Low Pathogenic Avian Influenza H5 (LPAI) in Italy SCoFCAH Bruxelles, 6-7 February 2014 Epidemiological Situation 2013 In 2013 nine H5 LPAI outbreaks were identified The outbreaks mainly involved commercial and rural flocks located in: Lombardia Veneto Emilia Romagna Campania The single industrial holding affected was located in Emilia Romagna 2013 H5 LPAI outbreaks – Summary ADNS Conf. Date Depop. Date Est. Date Region Province Type 13/0001 19.02.2013 25.02.2013 11.04.2013 Emilia Romagna Modena Rural 13/0002 10.10.2013 14.10.2013 08.11.2013 Lombardia Brescia Commercial 13/0003 11.10.2013 17.10.2013 28.11.2013 Campania Salerno Commercial 13/0004 21.11.2013 09.12.2013 10.01.2014 Campania Avellino Rural 13/0005 03.12.2013 12.12.2013 * 12.12.2013 Emilia Romagna Forlì Cesena Industrial 13/0006 03.12.2013 05.12.2013 02.01.2014 Campania Napoli Rural 13/0007 03.12.2012 05.12.2013 12.12.2013 Emilia Romagna Modena Rural 13/0008 24.12.2013 28.12.2013 05.01.2014 Veneto Treviso Commercial 13/0009 27.12.2013 27.12.2013 27.12.2013 Lombardia Mantova Rural * The farm was empty at confirmation, the date refers to the disinfection activities H5 LPAI outbreak – Friuli Venezia Giulia ADNS Number 14/0001 On 28 Jan 2014 the National Reference Laboratory confirmed a virological positivity for AI virus for LPAI virus H5N1 subtype in a grower/commercial farm in Udine province Control measures: Ban of movement of animals from the infected farm Depopulation On 2 Feb 2014 the depopulation procedures ended Preliminary cleaning activities has been started on 4 Feb 2014 H5 LPAI outbreak – Friuli Venezia Giulia Grower/commercial farm with 1005 birds (see table) All the birds present at requisition were culled Epidemiological investigations are ongoing Species Broilers Laying hens Ducks Number 350 26 325 Guinea Fowls 60 Pheasans 88 Qualis 156 Total 1005 H5 LPAI outbreak – Friuli Venezia Giulia A/MigratoryDuck/Jiang Xi/13487/2005 H5N3 • Ducks tested positive to PCR, although serological tests before culling were negative • Of the other species, only Guinea fowls resulted (weekly) positive to serological tests made before culling A/garganey/SanJiang/160/2006 H5N2 A/duck/Mongolia/500/01 H5N3 A/duck/Primorie/2621/01 H5N2 82 A/duck/Primorie/2633/01 H5N3 88 A/garganey/Altai/1213/2007 H5N2 gadwall/Altai/1202/2007 H5N2 78 80 A/mallard/Crimea/224/2008 H5N2 77 A/mallard/Crimea/245/2008 H5N2 A/mallard/Sweden/64/02 H5N2 A/avian/Mali/669/2006 HA A/mallard/Switzerland/W V1070754/2007 A/mallard/Sweden/79/02 H5N9 A/chicken/France/03426a/03 H5N2 A/mallard/Italy/208/2000 H5N3 A/turkey/Italy/1258/2005 H5N2 89 A/turkey/Italy/1325/2005 H5N2 A/mallard/Italy/37/2002 H5N3 A/mallard/Italy/36/2002 H5N3 • Preliminary phylogenetical analyses: A/chicken/Italy/13VIR-6051-2/2013 A/greatblackbackedgull/Iceland/111.(H5N2 A/avian/Italy/7950/2010 H5 A/duck/Tulcea/RO-AI-LPAI/2009 H5N3 A/duck/Italy/11rs1179/2011 – High similarity with the HA gene of the virus identified in the previous outbreaks (2013) A/mallard/Italy/3401/2005 H5N1 A/duck/Italy/13VIR-6078-1/2013 A/duck/Italy/13VIR-6078-3/2013 A/duck/Italy/13VIR7232-1/2013 87 A/duck/Italy/13VIR-7584/2013 A/duck/Italy/13VIR7207-2/2013 A/duck/Italy/13VIR7207-10/2013 A/duck/Italy/13VIR7232-2/2013 A/duck/Italy/14VIR367/2014 A/little grebe/Xianghai/429/2011(H5N2) H5 LPAI outbreak – Friuli Venezia Giulia 99 A/ruddy shelduck/Mongolia/1189/2010 H7N1 99 92 80 A/ruddy shelduck/Mongolia/1209/2010 H7N1 A/mallard /Mongolia/1551/2010 H3N1 A/ruddy shelduck/Mongolia/921C2/2009 ... A/lesser whistling-duck/Thailand/CU-W ... 87 A/aquatic bird/India/NIV-17095/2007 H... A/duck/Zhejiang/2245/2011 H5N1 99 A/mallard/Sweden/105522/2009 H10N1 100 A/mallard/Sweden/104803/2009 H1N1 A/duck/Italy/14VIR-367/2014 H5N1 99 A/chicken/Pakistan/NARC-16945/2010 H3N1 84 98 A/common goldeneye/Mongolia/1216/2010... 98 A/tufted duck/Mongolia/1409/2010 H1N1 91 A/European teal/Novosibirsk/261/2011 ... 100 • The NA gene is related with low pathogenicity viruses circulating in wild birds in Europe and Asia, and in particular it showed high similarity with the NA from H1N1 viruses isolated from ducks in Mongolia A/European teal/Novosibirsk/239/2011 ... A/duck/Mongolia/47/2001 H7N1 • The virus likely originated from reassortment A/duck/Suphanburi/AI157/2005 H6N1 99 99 A/duck/Mongolia/253/2003 H1N1 75 A/duck/Eastern China/253/2003 H3N1 A/wild duck/Germany/W V30/06 H1N1 75 A/teal/Germany/W v632/2005 H5N1 100 99 A/Goose/Italy/6117/2004 H1N1 A/goose/Italy/296426/2003 H1N1 A/mallard/Italy/3401/2005 H5N1 99 95 A/duck/Italy/281904/2006 H1N1 A/duck/Italy/69238/2007 H1N1 • No deletions at stalk deletion level were detected (no adaption to domestic birds) • No additional glycosilation sites (no mutation into Highly Pathogenic strains) Thanks for your attention
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