Staph Infection in Dogs Staphage Lysate (SPL)® is an all natural staphylococcal biologic effective in providing longterm control of a persistent staphylococcal skin infection in dogs, frequently called recurrent canine pyoderma. SPL stimulates the natural immune system of the dog, thereby reducing the recurrences of infection and eliminating the need for repetitive use of antibiotics. Treating recurrent canine pyoderma with round after round of antibiotics can be frustrating for the veterinarian, onerous and expensive for the dog owner and stressful for the dog. What is Staphage Lysate (SPL) Staphage Lysate (SPL)®, Staphylococcus Aureus Phage Lysate – is a sterile staphylococcal biologic containing the components of S.aureus; and a bacteriophage. It is manufactured in the US by Delmont Laboratories and does not contain any chemical preservatives. It is the only staphylococcal product of its kind approved for canine use that can reduce the recurrences of infection and stimulate the immune system simultaneously. It is not a shortterm medication but rather designed to help control the skin infection over time. How Staphage Lysate (SPL)® works SPL is believed to control pyoderma by enhancing the patient’s immune responses to staphylococcal species. Over the past 15 years, evidence from dozens of leading laboratories has shown that humans and animals have an “innate immune system” that allows the patient to react within minutes of exposure to several molecules that are present exclusively in pathogens (bacteria, viruses and fungi). Though these innate immune reactions are diverse and complex, all of them are initiated, focused and/or sustained by the patient’s production of proteins called “cytokines.” SPL contains several of the most powerful known stimulators of cytokines, including bacterial DNA, peptidoglycan, and lipoteichoic acid. Numerous studies with SPL, in both cell culture and animal models, have shown that SPL rapidly stimulates production of cytokines. SPL’s efficacy is believed to be due to its powerful ability to stimulate cytokines that enhance the patient’s innate immune reactions against skin-associated bacteria (including staphylococcal strains) that cause or exacerbate pyoderma. When To Use Staphage Lysate (SPL)® SPL is indicated for the treatment of canine pyoderma and related staphylococcal hypersensitivity, or polymicrobial skin infections with a staphylococcal component. It is most effective in dogs with a history of recurrent pyoderma. Underlying conditions should be ruled out including demodicosis, flea allergy dermatitis and hypothyroidism. In addition, SPL has been shown to be effective in dogs with resistance to multiple antibiotics.’ About Delmont Labs Who we Are Delmont Laboratories, Inc. is a privately held company with its core focus in developing products that treat staphylococcal skin infection. We are committed to ongoing research to better understand and develop treatments for this condition and to protect dogs from recurrence and ensuing methicillin-resistant bacteria. Our product Staphage Lysate (SPL)® has proven highly effective in providing long-term control of this resistant condition. It is unique in that it is a whole bacterial cell preparation from common virulent Staph strains that have been solubilized through the use of polyvalent staphylococcal bacteriophage. We work collaboratively with veterinarians everywhere who treat staphylococcal skin infection. Our experience can be a valuable resource. We also provide direct access to a board certified veterinary dermatologist to answer any questions and guide you through the treatment process. We recognize the complexity and challenges surrounding diagnosis and treatment of this condition. Our History Staphage Lysate (SPL)® was licensed for human use in 1959 in the United States. The utility of bacteriophage and the lysates in the treatment of staphylococcal infections was reported by Robert Lincoln, MD in 1948. He also recognized that the staphylococcal phage lysates were particularly useful in the treatment of immune compromised patients and patients with chronic skin infections such as furunculosis and folliculitis. Dr. Lincoln helped found Lincoln Laboratories that is now known as Delmont Laboratories. In 1986 Delmont Laboratories applied to the U. S. Department of Agriculture for a veterinary license for the use of Staphage Lysate (SPL)® in the treatment of recurrent canine pyoderma. (USDA True Name: Staphylococcus aureus Phage Lysate). The USDA license was issued in 1987. (Note: Staphage Lysate (SPL)® is not currently sold for human use). Delmont Laboratories has subsequently obtained veterinary licenses in Canada (English speaking 1992, French speaking 2000) and in Brazil (2001). Typical evolution of superficial staphylococcal pyoderma in dogs Early in the course of allergic disease, many dogs will have few or no lesions, though itch may be severe. This dog’s abdomen is erythematous and very pruritic, though secondary infection has not set in yet. As inflammation and self-trauma persist, there is increasing alopecia and erythema, along with the beginning signs of superficial pyoderma. This dog’s axilla is developing numerous small erythematous papules suggestive of early infection, though overt pustules have not yet developed. As the staphylococcal infection becomes firmly established, pustules begin to appear, as shown on this dog’s abdomen. As the infection progresses, the pustules enlarge and rupture, creating focal crusted lesions and spreading out to form circular “epidermal collarettes.” As the epidermal collarettes heal, they often become hyperpigmented in the center. Note in this dog many circular black “spots” indicating healed former collarettes, some collarettes in the process of healing, and some that appear to be just forming. In this case, we can say that the superficial staphylococcal infection has been present for some time. For more information please visit http://www.delmontlabs.com
Staphage Lysate (SPL)® is an all natural staphylococcal biologic effective in providing long-term control of a persistent staphylococcal skin infection in dogs, frequently called recurrent canine pyoderma. SPL stimulates the natural immune system of the dog, thereby reducing the recurrences of infection and eliminating the need for repetitive use of antibiotics. Treating recurrent canine pyoderma with round after round of antibiotics can be frustrating for the veterinarian, onerous and expensive for the dog owner and stressful for the dog.
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