A/Proif Keren Abberton, Group Leader, Adipose
Tissue Engineering, Senior Research Officer 1.0EFT
A/Prof Geraldine Mitchell, Group Leader, Vascular
Biology, Senior Research Fellow 0.8EFT
Dr Carli Roulston, Group Leader, Stroke Injury
andВ Repair, Senior Research Officer 0.6EFT
Dr Max Lim, Senior Research Officer 1.0EFT
(fromВ May 2010)
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O’Brien Institute
Dr Zerina Lokmic, Research Officer 0.2EFT
(upВ toВ June 2012)
Nora Hakami, PhD student,
TheВ UniversityВ ofВ Melbourne
Effie Keramidaris, Tissue Engineering Laboratory
Co-ordinator 1.0EFT
Dr Heidi Debels, PhD Student (Belgium)
Jason Palmer, Histopathology Laboratory
Co-ordinator 1.0EFT
Dr Dong Geun Lee, Research Fellow
Dr Caroline Taylor, Molecular Laboratory
Co-ordinator 0.6EFT
Theses passed in 2012
Yi-wen Gerrand Research Assistant 1.0EFT
Xiao Lian Han, Research Assistant 0.8EFT
Nakisa Malacooti, Research Assistant 1.0EFT
(upВ toВ May 2012)
Laita Bokhari, Research Assistant 1.0EFT
(fromВ MayВ 2012)
Dr Chris Poon, Research Assistant 1.0EFT
(upВ toВ June 2012)
Jennifer Knowlson, Administration Manager 1.0EFT
Betty Scardaville, Accountant 1.0EFT
Tiffany Tran, Grants Officer, Executive Assistant
0.80EFT
Teri Wright, Administrative Assistant 0.3 EFT
Students
Hima Abeysinghe, PhD Student
Aaron Dingle, PhD Student
Michael Williams, PhD Student
Dr Keiran Rowe, PhD Student (left in February 2012)
Dr Masayoshi Higuchi, Research Fellow
Sarah Hsiao, PhD Student,
TheВ UniversityВ ofВ Melbourne
Service to the wider community
• Prof Wayne Morrison, Director: O’Brien Institute,
O’Brien Foundation, Neopec Pty Ltd; Member
ACU/OBI Regenerative Tissue Engineering
Committee (AORTEC); Member Aikenhead Centre
for Discovery Medicine (ACMD)
• Prof Anthony Penington, (until June 2012)
Member ACU/OBI Regenerative Tissue
Engineering Committee (AORTEC)
• A/Prof Geraldine Mitchell, NHMRC Grant
ReviewВ Panel, Director ACU/OBI Regenerative
Tissue Engineering Committee (AORTEC),
Member, St Vincent’s Hospital Research Week
Organising Committee; Eastern Hill Research
Training Committee
• A/Prof Keren Abberton, St Vincent’s Hospital
Animal Ethics Committee; Editorial Board for
the I:В ISRN Obesity; Committee Member of the
Australian and New Zealand Microcirculation Society.
Dr Richard Tee, PhD Student
Grants
Sarah McCann, PhD Student
Dusting GJ, Dilley R, Pebay AM,
LimВ SY,В Shepherd R
Upscaling cardiac tissue engineering. Differentiation
of iPS cells enrichment and bionic approaches,
NHMRC
$685,710 for 2012–2013 ($228,570 in 2012)
Dr Virginia Cotta D Med Sci Student
(leftinВ February,В 2012)
Dr Jenny Than (PhD student – withdrawn)
Visiting students
(enrolled in another University of Melbourne
Department but completing their PhD research
work at the O’Brien Institute):
Frisca Frisca, PhD Student, The
UniversityВ ofВ Melbourne
Karl Brown, PhD Student,
TheВ UniversityВ ofВ Melbourne
Zara Asgari, PhD Student,
TheВ UniversityВ ofВ Melbourne
Mitchell GM, Peters H, Yeoh G, Morrison, WA
Development of functional liver tissue engineered
from murine hepatocyte or liver progenitor cell
spheroids to correct liver disease, NHMRC
$443,645 for 2012–2014 ($129,342 in 2012)
Abberton, KM
New methods for growing adipose tissue for breast
reconstruction post mastectomy, Breast Cancer
Research Association Inc
$198,102 for 2011–2012 ($99,051 in 2012)
st vincent’s research report 2012
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O’Brien Institute
O’Brien Institute
Histology equipment, Joe White Bequest
$30,000 for 2012
• Cogentum – Melbourne
Dusting GJ, Roulston C, Crook JM, Kobayashi N
NADPH oxidase and brain repair after ischaemic
stroke, NHMRC
$618,975 for 2011–2013 ($235,326 in 2012)
• Murdoch Children’s Research Institute
O’Brien Institute
ACU-OBI Regenerative tissue engineering centre
(AORTEC), Australian Catholic University
$2,992,716 for 2012–2013 ($644,468 in 2012)
• The University of Melbourne – Melbourne
Mitchell GM
Building off the shelf tissue engineered flaps for
surgical reconstruction of sub-cutaneous fat tissue,
Jack Brockhoff Foundation
$49,861 for 2012
• University of Western Australia
Pebay A
Modulation of inflammatory lipids to improve
theВ outcome of neurotrauma, Transport Accident
Commission – Victorian Neurotrauma Initiative
$289,182 for 2011–2013 ($45,000 in 2012
(untilВ May 2012 when it was transferred
toВ CERAВ upon her resignation from OBI))
SY Lim
Human resident cardiac stem cells for cardiac
tissue engineering, St Vincent’s Hospital
$15,000 for 2012
GM Mitchell
Constructing vascular and lymphatic capillary
networks from endothelial cells spheroids for
tissue reconstructions, St Vincent’s Hospital
$15,000 for 2012
Collaborations in research
International
• University College London (UK)
• CSIRO
• University of Ghent, Belgium
National
• Anatomics – Melbourne
• Australian Catholic University – Melbourne
• CSIRO
• Monash University
• St. Vincent’s Hospital – Melbourne
• St. Vincent’s Institute – Melbourne
• Centre for Neural Engineering
• Department of Chemical and Biomolecular
Engineering
Publications
Book chapters
Mitchell GM, Lokmic Z, Sinha S and Morrison
WA. (2012) Skin Flap Models for Assessment
ofВ Angiogenesis. In: The Textbook of Angiogenesis
and Lymphangiogenesis: Methods and Applications
(Cuttita, E. Z. a. F., ed) pp. 375–416, Springer
Science & Business Media Dordrecht, Heidelberg,
New York, London
Journal articles
Williams, M. D., and Mitchell, G. M. (2012)
MicroRNAs in Insulin Resistance and Obesity.
ExpВ Diabetes Res 2012, 484696
Tilkorn, D. J., Davies, E. M., Keramidaris, E.,
Dingle, A. M., Gerrand, Y. W., Taylor, C. J., Han, X.
L., Palmer, J. A., Penington, A. J., Mitchell, C. A.,
Morrison, W. A., Dusting, G. J., and Mitchell, G.
M. (2012) The in vitro preconditioning of myoblasts
toВ enhance subsequent survival in an in vivo tissue
engineering chamber model. Biomaterials 33,
3868–3879.
Tee, R., Morrison, W. A., Dusting, G. J., Liu, G. S.,
Choi, Y. S., Hsiao, S. T., and Dilley, R. J. (2012)
Transplantation of engineered cardiac muscle flaps
in syngeneic rats. Tissue Eng Part A 18, 1992–1999.
Taylor, C. J., Satoor, S. N., Ranjan, A. K.,
PereiraВ eВ Cotta, M. V., and Joglekar, M. V. (2012)
A protocol for measurement of noncoding RNA
inВ human serum. Exp Diabetes Res 2012, 168368
• Bio21 – Melbourne
• Bionics Institute (Australia) – Melbourne
• Centre for Eye Research (CERA) – Melbourne
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O’Brien Institute
Stubbs, S. L., Hsiao, S. T., Peshavariya, H. M.,
Lim,В S. Y., Dusting, G. J., and Dilley, R. J. (2012)
Hypoxic preconditioning enhances survival of human
adipose-derived stem cells and conditions endothelial
cells in vitro. Stem Cells Dev 21, 1887–1896
Srisuwan, T., Tilkorn, D. J., Al-Benna, S., Vashi, A.,
Penington, A., Messer, H. H., Abberton, K. M., and
Thompson, E. W. (2012) Survival of rat functional
dental pulp cells in vascularized tissue engineering
chambers. Tissue Cell 44, 111–121
Srisuwan, T., Tilkorn, D. J., Al-Benna, S.,
Abberton,В K., Messer, H. H., and Thompson, E. W.
(2012) Revascularization and tissue regeneration
of an empty root canal space is enhanced by a
direct blood supply and stem cells. Dent Traumatol.
29(2):84–91
Ranjan, A. K., Joglekar, M. V., Atre, A. N., Patole, M.,
Bhonde, R. R., and Hardikar, A. A. (2012) Cellular
detection of multiple antigens at single cell resolution
using antibodies generated from the same species.
J Immunol Methods 379, 42–47
Ranjan, A. K., Joglekar, M. V., Atre, A. N., Patole,
M., Bhonde, R. R., and Hardikar, A. A. (2012)
Simultaneous imaging of microRNA or mRNA
territories with protein territory in mammalian cells
at single cell resolution. RNA Biol 9, 949–953
Nguyen, P. D., Hsiao, S. T., Sivakumaran, P., Lim,В S.
Y., and Dilley, R. J. (2012) Enrichment of neonatal
rat cardiomyocytes in primary culture facilitates
long term maintenance of contractility in vitro.
Am J Physiol Cell Physiol 03(12):C1220–8
Liu, G. S., Peshavariya, H., Higuchi, M., Brewer,В A. C.,
Chang, C. W., Chan, E. C., and Dusting, G. J. (2012)
Microphthalmia-associated transcription factor
modulates expression of NADPH oxidase typeВ 4:
aВ negative regulator of melanogenesis. FreeВ Radic
Biol Med 52, 1835–1843
Lim, S. Y., Lee, D. G., Sivakumaran, P., Crombie,В D.,
Slavin, J., Dottori, M., Conley, B., Denham, M.,
Leung, J., Tee, R., Dusting, G. J., Pebay, A.,
and Dilley, R. J. (2012) In vivo tissue engineering
chamber supports human induced pluripotent
stem cell survival and rapid differentiation.
Biochem Biophys Res Commun 422, 75–79
Lim, S. Y., Hsiao, S. T., Lokmic, Z., Sivakumaran,В P.,
Dusting, G. J., and Dilley, R. J. (2012) Ischemic
preconditioning promotes intrinsic vascularization
and enhances survival of implanted cells in an in
vivo tissue engineering model. Tissue Eng Part A
18, 2210–2219
Lim, S. Y., and Hausenloy, D. J. (2012) Remote
ischemic conditioning: from bench to bedside.
Frontiers in Physiology 3, 27
Ladewig, K., Abberton, K., and O’Connor A, J.
(2012) Designing in vivo bioreactors for soft tissue
engineering. Journal of Biomaterials and Tissue
Engineering 2, 1–13
Khong, S., Andrews, K., Huynh, N., Venardos,
K., Aprico, A., Michell, D., Zarei, M., Moe, K.,
Dusting,В G., Kaye, D., and Chin-Dusting, J. (2012)
Arginase II inhibition prevents nitrate tolerance.
Br J Pharmacol 166, 2015–2023
Joglekar, M. V., and Hardikar, A. A. (2012) Isolation,
expansion, and characterization of human isletderived progenitor cells. Methods Mol Biol 879,
351–366
Hsiao, S. T., Asgari, A., Lokmic, Z., Sinclair, R.,
Dusting, G. J., Lim, S. Y., and Dilley, R. J. (2012)
Comparative analysis of paracrine factor expression
in human adult mesenchymal stem cells derived
from bone marrow, adipose, and dermal tissue.
Stem Cells Dev 21, 2189–2203
Goldshmit, Y., Matteo, R., Sztal, T., Ellett, F.,
Frisca,В F., Moreno, K., Crombie, D., Lieschke,В G.
J., Currie, P. D., Sabbadini, R. A., and Pebay,В A.
(2012) Blockage of lysophosphatidic Acid
signalingВ improves spinal cord injury outcomes.
Am J Pathol 181, 978–992
Frisca, F., Sabbadini, R. A., Goldshmit, Y.,
and Pebay, A. (2012) Biological effects of
lysophosphatidic acid in the nervous system.
Int Rev Cell Mol Biol 296, 273–322
Chew, G. L., Huang, D., Lin, S. J., Huo, C.,
Blick,В T., Henderson, M. A., Hill, P., Cawson, J.,
Morrison,В W.В A., Campbell, I. G., Hopper, J. L.,
Southey, M. C., Haviv, I., and Thompson, E. W.
(2012) High and low mammographic density human
breast tissues maintain histological differential in
murine tissue engineering chambers. Breast Cancer
Research and Treatment 135, 177–187
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O’Brien Institute
Ansarullah, Bharucha, B., Umarani, M., Dwivedi,В M.,
Laddha, N. C., Begum, R., Hardikar, A. A.,
and Ramachandran, A. V. (2012) Oreocn ide
integrifolia Flavonoids Augment Reprogramming
for Islet Neogenesis and beta-Cell Regeneration
in Pancreatectomized BALB/c Mice. Evid Based
Complement Alternat Med 2012, 260467
Conference publications
Abeysinghe H, Malakooti N, Crook J, Dusting GJ,
Roulston, CL, Kobayashi NR. Pre-differentiation
of subventricular zone derived human neural stem
cells enhances neuronal repopulation following
transplantation within the stroke damaged brain.
International Society for Stem Cell Research
(ISSCR)В 2012; Yokohama, Japan, June 2012. :
(Poster presentation)
Abeysinghe H, Malakooti N, Bokhari L, Crook J,
Dusting GJ, Roulston, CL, Kobayashi NR. Neural
progenitor cells pre-differentiated prior to transplant
promote neuron repopulation within the stroke
damaged brain. World Stroke Congress 2012;
Brasilia, Brazil, October 2012. (Poster presentation)
GM Mitchell, DJ Tilkorn, Z Lokmic, AM Dingle,
K Yap, SO Hofer, MD Williams, JA Rophael,
AJВ Penington, and WA Morrison, Enhancing
implanted cell survival in in vivo tissue engineering.
J Tissue Eng Regen Med 2012; 6 (Suppl. 1):
1–429. Page 300, (50.p23) Presented at: Tissue
Engineering and Regenerative Medicine Society
(TERMIS) meeting, Vienna, September, 2012
MD Williams, E Keramidaris, MV Joglekar,
GMВ Mitchell and AA Hardikar: Differentiation
ofВ adipose-derived mesenchymal cells to endocrine
pancreatic lineage J Tissue Eng Regen Med 2012;
6 (Suppl. 1): 1–429. Pg 267 (43.04) Presented
at:В Tissue Engineering and Regenerative
Medicine Society (TERMIS) meeting,
Vienna,В September, 2012
AM Dingle, K Yap, WA Morrison, HL Peters,
GCВ Yeoh and GM Mitchell Pre-vascularising liver
progenitor cell spheroids in vitro to increase survival
in vivo. J Tissue Eng Regen Med 2012; 6 (Suppl. 1):
1–429. Page 309 (51.P09) Presented at: Tissue
Engineering and Regenerative Medicine Society
(TERMIS) meeting, Vienna, September, 2012
Speaking engagements
Buncke Lecturer, Maximising Aesthetics in
Reconstructive Breast Surgery: American Society
for Reconstructive Microsurgery, Red Rock, USA,
January 2012 Prof Wayne Morrison
Regenerative Surgery; experimental and clinical
experiences: 5th Annual Joseph E. Murray
Invitation,В Harvard University, USA, March 2012
ProfВ Wayne Morrison
Progress in Tissue Engineering for Breast
Reconstruction: Sydney Breast Cancer Congress,
Sydney, Australia, May 2012 Prof Wayne Morrison
Progress in Tissue Engineering for Breast
Reconstruction, Sydney Breast Cancer
Congress,В Sydney, Australia: October 2012,
ProfВ Wayne Morrison
55th International Surgical Group Meeting –
Hong Kong ; November 2012 – Prof Wayne Morrison
Innovations in Plastic Surgery: 81st Royal
Australasian College of Surgeons Annual Scientific
Congress, Kuala Lumpur, Malaysia, May 2012
ProfВ Wayne Morrison
Human Induced Pluripotent Stem Cells for
Cardiac Tissue Engineering. (Best moderated
oral poster presentation). St Vincent’s Research
Week. (Melbourne, Australia). 2012 August. SY Lim
Ischemic Preconditioning for Cardiac Tissue
Engineering with Stem Cells. (Oral presentation).
TERMIS World Congress (Vienna, Austria). 2012
September.SY Lim
Ischemic Preconditioning Promotes Intrinsic
Vascularisation and Enhances Growth of Cardiac
Tissue. (Oral presentation, Young investigator
award). International Society of Hypertension.
(Sydney, Australia). 2012 October. SY Lim
Cardiac Tissue Engineering with Human Induced
Pluripotent Stem Cells Derived from Friedreich’s
Ataxia Patient. (Oral presentation). Friedreich Ataxia
National Research Meeting (Melbourne, Australia).
2012 November. SY Lim
Pre-vascuraising liver progenitor cell spheroids
in vitro to increase survival in vivo, 3rd Tissue
Engineering and Regenerative Medicine International
Society Congress, Vienna, Sept. 2012 A Dingle
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O’Brien Institute
Pre-vascuraising liver progenitor cell spheroids
in vitro to increase survival in vivo, Australian
Health and Medical Research Congress, Adelaide,
Nov. 2012, A Dingle
Differentiation of adipose-derived stem cells
into fat involves reactive oxygen species and
upregulation of antioxidant enzymes, International
Society of Hypertension, Sydney, October 2012:
MВ Higuchi (Oral presentation)
Pre-differentiation of human neural progenitor
cells enhances neuronal repopulation following
transplantation within the stroke damaged brain,
Australian Neuroscience Society Annual Conference
2012; Gold Coast, Australia. February 2012.
(OralВ presentation) : H Abeysinghe
Enhancing implanted cell survival in in vivo tissue
engineering. Oral presentation at the AH&MRC
Congress, Adelaide, November, 2012. GM Mitchell
Effects of biophysical and biochemical
environment on preadipocyte differentiation.
TERMIS –3rd World Congress: Vienna September
5thВ Poster Presentation: KA Abberton
An adipoinductive role of inflammation
inВ adipose tissue engineering: key factors
inВ theВ early development of engineered
soft tissues. AHMRC 6th National conference
AdelaideВ November 25th 28th. Poster Presentation.
KAВ Abberton
LPA Receptor distribution and effect of inhibition
in the rate brain following endothelin-1 induced
stroke. Australian Neuroscience Society Annual
Conference 2012; Gold Coast, Australia. February
2012. (poster presentation) Smith X., Malakooti N.,
Pebay A. and Roulston C.
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Oncology
St Vincent’s Department of Oncology
isВ committed to supporting and conducting
clinical trials in collaboration with Australian
and international clinical trial groups, to
directly influence the treatment practice
andВ management of cancer.
About us
The Department of Oncology provides a
multidisciplinary approach to patient management
thatВ emphasises the importance of optimising all
aspects of the patient’s wellbeing.
Medical Oncology, together with disciplines such
asВ surgery, pathology, radiology, radiation oncology,
allied health and supportive care services meet
regularly at multidisciplinary meetings to discuss
optimal treatment plans for patients. It is hoped
thatВ these meetings will improve outcomes for
newlyВ diagnosed patients and identify patients
whoВ are potentially eligible for clinical trials.
PatientsВ can also access clinical trials via satellite
clinics at Shepparton, Echuca, St. Vincent’s
&В MercyВ Private, and Werribee Hospitals.
The Department has been operating for over
30В years and has taken part in over 130 clinical
trialsВ involving approximately 2,100 patients.
We participate in trials that treat patients who
haveВ either early stage disease and/or advanced
cancer. Our research involves investigating new
drugВ treatments for various phases of cancer
(including prevention) as well as studies of
psychosocial support.
Trials are usually conducted in collaboration
with Australian and international trials groups.
Patients who consent to take part receive either
the best known treatment or a new treatment
program building on the current standard of
care. As a secondary benefit, doctors are able
toВ gain firsthandВ experience of these new agents
in aВ controlled clinical setting before they are
widelyВ available.
The Department is currently involved in clinical trials
in tumours of the breast, colon, lung, lymph nodes,
brain, pancreas, stomach, biliary tract, kidney and
liver. These are usually Phase II and III randomised
clinical trials.
Major projects
• Randomised, open label, multi-centre study
comparing Cabazitaxel at 25mg/m2 and at 20mg/
m2
in combination with Prednisone every 3 weeks
toВ Docetaxel in combination with Prednisone
inВ patients with metastatic castration resistant
prostate cancer not pretreated with chemotherapy
• Randomised, open label multi-centre study
comparing Carbazitaxel at 20mg/m2 and at 25mg/
m2
every 3 weeks in combination with Prednisone
for the treatment of metastatic castration
resistant prostate cancer previously treated with
a docetaxel-containing regimen. The Proselica
Study
• The utility of genomics and functional imaging
to predict irinotecan Pharmacokinetics and
Pharmacodynamics: The PREDICT study
ProtocolВ No. 10/55
• A randomised phase II/III trial of preoperative
chemoradiotherapy versus preoperative
chemotherapy for resectable gastric cancer
• A trial in the timing of surgery and adjuvant
chemotherapy for hepatic metastases from
colorectal cancer
• Phase II Trial of Panitumumab, Cisplatin
andВ Gemcitabine in biliary tract Cancer
• A phase III, randomised trial of adding nitroglcerin
toВ first line chemotherapy for advanced non-small
cell lung cancer
• A phase III study of the impact of a physical
activity program on disease free survival in
patients with high risk or stage III colon cancer: a
randomised controlled trial
• The development of a sustainable model to
provide brief supportive care interventions to
underserved cancer patients
• A randomised phase II study of carboplatin
andВ bevacizumab in recurrent glioblastoma
multiforme (GBM)
• A Randomised, Double-Blind, Placebo-Controlled,
Multi-Center Phase 3 Study of Denosumab as
Adjuvant Treatment for Women with Early-Stage
Breast Cancer at High Risk of Recurrence
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• A Phase 2 trial of everolimus alternating with
sunitinib as first line therapy for patients with
advanced renal cell carcinoma
• Phase III randomised trial of BIBW 2992
plus weekly paclitaxel versus investigator’s
choice ofВ chemotherapy following BIBW 2992
monotherapyВ inВ NSCLC patients failing previous
erlotinib or gefitinib treatment
• A Phase II Randomised, Open-Label, Multicenter
Study Comparing CO-1.01 with Gemcitabine
as First-Line Therapy in Patients with Metastatic
Pancreatic Adenocarcinoma
• A Multicenter, Multinational, Randomized,
Double-Blind, Phase III Study of IMC-1121B
Plus Docetaxel Versus Placebo Plus Docetaxel
inВ Previously Untreated Patients with HER2Negative, Unresectable, Locally-Recurrent
orВ Metastatic Breast Cancer
• An Open Label Randomised Phase III Trial of
BIBW 2292 and Vinorelbine versus Trastuzumab
and Vinorelbine in Patients with Metastatic HER2overexpressing breast cancer failing one prior
trastuzumab treatment
• A multi-centre, randomised, double-blind, placebo
controlled, phase III study of single-agent Tarceva
(erlotinib) following complete tumour resection
withВ or without adjuvant chemotherapy in patients
with stage IB-IIIA non small cell lung carcinoma
whoВ haveВ EGFR-positive tumours.
• MAGE-A3 positive non small cell lung cancer,
doubleВ blind, randomised, placebo controlled
PhaseВ III study to assess the efficacy of
recMAGE-A3 + AS15 antigen specific cancer
immunotherapeutic as adjuvant therapy in
patientsВ with resectable MAGE-A3 positive
nonВ smallВ cell lung cancer.
• Multi centre international study of Capecitabine
+ or – bevacizumab as adjuvant treatment of
colonВ cancer.
• A phase III randomised study of Brivanib Alaninate
(bms 582664) in combination with Cetuximab
(Erbitux) versus placebo in combination with
Cetuximab (Erbitux) in patients previously treated
with combination chemotherapy for metastatic
colorectal carcinoma.
• Preferences for adjuvant chemotherapy in non
small cell lung cancer: what makes it worthwhile
toВ patients and their doctors?
versus placebo in post-menopausal women
atВ increased risk of breast cancer.
• An international multi centre study of tamoxifen
versus anastrazole in postmenopausal women
withВ hormone sensitive Ductal Carcinoma in Situ.
• A randomised, double blind trial to assess
the effectsВ on bone mineral density and bone
biomarkersВ ofВ anastrozole when used to prevent
breast cancer in postmenopausal women.
• Bisphosphonate and Anastrazole trial –
boneВ maintenance algorithm assessment.
• Phase III trial of LHRH Analog administration
during chemotherapy to reduce ovarian failure
following chemotherapy in early stage, hormone
receptor negative breast cancer.
• A phase III trial evaluating the role ovarian function
suppression and the role of exemestane as
adjuvant therapies for premenopausal women with
endocrine responsive breast cancer.
• An international multi centre open label 2 arm
phaseВ III trial of adjuvant bevacizumab in triple
negative breast cancer.
• A study to document the clinico-pathological
characteristics of patients with a first diagnosis
ofВ relapsed or de-novo metastatic breast cancer
inВ Australia and New Zealand
• A double-blind, randomised, multiple dose, Phase
III, multicentre study of Alpharadin in the treatment
of patients with symptomatic hormone refractory
prostate cancer with skeletal metastases
• Answering the unanswered questions about
psychosocial risk screening in the cancer setting
• Does a multidisciplinary face-to-face pre-operative
supportive care educational and counselling
intervention prior to major head and Neck Cancer
Surgery assist post-operative adjustment more
thanВ standard care?
• Targeting Breast Cancer Recurrence through
Epithelial Mesenchymal Plasticity
• The development of a sustainable model to
provide brief supportive care interventions to
underserved cancer patients
• An examination of the processes and dynamics
ofВ cancer multidisciplinary meetings
• Establishing a link between inflammation and EGFRmutant non-small cell lung cancers (NSCLCs)
• An international multi centre study of Anastrozole
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Staff
A/Prof Raymond Snyder, Medical Oncologist
1.0В EFT
A/Prof Sue-Anne McLachlan Medical Oncologist
1.0В EFT
Dr Anthony Dowling, Medical Oncologist 1.0 EFT
Dr Melissa Moore, Medical Oncologist 1.0 EFT
Dr Genni Newnham, Medical Oncologist 0.6 EFT
Dr Prue Francis, Medical Oncologist 0.2 EFT
Dr Bianca Devitt, Research Fellow 0.2 EFT
Nadia Ranieri, Clinical Trial Manager 0.6 EFT
Debbie Gaitanis, Clinical Trial Coordinator 1.0 EFT
Melissa Moore, PhD, University of Sydney.
“The Molecular Pathogenesis of the Cancer
Cachexia Syndrome.”
Service to the wider community
A/Prof Raymond Snyder
• Director of Cancer Services, St Vincent’s Hospital
• Principal Fellow (Assoc Professor) Department
of Medicine, St Vincent’s Hospital
• Medical Oncology Group Australia – Oncology
Drug Register of Experts: Breast Cancer
• Member, Cancer Trials Australia –
Melbourne,В Australia
Leeanne Pasanen, Clinical Trial Coordinator 0.4 EFT
• Member Breast Cancer Committee (VCOG)
(PastВ Chairman)
Amber Degelia Clinical Trial Coordinator 1.0 EFT
(tillВ Aug 2012)
• Member Australasian Germ Cell Trial Group
Rosie Brown, Research Assistant.0.4 EFT
Carrie Lethborg, Co-ordinator Psychosocial
CancerВ Research, 0.2EFT
Pauley Kessel, Research Assistant, (from July 2012)
0.2EFT
Students
Dr Bianca Devitt. Ph D. University of Melbourne,
Faculty of Medicine, Dentistry and Health Sciences.
An examination of the dynamics and processes
of multidisciplinary cancer meetings. Recipient of
Victorian Cancer Agency scholarship. Supervisors
SA McLachlan and Jenny Philip
Dr Heather Lane. PhD. University of Melbourne,
Faculty of Medicine, Dentistry and Health
Sciences. How do older people with cancer
andВ their healthcare professional make decisions
about cancer treatment? Recipient of University
of Melbourne, Faculty of Medicine postgraduate
scholarship. Supervisors J Philip and SA McLachlan
• Member International Breast Cancer Study Group
• Member Psycho-oncology Group, VCOG
(PastВ Chairman)
• Member, Board Victorian Breast Cancer
ResearchВ Consortium
• Member, Scientific advisory committee,
ANZВ BCTG
• Chairman, Committee of Management,
EasternВ Pall. Care (2008- )
• Member, Standing Research
Sub-Committee,В CCV
A/Prof Sue-Anne McLachlan
• Member of VCOG Committee
• NHMRC, National Breast Cancer Centre, Editorial
committee for Clinical Update publication
• Consortium for Research into Familial Breast
Cancer (kConFab)
Dr Tim Clay. Doctor of Medical Science by Thesis.
Adenocarcinoma of the lung – correlation of
detailed histopathological subtyping and molecular
pathology with clinical features and outcome.
Recipient of University of Melbourne, Faculty of
Medicine postgraduate scholarship. Supervisors
SAВ McLachlan, M Moore, P Russell
Theses passed in 2012
st vincent’s research report 2012
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Oncology
• Victorian Clinical Oncology Group: breast
trials subcommittee, Gastrointestinal trials
subcommittee, Psycho-oncology committee
andВ Cancer genetics committee
• Western Integrated Cancer Services,
UpperВ gastro-intestinal tumour group
Dr AJ Dowling
• Victorian Cooperative Oncology Group (VCOG)
Committee The Cancer Council Victoria
• Victorian Cooperative Oncology Group
ExecutiveВ Committee
• Urological Cancer Committee (Sub-committee
ofВ the Victorian Cooperative Oncology Group),
TheВ Cancer Council Victoria
• Neuro-Oncology Committee (Sub-committee
ofВ the Victorian Cooperative Oncology Group),
TheВ Cancer Council Victoria
• Written Examination Committee – Adult Medicine
– The Royal Australasian College of Physicians
Management and Advisory Committee – Western
and Central Melbourne Integrated Cancer Service
Dr Prue Francis
• Chair, International Steering Committee for STP
Adjuvant Breast Cancer Trials, (SOFT: IBCSG
24–02, TEXT: IBCSG 25–02 and PERCHE: IBCSG
26–02)
• International Study Chair for Breast
InternationalВ Group (BIG)/ IBCSG trial:
BIG 02–98 (IBCSG 20–98, Adjuvant Taxotere)
• International Study Chair for Breast
InternationalВ Group (BIG)/ IBCSG trial:
BIG 2–02 (IBCSG 24–02, SOFT)
• Scientific Committee – International Breast
CancerВ Study Group (IBCSG)
• International Advisory Board The Breast (journal)
• Scientific Advisory Committee – Australian New
Zealand Breast Cancer Trials Group (ANZ BCTG)
• European School of Oncology (ESO)
– Metastatic Breast Cancer – Task Force
• Chair, Breast Trials Sub-Committee
– The Cancer Council Victoria
• Breast Cancer Committee
– The Cancer Council Victoria
• National (ANZ BCTG) Chair for trials: BIG 02–98
(Adjuvant Taxotere), IBCSG 24–02 (SOFT), IBCSG
25–02 (TEXT)
• Associate Professor Department of Medicine
St Vincent’s Hospital The University of Melbourne
• Cancer Trials Australia (CTA) Breast Tumour Group
• Vice Chair Scientific Advisory Committee
ANZBCTG
• NHMRC Project Grant review
• Cancer Research UK grant review
Dr Genni Newnham
• Member Victorian Co-operative Oncology Group
• Member Lung Cancer Committee (subgroup
ofВ Victorian Co-operative Oncology Group)
• Member Australasian Lung Cancer Trials Group
• Member Medical Oncology Group of Australia
• Member Cancer Trials Australia (Melbourne)
Dr Melissa Moore
• Member – Cancer Trials Australia Breast
TumourВ Group
• Member – Victorian Co-operative Oncology
GroupВ (VCOG) Breast Cancer Committee
Dr Carrie Lethborg
• Executive Member – Victorian Co-operative
Oncology Group (VCOG) Executive,
(First non-medical member appointed)
• Invited Member – Clinical Management Advisory
Team – Western and Central Melbourne Integrated
Cancer Services (WCMICS)
• Chair – Supportive Care Advisory Committee
– WCMICS
• Invited Member – DOH Victoria, Cancer
Survivorship Steering Committee
• Executive Member – Oncology Social Work
Australia (OSWA)
• Executive Member – Cancer Social Work Victoria
• Invited Member – DOH Victoria, Supportive Care
Evaluation Expert Reference Group
• Editorial Board Member The Journal of Palliative
and Supportive Care
• Peer Reviewer – Psycho-oncology, The Journal
ofВ Psychosocial Oncology, The Journal of Palliative
and Supportive Care
• Ph D confirmation panel – Deakin University
(Psychology)
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Oncology
• Ph D confirmation assessor –
UniversityВ ofВ Melbourne (Medicine)
• Assessor (Master in Psychology –
Monash University, Social Work Masters –
Flinders University, PhD – Monash University)
• Honorary Post-Doctoral Fellow (Peter MacCallum
Cancer Centre and University of Melbourne)
Grants
Thompson, E., Goodall, G,
Saunders,В C,В Anderson, R, Yap, A,
Street,В I,В Dobrovic,В A.,В &В Dowling, A.
Targeting Breast Cancer Recurrence
throughВ Epithelial Mesenchymal Plasticity,
NationalВ Collaborative Breast Cancer
ResearchВ Grant Program
$5,150,286 for 5 years ($110,000 in 2012)
Phillips KA, Hopper JL, Friedlander ML,
McLachlan SA, Milne R, Goldgar.
Preventing Breast Cancer in BRCA1 and BRCA2
Mutation Carriers: kConFab Follow-Up Project.,
National Breast Cancer Foundation and Cancer
Australia #628333 Chief Investigator.
$588,937 for 3 years ($97,000 in 2012)
McLachlan SA, Duric V, Stockler MR,
NowakВ AK,В Wright G, Boyer M
Preferences for adjuvant chemotherapy (ACT)
inВ non-small cell lung cancer: What makes
it worthwhile for patients and their doctors.,
CancerВ Australia
$287,425 for 5 years ($59,000 in 2012)
Lethborg C, Brown R, Snyder R, Kessel P,
Posenelli S, Dunn W, Packer C, Smith L, Horden A
The development of a sustainable model to provide
brief supportive care interventions to underserved
cancer patients, Western and Central Melbourne
Integrated Cancer Services
$89,971.72 for 2012–2013 ($45,000.00 in 2012)
Devitt, B
An examination of the processes and
dynamics ofВ cancer multidisciplinary meetings,
VictorianВ Cancer Agency
$67,162 for 2009–2012 ($29, 755 in 2012)
Melissa Moore
Establishing a link between inflammation and
EGFR-mutant non-small cell lung cancers (NSCLCs),
St Vincent’s Research Directorate
$15,000 for 2012
Chua B, Joseph D, Francis P, Campbell I.
A phase III trial of post-mastectomy chest wall
irradiation in intermediate risk operable breast
cancer, Cancer Australia
$510,000 for 2011–2013 ($170,000 in 2012)
Anderson R, Street I, Lakhani S. Fox, S, Zeps N,
Hodgkinson S, Francis P, Bast R.
Targeting dormancy in metastatic breast cancer,
Cancer Australia
$571,010 for 2012–2014 ($190, 000 in 2012)
Lindeman G, Mann B, Desai J, Forbes J, FoxВ S,
Liew D, McArthur G, Simes J, Sutherland J,
Visvader J. Wilcken N, Rosenthal M, Street I,
Macphee A, Ormandy C, Swarbick A, O’Toole S,
Boyer M, Horvath L, Campbell I, JohnstoneВ R,
Simpson E, Chua B, Francis P, Mitchell G,
GreenВ M, De Boer R, Scott C.
Centre for Translational Research in Breast Cancer,
NHMRC
$2,500,000 for 2012–2017 ($500,000 in 2012)
Collaborations in research
Dr Prue Francis
• Scientific Committee – International Breast Cancer
Study Group (IBCSG)
• Chair, Steering Committee for STP Adjuvant
Breast Cancer Trials – (SOFT: IBCSG 24–02,
TEXT: IBCSG 25–02 and PERCHE: IBCSG 26–02)
• European School of Oncology (ESO)
• Metastatic Breast Cancer – Task Force
• Chair, Systemic Therapy Subcommittee
• Scientific Advisory Committee – Australia
andВ NewВ Zealand Breast Cancer Trials Group
(ANZВ BCTG)
Dr Carrie Lethborg
• Centre for Palliative Care and Education,
Melbourne
• Peter MacCallum Cancer Centre
• Werribee Mercy Hospital
• Goulburn Valley Health
st vincent’s research report 2012
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Oncology
Publications
Book chapters
Kissane DW, Lethborg CE, Kelly B. 2012. Spiritual
and Religious Coping with Cancer, In L Grassi
and M Riba (eds), Clinical Psycho-Oncology:
An International Perspective, London, WileyBlackwell (Pp 281–296), ISBN: 978–0–470–97432–2.
Journal articles
Aranda S, Jefford M, Yates P, Gough K, Seymour J,
Francis P, Baravelli C, Breen S, Schofield P. (2012)
Impact of a novel nurse-led prechemotherapy
education intervention (ChemoEd) on patient
distress, symptom burdern, and treatment-related
information and support needs: results from
aВ randomized controlled trial. Ann Oncol: 23;
222–231.
Cardoso F, Costa A, Norton L, Cameron D, CuferВ T,
Fallowfield L, Francis P, Gligorov J, Kyriakides S,
Lin N, Pagani O, Senkus E, Thomssen C, Aapro M,
Bergh J, Di Leo A, El Saghir N, Ganz PA, GelmonВ K,
Goldhirsch A, Harbeck N, Houssami N, Hudis C,
Kaufman B, Leadbeater M, Mayer M, Rodger A,
Rugo H, Sacchini V, Sledge G, van’t Veer L, Viale G,
Krop I, Winer E. (2012) 1st International consensus
guidelines for advanced breast cancer (ABC1).
The Breast; 21: 242–252.
Eckhardt BL, Francis PA, Parker BS, Anderson
R. Strategies to consider during the discovery
andВ development of therapies for metastatic
breastВ cancer. (2012) Nature Reviews Drug
Discovery: 11 (6); 479–497.
Fernandez-Cuesta L, Oakman C, Falagan-LotschВ P,
Smoth KS, Quinaux E, Buyse M, DolciВ MS,
De Azambuja E, Hainaut P, Dell’Orto P, Larsimont D,
Francis P, Crown J, Piccart-Gebhart M, VialeВ G,
DiВ Leo A, Olivier M. (2012) Prognostic and
predicitive value of TP53 mutations in node-positive
breast cancer patients treated with anthracyclineorВ anthracycline/taxane based adjuvant therapy:
results from the BIG 02–98 phase III trial. Breast
Cancer Res; 14 (3): R70
Lethborg C, Schofield P, Kissane D, (2012),
TheВ patient experience of undertaking Meaning
and Purpose �MaP’ Therapy in the setting
ofВ advanced cancer, Palliative and Supportive
Care.В 4(10)
McLachlan SA, Clements A, Austoker J. (2012)
Patients’ experiences and reported barriers
toВ colonoscopy in the screening contextaВ systematic review of the literature. Patient
Education and Counselling 86(2):137–46
Michael M, Cullinane C, Hatzamihallis A, O’Kane K,
Milner A, Booth R, Schlicht S, Clarke SJ, FrancisВ P.
(2012) Docetaxel pharmacokinetics and its
correlation with cytochrome P450 probes: The
C14-Erythromcyin breath test versus the antipyrine
clearance test. Cancer Chemother Pharmacol: 69;
125–135.
Moore G, Collins A, Brand C, Gold M, Lethborg C,
Murphy M, Sundararajan V, Philip J (2012) Palliative
and supportive care needs of patients with highgrade glioma and their carers: A systematic review
of qualitative literature, Patient Education and
Counselling, December 4th
Ng SL, Burns WI, Snyder RD, Newnham GM,
McLachlan SA, Liew D, Dowling AJ. (2012) A
retrospective cohort study of metastatic colorectal
cancer patients treated with Oxaliplatin-based
chemotherapy, with an exploratory analysis of
changing serum carcinoembryonic antigen (CEA)
levels. Asia–Pacific Journal of Clinical Oncology
Jun;8(2):172–9,
Ngan SY, Burmeister B, Fisher RJ, Solomon M,
Goldstein D, Joseph D, Ackland SP, Schache D,
McClure B, McLachlan SA, McKendrick J, LeongВ T,
Hartopeanu C, Mackay J. (2012) Randomized trial
of short course radiotherapy versus long course
chemoradiation comparing rates of local recurrence
in patients with T3 rectal cancer. J Clinical Oncology.
Nov 1;30(31):3827–33.
Shum AM, Mahendradatta T, Taylor RJ,В PainterВ AB,
Moore MM, Tsoli M, Tan TC, Clarke SJ, RobertsonВ GR,
Polly P. (2012) Disruption of MEF2C signaling
andВ loss of sarcomeric and mitochondrial integrity
in cancer-induced skeletal muscle wasting. Aging
(Albany), 4(2):133–143.
Tsoli M*, Moore MM*, Burg D, Painter A, TaylorВ A,
Lockie SH, Turner N, Warren A, Cooney G,
OldfieldВ B, Clarke SJ, Robertson G. (2012)
ActivationВ of thermogenesis in brown adipose
tissueВ and dysregulated lipid metabolism associated
with cancer cachexia in mice. Cancer Research
72(17): 4372–82. *denotes equal first authors.
st vincent’s research report 2012
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Oncology
Conference publications
Clay TD, Chua W, Moore MM. An elevated
Neutrophil-Lymphocyte Ratio predicts survival
inВ metastatic non-small-cell lung cancer. Medical
Oncology Group of Australia Annual Scientific
Meeting, Brisbane 2012. (Abstract published in:
Asia-Pacific Journal of Clinical Oncology, 2012;
8(S2): 49.)
Collins, A., Philip, J., Brand, C., Gold, M.,
Bohensky,В M., Lethborg, C., Murphy, M., Moore, G.,
and Sundararajan, V. Utilising Hospital Administrative
Datasets to Identify Patterns of Service Use in
Patients with a Primary Malignant Glioma, 19th
International Congress of Palliative Care, Montreal,
9–12 October, 2012 (Oral Presentation).
Collins, IM, Milne, RL, McLachlan SA, Friedlander,В M,
Birch, KE,Weideman, PC, Hopper, JL Phillips KA. Do
BRCA1 and BRCA2 mutation carriers have anВ earlier
natural menopause than their non-carrier relatives:
A study from the Kathleen Cuningham Foundation
Consortium For Research Into Familial Breast
Cancer (kConFab). San Antonio Breast Cancer
Symposium 2012 (poster presentation)
Devitt B, Philip J, McLachlan SA. Making decisions
and managing dissent in multidisciplinary cancer
meetings (MDMs):a qualitative analysis. Cancer
Care Co-ordinators Conference, 6–10 March, 2012,
Melbourne. (poster presentation)
Devitt B, Philip J, Singh M et al. Patients’
and health professionals’ perspectives on the
outcomes, conduct, and medico-legal implications
of multidisciplinary cancer meetings (MDMs).
JВ ClinВ Oncol 30, 2012 (suppl; abstr e16562)
Devitt B, Philip J, Singh M et al. Patients’ and
health professionals’ perspectives on the outcomes
and conduct of multidisciplinary cancer meetings
(MDMs). Clinical Oncology Society of Australia
ASM, November 13–15, 2012, Brisbane (abstr 762)
(poster presentation)
Devitt B, The development of evidence based
guidelines on the conduct of multidisciplinary
cancerВ meetings (MDMs). A modified Delphi
study. Clinical Oncology Society of Australia
ASM, November 13–15, 2012, Brisbane
(abstrВ 763)В (poster presentation)
Devitt, BA, Philip, J, Singh, MS, Mileshkin, LR,
McLachlan SA. Patients’ and health professionals’
perspectives on the outcomes, conduct, and
medico-legal implications of multidisciplinary
cancerВ meetings (MDMs). J Clin Oncol 30, 2012
(suppl; abstr e16562)
Lethborg C, The Social Determinants of Health
– Cancer, COSA/IPOS Invited Plenary, Brisbane,
November, 2012
Philip, J, Collins, A., Brand, C., Gold, M.,
Murphy,В M., Moore, G., Sundararajan, V.,
andВ Lethborg, C, Understanding the Supportive
and Palliative Care Needs of People with Primary
Malignant Glioma and Their Carers, The IPOS
14th World Congress and Psychosocial Academy,
Brisbane, Australia, 11–15 November 2012
(OralВ Presentation).
Philip, J., Brand, C., Gold, M., Bohensky, M.,
Lethborg, C., Murphy, M., Moore, G., Collins,В A.,
andВ Sundararajan, V. Utilising Hospital Administrative
Datasets to Identify Patterns ofВ Service Use in
Patients with a Primary Malignant Glioma, The IPOS
14th World Congress and Psychosocial Academy,
Brisbane, Australia, 11–15 November 2012
(OralВ Presentation).
Philip, J., Collins, A., Brand, C., Gold, M., Moore,В G.,
Sundararajan, V., Murphy, M., and Lethborg, C.
Understanding the Supportive and Palliative Care
Needs of Patients with Primary Malignant Glioma:
Views of Carers and Health Care Professionals.
World Research Congress of the European
Association of Palliative Care (EAPC), Trondheim
7–9 June 2012 (Oral Presentation).
Philip, J., Gold, M., Brand, C., Lethborg, C.,
Murphy, M., Sundararajan, V., Moore, G.,
Collins.В Understanding the Supportive and
PalliativeВ Care Needs of People with Primary
Malignant Glioma and their Carers, Shaping
theВ Future of Palliative Care Conference, Palliative
Care Victoria, Melbourne, 23–24th August 2012
(OralВ Presentation).
st vincent’s research report 2012
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Oncology
Speaking engagements
Devitt, B., Philip J, Singh M. et al. Patients’ and
health professionals’ perspectives on the outcomes
and conduct of multidisciplinary cancer meetings
(MDMs).’ MOGA ASM, 8–10 August 2012, Brisbane.
Francis, P. Emerging Issues in Supportive Care
Research. 1st International Consensus Guidelines
for Advanced Breast Cancer. ANZBCTG Annual
Scientific Meeting, Hobart, July 2012.
Devitt, B., Philip, J., McLachlan, SA., Health
professionals’ and patients’ attitudes to cancer
multidisciplinary meetings: a qualitative analysis.
Cancer Care Co-ordinators Conference,
6–10 March, 2012, Melbourne.
Lethborg C, �MaP Therapy’ – Invited Presentation,
Social Work Department – Cairns Base Hospital,
May 2012
Lethborg C, “Map Therapy” – Invited Presentation,
Eastern Palliative Care, Victoria, November 2012
Lethborg C, “Supporting blokes” – issues for
partners of women with breast cancer, Invited
Presentation, �Think Pink’ – The Living Centre,
Melbourne – August 2012
Lethborg C, Identifying the underserved
groups in cancer care – core to the social
work role – Invited presentation, Social Work Day,
St Vincent’s Hospital, March, 2012
Lethborg C, Meaning and Suffering – Exploration
Towards The Meaning Of Life, Invited Presentation,
CafГ© Church, Baden Powell Hotel, Collingwood,
MayВ 2012
Lethborg C, Posenelli S, Brock K, Chapman
P, Nandurkar H, Research Week Hypothetical,
St Vincent’s Hospital May 2012
Lethborg C, The underserved cancer patient,
InvitedВ presentation, Social Work Day,
WesternВ Health, March 2012
Lethborg C, Treatment completion, Invited
Presentation for Breast Cancer Network Australia,
remote patient scheme – Cairns, May 2012
st vincent’s research report 2012
148
Orthopaedics
St Vincent’s Department of Orthopaedics
maintains an active clinical and basic science
research program that focuses on three key
areas that are linked with our clinical activity.
These include arthritis care, musculoskeletal
tumours and advanced limb reconstruction.
About us
Arthritis care: Our research explores factors that
affect health and economic outcomes and patient
satisfaction following arthritis surgery. These include
patient, procedural, prosthetic and perioperative
factors. A database of over 8,500 joint replacements
underpins our research and this information informs
our programs of research. Our research into arthritis
surgery is critical for ensuring the best outcomes
forВ patients and that policies and practice are
evidence-based.
Musculoskeletal tumours: Using advanced
imaging techniques, we are investigating the
waysВ that bone tumours grow and spread, and
howВ they can be treated with novel approaches.
TheВ mechanisms we are studying include cell-cell
andВ cell-matrix interactions, the role of quantum
dotsВ in tracking interactions, and theВ use of
megavoltage radiotherapy derived from the
Australian Synchrotron.
Advanced limb reconstruction: Capitalising
onВ advances in polymer science, nanotechnology
and manufacturing, our research is studying how
specially fabricated materials can be used to replace
bone and soft tissues after tumour resection. These
new approaches are looking to develop functional
units of artificial muscles, structural devices from
additive manufacturing (3-D printing, selective laser
melting) and tissue using regenerative and cellular
engineering techniques.
Major projects
Highlights
Our research into arthritis has identified that obesity
and psychological distress are emerging as highly
important but modifiable risk factors for sub-optimal
outcome following total joint replacement. Our
research has led to two world first collaborative
studies commencing in 2012 that are assessing
theВ potential to improve outcomes in these groups.
• The Arthroplasty and Bariatric Surgery
Study: Knee replacement is a common surgical
procedure in Australia (46,000 per year). More
than 60% of this group are obese and this is
associated with higher early (clinical) and long term
(implant) survival complications. Laparoscopic
adjustable gastric banding (LAGB) is an effective
and safe means of achieving sustained weight
loss. This study compares the outcomes of total
knee replacement in groups of severely obese
patients who have and have not undergone preknee replacement LAGB.
• Mindfulness, cognitive processes and
copingВ in chronic illness: insights from
aВ studyВ of joint replacement surgery:
ThisВ studyВ investigates whether participation
in aВ mental health enhancement program
(mindfulness) with will improve the recovery
ofВ patients undergoing total joint replacement.
ThisВ will benefit patients by promoting psychological
well-being which has direct effects on pain and
physical function after surgery.
Our research into musculoskeletal tumours has
beenВ selected as one of the key areas for research
at the Australian Synchrotron. This collaboration
will allow us to undertake research that utilises the
power of the synchrotron to provide high-resolution
images of tumours and the way in which they may
interact with bone. Specially focused beams of
radiation are also being used to test new ways
ofВ treating bone tumours that may not be able
toВ beВ removed by surgery alone.
• Investigation of the tumour-to-bone interface
in osteosarcoma. Work performed on Imaging
and Medical Beamline: Project IM5234; Beam
time 23–26 Nov 2012. Osteogenic sarcomas
are invasive tumours that infiltrate and destroy
bone causing high morbidity for patients. A key
aim of this study has been to improve imaging
of the tumour and the tumour-to-bone interface.
This beam time on the IMBL has produced high
resolution 3-dimensional images of primary tumour
to clearly depict how the tumour cells interact with
the bone and with excellent definition of the lytic
effects on bone. This information is being used for
design of a study in which microbeam radiation
therapy (MRT) will be tested at the Australian
Synchrotron for the treatment of aggressive
sarcoma tumours.
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• Quantum dots: Novel fluorescent probes shed
light on bone disease and tumour progression.
In this project, novel coupling chemistry is being
used to label a ligand, calcitonin that binds the
calcitonin receptor present on bone lytic cells
called osteoclasts. Calcitonin is a regulatory
hormone that mediates bone formation and
thisВ capacity to label these highly active cells in
bone will provide information on the physiological
role of CT as well as enable the �tracking’ of
these important cells in our in vitro and in vivo
experiments when studying tumours of bone
andВ other bone diseases.
Our research into advanced limb reconstruction
hasВ seen the development of a national
collaboration between St Vincent’s Hospital,
University of Melbourne, University of Wollongong,
Royal Melbourne Institute of Technology and the
Queensland University of Technology. This capitalises
on specialised capabilities from the fields of polymer
research, advanced materials manufacturing,
tissue engineering and surgery. Research projects
include the regeneration of cartilage using stem
cell techniques on specially designed structures,
studying how nerves can be stimulated to grow
and attach to artificial surfaces, the development
ofВ metallic structures from advanced manufacturing
techniques to fill bone defects and the role of
electrochemical polymers as materials to mimic
theВ action of muscles. These studies form one
ofВ theВ many facets of bioengineering research
ofВ theВ ACMD group.
• Optimizing neuromuscular junctions for direct
nerve to muscle neurotisation. The aim of
this project is to improve outcomes for patients
with neuromuscular dysfunction after injury or
surgery. Muscle reinnervation, called neurotisation,
is being studied using in vitro modelling in
neuronal cell-muscle cell co-cultures; the focus
is to improve neuromuscular junction formation
using pre-patterning of receptor expression
andВ bioengineering techniques.
• Electrochemical materials as muscle substitutes.
This project is studying the possibility of replacing
injured muscle with synthetic material that can be
actuated by electrical impulses to alter their shape
thereby producing contractions. This may be useful
for people who have suffered stroke, partialВ muscle
loss or sphincter disturbance.
Projects
• The Arthroplasty and Bariatric Surgery (ABS)
Study: a randomised controlled trial ofВ laparoscopic
adjustable gastric banding priorВ toВ total knee
arthroplasty (2012–2015)
• Mindfulness and coping in chronic illness:
insightsВ from a study of joint replacement
surgery (2012–2014)
• Evaluating the impact of obesity on knee load
over time in those who have undergone optimal
surgical re-alignment after total knee replacement
(2012–2014)
• Examining psychological state in patients presenting
for arthritis surgery (2012–2015)
• Regeneration of cartilage in chondral and
osteochondral defects. In this project we have
devised a novel approach for regeneration of
cartilage defects and osteochondral defects.
OurВ approach combines the use of chondrocyte
stem/progenitor cells in combination with
aВ biosynthetic or biological matrix.
• A pilot study investigating dietetic weight loss
interventions and 12-month functional outcomes
ofВ patients undergoing knee or hip surgery
• Investigation of surface nanostructured
titanium alloys for prosthetic devices. The
Department of Mechanical Engineering through
the School of Engineering at the University
of Melbourne manufacture different titanium
alloys with nanostructured surface properties.
Biocompatibility studies are being conducted
toВ determine appropriate substrates for growth
ofВ cells with the aim to improve biocompatibility
ofВ metals used for prosthetic devices.
• Studying the differences in nuclear tracers
forВ targeting bone metastases.
• A prospective, single-arm, uncontrolled, multicentre study to evaluate the safety and efficacy
ofВ the DePuy AVN Cage prosthesis for the treatment
of avascular necrosis of the hip.
• Studying the impact of poorly performed community
surgery on the outcomes of patientsВ with
musculoskeletal tumours.
• Studying the development of cartilage tissue
fromВ stem cells.
• Studying the efficacy of conducting polymers
asВ artificial muscles.
• Studying the molecular factors that regulate
theВ development of neural synapses.
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Awards
Basic Science Research
• Dr Michelle Dowsey – National Health and
Medical Research Council – Early Career
Australian Clinical Fellowship
A/Prof Damian Myers, Head Basic Research,
1.0В EFT
• Dr Michelle Dowsey – Australian Rheumatology
Association Victorian Branch Inaugural Annual
Scientific Meeting – Best Abstract and Oral
Presentation 2012 for �Associations between preoperative radiographic changes and outcomes
after total knee joint replacement for osteoarthritis’
• Dr Trisha Peel – National health and Medical
Research Council – Scholarship
Dr Alyson Croxford, Research Fellow
(January–June 2012); 0.4FTE
Ms Shalley Robins, Research Assistant
(December 2012); 0.8FTE
Dr. Claudia Di Bella, Orthopaedic Fellow 0.2 EFT
Students
Dr Sina Babazadeh, PhD Candidate
• Dr Ken Ye – National Health and Medical
Research Council – Scholarship
Dr Trisha Peel, PhD Candidate
• Dr Bill Zhang – National Health and Medical
Research Council – Scholarship
Ms Katherine Carroll, Honours
Quality
Dr Ken Ye, PhD Candidate
As a result of our current research initiatives into
obesity we have established a dietetic service
inВ the Orthopaedic pre-admission clinic and have
commenced evaluating the impact of this service
onВ patient outcomes in those undergoing knee
orВ hip surgery
Dr Bill Zhang, PhD Candidate
Dr John Swan, Masters Candidate
Dr Matthew Broadhead, PhD Candidate
Mr Raed Salimban, PhD Candidate
Ms Anneke Ryan (2nd year) jointly with Bio21,
SchoolВ of Chemistry, PhD Candidate
Mr Hugh Buzacot, Honours
Our research into infection after total joint
replacement has informed the development for
guidelines to treat acute prosthetic joint infections.
Theses passed in 2012
Staff
Mr Hugh Buzacot, Honours, University of Melbourne
Prof Peter Choong, Director of Orthopaedics,
1.0В EFT
Service to the wider community
Arthritis Research
Dr Michelle Dowsey, Head Arthritis Research,
0.5В EFT
Ms Deborah May, Sarcoma Research Co-ordinator,
0.4 EFT
Ms Jane Keenan, Research Co-ordinator, 0.3 EFT
(From February 2012)
Ms Angela Cochrane, Research Co-ordinator,
0.9В EFT (From May 2012)
Dr Elizabeth Nelson, Research Associate (Honorary)
(From May 2012)
Mr James Stoney, Consultant Orthopaedic
SurgeonВ (Honorary)
Ms Katherine Carroll, Honours,
UniversityВ ofВ NotreВ Dame
Prof Peter Choong
• President Asia Pacific Musculoskeletal
TumourВ Society
• Co-Chair Victorian Orthopaedic Research
TrustВ Scientific Advisory committee
• President-elect, Australian
OrthopaedicВ Association
• President-elect, Asia Pacific Computer
assistedВ Orthopaedic Surgery Group
• Chair, Constitutional Review Committee, AOA
• Chair, Specialty Societies Committee, AOA
• Editor, Section of Orthopaedics, ANZJSurgery
• Review College, JBJS, CORR, JArthroplasty,
JВ Orth Sci, J Orth Surg, MJA, Cancer
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Orthopaedics
• Member, Faculty Advisory Committee, Faculty
of Medicine, Denstistry and Health Science,
University of Melbourne
• Member, Melbourne Medical School Planning
andВ Policy Committee
• Member, Medical Executive Committee,
St Vincent’s Hospital
• Member, Medical Advisory Group,
St.Vincent’s Hospital
• Member, Electoral College, St Vincent’s hospital
• Director, Board of Genezzano FCJ College
Dr Michelle Dowsey
• Member, St Vincent’s Hospital Human
Research Ethics Committee – A
A/Prof Damian Myers
• 1st Asia-Pacific Advanced Medical Imaging
Workshop, ANZBMS 2012
• Co-Convenor Satellite meeting of the 1st AsiaPacific Bone and Mineral Research Meeting;
heldВ in conjunction with the 22nd ANZBMS
Annual Scientific Meeting; 2–5 September 2012
• Plenary Speaker: Quantitative imaging of skeletal
tissues & structures: challenges at the frontier
• Beamline Advisory Panel, Imaging and Medical
Beamline, Australian Synchrotron
• Responsible Investigator, Project 1.2 of CRC
forВ Biomedical Imaging Development
• International Reader, Australian Research Council
• Chair (Inaugural) of Ethics Committee
atВ theВ Australian Synchrotron
• Assigned as Project Leader, �Bone Studies’,
IMBLВ at Australian Synchrotron
• AINSE Committee, Biomedical Sciences
andВ Biotechnology, ANSTO
• Project Consultant, CRC for Biomedical
ImagingВ Development
• Member of Research Week Committee,
St Vincent’s Hospital
• Member of St Vincent’s Hospital
�Research Technology Group’
• Assigned as Head of Imaging Project under the
Musculoskeletal Theme of the Clinical Programme
of the IMBL at the Australian Synchrotron
• Scholarships Committee Member for the
VictorianВ Comprehensive Cancer Centre
• Director, Advanced Microscopy Imaging Facility,
St Vincent’s Hospital
• Seminar to the Rotary Club of Balwyn
Grants
Choong PFM, Castle DJ, Salzberg MR, Dowsey
MM, Knowles SR, Monshat K
Mindfulness and coping in chronic illness: insights
from a study of joint replacement surgery,
AustralianВ Research Council
$270,445 for 2012–2014 ($84,149 in 2012)
Choong PFM, Bennell KL, Wrigley T, Hinman R,
Dowsey MM
Evaluating the impact of obesity on knee load
over time in those who have undergone optimal
surgical re-alignment after total knee replacement,
AustralianВ Research Council
$706,196 for 2012–2014 ($235,400 in 2012)
Choong PFM, Brown, WA, Liew D, Dowsey MM
The Arthroplasty and Bariatric Surgery (ABS)
Study: a randomised controlled trial of laparoscopic
adjustable gastric banding prior to total knee
arthroplasty, National Health and Medical
ResearchВ Council
$643,668 for 4 years ($275,293 in 2012)
Dowsey, MM
Examining psychological state in patients presenting
for arthritis surgery, National Health and Medical
Research Council
$294,892 for 2012–2015 ($73,723 in 2012)
Peel, TN
Epidemiology, Diagnosis, Treatment and Costs
ofВ Orthopaedic Infections, National Health and
Medical Research Council
$72,000 for 2011–2012 ($36,000 in 2012)
Simmance N, Gandler N, Dowsey MM,
ChoongВ PFM
A pilot study investigating dietetic weight
lossВ interventions and 12-month functional
outcomes of patients undergoing knee or hip
surgeryВ in theВ Elective Surgery Access Service,
St. Vincent’s Hospital Research Endowment Fund
$22,907 for 2012
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Choong, PFM
A prospective, single-arm, uncontrolled, multicentre study to evaluate the safety and efficacy
ofВ the DePuy AVN Cage prosthesis for the
treatmentВ ofВ avascular necrosis of the hip,
JohnsonВ & Johnson Medical P/L
$235,861 for 2011–2015 ($26,756 in 2012)
Choong PFM, Pandy M, Wallace, G.
Building Artificial Muscle for Limb Reconstruction
after Tumour Surgery, Australian Orthopaedic
Association
$50,000 in 2012
Hutmacher, D, Schuetz, M, Epari, D,
Woodruff,В M, Dickinson, I, Choong, P, Steck, R,
Bioactive and biodegradable scaffold and novel graft
source for the repair of large segmental defects,
NHMRC
$440,902 for 2013–2015
DE Myers, PF Choong, M Broadhead
Suppression of osteosarcoma tumour
invasionВ andВ metastasis: Monitoring therapeutic
outcomes using advanced imaging techniques,
Xavier KrikoriВ Sarcoma Research Grant,
AustralianВ Sarcoma Group
$25,000 for 2011–2012 ($12,500 in 2012)
Prof PFM Choong, A/Prof DE Myers,
ProfВ GGВ Wallace, Dr C Di Bella
Rebuilding the bone-cartilage interface,
AustralianВ Orthopaedic Association
$53,000 for 2011–2012 ($26,500 in 2012)
Prof Kenong Xia, Prof. Peter Choong,
A/Prof.В Damian Myers, Dr Wei Xu
Limb engineering for future regenerative implants,
MERIT Grant, University of Melbourne
$25,000 for 2011–2012 ($12,500 in 2012)
A/Prof DE Myers, Prof RJ Hicks, Prof PFM
Choong, Dr AW Stevenson, Dr D Häusermann
Investigation of tumour invasion of bone using
advanced imaging including synchrotron radiation,
CASS Foundation Grant
$50,000 for 2011–2012 ($25,000 in 2012)
Prof Mark Cook, Prof Peter Choong,
A/Prof Damian Myers and others With
support from the St Vincent’s Foundation
Equipment grants for Advanced Microscopy Imaging
Facility, Ian Potter Foundation ($65,000), Rowden
White Foundation ($110,000), Rotary Club of Balwyn
($50,000) Plus other grants
Two microscope purchases: 1. Nikon A1Rsi confocal
microscope (Approx $600,000); 2. Live-cell imaging
system – Nikon FN1 upright fixed-stage microscope
(Approx $340,000)
Collaborations in research
International
• Professor Stefan Lohmander, Department
ofВ Orthopaedics, University of Lund, Sweden
• Professor Paul Dieppe, St. Peter’s College, Oxford
University, United Kingdom
• Université Joseph Fourier, Centre de Recherche
Inserm and ESRF, France
• CHU Bicêtre, UNCE, Dept of Neurophysiology
andВ Epilepsy, Paris, France
National
• Prof David Castle, Department of Psychiatry,
University of Melbourne, St. Vincent’s Hospital
• Prof Peter Brooks, Australian Health Workforce
Institute, University of Melbourne
• Prof Kim Bennell, Department of Physiotherapy,
University of Melbourne
• Prof Danny Liew, Department of Medicine,
University of Melbourne, Royal Melbourne Hospital
• Prof Jane Gunn, Department of General Practice,
University of Melbourne
• A/Prof Wendy Brown, Centre for Obesity
ResearchВ and Education, Monash University
• Dr Simon Knowles, Faculty of Life and Social
Sciences, Swinburne University
• Prof Marcus Pandy, Department of Mechanical
Engineering, University of Melbourne
• Ms Natalie Simmance, Aged Care & Allied Health
Nutrition, St. Vincent’s Hospital
• Prof Gordon Wallace, Intelligent Polymer Research
Institute, University of Wollongong
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• Prof Marcus Pandy, Prof Kenong Xia, A/Prof
Vincent Lee, Department of bioengineering and
mechanical engineering, University of Wollongong
• Prof Milan Brandt, School of Aerospace,
Mechanical and Manufacturing Engineering,
RMITВ University
• Prof Dietmar Hutmacher, Science and Engineering
Faculty, Queensland University of Technology
• Prof Paul Mulvaney, Bio21, School of Chemistry,
University of Melbourne, Parkville, Victoria
• Prof Rodney Hicks, Peter MacCallum Cancer
Centre, Melbourne
• Prof Daniel Hausermann, Australian Synchrotron,
Clayton Victoria
• Prof Andrew Stevenson, X-Ray Physics
andВ Instrumentation Laboratory, CSIRO,
Clayton,В Victoria
Publications
Book chapters
Dowsey M.M., Peel T.N., Choong, P.F.M. Infection
in primary hip and knee arthroplasty. In Infection
in Primary Hip and Knee Arthroplasty, Recent
Advances in Arthroplasty, Samo K. Fokter (Ed.),
ISBN: 978–953–307–990–5, InTech, Available from:
www.intechopen.com/articles/show/title/infection-inprimary-hip-and-knee-arthroplasty
Journal articles
Babazadeh S, Dowsey MM, Stone JD, Choong PF.
The accuracy of retrospectively measured range of
motion in knee arthroplasty. Acta Orthop Belg. 2012
Dec;78(6):751–6. PubMed PMID: 23409571.
Choong P. Soft tissue sarcoma: new paradigms
in care. Sarcoma. 2012;2012:439208. doi:
10.1155/2012/439208. Epub 2012 Dec 31.
PubMed PMID: 23346011; PubMed Central
PMCID:В PMC3549354.
Shkolnikova J, Flynn J, Choong P. Burden
ofВ bisphosphonate-associated femoral fractures.
ANZ J Surg. 2013 Mar;83(3):175–81. doi: 10.1111/
ans.12018. Epub 2012 Dec 6. PubMed PMID:
23216704.
Peel TN, Buising KL, Dowsey MM, Aboltins CA,
Daffy JR, Stanley PA, Choong PF. Outcome
ofВ debridement and retention in prosthetic joint
infections by methicillin-resistant staphylococci,
with special reference to rifampin and fusidic acid
combination therapy. Antimicrob Agents Chemother.
2013 Jan;57(1):350–5. doi: 10.1128/AAC.02061–
12. Epub 2012 Oct 31. PubMed PMID: 23114758;
PubMed Central PMCID: PMC3535910.
Babazadeh S, Dowsey MM, Stoney JD, Choong PF.
The effect of tibio-femoral over-distraction in primary
knee arthroplasty. Knee Surg Sports Traumatol
Arthrosc. 2012 Oct 21. [Epub ahead of print]
PubMed PMID: 23085821.
Peel TN, Cheng AC, Choong PF, Buising KL.
Early onset prosthetic hip and knee joint infection:
treatment and outcomes in Victoria, Australia. J
Hosp Infect. 2012 Dec;82(4):248–53. doi: 10.1016/j.
jhin.2012.09.005. Epub 2012 Oct 22. PubMed
PMID: 23084482.
Qi SD, Smith PD, Choong PF. Nuclear reprogramming
and induced pluripotent stem cells: a review
for surgeons. ANZ J Surg. 2012 Oct 4. doi:
10.1111/j.1445–2197.2012.06282.x. [Epub
aheadВ ofВ print] PubMed PMID: 23035845.
Grinsell D, Di Bella C, Choong PF. Functional
reconstruction of sarcoma defects utilising
innervated free flaps. Sarcoma. 2012;2012:315190.
doi: 10.1155/2012/315190. Epub 2012 Aug 28.
PubMed PMID: 22969309; PubMed Central PMCID:
PMC3434415.
Tang MH, Pan DJ, Castle DJ, Choong PF.
AВ systematic review of the recent quality
of life studies in adult extremity sarcoma
survivors. Sarcoma. 2012;2012:171342. doi:
10.1155/2012/171342. Epub 2012 Aug 23.
PubMed PMID: 22966215; PubMed Central
PMCID:В PMC3432553.
Peel TN, Buising KL, Choong PF. Diagnosis and
management of prosthetic joint infection. Curr Opin
Infect Dis. 2012 Dec;25(6):670–6. doi: 10.1097/
QCO.0b013e32835915db. PubMed PMID:
22964949.
Alford S, Choong P, Chander S, Henderson M,
Powell G, Ngan S. Outcomes of preoperative
radiotherapy and resection of retroperitoneal
sarcoma. ANZ J Surg. 2012 Sep 3. doi:
10.1111/j.1445–2197.2012.06211.x. [Epub
aheadВ ofВ print] PubMed PMID: 22943678.
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Babazadeh S, Dowsey MM, Bingham RJ, Ek ET,
Stoney JD, Choong PF. The long leg radiograph
is a reliable method of assessing alignment when
compared to computer-assisted navigation and
computer tomography. Knee. 2012 Aug 11.
[EpubВ ahead of print] PubMed PMID: 22892197.
Huang NF, Dowsey MM, Ee E, Stoney JD,
Babazadeh S, Choong PF. Coronal alignment
correlates with outcome after total knee arthroplasty:
five-year follow-up of a randomized controlled
trial. J Arthroplasty. 2012 Oct;27(9):1737–41.
doi:В 10.1016/j.arth.2012.03.058. Epub 2012
AugВ 3.В PubMed PMID: 22868073.
Dowsey MM, Nikpour M, Dieppe P, ChoongВ PF.
Associations between pre-operative radiographic
changes and outcomes after total knee joint
replacement for osteoarthritis. Osteoarthritis
Cartilage. 2012 Oct;20(10):1095-102. doi:
10.1016/j.joca.2012.05.015. Epub 2012
JulВ 16.В PubMed PMID: 22800770.
Choong P, Brooks P. Achievements during the
Bone and Joint Decade 2000–2010. Best Pract
Res Clin Rheumatol. 2012 Apr;26(2):173–81.
doi:В 10.1016/j.berh.2012.03.004. PubMed
PMID:В 22794093.
Broadhead ML, Choong PF, Dass CR. Efficacy
of continuously administered PEDF-derived
synthetic peptides against osteosarcoma
growth and metastasis. J Biomed Biotechnol.
2012;2012:230298. doi: 10.1155/2012/230298.
Epub 2012 May 30. PubMed PMID: 22701300;
PubMed Central PMCID: PMC3369529.
Choong PF. Comminuted radial head fractures:
picking up the pieces. ANZ J Surg. 2012
Jun;82(6):385–6. doi: 10.1111/j.1445–
2197.2012.06100.x. PubMed PMID: 22672393.
Choong PF. Tourniquet use in knee replacement
surgery: what is the evidence? ANZ J Surg.
2012 Jun;82(6):384–5. doi: 10.1111/j.1445–
2197.2012.06099.x. PubMed PMID: 22672392.
Dowsey MM, Dieppe P, Lohmander S, Castle D,
Liew D, Choong PF. The association between
radiographic severity and pre-operative function
inВ patients undergoing primary knee replacement
for osteoarthritis. Knee. 2012 Dec;19(6):860–5.
doi:В 10.1016/j.knee.2012.02.007. Epub 2012
MarВ 23. PubMed PMID: 22445613.
Peel TN, Cheng AC, Buising KL, ChoongВ PF.
Microbiological aetiology, epidemiology,
andВ clinical profile of prosthetic joint infections:
are current antibiotic prophylaxis guidelines
effective? Antimicrob Agents Chemother. 2012
May;56(5):2386–91. doi: 10.1128/AAC.06246–11.
Epub 2012 Feb 6. PubMed PMID: 22314530;
PubMed Central PMCID: PMC3346661.
Peel TN, Dowsey MM, Buising KL, Liew D,
ChoongВ PF. Cost analysis of debridement and
retention for management of prosthetic joint
infection. Clin Microbiol Infect. 2013 Feb;19(2):181–6.
doi: 10.1111/j.1469–0691.2011.03758.x. Epub
2012 Jan 20. PubMed PMID: 22264335.
Alford S, Choong P, Chander S, Henderson M,
ChuВ J, Powell G, Williams S, Ngan S. Value of
PET scan in patients with retroperitoneal sarcoma
treated with preoperative radiotherapy. Eur J Surg
Oncol. 2012 Feb;38(2):176–80. doi: 10.1016/j.
ejso.2011.11.001. Epub 2011 Dec 9. PubMed
PMID: 22154883.
Conference publications
Annual Scientific Meeting of the AmericanCollege-of-Rheumatology (ACR) and Associationof-Rheumatology-Health-Professionals (ARHP)
Location: Washington, DC Date: NOV 09–14, 2012
Le Marshall, K. F.; Yee, B.; Dieppe, P. A.; Leung,В A.;
Page, C.; Choong, P. F.; Dowsey, M.; Lim, K. K.
Differences Between Patients with Hip and Knee
Osteoarthritis. Arthritis and Rheumatism. 2012 Oct,
64(10); S117
Crowley C, Dowsey MM, Quinn C, Barrington M,
Choong PF. Impact of regional and local anaesthetics
on length of stay in knee arthroplasty. ANZ J Surg.
2012 Apr;82(4):207–14. doi: 10.1111/j.1445–
2197.2011.05991.x. Epub 2012 Feb 3. Review.
PubMed PMID: 22510175.
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Speaking engagements
Choong PF. Evidence for surgery in pelvic Ewing’s
– How robust is it. 85th Annual Scientific Meeting
of theВ Japanese Orthopaedic Association, Kyoto,
Japan, 15–17 May 2012
Choong PF. Surgery for Ewing’s of the Pelvis –
WhatВ is the evidence? 1st Oriental Orthopaedic
Congress, Shanghai, China July 27–29, 2012
Choong PF. Margins for soft tissue sarcoma –
How close can you go? 1st Oriental Orthopaedic
Congress, Shanghai, China July 27–29, 2012
Choong PF. Megaprostheses – Lessons Learnt.
1stВ Oriental Orthopaedic Congress, Shanghai,
China July 27–29, 2012
Choong PF. Osteoarthritis – The challenge of
surgical management. Bill Wheeler Symposium,
Intelligent Polymer Research Institute,
UniversityВ ofВ Wollongong, August 6, 2012
Choong PF. Complications and its prevention in
metastatic surgery. 9th Asio-Pacific Musculoskeletal
Tumour Society Meeting, Kuala Lumpur, Malaysia,
September 8, 2012
Choong PF. Resection and reconstruction for
giant cell tumour – the debate. 9th Asio-Pacific
Musculoskeletal Tumour Society Meeting, Kuala
Lumpur, Malaysia, September 8, 2012
Choong PF. The challenges of academic surgery
in the new millennium. Prince Charles Hospital
Research Week. Brisbane, October 15–16, 2012
Choong PF, Peel T. Buising K, Cheng A. Outcome
of patients with methicillin resistant staphylococcal
infections managed with debridement and retention
of the prosthesis. Annual Scientific Meeting of
the Arthroplasty Society of Australia. Melbourne
May 30 – June 2, 2012
Dowsey, MM, Nikpour M, Dieppe P, ChoongВ PFM
– Associations between pre-operative radiographic
changes and outcomes after total knee joint
replacement for osteoarthritis Australian
Rheumatology Association Annual Scientific
MeetingВ Oct 2012:, Melbourne
Peel T, Buising K, Cheng A, Choong P, The
Microbiological Aetiology, Epidemiology and
ClinicalВ Profile of Prosthetic Joint Infections: are
current antibiotic prophylaxis guidelines effective?
22nd ECCMID 2012 April 2012; United Kingdom
Broadhead ML, Myers DE, Choong PFM. Applying
advanced imaging techniques to a murine model
ofВ orthotopic osteosarcoma for the evaluation of
PEDF therapy. Australian Orthopaedic Association
Annual Scientific Congress, October 2012
Broadhead ML, Myers DE, Choong PFM The
application of in vivo bioluminescent imaging,
PETВ and micro-CT to a murine model of orthotopic
osteosarcoma. Australasian Sarcoma Study Group
Annual Meeting, Sydney, October 2012
Ye K, Felimban R, Di Bella C, Crook J, Quigley A,
Kapsa R, Choong P, Myers DE. Chondrogenesis
ofВ adipose stem cells derived from infrapatellar
fatВ pad Australian Orthopaedic Association,
AnnualВ General Meting, Lorne, 24th Feb 2012
DE Myers, R Felimban, K Ye, C Di Bella, J Foroughi,
J Chung, SE Moulton, A Quigley, J Crook, R
Kapsa, GG Wallace and PFM Choong. 3rd AsiaPacific Bionics Meeting, Production of hyaline
cartilage inВ 3D chitosan scaffolds using infrapatellar
fat padВ stem cells as the source of chondrocyte
lineageВ cells, September 2012
Choong PF, Dowsey MM, Huang N, Stoney J.
Does the correlation between coronal alignment,
knee function and pain continue ? Annual Scientific
Meeting of the Arthroplasty Society of Australia.
Melbourne May 30 – June 2, 2012
Choong PF, Dowsey MM. The economic burden
ofВ obesity in total knee replacement. Annual
Scientific Meeting of the Arthroplasty Society
of Australia. Melbourne May 30 – June 2, 2012
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Podiatry
St Vincent’s Podiatry Department treats
medicalВ conditions of the lower limb and
footВ withВ a primary focus on the acute
high-riskВ foot and diabetes.
About us
The Podiatry Department aim to improve patient
treatment outcomes by implementing current best
practice and working towards establishing universal
podiatry treatment guidelines across all of podiatry
toВ improve practice within the profession.
Major projects
No research was conducted in 2012
Staff
The podiatry department does not currently
employВ any research staff.
Theses passed in 2012
Casie Barrette, Graduate Diploma in Wound Care,
Monash University
Service to the wider community
• Tracy Davis, Board Member,
AustralianВ PodiatryВ Association (VIC)
• Tracy Davis, Scientific Committee,
StateВ PodiatryВ Association (VIC)
Grants
No research grants received in 2012/2013.
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Rehabilitation
Research in rehabilitation at St Vincent’s is
focused on collaborative research, both between
disciplines within St Vincent’s Hospital and with
other rehabilitation providers. Key areas of focus
are access to rehabilitation, goal setting and
interventions to improve long-term outcomes.
About us
The Rehabilitation Service at St Vincent’s provides
patient centred and comprehensive care through
ourВ two inpatient rehabilitation units in Fitzroy
andВ Kew. The Fitzroy unit, which is co-located
with the acute services, provides a wide spectrum
of rehabilitation services, including those with
neurological diagnoses such as stroke, multiple
sclerosis and incomplete spinal cord pathologies
and those with musculoskeletal diagnoses such
as fractures, joint replacements and lower limb
amputation. The Rehabilitation Unit at St George’s
isВ co-located with the community rehabilitation
services and provides neurological, orthopaedic
andВ medical rehabilitation. Best practice in
rehabilitation requires an interdisciplinary team
approach. Our research activities reflect this, with
each project developed and progressed by teams
drawn from across the health service. Rehabilitation
for stroke is a key area of research interest, with
wide ranging research activities, including the
selection process for rehabilitation and longer
term interventions aimed at improving community
integration in the first year after stroke.
We have completed a three year randomised
controlled trial investigating recovery during the
first year after stroke. This study demonstrated that
rehabilitation interventions assisting stroke survivors
to achieve their own goals are effective in reducing
post stroke depression. We are also exploring the
efficacy of interventions to improve recovery of arm
movement post stroke and maintaining mobility and
balance in people with multiple sclerosis.
Quality
In stroke care, staff of the St Vincent’s Rehabilitation
Unit have played lead roles in the development
ofВ a Chronic Stroke Resource Kit, auspiced by
theВ Victorian Clinical Stroke Network. The purpose
of this kit is to provide community rehabilitation
clinicians with evidence based assessment and
intervention guidelines to enhance outcomes for
people with chronic stroke and their carers. The
keyВ focus of the kit is on assisting stroke survivors
and their carers to achieve their own personal goals.
The research conducted by our department into
the first year after stroke informed the direction
andВ framework of the kit.
Staff
Dr Kim Brock, Physiotherapist/ Research
Co-ordinator 0.1EFT
Susie Black, Physiotherapist, Research 0.1EFT
Dr Irina Churilov, Rehabilitation Physician 0.05 EFT
Major projects
Students
Goal setting in rehabilitation has been a focus
ofВ research for our unit for several years, both
in theВ inpatient rehabilitation setting and in
the community. We have previously published
work demonstrating the relationship between
achievement f short-term goals and outcomes.
We are currently exploring whether short-term
goal achievement isВ aВ more responsive measure
ofВ ongoing improvement in rehabilitation compared
to theВ goldВ standard rehabilitation measure, the
Functional Independence Measure.
Christine Graven, PhD Student
Robert Mehan, Masters by Research Student
Theses passed in 2012
Robert Mehan, Master of Exercise Science
(Research), Australian Catholic University
Service to the wider community
• Kim Brock, Member of Executive Committee,
International Bobath Instructor Training
Association, The Netherlands
• Meg Mackenzie, Nursing representative for
theВ Victorian Sub Acute Care Stroke Network
atВ the Department of Health.
st vincent’s research report 2012
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Rehabilitation
Grants
Publications
Paul Ilett, Kim Brock, Dr. Ross Clark (Melb
Uni), Melissa Thompson, Janine Simondson,
RobВ Mehan, Dr Irina Churilov
What is the relationship between improvement
inВ gait and balance ability and changes in symmetry
between the hemiplegic and nonhemiplegic
lower limb in the recovery phase post stroke?
St Vincent’s Hospital Research Endowment Fund
$11,498 for 2011–2012 ($2,000 in 2012)
Journal articles
Kim Brock, Christine Graven, Melissa Thompson,
Dominique Cadilhac, Tara Purvis
Chronic Stroke Resource Kit, Victorian Stroke
Clinical Network, Department of Health, Victoria
$19,800 for 2012–2013 ($4,000 in 2012)
Brock K, Luke C, Galea M, Miller K
Improving outcomes for the upper limb in
severeВ stroke: the efficacy of rehabilitation
interventions based on the Bobath Concept,
National Stroke Foundation
$20,000 for 2010–2013 ($5,000 in 2012)
Kennedy GM, Brock KA, Lunt AW, Black SJ. (2012).
Factors influencing selection for rehabilitation after
stroke: A questionnaire using case scenarios to
investigate physician perspectives and level of
agreement. Arch Phys Med Rehabil 93(8):1457–9
Speaking engagements
Robert Mehan. A preliminary study into the use
of ankle foot orthosis in the early stages of stroke
recovery. World Congress for NeuroRehabilitation,
Melbourne, May 2012
Christine Graven. Factors shaping the concept
ofВ recovery post-stroke. Smart Strokes Conference,
Sydney, August 2012
Collaborations in research
National
• University of Melbourne, Parkville, Victoria
• Curtin University, Perth, West Australia
• Australian Catholic University, Fitzroy, Victoria
• Victorian Stroke Clinical Network,
DepartmentВ ofВ Health, Victoria
• Western Health, Sunshine, Victoria
• Cairns Base Hospital, Cairns, Queensland
• Florey Neuroscience Institutes,
Heidelberg,В Melbourne
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Respiratory Medicine
About us
Lung Cancer: Our Department is involved in
aВ number of local and international collaborations
focused on translation of basic research into clinical
care. One of our strengths is the development
ofВ systems that facilitates the gathering of clinical
dateВ to annotate tissue specimens. Using these
linkages to external databases the Department
has been able to participate in in the “Lung Cancer
Genome Project” based in Cologne, Germany,
inВ addition to two major local initiatives: the
“Lung Cancer Research Collaboration” funded
byВ the Victorian Cancer Agency and the Victorian
Lung Cancer Registry.
Sleep Medicine: The department has a focus
onВ conducting clinical research projects in sleep
apnoea and sleep health. We are also collaborating
with national organisations to determine the impact
of improved diabetes control on sleep quality.
Alpa-1-antitrypsin deficiency program:
OurВ department continues to host a register
ofВ patients with this inherited deficiency which
causes premature emphysema and to be involved
inВ trials ofВ alpha-1-antitrypsin replacement therapy.
Major projects
• A Randomised, Placebo-Controlled, DoubleBlind, Multi-centre Phase III/IV Study to compare
the Efficacy and Safety of 60 mg/kg body weight
ofВ Zemaira В® weekly i.v. administration with
Placebo weekly i.v. administration in Chronic
Augmentation and Maintenance Therapy in
Subjects with Emphysema due to Alpha1Proteinase Inhibitor Deficiency.
Investigators: Dr Jonathan Burdon, DrВ DavidВ Hart,
Dr Andrew Kyoong, Dr Matthew Conron,
MrsВ SueВ Brenton, Ms Tamara Matthews
andВ MrВ Cameron Stewart
Sponsor: CSL Behring
Study completed July 2012 –
anticipatedВ publicationВ mid 2013
• An open, non-controlled, multi-centre, multinational
Study to Evaluate the Efficacy and Safety of
ZemairaВ® administration in Chronic Augmentation
and Maintenance Therapy in Subjects with
Emphysema due to Alpha1- Proteinase Inhibitor
Deficiency who completed Clinical Study
CE1226_4001
Investigators: Dr David Hart, Dr AndrewВ Kyoong,
Dr Matthew Conron, Mrs Sue Brenton,
MsВ TamaraВ Matthews and Mr Cameron Stewart
Sponsor: CSL Behring
Study ongoing – anticipated completion
dateВ JulyВ 2014
• A randomised, double-blind, 12-week treatment,
parallel-group study to evaluate the efficacy and
safety of QMF149 (150 Вµg/160 Вµg o.d.) compared
with salmeterol xinafoate/fluticasone propionate
(50В Вµg/500 Вµg b.i.d.) in patients with chronic
obstructive pulmonary disease
(Sponsor: Novartis)
Ethics approval obtained 2012,
studyВ commencingВ Feb 2013
• Clinical Lung Cancer Genome project
Principal investigator: Gavin Wright, Prue
Russell, Matthew Conron, Zoe Wainer, Dr Roman
Thomas
Study design: Exploratory epidemiological
geneticsВ study of FGFR1 mutation in non small
cellВ lung cancer
Primary Objective: To identify associations
between somatic FGFR1 genetic lesions (gene
amplifications / deletions / mutations and LOH)
andВ clinical outcomes in patients with squamous
cellВ carcinomaВ of the lung
• Lung Adenocarcinoma Grading Project
Principal investigators: Zoe Wainer,
MatthewВ Conron, Gavin Wright, Richard Williams,
Prue Russell
Study design: Prospective histopathological
analysis of lung adenocarcinoma
Primary Objective: To correlate the grading
ofВ lungВ adenocarcinoma with survival
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Respiratory Medicine
• Early Integration of Palliative Care in Oncology
(EIPCO) project.
Principal investigators: Jenny Philip, Katie Doan,
Matthew Conron, Shirley Carvosso, Di Saward,
Odette Spruyt, Dishan Gunawardana, Brian Le
andВ Linda Mileshkin
Study design: Exploratory qualitive study
Primary Objective: The aim of the sub-study was
to explore health care professionals’ perceptions
ofВ EIPCO for patients with incurable lung cancer.
• Does EGFR gene copy number alterations predict
EGFR mutation status?
Principal investigators: Prue Russell, YongВ Yu,
Hongdo Do, Timothy Clay, GavinВ Wright,
MatthewВ Conron, Zoe Wainer, Melissa Moore,
Richard Williams, Alexander Dobrovic,
SueВ AnneВ McLachlan
Study design: Pilot study
Primary Objective: The aim of the project
isВ toВ evaluate the utility of EGFR gene copy
numberВ alterations using CISH as a screening
toolВ for EGFRВ mutations
• Sleep/wake patterns and neurocognitive function
in doctors and medical students of an Australian
tertiary hospital
Principal investigators: Andrew Kyoong,
NaghmehВ Radhakrishna, Stephen Bowden,
KateВ Galloway, Cameron Stewart
Study design: Observational study
Primary objective: To evaluate sleep habits
ofВ doctors and medical students and its effects
onВ several domains of neurocognitive function
• A Phase III Multi-centre, randomised, Parallel
Group, Controlled, Double Blind Study to
Investigate theВ Safety and Efficacy of Inhaled
Mannitol over 12В Months in the Treatment of
Bronchiectasis.
Investigators: Dr David Hart, Dr Andrew
Kyoong, Dr Matthew Conron, Mrs Sue Brenton,
MsВ TamaraВ Matthews and Mr Cameron Stewart
• A Phase III, Randomised, Double-blind, PlaceboControlled Study Evaluating the Efficacy, Safety,
and Tolerability of Two Fixed Dose Combinations
ofВ Aclidinium Bromide/Formoterol Fumarate
Compared With Aclidinium Bromide, Formoterol
Fumarate and Placebo for 24 Weeks Treatment
inВ Patients With Moderate to Severe, Stable
ChronicВ Obstructive Pulmonary Disease (COPD)
(Sponsor: Forest)
Study completed in December 2012
Quality
Adenocarcinoma mutation analysis project
Staff
Dr David Hart, Director of Respiratory Medicine
Respiratory Consultants: Dr Matthew Conron,
DrВ Andrew Kyoong, Dr Piers Canty
Sue Brenton, Senior Respiratory Scientist;
Respiratory Scientists: Justin Pilmore,
CameronВ Stewart, Monica Lammers,
Respiratory Nurse Consultant: Maria Loder
Study nurses: Tamara Matthews (0.4EFT),
AliciaВ Redderhof (0.1EFT), Maria Garita (0.1 EFT)
Service to the wider community
Dr Matthew Conron
• Scientific Advisory Committee BioGRID
• Victorian Lung Cancer Registry
SteeringВ Committee
• Committee Victorian Branch Thoracic
SocietyВ ofВ Australia and New Zealand
Grants
Kyoong A
Sleep/ wake patterns and neurocognitive function
in doctors and medical students of an Australian
tertiary hospital, STV Research Endowment Fund
$7,116 for 2012
Sponsor: Pharmaxis Pty Ltd
Study completed October 2012
st vincent’s research report 2012
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Respiratory Medicine
Collaborations in research
Publications
• TOWER EFC10531
A Multi-Centre Double-Blind Parallel-Group
Placebo-Controlled Study Of The Efficacy
AndВ Safety Of Teriflunomide In Patients
WithВ Relapsing Multiple Sclerosis
The Department performed respiratory
functionВ testing for this study
Journal articles
• Early Integration of Palliative Care in Oncology
(EIPCO) project.
Principal investigators: Jenny Philip, Katie Doan,
Matthew Conron, Shirley Carvosso, Di Saward,
Odette Spruyt, Dishan Gunawardana, Brian Le
and Linda Mileshkin
• Victorian Cancer Agency –
LungВ CancerВ ResearchВ Collaboration
Principal investigator: Prof Neil Watkins,
MonashВ University, Melbourne
Primary Objective: To create a multi-centre
annotated resource of blood and tissue from
patients with resected early stage non-small
cell lung cancer that will facilitate clinical
andВ translational lung cancer research.
Wainer Z, Daniels MG, Callahan J, Binns D,
HicksВ RJ, Antippa P, Russell PA, Alam NZ,
ConronВ M, Solomon B, Wright GM. Sex and
SUVmax: Sex dependent prognostication in
earlyВ Non Small Cell Lung Cancer. J Nucl Med.
2012В Sep 14.
Conference publications
Is early integration of palliative care for patients
with incurable lung cancer acceptable to Australian
healthcare professionals? Doan K; Le B; Philip J;
Gunawardana D, Conron M, Spruyt O Saward D,
Carvosso S, Mileshkin L
Perceptions and attitudes to early integration of
palliative care for patients with incurable lung cancer:
results of a survey. Philip J; Doan K; Mileshkin L;
Spruyt O,Conron M, Gunawardana D, Carvosso S,
Saward D, Le B • Victorian Lung Cancer Registry
Primary Objective: To create the state based
registry of patients diagnosed with lung cancer
toВ allow reporting of outcomes and delivery
ofВ careВ to this patient population
• University of Melbourne, Parkville, Victoria
Melbourne School of Psychological Sciences
Sleep/wake patterns and neurocognitive function
in doctors and medical students of an Australian
tertiary hospital
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Rheumatology
St Vincent’s Department of Rheumatology
maintains a basic and clinical research program
that focuses on translating new knowledge
about rheumatology into effective treatment
forВ patients with rheumatic diseases.
About us
Our research topics are rheumatoid arthritis (RA),
osteoarthritis and systemic sclerosis. Research
into osteoarthritis is a top priority which we pursue
on both basic and clinical fronts. We specialise in
animal models which allow us to identify new drug
targets. A focus of this work is to understand how
the Wnt pathway controls the responses of bone in
this disease. The Unit participates in international
phase-3 trials of anti-TNF therapy in early RA, head
to head comparisons of biologic therapy and new
JAK kinase inhibitors in RA.
The focus of our work in systemic sclerosis is to
establish a large cohort study of scleroderma from
centres in Australia. We are investigating the risk
factors for developing heart and lung complications
in this serious disease.
Our recent projects looked at X-ray predictors
in Lung disease and new ways to screen for
Pulmonary Hypertension using biomarkers. The best
care depends at least as much upon excellent daily
care given in specialized clinics or centres aimed at
controlling all aspects of this complex disease as
upon the choice of one drug over another.
The National Scleroderma Registry and the
Australian Scleroderma Cohort Study (ASCS)
have enrolled over 1300 patients, with 25% being
recruited from St Vincent’s. The study is hosted by
St Vincent’s which hosts the database manager. The
unit is also participating in two Phase III clinical trials
and an international investigator-led observational
study of early diffuse scleroderma.
Major projects
1. Our study of a mouse knee osteoarthritis model
has shown that subchondral bone remodelling and
osteonecrosis of the bone are early and perhaps
defining features of the disease. Osteocytes
which regulate osteoblast function and express
the Wnt regulatory molecules sclerostin, DKK-1
and SFRP-1, are deficient in this disease.
2. Our study of a mouse model of rheumatoid
arthritis shows that the cytokine oncostatin
M, acting in concert with IL-1, regulates IL-6
expression. IL-6 antagonists and inhibitors of
JAK/STAT signalling such as tocilizumab will be
promising new therapies for rheumatoid arthritis.
3. Our study of 117 patients with connective tissue
disease associated pulmonary hypertension
showed that anticoagulation and combination
therapy with PAH specific vasodilators were
independent predictors of survival. Our findings
suggest that anticoagulation and combination
PAHВ therapy may improve survival in CTD-PAH.
Quality
1. By evaluating the predictive ability of the serum
biomarker N-Terminal pro-Brain Natriuretic
Peptide for detection of incident pulmonary
arterial hypertension in systemic sclerosis (SScPAH), we derived a novel screening algorithm
for SSc-PAH that incorporates NT-proBNP
measurement and pulmonary function tests
to replace echocardiography as the �first tier’
ofВ screening.
2. In a study of Lung disease in scleroderma we
confirmed that extent of disease on CT scans
isВ predictive of outcome in SSc-ILD. However,
inВ follow-up of patients, pulmonary function
tests are as reliable and less costly, without
theВ associated radiation exposure.
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Rheumatology
Staff
A/Prof Evange Romas, Head of Department
ofВ Rheumatology [No research EFT]
Clinical A/Prof Laurie Clemens, Head of Clinical
TrialsВ Group [No research EFT]
Dr Wendy Stevens, Head of Scleroderma Clinic
[0.1В EFT]
Dr Keith Lim, Head of Osteoarthritis (OWL)
ClinicВ [NoВ research EFT]
Dr Nicole Walsh, Basic Rheumatology
ResearchВ Unit, 1.0 EFT
Dr Vivek Thakkar, PhD student, 1.0 EFT
Dr Owen Moore, Research fellow, 1.0 EFT
Dr Mandana Nikpour, Senior Lecturer, 0.8 EFT
Ms Candice rabusa, Project Officer for ASIG,
1.0В EFT
Ms Barbara Gemell, Research Nurse, 1.0 EFT
Mary Sullivan, Research Nurse, 0.5 EFT
Students
Dr Vivek Thakkar, Doctor of Medical Science
Service to the wider community
A/Prof Evange Romas:
• Chair, Australian Rheumatology Association
Therapeutics Committee
• Member, Australian Rheumatology Association
Research Trust
• Member, International Treat-to-Target Steering
Committee
• Reviewer for journals Arthritis & Rheumatism,
Rheumatology, Journal of Immunology and Bone
• NHMRC Grant reviewer
Grants
Nicole Walsh, Natalie Sims, Evange Romas
Wnt Signalling in Experimental Osteoarthritis,
NHMRC
$540,000 for 2010–2012 ($175,000 in 2012)
Mandana Nikpour
Barbara Cameron Fellowship, The Royal
Australasian College of Physicians and
AustralianВ Rheumatology Association
$95,000 for 2011–2012 ($45,000 in 2012)
Wendy Stevens, Susanna Proudman,
PeterВ Youssef, Mandana Nikpour on behalf
ofВ theВ Australian Scleroderma Interest Group
Australian Scleroderma Screening Program
for Pulmonary Arterial Hypertension, Actelion
Pharmaceuticals
$300,000 for 2010–2012 ($100,000 in 2012)
Clemens L, Romas E
Apremilast in psoriatric arthritis, Sanofi Aventis
$25,000 for 2011–2012 ($12,000 in 2012)
Romas E, Clemens L
Study to Evaluate MTX + Certolizumab versus
MTXВ + placebo in early RA, UCB
$50,000 for 2012–2014 ($10,000 in 2012)
Stevens W
Novel biomarkers in the assessment of risk for the
development of pulmonary arterial hypertension in
systemic sclerosis., St Vincents Hospital Research
Endowment Fund
$20,000 for 2012
Thakkar, V
Risk factors for Pulmonary Hypertension
inВ scleroderma, NHMRC
$82,144 for 2012–2013 ($41,072 in 2012)
Stevens W, Nikpour M, Thakkar V
DUAL study: Prospective, Randomized, Placebocontrolled, Double-blind, Multicenter, Parallel Group
Study to Assess the Efficacy, Safety and Tolerability
of macitentan in Patients With Ischemic Digital
Ulcers Associated With Systemic Sclerosis, Actelion
$10,000 in 2012
Stevens W, Prior D, Conron M, Thakkar V
Griphon; A Multicenter, Double-blind, Placebocontrolled Phase 3 Study to Demonstrate the
Efficacy and Safety of ACT-293987 in Patients
WithВ Pulmonary Arterial Hypertension, Actelion
$35,000 in 2012
Collaborations in research
International
• University of Massachusetts, Worcester, USA
• University of Nantes, Nantes, France
• Oxford University, United Kingdom
• University of Toronto, Toronto, Canada
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Rheumatology
National
• Murdoch Institute, Melbourne
• Prince Henry’s Institute, Melbourne
• Royal Perth Hospital, Perth, WA
• Royal Adelaide Hospital, Adelaide, South Australia
• Monash Medical Centre, Clayton Vic
• Royal Prince Alfred, Sydney, NSW
• Royal North Shore Hospital, Sydney NSW
• Menzies Institute Hobart, Tasmania
• St George Hospital Sydney NSW
• Queen Elizabeth Adelaide, South Australia
• John Hunter Newcastle, NSW
• Canberra Hospital ACT
• Sunshine Coast Rheumatology, Queensland
Publications
Journal articles
McKelvie PA, Oon S, Romas E, Nandurkar H,
Tam CS. Systemic anaplastic large cell lymphoma
associated with hyper-eosinophilia, granulomatous
myositis and vasculitis. Leuk Lymphoma. 2012;
53(11):2279-82.
Sims NA, Walsh NC. Intercellular cross-talk
amongВ bone cells: new factors and pathways.
Curr Osteoporos Reports. 2012;10(2):109–17.
Thakkar V, Stevens W, Prior D, Moore O, et
al. N-terminal pro-brain natriuretic peptide in a
novel screening algorithm for pulmonary arterial
hypertension in systemic sclerosis: a case-control
study. Arthritis Research & Therapy 2012; 14:R143.
Moore O, Goh N, Corte T, Rouse H, Hennessy O,
Byron J, Vivek Thakkar V, Sahhar J, Gabbay E,
Roddy J, Youssef P, Nash P, Zochling J, ProudmanS,
Stevens W, Nikpour M. Extent of Disease on HighResolution CT Lung is a Predictor of Decline and
Mortality in Systemic Sclerosis-Related Interstitial
Lung Disease. Rheumatology (Oxford) 2013;52
(1):155–60.
Ngian GW, Sahhar J, Proudman SM, Stevens W,
et al. Prevalence of coronary heart disease and
cardiovascular risk factors in a national crosssectional cohort study of systemic sclerosis.
Ann Rheum Dis 2012 Dec ;71(12):1980–3.
Thakkar V, Moore O, Stevens W, Nikpour M.
Managing Scleroderma: challenges in primary
care. Medicine Today 2012; 13(6): 35–42.
Treatment of systemic sclerosis complications: what
to use when first-line treatment fails- a consensus
of systemic sclerosis experts. Walker KM, Pope J;
participating members of the Scleroderma Clinical
Trials Consortium (SCTC); Canadian Scleroderma
Research Group (CSRG). Semin Arthritis Rheum.
2012 Aug;42(1):42–55.
Tang C, Godfrey T, Stawell R, Nikpour
M.Hydroxychloroquine in lupus: emerging
evidence supporting multiple beneficial effects.
Intern Med J. 2012 Jul 25. doi: 10.1111/j.1445–
5994.2012.02886.x. [Epub ahead of print]
Conference publications
Vivek Thakkar, Karen Patterson,
WendyВ Stevens, Jillian Byron, Owen Moore,
Janet Roddy, JaneВ Zochling, Joanne Sahhar,
PeterВ Nash, KathleenВ Tymms, Peter Youssef,
SusannaВ Proudman, Mandana Nikpour and
Pravin Hissaria. Novel Biomarkers of Dysregulated
Angiogenesis Are Not Specific to Pulmonary
Arterial Hypertension in Systemic Sclerosis.
Poster presentation 2nd Systemic Sclerosis
WorldВ Congress, Madrid, Spain, February 2012.
Internal Medicine Journal 2012; 42(suppl. 1):21.
Vivek Thakkar, Karen Patterson, WendyВ Stevens,
Jillian Byron, Owen Moore, Janet Roddy,
JaneВ Zochling, Joanne Sahhar, PeterВ Nash,
KathleenВ Tymms, Peter Youssef, SusannaВ Proudman,
Pravin Hissaria and Mandana Nikpour. Serum
ICAM-1 Levels are Related to the Presence of
Interstitial Lung Disease in Systemic Sclerosis.
Poster presentation 2nd Systemic Sclerosis
WorldВ Congress, Madrid, Spain, February 2012.
Internal Medicine Journal 2012; 42(suppl. 1):22.
Ngian G, Stevens W, Prior D, Roddy J, et al.
Predictors of Mortality in Connective Tissue DiseaseAssociated Pulmonary Arterial Hypertension: a
cohort study. Arthritis Research & Therapy 2012
14:R213.
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Rheumatology
Wendy Stevens, Vivek Thakkar, Owen Moore,
Jillian Byron, Susanna Proudman, Jane Zochling,
Janet Roddy Joanne Sahhar, Peter Nash, Peter
Youssef, Gabor Major, Kathleen Tymms, Catherine
Hill, Alan Sturgess, Leslie Schrieber and Mandana
Nikpour. Lung disease is the major cause of death
in the Australian Systemic Sclerosis Cohort study.
Poster presentation 2nd Systemic Sclerosis World
Congress, Madrid, Spain, February 2012.
Speaking engagements
Vivek Thakkar, Wendy Stevens, David Prior,
JillianВ Byron, Karen Patterson, Pravin Hissaria,
OwenВ Moore, Janet Roddy, Jane Zochling,
JoanneВ Sahhar, Peter Nash, Kathleen Tymms,
PeterВ Youssef, Susanna Proudman and
MandanaВ Nikpour. N-Terminal pro-Brain
NatriureticВ Peptide (NT-proBNP) Levels Predict
Incident Pulmonary Arterial Hypertension in
SystemicВ Sclerosis (SSc). Poster presentation
2ndВ Systemic Sclerosis World Congress, Madrid,
Spain, February 2012.
Jac Charlesworth, Jim Stankovich, Patricia Lewis,
Jillian Byron, Wendy Stevens, Joanne Sahhar,
Susanna Proudman, Janet Roddy, Peter Nash,
Kathleen Tymms, Matthew Brown, Jane Zochling.
An immunochip based interrogation of scleroderma
susceptibility variants. Oral presentation 2nd
Systemic Sclerosis World Congress, Madrid,
Spain,В February 2012.
Owen Moore, Nicole Goh, Tamera Corte,
HannahВ Rouse, Oliver Hennessy, Jillian Byron,
Vivek Thakkar, Joanne Sahhar, Janet Roddy,
PeterВ Youssef, Peter Nash, Jane Zochling,
SusannaВ Proudman, Wendy Stevens and
MandanaВ Nikpour. Extent of Lung Disease
onВ High-Resolution CT Lung is a Predictor
ofВ Mortality inВ Systemic Sclerosis-Related
InterstitialВ Lung Disease. Oral presentation
2ndВ Systemic Sclerosis World Congress,
Madrid,В Spain, February 2012.
Owen Moore, Nicole Goh, Tamera Corte,
HannahВ Rouse, Oliver Hennessy, Jillian Byron,
Vivek Thakkar, Joanne Sahhar, Janet Roddy,
PeterВ Youssef, Peter Nash, Jane Zochling,
SusannaВ Proudman, Wendy Stevens and
MandanaВ Nikpour. Identifying and Quantifying
Prognostic Factors in Systemic Sclerosis-Related
Interstitial Lung Disease Using a Time-Varying
Covariate Survival Model. Oral presentation
2ndВ Systemic Sclerosis World Congress, Madrid,
Spain, February 2012.
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University of Melbourne
Department of Medicine
The University of Melbourne Department of
Medicine, St Vincent’s is a research-intensive
department of the Melbourne Medical School.
The Department has broad research interests
which aim to develop solutions with direct
clinical application. Through a strong research
training program, the department trains the next
generation of basic and clinical researchers.
About us
The Department has a wide breadth of research
interests that span basic wet-lab science, health
economics and clinical epidemiology, clinical
trials that test efficacy of new drugs and life
style modifications and extend into the area
ofВ translational research. The latter has special
emphasis given the location of the Department
within a tertiary hospital that hosts several iconic
clinical services.
The core research foci have been on diabetes
and its complications, kidney disorders, vascular
disease, nutritional intervention, inflammation and
thrombosis. In particular, the Department’s research
activities within the Cardiovascular and Diabetes,
Obesity andВ Endocrinology Research Domains
haveВ achieved international recognition.
New areas of activity include genetics ofВ leukaemia,
inflammatory bowel disease and otherВ gastrointestinal
disorders, clinical neurosciences, innate immunity and
infectious diseases, as well asВ health services research.
The Department of Medicine supports the hospital
through teaching, clinical leadership and health
policy development.
Major projects
Prof Darren Kelly and his research group have
beenВ involved in several major research projects
involving investigations into anti-fibrotic therapies
forВ the treatment of heart and kidney failure,
diabetes, hypertension and drug discovery.
DiabetesВ is associated with increased risk of
cardiovascular disease which can ultimately lead
to premature death. The metabolic disturbances
seen in diabetes can induce a state of inflammation
and initiate scar tissue formation (fibrosis) in various
organs of the body contributing to the decline in
organ function, particularly in the heart and kidney.
At present there is no effective treatment for the
prevention of organ fibrosis seen in diabetic heart
and kidney disease. Professor Kelly’s research
teamВ is investigating the effect of novel antifibrogenic therapies in animal models of diabetes
withВ heart and kidney disease similar to what
isВ seenВ in human patients with diabetes.
An exciting development from this research
hasВ been the collaboration between Prof Kelly
andВ his team and the Bio21 Institute, which
hasВ ledВ to several patents being filed and licensed
into a start up biotechnology company, Fibrotech
Therapeutics. Prof Kelly and Fibrotech Therapeutics
have developed a new drug to treat fibrosis in
diabetic kidney disease (FT-11), and Phase 1 clinical
trials inВ humans are expected to commence in 2013.
The information gained from these studies will allow
rapid translation of pre-clinical proof of concept data
into clinical development for a new therapy for both
diabetic kidney and heart disease.
As part of a collaborative effort with the Austin
andВ Royal Melbourne Hospitals, Prof Mark Cook
led a team of researchers in successfully developing
and testing a device implanted in the brain that
may be able predict epileptic seizures in humans
byВ picking up early warning signs. Results of the
test, conducted in 15 people, were published in
Lancet Neurology and funded by Neurovista. Such
a device has significant implications not only in the
day-to-day management of patients with epilepsy
but potentially be a life-changer for those currently
living with epilepsy.
This groundbreaking study has garneredВ international
media attention, with news outlets such as the BBC
picking up the story.
Prof Harshal Nandurkar and his research team
wereВ involved in the following projects:
• Eight different clinical trials investigating new
andВ established drugs in different haematological
malignancies.
• Identification of a novel regulator of haemostasis,
GRP78, which has strong anti-clotting activity in
mouse models and can be expanded to human use.
• Investigation of the basis of miscarriages in
women with the autoimmune disorder lupus,
with the hypothesis being the inactivation of
anВ important protein in blood vessels that helps
toВ control clotting and inflammation.
st vincent’s research report 2012
167
University of Melbourne Department of Medicine
• Identification of new genes associated with
acute myeloid leukaemia through highly refined
molecular biology techniques.
Dr Christopher Plummer, Clinical Research Fellow
Prof Michael Kamm and his research team
haveВ been involved in the following projects:
Dr Laima Brazionis, Teamsnet Program Director
• Post Operative Crohn’s Endoscopic Recurrence
(POCER) Study (ongoing)
• Cancer Surveillance in Inflammatory
BowelВ Disease (IBD)
• Management of Fistulising Crohn’s
DiseaseВ (ongoing)
A/Prof Leslie Norman Jones, Principal
ResearchВ Fellow
Ms Robyn Suzanne Kelly, Research Assistant/
Histology Technologist
Dr Amanda Jane Edgley, NHMRC
ResearchВ Academic
Dr Andre La Gerche, Overseas Clinical
TrainingВ Fellow
Ms Jodie Clair Horsburgh, Clinical Trials Co-ordinator
• International Multicentre Trial in Recurrent
AcuteВ Diverticulitis (ongoing)
Prof Michael Kamm, Professorial Fellow
• IPNIC Study, aimed at developing a tissue damage
score for patients with Crohn’s disease
Dr Christina Yan Ru Tan, Research Fellow
• Ongoing work focussing on research into
epidemiology, genetics, clinical aspects,
andВ clinical trials in IBD in Asia.
Ms Amy Louise Hamilton, Clinical Trials Coordinator
Staff
Dr Sven-Erik Bursell, Senior Research Fellow
Dr Nicholas Rufaut, Senior Research Fellow
Mr Simon Vogrin, Neuroimaging Data Analyst
Dr Jake Sui, Research Fellow
A/Prof David Norman O’Neal
Dr Jacqueline Mary Walters-Bressan,
ResearchВ Fellow
Prof Mark James Cook, Chair Of Medicine
A/Prof Alicia Jenkins
A/Prof Andrew Michael Wilson, Principal Research
Fellow, and Research Assistant NHMRC
Miss Efrosinia Soula Krejany, Clinical Scientist
Mrs Fatima Mary Sullivan, Research Nurse
A/Prof Peter Anthony Foley
Mr Peter Charles Tonoli, Information
TechnologyВ Manager
Ms Sylvia Glowacka, Laboratory Technician
Dr Mandana Nikpour, Senior Research Fellow
A/Prof David Lloyd Prior
Miss Mariana Ines Pacheco, Animal Facility Manager
Dr Yuan Zhang, Research Fellow
Prof Harshal Hanumant Nandurkar
Dr Marno Celeste Ryan, Research Fellow
Prof Darren James Kelly
Ms Alison Joy Cox, Research Assistant
A/Prof Paul Vincent Desmond
Students
Benjamin Condon, Honours Student
Karolina Novak, Honours Student
Maria Soetjipto, Honours Student
George Yang, Honours Student
Georgina Cameron, Doctor of Medical
ScienceВ Student
Miss Jemma Clare Court, Animal House Technician
Carmela Carputo, Doctor of Medical
ScienceВ Student
A/Prof Wendy Jude D’souza
Timothy Clay, Doctor of Medical Science Student
Dr Alvin Chong, Senior Lecturer
Bianca DeVitt, Doctor of Medical Science Student
Ms Amy Louise Wilson-O’Brien, Research Fellow
Michael Dickinson, Doctor of Medical
ScienceВ Student
Dr Alexander James Thompson, Neil Hamilton
Fairley Research Fellow
Thai Hong, Doctor of Medical Science Student
st vincent’s research report 2012
168
University of Melbourne Department of Medicine
Sybil McAuley, Doctor of Medical Science Student
Siew-Min Gan, PhD Student
Stuart Murch, Doctor of Medical Science Student
Chen Gao, PhD Student
Olga Niewiadomski, Doctor of Medical
ScienceВ Student
Nicolas Hoch, PhD Student
Sonny Palmer, Doctor of Medical Science Student
Allison Irvin, PhD Student
Corrie Studd, Doctor of Medical Science Student
Gaurang Jhala, PhD Student
Helen Sweeting, Doctor of Medical Science Student
Matthew Jenkins, PhD Student
Vivek Thakkar, Doctor of Medical science Student
Chacko Joseph, PhD Student
Niranjan Arachchi, MD Student
Sarah Kamel, PhD Student
Catherine Croagh, MD Student
Fay Khong, PhD Student
Hope Dinh, MD Student
Hansoo Kim, PhD Student
Thuy Dinh, MD Student
Suang Suang Koid, PhD Student
Despina Handolias, MD Student
Matthew Ku, PhD Student
Kenneth Khamly, MD Student
Jamie Layland, PhD Student
Tin Nguyen, MD Student
Heather Lane, PhD Student
Valerie Tay, MD Student
Xianning Lai, PhD Student
Shireene Vethakkan, MD Student
Xianzhong Lau, PhD Student
Lorraine Godfrey, Master of Science
(Research)В Student
Brian Liddicoat, PhD Student
Mansi Patel, Master of Medicine Student
Stephanie Tan, Master of Medicine Student
John Garlick, MPhil (Medicine) Student
Hector Damian Hernandez De Santiago,
MPhilВ (Medicine) Student
Jacinta Holmes, PhD Student
Jasmine Lyons, PhD Student
Ben Ma, PhD Student
Kevin Mittelstaedt, PhD Student
David Moses, PhD Student
Alvin Jin Ming Ng, PhD Student
Niyati Sharma, MPhil (Medicine) Student
Hayley O’Neill, PhD Student
Azar Asgari, PhD Student
Vimukthi Pathiraja, PhD Student
Michelle Ashton, PhD Student
Illana Prideaux, PhD Student
Rachel Blake, PhD Student
Hong Sheng Quah, PhD Student
Shreya Bhattacharya, PhD Student
Siddarth Rajakumar, PhD Student
Maria Brosnan, PhD Student
Mahsa Rashidi, PhD Student
Dennis Carney, PhD Student
Veena Roberts, PhD Student
Jonathan Chee, PhD Student
Siti Nur Ain Roesley, PhD Student
SweeLin Chen, PhD Student
Anushka Samudra, PhD Student
Joanne Chia, PhD Student
Anup Sharma, PhD Student
Ling Yeong Chia, PhD Student
Udaya Seneviratne, PhD Student
Edward Po-Fan Chu, PhD Student
Timothy Smith, PhD Student
Jennifer Coller, PhD Student
Farzin Takyar, PhD Student
Peter de Cruz, PhD Student
Michael Tan, PhD Student
Sherine M Fernando, PhD Student
Julian Wai-Kit Tang, PhD Student
st vincent’s research report 2012
169
University of Melbourne Department of Medicine
Prerak Trivedi, PhD Student
Jane Varney, PhD Student
Mark Waddingham, PhD Student
Jibran Wali, PhD Student
• Member, ASN/ FDA Kidney Health
InitiativeВ Advisory Group
• Member, RMIT Pharmaceutical Sciences
ProgramВ Advisory Committee
Anosha Yazdabadi, PhD Student
• Member, Faculty of the Australasian
ReninВ Academy
Theses passed in 2012
Dr Amanda Edgley
Kathryn Cimdins, PhD, University of Melbourne
• Member, Animal Ethics Committee,
St Vincent’s Hospital
Vanessa Cheung, PhD, University of Melbourne
Hayden Eastwood, PhD, University of Melbourne
Professor Harshal Nandurkar
Chatura Jayasekara, Doctor of Medical Science,
University of Melbourne
• Chair, St Vincent’s Alumni Committee
Saar Gill, PhD, University of Melbourne
Sabine Jurado, PhD, University of Melbourne
Eddy Kwong-Fei Lee, PhD, University of Melbourne
Alice Schofield, PhD, University of Melbourne
• Member, Board of the St. Vincent’s Foundation
• Member, Senior Medical Staff Executive Council,
St Vincent’s Hospital
• Chair, Quality Improvement Presentations,
St Vincent’s Hospital
Shanna Tam, PhD, University of Melbourne
• Member, Research Training Committee,
EasternВ Hill Academic Centre,
UniversityofВ Melbourne
Service to the wider community
• Member, University of Melbourne St Vincent’s
Academic Centre Executive Committee
Prof Mark Cook
• Member, Cancer Executive Council
• Associate Editor, Epilepsia
• Member, Pathology Executive Council
• Chairman, Animal Ethics Committee,
St Vincent’s Hospital
• Chair, VTE Committee
Christina Yan-Ru Tan, PhD, University of Melbourne
• Member, Board of the St Vincent’s Foundation
• Member, Board of the O’Brien Institute
• President, Epilepsy Foundation of Victoria
Prof Darren Kelly
• Director and CEO of Fibrotech Theraputics
• Director, Research Training Committee, Eastern Hill
Academic Centre, UniversityВ ofВ Melbourne
• Member, Faculty of Medicine Post Graduate
Committee, University of Melbourne
• Secretary, Australian Society of Haemostasis
andВ Thrombosis
Professor Michael Kamm
• Chair, Working group on cancer surveillance
inВ Inflammatory Bowel Disease, Australian Cancer
Network and NHMRC
Associate Professor Andrew Wilson
• Convenor, Bio 21 Victorian Clinical
ResearchВ Network Forum
• Member, Program Committee, CRX 2010
• Member, Faculty of Medicine Commercialisation
Committee, University of Melbourne
• Chair, Expert Advisory Group
onВ Accreditation,В RACP
• Subject Editor, Board of Nephrology
• Chair, Accreditation Subcommittee, RACP
• Member, Scientific Programming
andВ EducationВ Committee, ANZSN
• Member, Adult Medicine Division
EducationВ Committee, RACP
st vincent’s research report 2012
170
University of Melbourne Department of Medicine
Associate Professor Alicia Jenkins
• Speaker to community audiences regarding
TypeВ 1 diabetes
• Board Member of Insulin For Life that provides
diabetes supplies to over 30 developing
countriesВ Australian Diabetes Society
CouncillorВ and Treasurer
• Member of Committees for Diabetes
EmergencyВ Response
• Type 1 diabetes clinical communication
andВ technology use
• Member of Expert Advisory Panel
forВ NHMRCВ Type 1 diabetes guidelines
• Member of the Victorian insulin pump
advisoryВ group
• Member of several community based
Type1В diabetes groups such as HypoActive
• Member of group to develop Lipid Guidelines
inВ Diabetes
Dr David O’Neal
• Member of group to develop Lipid Guidelines
inВ Diabetes
• Member of the Victorian insulin pump advisory
GRANTS and/or RESEARCH INCOME
Best JD
Ccre In Clinical Science In Diabetes – 454461
– Best 2007, NHMRC
$1,844,600 for 2007–2012
D’apice AJF
Which Transgenic Pig Will Be Used For Islet
Transplantation In Humans? NHMRC
$3,026,134 for 2007–2013
Cowan PJ
Preclinical Studies In Xenotransplanation, NHMRC
$1,204,895 for 2009–2012
Thompson AJA
Genetic determinants of clinical outcome and
treatment response in chronic hepatitis C, NHMRC
$369,391 for 2009–2012
Kelly DJ
NHMRC Research Fellowship 2009 – Kelly, NHMRC
$572,467 for 2009–2013
Broadhead M
Pigment epithelium-derived factor (PEDF) - how can
this protein be used to treat bone cancer? NHMRC
$116,673 for 2009–2012
Kim H
Epidemiological and economic modelling
ofВ diabetesВ and its complications in the
contemporary Australian setting, NHMRC
$85,827 for 2009–2013
De Cruz P
Medical Postgraduate Scholarship: Post-Operative
Crohn’s Disease: Cause And Prevention, NHMRC
$116,693 for 2009–2012
Devitt B
An examination of the dynamics and
processesВ ofВ multidisciplinary cancer
meetings,В VicВ Cancer Agency
$58,064 for 2009–2013
D’souza WJ
Common Susceptibility Genes Underlying
TheВ Idiopathic Generalized Epilepsies (Ige)?
AВ Genome-Wide Scanning Approach, NHMRC
$208,861 for 2009–2013
Michael M
Novel methods to predict the pharmacology
andВ effect of anticancer drugs, NHMRC
$804,813 for 2010–2013
Kamm M
Practitioner Fellowship – Prof Michael Kamm,
NHMRC
$529,132 for 2010–2014
Prince HM
Identifying And Targeting Myeloma Stem Cells In
AВ Novel Mouse Model And In Humans, Aust Rotary
Health Research Fund
$180,000 for 2009–2012
Kemp BE
Systems Therapeutics for Metabolism: AMPK
Isoform Specific Drugs, Aust Research Council
$368,242 for 2010–2012
Fernando M
Invasive growth of basal cell skin cancer: insights
from a molecular comparison with hair growth,
NHMRC
$107,750 for 2010–2013
st vincent’s research report 2012
171
University of Melbourne Department of Medicine
Cook MJ
Advanced Polymer Systems For The Delivery
OfВ Anti-Epileptic Drugs To The Cns, NHMRC
$376,008 for 2010–2013
Mcarthur G
Understanding Inhibition of BRAF in Melanoma,
NHMRC
$484,746 for 2011–2013
Kelly DJ
Preclinical development of a novel compound
toВ treat diabetic heart disease, NHMRC
$488,392 for 2011–2013
Murch S
Novel biomarkers of cardiovascular risk: focus
onВ nitric oxide biology and plaque assessment,
Pfizer Aust Pty Ltd
$50,000 for 2010–2012
Cook MJ
Pinpointing the cause of epilepsy in the brain,
NHMRC
$528,652 for 2012–2014
Badawy RABR
Cortical Excitability And Epilepsy, NHMRC
$359,905 for 2012–2017
Nikpour M
Prevalence, correlates and variability over time of
cardiovascular risk factors in rheumatoid arthritis,
Royal Aust College Of Physicians
$50,000 for 2010–2012
Nikpour M
Risk factors for the development of pulmonary
arterial hypertension in systemic sclerosis: a
prospective cohort study, Pfizer Aust Pty Ltd
$45,000 for 2012–2014
Layland J
Physiology Of Acute Coronary Syndromes:
FocusВ On Microvascular Dysfunction, NHMRC
$93,765 for 2011–2013
Thompson AJA
Immunology of IL28B variation in patients with
chronic hepatitis C, University Of Melbourne
$40,000 for 2012–2012
Chew G
Cellular, Molecular And Genetic Aspects
OfВ HighВ Mammographic Density, NHMRC
$115,122 for 2011–2014
Ryan MC
Ryan – Career Interruption Fellowship 2012,
University Of Melbourne
$65,000 for 2012–2012
Brosnan M
The Effect Of Exercise Training On Cardiac Structure,
Function And The Electrocardiogram In Indigenous
And Non-Indigenous Elite Australian Athletes,
NHMRC
$124,668 for 2011–2014
Mcauley S
Insulin Pump Therapy In Type 1 Diabetes: Vascular
Health And Basal Insulin Kinetics, Royal Aust College
Of Physicians
$50,000 for 2012–2013
Roberts V
Targeted delivery of CD39 Protects Against Ischemia
Reperfusion Injury, Royal Aust College Of Physicians
$30,000 for 2011–2012
Nandurkar HHt
Study of new mechanisms that control
bloodВ clotting, National Heart Foundation
$129,000 for 2011–2013
Bursell SE
Telehealth Facilitation Of Diabetes And
Cardiovascular Care In Australia, NHMRC
$1,234,959 for 2011–2014
Cook MJ
Pinpointing the cause of epilepsy in the brain,
NHMRC
$113,698 for 2012–2014
Kamel S
Characterisation of GRP78 as a Novel Regulator
of Haemostasis and Thrombosis, Royal College
OfВ Pathologists Of Australasia
$50,000 for 2011–2013
Holmes J
Studies of the immunological determinants
ofВ theВ relationship between IL28B genotypic
variants,В Gastroenterological Society Of Australia
$112,587 for 2012–2015
st vincent’s research report 2012
172
University of Melbourne Department of Medicine
Conaglen P
Investigation Of Insulin Resistance
InВ HeartВ SurgeryВ Patients, NHMRC
$73,072 for 2012–2014
Chen SL
HOST IL28B Genotype & Patterns Of Interferon
Stimulated Gene Expression In Patients With
Chronic Hepatitis C, Gastroenterological Society
OfВ Australia
$112,587 for 2012–2015
Collaborations in research
International
• University of Eastern Finland, Savonlinna, Finland
• University of Aberdeen, Aberdeen, UK
• California Polytechnic State University,
CaliforniaВ USA
• Akershus University College, Oslo, Norway
• University of Oklahoma, Medical University
ofВ South Carolina
Ku M
Identification and analysis of novel oncogenic
mechanism in deletion 20q Acute Myeloid
Leukaemia, Haematology Society Of Australia
AndВ New Zealand
$50,000 for 2012–2013
• University of Missouri
Dwyer, K
Role Of Purines In Renal And Transplant Injury,
NHMRC
$215,003 for 2012–2014
• USA Shire – multicentre international
studyВ onВ diverticular disease
Wilson AM
The Role Of The DDAH/ADMA/NOS Pathway
InВ Insulin Resistance And Endothelial Biology,
National Heart Foundation
$102,010 for 2012–2014
Scott AT
Measuring, Assessing And Explaining
HospitalВ Performance, NHMRC
$229,000 for 2010–2014
Jenkins A
Digital Retinal Camera Purchase, Rebecca L Cooper
Medical Research Foundation Ltd
$20,000 for 2012–2012
Grossmann M
Testosterone For The Prevention Of Diabetes
Mellitus In High Risk Men: A Randomised Trial,
NHMRC
$391,742 for 2012–2016
Scott AT
Measuring, Assessing And Explaining
HospitalВ Performance, NHMRC
$79,000 for 2010–2014
• University of Oslo
• University of Hawaii
• St Mark’s Hospital, London, UK
• St Michael’s Hospital, Toronto, Canada
• Hong Kong – Professor Joseph Sung, President
of the Chinese University of Hong Kong and
Assistant Professor Siew Ng at the Prince
of Wales Hospital and Chinese University
ofВ HongВ Kong
• China – Professor Bing Xia at Zhongnan
HospitalВ in Wuhan
• China – Professor Qin Ouyang in Chengdu.
• China – Professor Liping Zhao
atJiaoВ TongUniversity in Shanghai
• Beth Israel Deaconess Medical Center,
Boston,В USA
• University of British Columbia, Vancouver, Canada
• MD Anderson Centre, University of Texas, USA
National
• University of Sydney
• University of Adelaide
• University of Western Australia
• University of Canberra
• Deakin University
• Monash University
• Baker IDI Heart and Diabetes Institute
atВ AliceВ Springs
• University of Western Australia, Perth, WA
• University of South Australia, Adelaide, SA
st vincent’s research report 2012
173
University of Melbourne Department of Medicine
• Menzies School of Health Research, Darwin, NT
• Baker IDI Heart and Diabetes Institute,
Prahran,В VIC
• Centre for Eye Research Australia, University
ofВ Melbourne, East Melbourne, VIC
• Centre for MEGA Epidemiology, University
ofВ Melbourne, VIC
• The Walter and Eliza Hall Institute, VIC
• St Vincent’s Institute of Medical Research, VIC
• Australian Centre for Blood Diseases,
AlfredВ Hospital, Monash University, VIC
• Department of Biochemistry and Molecular
Biology, Monash University, VIC
• Post Operative Crohn’s Endoscopic Recurrence
(POCER) study – 22 hospitals in Australia and
Christchurch Hospital, New Zealand
• CSIRO–Molecular Health technologies,
Parkville,В VIC
• Murdoch Children’s Research Institute
– Dr Carl Kirkwood
• Department of Nephrology, St Vincent’s Hospital
• Department of Immunology,
MonashВ University,В VIC
• Department of Physiology, Monash University, VIC
• Victorian Life Sciences Computing Initiative
(VLSCI), Melbourne
• Australian Synchrotron, VIC
Publications
Book chapters
Jackson GD, Badawy R & Gotman J. 2012.
Functional magnetic resonance imaging: focus
localization. In Stefan H & Theodore W (eds),
Handbook of Clinical Neurology. Netherlands:
Elsevier BV, pp. 369–385.
Journal articles referred
Ackerman I, Brooks PM, Degenhardt LJ, MarksВ R,
Room RG, Steer AC, Taylor HR, Weintraub RG,
Cowie BC & Lopez AD. 2012. Disability-adjusted
life years (DALYs) for 291 diseases and injuries
in 21 regions, 1990–2010: a systematic analysis
for theВ Global Burden of Disease Study 2010.
The Lancet. 380 (9859); 2197–2223.
Ackerman I, Brooks PM, Degenhardt LJ, MarksR,
Room RG, Steer AC, Taylor HR, Weintraub RG,
Cowie BC & Lopez AD. 2012. Years lived with
disability (YLDs) for 1160 sequelae of 289 diseases
and injuries 1990–2010: a systematic analysis
fortheВ Global Burden of Disease Study 2010.
ThexLancet. 380 (9859); 2163–2196.
Alavi, Grebely, Matthews, Petoumenos, Yeung,
DayВ C, Lloyd AR, Van Beek, Kaldor JM, Hellard,
Dore GJ, Haber PS & Desmond PV. 2012. Effect
ofВ pegylated interferon-alpha-2a treatment
onВ mentalВ health during recent hepatitis C virus
infection. Hepatology. 27 (5); 957–965.
Angstetra, Graham, Zhao, Irvin, Elkerbut,
Santamaria, Slattery, Kay TW & Thomas H.
2012. AnВ indirect role for NK cells in a CD4(+)
T-cell-dependent mouse model of type I diabetes.
Immunology and Cell Biology. 90 (2); 243–247.
Ansarullah, Bharucha B, Umarani M,
DwivediВ M, Laddha NC, Begum R, HardikarВ AA
&В Ramachandran AV. 2012. Oreocnide
integrifolia Flavonoids Augment Reprogramming
for Islet Neogenesis and Гў-Cell Regeneration
inВ Pancreatectomized BALB/c Mice. EvidencebasedВ Complementary and Alternative Medicine.
2012; 260467.
Ascher DB, Polekhina G & Parker MW. 2012.
Crystallization and preliminary X-ray diffraction
analysis of human endoplasmic reticulum
aminopeptidase 2. Acta Crystallographica
Section F – Structural Biology and Crystallization
Communications. 68 (4); 468–471.
Auger, Harper, Barry, Trempe & Daniel M. 2012. Life
expectancy gap between the Francophone majority
and Anglophone minority of a Canadian population.
European Journal of Epidemiology. 27 (7); 27–38.
Badawy RAB, Loetscher T, Macdonell RAL
&В Brodtmann A. 2012. Cortical excitability
andВ neurology: insights into the pathophysiology.
Functional Neurology. 27 (3); 131–145.
Badawy R, Freestone DR, Lai A & Cook MJ. 2012.
Epilepsy: Ever-changing states of cortical excitability.
Neuroscience. 222; 88–99.
st vincent’s research report 2012
174
University of Melbourne Department of Medicine
Badawy R & Jackson G. 2012. Cortical Excitability
inВ Migraine and Epilepsy: A Common Feature?
Journal of Clinical Neurophysiology. 29 (3); 244–249.
Badawy R, Johnson KA, Cook MJ & Harvey . 2012.
A mechanistic appraisal of cognitive dysfunction in
epilepsy. Neuroscience and Biobehavioral Reviews.
36 (8); 1885–1896.
Badawy R, Macdonell R, Vogrin S, Lai A & CookВ MJ.
2012. Cortical excitability decreases in LennoxGastaut syndrome. Epilepsia. 53 (9); 1546–1553.
Barber T, Hofman MSH, Thomson BN & Hicks RJ.
2012. The potential for induction peptide receptor
chemoradionuclide therapy to render inoperable
pancreatic and duodenal neuroendocrine tumours
resectable. European Journal of Surgical Oncology.
38 (1); 64–71.
Barter PJ & Rye K-A. 2012. Cholesteryl ester
transfer protein inhibition as a strategy to reduce
cardiovascular risk. Journal of Lipid Research.
53 (9); 1755–1766.
Barton, Rickels, Alejandro, Hering, Wease,
Naziruddin, Oberholzer, Odorico, Kay TW.
2012. Improvement in Outcomes of Clinical Islet
Transplantation: 1999–2010. Diabetes Care.
34x(7);1436–1445.
Basu A, Alaupovic P, Wu M, Jenkins AJ, Yu Y,
Nankervis AJ, Hanssen KF, Scholz H, Henriksen
T, Lorentzen B, Clausen T, Garg SK, Menard MK,
Hammad SM, Scardo JA, Stanley JR, Dashti A,
Aston CE & Lyons TJ. 2012. Plasma Lipoproteins
and Preeclampsia in Women with Type 1
Diabetes: AВ Prospective Study. Journal of Clinical
Endocrinology & Metabolism. 97 (5); 1752–1762.
Bayles R, Kaipananickal H, Lambert E, Baker EK,
Agrotis A, Guo L, Jowett JBM, Esler M, Lambert
G & El-Osta A. 2012. Epigenetic modification of
the norepinephrine transporter gene in postural
tachycardia syndrome. Arteriosclerosis Thrombosis
and Vascular Biology. 32 (8); 1910–1916.
Beauregard J, Hofman MSH, Kong G & Hicks RJ.
2012. The tumour sink effect on the biodistribution
of Ga-68-DOTA-octreotate: implications for peptide
receptor radionuclide therapy. European Journal
ofВ Nuclear Medicine and Molecular Imaging.
39(1); 50–56.
Benitez-Aguirre, Sasongko M, Craig, Jenkins A,
Cusumano, Cheung DN, Wong TY & Donaghue .
2012. Retinal vascular geometry predicts incident
renal dysfunction in young people with type 1
diabetes. Diabetes Care. 35 (5); 599–604.
Benjamin L, Hedin RH, Koutsoumpas, Ng SC,
Mccarthy E, Prescott J, Pessoa-Lopes, MathewВ G,
Sanderson, Hart L, Kamm MA, Knight C, Forbes,
Stagg J, Lindsay O & Whelan . 2012. Smokers
with active Crohn’s disease have a clinically
relevant dysbiosis of the gastrointestinal microbiota.
Inflammatory Bowel Diseases. 18 (6); 1092–1100.
Bergin, Sadleir, Legros, Mogal, Tripathi,
Dang, Beretta, Zanchi, Burneo, D’Souza WJ,
Wanigasinghe, Tan, Srivastava, Striano, Ossemann,
Cho & Borkowski . 2012. An inernational pilot study
of an internet-based platform to facilitate clinical
researh in epilepsy: The EpiNet project. Epilepsia. 53
(10); 1829–1835.
Best G, Thompson P & Tam CS. 2012. Diagnostic
techniques and therapeutic challenges in patients
with TP53 dysfunctional chronic lymphocytic
leukemia. Leukemia and Lymphoma. 53 (11);
2105–2115.
Best JD, Drury L, Davis ME, Taskinen, Kesaniemi,
Scott, Pardy, Voysey & Keech C. 2012. Glycemic
Control Over 5 Years in 4,900 People With Type 2
Diabetes Real-world diabetes therapy in a clinical
trial cohort. Diabetes Care. 35 (5); 1165–1170.
Bohensky MA, Jolley D, Pilcher DV, Sundararajan
V, Evans S & Brand CA. 2012. Prognostic models
based on administrative data alone inadequately
predict the survival outcomes for critically ill patients
at 180 days post-hospital discharge. Journal of
Critical Care. 27 (4); 422.e11.
Bohensky MA, Sundararajan V, AndrianopoulosВ N,
De Steiger RN, Bucknill A, Kondogiannis CM,
MccollВ GJ & Brand CA. 2012. Trends in elective
knee arthroscopies in a population-based cohort,
2000–2009. Medical Journal of Australia. 197 (7);
399–403.
Borthwick F, Warnakula S, Mangat R, Uwiera RR,
Russell JC, Kelly SE, Lee CY, Hryshko L, Mamo JCL,
Rye K-A, Lopaschuk GD & Proctor SD. 2012. ApoA1 infusion reduces arterial cholesterol and myocardial
lesions in a rat model of cardiac dysfunction and
insulin resistance. Atherosclerosis. 222 (2); 402–408.
st vincent’s research report 2012
175
University of Melbourne Department of Medicine
Brand C, Tropea J, Gorelik A, Jolley D, Scott I &
Sundararajan V. 2012. An adverse event screening
tool based on routinely collected hospital-acquired
diagnoses. International Journal for Quality in Health
Care. 24 (3); 266–278.
Brazionis L, Ting E, Itsiopoulos C, Wilson A &
Hodge A. 2012. The effects of fish or fish oil on the
omega-3 index. Nutrition and Dietetics. 69 (1); 5–12.
Brooks PM, Degenhardt LJ, Marks R, Room RG,
Weintraub RG, Cowie BC & Lopez AD. 2012. A
comparative risk assessment of burden of disease
and injury attributable to 67 risk factors and
risk factor clusters in 21 regions, 1990–2010: a
systematic analysis for the Global Burden of Disease
Study 2010. The Lancet. 380 (9859); 2224–2260.
Broughton SE, Petersen J, Theodossis A,
ScallyВ SW,В Loh KL, Thompson A, Van BergenВ J,
Kooy-WinkelaarВ Y, Henderson KN, Beddoe T,
Tye-Din JA, Mannering SI, Purcell AW, MccluskeyВ J,
Anderson RP, Koning F, Reid HH & RossjohnВ J.
2012. Biased T cell receptor usage directed
against human leukocyte antigen DQ8-restricted
gliadin peptides is associated with celiac disease.
Immunity. 611–621.
Bywater MJ, Poortinga G, Sanij E, Hein N, PeckВ A,
Cullinane C, Wall M, Cluse L, Drygin D, AnderesВ K,
Huser N, Proffitt C, Bliesath J, Haddach M,
Schwaebe M, Ryckman D, Rice W, Schmitt C,
Lowe S, Johnstone RW, Pearson RB, Mcarthur G
&В Hannan RD. 2012. Inhibition of RNA Polymerase
I as a Therapeutic Strategy to Promote CancerSpecific Activation of p53. Cancer Cell. 22; 51–65.
Campbell B, Hornby, Cunninghame, Burns,
MacВ Manus MP, Ryan, Lau WF, Seymour JF &
Wirth A. 2012. Minimising critical organ irradiation
inВ limited stage Hodgkin lymphoma: a dosimetric
study of the benefit of involved node radiotherapy.
Annals of Oncology. 23 (5); 1259–1266.
Campbell DJ. 2012. Angiotensin II generation
inВ vivo: does it involve enzymes other than renin
and angiotensin-converting enzyme? Journal
ofВ theВ Renin-Angiotensin-Aldosterone System.
13 (2); 314–316.
Campbell DJ, Somaratne, Jenkins A, Prior DL, Yii M,
Kenny, Newcomb AE, Schalkwijk, Black & Kelly DJ.
2012. Diastolic Dysfunction of Aging Is Independent
of Myocardial Structure but Associated with Plasma
Advanced Glycation End-Product Level. PLoS One.
7 (11); e49813.
Campbell, Weinberg, Chee, Mariana, Ayala,
Hawthorne, O’Connell, Loudovaris, Cowley,
KayВ TW,В Grey & Thomas H. 2012. Expression ofВ Proand Antiapoptotic Molecules of the Bel-2 Family in
Human Islets Postisolation. CellВ Transplantation. 21
(1); 49–60.
Chaix B, Bean K, Daniel M, Zenk SN, Kestens Y,
Charreire H, Leal C, Thomas F, Karusisi N, Weber C,
Oppert J-M, Simon C, Merlo J & Pannier B. 2012.
Associations of Supermarket Characteristics with
Weight Status and Body Fat: A Multilevel Analysis
ofВ Individuals within Supermarkets (RECORD Study).
PLoS One. 7 (4); e32908.
Clark PJ & Thompson AJ. 2012. Host genomics
and HCV treatment response. Journal of
Gastroenterology and Hepatology. 27 (2); 212–222.
Clark, Thompson AJ, Vock, Kratz, Tolun & Muir.
2012. Hepatitis C Virus Selectively Perturbs the
Distal Cholesterol Synthesis Pathway in a GenotypeSpecific Manner. Hepatology. 56 (1); 49–56.
Clark, Thompson AJ, Zhu, Vock, Ge . 2012.
Interleukin 28B polymorphisms are the only
commonВ genetic variants associated with lowdensity lipoprotein cholesterol (LDL-C) in genotype-1
chronic hepatitis C and determine the association
between LDL-C and treatment response. Journal
of Viral Hepatitis. 19 (5); 332–340.
Coiffier B, Pro B, Prince HM, Foss F, Sokol L,
Greenwood M, Caballero D, Borchmann P,
Morschhauser F, Wilhelm M, Pinter-Brown L,
Padmanabhan S, Shustov A, Nichols J, Carroll S,
Balser J, Balser B & Horwitz S. 2012. Results from
a pivotal, open-label, phase II study of romidepsin
in relapsed or refractory peripheral T-cell lymphoma
after prior systemic therapy. Journal of Clinical
Oncology. 30 (6); 631–636.
Coller J, Campbell DJ, Krum & Prior DL.
2012. Transthoracic echocardiography
findings: Implications for clinical management.
Australian Family Physician. 41 (12); 954–958.
st vincent’s research report 2012
176
University of Melbourne Department of Medicine
Coppieters, Dotta, Amirian, Campbell, KayВ TW,
Atkinson, Roep & Von Herrath . 2012. Demonstration
of islet-autoreactive CD8 T cells inВ insulitic lesions
from recent onset and long-term type 1 diabetes
patients. Journal of Experimental Medicine. 209 (1);
51–60.
Desmond, Gaudieri, Pfafferott, Chopra, Lau,
Audsley, Day, Desmond PV & Thompson AJ. 2012.
Viral Adaptation to Host Immune Responses Occurs
in Chronic Hepatitis B Virus (HBV) Infection, and
Adaptation Is Greatest in HBV e Antigen-Negative
Disease. Journal of Virology. 86 (2); 1181–1192.
Cunningham CBJ, Goodyear BG, Badawy R,
Zaamout F, Pittman D, Beers CA & Federico P. 2012.
Intracranial EEG-fMRI analysis of focal epileptiform
discharges in humans. Epilepsia. 53 (9); 1636–1648.
Dowsey MM, Nikpour M, Dieppe P & ChoongВ PF.
2012. Associations between pre-operative
radiographic changes and outcomes after
total kneeВ joint replacement for osteoarthritis.
Osteoarthritis and Cartilage. 20 (10); 1095–1102.
Cunningham NJ, Weiland TJ, Van Dijk J, Paddle P,
Shilkofski N & Cunningham NY. 2012. Telephone
referrals by junior doctors: a randomised controlled
trial assessing the impact of SBAR in a simulated
setting. Postgraduate Medical Journal. 88 (1045);
619–626.
D’Souza WJ, Quinn SJ, Fryer JL, Taylor BV,
Ficker DM, O’Brien TJ, Pearce N & Cook MJ.
2012.В The prevalence and demographic distribution
of treated epilepsy: a community-based study in
Tasmania, Australia. Acta Neurologica Scandinavica.
125 (2); 96–104.
Davidson PM, Macisaac AI, Cameron J, JeremyВ R,
Mahar L & Anderson I. 2012. Problems, Solutions
andВ Actions: Addressing Barriers in Acute
Hospital Care for Indigenous Australians and
NewВ Zealanders. Heart, Lung and Circulation.
21 (10); 639–643.
De Buck, La Gerche A, Ector, Wielandts, Koopman,
Garweg, Nuyens & Heidbuchel . 2012. Asymmetric
collimation can significantly reduce patient radiation
dose during pulmonary vein isolation. Europace. 14
(3); 437–444.
De Cruz P, Prideaux I, Wagner J, Ng SC,
Mcsweeney C, Kirkwood C, Morrison M
&В KammВ MA. 2012. Characterization of
theВ gastrointestinal microbiota in health
andВ inflammatory bowel disease. Inflammatory
Bowel Diseases. 18 (2); 372–390.
Dendle C, Sundararajan V, Spelman T, Jolley D
&В Woolley I. 2012. Splenectomy sequelae: an
analysis of infectious outcomes among adults
inВ Victoria. Medical Journal of Australia. 196 (9);
582–586.
Efthymiou M, Desmond PV, Brown G, La Nauze R,
Kaffes A, Chua & Taylor AC. 2012. SINGLE-01: a
randomized, controlled trial comparing the efficacy
and depth of insertion of single- and double- balloon
enteroscopy by using a novel method to determine
insertion depth. Gastrointestinal Endoscopy. 76 (5);
972–980.
Emmanuel, Kamm M, Roy, Kerstens &
Vandeplassche. 2012. Randomised clinical trial:
the efficacy of prucalopride in patients with chronic
intestinal pseudo-obstruction - a double-blind,
placebo-controlled, cross-over, multiple n=1 study.
Alimentary Pharmacology and Therapeutics.
35 (1); 48–55.
Fasching PA, Hopper JL, Southey MC, Apicella C,
Giles GG, Severi G, Baglietto L, Phillips K-A, Milne
RL & Schmidt MK. 2012. The role of genetic breast
cancer susceptibility variants as prognostic factors.
Human Molecular Genetics. 21 (17); 3926–3939.
Ferferieva, Van Den Bergh, Claus, Jasaityte,
Veulemans, Pellens, La Gerche A, Rademakers,
Herijgers & D’Hooge . 2012. The relative value
ofВ strain and strain rate for defining intrinsic
myocardial function. American Journal of
Physiology – Heart and Circulatory Physiology.
302 (1); H188–H195.
Fernandez-Cuesta, Oakman, Falagan-Lotsch,
Smoth, Quinaux, Buyse, Dolci, De Azambuja
&В Francis P. 2012. Prognostic and predictive
valueВ ofВ TP53 mutations in node-positive breast
cancer patients treated with anthracycline- or
anthracycline/taxane-based adjuvant therapy:
results from the BIG 02–98 phase III trial.
BreastВ Cancer Research. 14 (3); R70.
st vincent’s research report 2012
177
University of Melbourne Department of Medicine
Fuller, Gauvin, Fournier, Kestens, Daniel M, Morency
& Drouin. 2012. Internal Consistency, Concurrent
Validity and Discriminant Validity of a Measure
of Public Support for Policies for Active Living
in Transportation (PAL-T) in a Population-based
Sample of Adults. Journal of Urban Health. 89 (2);
258–269.
Gauvin L, Richard L, Kestens Y, Shatenstein B,
Daniel M, Moore SD, Mercille G & Payette H.
2012. Living in a Well-Serviced Urban Area Is
Associated With Maintenance of Frequent Walking
Among Seniors in the VoisiNuAge Study. Journals
of Gerontology. Series B: Psychological Sciences
& Social Sciences. 67 (1); 76–88.
Georgy S, Pagel CN, Ghasem Zadeh A, Zebaze D,
Pike RN, Sims NA & Mackie EJ. 2012. Proteinaseactivated receptor-2 is required for normal osteoblast
and osteoclast differentiation during skeletal growth
and repair. Bone. 50; 704–712.
Gilbert RE, Zhang Y, Williams SJ, Zammit S,
Stapleton DI, Cox AJ, Krum H, Langham RG
&В KellyВ DJ. 2012. A purpose-Synthesised AntiFibrotic Agent Attenuates Experimental Kidney
Diseases in the Rat. PLoS One. 7 (10); e47160.
Goodwin P, Phillips K, West D, Ennis E, HopperВ J,
John E, O’Malley F, Milne RL, Andrulis I,
Friedlander M, Southey M, Apicella C, Giles G
& Longacre T. 2012. Breast Cancer Prognosis
in BRCA1 and BRCA2 Mutation Carriers:
AnВ International Prospective Breast Cancer
Family Registry Population-Based Cohort Study.
Journal of Clinical Oncology. 30 (1); 19–26.
Graham KL, Krishnamurthy B, Fynch S,
Ayala-PerezВ R, Slattery RM, Santamaria
P, ThomasВ HE & Kay TWH. 2012. Intraislet proliferation of cytotoxic T lymphocytes
contributesВ to insulitis progression. European
Journal of Immunology. 42 (7); 1717–1722.
Halliday AJ, Moulton, Wallace & Cook MJ. 2012. Novel
methods of antiepileptic drug delivery – Polymerbased implants. Advanced Drug Delivery Reviews.
64 (10); 953–964.
Halliday, Campbell, Razal, Mclean, Nelson,
CookВ MJВ & Wallace . 2012. In vivo biocompatibility
and inВ vitro characterization of poly-lactide-coglycolide structures containing Levetiracetam for
the treatment of epilepsy. Journal of Biomedical
Materials Research Part A. 100A (2); 424–431.
Hofferberth S, Foley PT, Newcomb AE, Yap KK,
Yii MY, Nixon IK, Wilson AM & Mossop PJ. 2012.
Combined Proximal Endografting With Distal BareMetal Stenting for Management of Aortic Dissection.
Annals of Thoracic Surgery. 93 (1); 95–102.
Hofferberth S, Newcomb AE, Ryan MC,
Yii MY,В Nixon IK, Rosalion A, Boston RC,
WardВ GM, WilsonВ AM. 2012. High Incidence
ofВ Insulin Resistance and Dysglycemia
AmongstВ NondiabeticВ Cardiac Surgical Patients.
Annals of Thoracic Surgery. 94 (1); 117–122.
Hofferberth S, Newcomb AE, Yii MY, Yap KK,
Boston RC, Nixon IK & Mossop PJ. 2012.
CombinedВ proximal stent grafting plus distal bare
metal stenting for management of aortic dissection:
Superior to standard endovascular repair? Journal
of Thoracic and Cardiovascular Surgery. 144 (4);
956–962.
Hsiao ST, Asgari A, Lokmic Z, Sinclair RD,
DustingВ GJ, Lim SY & Dilley RJ. 2012. Comparative
analysis of paracrine factor expression in human
adult mesenchymal stem cells derived from bone
marrow, adipose, and dermal tissue. Stem Cells
and Development. 21 (12); 2189–2203.
Hsu, Chen, Liu GS, Tai, Wang, Wu J-C, Kung,
ChanВ EC & Liu . 2012. Tumorigenesis and
prognosticВ role of hepatoma-derived growth factor
inВ human gliomas. Journal of Neuro-Oncology.
107 (1); 101–109.
Hudson PL, Lobb EA, Thomas K, Trauer T,
QuinnВ K, Williams A & Summers M. 2012. PsychoEducational Group Intervention for Family Caregivers
of Hospitalized Palliative Care Patients: Pilot Study.
Journal of Palliative Medicine. 15 (3); 277–281.
Hudson PL, Remedios CM, Zordan RD,
CliftonВ D, Crewdson MJ, Hall C, Trauer T,
BolleterВ A,В ClarkeВ DM & Bauld C. 2012.
GuidelinesВ forВ theВ psychosocial and bereavement
support of family caregivers of palliative care
patients. Journal of Palliative Medicine.
15 (6);  696–702.
st vincent’s research report 2012
178
University of Melbourne Department of Medicine
Hudson PL, Trauer T, Lobb E, Zordan RD,
WilliamsВ A, Quinn K, Summers M & Thomas K.
2012. Supporting family caregivers of hospitalised
palliative care patients: a psychoeducational group
intervention. BMJ Supportive and Palliative care.
2 (2); 115–120.
Joffe, Necula, Chand, Mcwhinney, Krishnamurthy
B, Loudovaris, Goodman DJ, Thomas H, Kay TW
&В Mannering SI. 2012. Residual methylprednisolone
suppresses human T-cell responses to spleen, but
not islet, extracts from deceased organ donors.
International Immunology. 24 (7); 447–453.
Huttinger ZM, Milks MW, Nickoli MS, AurandВ WL,
Long LC, Wheeler DG, Dwyer KM, D’Apice AJ,
Robson SC, Cowan PJ & Gumina RJ. 2012.
Ectonucleotide Triphosphate Diphosphohydrolase-1
(CD39) Mediates Resistance to Occlusive Arterial
Thrombus Formation after Vascular Injury in Mice.
American Journal of Pathology. 181 (1); 322–333.
Johnson, Brown, Clarke, Boudville, Elias &
Langham RG. 2012. The effect of low glucose
degradation product, neutral pH versus standard
peritoneal dialysis solutions on peritoneal membrane
function: the balANZ trial. Nephrology, Dialysis,
Transplantation. 27; 4445–4453.
Iland H, Bradstock K, Supple S, Catalano A,
CollinsВ M, Hertzberg M, Browett P, Grigg AP,
FirkinВ FC, Hugman A, Reynolds J, Di Iulio J,
TileyВ C,В Taylor K, Filshie RJ, Seldon M, Taper J,
SzerВ J, Moore J, Bashford J & Seymour JF. 2012.
All-trans-retinoic acid, idarubicin, and IV arsenic
trioxide as initial therapy in acute promyelocytic
leukemia (APML4). Blood. 120 (8); 1570–1580.
Januszewski AS, Sachithanandan N, Karschimkus
C, O’Neal DN, Yeung C, Alkatib & Jenkins A. 2012.
Non-invasive measures of tissue autofluorescence
are increased in Type 1 diabetes complications and
correlate with a non-invasive measure of vascular
dysfunction. Diabetic Medicine. 29 (6); 726–733.
Jazwinski, Thompson AJ, Clark, Naggie, Tillmann &
Patel . 2012. Elevated serum CK18 levels in chronic
hepatitis C patients are associated with advanced
fibrosis but not steatosis. Journal of Viral Hepatitis.
19 (4); 278–282.
Jelinek GA, Marck CH, Weiland TJ, Neate SL &
Hickey B. 2012. Organ and tissue donation-related
attitudes, education and practices of emergency
department clinicians in Australia. Emergency
Medicine Australasia. 24 (3); 244–250.
Jenkins MJ, Edgley AJ, Sonobe T, Umetani K,
Schwenke DO, Fujii Y, Brown RD, Kelly DJ, Shirai M
& Pearson JT. 2012. Dynamic Synchrotron Imaging
of Diabetic Rat Coronary Microcirculation In Vivo.
Arteriosclerosis Thrombosis and Vascular Biology.
32 (2); 370–377.
Jerums G, Ekinci EI, Panagiotopoulos S &
MacisaacВ RJ. 2012. Early Glomerular Filtration
RateВ Loss as a Marker of Diabetic Nephropathy.
European Nephrology. 6 (1); 33–37.
Johnson, Brown, Clarke, Boudville, Elias &
LanghamВ RG. 2012. The effects of Biocompatible
ompared with Standard Peritoneal Dialysis
Solutions on Peritonitis Microbiology, Treatment,
and Outcomes: the BalANZ Trial. Peritoneal
Dialysis International. 32 (5); 497–506.
Johnson DW, Brown FG, Clarke M, BoudvilleВ N,
EliasВ TJ, Foo MWY, Jones B, Kulkarni H,
LanghamВ R, Ranganathan D, Schollum J,
SuranyiВ M,В Tan SH & Voss D. 2012. Effects
ofВ Biocompatible versus Standard Fluid
onВ PeritonealВ Dialysis Outcomes. Journal
ofВ theВ American Society of Nephrology.
23 (6); 1097–1107.
Jones K, Nourse JP, Keane C, Crooks P,
GottliebВ D,В Ritchie DS, Gill D & Gandhi MK.
2012. Tumor-specific but not nonspecific cellfreeВ circulating DNA can be used to monitor
diseaseВ response in lymphoma. American
Journal of Hematology. 87 (3); 258–265.
Jurado S, Conlan LA, Baker EK, Ng J-L,
TenisВ N,В Hoch NC, Gleeson K, Smeets M,
IzonВ DВ &В Heierhorst J. 2012. ATM Substrate
Chk2-interacting Zn2+ Finger (ASCIZ) Is a
Bi-functional Transcriptional Activator and
FeedbackВ Sensor in the Regulation of Dynein
LightВ Chain (DYNLL1) Expression. Journal
of Biological Chemistry. 287 (5); 3156–3164.
Jurado S, Gleeson K, O’Donnell K, Izon DJ,
WalkleyВ CR, Strasser A, Tarlinton DM & HeierhorstВ J.
2012. The Zinc-finger protein ASCIZ regulates B
cell development via DYNLL1 and Bim. Journal
of Experimental Medicine. 209 (9); 1629–1639.
st vincent’s research report 2012
179
University of Melbourne Department of Medicine
Khong SML, Andrews KL, Huynh NN, VenardosВ K,
Aprico A, Michell DL, Zarei M, Moe KT, Dusting GJ,
Kaye DM & Chin-Dusting JPF. 2012. Arginase II
inhibition prevents nitrate tolerance. British Journal
of Pharmacology. 166 (7); 2015–2023.
Koay KK, Schofield PE & Jefford MH. 2012.
Importance of health literacy in oncology. AsiaPacific Journal of Clinical Oncology. 8 (1); 14–23.
Lee K, Lee KFE, Lu B, Roussel JC, Murray-Segal
LJ, Salvaris EJ, Hodgkinson SJ, Hall BM, D’Apice
AJ, Cowan PJ & Gock H. 2012. Protective Effects
ofВ Transgenic Human Endothelial Protein C Receptor
Expression in Murine Models of Transplantation.
American Journal of Transplantation. 12 (9);
2363–2372.
Kumari SR, Badwaik R, Sundararajan V &
Jayaraman VK. 2012. Defensinpred: Defensin
and Defensin Types Prediction Server. Protein
and Peptide Letters. 19 (12); 1318–1323.
Lekawanvijit, Kompa A, Manabe, Wang,
LanghamВ RG, Nishijima, Kelly DJ & Krum H. 2012.
Chronic Kidney Disease-Induced Cardiac Fibrosis
Is Ameliorated by Reducing Circulating Levels
ofВ aВ Non-Dialysable Uremic Toxin, Indoxyl Sulfate.
PLoS One. 7 (7); e41281–e41281.
La Gerche A, Burns AT, D’Hooge, Macisaac AI,
Heidbuchel H & Prior DL. 2012. Exercise strain
rate imaging demonstrates normal right ventricular
contractile reserve and clarifies ambiguous resting
measures in endurance athletes. Journal of the
American Society of Echocardiography. 25 (3);
253–262.e1.
Lekawanvijit, Kompa A, Zhang Y, Wang, Kelly DJ &
Krum H. 2012. Myocardial infarction impairs renal
function, induces renal interstitial fibrosis, and
increases renal KIM-1 expression: implications for
cardiorenal sydrome. American Journal of Physiology
- Heart and Circulatory Physiology. 302 (9); H1884–
H1893.
La Gerche A, Burns AT, Taylor, Macisaac AI,
Heidbuchel & Prior DL. 2012. Maximal oxygen
consumption is best predicted by measures of
cardiac size rather than function in healthy adults.
European Journal of Applied Physiology. 112 (6);
2139–2147.
Leontovich AA, Dronca RS, Suman VJ, AshdownВ M,
Nevala WK, Thompson MA, Robinson AP,
Kottschade LA, Kaur JS, Mcwilliams RR, Ivanov LV,
Croghan GA & Markovic SN. 2012. Fluctuation of
systemic immunity in melanoma and implications
for timing of therapy. Frontiers in Bioscience.
E4 (3); 958–975.
La Gerche A, Burns, Mooney DJ, Inder WJ, Tay,
Bogaert J, Macisaac AI, Heidbuchel H & Prior DL.
2012. Exercise-induced right ventricular dysfunction
and structural remodelling in endurance athletes.
European Heart Journal. 33 (8); 998–1006.
Layland JJ, Macisaac AI, Burns AT, Somaratne
B, Leitl, Whitbourn RJ & Wilson AM. 2012. When
Collateral Supply is Accounted For Epicardial
Stenosis Does Not Increase Microvascular
Resistance. Circulation. Cardiovascular
Interventions. 5 (1); 97–102.
Layland JJ, Whitbourn RJ, Burns AT, Somaratne J,
Leitl G, Macisaac AI & Wilson A. 2012. The index
of microvascular resistance identifies patients with
periprocedural myocardial infarction in elective
percutaneous coronary intervention. Heart. 98 (20);
1492–1497.
Livingston PM, Craike M & Slavin M. 2012. Clinical
and Economic Burden of Emergency Department
Presentations for Neutropenia Following Outpatient
Chemotherapy for Cancer in Victoria, Australia.
The Oncologist. 17 (7); 998–1004.
Lopes-Virella, Baker, Hunt, Lyons, Jenkins A &
Virella . 2012. High Concentrations of AGE-LDL
andВ Oxidized LDL in Circulating Immune Complexes
Are Associated With Progression of Retinopathy in
Type 1 Diabetes. Diabetes Care. 35 (6); 1333–1340.
Lozano, Cowie BC, Degenhardt LJ, Marks R,
SteerВ AC, Weintraub RG, Lopez AD & Murray JL.
2012. Global and regional mortality from 235 causes
of death for 20 age groups in 1990 and 2010: a
systematic analysis for the Global Burden of Disease
Study 2010. The Lancet. 380 (9859); 2095–2128.
Layland JJ, Whitbourn R, Macisaac AI, Somaratne
J & Wilson AM. 2012. Takotsubo cardiomyopathy:
reversible elevation in microcirculatory resistance.
Cardiovascular Revascularization Medicine.
13 (1); 66–68.
st vincent’s research report 2012
180
University of Melbourne Department of Medicine
Lu L, Sun Y, Nombela-Arrieta C, Du KP, ParkВ S-Y,
Chai L, Walkley C, Luo HR & Silberstein LE.
2012. Fak depletion in both hematopoietic and
nonhematopoietic niche cells leads to hematopoietic
stem cell expansion. Experimental Hematology.
40 (4); 307–317.
Millington, Jones LN & Sinclair RD. 2012.
Chemiluminescence from UVA-exposed skin:
Separating photo-induced chemiluminescence
from photophysical light emission. Journal of
Photochemistry and Photobiology B – Biology.
114; 140–146.
Mackinnon RN, Selan C, Zordan A, Wall M,
Nandurkar H & Campbell LJ. 2012. CGH and SNP
array using DNA extracted from fixed cytogenetic
preparations and long-term refrigerated bone
marrow specimens. Molecular Cytogenetics.
5В (10);В 10.
Mohamed Ali M, Royse AG, Connelly KA &
RoyseВ CF. 2012. The accuracy of transoesophageal
echocardiography in estimating pulmonary
capillary wedge pressure in anaesthetised patients.
Anaesthesia. 67; 122–131.
Marck CH, Weiland TJ, Neate SL, Hickey BB
& Jelinek GA. 2012. Australian emergency
doctors’ and nurses’ acceptance and knowledge
regarding brain death: a national survey.
Clinical Transplantation. 26 (3); E254–E260.
Marck, Weiland TJ, Neate, Hickey & Jelinek GA.
2012. Personal attitudes and beliefs regarding
organВ and tissue donation: a cross-sectional
surveyВ of Australian emergency department
clinicians. Progress in Transplantation. 22 (3);
317–322.
Matzelle MM, Gallant MA, Condon KW, WalshВ NC,
Manning CA, Stein GS, Lian JB, Burr DB &
Gravallese EM. 2012. Resolution of inflammation
induces osteoblast function and regulates the Wnt
signaling pathway. Arthritis and Rheumatism. 64 (5);
1540–1550.
Meiser, Price, Butow, Karatas, Wilson, Heiniger,
Baylock, Charles, Mclachlan S & Phillips K. 2012.
Psychosocial factors and uptake of risk-reducing
salpingo-oophorectomy in women at high risk.
Familial Cancer. 12 (1); 101–109.
Mercille G, Richard L, Gauvin L, Kestens Y,
Shatenstein B, Daniel M & Payette H. 2012.
Associations between residential food environment
and dietary patterns in urban-dwelling older adults:
results from the VoisiNuAge study. Public Health
Nutrition. 15 (11); 2026–2039.
Michael M, Cullinane C, Hatzimihalis A, O’Kane C,
Milner A, Booth R, Schlicht S, ClarkeВ S &
FrancisВ P. 2012. Docetaxel pharmacokinetics
andВ itsВ correlation with two in vivo probes for
cytochrome P450 enzymes: the C-14-erythromycin
breath test and the antipyrine clearance test. Cancer
Chemotherapy and Pharmacology. 69 (1); 125–135.
Mollah Z, Graham K, Krishnamurthy B,
TrivediВ PM,В Brodnicki TC, Trapani JA, Kay TW
&В ThomasВ H. 2012. Granzyme B Is Dispensable
inВ the Development of Diabetes in Non-Obese
Diabetic Mice. PLoS One. 7 (7); e40357.
Moore G, Hepworth G, Weiland T, Manias E,
GerdtzВ MF, Kelaher M & Dunt D. 2012. Prospective
validation of a predictive model that identifies
homeless people at risk of re-presentation
to theВ emergency department. Australasian
Emergency Nursing Journal. 15 (1); 2–13.
Mount, Gleich, Tam, Choy S, Dwyer K, Lu,
VanВ Denderen BJ, Fingerle-Rowson, Bucala,
PowerВ DA & Kemp BE. 2012. The Outcome
ofВ RenalВ Ischemia-Reperfusion Injury Is
UnchangedВ in AMPK-Гџ1 Deficient Mice.
PLoSВ One.В 7 (1); e29887.
Naggie, Osinusi, Katsounas, Lempicki, Herrmann
& Thompson AJ. 2012. Dysregulation of Innate
Immunity in Hepatitis C Virus Genotype 1 IL28BUnfavourable Genotype Patients: Impaired Viral
Kinetics and Therapeutic Response. Hepatology.
56 (2); 444–454.
Naggie, Osinusi, Katsounas, Lempicki, Herrmann
& Thompson AJ. 2012. The Association of Genetic
Variants with Hepatic Steatosis in Patients with
Genotype 1 Chronic Hepatitis C Infection. Digestive
Diseases and Sciences. 57 (8); 2213–3321.
Nanavati SP, Sundararajan V, Mahamuni S,
GhaisasВ SV & Kumar V. 2012. Nonstoichiometric
Mn-doped ZnO magic nanoclusters and their
composite structures from ab initio calculations.
Physical Review B. 86 (20); 205320.
st vincent’s research report 2012
181
University of Melbourne Department of Medicine
Neate SL, Marck CH, Weiland TJ, Cunningham N,
Hickey B, Dwyer BM & Jelinek GA. 2012. Australian
emergency clinicians’ perceptions and use of the
GIVE Clinical Trigger for identification of potential
organ and tissue donors. Emergency Medicine
Australasia. 24 (5); 501–509.
Patel SK, Wai B, Macisaac RJ, Grant SL,
VelkoskaВ E, Ord M, Panagiotopoulos S, Jerums G,
Srivastava P & Burrell LM. 2012. The CTGF gene
-945 G/C polymorphism is not associated with
cardiac or kidney complications in subjects with type
2 diabetes. Cardiovascular Diabetology. 11 (1); 42.
Ngan SY, Burmeister B, Fisher RJ, Solomon M,
Goldstein D, Joseph D, Ackland SP, Schache D,
Mcclure B, Mclachlan S-A, Mckendrick J, Leong
T, Hartopeanu C, Zalcberg J & Mackay J. 2012.
Randomized Trial of Short-Course Radiotherapy
Versus Long-Course Chemoradiation Comparing
Rates of Local Recurrence in Patients With T3
Rectal Cancer: Trans-Tasman Radiation Oncology
Group Trial 01.04. Journal of Clinical Oncology.
30 (31); 3827–3833.
Peate M, Meiser B, Cheah B, Saunders C, ButowВ P,
Hart R, Phillips K, Hickey M & Friedlander M.
2012. Making hard choices easier: a prospective,
multicentre study to assess the efficacy of a
fertility-related decision aid in young women
withВ early-stage breast cancer. British Journal
of Cancer. 106 (6); 1053–1061.
Ohishi M, Ono W, Ono N, Khatri R, Marzia M,
Baker EK, Root SH, Wilson TL-, Iwamototo Y,
Kronenberg HM, Aguila HL, Purton LE & Schipani
E. 2012. A Novel Population of Cells Expressing
Both Hematopoietic and Mesenchymal Markers
IsВ PresentВ in the Normal Adult Bone Marrow and
IsВ Augmented in a Murine Model of Marrow Fibrosis.
American Journal of Pathology. 180 (2); 811–818.
Peel TN, Cheng AC, Choong PFM & Buising KL.
2012. Early onset prosthetic hip and knee joint
infection: treatment and outcomes in Victoria,
Australia. Journal of Hospital Infection. 82 (4);
248–253.
Peel TN, Cheng C, Buising KL & Choong PF.
2012. Microbiological Aetiology, Epidemiology,
andВ ClinicalВ Profile of Prosthetic Joint Infections:
AreВ Current Antibiotic Prophylaxis Guidelines
Effective? Antimicrobial Agents and Chemotherapy.
56 (5); 2386–2391.
Ong FS, Lin CX, Campbell DJ, OkwanDuoduВ D, Chen X, Blackwell W-L, Shah KH,
Gonzalez-Villalobos RA, Shen XZ, Fuchs S &
BernsteinВ KE. 2012. Increased Angiotensin IIInduced Hypertension and Inflammatory Cytokines
inВ MiceВ Lacking Angiotensin-Converting Enzyme N
Domain Activity. Hypertension. 59 (2); 283–290.
Peletier, Guimont-Desrochers, Ashton MP,
BrodnickiВ C & Lesage . 2012. The Size of the
Plasmacytoid Dendritic Cell Compartment Is a
Multigenic Trait Dominated by a Locus on Mouse
Chromosome 7. Journal of Immunology. 188 (11);
5561–5570.
Ong, Rye K, O’Connell, Jenkins A, Brown,
Xu, Sullivan, Barter & Keech . 2012. LongTerm Fenofibrate Therapy Increases Fibroblast
GrowthВ Factor 21 and Retinol-Binding Protein 4
inВ Subjects with Type 2 Diabetes. Journal of Clinical
Endocrinology & Metabolism. 97 (12); 4701–4708.
Peyrin-Biroulet, Cieza, Sandborn, Coenen, Chowers,
Hibi, Kostanjsek, Stucki, Colombel & Kamm M.
2012. Development of the first disability index
for inflammatory bowel disease based on the
international classificaiton of functioning, disability
and health. Gut. 61 (2); 241–247.
Palanivel RP, Fullerton MDF, Galic SG,
HoneymanВ JE, Hewitt K, Jorgensen SBJ &
SteinbergВ G. 2012. Reduced Socs3 expression
inВ adipose tissue protects female mice against
obesity-induced insulin resistance. Diabetologia.
55 (11); 3083–3093.(Not Final)
Philip J, Gold M, Brand C, Douglass J, Miller B &
Sundararajan. 2012. Negotiating hope with chronic
obstructive pulmonary disease patients: a qualitative
study of patients and healthcare professionals.
Internal Medicine Journal. 42 (7); 816–822.
Paratz ED & Flynn E. 2012. Rapid death after
admission to palliative care. Internal Medicine
Journal. 42 (9); 984–989.
Phillips GA, Hendrie J, Atua V & Manineng C. 2012.
Capacity building in emergency care: An example
from Madang, Papua New Guinea. Emergency
Medicine Australasia. 24 (5); 547–552.
st vincent’s research report 2012
182
University of Melbourne Department of Medicine
Poulton IJ, Mcgregor NE, Pompolo S, Walker EC
& Sims NA. 2012. Contrasting roles of leukemia
inhibitory factor in murine bone development
and remodeling involve region-specific changes
in vascularization. Journal of Bone and Mineral
Research. 27 (3); 586–595.
Prideaux I, Kamm M, De Cruz P, Williams, Bell S,
Connell WR, Brown SJ, Lust M, Desmond PV,
LeongВ W, Wu CY, Chow KL, Chan, Ng S, Chan F &
Sung J. 2012. Comparison of clinical characteristics
and management of inflammatory bowel disease
in Hong Kong versus Melbourne. Journal of
Gastroenterology and Hepatology. 27 (5); 919–927.
Prideaux L, Kamm MA, De Cruz PP, Chan FKL,
NgВ SC. 2012. Inflammatory bowel disease in Asia:
AВ systematic review. Journal of Gastroenterology
and Hepatology. 27 (8); 1266–1280.
Prior DL & La Gerche A. 2012. The athlete’s heart.
Heart. 98 (12); 947–955.
Prudent R, Vassal-Stermann E, Chi-HungВ N,
PilletВ C, Martinez A, Prunier C, Barette C,
SoleilhacВ E,В FilholВ O, Beghin A, Valdameri G,
Honore S, Aci-Seche S, Grierson D, Antonipillai J,
Li R, Di Pietro A, Dumontet C, Braguer D, Florent
J-C, Knapp S, Bernard O & Lafanechere L. 2012.
Pharmacological Inhibition of LIM Kinase Stabilizes
Microtubules and Inhibits Neoplastic Growth.
Cancer Research. 72 (17); 4429–4439.
Ratnam D, Dev A, Nguyen T, Sundararajan V,
Harley H, Cheng W, Lee A, Rusli F, Chen R, BellВ S,
Pianko S & Sievert W. 2012. Efficacy and tolerability
of pegylated interferon-О±-2a in chronic hepatitis
B: A multicenter clinical experience. Journal
ofВ Gastroenterology and Hepatology. 27 (9);
1447–1453.
Remond, Wheaton, Walsh, Prior DL & Maguire .
2012. Acute Rheumatic Fever and Rheumatic Heart
Disease - Priorities in Prevention, Diagnosis and
Management. A Report of the CSANZ Indigenous
Cardiovascular Health Converence, Alice Springs
2011. Heart, Lung & Circulation. 21 (10); 632–638.
Rufaut NW, Goldthorpe NT, Craven J, Wallace AM,
Wildermoth E & Nixon AJ. 2012. The germinative
epithelium of sheep vibrissae and wool follicles has
extensive proliferative potential but is dependent
on the dermal papilla. International Journal of
Trichology. 4 (2); 75–82.
Rye K-A & Barter PJ. 2012. The inhibition of
cholesteryl ester transfer protein: a long and winding
road. Journal of Lipid Research. 53 (6); 1039–1041.
Saddik D, Tran P, Troupis J, Tirman P, O’Donnell J,
Howells R, Farish S & Tartaglia C. 2012. Are extralabral MR findings useful in the diagnosis of a labral
tear? Journal of Medical Imaging and Radiation
Oncology. 56 (3); 255–260.
Sadowski, Suryadinata R, Tan A, Binte Roesley S
&В Sarcevic B. 2012. Protein monoubiquitination
andВ polyubiquitination generate structural diversity
toВ control distinct biological processes. IUBMB Life.
64 (2); 136–142.
Sanders LM, Srikanth VK, Jolley DJ, SundararajanВ V,
Psihogios H, Wong K, Ramsay D & Phan TG.В 2012.
Monash Transient Ischemic Attack Triaging
Treatment: Safety of a Transient Ischemic Attack
Mechanism-Based Outpatient Model of Care.
Stroke. 43 (11); 2936–2941.
Sasongko MB, Wong TY, Donaghue KC, CheungВ N,
Jenkins AJ, Benitez-Aguirre P & Wang JJ. 2012.
Retinal Arteriolar Tortuosity is Associated With
Retinopathy and Early Kidney Dysfunction in Type
1 Diabetes. American Journal of Ophthalmology.
153 (1); 176–183.
Sasongko MB, Wong TY, Nguyen TT, ShawВ JE,
Jenkins AJ & Wang JJ. 2012. Novel versus
traditional risk markers for diabetic retinopathy.
Diabetologia. 55 (3); 666–670.
Sasongko M, Wong TY, Nguyen TT, Kawasaki R,
Jenkins A, Shaw J, Robinson C & Wang JJ. 2012.
Serum apolipoproteins are associated with systemic
and retinal microvascular function in people with
diabetes. Diabetes. 61 (7); 1785–1792.
Schofield A, Steel R & Bernard O. 2012. Rhoassociated coiled-coil kinase (ROCK) protein
controls microtubule dynamics in a novel signaling
pathway that regulates cell migration. Journal
of Biological Chemistry. 287 (52); 43620–43629.
Seneviratne U, Cook MJ & D’Souza WJ. 2012.
TheВ electroencephalogram of idiopathic generalized
epilepsy. Epilepsia. 53 (2); 234–248.
Seneviratne U, Cook MJ & D’Souza WJ. 2012.
The prognosis of idiopathic generalized epilepsy.
Epilepsia. 53 (12); 2079–2090.
st vincent’s research report 2012
183
University of Melbourne Department of Medicine
Sims NA & Chia L. 2012. Regulation of sclerostin
expression by paracrine and endocrine factors.
Clinical Reviews in Bone and Mineral Metabolism.
10 (2); 98–107.
Thompson AJ, Clark, Singh, Ge, Fellay & Zhu .
2012. Genome-wide association study of interferonrelated cytopenia in chronic hepatitis C patients.
Journal of Hepatology. 56 (2); 313–319.
Sims NA & Walsh NC. 2012. Intercellular Cross-Talk
Among Bone Cells: New Factors and Pathways.
Current Osteoarthritis Reports. 10 (2); 109–117.
Thompson AJ, Patel, Chuang, Lawitz & RodriguezTorres . 2012. Viral clearance is associated with
improved insulin resistance in genotype 1 chronic
hepatitis C but not genotype 2/3. Hepatology.
61 (6); 128–134.
Sinclair R. 2012. Skin checks. Australian
Family Physician. 41 (7); 464–469.
Sinclair R, Flagler, Jones LN, Rufaut NW & Davis G.
2012. The proteomic profile of hair damage. British
Journal of Dermatology. 166 (Suppl.2); 27–32.
Smalley KSM & Mcarthur GA. 2012. The
CurrentВ State of Targeted Therapy in Melanoma:
This Time It’s Personal. Seminars in Oncology.
39 (2); 204–214.
So, Macisaac RJ & Grossmann M. 2012.
Hypothyroidism Investigation and management.
Australian Family Physician. 41 (8); 556–562.
Steinfort DP, Russell PA, Tsui A, White G, WrightВ G
& Irving LB. 2012. Interobserver agreement in
determining non-small cell lung cancer subtype
inВ specimens acquired by EBUS-TBNA. European
Respiratory Journal. 40 (3); 699–705.
Stewart EM, Liu X, Clark GM, Kapsa RMI &
WallaceВ GG. 2012. Inhibition of smooth muscle
cell adhesion and proliferation on heparin-doped
polypyrrole. Acta Biomaterialia. 8 (1); 194–200.
Tan, Sinclair & Foley PA. 2012. Running behind
a tourist: leisure–related skin cancer prophylaxis.
British Journal of Dermatology. 167 (Suppl.2); 70–75.
Tan SM, Zhang Y, Wang, Tan CY, Zammit S,
WilliamsВ SJ, Krum H & Kelly DJ. 2012. FT23,
anВ orally active antifibrotic compound, attenuates
structural and functional abnormalities in an
experimental model of diabetic cardiomyopathy.
Clinical and Experimental Pharmacology and
Physiology. 39 (8); 650–656.
Thakkar V, Moore OA, Stevens W & Nikpour M.
2012. Managing scleroderma: Challenges in
primary care. Medicine Today. 35–42.(Not Final)
Thompson AJ. 2012. Genetic Factors and
HepatitisВ C Virus Infection. Gastroenterology.
142 (6); 1335–1339.
Thompson AJ & Patel K. 2012. New agents
forВ theВ treatment of hepatitis C virus - Focus
onВ telaprevir. Virus Adaption and Treatment.
4 (1); 75–84.
Ting, Keech, Drury, Donoghoe, Hedley, Jenkins
A, Lehto, Celermajer, Simes, Staton & Rajamani .
2012. Benefits and Safety of Long-Term Fenofibrate
Therapy in People With Type 2 Diabetes and Renal
Impairment. Diabetes Care. 35 (2); 218–225.
Tropea J, Sundararajan V, Gorelik A, Kennedy M,
Cameron P & Brand CA. 2012. Patients who leave
without being seen in emergency departments:
an analysis of predictive factors and outcomes.
Academic Emergency Medicine. 19 (4); 439–447.
Tso C, Rye K-A & Barter P. 2012. Phenotypic and
Functional Changes in Blood Monocytes Following
Adherence to Endothelium. PLoS One. 7 (5);
e37091.
Van Hulst, Barnett A, Gauvin, Daniel M, Kestens,
Bird, Gray-Donald & Lambert . 2012. Associations
Between Children’s Diets and Features of Their
Residential and School Neighbourhood Food
Environments. Canadian Journal of Public Health.
103 (suppl 3); s48–s54.
Veldt, Duarte-Rojo, Thompson AJ, Watt, Heimbach
& Tillmann . 2012. Recipient IL28B Polymorphism
Is an Important Independent Predictor of
Posttransplant Diabetes Mellitus in Liver Transplant
Patients With Chronic Hepatitis C. American
Journal of Transplantation. 12 (3); 737–744.
Viry, Moulton, Romeo T, Suhr, Mawad, Cook MJ &
Wallace . 2012. Emulsion-coaxial electrospinning:
designing novel architectures for sustained release
ofВ highly soluble low molecular weight drugs. Journal
of Materials Chemistry. 22 (22); 11347–11353.
st vincent’s research report 2012
184
University of Melbourne Department of Medicine
Walker EC, Poulton IJ, Mcgregor NE, Ho PWM,
Allan EH, Quach JM, Martin TJ & Sims NA. 2012.
Sustained RANKL response to parathyroid hormone
in oncostatin M receptor-deficient osteoblasts
converts anabolic treatment to a catabolic effect
inВ vivo. Journal of Bone and Mineral Research.
27 (4); 902–912.
Winkler IG, Pettit AR, Raggatt LJ, JacobsenВ RN,
Forristal CE, Barbier V, Nowlan B, Cisterne A,
Bendall LJ, Sims NA & Levesque J-P. 2012.
Hematopoietic stem cell mobilizing agents G-CSF,
cyclophosphamide or AMD3100 have distinct
mechanisms of action on bone marrow HSC niches
and bone formation. Leukemia. 26 (7); 1594–1601.
Walkley CR, Liddicoat B & Hartner JC. 2012. Role
of ADARs in mouse development. Current Topics
in Microbiology and Immunology. 353 (1); 197–220.
Wong, Weiland TJ & Jelinek GA. 2012.
Emergency clinicians’ attitudes and decisions
inВ patient scenarios involving advance directives.
Emergency Medicine Journal. 29 (9); 720–724.
Wang, Mcrae, Robson, Cowan PJ, Zhang, Hu,
Polhill, Zheng, Alexander, Dwyer K, Harris, Unwin,
Lee . 2012. Regulatory T cells participate in CD39mediated protection from renal injury. European
Journal of Immunology. 422 (1); 2441–2451.
Weber B, Burns WI, Snyder RD, Newnham GM,
Mclachlan S-A, Liew D & Dowling AJ. 2012. A
retrospective cohort study of metastatic colorectal
cancer patients treated with oxaliplatin-based
chemotherapy, with an exploratory analysis of
changing serum carcinoembryonic antigen levels.
Asia Pacific Journal of Clinical Oncology. 8 (2);
172–179.
Weiland TJ, Nguyen M & Jelinek GA. 2012.
Illness perception and knowledge with regard
toВ prediabetes and type 2 diabetes: a pilot
study ofВ emergency department patients and
staff. European Journal of emergency Medicine.
19 (6); 353–358.
Wheeler DG, Joseph ME, Mahamud SD,
AurandВ WL, Mohler PJ, Pompili VJ, Dwyer KM,
Nottle MB, Harrison, D’Apice AJ, Robson SC,
Cowan PJ & Gumina RJ. 2012. Transgenic swine:
expression of human CD39 protects against
myocardial injury. Journal of Molecular and
Cellular Cardiology. 52 (5); 958–961.
Williams A, Manias E, Liew D, Gock H & GorelikВ A.
2012. Working with CALD groups: testing the
feasibility of an intervention to improve medication
self-management in people with kidney disease,
diabetes, and cardiovascular disease. Renal Society
of Australasia Journal. 8 (2); 62–69.
Wu BJ, Chen K, Barter PJ & Rye K-A. 2012. Niacin
Inhibits Vascular Inflammation via the Induction of
Heme Oxygenase-1. Circulation. 125 (1); 150–158.
Xu, Huntington, Harder, Nandurkar HH, Hibbs
&В Tarlinton . 2012. Phosphatidylinositol-3 kinase
activity in B Cells is negatively regulated by Lyn
tyrosine kinase. Immunology and Cell Biology.
90 (9); 903–911.
Yazdabadi A, Whiting, Rufaut NW & Sinclair RD.
2012. Miniaturized hairs maintain contact with
theВ arrector pili muscle in alopecia areata but
notВ inВ androgenetic alopecia: a model for reversible
miniaturization and potential for hair regrowth.
International Journal of Trichology. 4 (3); 154–157.
Yuen DA, Stead BE, Zhang Y, White KE, Kabir MG,
Thai K, Advani SL, Connelly KA, Takano T, Zhu L,
Cox AJ, Kelly DJ, Gibson IW, Takahashi T, Harris RC
& Advani A. 2012. eNOS Deficiency Predisposes
Podocytes to Injury in Diabetes. Journal of the
American Society of Nephrology. 23 (11); 1810–
1823.
Yu, Hanssen, Kalyanaraman, Chirindel, JenkinsВ A,
Nankervis, Torjesen, Scholz, Henriksen, Garg
& Lorentzen . 2012. Reduced soluble receptor
for advanced glycation end-products (sRAGE)
scavenger capacity precedes pre-eclampsia in
Type 1 Diabetes. BJOG. 119 (12); 1512–1529.
Zhang L, Yan F, Zhang S, Lei D, Charles MA,
Cavigiolio G, Oda M, Krauss RM, Weisgraber
KH, Rye K-A, Pownall HJ, Qiu X & Ren G. 2012.
Structural basis of transfer between lipoproteins
byВ cholesteryl ester transfer protein. Nature
Chemical Biology. 8 (4); 342–349.
st vincent’s research report 2012
185
University of Melbourne Department of Medicine
Zhang Y, Edgley AJ, Cox AJ, Powell, Wang,
KompaВ A, Stapleton DI, Zammit S, Williams SJ,
KellyВ DJ, Gilbert RE & Krum H. 2012. FT011,
aВ newВ anti-fibrotic drug, attenuates fibrosis
andВ chronic heart failure in experimental diabetic
cardiomyopathy. European Journal of Heart
Failure. 14 (5); 549–562.
Zhang Y, Morris KL, Sparrow SK, Dwyer KM,
EnjyojiВ K, Robson SC & Kishore BK. 2012.
DefectiveВ renal water handling in transgenic
miceВ over-expressing human CD39/NTPDase1.
American Journal of Physiology: Renal Physiology.
303 (3); F420–F430.
Zimmet H, Porapakkham P, Sata Y, Haas SJ,
ItescuВ S, Forbes A & Krum H. 2012. Shortand long-term outcomes of intracoronary and
endogenously mobilized bone marrow stem cells
inВ the treatment of ST-segment elevation myocardial
infarction: a meta-analysis of randomized control
trials. European Journal of Heart Failure. 14 (1);
91–105.
Zurbig, Jerums, Hovind, Macisaac RJ, Mischak,
Nielsen, Panagiotopoulos, Persson & Rossing
. 2012. Urinary Proteomics for Early Diagnosis
inВ Diabetic Nephropathy. Diabetes. 61 (12);
3304–3313.
Journal Articles Unrefereed
Criscitiello, Metzger-Fiho, Saini, De Castro, Diaz
&В La Gerche A. 2012. Targeted therapies in breast
cancer: are heart and vessels also being targeted?
Breast Cancer Research. 14 (3); 209.
Holmes J, Desmond PV & Thompson AJ. 2012.
Does IL28B genotyping still have a role in the era
ofВ direct-acting antiviral therapy for chronic hepatitis
C infection? Journal of Viral Hepatitis. 19 (10);
677–684.
Jayasekera, Desmond PV, Holmes, Kitson & Taylor.
2012. Cluster of 4 cases of esophageal squamous
cell cancer developing in adults with surgically
corrected esophageal atresia – time for screening to
start. Journal of Pediatric Surgery. 47 (4); 646–651.
Nikpour M, Harvey PJ, Ibanez D, Gladman DD &
Urowitz MB. 2012. High-sensitivity C-reactive protein
as a marker of cardiovascular risk in systemic lupus
erythematosus. Arthritis and Rheumatism. 64 (9);
3052–3053.
Thakkar, Stevens, Prior DL, Moore, Byron, Liew
&В Nikpour M. 2012. N-terminal pro-brain natriuretic
peptide in a novel screening algorithm for pulmonary
arterial hypertension in systemic sclerosis: a
case-control study. Arthritis Research & Therapy.
14В (3);В R143.
Thompson AJ & Mchutchison . 2012. Will IL28B
Polymorphism Remain Relevant in the Era of
Direct-Acting Antiviral Agents for Hepatitis C Virus?
Hepatology. 56 (1); 373–381.
Zalcberg JR & Desai J. 2012. Dose optimization
ofВ tyrosine kinase inhibitors to improve outcomes
inВ GIST. Asia Pacific Journal of Clinical Oncology.
8 (1); 43–52.
Journal Articles Unrefereed Letters or Notes
Hofman MSH. 2012. Special delivery:
gettingВ radiation to the target in diffuse large
B-cellВ lymphoma. Leukemia and Lymphoma.
53 (5); 751–753.
Martin TJ. 2012. Iain MacIntyre. 30 August 1924
— 18 September 2008. Biographical Memoirs of
Fellows of the Royal Society. 58; 179–201.(Not Final)
Nath AK, Timshina DK, Thappa DM & Sinclair R.
2012. Demodex in an aerobic environment on the
eyelashes. Australasian Journal of Dermatology.
53 (2); 159–160.
Papp KA, Reid C, Foley P, Sinclair R, SalingerВ DH,
Wil, Dong H, Krueger JG, Russell CB & Mar. 2012.
Anti-IL-17 Receptor Antibody AMG 827 Leads to
Rapid Clinical Response in Subjects with Moderate
to Severe Psoriasis: Results from a Phase I,
Randomized, Placebo-Controlled Trial. Journal of
Investigative Dermatology. 132 (10); 2466–2469.
Yip LW, Zaloumis S, Irwin D, Severi G, HopperВ JL,
Giles GG, Harrap S, Sinclair R & Ellis J. 2012.
Association analysis of oestrogen receptor beta
gene (ESR2) polymorphisms with female pattern
hairВ loss. British Journal of Dermatology. 166 (5);
1131–1134.
Zalcberg JR. 2012. Comparative effectiveness
research – a proposal for a new NHMRC funding
stream. Medical Journal of Australia. 196 (1); 22–23.
st vincent’s research report 2012
186
University of Melbourne Department of Medicine
Other Refereed Contribution
toВ RefereedВ Journals
Bursell SE, Brazionis L & Jenkins A. 2012.
Telemedicine and ocular health in diabetes
mellitus.В Clinical and Experimental Optometry.
95 (3); 311–327.
Campbell DJ. 2012. Vaccination Against High Blood
Pressure. Current Pharmaceutical Design. 18 (7);
1005–1010.
Chia J, Mcrae L, Cowan PJ & Dwyer KM. 2012.
The CD39-Adenosinergic Axis in the Pathogenesis
of Immune and Nonimmune Diabetes. Journal
of Biomedicine and Biotechnology. 2012 (2012);
320495.
Coventry BJ & Ashdown ML. 2012. Complete
clinical responses to cancer therapy caused
byВ multiple divergent approaches: a repeating
theme lost in translation. Cancer Management
and Research. 4 (1); 137–149.
De Cruz P, Kamm M, Prideaux I, Allen & Desmond
PV. 2012. Postoperative Recurrent Luminal Crohn’s
Disease: A systematic Review. Clinical Reviews
in Allergy & Immunology. 18 (4); 758–777.
Edgley AJ, Krum & Kelly DJ. 2012. Targeting
Fibrosis for the Treatment of Heart Failure:В A Role
for Transforming Growth Factor-ОІ. Cardiovascular
Therapeutics. 30 (1); e30–e40.
Flanagan D, Fisher T, Murray MJ, Visvanathan R,
Charlton K, Thesing C, Quigley G & Walther K. 2012.
Managing undernutrition in the elderly Prevention is
better than cure. Australian Family Physician. 41 (9);
695–699.
Fransen M, Karahalios A, Sharma N, English D,
GilesВ G & Sinclair RD. 2012. Non-melanoma skin
cancer in Australia. Medical Journal of Australia.
197 (10); 565–568.
Hawley SA, Fullerton MD, Ross FA, SchertzerВ JD,
Chevtzoff C, Wal, Peggie MW, Zibrova D,
GreenВ KA,В Mustard KJ, Kemp BE, Sakamoto
K, Steinberg G & Hardie DG. 2012. The Ancient
DrugВ Salicylate Directly Activates AMP-Activated
Protein Kinase. Science. 336 (6083); 918–922.
Heidbuchel, Prior DL & La Gerche A. 2012.
Ventricular arrhythmias associated with long-term
endurance sports: what is the evidence? British
Journal of Sports Medicine. 46 (Suppl.1); i44–i50.
Hicks RJ & Hofman MS. 2012. Is there still a role
forВ SPECT-CT in oncology in the PET-CT era?
Nature Reviews Clinical Oncology. 9; 712–720.
Hofman MS & Hicks RJ. 2012. Changing Paradigms
with Molecular Imaging of Neuroendocrine Tumors.
Discovery Medicine: discovery class of medicine,
research technology, and tools. 14 (74); 71–81.
Januszewski AS, Karschimkus C, Davis KE,
O’Neal DN, Ward GM & Jenkins A. 2012.
PlasmaВ 1,5 anhydroglucitol levels, a measure
ofВ short-term glycaemia: Assay assessment
andВ lower levels in diabetic vs. non-diabetic
subjects.В Diabetes Research and Clinical Practice.
95 (1); e17–e19.
Jelinek GA. 2012. The developing challenge of
clinical longevity. Emergency Medicine Australasia.
24 (2); 201–202.
Jolliffe & Sinclair RD. 2012. Excision biopsy in
aВ patient with suspected local anaesthetic allergy:
use of 0.9% saline with benzyl alcohol as local
anaesthesia. Clinical and Experimental Dermatology.
37 (8); 862–864.
Lekawanvijit, Kompa A, Wang, Kelly DJ & Krum H.
2012. Cardiorenal Syndrome: The Emerging Role of
Protein-Bound Uremic Toxins. Circulation Research.
111 (11); 1470–1483.
Maple LJ, Hughes JT, Lawton P, Jones G,
EllisВ AG, Drabsch K, Brown A, Cass A, Hoy
WE, Macisaac RJ, O’Dea K & Jerums G. 2012.
AccurateВ Assessment of Kidney Function in
Indigenous Australians: the Estimated GFR Study.
American Journal of Kidney Diseases. 60 (4);
680–682.
Mclachlan S-A, Clements A & Austoker J. 2012.
Patients’ experiences and reported barriers to
colonoscopy in the screening context-A systematic
review of the literature. Patient Education and
Counseling. 86 (2); 137–146.
Morrisroe K, Sim I, Mclachlan KA & Inder WJ.
2012.В Carcinoid crisis induced by repeated
abdominal examination. Internal Medicine Journal.
42 (3); 342–344.
st vincent’s research report 2012
187
University of Melbourne Department of Medicine
Ng SC, Tsoi KKF, Kamm MA, Xia B, Wu J,
ChanВ FKL, Sung JJY. 2012. Genetics of
inflammatoryВ bowel disease in Asia: Systematic
reviewВ and meta-analysis. Inflammatory Bowel
Diseases. 18 (6); 1164–1176.
Noll JE, Williams SA, Purton LE & Zannettino ACW.
2012. Tug of war in the haematopoietic stem cell
niche: do myeloma plasma cells compete for
theВ HSC niche? Blood Cancer Journal. 2; e91.
Oakhill JS, Scott JW & Kemp BE. 2012. AMPK
functions as an adenylate charge-regulated protein
kinase. Trends in Endocrinology and Metabolism.
23 (3); 125–132.
Peel T, Buising KL & Choong PFM. 2012.
DiagnosisВ and management of prosthetic joint
infection. Current Opinion in Infectious Diseases.
25 (6); 670–676.
Philip J, Lowe AJ, Gold M, Brand C, Miller B,
Douglass J & Sundararajan V. 2012. Palliative care
for patients with chronic obstructive pulmonary
disease: exploring the landscape. Internal Medicine
Journal. 42 (9); 1053–1057.
Prideaux L, De Cruz P, Ng SC, Kamm MA. 2012.
Serological antibodies in inflammatory bowel
disease: A systematic review. Inflammatory
Bowel Diseases. 18 (7); 1340–1355.
Ramot, Sinclair RD & Zlotogorski . 2012. Regrowth
ofВ black hair in two red-haired alopecia areata
patients. Australasian Journal of Dermatology.
53 (4); e91–e92.
Tang C, Godfrey T, Stawell R & Nikpour M. 2012.
Hydroxychloroquine in lupus: emerging evidence
supporting multiple beneficial effects. Internal
Medicine Journal. 42 (9); 968–978.(Not Final)
Vethakkan R, Walters-Bressan JM, Gooley JL,
Boston C, Kay TW, Goodman DJ, Jenkins A &
WardВ GM. 2012. Normalized NEFA Dynamics
DuringВ an OGTT After Islet Transplantation.
Transplantation. 94 (7); E49–E51.
Vu T, Varadarajan S, Seeman E, Jerums G &
Macisaac RJ. 2012. Hypocalcemia induced by
raloxifene. Current Drug Safety. 7 (2); 176–178.
Wall M, Rayeroux KC, Mackinnon RN, Zordan
A & Campbell LJ. 2012. ETV6 deletion is a
common additional abnormality in patients with
myelodysplastic syndromes or acute myeloid
leukemia and monosomy 7 (letter). Haematologica.
97 (12); 1933–1936.
Full Written Papers Refereed
Kompa A, Kelly DJ & Krum H. 2012. Cardiorenal
syndrome: Pathophysiology, preclinical models,
management and potential role of uraemic toxins.
In Liu, Lekawanvijit & Wang H(eds), Clinical and
Experimental Pharmacology and Physiology. 39
(8): 692–700. Australia: Blackwell Publishing Asia.
Lu J, Kazmierczak EA, Manton JH & Sinclair RD.
2012. Automatic scoring of erythema and scaling
severity in psoriasis diagnosis. Proceedings
ofВ theВ 25th Australasian Joint Conference
on Artificial Intelligence. 73–84. New York,
UnitedВ States: Springer.
Rye K-A & Barter PJ. 2012. Predictive value
ofВ different HDL particles for the protection
againstВ or risk of coronary heart disease. Biochimica
et Biophysica Acta: Molecular and Cell biology
of Lipids. 1821 (3); 473–480.
Sinclair R. 2012. Winding the clock back on
female androgenetic alopecia. British Journal
of Dermatology. 166 (6); 1157–1158.
Stagg J, Thompson LF & Dwyer KM. 2012.
Ectonucleotidases in Cancer and Inflammation.
Journal of Biomedicine and Biotechnology.
2012;В 951423.
Tam CS & Gandhi . 2012. Modifying the immune
system to treat chronic lymphocytic leukemia.
Leukemia and Lymphoma. 53 (2); 177–178.
st vincent’s research report 2012
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University of Melbourne
department of surgery
The mission of the Department of Surgery
is to promote and foster surgery within the
St Vincent’s Hospital campus and the University
of Melbourne. To achieve this, the Department
of Surgery focuses on four main areas namely,
Research and Research Training, Teaching and
Career Development, Clinical Leadership and
Strategic Health Services Policy and Practice.
ABOUT US
The University of Melbourne Department of Surgery
undertakes basic, translational, and clinical research
across a range of specialties. Basic and translational
research focuses on the areas of osteosarcoma
and breast cancer, while clinical cancer research is
conducted in the many surgical units affiliated with
the Department of Surgery, including orthopaedics,
vascular, ENT, thoracic, colorectal and upper GI,
urology, head and neck, breast and endocrine,
plastic and reconstructive, and neurosurgery. Clinical
cancer research is driven by our commitment
to multidisciplinary cancer care and is strongly
supported by St Vincent’s Hospital participation
andВ leadership in the various tumour streams.
Professor Peter Choong heads an internationally
recognized translational research program that
focuses on (1) improving health outcomes for
patients undergoing joint replacement surgery, (2)
the regulation of osteosarcoma growth, invasion
and metastasis and (3) developing novel ways
to reconstruct partial or complete limb loss from
tumour, trauma or degeneration.
Arthritis care: Our research explores factors that
affect health and economic outcomes and patient
satisfaction following arthritis surgery. These include
patient, procedural, prosthetic and perioperative
factors. A database of over 8,500 joint replacements
underpins our research and this information informs
our programs of research. Our research into arthritis
surgery is critical for ensuring the best outcomes
forВ patients and that policies and practice are
evidence-based.
Musculoskeletal tumours: Using advanced imaging
techniques, we are investigating the ways that bone
tumours grow and spread, and how they can be
treated with novel approaches. The mechanisms
we are studying include cell-cell and cell-matrix
interactions, the role of quantum dots in tracking
interactions, and the use of megavoltage radiotherapy
derived from the Australian Synchrotron.
Advanced limb reconstruction: Capitalising on
advances in polymer science, nanotechnology
and manufacturing, our research is studying how
specially fabricated materials can be used to replace
bone and soft tissues after tumour resection. These
new approaches are looking to develop functional
units of artificial muscles, structural devices from
additive manufacturing (3-D printing, selective laser
melting) and tissue using regenerative and cellular
engineering techniques.
In collaboration with St Vincent’s Hospital
Department of Orthopaedics and the Centre
for Population Health in St Vincent’s Hospital
Department of Medicine, the St Vincent’s Joint
Replacement Registry underpins research
into factors that influence outcomes after joint
replacement, including a better understanding of
the economics of joint replacement. In addition,
collaborations have been established with the
St Vincent’s Mental Health Unit/University of
Melbourne Department of Psychiatry to assess the
psychosocial aspects of joint replacement, surgery
and obesity.
Professor Erik Thompson heads an internationally
recognized research program into aspects of
breast cancer invasion and metastasis, with
particular focus on epithelial-mesenchymal plasticity
(EMP), mammographic density (MD), matrix
metalloproteinases (MMPs), and bone metastasis
(BM). Professor Michael Henderson works closely
with Professor Thompson on several of these areas
and also performs clinical research into the surgical
management of breast cancer.
Through the closely allied O’Brien Institute, extensive
research has been undertaken to develop innovative
microsurgical techniques in tissue transplantation
and to improve the outcome following tissue
transfers for elective and trauma surgery. Professor
Wayne Morrison and his teams are driving a
programme that studies the process of angiogenesis
and tissue regeneration utilising their murine
bioengineering chamber to better understand the
regulation of successful tissue engineering.
st vincent’s research report 2012
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University of Melbourne department of surgery
HIGHLIGHTS
Professor Peter Choong
Our research into arthritis has identified that obesity
and psychological distress are emerging as highly
important but modifiable risk factors for sub-optimal
outcome following total joint replacement. Our
research has led to 2 world first collaborative studies
commencing in 2012 that are assessing the potential
to improve outcomes in these groups.
• The Arthroplasty and Bariatric Surgery Study:
Knee replacement is a common surgical
procedure in Australia (46,000 per year). More
than 60% of this group are obese and this is
associated with higher early (clinical) and long term
(implant) survival complications. Laparoscopic
adjustable gastric banding (LAGB) is an effective
and safe means of achieving sustained weight
loss. This study compares the outcomes of total
knee replacement in groups of severely obese
patients who have and have not undergone preknee replacement LAGB.
• Mindfulness, cognitive processes and coping
in chronic illness: insights from a study of joint
replacement surgery: This study investigates
whether participation in a mental health
enhancement program (mindfulness) with will
improve the recovery of patients undergoing total
joint replacement. This will benefit patients by
promoting psychological well-being which has
direct effects on pain and physical function after
surgery.
• Our research into musculoskeletal tumours has
been selected as one of the key areas for research
at the Australian Synchrotron. This collaboration
will allow us to undertake research that utilises
the power of the synchrotron to provide highresolution images of tumours and the way in which
they may interact with bone. Specially focused
beams of radiation are also being used to test new
ways of treating bone tumours that may not be
able to be removed by surgery alone.
• Investigation of the tumour-to-bone interface in
osteosarcoma. Work performed on Imaging and
Medical Beamline: Project IM5234; Beam time
23-26 Nov 2012. Osteosarcomas are invasive
tumours that infiltrate and destroy bone causing
high morbidity for patients. A key aim of this
study has been to improve imaging of the tumour
and the tumour-to-bone interface. This beam
time on the IMBL has produced high resolution
3-dimensional images of primary tumour to clearly
depict how the tumour cells interact with the bone
and with excellent definition of the lytic effects on
bone. This information is being used for design
of a study in which microbeam radiation therapy
(MRT) will be tested at the Australian Synchrotron
for the treatment of aggressive sarcoma tumours.
• Quantum dots: Novel fluorescent probes shed
light on bone disease and tumour progression.
In this project, novel coupling chemistry is being
used to label a ligand, calcitonin that binds the
calcitonin receptor present on bone lytic cells
called osteoclasts. Calcitonin is a regulatory
hormone that mediates bone formation and
this capacity to label these highly active cells in
bone will provide information on the physiological
role of CT as well as enable the �tracking’ of
these important cells in our in vitro and in vivo
experiments when studying tumours of bone and
other bone diseases.
Our research into advanced limb reconstruction
has seen the development of a national
collaboration between St. Vincent’s Hospital,
University of Melbourne, University of Wollongong,
Royal Melbourne Institute of Technology and
the Queensland University of Technology. This
capitalises on specialised capabilities from the
fields of polymer research, advanced materials
manufacturing, tissue engineering and surgery.
Research projects include the regeneration of
cartilage using stem cell techniques on specially
designed structures, studying how nerves can be
stimulated to grow and attach to artificial surfaces,
the development of metallic structures from
advanced manufacturing techniques to fill bone
defects and the role of electrochemical polymers
as materials to mimic the action of muscles.
These studies form one of the many facets of
bioengineering research of the ACMD group.
• Regeneration of cartilage in chondral and
osteochondral defects. In this project we have
devised a novel approach for regeneration of
cartilage defects and osteochondral defects. Our
approach combines the use of chondrocyte stem/
progenitor cells in combination with a biosynthetic
or biological matrix.
• Investigation of surface nanostructured
titanium alloys for prosthetic devices. The
Department of Mechanical Engineering through
the School of Engineering at the University
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University of Melbourne department of surgery
of Melbourne manufacture different titanium
alloys with nanostructured surface properties.
Biocompatibility studies are being conducted
toВ determine appropriate substrates for growth
ofВ cells with the aim to improve biocompatibility
ofВ metals used for prosthetic devices.
• Optimizing neuromuscular junctions for direct
nerve to muscle neurotisation. The aim of this
project is to improve outcomes for patients
with neuromuscular dysfunction after injury or
surgery. Muscle reinnervation, called neurotisation,
is being studied using in vitro modelling in
neuronal cell-muscle cell co-cultures; the focus
is to improve neuromuscular junction formation
using pre-patterning of receptor expression and
bioengineering techniques.
• Studying the impact of poorly performed
community surgery on the outcomes of patients
with musculoskeletal tumours.
• Studying the development of cartilage tissue
fromВ stem cells.
• Studying the efficacy of conducting polymers
asВ artificial muscles.
• Studying the molecular factors that regulate
theВ development of neural synapses.
AWARDS
Dr Michelle Dowsey
National Health and Medical Research Council –
Early Career Australian Clinical Fellowship
• Electrochemical materials as muscle substitutes.
This project is studying the possibility of replacing
injured muscle with synthetic material that can
be actuated by electrical impulses to alter their
shape thereby producing contractions. This may
be useful for people who have suffered stroke,
partialВ muscle loss or sphincter disturbance.
Dr Michelle Dowsey
PROJECTS
Dr. Trisha Peel
• The Arthroplasty and Bariatric Surgery
(ABS) Study: a randomised controlled trial
ofВ laparoscopic adjustable gastric banding
priorВ toВ total knee arthroplasty (2012-2015)
National health and Medical Research Council
– Scholarship
• Mindfulness and coping in chronic illness:
insightsВ from a study of joint replacement surgery
(2012-2014)
Australian Rheumatology Association Victorian
Branch Inaugural Annual Scientific Meeting –
Best Abstract and Oral Presentation 2012 for
“Associations between pre-operative radiographic
changes and outcomes after total knee joint
replacement for osteoarthritis”
Dr. Ken Ye
National Health and Medical Research Council
– Scholarship
Dr. Bill Zhang
• Evaluating the impact of obesity on knee load
over time in those who have undergone optimal
surgical re-alignment after total knee replacement
(2012-2014)
National Health and Medical Research Council
– Scholarship
• Examining psychological state in patients
presenting for arthritis surgery (2012-2015)
High mammographic density (HMD) adjusted for age
and body mass index (BMI) is a strong and heritable
risk factor for breast cancer (BC). We extended our
�within breast’ comparison of HMD versus low MD
tissue in murine bioengineering chambers developed
at the O’Brien Institute, a world first in this topical
area. In a collaborative study we further showed
that solitary tumour cells (the presence of which
correlated with local recurrence in BC, were found
inВ HMD breast tissue,
• A pilot study investigating dietetic weight loss
interventions and 12-month functional outcomes
of patients undergoing knee or hip surgery
• A prospective, single-arm, uncontrolled, multicentre study to evaluate the safety and efficacy of
the DePuy AVN Cage prosthesis for the treatment
of avascular necrosis of the hip.
• Studying the differences in nuclear tracers
forВ targeting bone metastases.
Professor Erik Thompson
Matrix metalloproteinases (MMPs) have important
roles in the spread of cancer in the body, especially
to bone. We showed that the weakening of bone
that is typical of BC spread to bone and can be
st vincent’s research report 2012
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University of Melbourne department of surgery
abrogated by a small molecule that inhibits MMP13. Circulating tumour cells (CTC) are found in the
blood of cancer patients and their numbers and
characteristics give clues to disease progression
and spread. To understand the spread of BC in the
body and the role of EMP, which is a set of cellular
characteristics that influence cancer spread, we
have been developing a method to study CTC
fromВ BC patients, another first in Australia.
Dr Edmund EK, Surgical Lead- Senior Lecturer0.1
EFT
QUALITY
Mr Patrick Hayes, Lecturer, 0.2 EFT
Professor Peter Choong
Dr Bridget Langley, Surgical Lead- Senior Lecturer,
0.3 EFT
• As a result of our current research initiatives into
obesity we have established a dietetic service in
the Orthopaedic pre-admission clinic and have
commenced evaluating the impact of this service
on patient outcomes in those undergoing knee
orВ hip surgery
• Our research into infection after total joint
replacement has informed the development for
guidelines to treat acute prosthetic joint infections.
Professor Erik Thompson
We have undertaken the EMPathy �clinical trial’
in consenting breast cancer patients undergoing
surgery, so as to monitor their CTCs through
therapy. Through this trial we are enlightening both
clinicians and patients alike to the potential benefits
of examining CTC.
STAFF
Prof. Peter F M Choong, Head of Department and
Professor, 1.0 EFT
Prof Erik Thompson, Principal Research Fellow, 0.5
EFT
Prof Wayne Morrison, (Honorary)
Prof Michael Henderson (Honorary)
Ms Toni Ardino, Personal Assistant,1 EFT
Ms Cheryl Augustine, Research Assistant, 0.5 EFT
Dr Christine Chaffer, Research Fellow, 0.1 EFT
Mr Philip Davis, Surgical Lead- Senior Lecturer, 0.1
EFT
Miss Irene Esquivel, Information Technology
Manager, 0.1 EFT
Dr Scott Ferris, Surgical Lead- Senior Lecturer0.1
EFT
Mr Adrian Fox, Surgical Lead- Senior Lecturer, 0.1
EFT
Dr Raoul Mayer, Surgical Lead- Senior Lecturer, 0.1
EFT
Mr Alam Naveed, Surgical Lead- Senior Lecturer, 0.1
EFT
Dr Elizabeth Nelson, Clinical Research Associate, 1
EFT
Dr Katherine Nesbitt, Academic Centre Manager, 0.2
EFT
Dr Linh Nguyen, Research Assistant, 0.4 EFT
Dr Catherine Poliness, Surgical Lead- Senior
Lecturer, 0.1 EFT
Mr Christopher Pullen, Surgical Lead- Senior
Lecturer, 0.1 EFT
Mr Dhanabalan Thiruchelvam, Surgical Lead- Senior
Lecturer, 0.1 EFT
Mr Yi Wang, Surgical Lead- Senior Lecturer, 0.2 EFT
Dr Angela Webb, Surgical Lead- Senior Lecturer, 0.1
EFT
Dr Audi Widjaja, Surgical Lead- Senior Lecturer, 0.1
EFT
Honorary Staff
Dr Keren Abberton, Senior Fellow
Dr Nuzhat Ahmed, Senior Fellow
Mr Anmar Al-Shawi, Fellow
A/Prof David Allen, Principal Fellow
Mr Ravi Asopa, Fellow
Dr Benjamin Dixon, Surgical Lead- Senior Lecturer,
0.2 EFT
Mr Simon Banting, Fellow
Dr Michelle Dowsey, Head of Arthritis ResearchAustralian Early Career Clinical Fellow, 0.8 EFT
Mr Timothy Bennett, Senior Fellow
A/Prof Felix Behan, Principal Fellow
Prof Richard Bennett, Professor Emeritus
Mr Anthony Berger, Senior Fellow
st vincent’s research report 2012
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University of Melbourne department of surgery
Dr Susan Bortolotto, Fellow
A/Prof Damian Myers, Principal Fellow
Dr Anita Clarke, Fellow
Dr Andrew Newcomb, Clinical Senior Fellow
Dr Jeremy Crook, Principal Fellow
Mr Ian Nixon, Senior Fellow
Dr Michael Denton, Clinical Associate Professor
Mr Brendan O’Brien, Fellow
Dr Claudia Di Bella, Fellow
Dr Trisha Peel, Principal Fellow
Dr Rodney Dilley, Fellow
Dr Wayne Phillips, Principal Fellow
Dr George Dimitroulis, Fellow
Mr John Renney, Senior Fellow
Mr Anthony Dunin, Fellow
Dr Bernhard Riedel, Senior Fellow
Dr Cuong Duong, Senior Fellow
Dr John Rophael, Fellow
Prof Gregory Dusting, Professorial Fellow
A/Prof David Scott, Principal Fellow
Dr Michael Findlay, Senior Fellow
Dr Ramin Shayan, Fellow
Mr Roy Fink, Principal Fellow
A/Prof Brendan Silbert, Principal Fellow
Dr Aidan Fitzgerald, Senior Fellow
Mr John Spillane, Senior Fellow
Ms Yona Goldshmit, Fellow
Dr Caroline Taylor, Fellow
A/Prof Miron Goldwasser, Clinical Associate
Professor
Dr Catherine Temelcos, Senior Fellow
Dr John Gurry, Principal Fellow
Mr Dominic Vellar, Principal Fellow
Prof Michael Henderson, Professorial Fellow
Dr Mark Waltham, Senior Fellow
Prof Alexander Heriot Professorial Fellow
Dr Alan Woods, Fellow
Dr Kalindi Hettiarachchi, Fellow
Mr Rodney Woods, Senior Fellow
Mr Damian Ireland, Senior Fellow
Mr Gavin Wright, Clinical Associate Professor
Mr James Keck, Fellow
Dr Michael Yii, Fellow
Mr John Kennedy, Clinical Associate Professor
Dr Nao Kobayashi, Clinical Fellow
Dr Shiang Lim, Fellow
Dr Zerina Lokmic, Fellow
A/Prof Bruce Love, Clinical Associate Professor
Mr Mark Lovelock, Fellow
Mr Andrew Lynch, Clinical Senior Fellow
Dr Bernard Lyons, Clinical Associate Professor
Dr James Thomas, Fellow
Students
Richard Chiriano, Honours Student
Tania Zheng, Honours Student
Grace Chew, Doctor of Medical Science Student
Virginia E Cotta, Doctor of Medical Science Student
Cameron Keating, Doctor of Medical Science
Student
Mr John MacKay, Principal Fellow
Andrew Newcomb, Doctor of Medical Science
Student
Dr David Mccombe, Clinical Senior Fellow
Paul Conaglen, Master of Surgery Student
Mr Chris McCormack, Clinical Associate Professor
Eva Koo, Master of Surgery Student
Dr Geraldine Mitchell, Senior Fellow
Sameer Memon, Master of Surgery Student
Prof Wayne Morrison, Professorial Fellow
John Swan, Master of Surgery Student
Dr Andrew Muir, Senior Fellow
Beryl Tan, Master of Surgery Student
Mr Michael Murphy, Principal Fellow
Livia Williams, Master of Surgery Student
Mr Declan Murphy, Clinical Associate Professor
Hima Abeysinghe, PhD Student
st vincent’s research report 2012
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University of Melbourne department of surgery
Khalid Abubaker, PhD Student
SERVICE TO THE WIDER COMMUNITY
Sina Babazadeh, PhD Student
Prof Peter F M Choong
Matthew Broadhead, PhD Student
• Professor Surgery, University of Melbourne
Jonathan Clark, PhD Student
• Chair, Sarcoma service,
PeterВ MacCallumВ CancerВ Centre
Raminder Dhillon, PhD Student
Aaron Dingle, PhD Student
Benjamin Dixon, PhD Student
Lisbeth Evered, PhD Student
Raed Felimban, PhD Student
Christopher Hart, PhD Student
Shze Yung Koh, PhD Student
Ardian Latifi, PhD Student
Trisha Peel, PhD Student
Walter Pfister, PhD Student
Charles Pilgrim, PhD Student
Cletus Pinto, PhD Student
Kieran Rowe, PhD Student
Eliza Soo, PhD Student
Anthony Tachtsidis, PhD Student
Melissa Tang, PhD Student
Richard Tee, PhD Student
Jenny Than, PhD Student
Henry To, PhD Student
Zoe Wainer, PhD Student
Edwin Widodo, PhD Student
Michael Williams, PhD Student
Gavin Wright, PhD Student
Ken Ye, PhD Student
Bill Zhang, PhD Student
Theses passed in 2012
Kristian Bullus, PhD, University of Melbourne
Devika N PA Gunasinghe, PhD, University
ofВ Melbourne
Charles Pilgrim, PhD, University of Melbourne
• Head, Department of Surgery,
University of Melbourne, St. Vincent’s Hospital
• Chair, Academic Centre, University of Melbourne,
St. Vincent’s Hospital
• Assistant Dean, Faculty of Medicine,
DentistryВ andВ Health Sciences
• Director of Education and Training,
AustralianВ Orthopaedic Association
• Chair, Board of Orthopaedic Surgery,
RoyalВ Australasian College of Surgeons
• Chair, Victorian Orthopaedic Research Trust
Scientific Advisory Committee
• Member, Board of Australian Orthopaedic
Association
• Member, Orthopaedic Workforce Committee,
Australian Orthopaedic Association
• Member, Medical Schedule Advisory Committee,
Department of Health & Ageing
• Section (Orthopaedics) Editor,
ANZВ JournalВ ofВ Surgery
• Member, Editorial Board, Journal of Bone & Joint
Surgery (British)
• Secretary, International Society of Limb
SalvageВ Surgery
• Secretary, Asio-Pacific Musculoskeletal
TumourВ Surgery
• Member, Board of Australian Sarcoma
StudyВ Group
• Member, Council of Genazzano FCJ College
• Member, Rotary Club of Melbourne
Prof Erik Thompson
• Member, Committee, Australasian Microarray
andВ Associated Technologies Association
• President, Metastasis Research Society
• Vice President, The EMT International Association
• Member, Tumour Microenvironment Steering
Committee, American Association for Cancer
Research
st vincent’s research report 2012
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University of Melbourne department of surgery
• Speaker, King & Wood Malleson’s Pink Ribbon
Breakfast, Melbourne; 19 October
• Speaker, Mother’s Day Classic, Melbourne;
13В May
• 2010 Co-founder, St. Vincent’s Campus
Bioinformatics Working Group
• Member, St Vincent’s Campus Research
Technology Committee
• Member, St. Vincent’s Hospital BioResource
Centre Users Committee
• Member, Victorian Functional Genomics
CentreВ Steering Committee, Peter MacCallum
Cancer Centre
• Member, St. Vincent’s Hospital Research
TrainingВ Committee
Choong, P (CIA), Brown W, Liew D, Dowsey M
The Arthroplasty and Bariatric Surgery Study:
A randomised controlled trial of laparoscopic
adjustable gastric banding prior to total knee
arthroplasty, NHMRC
$643,670 for 2012-2015 ($160,917 for 2012)
Choong, P
Alzheimer’s disease processes, NHMRC
$157,187 for 2012
Choong P, Myers D, Wallace G, Pandy M, Zhang B
Building artificial muscle for limb reconstruction after
tumour surgery, Australian Orthopaedic Association
$50,000 for 2012
Choong P, May D
• Bernard O’Brien Institute of Microsurgery Scientific
Oversight Committee
Investigating outcomes and patient self assessment
of health status in the surgical management of
musculoskeletal tumours, Research Endowment
Fund
$15,000 for 2012
• Working group (Audit 1) for Cancer Australia’s
National Audits of Cancer Research
Simmance N, Gandler N, Dowsey M, Choong P
• Member, Tissue Resource Management
Committee, Peter MacCallum Cancer Centre
• Peter MacCallum Cancer Centre Research
Division Promotion Panel
• Convenor of 14th Biennial MRS Conference, Sept.
2–5, 2012. Brisbane, QLD
GRANTS AND/OR RESEARCH INCOME
Choong, PFM
The health work force Australia, HWA Government
$1,200,000 for 2011-2013 ($400,000 in 2012)
Choong P
A prospective, single-arm, uncontrolled, multi-centre
study to evaluate the safety and efficacy of the
DePuy AVN Cage prosthesis for the treatment of
avascular necrosis of the hip, Johnson & Johnson
Inc
$143,120 for 2011-13 ($47,706 in 2012)
Dowsey M
Examining psychological state in patients presenting
for arthritis surgery, NHMRC
$294,892 for 2012-15 ($73,723 for 2012)
A pilot study investigating dietetic weight loss
interventions and 12-month functional outcomes of
patients undergoing knee or hip surgery, Research
Endowment Fund
$22,907 for 2012
Choong P (CIA), Castle D, Salzberg M, Dowsey
M, Knowles S, Monshat K
Mindfulness and coping in chronic illness: insights
from a study of joint replacement surgery, Australian
Research Council Discovery grant
$270,445 for 2012-14 ($90,148 in 2012)
Choong P (CIA), Bennell K, Wrigley T, Hinman R,
Dowsey M
Evaluating the impact of obesity on knee load over
time in those who have undergone optimal surgical
re-alignment after total knee replacement, Australian
Research Council Linkage grant
$706,196 for 2012 -2014 ($235,398 in 2012)
Tang M
Studies of psychological distress and outcome after
tumour surgery, Australian Postgraduate Award
Scholarship
$23,728 for 2012
st vincent’s research report 2012
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University of Melbourne department of surgery
Thompson E, Moller A, Dobrovic K, TraianedesВ K,
van Denderen B
Autologous reconstitution of bone marrow
micrometastatic miliew for propagation and analysis
of disseminated tumour cells in breast cancer,
National Breast Cancer Foundation project grant
$200,000 for 2012-2013 ($100,000 in 2012)
Thompson E, van Denderen B, Dobrovic A,
Wong N
Transcriptional and epigenetic regulation of
epithelial mesenchymal plasticity in breast cancer
dissemination, NHMRC
$639,685 for 2012-2014 ($214,995 in 2012)
Southey M, Thompson E, Haviv I, Hopper J,
Campbell I, Cawson J, Hill P, Stone J, Giles G,
Baglietto L, Nickson C, Lindeman G, Clybe C,
Morrison W, Apicella C
Molecular Determinants of mammographic density,
Victorian Breast Cancer Research Consortium
$1,297,125 for 2009-2012 ($45,000 in 2012)
Mitchell G, Penington A
Causes of human lymphatic and vascular
malformations, NHMRC
2009-2012
COLLABORATIONS IN RESEARCH
Monteith G, Roberts-Thomson S, Thompson E
International
Calcium signalling and epithelial-mesenchymal
transition: A new approach to identifying
pharmacological targets for metastasis, NHMRC
$543,675 for 2012-2014
• Professor Stefan Lohmander, Department
ofВ Orthopaedics, University of Lund, Sweden
Thompson E, Goodall G, Saunders C, Anderson
R, Yap A, Street I, Dobrovic A, Dowling A
• Université Joseph Fourier, Centre de Recherche
Inserm and ESRF, France
Targeting breast cancer recurrence through epithelial
mesenchymal plasticity, National Breast Cancer
Foundation
$5,150,286 for 2011-2016 ($1,134,340 in 2012)
• CHU Bicêtre, UNCE, Dept of Neurophysiology
andВ Epilepsy, Paris, France
Thompson E, Fabra Fres A, Goodall G,
Henderson M, Hill P
• Chris Overall UBC, Canada MMP13;
AIВ onВ NHMRC#502622
Novel microRNA regulators in the breast cancer
EMT, National Breast Cancer Foundation
$599,151 for 2010-2013 ($199,717 in 2012)
• Zena Werb UCSF MMP13-deficient mice
Thompson E, Haviv I, Waltham M
A functional genomic screen for tumorigenicity
telative to epithelial-mesenchymal transition, breast
cancer stem cell biology and therapeutic efficacy,
IDEA grant
US$374,765 for 2009-2012 ($124,922 in 2012)
• Professor Paul Dieppe, St. Peter’s College, Oxford
University, United Kingdom
• Angels Fabra-Fres IDIBELL, Spain – CI Cancer
Aust #628720
• Izhak Haviv Bar Ilan University, Israel
• University of Lund, Sweden
• National Institutes of Health, Maryland, USA
• National Heart Centre, Singapore
• Department of Pharmacology, Kyoto University,
Japan
• Shandong University, China
Waring P, Bowtell D, Desai J, Fox S, Gibbs P,
Landgren A, McArthur G, Rudzki Z, Solomon
B, Southey M (Thompson, EW, Associate
Investigator)
• ISIS Pharmaceuticals, Carlsbad, USA
Centre for translational pathology research and
training, NHMRC
$2,498,410 for 2012-2016
• Department of Cancer Cell Research, Institute of
Medical Science, University of Tokyo, Japan
• Karmanos Cancer Center, Detroit, USA
• Kanazawa Medical School, Japan
• Department of Anatomy, University of California,
San Francisco, USA
• Oxford University, United Kingdom
st vincent’s research report 2012
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University of Melbourne department of surgery
National
• Don Newgreen MCRI
• Professor David Castle, Department of Psychiatry,
University of Melbourne, St Vincent’s Hospital
• Leigh Ackland Deakin Univ
• Professor Peter Brooks, Australian Health
Workforce Institute, University of Melbourne
• Alex Dobrovic PMCC
• Professor Kim Bennell, Department of
Physiotherapy, University of Melbourne
• Greg Goodall IMVS Adelaide
• Robin Anderson PMCC
• Keith Stanley Ausdiagnostics
• Professor Danny Liew, Department of Medicine,
University of Melbourne, Royal Melbourne Hospital
• Lilian Soon U Syd
• Professor Jane Gunn, Department of General
Practice, University of Melbourne
• Jenny Cawson BreastScreen Victoria
• A/Prof Wendy Brown, Centre for Obesity Research
and Education, Monash University
• Dr Simon Knowles, Faculty of Life and Social
Sciences, Swinburne University
• Professor Marcus Pandy, Department of
Mechanical Engineering, University of Melbourne
• Ms Natalie Simmance, Aged Care & Allied Health
Nutrition, St. Vincent’s Hospital
• Professor Gordon Wallace, Intelligent Polymer
Research Institute, University of Wollongong
• Professor Marcus Pandy, Professor Kenong
Xia, Assoc. Prof. Vincent Lee, Department of
bioengineering and mechanical engineering,
University of Wollongong
• Professor Milan Brandt, School of Aerospace,
Mechanical and Manufacturing Engineering,
RMITВ University
• Professor Dietmar Hutmacher, Science and
Engineering Faculty, Queensland University
ofВ Technology
• Professor Paul Mulvaney, Bio21, School of
Chemistry, University of Melbourne, Parkville,
Victoria
• Alpha Yap IMB, Univ QLD
• Prof. John Hopper Center for MEGA,
• Univ Melb Prof. Melissa Southey
UnivВ MelbВ Pathology
• Intelligent Polymer Research Institute, University
of Wollongong Heart Research Institute, Sydney,
Australia
• Howard Florey Institute, Melbourne, Australia
• Department of Pharmacology, Monash University,
Melbourne, Australia
• Peter MacCallum Cancer Centre, Melbourne,
Australia
• Victor Chang Cardiac Institute, Sydney, Australia
• Deakin University, Melbourne, Australia
• Department of Obstetrics and Gynaecology,
University of Melbourne, Melbourne, Australia
• St Vincent’s Hospital, Melbourne, Australia
• Centre for MEGA Epidemiology, University
ofВ Melbourne, Melbourne, Australia
• Murdoch Children’s Research Institute,
Melbourne,В Australia
• Department of Biochemistry, Monash University,
Melbourne, Australia
• Professor Rodney Hicks, Peter MacCallum Cancer
Centre, Melbourne
• Australian Key Centre for Microscopy and
Microanalysis, NANO-MNRF, Sydney, Australia
• Professor Daniel Hausermann, Australian
Synchrotron, Clayton Victoria
• Department of Pathology, University of Melbourne,
Melbourne, Australia
• Professor Andrew Stevenson, X-Ray Physics
and Instrumentation Laboratory, CSIRO,
Clayton,В Victoria
• Ausdiagnostics, Melbourne, Australia
• Elizabeth Williams MIMR
• St Vincent’s Institute, Melbourne, Australia
• Monash Institute for Medical Research,
Melbourne, Australia
• Nuzhat Ahmed Ob&Gyn Univ Melb
• Prue Hill Pathology, SVH
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University of Melbourne department of surgery
PUBLICATIONS
Book chapters
Dowsey M, Peel T, Choong P. Infection in primary hip
and knee arthroplasty. In Infection in Primary Hip and
Knee Arthoplasty, Recent Advances in Arthroplasty,
Samo K. Fokter (ED.), ISBN:978-953-307-990-5,
InTech
Journal articles
Babazadeh S, Dowsey MM, Stone JD, Choong PF.
The accuracy of retrospectively measured range of
motion in knee arthroplasty. Acta Orthop Belg. 2012
Dec;78(6):751-6. PubMed PMID: 23409571.
Choong P. Soft tissue sarcoma: new paradigms
in care. Sarcoma. 2012;2012:439208. doi:
10.1155/2012/439208. Epub 2012 Dec 31.
PubMed PMID: 23346011; PubMed Central PMCID:
PMC3549354.
Shkolnikova J, Flynn J, Choong P. Burden of
bisphosphonate-associated femoral fractures.
ANZ J Surg. 2013 Mar;83(3):175-81. doi: 10.1111/
ans.12018. Epub 2012 Dec 6. PubMed PMID:
23216704.
Peel TN, Buising KL, Dowsey MM, Aboltins CA,
Daffy JR, Stanley PA, Choong PF. Outcome of
debridement and retention in prosthetic joint
infections by methicillin-resistant staphylococci,
with special reference to rifampin and fusidic acid
combination therapy. Antimicrob Agents Chemother.
2013 Jan;57(1):350-5. doi: 10.1128/AAC.0206112. Epub 2012 Oct 31. PubMed PMID: 23114758;
PubMed Central PMCID: PMC3535910.
Babazadeh S, Dowsey MM, Stoney JD, Choong PF.
The effect of tibio-femoral over-distraction in primary
knee arthroplasty. Knee Surg Sports Traumatol
Arthrosc. 2012 Oct 21. [Epub ahead of print]
PubMed PMID: 23085821.
Peel TN, Cheng AC, Choong PF, Buising KL.
EarlyВ onset prosthetic hip and knee joint infection:
treatment and outcomes in Victoria, Australia. J
Hosp Infect. 2012 Dec;82(4):248-53. doi: 10.1016/j.
jhin.2012.09.005. Epub 2012 Oct 22. PubMed
PMID: 23084482.
Grinsell D, Di Bella C, Choong PF. Functional
reconstruction of sarcoma defects utilising
innervated free flaps. Sarcoma. 2012;2012:315190.
doi: 10.1155/2012/315190. Epub 2012 Aug 28.
PubMed PMID: 22969309; PubMed Central PMCID:
PMC3434415.
Tang MH, Pan DJ, Castle DJ, Choong PF. A
systematic review of the recent quality of life studies
in adult extremity sarcoma survivors. Sarcoma.
2012;2012:171342. doi: 10.1155/2012/171342.
Epub 2012 Aug 23. PubMed PMID: 22966215;
PubMed Central PMCID: PMC3432553.
Peel TN, Buising KL, Choong PF. Diagnosis and
management of prosthetic joint infection. Curr Opin
Infect Dis. 2012 Dec;25(6):670-6. doi: 10.1097/
QCO.0b013e32835915db. PubMed PMID:
22964949.
Alford S, Choong P, Chander S, Henderson M,
Powell G, Ngan S. Outcomes of preoperative
radiotherapy and resection of retroperitoneal
sarcoma. ANZ J Surg. 2012 Sep 3. doi:
10.1111/j.1445-2197.2012.06211.x. [Epub ahead
ofВ print] PubMed PMID: 22943678.
Babazadeh S, Dowsey MM, Bingham RJ, Ek ET,
Stoney JD, Choong PF. The long leg radiograph
is a reliable method of assessing alignment when
compared to computer-assisted navigation and
computer tomography. Knee. 2012 Aug 11.
[EpubВ ahead of print] PubMed PMID: 22892197.
Huang NF, Dowsey MM, Ee E, Stoney JD,
Babazadeh S, Choong PF. Coronal alignment
correlates with outcome after total knee arthroplasty:
five-year follow-up of a randomized controlled
trial. J Arthroplasty. 2012 Oct;27(9):1737-41. doi:
10.1016/j.arth.2012.03.058. Epub 2012 Aug 3.
PubMed PMID: 22868073.
Dowsey MM, Nikpour M, Dieppe P, Choong PF.
Associations between pre-operative radiographic
changes and outcomes after total knee joint
replacement for osteoarthritis. Osteoarthritis
Cartilage. 2012 Oct;20(10):1095-102. doi:
10.1016/j.joca.2012.05.015. Epub 2012 Jul 16.
PubMed PMID: 22800770.
Qi SD, Smith PD, Choong PF. Nuclear
reprogramming and induced pluripotent stem cells:
a review for surgeons. ANZ J Surg. 2012 Oct 4. doi:
10.1111/j.1445-2197.2012.06282.x. [Epub ahead
ofВ print] PubMed PMID: 23035845.
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University of Melbourne department of surgery
Choong P, Brooks P. Achievements during the Bone
and Joint Decade 2000-2010. Best Pract Res Clin
Rheumatol. 2012 Apr;26(2):173-81. doi: 10.1016/j.
berh.2012.03.004. PubMed PMID: 22794093.
Broadhead ML, Choong PF, Dass CR. Efficacy
of continuously administered PEDF-derived
synthetic peptides against osteosarcoma
growth and metastasis. J Biomed Biotechnol.
2012;2012:230298. doi: 10.1155/2012/230298.
Epub 2012 May 30. PubMed PMID: 22701300;
PubMed Central PMCID: PMC3369529.
Choong PF. Comminuted radial head
fractures: picking up the pieces. ANZ J Surg.
2012 Jun;82(6):385-6. doi: 10.1111/j.14452197.2012.06100.x. PubMed PMID: 22672393.
Choong PF. Tourniquet use in knee replacement
surgery: what is the evidence? ANZ J Surg.
2012 Jun;82(6):384-5. doi: 10.1111/j.14452197.2012.06099.x. PubMed PMID: 22672392.
Crowley C, Dowsey MM, Quinn C, Barrington
M, Choong PF. Impact of regional and local
anaesthetics on length of stay in knee arthroplasty.
ANZ J Surg. 2012 Apr;82(4):207-14. doi:
10.1111/j.1445-2197.2011.05991.x. Epub 2012
Feb 3. Review. PubMed PMID: 22510175.
Dowsey MM, Dieppe P, Lohmander S, Castle D,
Liew D, Choong PF. The association between
radiographic severity and pre-operative function in
patients undergoing primary knee replacement for
osteoarthritis. Knee. 2012 Dec;19(6):860-5. doi:
10.1016/j.knee.2012.02.007. Epub 2012 Mar 23.
PubMed PMID: 22445613.
Peel TN, Cheng AC, Buising KL, Choong PF.
Microbiological aetiology, epidemiology, and clinical
profile of prosthetic joint infections: are current
antibiotic prophylaxis guidelines effective? Antimicrob
Agents Chemother. 2012 May;56(5):2386-91.
doi: 10.1128/AAC.06246-11. Epub 2012 Feb 6.
PubMed PMID: 22314530; PubMed Central PMCID:
PMC3346661.
Peel TN, Dowsey MM, Buising KL, Liew D, Choong
PF. Cost analysis of debridement and retention
for management of prosthetic joint infection.
Clin Microbiol Infect. 2013 Feb;19(2):181-6. doi:
10.1111/j.1469-0691.2011.03758.x. Epub 2012 Jan
20. PubMed PMID: 22264335.
Alford S, Choong P, Chander S, Henderson M, Chu
J, Powell G, Williams S, Ngan S. Value of PET scan
in patients with retroperitoneal sarcoma treated with
preoperative radiotherapy. Eur J Surg Oncol. 2012
Feb;38(2):176-80. doi: 10.1016/j.ejso.2011.11.001.
Epub 2011 Dec 9. PubMed PMID: 22154883.
Shah M, Huang D, Blick T, Connor A, Reiter L,
Hardink J, Lynch C, Waltham M, Thompson E.
An MMP13-Selective inhibitor delays primary
tumour growth and the onset of tumour-associated
osteolytic lesions in experimental models of breast
cancer. 2012 Jan.7(1):1-12.
Saunders, N.A., Simpson, F., THOMPSON, E.W.,
Hill, M.M., Endo-Munoz, L., Leggatt, G., Minchin,
R.F., Guminski, A. Role of intratumoral heterogeneity
in cancer drug resistance: molecular and clinical
perspective. EMBO Mol Med 4:675-684 (2012) doi:
10.1002/emmm.201101131. Epub 2012 Jun 25
Gunasinghe NPAD, Wells A, THOMPSON EW, Hugo
HJ. Mesenchymal-epithelial transition (MET) as a
mechanism for metastatic colonisation in breast
cancer. Cancer Met. Rev. 31:469-78 (2012) doi:
10.1007/s10555-012-9377-5
Hugo H, Lebret S, Tomaskovic-Crook E, Ahmed N,
Blick T, Newgreen D, Thompson E. Contribution of
fibroblast and mast cell (afferent) and tumor (efferent)
IL6 effects within the tumour microenvironment.
Cancer Microenvironment. 2012 Feb; 5(1):83-93.
Chew G, Huang D, Lin S, Hud C, Blick T, Henderson
M, Hill P, Cawson J, Morrison W, Campbell I, Hopper
J, Southey M, Haviv I, Thompson E. High and
low mammographic density human breast tissues
maintain histological differential in murine tissue
engineering chambers. Breast Cancer Research
andВ Treatment. 2012 Aug;135(1):177-187.
Raviraj V, Zhang H, Chien H, Cole L, Thompson
E, Soon L. Dormant but migratory tumour cells in
desmoplastic stroma of invasive ductal carcinomas.
Clinical and Experimental Metastasis. 2012
Mar.29(3):273-292
Srisuwan T, Tikorn D, Al-Benna S, Vashi A,
Penington A, Messer H, Abberton K, Thompson
E. Survival of rat functional dental pulp ells
inВ vascularized tissue engineering chambers.
TissueВ and Cell. 2012 Apr;44(2): 111-121
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University of Melbourne department of surgery
Tilkorn D, Davies E, Keramidaris E, Dingle A,
Gerrand Y, Taylor C, Han X, Palmer J, Penington
A, Mitchell C, Morrison W, Dusting G, Mitchell
G. The in vitro preconditioning of myoblasts to
enhance subsequent survival in an in vivo tissue
engineering chamber model. Biomaterials. 2012
May; 33(15):3868-3879
Haviv I, THOMPSON EW. Soiling the seed:
Microenvironment and epithelial mesenchymal
plasticity. Cancer Microenvironment 5(1): 1-3 (2012)
DOI 10.1007/s12307-012-0104-0
Bonnomet A, Syne L, Brysse A, Feyereisen E,
THOMPSON EW, NoГ«l A, Foidart J-M, Birembaut
P, Polette M, Gilles C. A dynamic in vivo model of
epithelial-to-mesenchymal transitions in circulating
tumor cells and metastases of breast cancer.
Oncogene 2012 31:3741-53
Raviraj V, Fok S, Zhao J, Chien H-Y, Lyons JG,
THOMPSON EW, Soon L. Regulation of ROCK1
via Notch1 during breast cancer cell migration
intoВ dense matrices. BMC Cell Biol 2012 13:12.
Conference publications
Annual Scientific Meeting of the AmericanCollege-of-Rheumatology (ACR) and Associationof-Rheumatology-Health-Professionals (ARHP)
Location: Washington, DC Date: NOV 09-14,2012
Le Marshall K, Yee B, Dieppe P, Leung A, Page C,
Choong P, Dowsey M, Lim K. Differences Between
Patients with Hip and Knee Osteoarthritis. Arthritis
and Rheumatism. 2012 Oct, 64(10);S117
Speaking engagements
Choong PF. Evidence for surgery in pelvic Ewing’s
– How robust is it. 85th Annual Scientific Meeting
of the Japanese Orthopaedic Association, Kyoto,
Japan, 15-17th May, 2012
Choong PF. Surgery for Ewing’s of the Pelvis – What
is the evidence? 1st Oriental Orthopaedic Congress,
Shanghai, China July 27-29, 2012
Choong PF. Margins for soft tissue sarcoma –
How close can you go? 1st Oriental Orthopaedic
Congress, Shanghai, China July 27-29, 2012
Choong PF. Osteoarthritis – The challenge of
surgical management. Bill Wheeler Symposium,
Intelligent Polymer Research Institute, University
ofВ Wollongong, August 6, 2012
Choong PF. Complications and its prevention in
metastatic surgery. 9th Asio-Pacific Musculoskeletal
Tumour Society Meeting, Kuala Lumpur, Malaysia,
September 8, 2012
Choong PF. Resection and reconstruction for
giant cell tumour – the debate. 9th Asio-Pacific
Musculoskeletal Tumour Society Meeting, Kuala
Lumpur, Malaysia, September 8, 2012
Choong PF. The challenges of academic surgery
in the new millennium. Prince Charles Hospital
Research Week. Brisbane, October 15-16, 2012
Choong PF, Peel T. Buising K, Cheng A. Outcome
of patients with methicillin resistant staphylococcal
infections managed with debridement and retention
of the prosthesis. Annual Scientific Meeting of the
Arthroplasty Society of Australia. Melbourne May 30
- June 2, 2012
Choong PF, Dowsey MM, Huang N, Stoney J.
Does the correlation between coronal alignment,
knee function and pain continue ? Annual Scientific
Meeting of the Arthroplasty Society of Australia.
Melbourne May 30 - June 2, 2012
Choong PF, Dowsey MM. The economic burden of
obesity in total knee replacement. Annual Scientific
Meeting of the Arthroplasty Society of Australia.
Melbourne May 30 - June 2, 2012
Dowsey, MM, Nikpour M, Dieppe P, Choong
PFM - Associations between pre-operative
radiographic changes and outcomes after total
knee joint replacement for osteoarthritis Australian
Rheumatology Association Annual Scientific Meeting
Oct 2012:, Melbourne
Peel T, Buising K, Cheng A, Choong P, The
Microbiological Aetiology, Epidemiology and Clinical
Profile of Prosthetic Joint Infections: are current
antibiotic prophylaxis guidelines effective? 22nd
ECCMID 2012 April 2012; United Kingdom
Choong PF. Megaprostheses – Lessons Learnt.
1stВ Oriental Orthopaedic Congress, Shanghai,
ChinaВ July 27-29, 2012
st vincent’s research report 2012
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University of Melbourne department of surgery
Broadhead ML, Myers DE, Choong PFM. Applying
advanced imaging techniques to a murine model of
orthotopic osteosarcoma for the evaluation of PEDF
therapy. Australian Orthopaedic Association Annual
Scientific Congress, October 2012
Thompson E. Epithelial mesenchymal plasticity in
xenograft models of circulating and disseminated
tumour cells from human breast cancer. American
Association for Cancer Research Annual Meeting.
Chicago, IL, USA, April 2012
Broadhead ML, Myers DE, Choong PFM The
application of in vivo bioluminescent imaging, PET
and micro-CT to a murine model of orthotopic
osteosarcoma. Australasian Sarcoma Study Group
Annual Meeting, Sydney, October 2012
Thompson E. Epithelial mesenchymal plasticity
(EMP) in breast cancer dissemination and
metastasis. Sydney Cancer Conference, Sydney,
NSW, Sept 2012.
Ye K, Felimban R, Di Bella C, Crook J, Quigley A,
Kapsa R, Choong P, Myers DE. Chondrogenesis of
adipose stem cells derived from infrapatellar fat pad
Australian Orthopaedic Association, Annual General
Meting, Lorne, 24th Feb 2012
DE Myers, R Felimban, K Ye, C Di Bella, J Foroughi,
J Chung, SE Moulton, A Quigley, J Crook, R Kapsa,
GG Wallace and PFM Choong. 3rd Asia-Pacific
Bionics Meeting, Production of hyaline cartilage in
3D chitosan scaffolds using infrapatellar fat pad stem
cells as the source of chondrocyte lineage cells,
September 2012
Thompson E. Coordinated induction of Laminin-332
subunits in breast cancer epithelial mesenchymal
transition. Matrix Biology Society of Australia & New
Zealand. Gold Coast, QLD, Sept 2012
Thompson E. Multiple modes of regulation of
epithelial mesenchymal plasticity in breast cancer.
John Curtin School of Medical Research ANU.
Canberra, ACT, June 2012
Thompson E. Epithelial mesenchymal plasticity
(EMP) in breast cancer dissemination- What to target
and when? Cell Plasticity in cancer evolution. Cold
Spring Harbor Laboratories, Banbury, Nov 2012
Thompson E. Epithelial mesenchymal plasticity
and metastasis. Herrenhausen Symposium on
Metastasis, Kloster Seeon, Seeon, Germany, Oct
2012
Thompson E. 21st Annual Meeting of the Japanese
Association of Metastasis Research. Hiroshima,
Japan, July 2012 (Session chair and Dinner
presentation)
Thompson E. Epithelial mesenchymal plasticity
in human breast cancer xenografts- Therapeutic
implications. Institute for Cancer Research. London,
England July 2012
Thompson E. Epithelial mesenchymal plasticity
(EMP) in xenograft models of human breast cancer
dissemination and metastasis. The Research
Institute, Osaka medical Center for Cancer and
Cardiovascular Diseases. Osaka, Japan, July 2012
st vincent’s research report 2012
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Victorian Cancer
CytogeneticsВ Service
The Victorian Cancer Cytogenetics Service
is a statewide reference centre for cancer
cytogenetics. Its primary research interest
involves investigating the genetics of leukaemias
and other haematological malignancies with
theВ aim of identifying better targets for therapy.
About us
The Victorian Cancer Cytogenetics Service (VCCS)
analyses the chromosome abnormalities of cancer
cells. Our research program focusses on how
specific chromosome rearrangements lead to the
development of leukaemia. These studies include
identifying which genes are lost from cancer cells
and which genes are present in increased numbers
– recent studies suggest that gain of one gene and
loss of another may interact to drive the formation
of leukaemia. We are also investigating which types
of therapy may cause myelodysplastic syndrome
(MDS – a type of pre-leukaemia that is increasingly
common in older patients) cells to die in culture
andВ whether their response to therapy is determined
byВ the type of chromosome abnormality observed
inВ the MDS cells. This work has the potential to
predict which combinations of drugs will be most
effective in different types of MDS – particularly
needed as these patients are elderly and tolerate
conventional chemotherapy very poorly.
Major projects
An ongoing project was continued by
DrВ RuthВ MacKinnon to investigate the genetic
rearrangements in cancer cells from patients with
acute myeloid leukaemia (AML) and myelodysplastic
syndromes (MDS). Dr MacKinnon used new array
techniques together with fluorescence in situ
hybridization (FISH) to determine the chromosome
abnormalities in cases with very complex abnormalities
and showed that most of these cases contain
chromosomes with two centromeres, a highly unusual
finding. She is continuing her study of these cases
to determine how such abnormalities cause normal
cells to become leukaemia cells.
Dr Meaghan Wall performed comprehensive genetic
characterisation of samples from patients with MDS
using single nucleotide polymorphism microarray
(SNP-A) testing and whole exome or whole genome
massively parallel sequencing technologies and
is correlating her findings with the in vitro drug
responsiveness of cells from the same patients to
hypomethylating agents (currently standard of care)
as well as to novel therapies. She has found that
karyotypic complexity as determined by conventional
karyotyping in combination with SNP-A abnormalities
correlates with the in vitro sensitivity of MDS cells to
treatment with hypomethylating agents suggesting
that is may be a predictive biomarker for disease
responsiveness.
Staff
Dr Ruth MacKinnon, Research Officer 0.8 EFT
Dr Meaghan Wall, Clinical Research Fellow. 0.75 EFT
Students
Dr Matthew Ku, PhD student 1.0 EFT
(co-supervised with Prof Harshal Nandurkar,
Department of Medicine)
Service to the wider community
A/Prof Lynda Campbell: Member, Australian
Government Department of Health and Ageing
Genetics Working Party; Member, RCPA Overseas
Trained Specialist (OTS) Sub-committee;
Member, RCPA Pathology Units and Terminology
Standardisation (PUTS) Project Genetic Pathology
Working Group; Advisor to RCPA Genetics
Curriculum Working Group; Member, Haematology
Committee, VCOG, Cancer Council of Victoria.
Mrs Fran O’Malley: Member of the Human Genetics
Society of Australasia (HGSA) Cytogenetics Board
of Censors and an assessor for the HGSA Quality
Assurance Program.
Dr Meaghan Wall: Member, RCPA Bone
MarrowВ Biopsy Structured Reporting Protocol
ExpertВ ReviewВ Committee.
Grants
Giles, G, Vajdic, C, Prince, M, Harrison, S,
Joshua, D, Campbell, L
The Epidemiology Of Multiple Myeloma In Australia
(Emma), NHMRC
$1,445,512.50 for 2012–2016 ($289,100 in 2012)
st vincent’s research report 2012
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Victorian Cancer CytogeneticsВ Service
Wall, M, MacKinnon, R
Dicentric chromosomes: tools for oncogene
discovery and their potential role as a principal cause
of unbalanced translocations in myeloid malignancy,
ANZ Medical Research and Technology in Victoria –
James and Vera Lawson Trust.
$30,000 for 2012
MacKinnon, R
Microscope upgrade, Rebecca Cooper Foundation
$22,000 for 2012
MacKinnon, R, White, J, Wall, M, Choong, P,
Campbell, L
Identifying genetic changes in soft tissue sarcoma,
St Vincent’s Hospital Research Endowment Fund
$20,000 for 2013 ($0 in 2012)
MacKinnon, R
Zeiss Microscope Adapter, Eirene Lucas Foundation
$5,737 for 2012
Wall, M
Myelodysplastic syndromes: molecular
characterisation and investigation of novel therapies,
Victorian Cancer Agency
$599,584 for 2009–2013 ($149,896 in 2012)
Purton LE, Baker E, Parker M, Wall M
The involvement of HOXA1 in myeloid neoplasia,
Leukaemia Foundation
$100,000 for 2012
Collaborations in research
International
Chin, L. K., Cheah, C. Y., Michael, P. M.,
MacKinnon, R. N., & Campbell, L. J. (2012). 11q23
rearrangement and duplication of MLLT1-MLL gene
fusion in therapy-related acute myeloid leukemia.
Leuk Lymphoma, 53(10), 2066–2068.
Cherry, A.M., Slovak, M.L., Campbell, L.J., Chun, K.,
Eclache, V., Haase, D., Haferlach, C., Hildebrandt,
B., Iqbal, A.M., Jhanwar, S.C., Ohyashiki, K.,
Sole, F., Vandenberghe, P., VanDyke, D.L., Zhang,
Y., Dewald, G.W. Will a peripheral blood (pb)
sample yield the same diagnostic and prognostic
cytogenetic data as the concomitant bone marrow
(BM) in Myelodysplasia? An international study
comparing cytogenetics and interphase FISH using
parallel PB and BM samples. Leukemia Research
2012 Jul;36(7):832–40. Epub 2012 Apr 25.
Bywater, M. J., Poortinga, G., Sanij, E., Hein, N.,
Peck, A., Cullinane, C., Wall, M., et al. (2012).
Inhibition of RNA polymerase I as a therapeutic
strategy to promote cancer-specific activation of
p53. Cancer Cell, 22(1), 51–65.
Hoctor, V., Campbell, L.J. Hyperhaploidy in plasma
cell myeloma. Cancer Genetics, 2012 Jul;205(7–
8):414–8.
Wall, M., Rayeroux, K. C., MacKinnon, R. N.,
Zordan, A., & Campbell, L. J. (2012). ETV6 deletion
is a common additional abnormality in patients
with myelodysplastic syndromes or acute myeloid
leukemia and monosomy 7. Haematologica, 97(12),
1933–1936.
• Cancer Council Victoria
White, J.S., Zordan, A., Batzios, C., Campbell,
L.J. Del(20q) as a Sole Abnormality in Plasma Cell
Myeloma is not Associated with Plasma Cells as
Identified by cIg FISH. Cancer Genetics, 2012 Nov
29: 205: 644–652 [Epub ahead of print].
Publications
Speaking engagements
Journal articles
Wall, M., Zordan, A., MacKinnon, R.N., Campbell,
L.J. A Feasibility and Utility Study of DNA Microarray
Testing in Acute Lymphoblastic Leukaemia. ASoC
2012 Annual Scientific Meeting 23–25 March 2012
• Signature Genomics, Spokane, Washington, USA
National
MacKinnon, R.N., Selan, C., Zordan, A., Wall,
M., Nandurkar, H., Campbell, L.J. CGH and SNP
array using DNA extracted from fixed cytogenetic
preparations and long-term refrigerated bone
marrow specimens. Molecular Cytogenetics 2012,
Feb 5 (1):10 doi:10.1186/1755–8166–5–10 [Epub
ahead of print].
*Campbell, L.J. Complex karyotypes in acute
myeloid leukaemia. Haematology Society of Australia
and New Zealand Queensland State Branch Annual
Scientific Meeting, Brisbane, 17 March 2012
st vincent’s research report 2012
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Victorian Cancer CytogeneticsВ Service
Friebe, A., Zordan, A., Campbell, L.J., Wall, M. The
Routine Detection of Cytogenetic Abnormalities in
Plasma Cell Myeloma: Local Experience over a FiveYear Period. Haematology Society of Australia and
New Zealand Annual Scientific Meeting, Melbourne,
28–31 October 2012 (poster)
Ku, M., Narayan, N., MacKinnon, R., Wall, M.,
Campbell, L., Nandurkar, H. Identification and
analysis of oncogenic pathways in deletion 20q
acute myeloid leukaemia. Haematology Society
of Australia and New Zealand Annual Scientific
Meeting, Melbourne, 28–31 October 2012 (poster)
Wall, M., MacKinnon, R.N., Zordan, A., Campbell,
L.J. Cytogenetic assessment of acute lymphoblastic
leukaemia is enhanced by the addition of DNA
microarray testing. Haematology Society of Australia
and New Zealand Annual Scientific Meeting,
Melbourne, 28–31 October 2012 (oral presentation)
Joshua, D.E., Hertzberg, M.S., Auguston, B.,
Spencer, A., Horvath, N., Bashford, J., Campbell,
L.J., Ashurst, E., Wade, J., Copeman, M.C.,
Butcher, B.E., Prince, H.M. Bortezomib–Based
Induction Overcomes Effect of 1q Amplification
On Response in Newly-Diagnosed Myeloma and
Results in Similar 2 Year Event-Free Survival.
American Society of Hematology Annual Scientific
Meeting, Altlanta, 8–11 December 2012 (poster)
Schultz,R.A., Brown, T.C., Campbell, L.J., Wall,
M., Schoumans, J., Han, J.Y., Surti, U., Stewart,
S.D., Fang, M., Fink, J.M., Tubbs, R.R., Cook,
J.R., Gitelson, E., McDaniel, L.D., Shaffer, L.G.,
Ballif, B.C. Detection of Copy Number Alterations
in DNA Repair/Repair-Related Genes for a Diversity
of Hematologic Malignancies Identifies DiseaseSpecific Biomarkers of Potential Clinical Relevance.
American Society of Hematology Annual Scientific
Meeting, Altlanta, 8–11 December 2012 (poster)
Wall, M., MacKinnon, R.N., Zordan, A., Campbell,
L.J. Detection of karyotypic abnormalities in
myelodysplastic syndromes by combined use
of single nucleotide polymorphism arrays and
metaphase cytogenetic testing. Haematology
Society of Australia and New Zealand Annual
Scientific Meeting, Melbourne, 28–31 October 2012
(oral presentation)
Wall, M., Campbell, L.J. Molecular genetics of
myeloproliferative neoplasms. Haematology Society
of Australia and New Zealand Annual Scientific
Meeting, Melbourne, 28–31 October 2012
Ku, M., MacKinnon, R.N., Wall, M., Campbell,
L.J., Nandurkar, H. Identification and Analysis of
Oncogenic Pathways in Deletion 20q Acute Myeloid
Leukaemia. American Society of Hematology Annual
Scientific Meeting, Altlanta, 8–11 December 2012
(poster)
Wall, M., MacKinnon, R.N., Zordan, A., Campbell,
L.J. Addition of the mTOR Inhibitor Rapamycin
Deepens Response to HDAC Inhibition or
Hypomethylating Therapy in Myelodysplastic
Syndromes. American Society of Hematology
Annual Scientific Meeting, Altlanta, 8–11 December
2012 (poster)
st vincent’s research report 2012
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Curtin Correspondence – March 2015

LCTV Programming Schedule - Lockport Community Television

CONSILIENCE - Connoisseur Wines

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