Saving the White Lions: One Woman`s Battle for Africa`s Most Sacred

Curriculum Vitae
PERSONAL INFORMATION
Marcella Maddaluno
Marcella Maddaluno
Viale Vittorio Emanuele II, 54. Siena, 53100, Italy
347 1958066
[email protected]; [email protected]
Sex Female | Date of birth 28/06/1983| Nationality Italian
Qualification: Ph.D.
CURRENT POSITION
Nov 2012-Oct 2014
Research Fellow
Novartis Vaccines and Diagnostics (Siena, IT)
Vaccine development against microbial agents involved in infectious diseases
UNIVERSITY EDUCATION
2008-2011
Ph.D. in Pharmacology. Department of Experimental Pharmacology, University of
Naples Federico II. Thesis: Pathophisiological mechanisms and possible therapeutic
targets of vascular injury. Supervisor: Prof. A. Ialenti.
2005-2007
B.Sc. (Hons) in Pharmaceutical Biotechnology. Mark: 110 out of 110 “cum laude”.
Department of Experimental Pharmacology, University of Naples Federico II, Italy.
Thesis: The role of IL-18 in neointimal proliferation. Including 2 years of laboratory
training for the degree’s thesis
2002-2005
Bachelor Degree in Health Biotechnology. Mark: 110 out of 110 “cum laude”.
Department of Experimental Pharmacology, University of Naples Federico II, Italy.
Thesis: Immunohistochemical localization of IL-18 in rat carotid arteries after balloon
angioplasty. Including 3 months of laboratory training for the degree’s thesis.
PREVIOUS APPOINTMENTS
Feb-Jul 2012
Collaboration contract with Department of Experimental Pharmacology, University of
Naples Federico II. Project: Investigating the role of chemokines in injury-induced
vascular disease, by immunofluorescence.
Jul-Dec 2011
Research Fellow. Institute of Infection, Immunity and Inflammation, University of
Glasgow, UK, supported by Italian Society of Pharmacology. Project: Evaluation of
Antigen presentation by vascular smooth muscle cells. Supervisor: Prof. P. Garside.
2007-2008
2007
2003-2007
Research Fellow. Department of Experimental Pharmacology, University of Naples
Federico II, Italy. Project: Development of peptides, inhibiting NF-kB activation, as
potential pharmacological agents in the control of vascular injury. Supervisor: Prof. A.
Ialenti.
Degree’s awards: “Giovanni Guacci”. Department of Experimental Pharmacology,
University of Naples Federico II, Italy.
Store promotion activity at BI.VA. & Associati S.a.s. Castellammare Di
Stabia, Naples, Italy
PERSONAL SKILLS
Mother tongue(s)
Italian
© European Union, 2002-2012 | http://europass.cedefop.europa.eu
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Curriculum Vitae
Other language(s)
English
Communication skills
Organisational / managerial skills
Job-related skills
Marcella Maddaluno
UNDERSTANDING
SPEAKING
WRITING
Listening
Reading
Spoken interaction
Spoken production
C1
C1
C1
C1
C1
Working in a multicultural environment, in which adaptation and flexibility are important
Management of Research Laboratory; provision of training for personnel, planning and research,
monitoring of standard of performance
In vivo Models: Experimental models of Restenosis in mice and rats (balloon angioplasty, wire injury),
Atherosclerosis and Reendothelization, Immunization.
In vitro Models: Cell Cultures (primary and continuous cell lines) and bacteria. T and B cell Isolation.
Derivation of Macrophages and Dendritic cells from bone marrow. Vascular smooth muscle cell
explant. Chemotactic Migration Assay in transwell and Wound Healing. Invasion assay in Matrigel
Chambers. BrdU incorporation and MTT assay. Gel Zymography. NO2 production (Griess method).
Protein and nucleic acid extraction.
Immunochemical techniques: ELISA, Flow Cytometry, Meso Scale, Immunohistochemistry,
Immunofluorescence, Western-Blot
Istology and imaging: Confocal Microscopy. Fixation, embedding and processing tissue. Microtome
and cryostat cutting. Staining with Haematoxylin and Eosin, Picrosirius red, Oil red O.
Molecular Biology: Real Time PCR, RT-PCR, EMSA
Computer skills
Other skills
Driving licence
IC3 Certification (Internet and Compounding Core Certification), Service Consulting Srl, Torre
Annunziata, Naples, 17/03/05
Microsoft Office. Internet.
Applicative Software: Microscope Imaging Software (Leica and Zeiss). Statistical Analysis (Graph Pad)
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Playing classical guitar and electric bass
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Driving licence categories: B, A
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ADDITIONAL INFORMATION
Publications
Xiao Q; Zhang F; Grassia G; Hu Y; Zhang Z; Xing Q; Yin X; Maddaluno M; Drung B; Schmidt B;
Maffia P; Ialenti A; Mayr M; Xu Q; Ye S. Matrix Metalloproteinase-8 Promotes Vascular Smooth
Muscle Cell Proliferation and Neointima Formation. Arterioscler Thromb Vasc Biol. Article In Press
Maddaluno M, Grassia G, Di Lauro MV, Parisi A, Maione F, Cicala C, De Filippis D, Iuvone T,
Guglielmotti A, Maffia P, Mascolo N, Ialenti A. Bindarit inhibits human coronary artery smooth muscle
cell proliferation, migration and phenotypic switching. PLoS One. 2012;7:e47464. Epub 2012
Macritchie N, Grassia G, Sabir SR, Maddaluno M, Welsh P, Sattar N, Ialenti A, Kurowska-Stolarska
M, McInnes IB, Brewer JM, Garside P, Maffia P. Plasmacytoid Dendritic Cells Play a Key Role in
Promoting Atherosclerosis in Apolipoprotein E-Deficient Mice. Arterioscler Thromb Vasc Biol. 2012
32:2569-79
Ialenti A., Grassia G., Gordon P., Maddaluno M., Di Lauro M.V.,Baker A.H., Guglielmotti A., Colombo
A., Biondi G., Kennedy S., Maffia P. Inhibition of In-Stent Stenosis by Oral Administration of Bindarit in
Porcine Coronary Arteries. Arterioscler Thromb Vasc Biol. 2011 31:2448-54. ISSN: 1079-5642
Maddaluno M., Di Lauro M.V., Di Pascale A., Santamaria R., Guglielmotti A., Grassia G. and Ialenti A.
Monocyte chemotactic protein-3 induces human coronary smooth muscle cell proliferation.
Atherosclerosis 2011. 217:113-9. ISSN: 1879-1484
© European Union, 2002-2012 | http://europass.cedefop.europa.eu
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Curriculum Vitae
Marcella Maddaluno
Grassia G., Maddaluno M., Musilli C., De Stefano D., Carnuccio R., Di Lauro M.V., Parratt C.A.,
Kennedy S., Di Meglio P., Ianaro A., Maffia P., Parenti A. and Ialenti A. The IκB Kinase Inhibitor,
NEMO-binding Domain Peptide, for Inhibition of Balloon Injury-induced Neointimal Formation.
Arteriosclerosis, Thrombosis, and Vascular Biology. 2010. 30:2458-66. ISSN: 1079-5642
Grassia G, Maddaluno M, Guglielmotti A, Mangano G, Biondi G, Maffia P and Ialenti A. The antiinflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidemic mice.
Cardiovascular Research. 2009. 84, 485–493. ISSN: 0008-6363
Conference Proceedings
Xiao Q; Zhang F; Grassia G; Hu Y; Zhang Z; Xing Q; Yin X; Maddaluno M; Drung B; Schmidt B;
Maffia P; Ialenti A; Mayr M; Xu Q; Ye S. Matrix Metalloproteinase-8 Promotes Vascular Smooth
Muscle Cell Proliferation and Neointima Formation. Circulation. 2012; 126: A10648.
Maddaluno M., Di Lauro M.V., Di Pascale A., Santamaria R.,Guglielmotti A., Grassia G., Ialenti A.
Induction of human coronary smooth muscle cell proliferation by monocyte chemotactic protein-3 35°
Congresso nazionale della Società italiana di Farmacologia. Bologna, 14 – 17 September 2011
Di Lauro M.V. , Grassia G., Maddaluno M., Musilli C., De Stefano D., Carnuccio R., Ianaro A., Maffia P.,
Parenti A., Ialenti A. Neointimal hyperplasia is inhibited by the IκB-kinase inhibitor, NEMO-binding
Domain Peptide in apoE-/- mice 35° Congresso nazionale della Società italiana di Farmacologia.
Bologna, 14 – 17 September 2011
Grassia G., Guglielmotti A., Maddaluno M., Di Lauro M.V., Gordon P., Maffia P., Kennedy S., Ialenti
A.Bindarit reduces in-stent restenosis in porcine coronary arteries via the inhibition of MCP-1
production. 35° Congresso nazionale della Società italiana di Farmacologia. Bologna, 14 – 17
September 2011
Maddaluno M. Induction of human coronary smooth muscle cell proliferation by Monocyte chemotactic
protein-3 XV National Seminar of PhD Students in Pharmacology and Related Sciences. September
2011
Colombo A., Guglielmotti A., Grassia G., Gordon P., Maddaluno M., Di Lauro M.V., Ble A., Ialenti A.,
Maffia P., Kennedy S. Bindarit, an inhibitor of monocyte chemotactic proteins (MCPs) production,
reduces restenosis in a porcine coronary stent model. European Hearth Journal. 2010; 31:0195-668X
Guglielmotti A., Grassia G., Gordon P, Maddaluno M., Di Lauro M.V., Biondi G., Colombo A., Ialenti A.,
Maffia P., Kennedy S. Bindarit, an Inhibitor of Monocyte Chemoattractant Proteins (MCPs) Production,
Reduces in-Stent Restenosis in Porcine Coronary Arteries. Circulation. 2010;122:A11429
Di Lauro M. V., Maddaluno M., Di Pascale A.,. Guglielmotti A, Grassia G., Ialenti A.. La proteina
chemio tattica per i monociti-3 (MCP-3) induce la proliferazione delle cellule muscolari lisce di arteria
coronarica umana. Giornate Scientifiche del Polo delle Scienze e delle Tecnologie per la Vita.
Università degli Studi di Napoli “Federico II”, 2010
M. Maddaluno, G. Grassia, C. Musilli, D. De Stefano, M.V. Di Lauro, P. Di Meglio, R. Carnuccio, S.
Kennedy, C. Parrat, A. Ianaro, P. Maffia, A. Parenti, A. Ialenti. Il peptide NBD, inibitore selettivo di NFκB, riduce l’iperplasia neointimale in seguito a danno vascolare. VII Convegno Monotematico della
Società Italiana di Farmacologia, Prospettive e innovazione nella ricerca cardiovascolare: dalla ricerca
di base a quella clinica. Napoli, 6-7 October 2010
Maddaluno M., Grassia G., De Stefano D., Carnuccio R., De Simone L., Neri E., Grieco P., Ialenti A. GNBD, a novel cell-permeable peptide, inhibits NF-κB activation. 34° Congresso nazionale della
Società italiana di Farmacologia. Rimini 14-17/10/2009.
Ialenti A., Maddaluno M., Grassia G., Mangano G.,Bartella C., Neri E., De Simone L., Maffia P.,
Guglielmotti. Bindarit, an inhibitor of monocyte chemoattractant protein-1 synthesis, reduces neointima
hyperplasia both in rats and in hypercolesterolemic mice. 34° Congresso nazionale della Società
italiana di Farmacologia. Rimini 14-17/10/2009.
Grassia G., Maddaluno M., Maffia P., Musilli C., Parenti A., De Stefano D., Carnuccio R., Ianaro A.,
Grieco P., Ialenti. NBD Peptide, a selectine inhibitor of NF-κB, reduces neointimal formation in a rat
model of vascular injury. 34° Congresso nazionale della Società italiana di Farmacologia. Rimini 1417/10/2009.
© European Union, 2002-2012 | http://europass.cedefop.europa.eu
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Curriculum Vitae
Marcella Maddaluno
Guglielmotti A., Grassia G., Maddaluno M., Maffia P., Mangano G., Bartella C., Ialenti A. Bindarit
Inhibits Neointimal Hyperplasia, an Effect Associated with Inhibition of Monocyte Chemoattractant
Protein-1 Synthesis. Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference 2009.
Published in Arteriosclerosis, Thrombosis, and Vascular Biology. 2009. 29 (7): E96-E96.
Maffia P., Grassia G., Maddaluno M., De Stefano D., Carnuccio R., Ianaro A., Grieco P., Musilli C.,
Parenti A., Armando Ialenti. The I kappa B Kinase Inhibitor, NEMO-Binding Domain Peptide, Inhibits
Rat Balloon Injury-Induced Neointimal Formation. Arteriosclerosis, Thrombosis, and Vascular Biology
Annual Conference 2009. Published in Arteriosclerosis, Thrombosis, and Vascular Biology. 2009. 29
(7): E99-E99
Gordon P., Grassia G., Guglielmotti A., Maddaluno M., Di Lauro M.V., Pierucci D., Blè A., Ialenti A.,
Maffia P., Kennedy S. Effects of Bindarit in a Porcine Coronary Artery Model of Vascular Restenosis.
Scottish Cardiovascular Forum, University of Glasgow, UK
Maddaluno M., Grassia G., Maffia P., Musilli C., Parenti A., Ialenti A. Il peptide NBD, inibitore selettivo
di NF-κB, riduce la formazione di neointima in un modello di danno vascolare nel ratto. Giornate
Scientifiche del Polo delle Scienze e delle Tecnologie per la Vita. Università degli Studi di Napoli
“Federico II”, 2008.
Grassia G., Maddaluno M., Guglielmotti A., Mangano G., Bartella C., Maffia P., Ialenti A. Bindarit, an
inhibitor of MCP-1, attenuates neointimal hyperplasia after balloon injury in rats. XV Congresso
Nazionale della Società Italiana di Ricerche Cardiovascolari (SIRC). Imola, 9-11 October 2008.
Maddaluno M., Grassia G., Di Meglio P., Tersigni M., Berrino L., Garside P., Ianaro A, Ialenti A, Maffia
P. La neutralizzazione della IL-18 inibisce la formazione di neointima in un modello di danno vascolare
nel ratto. Giornate Scientifiche del Polo delle Scienze e delle Tecnologie per la Vita. Università degli
Studi di Napoli “Federico II”, 2006.
Membership of society
Professional Accreditations
Italian Society of Pharmacology (SIF)
Personal licence" (PIL) for surgery and handling of small mammals, according to the Animals
(Scientific Procedure) Act 1986. University of Glasgow, UK, 14/04/11.
Accreditation to practice the biology profession. University of Naples, Federico II, Italy. 2008
I authorize the use of my personal information, according to the Italian Law 30 june 2003 n. 196, Code
for the protection of personal information (Rights of access to personal information and other rights).
Signature
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