CorsI di Laurea DELLA ClassI lm-13 E L-29 Diana CONTE

CorsI di Laurea DELLA ClassI lm-13 E
L-29
Diana CONTE
Curriculum vitae
Professore Ordinario di Farmacologia e Farmacoterapia dal 1994 presso l’Università degli Studi
di Bari “Aldo Moro”.
Incarichi Accademici e Scientifici
Dal 2007 al 2009: Membro del Consiglio Direttivo della Società Italiana di Farmacologia. Dal 2007:
Presidente del Comitato Etico della A.S.L., Lecce. Dal 2008 a tutt’oggi: Membro del Senato
Accademico dell’Università degli Studi di Bari “Aldo Moro”. Dal 2011: Direttore del Corso di
Perfezionamento "Farmacista di Reparto" e Coordinatore del dottorato in “Biochimica Cellulare e
Farmacologia Cellulare”.
Riconoscimenti alla Carriera
Nel 2012 é stata insignita del Premio Nazionale “l’altra Italia – Vite da Premio – sezione Ricerca
Scientifica” per il successo alla carriera. Nel 2014, Premio “Storie di donne”, per il settore Medicina.
Finanziamenti di Ricerca
Dal 1972 responsabile di vari progetti di ricerca finanziati da CNR, MIUR (FIRB, PRIN), ASI
(Agenzia Spaziale Italiana), Regione Puglia, AFM (Association Française contre les Myopathies),
Cassa di Risparmio di Puglia. Dal 1991 ad oggi ha ricevuto finanziamenti dalla Fondazione Telethon
per studi nel campo delle malattie rare, delle malattie genetiche e canalopatie e nell’identificazione di
nuove terapie farmacologiche.
Principali campi d’interesse scientifico
Studi di farmacologia, biofisica e biologia molecolare di canalopatie genetiche (renali, muscolari,
pancreatiche) ed acquisite. Studi preclinici in-vivo ed ex-vivo delle suddette patologie.
Attività di Reviewer
Reviewer per proposte di finanziamenti di ricerca (tra gli altri): Expert Panel on Health and Sciences,
European Community (1991−94); Expert panel at Biomed 2 for Rare Diseases, Ageing and Orphan
Drugs, European Community (1997); The Welcome Trust, UK (diverse volte dal 1997); The Medical
Research Council, UK (2012); Association Française contre les Myopathies, France (dal 1996);
Federazione Italiana Sclerosi Multipla, Italy (dal 2004)
Reviewer per numerose riviste scientifiche tra cui: Acta Physiologica; Canadian Journal of
Physiology and Pharmacology; Clinical Endocrinology; European Journal of Clinical Investigation;
European Journal of Physiology; Journal of Neurobiology; Experimental Neurology; Journal of
Membrane Biology; Journal of Pharmacology and Experimental Therapeutics; Journal of
Physiology; Molecular Pharmacology; Nature Communications; Naunyn Schmiedeberg's Archives of
Pharmacology; Neurobiology of Disease; Neuromuscular Disorders; Neuroscience Letters;
Pharmacological Research
Attività Editoriale
Specialty Chief Editor di Frontiers in Pharmacology of Ion Channels and Channelopathies. Membro
dell’Editorial Board della rivista scientifica Neuromuscular Disorders
Pubblicazioni
Dal 1971, ha pubblicato più di 200 articoli su riviste internazionali a comitato di lettura.
Pubblicazioni su riviste, brevetti e monografie ultimo decennio
(Dal 2004 al 2014)
1. Desaphy J-F, De Luca A, Didonna MP, George AL Jr, Conte Camerino D. Different flecainide
sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block. J
Physiol 554: 321-334, 2004.
2. Liantonio A, Pusch M, Picollo A, Guida P, De Luca A, Pierno S, Fracchiolla G, Loiodice F,
Tortorella P, and D Conte Camerino. Investigations of pharmacologic properties of the renal
CLC-K1 chloride channel co-expressed with barttin by the use of 2-(pChlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels
blockers. J Am Soc Nephrol 15(1): 13-20, 2004.
3. Catalano A, Carocci A, Fracchiolla G, Franchini C, Lentini G, Tortorella V, De Luca A, De
Bellis M, Desaphy J-F, and D Conte Camerino. Stereospecific synthesis of “parahydroxymexiletine” and sodium channel blocking activity evaluation. Chirality 16: 72-78, 2004.
4. Tricarico D, Barbieri M, Mele A, Carbonara G, and D Conte Camerino. Carbonic anhydrase
inhibitors are specific openers of skeletal muscle BK channel of K +-deficient rats. FASEB J
18(6): 760-761, 2004.
5. Conte Camerino D, Tricarico D, Pierno S, Desaphy J-F, Liantonio A, Pusch M, Burdi R,
Camerino C, Fraysse B, and A De Luca. Taurine and skeletal muscle disorders. Neurochem Res
29: 135-142, 2004.
6. Picollo A, Liantonio A, Didonna MP, Elia L, Conte Camerino D, and M Pusch. Molecular
determinants of differential pore blocking of kidney CLC-K chloride channels. EMBO Rep
5(6): 584-589, 2004.
7. De Luca A, Pierno S, Liantonio A, Desaphy J-F, Natuzzi F, Didonna MP, Ferrannini E,
Jockusch H, Franchini C, Lentini G, Corbo F, Tortorella V, and D Conte Camerino. New
potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents
on myotonic ADR mouse. Neuromuscul Disord 14: 405-416, 2004.
8. De Salvatore G, Desaphy J-F, Piepoli AL, Natale L, De Salvia MA, Mitolo CI, Renna G, Conte
Camerino D, and D Mitolo-Chieppa. Functional alterations of mesenteric vascular bed, vas
deferens and intestinal tracts in a rat hindlimb unloading model of microgravity. Autonom
Autacoid Pharmacol 24: 45-54, 2004.
9. Fraysse B, Liantonio A, Cetrone M, Burdi R, Pierno S, Frigeri A, Pisoni M, Camerino C, De
Luca A. The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is
worsened by a chronic exercise in vivo. Neurobiol Dis 17(2):144-54, 2004.
10. De Luca A, Nico B, Liantonio A, Didonna MP, Fraysse B, Pierno S, Burdi R, Mangieri D,
Rolland JF, Camerino C, Zallone A, Confalonieri P, Andreetta F, Arnoldi E, Courdier-Fruh I,
Magyar JP, Frigeri A, Pisoni M, Svelto M, and D Conte Camerino. A multidisciplinary
evaluation of the effectiveness of cyclosporine a in dystrophic mdx mice. Am J Pathol 166(2):
477-489, 2005.
11. Desaphy J-F, Pierno S, Liantonio A, De Luca A, Frigeri A, Nicchia GP, Svelto M, Camerino C,
Zallone A, and D Conte Camerino. Recovery of the soleus muscle after short- and long-term
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disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy
chain profile. Neurobiol Dis 18: 356-365, 2005.
12. Tricarico D, Mele A, and D Conte Camerino. Phenotype-dependent functional and
pharmacological properties of BK channels in skeletal muscle: effects of microgravity.
Neurobiol Dis 20(2): 296-302, 2005.
13. Fraysse B, Desaphy J-F, Rolland J-F, Pierno S, Liantonio A, Giannuzzi V, Camerino C,
Didonna MP, Cocchi D, De Luca A, Conte Camerino D. Fiber type-related changes in rat
skeletal muscle calcium homeostasis during aging and restoration by growth hormone.
Neurobiol Dis 21: 372-380, 2006.
14. Liantonio A, Picollo A, Babini E, Carbonara G, Fracchiolla G, Loiodice F, Tortorella V, Pusch
M, Conte Camerino D. Activation and inhibition of kidney CLC-K chloride channels by
fenamates. Mol Pharmacol 69(1): 165-173, 2006.
15. Tricarico D, Mele A, Conte Camerino D. Carbonic anhydrase inhibitors ameliorate the
symptoms of hypokalaemic periodic paralysis in rats by opening the muscular Ca 2+-activated-K+
channels. Neuromuscul Disord 16(1): 39-45, 2006.
16. Tricarico D, Mele A, Lundquist AL, Desai RR, George AL Jr, Conte Camerino D. Hybrid
assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical
and pharmacological properties. Proc Natl Acad Sci U S A 103(4): 1118-1123, 2006.
17. De Bellis M, De Luca A, Rana F, Cavalluzzi MM, Catalano A, Lentini G, Franchini C,
Tortorella V, Conte Camerino D. Evaluation of the pharmacological activity of the major
mexiletine metabolites on skeletal muscle sodium currents. Br J Pharmacol 149(3): 300-310,
2006.
18. Rolland JF, De Luca A, Burdi R, Andreetta F, Confalonieri P, Conte Camerino D. Overactivity
of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native
muscle fibers: Beneficial effect of pentoxifylline. Neurobiol Dis 24: 466-474, 2006.
19. Rolland JF, Tricarico D, Laghezza A, Loiodice F, Tortorella V, Conte Camerino D. A new
benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue
selectivity in vitro and hypoglycaemic action in vivo. Br J Pharmacol 149: 870-879, 2006.
20. Pierno S, Didonna MP, Cippone V, De Luca A, Pisoni M, Frigeri A, Nicchia GP, Svelto M,
Chiesa G, Sirtori C, Scanziani E, Rizzo C, De Vito D, Conte Camerino D. Effects of chronic
treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and
electrophysiological study. Br J Pharmacol 149: 909-919, 2006.
21. Liantonio A, Giannuzzi V, Picollo A, Babini E, Pusch M, Conte Camerino D. Niflumic acid
inhibits chloride conductance of rat skeletal muscle by directly inhibiting the CLC-1 channel
and by increasing intracellular calcium. Br J Pharmacol 150: 235-247, 2007.
22. Liantonio A, Giannuzzi V, Cippone V, Camerino GM, Pierno S, Conte Camerino D,
Fluvastatin and atorvastatin affect calcium homeostasis of rat skeletal muscle fibers in vivo and
in vitro by impairing the sarcoplasmic reticulum/mitochondria Ca2+-release system. J
Pharmacol Exp Ther 321: 626-634, 2007.
23. Conte Camerino D, Tricarico D, and J-F Desaphy. Ion channel pharmacology. Neurother 4:
184-98, 2007.
24. Picollo A, Liantonio A, Babini E, Conte Camerino D, Pusch M. Mechanism of interaction of
niflumic acid with heterologously expressed kidney CLC-K chloride channels. J Membr Biol
216: 73-82, 2007.
25. Pierno S, Nico B, Burdi R, Liantonio A, Didonna MP, Cippone V, Fraysse B, Rolland JF,
Mangieri D, Andreetta F, Ferro P, Camerino C, Zallone A, Confalonieri P, De Luca A. Role of
tumour necrosis factor alpha, but not of cyclo-oxygenase-2-derived eicosanoids, on functional
and morphological indices of dystrophic progression in mdx mice: a pharmacological approach.
Neuropathol Appl Neurobiol 33(3):344-59, 2007.
26. Bruno C., Catalano A., Desaphy J.-F., Cavalluzzi M.M., Carocci A., Dipalma A., Franchini C.,
Lentini G., Conte Camerino D. and V. Tortorella. Pilsicainide and its oxymethylene analog:
Facile alternative synthesis and in vitro testing on human skeletal muscle sodium channels.
Heterocycles 71(9): 2011-2026, 2007.
27. Pierno S, Desaphy J-F, Liantonio A, De Luca A, Zarrilli A, Mastrofrancesco L, Procino G,
Valenti G, Conte Camerino D. Disuse of rat muscle in vivo reduces protein kinase C activity
controlling the sarcolemma chloride conductance. J Physiol 584: 983-995, 2007.
28. Tricarico D, Mele A, Liss B, Ashcroft FM, Lundquist AL, Desai RR, George AL Jr, Conte
Camerino D. Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+depleted rats. Neuromuscul Disord 18: 74-80, 2008.
29. Liantonio A, Picollo A, Carbonara G, Fracchiolla G, Tortorella P, Loiodice F, Laghezza A,
Babini E, Zifarelli G, Pusch M, Conte Camerino D. Molecular switch for CLC-K Cl- channel
block/activation: Optimal pharmacophoric requirements towards high-affinity ligands. Proc
Natl Acad Sci U S A. 105: 1369-73, 2008.
30. Tricarico D, Lovaglio S, Mele A, Rotondo G, Mancinelli E, Meola G, Conte Camerino D.
Acetazolamide prevents vacuolar myopathy in skeletal muscle of K(+)-depleted rats. Br J
Pharmacol 154: 183-190, 2008.
31. Catalano A, Carocci A, Corbo F, Franchini C, Muraglia M, Scilimati A, De Bellis M, De Luca
A, Conte Camerino D, Sinicropi MS, Tortorella V. Constrained analogues of tocainide as
potent skeletal muscle sodium channel blockers towards the development of antimyotonic
agents. Eur J Med Chem 43: 2535-2540, 2008.
32. Tricarico D, Mele A, Camerino GM, Laghezza A, Carbonara G, Fracchiolla G, Tortorella P,
Loiodice F, Conte Camerino D. Molecular determinants for the activating/blocking actions of
the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the
skeletal muscle KATP channels. Mol Pharmacol 74: 50-58, 2008.
33. De Luca A, Nico B, Rolland J-F, Cozzoli A, Burdi R, Mangieri D, Giannuzzi V, Liantonio A,
Cippone V, De Bellis M, Nicchia GP, Camerino GM, Frigeri A, Svelto M, Conte Camerino D.
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Gentamicin treatment in exercised mdx mice: identification of dystrophin-sensitive pathways
and evaluation of efficacy in work-loaded dystrophic muscle. Neurobiol Dis 32: 243-253, 2008.
34. Frigeri A, Iacobas DA, Iacobas S, Nicchia GP, Desaphy J-F, Conte Camerino D, Svelto M.
Effect of microgravity on gene expression in mouse brain. Exp Brain Res 191: 289-300, 2008.
35. Conte Camerino D, Desaphy J-F, Tricarico D, Pierno S, Liantonio A. Therapeutic approaches
to ion channel diseases. Adv Genet 64: 81-145, 2008.
36. Pierno S, Camerino GM, Cippone V, Rolland J-F, Desaphy J-F, De Luca A, Liantonio A,
Bianco G, Kunic JD, George AL Jr, Conte Camerino D. Statins and fenofibrate affect skeletal
muscle chloride conductance in rats by differently impairing ClC-1 channel regulation and
expression. Br J Pharmacol 156: 1206-1215, 2009.
37. Desaphy J-F, Dipalma A, De Bellis M, Costanza T, Gaudioso C, Delmas P, George AL Jr,
Conte Camerino D. Involvement of voltage-gated sodium channels blockade in the analgesic
action of orphenadrine. Pain 142(3): 225-235, 2009.
38. Liantonio A, Pierno S, Digennaro C, Giannuzzi V, Gramegna G, Desaphy J-F, Conte
Camerino D. The hindlimb unloading model of microgravity differently affects skeletal muscle
properties of young and adult mice. Basic Applied Myology 19 (2&3): 107-112, 2009.
39. Betto R, Franzoso S, Sandonà D, Danieli-Betto D, Balistreri M, Picard A, Furlan S, Salvatori S,
Desaphy J-F, Pierno S, Camerino GM, Dobrowolny G, Musarò A, Conte Camerino D,
Schiaffino S. On ground preflight studies on skeletal muscle from mice kept in the Mouse
Drawer System (MDS). Basic Applied Myology 19 (2&3): 97-106, 2009.
40. Fracchiolla G, Laghezza A, Piemontese L, Tortorella P, Mazza F, Montanari R, Pochetti G,
Lavecchia A, Novellino E, Pierno S, Conte Camerino D, Loiodice F. New 2-aryloxy-3-phenylpropanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with
improved potency and reduced adverse effects on skeletal muscle function. J Med Chem
52(20): 6382-93, 2009.
41. Brocca L, Pellegrino MA, Desaphy J-F, Pierno S, Conte Camerino D, Bottinelli R. Oxidative
stress: a consequence or a cause of disuse muscle atrophy in mice ? A proteomic approach in
hindlimb unloaded and antioxidant treated mice. Exp. Physiol. 95: 331-350, 2010.
42. Carocci A, Catalano A, Bruno C, Lentini G, Franchini C, De Bellis M, De Luca A, Conte
Camerino D. Synthesis and in vitro sodium channel blocking activity evaluation of novel
homochiral mexiletine analogs. Chirality 22(3): 299-307, 2010.
43. Tricarico D, Mele A, Camerino GM, Bottinelli R, Brocca L, Frigeri A, Svelto M, George AL Jr,
Conte Camerino D. The KATP channel is a molecular sensor of atrophy in skeletal muscle. J
Physiol 588: 773-784, 2010.
44. Desaphy J-F, Pierno S, Liantonio A, Giannuzzi V, Digennaro C, Dinardo MM, Camerino GM,
Ricciuti P, Brocca L, Pellegrino MA, Bottinelli R, Conte Camerino D. Antioxidant treatment
of hindlimb-unloaded mouse counteracts fiber type transition but not atrophy of disused
muscles. Pharmacol Res 61: 553-63, 2010.
45. Catalano A, Carocci A, Cavalluzzi MM, Di Mola A, Lentini G, Lovece A, Dipalma A, Costanza
T, Desaphy J-F, Conte Camerino D, Franchini C. Hydroxylated analogs of mexiletine as tools
for structural requirements: Investigation of sodium channel blocking activity. Arch Pharm
343: 325-332, 2010.
46. Desaphy J-F, Dipalma A, Costanza T, Bruno C, Lentini G, Franchini C, George AL Jr, Conte
Camerino D. Molecular determinants of state-dependent block of voltage-gated sodium
channels by pilsicainide. Br J Pharmacol 160(6): 1521-1533, 2010.
47. Ghelardini C, Desaphy J-F, Muraglia M, Corbo F, Matucci R, Dipalma A, Bertucci C, Pistolozzi
M, Nesi M, Norcini M, Franchini C, Conte Camerino D. Effects of a potent analog of tocainide
on hNav1.7 sodium channels and in vivo pain models: a potential candidate for treatment of
neuropathic pain. Neuroscience 169(2): 863-873, 2010.
48. Conte Camerino D, Desaphy J-F. Grand challenge for ion channels: an underexploited re
source for therapeutics. Front Pharmacol 1(113):1-2, 2010.
49. Zifarelli G, Liantonio A, Gradogna A, Picollo A, Gramegna G, De Bellis M, Murgia AR, Babini
E, Conte Camerino D, Pusch M. Identification of sites responsible for the potentiating effect of
niflumic acid on ClC-Ka kidney chloride channels. Br J Pharmacol 160(7): 1652-1661, 2010.
50. Basco D, Nicchia GP, Desaphy J-F, Conte Camerino D, Frigeri A, Svelto M. Analysis by twodimensional Blue Native/SDS-PAGE of membrane protein alterations in rat soleus muscle after
hindlimb unloading. Eur J Appl Physiol 110: 1215-1224, 2010.
51. Pellegrino MA, Desaphy J-F, Brocca L, Pierno S, Conte Camerino D, Bottinelli R. Redox
homeostasis, oxidative stress and disuse muscle atrophy. J Physiol 589(9): 2147-2160, 2011.
52. Tricarico D, Conte Camerino D. Recent advance in the pathogenesis and drug actions in the
periodic paralyses and related channelopathies. Front Pharmacol 2(8):1-8, 2011.
53. Camerino GM, Pellegrino MA, Brocca L, Digennaro C, Conte Camerino D, Pierno S,
Bottinelli R. Statin or fibrate chronic treatment modifies the proteomic profile of rat skeletal
muscle. Biochem Pharmacol 81(8): 1054-1064, 2011.
54. De Luca A, De Bellis M, Corbo F, Franchini C, Muraglia M, Catalano A, Carocci A, Conte
Camerino D. Searching for novel anti-myotonic agents: Pharmacophore requirements for usedependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of
tocainide. Neuromuscul Disord 22: 56-65, 2012.
55. Pierno S, Liantonio A, Camerino GM, De Bellis M, Gramegna G, Cannone M, Simonetti S,
Nicchia GP, Basco D, Svelto M, Desaphy J-F, Conte Camerino D. Potential benefits of taurine
in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat.
Amino Acids 43(1):431-45, 2012.
56. Liantonio A, Gramegna G, Camerino GM, Dinardo MM, Scaramuzzi A, Potenza MA,
Montagnani M, Procino G, Lasorsa DR, Mastrofrancesco L, Laghezza A, Fracchiolla G,
Loiodice F, Perrone MG, Lopedota A, Conte S, Penza R, Valenti G, Svelto M, Conte
Camerino D. In vivo administration of CLC-K kidney chloride channels inhibitors increases
water diuresis in rats: a new drug target for hypertension ? J Hypertens 30: 153-167, 2012.
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57. Tricarico D, Rolland JF, Cannone G, Mele A, Cippone V, Laghezza A, Carbonara G,
Fracchiolla G, Tortorella P, Loiodice F, Conte Camerino D. Structural nucleotide analogs are
potent activators/inhibitors of pancreatic β cell KATP channels: an emerging mechanism
supporting their use as antidiabetic drugs. J Pharmacol Exp Ther 340(2): 266-76, 2012.
58. Catalano A, Desaphy J-F, Lentini G, Carocci A, Di Mola A, Bruno C, Carbonara R, De Palma
A, Budriesi R, Ghelardini C, Perrone MG, Colabufo NA, Conte Camerino D, Franchini C.
Synthesis and toxicopharmacological evaluation of meta-hydroxymexiletine, the first metabolite
of mexiletine more potent than the parent compound on voltage-gated sodium channels. J Med
Chem 55: 1418-1422, 2012.
59. Desaphy J-F, Dipalma A, Costanza T, Carbonara R, Dinardo MM, Catalano A, Lentini G,
Franchini C, Conte Camerino D. Molecular insights into the local anesthetic receptor within
voltage-gated sodium channels using hydroxylated analogs of mexiletine. Front Pharmacol
3(17): 1-12, 2012.
60. Sandonà D, Desaphy J-F, Camerino GM, Bianchini E, Ciciliot S, Danieli-Betto D, Dobrowolny
G, Furlan S, Germinario E, Goto K, Gutsmann M, Kawano F, Nakai N, Ohira T, Ohno Y,
Picard A, Salanova M, Schiffl G, Blottner D, Musarò A, Ohira Y, Betto R, Conte Camerino D,
Schiaffino S. Adaptation of mouse skeletal muscle to long-term microgravity in the MDS
mission. PlosOne 7(3): e33232, 2012.
61. Dinardo MM, Camerino GM, Mele A, Latorre R, Conte Camerino D, Tricarico D. Splicing of
the rSlo gene affects the molecular composition and drug response of Ca 2+-activated K+
channels in skeletal muscle. PlosOne 7(7): e40235, 2012.
62. Mele A, Buttiglione M, Cannone G, Vitiello F, Conte Camerino D, Tricarico D.
Opening/blocking actions of pyruvate kinase antibodies on neuronal and muscular KATP
channels. Pharmacol Res 66(5): 401-408, 2012.
63. Desaphy J-F, Modoni A, Lo Monaco M, Conte Camerino D. Dramatic improvement of
myotonia permanens with flecainide: a two-case report of a possible bench-to-bedside
pharmacogenetics strategy. Eur J Clin Pharmacol 69: 1037-1039, 2013.
64. Desaphy J-F, Costanza T, Carbonara R, Conte Camerino D. In vivo evaluation of antimyotonic
efficacy of β-adrenergic drugs in a rat model of myotonia. Neuropharmacol 65: 21-27, 2013.
65. De Bellis M, De Luca A, Desaphy J-F, Carbonara R, Heiny JA, Kennedy A, Carocci A,
Cavalluzzi M.M., Lentini G, Franchini C, Conte Camerino D. Combined modifications of
mexiletine pharmacophores for new lead blockers of Nav1.4 channels. Biophys J, 104(2): 344354, 2013.
66. Desaphy J-F, Carbonara R, Costanza T, Lentini G, Cavalluzzi MM, Bruno C, Franchini C,
Conte Camerino D. Molecular dissection of lubeluzole use-dependent block of voltage-gated
sodium channels discloses new therapeutic potentials. Mol Pharmacol 83(2): 406-415, 2013.
67. Imbrici P, Conte Camerino D, Tricarico D. Major channels involved in neuropsychiatric
disorders and therapeutic perspectives. Front Genet 4:76, 2013.
68. Brugnoni R, Kapetis D, Imbrici P, Pessia M, Canioni E, Colleoni L, Kerlero de Rosbo N,
Morandi L, Cudia P, Gashemi N, Bernasconi P, Desaphy J-F, Conte D, Mantegazza R. A large
cohort of myotonia congenita probands: novel mutations and a high-frequency mutation region
in exons 4 and 5 of the CLCN1 gene. J Hum Genet 58(9): 581-587, 2013.
69. Pierno S, Camerino GM, Cannone M, Liantonio A, Digennaro C, Gramegna G, De Luca A,
Germinario E, Danieli-Betto D, Betto R, Dobrowolny G, Rizzuto E, Musarò A, Desaphy J-F,
Conte Camerino D. Paracrine effects of IGF-1 overexpression in the functional decline due to
skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1
transgenic mice. PLoSOne 8(6): e65167, 2013.
70. Tricarico D, Mele A, Calzolaro S, Cannone G, Camerino GM, Dinardo MM, Latorre R, Conte
Camerino D. Emerging role of calcium-activated potassium channel in the regulation of cell
viability following potassium ions challenge in HEK293 cell and pharmacological modulation
PLoSOne 8(7): e69551, 2013.
71. Liantonio A, Gramegna G, Carbonara G, Sblendorio VT, Pierno S, Fraysse B, Giannuzzi V,
Rizzi L, Torsello A, Conte Camerino D. Growth hormone secretagogues exert differential
effects on skeletal muscle calcium homeostasis in male rats depending on the peptidyl/nonpeptidyl structure. Endocrinology 154(10): 3764-75, 2013.
72. Camerino GM, Pierno S, Liantonio A, De Bellis M, Cannone M, Sblendorio V, Conte E, Mele
A, Tricarico D, Tavella S, Ruggiu A, Cancedda R, Ohira Y, Danieli-Betto D, Ciciliot S,
Germinario E, Sandonà D, Betto R, Conte Camerino D, Desaphy J-F. Effects of pleiotrophin
overexpression on mouse skeletal muscles in normal loading and in actual and simulated
microgravity. PLoSOne 8(8): e72028, 2013.
73. Desaphy J-F, Gramegna G, Altamura C, Dinardo MM, Imbrici P, George AL Jr, Modoni A,
LoMonaco M, Conte Camerino D. Functional characterization of ClC-1 mutations from
patients affected by recessive myotonia congenita presenting with different clinical phenotypes.
Exp Neurol 248: 530-540, 2013.
74. Pierno S, Tricarico D, Liantonio A, Mele A, Digennaro C, Rolland J-F, Bianco G, Villanova L,
Merendino A, Camerino GM, De Luca A, Desaphy J-F, Conte Camerino D. An olive oil–
derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function. Age
(Dordr) 36(1):73-88, 2014.
75. Mele A, Calzolaro S, Cannone L, Cetrone M, Conte D, Tricarico D. Database search of
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76. Muraglia M, De Bellis M, Catalano A, Carocci A, Franchini C, Carrieri A, Fortugno C, Bertucci
C, Desaphy J-F, De Luca A, Conte Camerino D, Corbo F. N-Aryl-2,6-dimethylbenzamides, a
new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium
channels. J Med Chem 57: 2589-2600, 2014.
77. Desaphy J-F, Carbonara R, Costanza T, Conte Camerino D. Preclinical evaluation of marketed
sodium channel blockers in a rat model of myotonia discloses new potential antimyotonic drugs.
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79. Maffei M, Longa E, Qaisar R, Agoni V, Desaphy J-F, Conte Camerino D, Bottinelli R,
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regulation of the atrophy in different skeletal muscle phenotypes. Biochem Pharmacol 91: 26675, 2014
81. Imbrici P, Liantonio A, Gradogna A, Pusch M, Conte Camerino D. Targeting kidney CLC-K
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