ᮾᲷ ᐇ㦂⏕≀ඹྠ⏝㒊㛛 −3− ᐇ㦂⏕≀ඹྠ⏝㒊㛛 ᙜ㒊㛛ࡣࠊ࣐࢘ࢫࠊࣛࢵࢺࠊ࢘ࢧࢠࠊࣔࣝࣔࢵࢺࡢ့ஙື≀ຍ࠼ࠊ࢟ࣥ࢝ࢳࣙ࢘➼ ࡢ㫽㢮ࠊ࣓ࢲ࢝➼ࡢ㨶㢮ࠊ࢝ࡸࢨࣜ࢞ࢽࠊࣟࣈࢫࢱ࣮࠸ࡗࡓῐỈࡸᾏ⏘ࡢ↓⬨᳝ື ≀ࠊࢥ࢜ࣟࢠࡸࢦ࢟ࣈࣜ➼ࡢ᪻ࠊࡲࡓࢩࣟࢼࢬࢼ➼ࡢᐇ㦂᳜≀ࡽ㔝እ᥇ྲྀࡋ࡚ࡁ ࡓ᳜≀ࠊࡉࡽᶞᮌ⮳ࡿࡲ࡛ࠊᵝࠎ࡞⏕≀✀ࢆ㣫⫱࣭᱂ᇵ࡛ࡁࡿࡼ࠺ᩚഛࢆ⾜ࡗ࡚࠸ ࡿඹྠ⏝タ࡛ࡍࠋ㏆ᖺࡣࠊ࣐࢘ࢫࠊࣛࢵࢺࡢࡳ࡞ࡽࡎࠊ࣓ࢲ࢝ࡸࢥ࢜ࣟࢠ࠾࠸࡚ ࡶ㑇ఏᏊᨵኚື≀ࡀ㣫㣴ࡉࢀ࡚࠾ࡾࠊἲ‽ᣐࡋࡓ㣫⫱タഛࡢᩚഛࡶᚰࡀࡅ࡚࠾ࡾࡲ ࡍࠋࡇࢀࡽࡢඹྠ⏝ຍ࠼ࠊ࣐࢘ࢫࣛࢵࢺࡢ㏆⣔ࡢ⥔ᣢᴗࡶ⾜ࡗ࡚࠾ࡾࡲࡍࠋ ᮏタࡢ❹ᕤࡣ 56 ᖺ࡛࠶ࡾࠊࡍ࡛⠏ 35 ᖺࢆ⤒㐣ࡋ࡚࠾ࡾࡲࡍࠋᘓ≀ࡸᖏタ ഛࡢ⪁ᮙࡀ㐍ࡳࠊಟ⌮ࡍࡁ㡯ࡀቑ࠼࡚ࡁ࡚࠾ࡾࡲࡍࠋᖺᗘࠊᖾ࠸ࡶ㛵ಀ㒊 ⨫ࡢࡈ༠ຊࡶ࠶ࡾࠊ⤥Ỉ⟶ࢆタ⨨ࡍࡿࡓࡵࡢண⟬❧࡚ࢆࡋ࡚࠸ࡓࡔࡁࠊᖜᨵಟࡍࡿ ࡇࡀ࡛ࡁࡲࡋࡓࠋࡇࡢຠᯝࡣ㠀ᖖࡁࡃࠊ⤥Ỉ⟶ࡢᨾࡣᖜῶࡾࠊࡑࢀせࡍ ࡿಟ⧋㈝ࢆ๐ῶࡍࡿࡇࡀ࡛ࡁࡲࡋࡓࠋࡇࢀࡲ࡛ࡃᡭࢆࡅࡿࡇࡀ࡛ࡁ࡞ࡗࡓ✵ ㄪᩚഛẼࡸ Ỉ⟶ࠊࡑࡢタഛࡢ᭦᪂ࡶࠊ⪃៖࡛ࡁࡿࡼ࠺࡞ࡾࡲࡋࡓࠋᚋࡶ ◊✲⎔ቃࡢྥୖ࣭⥔ᣢࢆ┠ᣦࡋ࡚ࠊ◊✲࣭ᐇ㦂ࡢሙࢆᥦ౪ࡋ࡚࠸ࡃᡤᏑ࡛ࡍࠋ ᖹᡂ㸰㸵ᖺᗘ ᐇ㦂⏕≀ඹྠ⏝㒊㛛 ⏝⪅≧ἣ 㒊ᒁ ࢸ࣮࣐ᩘ Ꮫ㝔ᩥᏛ◊✲⛉ 㸰 Ꮫ㝔་Ꮫ◊✲⛉ 㸰 Ꮫ㝔ᆅ⌫⎔ቃ⛉Ꮫ◊✲㝔 㸳 Ꮫ㝔⌮Ꮫ◊✲㝔 㸰㸮 Ꮫ㝔㎰Ꮫ◊✲㝔 㸱 Ꮫ㝔ඛ➃⏕⛉Ꮫ◊✲㝔 㸯 Ꮫ㝔ᕤᏛ◊✲㝔 㸰 ప ⛉Ꮫ◊✲ᡤ 㸯 㟁Ꮚ⛉Ꮫ◊✲ᡤ 㸯 ᪉⏕≀ᅪࣇ࣮ࣝࢻ⛉Ꮫࢭࣥࢱ࣮ 㸯 ⥲ྜ༤≀㤋 㸰 ᡂ◊✲ᶵᵓ 㸯 ィ 㸲㸯 −4− 䚷䚷ᖹᡂ㻞㻣ᖺᗘ⏝⪅䛾ෆヂ ᪉䢈䡤䡬䢕䢀䢚㻘㻌㻝 㟁Ꮚ㻘㻌㻝 ᡂ㻘㻌㻝 ప 㻘㻌㻝 ㉸⣧Ỉ㻘㻞 ඛ➃⏕㻘㻌㻝 ့ங㢮䞉 㫽㢮㻘㻝㻝 ᾏỈ㻘㻤 ᩥᏛ㻘㻌㻝 ༤≀㤋㻘㻌㻞 ⌮Ꮫ㻘㻌㻝㻥 ᕤᏛ㻘㻌㻞 ᪻㻘㻢 ᆅ⎔㻘㻌㻞 ་Ꮫ㻘㻌㻞 ⣧Ỉ㻘㻝㻝 ᳜≀㻘㻢 Ỉ⏕ື≀㻘㻝 ㎰Ꮫ㻘㻌㻟 ᢅ䛳䛶䛔䜛⏕≀ཬ䜃Ỉ➼⏝䛾⏦ㄳᩘ ⏝⏦ㄳ⪅ᡤᒓ㒊ᒁ 㻠㻞 㻟㻢 㻴㻞㻜 㻟㻝 㻴㻞㻝 㻠㻝 㻟㻡 㻴㻞㻞 㻴㻞㻟 㻴㻞㻠 㻟㻤 㻴㻞㻡 㻠㻝 㻟㻢 㻴㻞㻢 䠤㻞㻣 㻠㻟 㻠㻝 㻴㻞㻢 䠤㻞㻣 ⏝⏦ㄳᩘ᥎⛣ 㻟㻣 㻴㻞㻜 㻠㻟 㻠㻞 㻠㻜 㻴㻞㻟 㻴㻞㻠 㻴㻞㻡 㻟㻤 㻟㻟 㻴㻞㻝 㻴㻞㻞 ◊✲䝔䞊䝬ᩘ᥎⛣ −5− 㻌 ᖹᡂ䠎䠓ᖺᗘ㻌 䝛䝈䝭౪⤥䝸䝇䝖㻌 㻌 Ꮫ㒊䞉タ㻌 ㎰Ꮫ㒊㻌 ㅮᗙ㻌 㣗ရᶵ⬟Ꮫ㻌 ྜィ 䝷䝑䝖㻌 㻢㻌 㻢㻌 䠄༉ᩘ䠅㻌 䝝䝮䝇䝍䞊㻌 㻜㻌 㻜㻌 䝬䜴䝇㻌 㻜㻌 㻜㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 ᖹᡂ䠎䠓ᖺᗘ㻌 ⣔⤫ู䝛䝈䝭౪⤥䝸䝇䝖㻌 㻌 䠄༉ᩘ䠅㻌 䝷䝑䝖㻌 䝬䜴䝇㻌 䠳䡅䡏䡐䡁䡎㻌 㻢㻌 ྜィ㻌 㻢㻌 㻌 䝝䝮䝇䝍䞊㻌 㻜㻌 ྜィ㻌 㻜㻌 㻌 㻜㻌 ྜィ㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 ᖹᡂ䠎䠓ᖺᗘ㻌 άືሗ࿌㻌 㻌 ฟ∧≀㻌 䞉 ᾏ㐨ᏛᏛ㝔⌮Ꮫ◊✲㝔㝃ᒓ䝀䝜䝮䝎䜲䝘䝭䜽䝇◊✲䝉䞁䝍䞊㻌 ᴫせ㻌 㻞㻜㻝㻡㻌 㻌 −6− 㻜㻌 ᖹᡂ㻞㻣ᖺᗘ㻌ᐇ㦂⏕≀ඹྠ⏝㒊㛛䚷ಖᏲႠ⧋䝸䝇䝖 ᖹᡂ㻞㻣ᖺ ᖹᡂ㻞㻤ᖺ 㻠᭶ ᐃᮇΎᤲ㻔ẖ᭶䠅 ⎔ቃ⾨⏕⟶⌮Ⅼ᳨䠄ẖ᭶䠅 ᶞᮌᅖ䛔እ䛧ᴗົ 㻡᭶ 㻞㝵ඹྠᐇ㦂ᐊᐊእᶵᇶ♏ ⋞㛵㏥ฟ⏝ᢲ㔱㏣ຍᕤ 㻝㝵ὙίᐊẼ䝞䝹䝤 㻞㝵㣫ᩱㄪᩚᐊ⤥Ỉῶᅽᘚ 㻢᭶ ⲡส䜚ᴗົ 㻣᭶ ⣧Ỉ䝍䞁䜽⏝᥇Ỉ䝁䝑䜽సᴗ ᾘẘჾᛶ⬟᳨ᰝᩚഛ䠄䜸䞊䝖䜽䝺䞊䝤䠅 㢼㝖ᐊ䜺䝷䝇ಟ⧋ᕤ 㻤᭶ ở≀ฎ⌮ᐊ䝗䜰䜺䝷䝇ಟ⧋ᕤ 㻞㝵᳜≀ᇵ㣴ᐊ䠄㻠䠅䠄㻡䠅෭ᶵಟ⌮ 㻝㻜᭶ ở≀ฎ⌮ᐊ䝗䜰⿵ಟᕤ 㻝㻝᭶ 㻝㝵Ὑί⁛⳦ᐊ䜸䞊䝖䜽䝺䞊䝤㻌䝗䜰䝟䝑䜻䞁ྲྀ᭰ᕤ ᐊᒇ᰿䜺䝷䝇ྲྀ᭰ᕤ 㻝㻞᭶ 㝖㞷ᶵⅬ᳨䞉ᩚഛ ᶞᮌᅖ䛔ᴗົ 㻝᭶ 㻝㝵Ὑί⁛⳦ᐊᡬ㻞䛛ᡤ⿵ಟᕤ 㻟᭶ 䛢䛳ṑ㢮✵ㄪ㻼㻭㻯㻙㻝㻘㻼㻭㻯㻙㻞㻌䜶䜰䝣䜱䝹䝍䞊ᕤ ᐊ䝇䜽䝸䞊䞁⿵ಟᕤ 㻞㝵ᐇ㦂ᐊ䠄㻡䠅䠄㻝㻜䠅䝍䜲䝮䝇䜲䝑䝏ྲྀ᭰ᕤ 㻞㝵㻾㻙㻝⣔⤫䜶䜰䝁䞁ᐊእᶵᛂᛴಟ⌮ −7− ᖹᡂ㻞㻣ᖺᗘ䚷䝀䝜䝮䝎䜲䝘䝭䜽䝇◊✲䝉䞁䝍䞊䚷⏝⪅◊✲ㄢ㢟 䠄ᐇ㦂⏕≀ඹྠ⏝㒊㛛䠅 ᡤᒓ 㒊㛛䞉ศ㔝➼ ⫋ Ặྡ 㻝 ᩥᏛ◊✲⛉ ே㛫䡸䡹䡿䢍⛉Ꮫᑓᨷ䞉ᚰ⌮䡸䡹䡿䢍⛉Ꮫㅮᗙ ᩍᤵ ⏣㻌༤⨾ 㻞 ་Ꮫ◊✲⛉ ་Ꮫᑓᨷ䞉⏕⌮Ꮫㅮᗙ ຓᩍ 㻟 ་Ꮫ◊✲⛉ ་Ꮫᑓᨷ䞉እ⛉Ꮫㅮᗙ ຓᩍ ᒾぢ㻌ᇶ ṇᖖ⾑⢾⎔ቃୗ䛷䛾⢾ᒀ㻗㻮㻝㻟㻦㻲㻟㻥ᛶ⭈䛾ྍ㏫ᛶ䛸䛭䛾ኚ䛻ᑐ䛩䜛ච ᢚไ䛾ᙳ㡪䛾◊✲ 㻠 ᆅ⌫⎔ቃ⛉Ꮫ ◊✲㝔 ⤫ྜ⎔ቃ⛉Ꮫ䞉⮬↛⎔ቃಖ ᩍᤵ 㟢ᓮ㻌ྐᮁ ᳜≀⏕⫱⎔ቃ䛻ᛂ䛨䛯㠀◚ቯⓗ䝞䜲䜸䝬䝇 ᐃ᪉ἲ䛾᳨ウ ⅆᒣ㑄⛣䛻䛚䛡䜛ᇙᅵ✀Ꮚ⤌ᡂኚ 䝸䝍䞊✚㔞䛜᳜≀䛾Ⓨⱆ䞉ᡂ㛗䛻䛘䜛ᙳ㡪 䜸䜸䜰䝽䝎䝏䝋䜴䛾Ⓨⱆ䞉ᡂ㛗䛻ᅵተ䛜䛘䜛ᙳ㡪 㻡 ᆅ⌫⎔ቃ⛉Ꮫ ◊✲㝔 ⤫ྜ◊✲⛉Ꮫ䞉⎔ቃ㐺ᛂ⛉Ꮫ ᩍᤵ Ἀ㔝㻌㱟ᩥ ᾏ⏘⸴㢮䛾ḟ௦ㅰ⏘≀䛻㛵䛩䜛◊✲ 㻢 ⌮Ꮫ◊✲㝔 ≀⌮Ꮫ䞉㔞Ꮚ≀⌮Ꮫ ᩍᤵ ᯇỌ㻌ᝅ᫂ ᭷ᶵᑟయ䛻䛚䛡䜛≀ᛶ ᐃ 㻣 ⌮Ꮫ◊✲㝔 ≀⌮Ꮫ䞉㟁Ꮚ≀ᛶ≀⌮Ꮫ ᩍᤵ Ἑᮏ㻌ྖ ヨᩱྜᡂ 㻤 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉ᙧែᶵ⬟Ꮫ ᩍᤵ ᒣཱྀ㻌῟ 㧗➼᳜≀䛾㑇ఏᏊⓎ⌧ไᚚᶵᵓ 㻥 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉ᙧែᶵ⬟Ꮫ ᩍᤵ 㧗⏣㻌Ὀᘯ ዲ෭⳦䛜ᣢ䛴ప 㐺ᛂᆺ㓝⣲䛻㛵䛩䜛◊✲ 㻝㻜 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉ᙧែᶵ⬟Ꮫ ᩍᤵ ⥥ᘬ㻌㞞 䜸䞊䜻䝅䞁స⏝ᶵᵓ䛾ศᏊⓗ◊✲ 㻝㻝 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉ᙧែᶵ⬟Ꮫ ຓᩍ ఀ⸨㻌⚽⮧ ⎔ቃኚື䛻䛸䜒䛺䛖㌿⛣ᅉᏊ䛸ᐟ䛾䝀䝜䝮ᛂ⟅ 㻝㻞 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉⾜ື⚄⤒⏕≀Ꮫ ᩍᤵ ᯇᓥ㻌ಇஓ 䝙䝽䝖䝸㞮䠄䝠䝶䝁䠅䛾ㄆ▱䛸ពᛮỴᐃ䛻㛵䛩䜛ᐇ㦂ⓗ◊✲ 㻝㻟 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉⾜ື⚄⤒⏕≀Ꮫ ᩍᤵ ỈἼ㻌ㄔ 㻝㻠 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉⾜ື⚄⤒⏕≀Ꮫ ᩍᤵ ᑠᕝ㻌ᏹே 䝣䝍䝩䝅䝁䜸䝻䜼䛾⚄⤒⾜ືᏛⓗ◊✲ 㻝㻡 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉⾜ື⚄⤒⏕≀Ꮫ ᩍᤵ ⏣㻌୍༤ ᪂䛯䛺ែ䝰䝕䝹ື≀䛾సฟ䛸ཎᅉ㑇ఏᏊ䛾ྠᐃ 㻝㻢 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉⾜ື⚄⤒⏕≀Ꮫ ᩍᤵ ከ㻌ᏹ 㬆⚺㢮䜢⏝䛔䛯ⓎኌᏛ⩦䞉⏕ᡂ䛸䛭䛾⬻ෆศᏊᶵᵓ 㻝㻣 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉⏕ṪⓎ⏕⏕≀Ꮫ ᩍᤵ ᒣୗ㻌ṇව ⬨᳝ື≀䛻䛚䛡䜛⏕Ṫ⣽⬊ᙧᡂ䛾ไᚚᶵᵓ 㻝㻤 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉⏕ṪⓎ⏕⏕≀Ꮫ ≉௵ᩍᤵ ΎỈ㻌㝯 㻝㻥 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉⏕ṪⓎ⏕⏕≀Ꮫ ≉௵ᩍᤵ 㧗ᶫ㻌Ꮥ⾜ 㻞㻜 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉⏕ṪⓎ⏕⏕≀Ꮫ ᩍᤵ ᮌᮧ㻌ᩔ 㻞㻝 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉⏕ṪⓎ⏕⏕≀Ꮫ ᩍᤵ ᑠ㇂㻌ஓ 㻞㻞 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉ከᵝᛶ⏕≀Ꮫ ᩍᤵ ᯳ཎ㻌ᏹ 㻞㻟 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉ከᵝᛶ⏕≀Ꮫ ᩍᤵ ᑠட㻌୍ᘯ 㻞㻠 ⌮Ꮫ◊✲㝔 ⏕≀⛉Ꮫ䞉ከᵝᛶ⏕≀Ꮫ ຓᩍ ຍ⸨㻌ᚭ 㻞㻡 ㎰Ꮫ◊✲㝔 ᇶ┙◊✲䞉⏕≀㈨※⛉Ꮫ ᩍᤵ ⛅ඖ㻌ಙ୍ 䝃䝑䝫䝻䝣䜻䝞䝑䝍䛾㓄അ⾜ື䛸⏕Ṫ㝸㞳ᶵᵓ䛻㛵䛩䜛◊✲ 㻞㻢 ㎰Ꮫ◊✲㝔 ᇶ┙◊✲䞉ᛂ⏝⏕⛉Ꮫ ຓᩍ 㧗㔝㻌㡰ᖹ ᳜≀䛻䛚䛡䜛㌿ᚋไᚚᶵᵓ䛾◊✲ 㻞㻣 ㎰Ꮫ◊✲㝔 ᇶ┙◊✲䞉␆⏘⛉Ꮫ ᩍᤵ ᕝཎ㻌Ꮫ ඛ➃⼥ྜ⛉Ꮫ◊✲䞉⣽⬊䝎䜲䝘䝭䜽䝇⛉Ꮫ ᩍᤵ ᕝ➃㻌㔜 ඛ➃⏕⛉Ꮫ 㻞㻤 ◊✲㝔 ◊✲ㄢ㢟 ࿘⏘ᮇ䛾⏥≧⭢䝩䝹䝰䞁㜼ᐖ䛻䜘䜛Ⓨ㐩⚄⤒ẘᛶᏛⓗᙳ㡪䛾◊✲ ஙඣᮇ䛻䛚䛡䜛ẕᏊศ㞳䛜ᚰ⌮♫ⓗⓎ㐩䛻ཬ䜌䛩ᙳ㡪䛾◊✲ ᒣ㔝㎶㻌㈗ಙ ⚄⤒⣔䛻䛚䛡䜛ሗ䜻䝱䝸䜰䜢᫂䜙䛛䛻䛩䜛 㻞㻥 ᕤᏛ◊✲㝔 ᛂ⏝≀⌮Ꮫ䞉㔞Ꮚ≀ᛶᕤᏛ ᩍᤵ ⏣㻌⪽ 㻟㻜 ᕤᏛ◊✲㝔 䡰䢄䢕䡳䢚䡬⎔ቃ䡸䡹䡿䢍䞉ᛂ⏝䡰䢄䢕䡳䢚䡬䡸䡹䡿䢍 ᩍᤵ ㏆ஂ㻌Ṋ⨾ 㻟㻝 ప ⛉Ꮫ◊✲ᡤ ⏕≀⎔ቃ䞉⏕≀㐺ᛂ ຓᩍ ఀ⸨㻌ᑑ 㻟㻞 㟁Ꮚ⛉Ꮫ◊✲ᡤ ⏕⛉Ꮫ◊✲䞉」㞧⣔ᩘ⌮◊✲ ᩍᤵ 㟷㻌ோᚿ ᪉⏕≀ᅪ䝣䜱䞊 㻟㻟 䝹䝗⛉Ꮫ䝉䞁䝍䞊 ⏕≀ከᵝᛶ㡿ᇦ䞉ᾏ⏘⸴㢮㐺ᛂᶵ⬟ ᩍᤵ ᪻䛾Ꮫ⩦䛾⚄⤒ᶵᵓ ᪻䛾ໝ䛔ཷᐜ䛚䜘䜃ໝ䛔Ꮫ⩦䛾⚄⤒ᶵᵓ䛾ゎ᫂ 䜲䝖䝭䝭䝈⣽⬊⣔㆕䛾ゎᯒ ⬨᳝ື≀䛾⏕Ṫᶵ⬟䛻㛵䛩䜛◊✲ ့ங㢮䛾⏕Ṫ䛻䛛䛛䜟䜛䝀䝜䝮ᶵ⬟䛻㛵䛩䜛◊✲ ༸ẕ⣽⬊ᙧᡂ䛸ึᮇⓎ⏕䛾ศᏊᶵᵓゎᯒ ᾏ⏘↓⬨᳝ື≀䛾⣔⤫ศ㢮Ꮫⓗ◊✲ ⸴㢮䛾⣔⤫㐍Ꮫ 䝅䝵䜴䝆䝵䜴䝞䜶䛾⣔⤫Ꮫⓗ◊✲ 䝬䜴䝇⬇యእ᧯స䛻䜘䜛ಶయⓎ⏕䛻㛵䛩䜛◊✲ ື≀⤌⧊䛾ᵓ⠏ᶵᵓ䛾ゎ᫂ పḟඖᑟయ䛾㟁Ꮚ≧ែ䛾◊✲ ⇞ᩱ㟁ụෆỈศᣲື䛚䜘䜃䚸⤖⌧㇟䛾ྍどほᐹ ගྜᡂ㓝⣲Ⓨ⏕⣔䛾ゎ᫂ 䜽䝻䝁䜸䝻䜼䛻䛚䛡䜛㐺ᛂ⾜ື䛾ᐇ㛫ᛶ䜢ไᚚ䛩䜛⚄⤒ᶵᵓ䛾◊✲ ᅄ䝒㻌 䝁䞁䝤㢮䛾ᇵ㣴◊✲ 㻟㻠 ⥲ྜ༤≀㤋 ◊✲㒊䞉㈨ᩱᇶ♏◊✲⣔ ᩍᤵ 㧗ᶫ㻌ⱥᶞ ᐇ㦂⏝㔝⏕᳜≀䛾᱂ᇵ 㻟㻡 ⥲ྜ༤≀㤋 ◊✲㒊䞉㈨ᩱᇶ♏◊✲⣔ ㅮᖌ 㜿㒊㻌๛ྐ ⣚⸴䝋䝌ᒓ䛚䜘䜃㏆⦕ᒓ䛻㛵䛩䜛✀⏕≀Ꮫⓗ◊✲ ◊✲ேᮦ⫱ᡂ᥎㐍ᐊ ≉௵ຓᩍ ⏣୰㻌ᬸ᫂ 䝠䝯䜲䜹䛾⥅௦㣫⫱ᢏ⾡䛾㛤Ⓨ 㻟㻢 ᡂ◊✲ᶵᵓ −8− Мဇإԓᴾ Ꮫ㝔ᩥᏛ◊✲⛉ ே㛫ࢩࢫࢸ࣒⛉Ꮫᑓᨷ ᚰ⌮ࢩࢫࢸ࣒⛉Ꮫㅮᗙ ⏣ ༤⨾ ◊✲ࢸ࣮࣐ ᤵஙᮇࣛࢵࢺࡢ㉸㡢ἼⓎኌ㛵ࡍࡿ ◊✲ ᤵஙᮇࡢࣛࢵࢺࡣ㸪ẕぶࡽศ㞳ࡉࢀࡿ㉸㡢 ἼࢆⓎኌࡍࡿࠋࡇࡢ㉸㡢ἼⓎኌࡣ distress call㸦ⱞ ③ࢆッ࠼ࡿⓎኌ㸧ࡤࢀὀ┠ࡉࢀ࡚࠸ࡿࠋᅇ ࡣࡘࡢᐇ㦂ࢆ⾜࠸ࠊẕぶࡢ⮯࠸่⃭㸦ᐇ㦂㸯㸧 య పୗ㸦ᐇ㦂㸰㸧ࡀ㉸㡢ἼⓎኌཬࡰࡍᙳ㡪 ࡘ࠸࡚◊✲ࢆ⾜ࡗࡓࠋ ڦᐇ㦂㸯 ẕぶࡢ⮯࠸่⃭ࡀᤵஙᮇࣛࢵࢺࡢ㉸㡢 ἼⓎኌཬࡰࡍᙳ㡪 ⿕㦂యࡣᤵஙᮇࡢࣛࢵࢺ࡛ࠊ⏕ᚋ㸲ࠊ㸵ࠊ㸯㸮ࠊ 㸯㸱ࠊ㸯㸴ࠊ㸯㸷᪥┠㉸㡢ἼⓎኌࢆ ᐃࡋࡓࠋ ࣛࢵࢺࢆ୍༉ࡎࡘࠊᗋᩜࢆᩜ࠸ࡓࣉࣛࢫࢳࢵࢡ〇 ࢥࣥࢸࢼ࣮ධࢀࠊ㜵㡢⟽ෆ⨨࠸ࡓࠋᗋᩜࡣࠊ ձࡑࡢࣛࢵࢺࡀ㣫⫱ࡉࢀ࡚࠸ࡿࢣ࣮ࢪࡢᗋᩜ㸦⮬ ᗋᩜ㸧ࠊղู⭡ࡢࣛࢵࢺࡀ㣫⫱ࡉࢀ࡚࠸ࡿࢣ࣮ࢪࡢ ᗋᩜ㸦ᗋᩜ㸧 ࠊճᮍ⏝ࡢᗋᩜ㸦ᮍᗋᩜ㸧ࡢ㸱᮲ ௳ࢆタᐃࡋࡓࠋࣛࢵࢺࢆ㜵㡢⟽ෆ⨨ࡁࠊ㸳ศ㛫 ࡢ㥆ࡢᚋࠊ㸳ศ㛫Ⓨኌࢆ ᐃࡋࡓࠋࡑࡢ⤖ᯝࠊ Ⓨኌᅇᩘࡣ⮬ᗋᩜ᮲௳࡛ᗋᩜ᮲௳࣭ᮍᗋᩜ᮲௳ ࡼࡾῶᑡࡋࡓࠋ⮬ᗋᩜࡣ⮬ศࡢẕࣛࢵࢺࡢ⮯࠸ ࡀ╔ࡋ࡚࠸ࡿࡓࡵࠊẕᏊศ㞳ࡼࡗ࡚㉳ࡇࡿⱞ ③ࡸᏳࡀࡽࡆࡽࢀࡓࡓࡵ⪃࠼ࡽࢀࡿࠋⓎኌ ࿘Ἴᩘࡣࠊᮍᗋᩜ᮲௳࡛⮬ᗋᩜ᮲௳࣭ᗋᩜ᮲௳ ࡼࡾపୗࡋࡓࠋ㸯ᅇᙜࡾࡢⓎኌࡢ㛗ࡉࡣࠊᮍᗋᩜ ᮲௳࡛⮬ᗋᩜ᮲௳࣭ᗋᩜ᮲௳ࡼࡾ㛗ࡃ࡞ࡗࡓࠋ ௨ୖࡢࡇࡽࠊᤵஙᮇࡢࣛࢵࢺࡣᬑẁࡽႥ࠸ ࡛࠸ࡿẕࣛࢵࢺࡢ⮯࠸ࠊࡢẕࣛࢵࢺࡢ⮯࠸ࠊࣛ ࢵࢺ௨እࡢ⮯࠸ࢆ㆑ูࡍࡿࡇࡀฟ᮶ࡿ⪃࠼ࡽ ࢀࡿࠋ ڦᐇ㦂㸰 య పୗࡀᤵஙᮇࣛࢵࢺࡢ㉸㡢ἼⓎኌ ཬࡰࡍᙳ㡪 ⿕㦂యࡣᤵஙᮇࡢࣛࢵࢺ࡛ࠊ⏕ᚋ㸲ࠊ㸵ࠊ㸯 㸮ࠊ㸯㸱ࠊ㸯㸴ࠊ㸯㸷᪥┠㉸㡢ἼⓎኌࢆ ᐃࡋ ࡓࠋࣛࢵࢺࢆ୍༉ࡎࡘࣉࣛࢫࢳࢵࢡ〇ࢥࣥࢸࢼ࣮ ධࢀࠊẕᏊศ㞳┤ᚋࠊ㸯㛫ᚋࠊ㸰㛫ᚋࠊ㸱 㛫ᚋࡢ㸲ᅇ ᐃࡋࡓࠋࣛࢵࢺࡢධࡗࡓࢥࣥࢸࢼ ࣮ࢆ㜵㡢⟽ෆ⨨ࡁࠊ㸳ศ㛫ࡢ㥆ࡢᚋࠊ㸳ศ 㛫 ᐃࡋࡓࠋ┤⭠య ᐃࡣูࡢᤵஙᮇࡢࣛࢵࢺ ࢆ⏝ࡋࡓࠋࣛࢵࢺࢆ୍༉ࡎࡘࣉࣛࢫࢳࢵࢡ〇ࢥ ࣥࢸࢼ࣮ධࢀࠊ⏕ᚋ㸲ࠊ㸵ࠊ㸯㸮ࠊ㸯㸱ࠊ㸯㸴ࠊ 㸯㸷᪥┠㸱㛫ࡢẕᏊศ㞳ࢆ⾜ࡗࡓࠋ┤⭠య ࡣẕᏊศ㞳┤ᚋࠊ㸯㛫ᚋࠊ㸰㛫ᚋࠊ㸱㛫ᚋ ࡢ㸲ᅇ ᐃࡋࡓࠋࡑࡢ⤖ᯝࠊ㉸㡢ἼࡢⓎኌᅇᩘࡣ ⏕ᚋ㸵㹼㸯㸮᪥┠ࣆ࣮ࢡ㐩ࡋࠊࡑࡢᚋࡣᚎࠎ ῶᑡࡋࡓࠋࡲࡓ⏕ᚋ㸲㹼㸯㸮᪥┠ࡲ࡛ࡣࠊẕᏊ ศ㞳ࡢ㛫⤒㐣కࡗ࡚Ⓨኌᅇᩘࡀῶᑡࡋࡓࠋࡋ ࡋ⏕ᚋ㸯㸴㹼㸯㸷᪥┠࡞ࡿࠊ㏫ẕᏊศ㞳 㛫కࡗ࡚Ⓨኌᅇᩘࡀቑຍࡋࡓࠋ㸯ᅇᙜࡾࡢⓎ ኌࡢ㛗ࡉࡣࠊẕᏊศ㞳㛫కࡗ࡚㛗ࡃ࡞ࡗࡓࠋ ┤⭠య ࡣ⏕ᚋ㸲㹼㸯㸱᪥┠ࡲ࡛ࠊẕᏊศ㞳㛫 ࡶపୗࡋࡓࠋࡋࡋ⏕ᚋ㸯㸴㹼㸯㸷᪥┠ ࡞ࡿࠊ┤⭠య ࡣ㸱㛫ࡢẕᏊศ㞳ࢆ㏻ࡋ୍࡚ ᐃ࡛ࠊపୗࡍࡿࡇࡣ࡞ࡗࡓࠋ௨ୖࡢࡇࡽࠊ ᤵஙᮇࣛࢵࢺࡢ㉸㡢ἼⓎኌࡣࠊẕᏊศ㞳ࡼࡿ య పୗࡀ㔜せ࡞せᅉ࡞ࡗ࡚࠸ࡿ⪃࠼ࡽࢀࡓࠋ ⏕ᚋ㸯㸴᪥௨㝆࡞ࡿయẟそࢃࢀࠊ⮬ຊ࡛య ࢆ⥔ᣢ࡛ࡁࡿࡼ࠺࡞ࡿ⪃࠼ࡽࢀࡿࠋࡋࡋ ẕᏊศ㞳㛫ࡢ⤒㐣ࡶⓎኌᅇᩘࡣቑࡋࠊ ࡋࡶẕᏊศ㞳┤ᚋࡼࡾ㛗ࡉࡢ㛗࠸Ⓨኌࡀቑ࠼࡚ ࠸ࡃࠋ⏕ᚋ㸯㸴㹼㸯㸷᪥┠ࡢẕᏊศ㞳㸱㛫ᚋ ᐃࡉࢀࡓ㛗࠸Ⓨኌࡣࠊయ ௨እࡢせᅉࡼࡾ㉳ ࡗࡓ᥎ ࡉࢀࡿࠋ࠼ࡤࠊẕࣛࢵࢺࡀ࠸࡞࠸ࡇ ࡼࡿⱞ③ࡸᏳࠊ࠶ࡿ࠸ࡣ✵⭡ࡀ⪃࠼ࡽࢀࡿࠋ ࠙ㄽᩥⓎ⾲ࠚ Wada H. Thyroid hormone deficiency and development of ultrasonic vocalization responses in rat pups. Organohalogen Compounds, 77: 324-328, 2015. ࠙ⴭ ᭩ࠚ ⏣༤⨾㸬 ࣝࢥ࣮ࣝ⸆≀ࡢᙳ㡪㸪 㸫 㡫㸦ᴬཎὒ୍࣭⡿⏣ⱥႹ ⦅㸸Ⓨ㐩⛉Ꮫࣁ ࣥࢻࣈࢵࢡ➨ ᕳ⬻ࡢⓎ㐩⛉Ꮫ㸧 㸦᪂᭙♫㸪ᮾி㸧 㸬 ࠙ᏛⓎ⾲ࠚ Wada H. Perinatal hypothyroidism and ultrasonic vocalization in rat pups. International Neurotoxicology Association, Montreal, Canada, June 27-July 1, 2015. Wada H. Thyroid hormone deficiency and development of ultrasonic vocalization responses in rat pups. Dioxin 2015, San Paulo, Brazil, August 23-28, 2015. ⏣༤⨾㸬ࣛࢵࢺ࠾ࡅࡿ࿘⏘ᮇࡢ⏥≧⭢࣍ ࣝࣔࣥ㜼ᐖ㉸㡢ἼⓎኌࡢⓎ㐩㸬➨㸴ᅇ㹎㹁㹀ㅮ ₇㸪ᾏ㐨Ꮫ㸦ᮐᖠᕷ㸧㸪 Kawamura Y & Wada H. Developmental changes of isolation-induced ultrasonic vocalizations of rat pups: Analysis of call types.➨ ᅇື≀ᚰ⌮Ꮫ㸪 ᪥ᮏዪᏊᏛ㸦ᮾி㒔ᩥி༊㸧 㸪 Ἑᮧ㔛⤮࣭⏣༤⨾ஙඣᮇẕᏊศ㞳ࡀ ࣛࢵࢺࡢ㉸㡢ἼⓎኌ࠼ࡿᙳ㡪➨ ᅇ᪥ᮏ ᚰ ⌮ Ꮫ 㸪 ྡ ྂ ᒇ ᅜ 㝿 ㆟ ሙ 㸦 ྡ ྂ ᒇ ᕷ 㸧㸪 −9− Ꮫ㝔་Ꮫ◊✲⛉ ་Ꮫᑓᨷ ⏕⌮Ꮫㅮᗙ ᒣ㔝㎶ ㈗ಙ ⚄⤒⣔࡛ࢫࣃࢡิࡼࡾሗࡀ㐠ࡤࢀࡿࡀࠊ ࡢ⤫ィ㔞ࡀሗ࢟ࣕࣜ࡞ࡢゎ᫂ࡉࢀ࡚࠸࡞ ࠸ࠋ⚄⤒ᅇ㊰⌮ㄽࡼࢀࡤ⣲Ꮚࡢฟຊ㛵ᩘࡼࡾࠊ ⚄⤒ᅇ㊰ࣔࢹ࡛ࣝࡢሗ࢟ࣕࣜࡀỴࡲࡿࠋࢫࣃ ࢡࡣ⚄⤒⣽⬊ࡀ㐣Ώ≧ែ࠶ࡿࡁ⏕ࡌࠊࢫ ࣃࢡ⏕ᡂࡣ㐣ཤࡢ⚄⤒άື౫Ꮡࡍࡿ㸦Segundo et al.Neuroscience 1994, Yamanobe et al. Biosystems 1998㸧ࠋࡲࡓࠊ⚄⤒⣽⬊ࡣࠊᣑᩓ㐣⛬࡛㏆ఝࡉࢀࡿ ࢜ࣥࢳࣕࢿࣝࣀࢬࡔࡅ࡛࡞ࡃࠊࢩࢼࣉࢫᑠ⬊ ࡢ⮬Ⓨⓗᨺฟࡼࡿࢪࣕࣥࣉࣀࢬ࡞ࢆᣢࡘࠋ ࡇࡢ㐣Ώᛂ⟅ࣀࢬࡢᙳ㡪ࢆᫎࡋࡓฟຊ㛵ᩘ ࡢ≉ᛶࢆᐇ㦂ⓗồࡵࡿࡇࡀࠊሗ࢟ࣕࣜࢆ ゎ᫂ࡍࡿࡓࡵᚲせ࡛࠶ࡿ⪃࠼ࡽࢀࡿࠋᐇ㦂࡛ ⚄⤒⣽⬊ࡢฟຊ㛵ᩘࢆㄪࡿ᪉ἲࢆᵓ⠏ࡍࡿࡓࡵࠊ ࣀࢬࢆᣢࡘ⚄⤒⣽⬊ࣔࢹࣝࡢ┦✵㛫యࡢࢲ ࢼ࣑ࢡࢫࢆㄪࡿࡇࡀ㔜せ࡞ࡿࠋ௨ୖࡢほⅬ ࡛ࠊୗグࡢ㸱ࡘࡢࢸ࣮࣐㛵ࡋ࡚◊✲ࢆᐇࡋࡓࠋ 㸯㸬ࢩࢼࣉࢫࣀࢬ㸦ࢪࣕࣥࣉ㐣⛬࡛グ㏙㸧࠾ࡼ ࡧ࢜ࣥࢳࣕࢿࣝࣀࢬ㸦ᣑᩓ㐣⛬࡛グ㏙㸧ࢆᣢ ࡘ☜⋡ⓗ⚄⤒ືᏊࡢࢲࢼ࣑ࢡࢫࢆㄪࡓࠋ☜ ⋡ⓗ⚄⤒ືᏊࡢ≧ែࡀࠊ࠶ࡿ㛫ᚋࠊࡢ≧ែ ᥎⛣ࡍࡿࢆ⾲ࡍ᥎⛣☜⋡ᐦᗘࡢ㏆ఝࢆィ⟬ࡋ ࡓࠋ᥎⛣☜⋡ᐦᗘࡢ㏆ఝᘧࡢ⢭ᗘࢆࣔࣥࢸ࢝ࣝࣟ ἲࢆ⏝࠸᳨ドࡋࡓࠋ㏆ఝᘧࡣ✚ศࢆక࠸ࠊࡑࡢᩘ ್ィ⟬࡛ࡣᩘ್✚ศἲࢆᕤኵࡍࡿᚲせࡀ࠶ࡗࡓࠋ ࢪࣕࣥࣉࡢᩘࡀᑡ࡞࠸ሙྜࡔࡅ࡛࠶ࡿࡀࠊᩘ್✚ ศᡂຌࡋࠊ᥎⛣☜⋡ᐦᗘ㛵ࡋゎᯒࢆ⾜ࡗࡓࠋ 㸰㸬ᡃࠎࡣࡇࢀࡲ࡛ࡶ☜⋡ⓗ⚄⤒⣽⬊ࣔࢹࣝࡢ ࡿ⯙࠸ࢆゎᯒࡍࡿࡓࡵ⥺ᙧస⏝⣲ࢆ⏝࠸࡚ࡁࡓࠋ ☜⋡ⓗ⚄⤒⣽⬊ࣔࢹࣝࡢ⥺ᙧస⏝⣲ࢆ㞳ᩓࡋࠊ ࡑࡢࢫ࣌ࢡࢺࣝࢆィ⟬ࡋࠊࣔࢹࣝࡢࢲࢼ࣑ࢡࢫ ࢆゎᯒࡍࡿࡀࠊ༢⣧࡞㞳ᩓ࡛ࡣᚓࡽࢀࡿ⾜ิࡢ ḟᩘࡀࡁࡃ࡞ࡗ࡚ࡋࡲ࠸ࠊࡑࡢࢫ࣌ࢡࢺࣝ≉ᛶ ࡢィ⟬ࡀ㞴ࡋࡃ࡞ࡿࠋᡃࠎࡣ┤ภᩘ⣔࡛ Wiener 㐣⛬ࢆࣀࢬ㡯ࡋ࡚ᣢࡘ☜⋡ⓗ⚄⤒⣽⬊ࣔࢹࣝ ࡢ⥺ᙧస⏝⣲ࢆᒎ㛤ࡋࠊࡢ⛬ᗘࡢḟᩘࡢ⾜ิࡲ ࡛⦰⣙ࡍࡿࡇࡀ࡛ࡁࡿヨࡳࡓࠋ ⭷㟁ࢹ࣮ࢱࢆゎᯒࡍࡿྠࡌධຊ▐࿘Ἴᩘࡢ ್ᑐࡋࠊฟຊ▐࿘Ἴᩘࡢ್ࡀࠊࡑࢀࡲ࡛ධຊ ▐࿘Ἴᩘࡀ༢ㄪቑຍࡋࡓ༢ㄪῶᑡࡋࡓ࡛␗ ࡞ࡗࡓࠋࡍ࡞ࢃࡕࢫࣃࢡ⏕ᡂࡣ㐣ཤࡢ⚄⤒άື ౫Ꮡࡍࡿࠋࡇࡢ౫Ꮡࡢ᪉ࢆヲ⣽ゎᯒࡋࠊࡉ ࡽࠊ☜⋡ⓗ⚄⤒⣽⬊ࣔࢹࣝࡢ⤫ィⓗᇦᣲືࢆ ⾲ࡍ⥺ᙧస⏝⣲ࢆ⏝࠸ࠊᐇ㦂࡛”ฟຊ㛵ᩘ”ࢆྠᐃ ࡍࡿ᪉ἲࡢᵓ⠏ࢆヨࡳࡓࠋ ᏛⓎ⾲ 1. ᒣ㔝㎶㈗ಙ㸪⚄⤒⣽⬊ࡣࡢࡄࡽ࠸ಙ㢗࡛ࡁࡿ ࢹࣂࢫ㸽㸪Ⓨⓗ⾜ືࡢㄆ▱ືຊᏛ◊✲ ➨㸰ᅇᐃ◊✲㸪㸰㸮㸯㸴ᖺ㸰᭶㸰㸲᪥㸪㧗▱ 2. Takanobu Yamanobe, Global dynamics of a stochastic neuronal oscillator, mathsci seminar, Hokkaido University, Dec. 21, Sapporo (2015) 3. T. Yamanobe, Transient dynamics of neurons and the information carrier in nervous sytems, The 16th RIES-Hokudai International Symposium, Nov. 11, Sapporo, (2015) (invited talk) 4. ▼ᕝಖᚿ㸪ᒣ㔝㎶㈗ಙ㸪 Nerve cell model and asymptotic expansion (2) 㸪ඹྠ◊✲㞟ࠕ↓㝈ศゎ ྍ⬟㐣⛬㛵㐃ࡍࡿㅖၥ㢟ࠖ㸪㸰㸮㸯㸳ᖺ㸯㸰᭶ 㸲᪥㸪⤫ィᩘ⌮◊✲ᡤ㸪ᮾி 5. T. Yamanobe, Analysis of the dependence of spike generation on the past neuronal activity, Neuroscience 2015, Oct. 17, Chicago, (2015) 6. ᒣ㔝㎶㈗ಙ㸪☜⋡ⓗ⚄⤒⣽⬊ࣔࢹࣝࡢ⤫ィⓗ ᇦᣲືࡽ⚄⤒ሗ࢟ࣕࣜࢆ᥈ࡿ㸪Ⓨⓗ⾜ື ࡢㄆ▱ືຊᏛ◊✲ ➨㸯ᅇ࢟ࢵࢡ࢜ࣇ◊✲㸪 㸰㸮㸯㸳ᖺ㸳᭶㸯㸶᪥㸪Ⓩู ་Ꮫᑓᨷ እ⛉Ꮫㅮᗙ ᒾぢ ᇶ ᡃࠎࡣ㸰㸮㸯㸳ᖺ㸯㸯᭶ࡼࡾࢤࣀ࣒ࢲࢼ࣑ࢡࢫ ࢭࣥࢱ࣮ࢆ⏝ࡉࡏ࡚࠸ࡓࡔ࠸࡚࠸ࡿࠋ ᮏࢭࣥࢱ࣮࠾࠸࡚⾜ࡗ࡚࠸ࡿࡇࡣᐇ㦂⏝ ࡍࡿࡓࡵࡢື≀㸦ࣛࢵࢺ㸧ࡢ㣫⫱ࠊ㓄࠾ࡼࡧࡑ ࢀࡽࡢ⭈⛣᳜ᡭ⾡࡛࠶ࡿࠋ ලయⓗࡣࢻࢼ࣮ࡋ࡚⢾ᒀ⮬↛Ⓨࣔࢹ࡛ࣝ 㸱㸬ࢫࣃࢡ⏕ᡂᚲ㡲ࡢ࢜ࣥࢳࣕࢿࣝࢆᣢࡘ ࠶ࡿ SDT ࣛࢵࢺࢆࣞࢩࣆ࢚ࣥࢺࡣ㏆⦕ࡢ㏆⣔ ࢝ᕧ㍈⣴ࡢ⭷㟁ࢹ࣮ࢱࢆ⏝࠸ࠊࡑࡢᛂ⟅ࡀ ࣛࢵࢺ࡛࠶ࡿ SDJ㸦⏣ࣛ࣎ࡼࡾࡈᥦ౪㸧 SDT ࡢࡼ࠺㐣ཤࡢ⚄⤒άື౫Ꮡࡍࡿࡉࡽゎ ࣛࢵࢺࡢ F1 ࣛࢵࢺࢆ⏝࠸ࡿࡓࡵࠊSDT ࣛࢵࢺࡢ㣫 ᯒࢆຍ࠼ࡓࠋᐇ㦂࡛ࡣࠊᖜࡀ୍ᐃ࡛ࠊ▐࿘Ἴ ⫱ࠊSDT ࣛࢵࢺ SDJ ࣛࢵࢺࡢ㓄࠾ࡼࡧࡑࡢ F1 ᩘ㸦ࣃࣝࢫ㛫㝸ࡢ㏫ᩘ㸧ࡀࠊ࠶ࡿ୍ᐃࡢ⠊ᅖ࡛༢ ࣛࢵࢺࡢ㣫⫱ࢆ⾜ࡗ࡚࠸ࡿࠋ ㄪῶᑡࡲࡓࡣ༢ㄪቑຍࡍࡿධຊࢆࡃࢃ࠼࡚࠶ࡗࡓࠋ ࡲࡓࠊ⭈⛣᳜ᡭ⾡ࡘ࠸࡚ࡣ⌧ᅾࡲ࡛ィ 20 ௳ − 10 − ⾜ࡋ࡚࠾ࡾࠊ࠾࠾ࡴࡡᡭᢏⓗ࡞ၥ㢟ࢆࡾ㉺࠼ ࡚Ᏻᐃࡋ࡚ᡭ⾡ࢆ⾜࠼ࡿࡼ࠺࡞ࡗࡓࠋ ᚋࡣ SDT ࣛࢵࢺࡢ⢾ᒀ⭈ࡀṇᖖ⪏⢾⬟ࡢ SDT/SDJ F1 ࣛࢵࢺ⛣᳜ࡉࢀࡓ࠶ᶵ⬟ⓗࠊ⤌⧊ Ꮫⓗࡢࡼ࠺᥎⛣ࡋ࡚ࡺࡃࡢࠊ⤒ⓗ⤒ 㐣ࢆ㏣ࡗ࡚ࡺࡁࢹ࣮ࢱࢆ✚ࡍࡿணᐃ࡛࠶ࡿࠋࡉ ࡽࠊࡑࡢ⤒ⓗኚᑐࡋ࡚ྛ✀චᢚไࡀ ࡢࡼ࠺࡞ᙳ㡪ࢆ࠶ࡓ࠼ࡿࡢࡘ࠸࡚ࡶ᳨ウࡍ ࡿணᐃ࡛࠶ࡿࠋ Hehlgans T, Bromberg JS. IL-10 from marginal zone precursor B cells controls the differentiation of Th17, Tfh and Tfr cells in transplantation tolerance. Immunol Lett. 2016 Feb;170:52-63. (IF=2.355) 6) Xiong Y, Ahmad S, Iwami D, Brinkman CC, Bromberg JS. T-bet Regulates Natural Regulatory T Cell Afferent Lymphatic Migration and Suppressive Function. J Immunol. 2016 Feb 15. [Epub ahead of print] (IF=4.922) ⌧ᅾࡲ࡛ࡢ㐩ᡂᗘ ᴫࡡ㡰ㄪ㐍ᒎࡋ࡚࠸ࡿ ሗ࿌ 1) Iwami D *, Ogawa Y, Fujita H, Morita K, Sasaki H, Oishi Y, Higuchi H, Hatanaka K, Shinohara N. Successful treatment with foscarnet for ganciclovir-resistant cytomegalovirus infection in a kidney transplant recipient: A case report. Nephrology (Carlton). 2016 Mar 10. [Epub ahead of print] (IF=2.083) ᚋࡢ◊✲ࡢ᥎㐍᪉⟇ ᖺᗘ⾜ࡗࡓ⭈⛣᳜ࣛࢵࢺࡢ DN ኚࡢྍ㏫ᛶ ࢆᘬࡁ⥆ࡁ☜ㄆࡋ࡚ࡺࡃࠋࡉࡽḟᖺᗘࡣࡑࡢ⤌ ⧊Ꮫⓗ࠾ࡅࡿචᢚไࡢᙳ㡪ࢆ᳨ウࡍࡿࠋච ᢚไࡋ࡚ࡣ࢝ࣝࢩࢽ࣮ࣗࣜࣥ㜼ᐖ⸆࡛࠶ࡿ ࢱࢡ࣒ࣟࣜࢫ㸦TAC㸧ࢩࢡࣟࢫ࣏ࣜࣥ㸦CsA㸧ࠊ ௦ㅰᣕᢠ⸆࡛࠶ࡿ࣑ࢥࣇ࢙ࣀ࣮ࣝ㓟㸦MMF㸧ࠊ mTOR 㜼ᐖ⸆࡛࠶ࡿࢩ࣒ࣟࣜࢫ㸦mTORi㸧ࢆ⏝ ࡍࡿࠋ⩌ศࡅࡋ࡚චᢚไࢆᢞࡏࡎ⛣᳜ࢆ ⾜ࡗࡓ⛣᳜⩌ࠊචᢚไࢆᢞࡍࡿ⛣᳜㸩CsA ⩌ࠊ⛣᳜㸩TAC ⩌ࠊ⛣᳜㸩MMF ⩌ࠊ⛣᳜㸩mTORi ⩌ࢆタࡅࡿࠋ ⱥᩥㄽᩥ㸦ᰝㄞ࠶ࡾࡢࡳ㸧 ཎⴭ 1) Iwami D, Brinkman CC, Bromberg JS. VEGF-C/VEGFR-3 Signaling Regulates Chemokine Gradients and Lymphocyte Migration from Tissues to Lymphatics. Transplantation 2015 Apr;99(4):668-77. (IF=3.548) 2) Burrell BE, Warren KJ, Nakayama Y, Iwami D, Brinkman CC, Bromberg JS. Lymph Node Stromal Fiber ER-TR7 Modulates CD4+ T Cell Lymph Node Trafficking and Transplant Tolerance. Transplantation. 2015 Mar 12. (IF=3.548) 3) Lal G, Nakayama Y, Sethi A, Singh AK, Burrell BE, Kulkarni N, Brinkman CC, Iwami D, Zhang T, Bromberg JS.Interleukin-10 From Marginal Zone Precursor B-Cell Subset Is Required for Costimulatory Blockade-Induced Transplantation Tolerance. Transplantation. 2015 Apr 3. (IF=3.548) 4) Mitsui T, Moriya K, Morita K, Iwami D, Kitta T, Kanno Y, Takeda M, Shinohara N. Risk Factors for Lower Urinary Tract Dysfunction and Symptoms After Successful Renal Transplantation. Ann Transplant. 2015 Dec 24;20:757-763. (IF=1.261) 5) Lal G, Kulkarni N, Nakayama Y, Singh AK, Sethi A, Burrell BE, Brinkman CC, Iwami D, Zhang T, ࢩ࣏ࣥࢪ࣒࢘ 1) ᒾぢᇶࠊ࣐࢘ࢫࢻࢼ࣮≉␗ⓗචᐶᐜㄏᑟ ࠾ࡅࡿᶫΏࡋ◊✲ࡢ᪉ἲㄽࠊࢩ࣏ࣥࢪ࣒࢘ࠕ⛣ ᳜་ࡼࡿTranslational research᭱๓⥺ࠖ➨48 ᅇ᪥ᮏ⮫ᗋ⭈⛣᳜Ꮫࠊྡྂᒇࠊ2015 2) ᒾぢᇶࠊ᳃⏣◊ࠊబࠎᮌඖࠊ㧗⏣♸㍜ࠊ⠛ཎ ಙ㞝 ࠕ⭈⛣᳜ᚋ៏ᛶᢠయ㛵㐃ᆺᣄ⤯ᛂⓎ ࣑ࢫ࣐ࢵࢳHLA epletࡢ㛵ಀࡢ᳨ウࠖ ࢩ ࣏ࣥࢪ࣒࢘ ⛣᳜་⒪࠾ࡅࡿᢠయ㸫⌧≧ ㄢ㢟㸫 ➨㸰㸲ᅇ᪥ᮏ⤌⧊㐺ྜᛶᏛᏛ⾡㞟 Ỉᡞ 2015/9/10-12 ᅜෆᏛ(ᅜᏛ㝈ࡿ) ୍⯡Ⓨ⾲ 1) ᒾぢᇶࠊ᳃⏣◊ࠊᵽཱྀࡣࡿࠊ▼ᝆ୍㑻ࠊ బࠎᮌඖࠊ⠛ཎಙ㞝㸸⾑ᾮᆺ㐺ྜḟ⏕య⭈ ⛣᳜ᚋⓎࡋ foscarnet ᢞ࡛⒵ࡋᚓࡓ GCV ⪏ᛶ CMV ึឤᰁࡢ㸯ࠊ➨ 31 ᅇ⭈⛣ ᳜⾑⟶እ⛉◊✲ ᪥ගࠊ2015/7/10-11 2) ᒾぢᇶࠊ⸨⏣⿱⨾ࠊᑠᕝᘺ⏕ࠊ᳃⏣◊ࠊ▼ ᝆ୍㑻ࠊᵽཱྀࡣࡿࠊబࠎᮌඖࠊ⏿୰ెዉᏊࠊ ⠛ཎಙ㞝: ࠕGCV ⪏ᛶ CMV ឤᰁ⒪୰ foscarnet ⭈㞀ᐖࡀ ࢃࢀࡓ⾑ᾮᆺ㐺ྜ ḟ⭈⛣᳜ࡢ㸯ࠖ ⛣᳜⭈⌮◊✲➨㸯㸷ᅇ Ꮫ⾡㞟 ᮾி 2015/7/25 3) ᒾぢᇶࠊ᳃⏣◊ࠊబࠎᮌඖࠊ㧗⏣♸㍜ࠊ⠛ཎ ಙ㞝ࠕ⭈⛣᳜ᚋ៏ᛶᢠయ㛵㐃ᆺᣄ⤯ᛂⓎ ࣑ࢫ࣐ࢵࢳ HLA eplet ࡢ㛵ಀࡢ᳨ウࠖ ➨㸳㸯 ᅇ᪥ᮏ⛣᳜Ꮫ⥲ ⇃ᮏ 2015/10/1-3 4) ᒾぢᇶࠊ୰ᮧఙࠊ᳃⏣◊ࠊ㧗⏣♸㍜ࠊబࠎ ᮌඖࠊ୕ዲ⚽᫂ࠊ⠛ཎಙ㞝ࠕOGTTࢆ⏝࠸ࡓ⛣ ᳜ᚋ⪏⢾⬟ࡢኚࡑࡢᙳ㡪ᅉᏊࡢ᳨ウࠖ ➨ 㸳㸯ᅇ᪥ᮏ⛣᳜Ꮫ⥲ ⇃ᮏ 2015/10/1-3 − 11 − 5) ᒾぢᇶࠊ୰ᮧఙࠊ᳃⏣◊ࠊ㧗⏣♸㍜ࠊబࠎ ᮌඖࠊ୕ዲ⚽᫂ࠊ⠛ཎಙ㞝ࠕOGTTࢆ⏝࠸ࡓ⭈ ⛣᳜ᚋ㸯ᖺࡢ⪏⢾⬟ࡢኚࡑࡢᙳ㡪ᅉᏊ ࡘ࠸࡚ࠖ ➨㸷㸳ᅇ་ᏛἪᒀჾ⛉ศ⛉ 㸦➨㸱㸷㸴ᅇ᪥ᮏἪᒀჾ⛉Ꮫᾏ㐨ᆅ᪉㸧 ᮐᖠ 2015/10/17 6) ᒾぢᇶࠊ᳃⏣◊ࠊబࠎᮌඖࠊ▼ᝆ୍㑻ࠊᵽ ཱྀࡣࡿࠊ㧗⏣♸㍜ࠊ⠛ཎಙ㞝 ࠕ⭈⛣᳜࠾ ࡅࡿࢻࢼ࣮」ᩘ⭈ື⬦ࡢ᳨ウࠖ ➨㸰㸷ᅇ ᪥ᮏἪᒀჾෆど㙾Ꮫ⥲ 2015/11/19-21 ᮾ ி ᕷẸබ㛤ㅮᗙ 7) ᒾぢᇶ㸸 ࠕࡇࢀࡽࡢ⭈⛣᳜ࠖ ぢᕷᕷ Ẹබ㛤ㅮᗙࠥ᪂ࡋ࠸⭈⛣᳜ࡢᣮᡓࠥ ぢࠊ 2015/5/17 8) ᒾぢᇶ㸸 ࠕ⫹ᆅ༊ࡢCKDᝈ⪅ࡉࢇࡢ⭈ ⛣᳜㛵ࡍࡿ⮫ᗋⓗ᳨ウࠖ➨8ᅇ Ɫᑠ∾ CKDデ㐃ᦠᏛ⾡ㅮ₇ Ɫᑠ∾ 2015/7/16 9) ᒾぢᇶ㸸 ࠕ᭱㏆ࡢ⭈⛣᳜ࠊࡇࢀࡽࡢ⭈⛣ ᳜ࠖ ࡑࡽࡲࡵࡢ ᮐᖠ 2015/7/19 10) ᒾぢᇶ㸸 ࠕ᭱㏆ࡢ⭈⛣᳜ࠊࡇࢀࡽࡢ⭈⛣ ᳜ࠖ ⭈ Ɫᑠ∾ 2015/10/18 ᅜ㝿Ꮫ 1) Iwami D, Morita K, Sasaki H, Oishi Y, Higuchi H, Shinohara N: “2mm” is Reasonable and Feasible Cutoff Value of Indication for Vascular Reconstruction in a Kidney Allograft with Multiple Arteries, American Transplant Congress, Philadelphia, 2015 2) Iwami D, Morita K, Fujita H, Oishi Y, Higuchi H, Sasaki H, Shinohara N, ”Higher Donor Age is a Significant Predictor for TAC-induced Nephrotoxicity in Kidney Allografts Long Term after Transplant”ESOT Brussells, Belgium, 2015/9/13-16 Ꮫ㝔ᆅ⌫⎔ቃ⛉Ꮫ◊✲㝔 ⤫ྜ⎔ቃ⛉Ꮫ㒊㛛 ⮬↛⎔ቃಖศ㔝 㟢ᓮ ྐᮁ ⏝⪅: ㉿᪂㞷࣭࿘⅋⅋࣭ᙇ࣭Mukhlish Jamal Musa Holle࣭Lea Végh ✀ᏊⓎⱆ࣭ᐇ⏕ᡂ㛗࣭ᰤ㣴⦾Ṫ㛵ࡍࡿ⎔ቃ᧯స ᐇ㦂 ྛ✀ࡢ✀ᏊⓎⱆ࣭ᡂ㛗≉ᛶࢆ᫂ࡽࡍࡿࡇ ࡣࠊ⏕ែ⣔Ⓨ㐩㐣⛬ࢆ▱ࡿୖ࡛㔜せ࡛࠶ࡿࠋࡑࡇ ࡛ࠊ ᐊ࠾࠸࡚᳜≀ࡢⓎⱆᡂ㛗㛵ࡍࡿ 3 ᐇ㦂 ࢆ⾜ࡗࡓࠋᐇ㦂࡛Ⓨⱆ⏕⫱ᗋࡣ⦪ 20 cm × ᶓ 15 cm × ῝ࡉ 5 cm ࡢࣉࣛࢫࢳࢵࢡࢺࣞࢆ⏝࠸ࡓࠋ (1) ✀ᏊⓎⱆ࣭ᡂ㛗ᐇ㦂 ࢟ࣀ࢟ࣜࣥࢯ࢘(Solidago virgaurea)ࡣࠊ‵ཎ ࡽⲨᆅࡲ࡛ࡢᵝࠎ࡞⏕ᜥᆅᐃ╔ࡋ࡚࠸ࡿࠋ‵ཎ ࠾࠸࡚ᮏ✀ࡀᐃ╔࡛ࡁࡿせᅉࢆ▱ࡿࡓࡵࠊ10 ᭶ୗ᪪㐨࡛᥇ྲྀࡋࡓᮏ✀✀Ꮚᑐࡋ࡚ࠊᅵተ (ᇶ㉁)࣭⫧ᩱ⃰ᗘࢆ᧯సࡋࡓ✀ᏊⓎⱆ࠾ࡼࡧᐇ⏕⏕ ⫱ᐇ㦂ࢆ⾜ࡗࡓࠋⓎⱆࡽ 1 ࣨ᭶ᚋ NDVI(᳜ ⏕ᣦᩘ)ࢆ ᐃࡋࠊ⏕Ꮡᐇ⏕ࢆสࡾྲྀࡾᆅୖ㒊ᆅ ୗ㒊ศࡅࣂ࣐࢜ࢫࢆ ᐃࡋࡓࠋᅵተࡣ࣑ࢬࢦ ࢣࣆ࣮ࢺࣔࢫࡢ 2 ✀㢮ࠊ⫧ᩱ⃰ᗘࡣ 0, 0.09, 0.45 g/100 cc/㐌ࡢ 3 ✀㢮ࡋࡓࠋ30 ࢺࣞࠊࡑࢀࡒ ࢀ 50 ✀Ꮚࢆ✀ࡋࠊࢫࣉࣜࣥࢡ࣮ࣛᩓỈࢆ᪥ 7 ᅇ(30 ⛊)⾜ࡗࡓࠋ୍ᅇࡢᩓỈ㔞ࡣࠊᖹᆒ 0.032 ml/cm2 ࡛࠶ࡿࠋⓎⱆᩘࡣⓎⱆࡲ࡛ẖ᪥グ㘓ࡋ ࡓࠋⓎⱆࣃࢱ࣮ࣥࡣࠊᇶ㉁ࡣᙳ㡪ࡉࢀ࡞ࡗࡓࠋ ࣂ࣐࢜ࢫ࠾ࡼࡧࣟࢣ࣮ࢩࣙࣥࡣࠊᇶ㉁ࡼࡾࡶ ࡴࡋࢁ⫧㔞ࡼࡾኚືࡋ࡚࠸ࡓࠋᆅୖ㒊ࣂ࢜ ࣐ࢫࡣᆅୗ㒊ࣂ࣐࢜ࢫࡼࡾ㧗࠸್ࢆ♧ࡋࡓࠋ ࢟ࣀ࢟ࣜࣥࢯ࢘㏆⦕࡛࠶ࡿࡀᖐ᳜≀࡛࠶ࡿ࢜ ࢜࣡ࢲࢳࢯ࢘(S. gigantea)ࡘ࠸࡚ࠊᩓỈ㔞ࢆኚ ࠼ࡓ௨እࡣୖグྠᵝࡢᐇ㦂ࢆ⾜ࡗࡓࠋ࢜࢜࣡ ࢲࢳࢯ࢘ࡣࠊ࢟ࣀ࢟ࣜࣥࢯ࢘ẚ⇱ࡋࡓᅵ ተ࠾࠸࡚Ⓨⱆ࣭ᡂ㛗ࡀⰋዲ࡛࠶ࡿࡇࡀ♧ࡉࢀ ࡓࠋ ࣞࢴ࣐ࢶࣚࢢࢧ(Oenothera biennis)ࡢⓎⱆ≉ ᛶᑐࡍࡿࣜࢱ࣮㔞ࡢᙳ㡪ࢆᢕᥱࡍࡿࡓࡵࠊࣜ ࢱ࣮㔞ࢆኚࡉࡏࡓᐇ㦂ࢆ⾜ࡗࡓࠋ✀Ꮚ࠾ࡼࡧࣜ ࢱ࣮ࡣ 2015 ᖺ 11 ᭶ᵓෆࡽ᥇ྲྀࡋࡓࠋࣜ ࢱ࣮ࡣࢩࣛ࢝ࣥࣂⴥࢆ⏝࠸ࡓࠋᮏ✀ࡢ✀ᏊⓎⱆ ࡣࠊప ฎ⌮ࡀᚲせ࡞ࡓࡵᜏ ჾෆ ᗘࢆ 2oC タᐃࡋ 3 㐌㛫ࡅ࡚‵ᒙฎ⌮ࢆ⾜ࡗࡓࡶࡢ⾜ ࢃ࡞ࡗࡓࡶࡢࢆⓎⱆᐇ㦂౪ࡋࡓࠋࣜࢱ࣮ࡣࠊ 0, 1.5, 3, 6 g/ࢺࣞタᐃࡋ 50 ✀Ꮚ✀ࢆ 5 ‽ഛࡋ ᐊ࡛ᐇ㦂ࢆ⾜ࡗࡓࠋ✀௨㝆ࠊẖ᪥Ⓨⱆ ᩘࢆ ᐃࡋࡓࠋࣜࢱ࣮ࡢ࡞࠸ࢺ࡛ࣞࠊⓎⱆ㛤ጞ ࡣ㠀‵ᒙฎ⌮✀Ꮚ࡛᪩ࡗࡓࡀⓎⱆ⋡ࡣ 12.4% పࡗࡓࠋ୍᪉ࠊ‵ᒙฎ⌮✀Ꮚ࡛ࡣⓎⱆ⋡ࡣ 65.6% 㐩ࡋࡓࠋ࡚ࡢࣜࢱ࣮ฎ⌮༊࡛ࡣࠊⓎⱆ⋡ࡣ 8% ௨ୗ࡛࠶ࡗࡓࠋࡇࢀࡽࡢࡇࡽࠊ࢜࢜࣡ࢲࢳ ࢯ࢘ࡣഹ࡞ࣜࢱ࣮✚࡛ࡶ✀ᏊⓎⱆࡀࡁࡃ㜼 ᐖࡉࢀࡿࡇࡀ᫂ࡽ࡞ࡗࡓࠋ (2) ᇙᅵ✀ᏊⓎⱆᐇ㦂 (⥅⥆୰) ᳜⏕ᅇࡣࠊᅵተ୰ᇙᅵࡋࡓ✀Ꮚࣂࣥࢡࡀ 㛵ࡋ࡚࠸ࡿࠋࡑࡇ࡛ࠊ᭷⌔ᒣ࠾࠸࡚ 1910 ᖺᄇ ⅆᚋⓎ㐩ࡋࡓ」ᩘࡢ᳜⏕ࡽ 100 cc ࡢᅵተࢆྜ ィ 70 ⟠ᡤࡽ᥇ྲྀࡋࠊⓎⱆᐇ㦂ࢆ⾜ࡗ࡚࠸ࡿࠋࡇ ࢀࡲ࡛ࠊ127 ᐇ⏕ࡀⓎ⏕ࡋࠊᮍྠᐃᐇ⏕ࡘ࠸ ࡚ࡣูࢸ࣮ࣈࣝ⛣ࡋ⏕⫱ࡉࡏ࡚࠸ࡿࠋ − 12 − (3) ᰤ㣴⦾Ṫᐇ㦂 (⥅⥆୰) 㐨 ෆ ࡢ ⅆ ᒣ ᆅ ᇦ ඃ ༨ ࡍ ࡿ ࣑ ࢿ ࣖ ࢼ ࢠ (Salix reinii)ࣃࢵࢳࡣࠊ✀ࡢධᐃ╔ࡁࡃᙳ㡪ࡋ࡚ ࠸ࡿࠋࡑࡇ࡛ࠊ࣑ࢿࣖࢼࢠᯞ᮲ࢆࢺࣞ୰࡛Ⓨ᰿ ᡂ⫱ࡉࡏᯞ᮲ᐦᗘ(5, 7, 9 ᯞ/ࢺࣞ, 5 )ࡀ✀Ꮚ Ⓨⱆᐇ⏕ᡂ㛗࠼ࡿᙳ㡪ࢆ᳨ฟࡍࡿ┠ⓗ࡛ᐇ 㦂ࢆ⾜ࡗ࡚࠸ࡿࠋᮏᖺ⛅Ώᓥ㥖ࣨᓅ࡛ඃ༨✀✀ Ꮚࢆ᥇ྲྀࡋࠊࡑࢀࡽࢆᐇ㦂ࣃࢵࢳ୰✀ࡋⓎ ⱆ࣭ᡂ㛗ࢆ ᐃࡍࡿணᐃ࡛࠶ࡿࠋࡑࡢࡓࡵࠊணഛ ẁ㝵ࡋ࡚࣑ࢿࣖࢼࢠࡢⰋዲ࡞Ⓨ᰿᮲௳ࢆ▱ࡿࡓ ࡵ ᐊ࡚Ⓨ᰿ᐇ㦂ࢆヨࡳࡓࠋ2015 ᖺ⛅㥖ࣨ ᓅ࡚࣑ࢿࣖࢼࢠᯞ᮲ࢆ᥇ྲྀࡋࠊࡇࢀࡽⓎ᰿ಁ 㐍ᾐₕࡋⓎ᰿☜ㄆᚋࢺࣞ⛣᳜ࡋࡓࠋࡋ ࡋࠊከࡃࡢᯞ࡛ࡣࠊⓎ᰿ࡀṆࡋ㛤ⴥࡶぢࡽࢀ ࡞ࡗࡓࠋࡇࡢせᅉࡋ࡚ࠊᯞ᮲᥇ྲྀᮇࠊᅵተ ᰤ㣴ࠊỈࢫࢺࣞࢫ➼ࡀ⪃࠼ࡽࢀࠊࡇࢀࡽࡢⅬࢆᨵ ၿࡋᐇ㦂ࢆ⾜࠺ணᐃ࡛࠶ࡿࠋ ㄽᩥ Hirata, A.K.B. & Tsuyuzaki, S. 2016. 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M., Abdel-Lateff, A., Nogata, Y., Washio, K., Morikawa, M., & Okino, T. (2016) Wewakazole B, a cytotoxic cyanobactin from the cyanobacterium Moorea producens collected in the Red Sea, J. Nat. Prod., DOI 10.1021/acs.jnatprod.6b00051 Ꮫ㝔⌮Ꮫ◊✲㝔 ≀⌮Ꮫ㒊㛛 㔞Ꮚ≀⌮Ꮫศ㔝 ᯇỌ ᝅ᫂ 㸦⣧Ỉ⏝㸧 ࣭ㄽᩥⓎ⾲ K. Nomura, M. Yamamoto, N. Matsunaga, S. Hirose, N. Shimohara, T. Satoh, T. Isome, Y. Liu, and A. Kawamoto (2015) Coexistence of charge order and antiferromagnetism in (TMTTF)2SbF6: NMR study Physica B 460, 53 H. Nobukane, T. Matsuyama, and S. Tanda (2015) Topological electromagnetic response in the chiral superconductor Sr2RuO4 Physica B 460, 168 Y. Oka, H. Nobukane, N. Matsunaga, K. Nomura, K. Katono, K. Ichimura, and A. Kawamoto (2015) − 13 − STM spectroscopy on Nj-(ET-d[3,3])2Cu[N(Cn)2]Br Physica B 460, 93 deuterated Yuki Oka, Noriaki Matsunaga, Kazushige Nomura, Atsushi Kawamoto, Kaoru Yamamoto, and Kyuya Yakushi (2015) Charge Order in (TMTTF)2TaF6 by Infrared Spectroscopy Journal of the Physical Society of Japan, Vol.84, 114709 Takaaki Minamidate, Yuki Oka, Hironori Shindo, Toshitaka Yamazaki, Noriaki Matsunaga, Kazushige Nomura, and Atsushi Kawamoto (2015) Superconducting Phase in Ȣ-(BEDT-STF)2GaCl4 at High Pressures Journal of the Physical Society of Japan, Vol.84, 063704 Yuki Oka, Hiroyoshi Nobukane, Noriaki Matsunaga, Kazushige Nomura, Kazuhiro Katono, Koichi Ichimura, and Atsushi Kawamoto (2015) Tunneling Spectroscopy in Organic Superconductor ȡ-(BEDT-TTF-d[3,3])2Cu[N(CN)2]Br Journal of the Physical Society of Japan, Vol.84, 064713 (2015) ࣭ᏛⓎ⾲ Hiroyoshi Nobukane Chern structure in Sr2RuO4 thin films The 11th International Conference on Materials and Mechanisms of Superconductivity (M2S), August 23-28, 2015, Geneva (Switzerland) T. Minamidate, T. Komada, N. Matsunaga, K. Nomura, T. Sasaki Negative Hall State in the FISDW Phase of (TMTSF)2ReO4 11th International Symposium on Crystalline Organic Metals, Superconductors and Ferromagnets (ISCOM2015), September 6-11, 2015, Bad Gögging (Germany) K. Nomura Superconductivity in nj-(BEDT-STF)2GaCl4 under Pressure 11th International Symposium on Crystalline Organic Metals, Superconductors and Ferromagnets (ISCOM2015), September 6-11, 2015, Bad Gögging (Germany) Y. Saito, M. Matsumoto, T. Minamidate, A. Kawamoto, N. Matsunaga, K. Nomura 13C NMR in Organic Conductor Nj-(BEDT-TTF)2Cu2(CN)3 by Partial BEDT-STF substitution 11th International Symposium on Crystalline Organic Metals, Superconductors and Ferromagnets (ISCOM2015), September 6-11, 2015, Bad Gögging (Germany) ༡⯓Ꮥு㸪ᒸ㞝ᇶ㸪ᒣᓮಇ㝯㸪ᯇỌᝅ᫂㸪㔝ᮧ୍ ᡂ㸪Ἑᮏྖ ࠕȢ-(BEDT-STF)2GaCl4 ࡢ㧗ᅽຊୗ㉸ఏᑟࠖ ᪥ᮏ≀⌮Ꮫ➨ 70 ᅇᖺḟ㸦᪩✄⏣㸧2015 ᖺ 3 ᭶ 21-24 ᪥ ㅮ₇␒ྕ 23pAC-14 㐍⸨ᐶ♩㸪ᒸ㞝ᇶ㸪ᒣᓮಇ㝯㸪ᯇỌᝅ᫂㸪㔝ᮧ୍ ᡂ㸪Ἑᮏྖ ࠕȢ-(BEDT-STF)2GaCl4 ࡢ 1H NMRࠖ ᪥ᮏ≀⌮Ꮫ➨ 70 ᅇᖺḟ㸦᪩✄⏣㸧2015 ᖺ 3 ᭶ 21-24 ᪥ ㅮ₇␒ྕ 23pAC-15 㔝ཱྀ㑳㸪ᯇỌᝅ᫂㸪㔝ᮧ୍ᡂ㸪Ἑᮏྖ ࠕD'-(BEDT-TTF)2IBr2 ࡢ㟁Ⲵ⛛ᗎ┦࠾ࡅࡿㄏ 㟁≉ᛶࠖ ᪥ᮏ≀⌮Ꮫ➨ 70 ᅇᖺḟ㸦᪩✄⏣㸧2015 ᖺ 3 ᭶ 21-24 ᪥ ㅮ₇␒ྕ 24aAB-7 ᘏවၨ⣧㸪ᯇᒣ㇏ᶞ㸪⏣⪽ ࠕSr2RuO4 ࠾ࡅࡿࢳ࣮ࣕࣥኚ㔞ࡢほ ࠖ ᪥ᮏ≀⌮Ꮫ➨ 70 ᅇᖺḟ㸦᪩✄⏣㸧2015 ᖺ 3 ᭶ 21-24 ᪥ ㅮ₇␒ྕ 21pBC-3 ༓ⴥ♸, ᒣᾆ㍜, ᯇỌᝅ᫂, 㔝ᮧ୍ᡂ, Ἑᮏ ྖ ࠕ(TMTTF)2X ࡢࢫࣆࣥᐦᗘἼ┦࠾ࡅࡿ㠀⥺ᙧ 㟁Ẽఏᑟࠖ ᪥ᮏ≀⌮Ꮫ 2015 ᖺ⛅Ꮨ㸦㛵す㸧2015 ᖺ 9 ᭶ 16-19 ᪥ ㅮ₇␒ྕ 17pAF-1 ᒣᓮಇ㝯, ᰗཎ⯆ୡ, ᘏවၨ⣧, ᯇỌᝅ᫂, 㔝ᮧ୍ ᡂ ࠕȡ-(ET)2X ࢼࣀ༢⤖ᬗⷧ⭷࠾ࡅࡿ㟁Ꮚ㍺㏦⌧ ㇟ࠖ ᪥ᮏ≀⌮Ꮫ 2015 ᖺ⛅Ꮨ㸦㛵す㸧2015 ᖺ 9 ᭶ 16-19 ᪥ ㅮ₇␒ྕ 17pAF-13 − 14 − ᘏවၨ⣧, ᯇᒣ㇏ᶞ, ⏣⪽ ࠕSr2RuO4 ࡢ㔞Ꮚࣀ࣐࣮ࣜ⌧㇟ࠖ ࢺ࣏ࣟࢪ࣮ࡀ⣳ࡄ≀㉁⛉Ꮫࡢࣇࣟࣥࢸ ➨ 1 ᅇ㡿ᇦ◊✲㸦ி㒔㸧2015 ᖺ 12 ᭶ 11-13 ᪥ ㅮ ₇␒ྕ P-33 ≀⌮Ꮫ㒊㛛 㟁Ꮚ≀ᛶ≀⌮Ꮫศ㔝 Ἑᮏ ྖ 㸦⣧Ỉ⏝㸧 㺃Paper Y. Saito, A. Kawamoto (2016) Determination of the hyperfine coupling tensor in organic conductors ț-(BEDT-TTF)2X (X=Cu[N(CN)2]Br, Cu(NCS)2) on central 13C sites. Solid State Nuclear Magnetic Resonance 73: 22-30 Takuya Kobayashi, Atsushi Kawamoto (2015) Thermodynamic Evidence of d-Wave Superconductivity of the Organic Superconductor Ȝ-(BETS)2GaCl4. Physical Society of Japan 85: 043705 Kyuya Yakushi, Kaoru Yamamoto, Takashi Yamamoto, Yohei Saito, Atsushi Kawamoto (2015) Raman Spectroscopy Study of Charge Fluctuation in the Spin-Liquid Candidate ț-(BEDT-TTF)2Cu2(CN)3 (2015) Physical Society of Japan 84: 084711 㺃Conference ཎᙪ, ぢὒ㍜, Ἑᮏྖ:ᅽຊୗ NMR ᐇ㦂 ࡼ ࡿ ȕ''-(BEDT-TTF)4[(H3O)Ga(C2O4)3]-C6H5NO2 ࡢ㟁Ⲵ⛛ᗎ≧ែ㉸ఏᑟ≧ែࡢ◊✲. ᪥ᮏ≀⌮Ꮫ ➨ 71 ᅇᖺḟ, 2016 ᖺ 3 ᭶ 19 ᪥, ᮾᏛ㝔ᏛἨ࢟ࣕࣥࣃࢫ(ྎᕷ) Yuki Oka, Noriaki Matsunaga, Kazushige Nomura, Atsuhi Kawamoto, Kaoru Yamamoto, and Kyuya Yakushi (2015) Charge Order in (TMTTF)2TaF6 by Infrared Spectroscopy. Jounal of the Physical Society of Japan 84: 114709 ⸕㇂ᣅᐇ, ぢὒ㍜, ཎᙪ, Ἑᮏྖ:᭷ᶵ㉸ ఏᑟయ ȕ”-(BEDT-TTF)4Pt(CN)4࣭H2O ࡢ㟁Ⲵ⛛ᗎ ┦ࡢ NMR ◊✲. ᪥ᮏ≀⌮Ꮫ ➨ 71 ᅇᖺḟ, 2016 ᖺ 3 ᭶ 19 ᪥, ᮾᏛ㝔ᏛἨ࢟ࣕࣥࣃࢫ(ྎᕷ) Yuki Oka, Hiroyoshi Nobukane, Noriaki Matsunaga, Kazushige Nomura, Kazuhiro Katono, Koichi Ichimura, and Atsushi Kawamoto (2015) Tunneling Spectroscopy in Organic Superconductor ț-(BEDT-TTF-d[3,3])2Cu[N(CN)2]Br. Physical Society of Japan 84: 064713 ⏕ᯇኴ㑻, ᘏවၨ⣧, ᯇỌᝅ᫂, 㔝ᮧ୍ᡂ, Ἑᮏ ྖ: ᭷ᶵᑟయ ț-(BEDT-TTF)2Cu[N(CN)2]Br ࠾ ࡅࡿ␗᪉ⓗ㉸ఏᑟࢠࣕࢵࣉ㸸STM ศග. ᪥ᮏ≀⌮Ꮫ ➨ 71 ᅇᖺḟ, 2016 ᖺ 3 ᭶ 21 ᪥, ᮾᏛ㝔ᏛἨ࢟ࣕࣥࣃࢫ(ྎᕷ) Takaaki Minamidate, Yuki Oka, Hironori Shindo, Toshitaka Yamazaki, Noriaki Matsunaga, Kazushige Nomura, and Atsushi Kawamoto (2015) Superconducting Phase in Ȝ-(BEDT-STF)2GaCl4 at High Pressures. Physical Society of Japan 84: 063704 ༡⯓Ꮥு, 㐍⸨ᐶ♩, ᯇỌᝅ᫂, 㔝ᮧ୍ᡂ, ཎ ᙪ, Ἑᮏྖ: ʌ-d ⣔᭷ᶵᑟయ Ȝ-(BEDT-STF)2FeCl4 ࡢ☢Ẽⓗᛶ㉁. ᪥ᮏ≀⌮Ꮫ ➨ 71 ᅇᖺḟ, 2016 ᖺ 3 ᭶ 22 ᪥, ᮾᏛ㝔ᏛἨ࢟ࣕࣥࣃࢫ(ྎᕷ) T. Kobayashi, Y. Ihara, and A. Kawamoto (2016) Modification of local electronic state by BEDT-STF doping to ț-(BEDT-TTF)2Cu[N(CN)2]Br salt studied by 13C NMR. Physical Review B 93: 094515 Yoshihiko Ihara, Yosuke Futami, and Atsushi Kawamoto (2016) High-Temperature Charge and Structure Anomalies in ȕƍƍ-(BEDT-TTF)4[(H3O)Ga(C2O4)3]·C6H5NO2. Physical Society of Japan 85: 014601 Takaaki Minamidate, Yuki Oka, Hironori Shindo, Toshitaka Yamazaki, Noriaki Matsunaga, Kazushige Nomura, and Atsushi Kawamoto (2015) Superconducting Phase in Ȝ-(BEDT-STF)2GaCl4 at High Pressures. Physical Society of Japan 84: 063704 Shusaku Imajo, Naoki Kanda, Satoshi Yamashita, Hiroki Akutsu, Yasuhiro Nakazawa, Hiroya Kumagai, ༓ⴥ♸, ᒣᾆ㍜, ᯇỌᝅ᫂, 㔝ᮧ୍ᡂ, Ἑᮏ ྖ: (TMTTF)2X ࡢࢫࣆࣥᐦᗘἼ┦࠾ࡅࡿ㠀⥺ᙧ 㟁Ẽఏᑟ. ᪥ᮏ≀⌮Ꮫ 2015 ᖺ⛅Ꮨ, 2015 ᖺ 9 ᭶ 17 ᪥, 㛵すᏛ༓㔛ᒣ࢟ࣕࣥࣃࢫ(྿⏣ᕷ) ⇃㇂ ᾈஓ , ᩪ⸨ ὒᖹ , Ἑᮏ ྖ : ᭷ᶵ ㉸ఏᑟయ ȕ-(BEDT-TTF)2I3 ࡢᖖᅽୗ࠾ࡅࡿ㉸ᚤ⣽⤖ྜࢸࣥ ࢯࣝࡢỴᐃ. ᪥ᮏ≀⌮Ꮫ 2015 ᖺ⛅Ꮨ, 2015 ᖺ 9 ᭶ 17 ᪥, 㛵すᏛ༓㔛ᒣ࢟ࣕࣥࣃࢫ(྿⏣ᕷ) ཎ ᙪ , ぢ ὒ㍜ , Ἑᮏ ྖ : ᭷ᶵ ㉸ఏᑟయ ȕƎ-(BEDT-TTF)4[(H3O)Ga(C2O4)3]࣭C6H5NO2 ࡢ㟼Ỉ ᅽୗ㉸ఏᑟ≧ែ. ᪥ᮏ≀⌮Ꮫ 2015 ᖺ⛅Ꮨ, 2015 ᖺ 9 ᭶ 18 ᪥, 㛵すᏛ༓㔛ᒣ࢟ࣕࣥࣃࢫ(྿⏣ᕷ) − 15 − A. Pustogow, Y. Ihara, A. Kawamoto, M. Dressel: Grußwort: Optical investigation of charge fluctuations in the organic superconductor ȕ”-(BEDT-TTF)4[(H3O)Ga(C2O4)3]C6H5NO2. 11th International Symposium on Crystalline Organic Metals, Superconductors and Magnets, September 8, 2015, BAD GÖGGING, GERMANY. Y. Saito, M. Matsumoto, T. Minamidate, A. Kawamoto, N. Matsunaga, K. Nomura:13C NMR in organic conductor ț-(BEDT-TTF)2Cu2(CN)3 by partial BEDT-STF substitution. 11th International Symposium on Crystalline Organic Metals, Superconductors and Magnets, September 8, 2015, BAD GÖGGING, GERMANY. Y. Ihara, A. Kawamoto, M. Jeong, H. Mayaffre, C. Berthier, M. Horvatic: Non-trivial charge ordering near superconducting transition in ȕ‘‘- (BE DT-T TF)4[(H3O)Ga(C2O4)3]•C6H5NO2. 11th International Symposium on Crystalline Organic Metals, Superconductors and Magnets, September 8, 2015, BAD GÖGGING, GERMANY. ⏕≀⛉Ꮫ㒊㛛 ᙧែᶵ⬟Ꮫศ㔝 ᒣཱྀ ῟ 1) ࣘࣅ࢟ࢳ࣮ࣥࣜ࢞ࢮ ATL ࣇ࣑࣮ࣜࡢᶵ⬟ゎ ᯒࡋ࡚㸪ATL31 ATL6 㔜ኚ␗యࡢゎᯒࢆᐇࡋ ࡓࠋ2 㔜ኚ␗య࡛ࡣ㸪Ⓨⱆึᮇࡢᮏⴥࡢ㯤ࡀほ ᐹࡉࢀࡓࠋヲ⣽࡞ゎᯒࡢ⤖ᯝ㸪ࢡࣟࣟࣇࣝ๓㥑 య࡛࠶ࡿ 5-࣑ࣀࣞࣈࣜࣥ㓟ྜᡂࡢ㜼ᐖࡀཎᅉ࡛ ࠶ࡿࡇࢆ᫂ࡽࡋࡓࠋ [Maekawa et al. PLoS ONE. 2015]ࠋ 2) ᳜≀ࡢ C/N ᛂ⟅ゎ᫂ࡢࡓࡵ㸪C/N ᛂ⟅ኚ␗యࡢ ࢫࢡ࣮ࣜࢽࣥࢢࢆᐇࡋࡓࠋࡑࡢ⤖ᯝ㸪᪂ࡓ࡞ኚ ␗య cni2-D ࢆ༢㞳ࡋࡓࠋࡇࡢኚ␗యࡣ㸪᳜≀࣍ࣝ ࣔࣥ ABA ࡢࢩࢢࢼࣝఏ㐩㛵ࡍࡿ ABI1 㑇ఏᏊ ࡀ㐣Ⓨ⌧ࡋ࡚࠸ࡓࠋヲ⣽࡞ゎᯒࡢ⤖ᯝ㸪ABI1 ࡣ㸪 ABA ࡢ⏕ྜᡂࡸࢩࢢࢼࣝఏ㐩㛵ࡍࡿࡔࡅ࡛ ࡞ࡃ㸪ࡑࢀࡣ⊂❧ࡋ࡚㸪C/N ᛂ⟅ࡶ㛵ࡋ࡚ ࠸ࡿࡇࢆド᫂ࡋࡓࠋ [Lu et al. J. Exp. Bot. 2015]ࠋ 3) ࢩࣟࢾࢼࢬࢼࡢ࣏ࣜ㸿ศゎ㓝⣲ AtCCR4 ࡣ᳜ ≀ࡢᡂ㛗ไᚚከ㠃ⓗ㛵ࢃࡿ㓝⣲࡛࠶ࡿࠋatccr4 ኚ␗ᰴࡀ♧ࡍࢩࣙ⢾㐣⪏ᛶ╔┠ࡋ࡚◊✲ࢆ㐍 ࡵࡓ⤖ᯝ㸪㔜ኚ␗ᰴ࡛ࡣࢩࣙ⢾ࡢྵ᭷㔞ࡀ᭷ព ῶࡗ࡚࠾ࡾ㸪୍᪉࡛ࢹࣥࣉࣥࡢᵓᡂせ⣲ࡢࡦ ࡘ࡛࠶ࡿ࣑࣮ࣟࢫࡀቑ࠼࡚࠸ࡿࡇࡀ᫂ࡽ ࡞ࡗࡓࠋࡉࡽ㸪࣑࣮ࣟࢫࡢቑຍ㛵㐃ࡋࡓ AtCCR4 ࡢᶆⓗ㑇ఏᏊࡣ㸪࣑࣮ࣟࢫྜᡂ㓝⣲࡛ ࠶ࡿ Granule Bound Starch Synthase 1 ࡛࠶ࡿࡇࢆ ᫂ࡽࡋㄽᩥⓎ⾲ࡋࡓࠋ [Suzuki et al. Plant Cell Physiol. 2015]ࠋ 4) ATL31 㑇ఏᏊࡢ㌿ไᚚࡘ࠸᳨࡚ウࡍࡿࡓࡵ㸪 ㌿ㄪ⠇ᅉᏊ WRKY33 ࡘ࠸᳨࡚ウࡋࡓࠋࡑࡢ⤖ ᯝ㸪WRKY33 ࡀཎయឤᰁࡢ ATL31 㑇ఏᏊⓎ⌧ ไᚚ┤᥋ⓗస⏝ࡍࡿࡇࢆド᫂ࡋࡓࠋ [Huarancca Reyes et al. Plant Biotech. 2015]ࠋ 5) ᳜≀ࡢ C/N ᛂ⟅ከ㠃ⓗ࡞⎔ቃࢩࢢࢼࣝࡀ ABA ࢩࢢࢼࣝఏ㐩⤫ྜࡉࢀࡿࡇᑐࡍࡿ⥲ ㄝࢆⓎ⾲ࡋࡓࠋ[Lu et al. Plant Signal. Behav. 2015]ࠋ 㸺ཎⴭㄽᩥ㸼 Maekawa, S., Takabayashi, A., Huarancca Reyes, T., Yamamoto, H., Tanaka, A., Sato, T. and Yamaguchi, J. (2015) Double mutant of atl31 and atl6 develops light intensity-dependent pale-green leaves, which is caused by inhibition of 5-aminolevulinic acid biosynthesis. PLOS ONE 10(2): e0117662 [10.1371/journal.pone.0117662] Lu, Y., Sasaki, Y., Li, X., Matsuura, T., Mori, I.C., Hirayama, T., Sato, T. and Yamaguchi, J. (2015) ABI1 regulates carbon/nitrogen-nutrient signal transduction independently from ABA biosynthesis and canonical ABA signal pathway in Arabidopsis. Published online, Journal of Experimental Botany [10.1093/jxb/erv086] Suzuki, Y., Arae, T., Green, P.J., Yamaguchi, J. and Chiba, Y. (2015) AtCCR4a and AtCCR4b are involved in determining the poly(A) length of Granule-bound starch synthase 1 transcript and modulating sucrose and starch metabolism in Arabidopsis thaliana. Published online, Plant and Cell Physiology [10.1093/pcp/pcv012] Huarancca Reyes ,T., Maekawa, S., Sato, T. and Yamaguchi, J. (2015) The Arabidopsis ubiquitin ligase ATL31 is transcriptionally controlled by WRKY33 transcription factor in response to pathogen attack. Published online, Plant Biotechnology [10.5511/plantbiotechnology.14.1201b] Lu, Y., Yamaguchi, J. and Sato, T. (2015) Integration of C/N-nutrient and multiple environmental signals into the ABA signaling cascade. Plant Signaling Behavior e1048940 [10.1080/15592324.2015.1048940] ⏕≀⛉Ꮫ㒊㛛 ᙧែᶵ⬟Ꮫศ㔝 㧗⏣ Ὀᘯ 㸦㉸⣧Ỉ⏝㸧 㹙ᏛⓎ⾲㹛 1. ኑ ෆ ᝅ ࠊ 㧘 ⏣ Ὀ ᘯ 㸸 ዲ ෭ ⳦ Psychrobacter marinaᖖ ⳦Azotobacter vinelandiiࡢࢯࢡ࢚ࣥ − 16 − 㓟⬺Ỉ⣲㓝⣲࠾ࡅࡿ࣑ࣀ㓟ṧᇶ⨨ࡼࡿ ᗘ≉ᛶࡢᙳ㡪. ➨ 16 ᅇᴟ㝈⎔ቃ⏕≀Ꮫᖺࠊ2015 ᖺ 11 ᭶ 9 ᪥ࠊᮾிᾏὒᏛ࣭ရᕝ࢟ࣕࣥࣃࢫ㸦ᮾி㒔㸧. ⏕≀⛉Ꮫ㒊㛛 ᙧែᶵ⬟Ꮫศ㔝 ⥥ᘬ 㞞 㧗➼㝣ୖ᳜≀࠾ࡅࡿᙧែᙧᡂࡢྍረᛶࡣჾᐁ ཎᇶỴᐃࡢᰂ㌾ᛶ⏤᮶ࡍࡿࠋࡇࢀࡣᬑẁ┠ࡘ ࡞࠸ᆅୗ㒊࡛ࡶྠᵝ࡛࠶ࡾ㸪᰿⣔ࡢⓎ㐩ࡣ⎔ቃ ࡁࡃ౫Ꮡࡍࡿࠋ᰿⣔ࡣ✀Ꮚ᰿࡛࠶ࡿ᰿ࡑ ࢀࡽὴ⏕ࡍࡿഃ᰿ศࡅࡽࢀࡿࡀ㸪ࡇࢀࡽࡢ᰿ ⣔ࡣᵝࠎ࡞≀⌮ⓗ㞀ᐖ㸪ࡓ࠼ࡤ⪔సࡸ⿕㣗ࢆཷ ࡅࡿࠋࡋࡋࡇࡢࡼ࠺࡞㞀ᐖᑐࡋ࡚᰿⣔ࡣ᪂ࡓ ࡞᰿⣔ࢆ⏕ࡍࡿ⬟ຊࡀ࠶ࡾ㸪᳜≀ࡀᅛ╔ᆺࡢ⏕ ά⎔ࢆႠࡴࡇࡀ࡛ࡁࡿ㔜せ࡞せᅉࡶ࡞ࡗ࡚࠸ ࡿࠋᮏ◊✲࡛ࡣ᰿⣔⏕࣓࢝ࢽࢬ࣒ࡢศᏊᇶ┙ࢆ ᫂ࡽࡍࡿࡇࢆ┠ⓗᐇ㦂ࢆ⾜ࡗࡓࠋࢩࣟ ࢾࢼࢬࢼⱆ⏕࠼ࡢ᰿ࡢ୍㒊ࢆษ㝖ࡍࡿࢃࡎ ࡞ഃ᰿ᩘቑຍࡀㄆࡵࡽࢀࡿࠋ୍᪉㸪࣮࢜࢟ࢩࣥᴟ ᛶ␗ື㜼ᐖ 13$ ࢆฎ⌮ࡋࡓ᳜≀࡛ࡣഃ᰿ࡢⓎ㐩 ࡣぢࡽࢀ࡞࠸ࡀ㸪᰿ษ㝖ࡼࡗ࡚ 13$ ↓ฎ⌮⛬ ᗘࡲ࡛ഃ᰿ᩘࢆᅇࡍࡿࡇࡀ࡛ࡁࡿࡇࢆⓎぢ ࡋࡓࠋࡑࡇ࡛࣮࢜࢟ࢩࣥ㠀ᛂ⟅ᛶ✺↛ኚ␗యࡘ ࠸࡚ㄪࡓࡇࢁ㸪ࡰࡍ࡚ࡢኚ␗య࡛᰿ษ㝖 ࡼࡿഃ᰿ᩘࡢቑຍࡀㄆࡵࡽࢀࡓࠋࡑࡇ࡛ഃ᰿࣐ ࣮࣮࢝㑇ఏᏊ㸪᪩ᮇ࣮࢜࢟ࢩࣥㄏᑟᛶ㸪࣮࢜࢟ࢩ ࣥᴟᛶ㍺㏦㛵㐃㑇ఏᏊࡢⓎ⌧ࢆㄪࡓࡇࢁ㸪ࡍ ࡚࠾࠸࡚ቑຍࡋ࡚࠸ࡓࠋࡇࡢࡇࡣ᰿ษ㝖 ࡼࡗ࡚ෆ⏕࣮࢜࢟ࢩࣥ㔞ࡢቑຍࢆ♧ࡋ࡚࠸ࡿࠋࡑ ࡇ࡛࣮࢜࢟ࢩࣥྜᡂ㑇ఏᏊ⩌ࢆㄪࡓࡇࢁ㸪࠶ ࡿྜᡂ㑇ఏᏊࡀㄏᑟࡉࢀ࡚࠾ࡾࡑࡢḞᦆኚ␗య࡛ ࡣ᰿ษ㝖ࡼࡿഃ᰿⏕⬟ࡀపୗࡋ࡚࠸ࡓࠋࡉࡽ ᰿ษ㝖ࡢෆ⏕࣮࢜࢟ࢩࣥ㔞ࢆ ᐃࡋࡓࡇࢁ 㢧ⴭ࡞ቑຍࡀࡳࡽࢀࡓࠋᚑࡗ࡚㸪᰿ษ㝖࠾ࡅࡿ ഃ᰿⏕ࡣ᪂つ࣮࢜࢟ࢩࣥྜᡂࡼࡿ⤖ㄽᅗࡅ ࡽࢀࡿࠋ⌧ᅾࡣ᰿ษ㝖ࡀࡢࡼ࠺࡞࣓࢝ࢽࢬ࣒࡛ ࣮࢜࢟ࢩࣥྜᡂࢆಁ㐍ࡋ࡚࠸ࡿࢆ᥈⣴୰࡛࠶ࡿࠋ ㄽᩥⓎ⾲ UV-B-Induced CPD Photolyase Gene Expression is Regulated by UVR8-Dependent and -Independent Pathways in Arabidopsis. Li, N , Teranishi, M ,Yamaguchi, H ,Matsushita, T, Watahiki, MK, Tsuge, T, Li, SS, Hidema, J. PLANT AND CELL PHYSIOLOGY, 56, 2014-2023. Dongyang and Masaaki K. Watahiki, The 1st Molecular Plant International Symposium, 5th - 8th August 2015, Shanghai, China. Root cutting induces lateral root formation through auxin signaling pathway, Xu Dongyang and Masaaki K. Watahiki, ➨ 57 ᅇ᪥ᮏ᳜≀⏕⌮Ꮫ㸪 2015 ᖺ 3 ᭶㸪 ┒ᒸᕷ Lateral root formation of cut root which bypasses normal pathway of lateral root formation, Xu Dongyang and Masaaki K. Watahiki, 3rd International Life-Science Symposium 㸪 26th November 2015, Sapporo. ⏕≀⛉Ꮫ㒊㛛 ᙧែᶵ⬟Ꮫศ㔝 ఀ⸨ ⚽⮧ ᮏᖺᗘࡣࠊᐇ㦂ᐊࢆ⏝࠸ࢲࢥࣥࢬ࢟ࢆ⏝ ࠸ࡓ⎔ቃᛂ⟅㛵ࡍࡿᐇ㦂ࢆ⾜ࡗࡓࠋࢲࢥࣥࢆ ⏝࠸ࡓᐇ㦂࡛ࡣࠊࢲࢥࣥࢆ⤌⧊ᇵ㣴ࡋࠊ࢝ࣝࢫ ࡋࡓࡶࡢࢆศࡉࡏࡓಶయࢆ⫱⏕ࡋḟୡ௦ࡢ ✀Ꮚࢆᚓࡿࡇࢆྍ⬟ࡋࡓࠋࡇࡢᡭἲࢆ⏝࠸࡚ࠊ ࢝ࣝࢫㄏᑟࡋࡓಶయ㧗 ࢫࢺࣞࢫࢆ࠶ࡓ࠼ࠊ㌿ ⛣ᅉᏊࡢάᛶ≧ែࢆゎᯒࡋࡓࠋࢲࢥࣥࡢ✀Ꮚ ࡣ㓄ࡼࡾప㢖ᗘほᐹࡉࢀࡓࡀࠊ✀Ꮚࢆᚓࡿ ☜❧ࡀపࡃࠊ⏕⫱᮲௳᭦࡞ࡿᕤኵࡀᚲせࡉࢀ ࡓࡓࡵࠊᖺᗘ㏵୰࡛ᐇ㦂ᐊࡢ⏝ࢆṆࡋࡓࠋ ࢬ࢟ࡣ㧗 ᮲௳ୗ࡛άᛶࡍࡿࢺࣛࣥࢫ࣏ࢰࣥ ࡢୡ௦ࢆ㉸࠼ࡓ㌿⛣ࢆゎᯒࡍࡿࡓࡵ✀Ꮚࢆᚓࡿ ᚲせࡀ࠶ࡗࡓࠋࡑࡢࡓࡵ㛤ⰼࡉࡏࡿᚲせࡀ࠶ࡗࡓ ࡀࠊᮇࡢẼ ᮲௳᪥↷᮲௳ࡢไᚚࡀ㞴ࡋࡗ ࡓࡓࡵᖺᗘ㏵୰࡛ᐇ㦂ᐊࡢ⏝ࢆṆࡋࡓࠋ ᏛⓎ⾲ 1. ࢩࣟࢾࢼࢬࢼ࢚ࢥࢱࣉࢆࡶࡕ࠸ࡓ⇕άᛶ ᆺࣞࢺࣟࢺࣛࣥࢫ࣏ࢰࣥࡢ㌿ไᚚゎᯒ 㔝ἑ ⣫భࠊ༖⏣ ㄔࠊຍ⸨ ᩔஅࠊఀ⸨ ⚽⮧ ᪥ᮏ㑇ఏᏛ➨ 87 ᅇ 9 ᭶ 25 ᪥ ᮾ Ꮫ (ᐑᇛ┴ྎᕷ) 2. ᏛⓎ⾲ Lateral root formation of cut root which bypasses normal pathway of lateral root formation, Xu − 17 − Epigenetic regulation of a transposon in plant [ᣍᚅ᭷ࡾ] ఀ⸨ ⚽⮧ ➨ 56 ᅇ᪥ᮏ᳜≀⏕⌮Ꮫᖺ 16 ᪥ ᪥ᮏ᳜≀⏕⌮Ꮫ heat-activated 2015 ᖺ 3 ᭶ 㸱㸬ࢦ࢟ࣈࣜࡢ㛗ᮇグ᠈ᙧᡂ࠾ࡅࡿᢚไ⌧㇟ࡢ ゎᯒ ࣡ࣔࣥࢦ࢟ࣈࣜࡢໝ࠸ࡢ㛗ᮇグ᠈ࡢᙧᡂᚲせ࡞ 㸯㸬ࢥ࢜ࣟࢠࡢᑠ㢡⫥ఙᒎᛂࡢ᮲௳ࡅࢆ⏝࠸ ᮲௳ࡅࡢࣃ࣓࣮ࣛࢱ≉᮲௳ࡅヨ⾜ᅇᩘヨ ࡓᏛ⩦㛵ࢃࡿࣔࣀ࣑ࣥࢽ࣮ࣗࣟࣥࡢྠᐃ ⾜㛫ࡢ㛫㛫㝸ࡘ࠸࡚ࠊᑠ㢡⫥ఙᒎᛂ㸦MER㸧 ⚾㐩ࡢ◊✲ᐊ࡛ࡣᏛ⩦㛵ࢃࡿ⚄⤒ఏ㐩≀㉁ࡘ ࡢ᮲௳ࡅࢆ⏝࠸࡚ゎᯒࡋࡓࠋࢦ࢟ࣈ࡛ࣜࡣࢱࣥ ࠸࡚᥈⣴ࢆ㐍ࡵ࡚ࡁࡓࡀࠊᚑ᮶⏝࠸࡚ࡁࡓࢥ࢜ࣟ ࣃࢡ㉁ྜᡂ౫Ꮡᛶࡢ㛗ᮇグ᠈ࡀカ⦎ᚋࢃࡎ㸯 ࢠࡢᏛ⩦カ⦎ἲࡣᏛ⩦㛵ࢃࡿఏ㐩≀㉁ࢆㄪ 㛫࡛ᡂ❧ࡋࡓࠋࡇࢀࡣࡇࢀࡲ࡛ㄪࡽࢀࡓ᪻ࡢ ࡿୖ࡛ࡢᅛ᭷ࡢၥ㢟Ⅼࡀ࠶ࡾࠊ᭱⤊ⓗ࡞⤖ㄽࢆฟ ୰࡛ࡣ᭱ࡶ᪩ࡗࡓࠋࣄࢺࢆྵࡵࡓከࡃࡢ⬨᳝ື ࡍࡣ⮳ࡗ࡚࠸࡞ࡗࡓࠋࡑࡇ࡛Ꮫ⩦㛵ࢃࡿఏ ≀࣭↓⬨᳝ື≀࠾࠸࡚ࠊ᮲௳ࡅヨ⾜㛫ࡢ㛫 㐩≀㉁ࡢゎᯒ㐺ࡋࡓ᮲௳ࡅἲࢆ᪂ࡓ㛤Ⓨࡋ 㛫㝸ࡀ㛗࠸᪉ࡀࠊヨ⾜㛫ࡢ㛫㝸ࡀ▷࠸ሙྜࡼࡾࡶ ࡓࠋࣇࢱ࣍ࢩࢥ࢜ࣟࢠࡢゐゅࡸཱྀỈࢆࡘࡅࡿࠊ 㛗ᮇグ᠈ࡀᡂ❧ࡋࡸࡍ࠸࠸࠺ཎ๎ࡀ࠶ࡿࡇࡀ ᑠ㢡⫥ࢆఙᒎࡉࡏࠊ⃭ࡋࡃ㟈ࢃࡏࡿᛂࢆ⾜࠺ࠋ ▱ࡽࢀ࡚࠸ࡿࠋࡋࡋࢦ࢟ࣈ࡛ࣜࡣ᮲௳ࡅヨ⾜ ࡇࢀࢆᑠ㢡⫥ఙᒎᛂ㸦MER㸧ࡪࠋࢥ࢜ࣟࢠ 㛫ࡢ㛫㝸ࡀ▷࠸᪉ࡀ㛗ᮇグ᠈ࡀᡂ❧ࡋࡸࡍࡃࠊࡇ ໝ࠸ࢆႥࡀࡏࡓ┤ᚋゐゅࡸཱྀỈࢆࡘࡅࡿࠊ ࡢཎ๎ࡀᙜ࡚ࡣࡲࡽ࡞࠸ࡇࡀศࡗࡓࠋࡉࡽ ໝ࠸ࢆႥࡀࡏࡓࡔࡅ࡛ MER ࢆ㉳ࡇࡍࡼ࠺࡞ࡗ ࢦ࢟ࣈ࡛ࣜࡣࠊ᮲௳ࡅヨ⾜ࢆඛ⾜ࡍࡿヨ⾜ࡢ㸯 ࡓࠋࡍ࡞ࢃࡕໝ࠸Ỉ㸦ሗ㓘㸧ࡢ᮲௳ࡅࡀᡂ❧ 㸮í㸯㸴ศᚋ⾜࠺ࠊ㛗ᮇグ᠈ࡢᙧᡂࡀᢚไࡉࢀ ࡋࡓࠋ ࡿࡇࡀศࡗࡓࠋࡇࡢᢚไ⌧㇟ࡀ㉳ࡇࡿ᮲௳ ࢥ࢜ࣟࢠࡢ MER ᮲௳ࡅࢆ⏝࠸࡚ࠊỈࢆ⏝࠸ࡓ ࡘ࠸࡚ゎᯒࡋࡓ⤖ᯝࠊ᮲௳ࡅヨ⾜ࡼࡗ࡚㛗ᮇ ሗ㓘Ꮫ⩦ཬࡧሷỈࢆ⏝࠸ࡓ⨩Ꮫ⩦㛵ࢃࡿ⚄⤒ఏ グ᠈ࢆᢚไࡍࡿ㐣⛬ಁ㐍ࡍࡿ㐣⛬ࡢ୧᪉ࡀᘬࡁ 㐩≀㉁ࡘ࠸࡚⸆⌮Ꮫⓗㄪࡓࠋ᮲௳ࡅカ⦎ ㉳ࡇࡉࢀࠊࡑࡢ┦స⏝ࡼࡾ㛗ᮇグ᠈ࡀᙧᡂࡉ ๓࢜ࢡࢺࣃ࣑ࣥཷᐜయ㜼ᐖࢆᢞࡋࡓࢥ࢜ࣟ ࢀࡿࡀỴࡲࡿࡇࡀ♧၀ࡉࢀࡓࠋࡇࢀࡽࡢ⤖ᯝ ࢠ࡛ࡣࠊ⨩Ꮫ⩦ࡣṇᖖᡂ❧ࡋࡓࡀሗ㓘Ꮫ⩦ࡣᡂ ࡣࠊࢦ࢟ࣈࣜࡀ㛗ᮇグ᠈ᙧᡂࡢ࣓࢝ࢽࢬ࣒ࡢ᭦࡞ ❧ࡋ࡞ࡗࡓࠋᏛ⩦カ⦎๓ࢻ࣮ࣃ࣑ࣥཷᐜయ㜼 ࡿゎᯒࡢࡓࡵࡢඃࢀࡓ◊✲ᮦᩱ࡞ࡾ࠺ࡿࡇࢆ ᐖࢆᢞࡋࡓࢥ࢜ࣟࢠ࡛ࡣࠊሗ㓘Ꮫ⩦ࡣṇᖖ࡛ ♧ࡋ࡚࠸ࡿࠋ ࠶ࡗࡓࡀ⨩Ꮫ⩦ࡢᡂ❧ࡋ࡞ࡗࡓࠋࡇࡢ⤖ᯝཬࡧ ᮏ◊✲ᐊ࡛ࡢᚑ᮶ࡢ◊✲⤖ᯝࢆ⥲ྜࡋࠊࢥ࢜ࣟࢠ ཎⴭㄽᩥ ࡢ᮲௳ࡅ࠾࠸࡚ࡣሗ㓘ሗࡣ࢜ࢡࢺࣃ࣑ࣥࢽ 1) Awata H, Watanabe T, Hamanaka Y, Mito T, Noji S, Mizunami M. (2015) Knockout crickets for the ࣮ࣗࣟࣥࡀࠊ⨩ሗࡣࢻ࣮ࣃ࣑ࣥࢽ࣮ࣗࣟࣥࡀ㐠 study of learning and memory: Dopamine receptor ࡪࡢ⤖ㄽࡀᚓࡽࢀࡓࠋࢩࣙ࢘ࢪࣙ࢘ࣂ࢚࡛ࡣሗ Dop1 mediates aversive but not appetitive 㓘ሗ⨩ሗࡢ୧᪉ࢆࢻ࣮ࣃ࣑ࣥࢽ࣮ࣗࣟࣥࡀ reinforcement in crickets. Sci. Rep. 5: 15885. 㐠ࡪࡇࡀ♧၀ࡉࢀ࡚࠾ࡾࠊ⚾ࡓࡕࡢ◊✲ᡂᯝࡣࠊ 2) Matsumoto Y, Matsumoto CS, Wakuda R, Ichihara ᪻ࡢ✀㛫࡛Ꮫ⩦ࡢᇶᮏ࣓࢝ࢽࢬ࣒ᕪ␗ࡀ࠶ࡿ S, Mizunami M. (2015) Roles of octopamine and ࡇࢆ♧ࡍࡶࡢ࡛࠶ࡿࠋࡑࡢࡼ࠺࡞ᕪ␗ࡀࡢࡼ dopamine in appetitive and aversive memory ࠺࡞㐍ⓗ࡞⌮⏤࡛⏕ࡌࡓࡢᴟࡵ࡚⯆῝࠸ࠋ acquisition studied in olfactory conditioning of maxillary palpi extension response in crickets. 㸰㸬 ࢥ࢜ࣟࢠࡢ♫Ꮫ⩦࠾ࡅࡿಶయㄆ▱ࡢឤ Front. Behav. Neurosci. 9:230. 3) Nishino H, Watanabe H, Kamimura I, Yokohari F, ぬᡭࡀࡾࡢゎ᫂ Mizunami M. (2015) Coarse topographic ࢥ࢜ࣟࢠࡣಶయࡢ⾜ືࢆほᐹࡍࡿࡇ࡛⮬ࡽ┤ organization of pheromone-sensitive afferents from ᥋⤒㦂ࡍࡿࡇ࡞ࡃᏛ⩦ࡍࡿ♫Ꮫ⩦ࡢ⬟ຊࢆᣢ different antennal surfaces in the American ࡘࠋᮏᖺᗘࡣࢥ࢜ࣟࢠࡢ♫Ꮫ⩦࠾࠸࡚ࠊࡢ cockroach. Neurosci. Lett. 595: 35-40. ࡼ࠺࡞ឤぬࡢᡭࡀࡾࡼࡾಶయࡢㄆ▱ࡀ࡞ࡉ 4) Terao K, Matsumoto Y, Mizunami M (2015) ࢀࡿࡢࡘ࠸࡚ㄪࡓࠋࡲࡎᬯ㯮࡛ࡢ♫Ꮫ Critical evidence for the prediction error theory in ⩦カ⦎࡛ࡶ♫Ꮫ⩦ࡣᡂ❧ࡋࡓࡇࡽࠊಶయ associative learning. Sci. Rep. 5: 8929. ࡢㄆ▱ᚲࡎࡋࡶどぬࡣᚲせ࡛ࡣ࡞࠸ࡇࡀศ ⴭ᭩ ࡗࡓࠋḟಶయࡽࡢႥぬࡢᡭࡀࡾࡀ࠼࡞ 1) ᯇᮏᖾஂࠊỈἼㄔࠊᯇᮏ༓ᑜ (2015)ࠕ᪻ ࠸᮲௳࡛♫Ꮫ⩦カ⦎ࢆ⾜ࡗࡓࡇࢁࠊࡇࡢ᮲௳ ໝ࠸ࢆぬ࠼ࡉࡏࡼ࠺ࠖ(ศᢸᇳ➹)ࠊ◊✲⪅ࡀᩍ ୗ࡛ࡶ♫Ꮫ⩦ࡀ㉳ࡇࡿࡇࡀศࡗࡓࠋࡇࢀࡽ ࠼ࡿື≀ᐇ㦂ࠊ➨㸱ᕳ ⾜ືࠊ⸛ᾈஅ⦅ࠊඹ ࡢ⤖ᯝࡽࠊ♫Ꮫ⩦࠾ࡅࡿಶయࡢㄆ▱ࡣ ❧ฟ∧, pp.182-187. どぬႥぬࡢ୧᪉ࡀ⏝࠸ࡽࢀࡿࡇࡀศࡗࡓࠋ 2) ỈἼㄔࠊ(2015) ࠕ⬻⏬ീ㞟ࠖ(ศᢸᇳ➹)ࠊ◊✲ ⏕≀⛉Ꮫ㒊㛛 ⾜ື⚄⤒⏕≀Ꮫศ㔝 ỈἼ ㄔ − 18 − ⪅ࡀᩍ࠼ࡿື≀ᐇ㦂 ➨ 2 ᕳ ⚄⤒࣭➽ࠊ⸛ᾈ அ⦅ࠊඹ❧ฟ∧ࠊpp192-197. ⥲ㄝ 1) Mizunami M, Hamanaka Y, Nishino H. (2015) Toward elucidating diversity of neural mechanisms underlying insect learning. Zool. Letters. 1:8 ⏕≀⛉Ꮫ㒊㛛 ⾜ື⚄⤒⏕≀Ꮫศ㔝 ᑠᕝ ᏹே ᖹᡂ 27 ᖺᗘ◊✲ᡂᯝ ୖグタ࡛㣫⫱ࡋࡓࣇࢱ࣍ࢩࢥ࢜ࣟࢠ㸦Gryllus bimaculatus㸧ࢆᮦᩱࡋ࡚㸪⚄⤒⏕≀Ꮫⓗᐇ㦂ࢆ ⾜࠸㸪௨ୗࡢࡼ࠺࡞◊✲ᡂᯝࢆᚓࡓࠋ ࢥ࢜ࣟࢠࡣ㸪⭡㒊ᮎ➃ࡢᑿⴥࡤࢀࡿᶵᲔឤ ぬჾᐁ࡛✵Ẽὶືࢆཷᐜࡋ㸪▷࠸Ẽὶ่⃭ᑐ ࡋ࡚⣲᪩ࡃ㐲ࡊࡿṌ⾜⾜ືࢆ♧ࡍࠋࡇࡢ⾜ືࡣ Ẽὶࢆᤕ㣗⪅ࡢ᥋㏆ᤊ࠼㸪ᤕ㣗ࡽ㏨ࢀࡼ࠺ ࡍࡿ㏨㑊⾜ື࡛࠶ࡿ⪃࠼ࡽࢀ࡚࠸ࡿࠋᡃࠎࡣࡇ ࢀࡲ࡛㸪ࢥ࢜ࣟࢠẼὶㄏᑟᛶṌ⾜㐠ືࡀ่⃭᪉ ྥ౫Ꮡⓗไᚚࡉࢀ࡚࠸ࡿࡇ㸪ࡑࡢไᚚ⬻ ࡽࡢୗ⾜ᛶࢽ࣮ࣗࣟࣥࡀ㛵ࡋ࡚࠸ࡿࡇࢆ᫂ࡽ ࡋࡓࠋ୍᪉㸪ࢥ࢜ࣟࢠࡣ๓⫥㰘⭷ჾᐁ ࡤࢀࡿ⫈ぬჾᐁࢆᣢࡘࠋࡇࢀࡼࡗ࡚ྠ✀ࡢ㬆ࡁ ḷࢆ᳨ฟࡋ࡚࠸ࡿ㸪ࢥ࢜ࣟࢠࢆ⿵㣗ࡍࡿࢥ࢘ ࣔࣜࡢ࢚ࢥࣟࢣ࣮ࢩࣙࣥࡢࡓࡵࡢ㡢Ἴࡶཷᐜࡋ࡚ ࠸ࡿ⪃࠼ࡽࢀ࡚࠸ࡿࠋࡋࡋ㸪⫈ぬẼὶឤぬ 㛫ࡢ┦స⏝ࡘ࠸࡚ࡣ㸪࠸ࡲࡔᮍゎ࡛᫂࠶ࡿࠋ ࡑࡇ࡛㸪Ẽὶ่⃭㸦200 ࣑ࣜ⛊ࡢ࢚ࣃࣇ㸧ඛ ⾜ࡋ࡚㡢่⃭㸦10 kHz ࢺ࣮ࣥ㡢㸧ࢆ࿊♧ࡋ㸪ࡑࢀ ⥆ࡃ࢚ࣃࣇࡼࡗ࡚㉳ࡇࡿṌ⾜⾜ືࡀኚࡍ ࡿࢆㄪࡓࠋ 㡢่⃭Ẽὶ่⃭ࡢ㛫ࡢ✵㛫㛵ಀࡀ㸪┦స ⏝ཬࡰࡍᙳ㡪ࢆ᳨ドࡍࡿࡓࡵ㸪ࡲࡎ✵㛫㛵ಀ ࡋ࡚୧่⃭ࢆྠ᪉ྥࡽ࠼ࡓሙྜ㸦match ⩌㸧 㸪 Ẽὶ่⃭᪉ྥࢃࡽࡎ㡢ࢆᖖ๓᪉ࡽ࠼ ࡓ⩌㸦mismatch ⩌㸧 㸪㡢่⃭ࢆ࠼࡞࠸⩌㸦tone free ⩌㸧ศࡅ㸪ࢺࣞࢵࢻ࣑ࣝୖ࡛ࡢẼὶ่⃭ᑐࡍ ࡿṌ⾜⾜ືࢆẚ㍑ࡋࡓࠋmatch ⩌㸪mismatch ⩌࠸ ࡎࢀࡶ㡢่⃭ࡣẼὶ่⃭ 800 ms ඛ⾜ࡋ࡚࿊♧ࡋ㸪 ྠ่⃭ࢆ⤊ࡉࡏࡓࠋࡑࡢ⤖ᯝ㸪㡢่⃭ࢆ ࠼ࡓ⩌࡛ࡣ㸪ഃ᪉ࡽࡢẼὶᑐࡍࡿṌ⾜᪉ྥࡀ ᚋ᪉೫ࡿࡇࡀศࡗࡓࠋࡲࡓ㸪ᵝࠎ࡞㏿ᗘࡢ Ẽὶ่⃭ࢆ࠼ࡓࡁࡢᛂ☜⋡ࢆẚ㍑ࡋࡓࡇ ࢁ㸪㡢่⃭ࢆ࠼ࡓሙྜ㸪่⃭ᙉᗘ౫Ꮡ᭤⥺ࡀྑ ഃࢩࣇࢺࡍࡿ㸪ࡍ࡞ࢃࡕᛂ㜈್ࡀୖ᪼ࡍࡿࡇ ࡀศࡗࡓࠋࡋࡋ㸪ࡕࡽࡢຠᯝࡶ match ⩌ mismatch ⩌ࡢ㛫࡛ࡣᕪࡀぢࡽࢀ࡞ࡗࡓࡇ ࡽ㸪ࡇࡢ⫈ぬධຊࡼࡿẼὶㄏᑟᛶṌ⾜ࡢಟ㣭 ࡣ୧ࣔࢲࣜࢸࡢ่⃭㛫ࡢ✵㛫ሗࡢ୍⮴ᛶࡣ㛵 ࡋ࡞࠸ᛮࢃࢀࡿࠋ ḟ㸪㡢่⃭Ẽὶ่⃭㛫ࡢ㛫ⓗ㛵ಀࡢᙳ㡪 ࢆㄪࡿࡓࡵ㸪㡢่⃭ࡢ㛤ጞࢆẼὶ่⃭㛤ጞࡼࡾ ࡶ 800㸪200㸪0 ms ඛ⾜ࡉࡏࡓ⩌㸦࠸ࡎࢀࡶ㡢ࡣẼ ὶ่⃭ྠ⤊㸧㛫㸪㡢่⃭ࡢ⤊㛫ࢆ Ẽὶ่⃭⤊ࡼࡾ 600㸪200㸪0 ms ඛ⾜ࡉࡏࡓ⩌ 㸦࠸ࡎࢀࡶ㡢ࡣẼὶ่⃭ 800 ms ඛ⾜ࡉࡏ࡚㛤 ጞ㸧㛫࡛ẚ㍑ࡋࡓࠋࡑࡢ⤖ᯝ㸪๓⪅ࡢ⩌㛫࡛ࡣ㸪 㡢่⃭ࢆඛ⾜ࡉࡏࡓ⩌㸦800 ࠾ࡼࡧ 200 ms㸧࡛ࡣ Ṍ⾜᪉ྥࡣᚋ᪉೫ࡗࡓࡀ㸪ྠ㛤ጞࡋࡓ⩌㸦0 ms㸧࡛ࡣ tone free ኚࢃࡽ࡞ࡗࡓࠋࡍ࡞ࢃࡕ㸪 ⫈ぬධຊࡼࡿṌ⾜᪉ྥࡢಟ㣭ࡣ㸪㡢่⃭ࡢඛ ⾜ࡀᚲせ࡛࠶ࡿ⪃࠼ࡽࢀࡿࠋ୍᪉㸪㡢่⃭ࢆ࿊ ♧ࡋࡓ⩌ࡣ㸪ඛ⾜㛫ࢃࡽࡎᛂ㜈್ࡢୖ ᪼ࡀぢࡽࢀࡓࠋࡋࡓࡀࡗ࡚㸪⫈ぬධຊࡼࡿᛂ 㜈್ࡢಟ㣭ࡣ㸪Ṍ⾜᪉ྥࢆኚࡉࡏࡿࡢࡣ␗࡞ ࡿ⚄⤒ᶵᵓࡼࡿࡶࡢ࡛࠶ࡿྍ⬟ᛶࡀ࠶ࡿࠋḟ㸪 ่⃭⤊้ࢆࢩࣇࢺࡉࡏࡓ⩌㛫࡛ࡣ㸪⤊㛫 ࢃࡽࡎṌ⾜᪉ྥࡢᚋ᪉ࡢ೫ࡾᛂ㜈್ ࡢୖ᪼ࡀࡳࡽࢀࡓࠋࡍ࡞ࢃࡕ㸪㡢่⃭ࡼࡿẼὶ ㄏᑟᛶṌ⾜ࡢಟ㣭ࡣ㸪⫈ぬẼὶឤぬࡢྠධຊ ࡣᚲせࡋ࡞࠸ࡇࡀ♧၀ࡉࢀࡓࠋ௨ୖࡢ⤖ᯝ ࡽ㸪ࢥ࢜ࣟࢠࡣ⫈ぬࡼࡗ࡚␗࡞ࡿ≧ἣࢆㄆ㆑ࡋ㸪 ࡑࢀ㐺ᛂࡋ࡚Ẽὶ㏨㑊⾜ືࢆኚࡉࡏ࡚࠸ࡿࡇ ࡀ♧၀ࡉࢀࡓࠋ Ⓨ⾲ㄽᩥ 1) Fukutomi, M., Someya, M. and Ogawa, H. (2015) Auditory modulation of wind-elicited walking behavior in the cricket, Gryllus bimaculatus. Journal of Experimental Biology. Exp. Biol., 218:3968-3977. 2) Ogawa, H. and Mitani, R. (2015) Spatial dynamics of action potentials estimated by dendritic Ca2+ signals in insect projection neurons. Biochemical and Biophysical Research Communications, 467:185-190. 3) Ogawa, H. and Oka, K. (2015) Direction-specific adaptation in neuronal and behavioral responses of an insect mechanosensory system. The Journal of Neuroscience, 35:11644-11655. ᅜ㝿㆟Ⓨ⾲ 1㸧 Ogawa, H., Mitani, R., and Oka, K. (2015) Direction-specific adaptation in neuronal and behavioral responses of cercal sensory system in the cricket. 45th Annual Meeting of Society for Neuroscience, McCormick Place㸦Chicago㸧 2㸧 Fukutomi, M. and Ogawa, H. (2015) Preceding auditory inputs modulate responsiveness and orientation in wind-elicited walking behavior in − 19 − the cricket. 45th Annual Meeting of Society for Neuroscience, McCormick Place㸦Chicago㸧 3㸧 Ogawa, H. and Fukutomi, M.㸦2015㸧 Temporal relationships between multisensory stimuli have modulatory effects on escape behavior in the crickets. International Symposium on the Science of Mental Time, ᮾிᕤᴗᏛ࢟ࣕࣥࣃࢫࣀ࣮࣋ࢩࣙࣥ ࢭࣥࢱ࣮㸦ᮾி㒔㸧 ᅜෆᏛⓎ⾲ 1㸧 ⚟ᐩཪ୕㑻㸪ᑠ ᑠᕝᏹே㸦2015㸧 ඛ⾜ࡍࡿ㡢่⃭ࡣࢥ࢜ࣟࢠࡢẼὶ㏨㑊⾜ືࢆಟ 㣭ࡍࡿ ᪥ᮏື≀Ꮫ➨ 86 ᅇ㸪ᮒ㮛࣓ࢵࢭ㸦᪂₲ᕷ㸧 2㸧 ᑠᕝᏹே㸪୕㇂⍠㔛Ꮚ㸦2015㸧 ᶵᲔឤぬᛶᢞᑕࢽ࣮ࣗࣟࣥᶞ≧✺㉳࡛ࡢ᪉ྥ㑅 ᢥᛶᙧᡂ㐣⛬ᑐࡍࡿ GABA సືᛶᢚไᛶධຊ ࡢຠᯝ Neuroscience 2015—➨ 38 ᅇ᪥ᮏ⚄⤒⛉Ꮫ—㸪 ⚄ᡞᅜ㝿㆟ሙ㸦⚄ᡞᕷ㸧 3㸧 ⚟ᐩཪ୕㑻㸪ᑠ ᑠᕝᏹே㸦2015㸧 ඛ⾜ࡍࡿ㡢่⃭ࡣࢥ࢜ࣟࢠࡢẼὶㄏᑟᛶ㏨㑊⾜ ືࢆಟ㣭ࡍࡿ Neuroscience 2015—➨ 38 ᅇ᪥ᮏ⚄⤒⛉Ꮫ—㸪 ⚄ᡞᅜ㝿㆟ሙ㸦⚄ᡞᕷ㸧 ࢡ࣮ࣟࣥࠊGfp ࡲࡓࡣ Luciferase 㑇ఏᏊࢆ⤌ࡳ㎸ ࢇࡔࢺࣛࣥࢫࢪ࢙ࢽࢵࢡ࣐࢘ࢫࢆసฟࡋ࡚ࠊ⚄⤒ ⣔Ⓨ⌧ᐤࡍࡿࢩࢫ㡿ᇦࠊᮇ≉␗ⓗⓎ⌧ᐤ ࡍࡿࢩࢫ㡿ᇦࡘ࠸࡚ࠊ2 ࡘࡢ BAC ࡢඹ㏻㡿ᇦ 64.0kbp ࢆࢩࢫ㡿ᇦࡋ࡚࣐ࢵࣆࣥࢢࡋ࡚࠸ࡓࡀࠊ ᖺᗘࡣࣉ࣮ࣟࣔࢱ࣮ࢺࣛࣥࢫࢪ࢙ࢿࢩࢫࡼࡾ 0.6kbp ࡢୖὶ㡿ᇦ࡛ࡣ Ntn4 㑇ఏᏊࡢⓎ⌧ࡣ ࡛ࠊୖὶ 3.7kbp ࡢ㡿ᇦ࡞ࡽ࡞ࡀࡽ Ntn4 㑇ఏᏊࡢ⚄⤒⣔Ⓨ⌧ࠊᮇ≉␗ⓗⓎ⌧ࡀぢࡽࢀࡿ ࡇࠊH3K27Ac ࡢ ChIP-seq ゎᯒࡢ࣓ࢱゎᯒࡼࡾࠊ 2 ࡘࡢ BAC ࡢඹ㏻㡿ᇦ 64.0kbp ෆ࡛࢚ࣥࣁࣥࢧ࣮ 㡿ᇦࡋ࡚ 1kb ๓ᚋࡢ㡿ᇦೃ⿵ࡀ⤠ࡾ㎸ࡵࡿࡇ ࡀ᫂ࡽ࡞ࡗࡓࠋᚋࡣࠊࡇࡢ 1kb ๓ᚋࡢ㡿 ᇦࢆḞኻࡉࡏ࡚ࢩࢫ㡿ᇦ࡛࠶ࡿࡇࢆ♧ࡍࡶ ࠊ⾲⌧ᆺኚࡀ⏕ࡌࡿྰࡢ᳨ウࢆ⾜࠺ィ ⏬࡛࠶ࡿࠋ ⏕≀⛉Ꮫ㒊㛛 ⾜ື⚄⤒⏕≀Ꮫศ㔝 ከ ᏹ ◊✲⤖ᯝ 㡢ኌⓎኌᏛ⩦ࡢ⮫⏺ᮇไᚚཬࡧࠊ✀≉␗ⓗ࡞Ⓨ ኌࣃࢱ࣮ࣥ⏕ᡂ㛵ࢃࡿ㑇ఏᏊ⩌ࢆ᫂ࡽࡋࠊ ࡑࡢ⬻ෆศᏊᶵ⬟ࢆ⚄⤒⾜ືᏛⓗ᳨ドࡍࡿࡇ ࢆ┠ⓗࡋ࡚◊✲ࢆ㐍ࡵ࡚࠸ࡿࠋࡑࡢࡓࡵື≀ ࣔࢹࣝࡋ࡚㬆⚺㢮ࢯࣥࢢࣂ࣮ࢻࢆ⏝࠸ࡓ◊✲ࢆ ⾜ࡋ࡚࠸ࡿࠋࣄࢺゝㄒ⋓ᚓࡶ㬆⚺㢮ࡢⓎኌᏛ⩦ ࡶឤぬ㐠ືᏛ⩦ࢆ᰿ᖿࡍࡿࠋ⮬ࡽኌࢆฟࡋࠊࡇ ⏕≀⛉Ꮫ㒊㛛 ⾜ື⚄⤒⏕≀Ꮫศ㔝 ࢀࢆ⧞ࡾ㏉ࡍࡇ࡛グ᠈ࡋࡓ㡢ኌࣃࢱ࣮ࣥಟṇ ⏣ ୍༤ ࡋ࡚࠸ࡃࠋࡇࡢ㡢ኌⓎኌᏛ⩦ࡣࠊᏛ⩦ࡢࡓࡵ ᭱ࡶ㐺ࡋࡓᮇࠊᏛ⩦⮫⏺(㐺ᛂ)ᮇࡀᏑᅾࡍࡿࠋ⚄ ⏕ᚋⓎ㐩ᮇࡢ⬻⓶㉁࡛ࡣࠊྛ✀่⃭ࡼࡿ⚄ ⤒⛉Ꮫศ㔝࠾࠸࡚ࠊ ࠗ⮫⏺ᮇࢆഛ࠼ࡿឤぬ㐠ືᏛ ⤒άືࡀ⚄⤒ᅇ㊰ᙧᡂ㔜せ࡞ᙺࢆᯝࡓࡋ࡚࠸ ⩦࠘ࡢ⌮ゎࡣศᏊ࡛ࣞ࣋ࣝࡶࠊ⾜ື࡛ࣞ࣋ࣝࡶࡇ ࡿࡀࠊࡑࡢᇶ♏ⓗ࡞ศᏊ࣓࢝ࢽࢬ࣒ࡢゎ᫂ࡣᮍࡔ ࢀࡲ࡛༑ศ㐍ࢇ࡛࠸࡞࠸ࠋࡲࡓࠊ࠸ࡋ࡚ ༑ศ࡛࠶ࡿࠋᡃࠎࡣ Ntn4 (Netrin-4)㑇ఏᏊ╔┠ Ꮫ⩦㐣⛬ࢆ⤒ࡿ࡞࡛✀≉␗ⓗ࡞⾜ືᙧᡂࡀ࡞ࡉ ࡋࠊࡑࡢᤄධ✺↛ኚ␗ࣛࢵࢺࢆ⏝࠸ࡓ㜰Ꮫࡢ ࢀࡿࡢࠊ᫂ࡢࡲࡲ࡛࠶ࡿࠋ ᒣᮏᩍᤵࡽࡢඹྠ◊✲ࢆ㏻ࡌ࡚ࠊ㸦㸯㸧Ntn4 㑇 ࡇࢀࡲ࡛ࠊ㡢ኌⓎኌᏛ⩦࠾࠸࡚ࠕኌࢆฟࡍࠖ ఏᏊࡣ㍈⣴ࡢᯞศࢀࢆಁ㐍ࡍࡿᶵ⬟ࢆࡶࡘࡇࠊ ࠸࠺⮬Ⓨⓗ⾜ືࡀࠊ⬻ෆศᏊࣞ࣋ࣝ࠾࠸࡚ࡶ 㸦㸰㸧Ntn4 㑇ఏᏊࡣࠊ⬻⓶㉁࡛ᒙ≉␗ⓗࠊ⏕ 㔜せ࡞ពࢆࡶࡘ⪃࠼ࠊࢯࣥࢢࣂ࣮ࢻࡢⓎኌ⾜ ᚋⓎ㐩ᮇ≉␗ⓗࠊ⚄⤒άື౫ᏑⓗⓎ⌧ࡍࡿࡇ ືࡼࡾⓎ⌧ㄏᑟࡉࢀࡿ㑇ఏᏊ⩌ࡢྠᐃࢆヨࡳ࡚ ࠊࢆ♧ࡋ࡚ࡁࡓࠋࡇࢀࡽࡢ⤖ᯝࡣࠊNtn4 㑇ఏᏊ ࡁࡓࠋࡑࡢ⤖ᯝࠊ[Ⓨኌ⾜ື౫Ꮡᛶ]㸩[⚄⤒ᅇ㊰≉ ࡀ⬻⓶㉁ࡢ⏕ᚋⓎ㐩㔜せ࡞ᙺࢆ₇ࡌ࡚࠸ࡿ ␗ᛶ]㸩[Ꮫ⩦⮫⏺ᮇ㛫㝈ᐃᛶ]ࢆවࡡഛ࠼ࡓከẁ㝵 ࡇࢆ♧၀ࡍࡿࠋᖺᗘᘬࡁ⥆ࡁࠊࣉ࣮ࣟࣔࢱ Ⓨ⌧ไᚚࢆཷࡅࡿ㑇ఏᏊ⩌ࡀᏑᅾࡍࡿࡇࢆ᫂ࡽ ࣮ࢺࣛࣥࢫࢪ࢙ࢿࢩࢫ࠾ࡼࡧ BAC ࢺࣛࣥࢫࢪ࢙ ࡋ࡚ࡁࡓࠋࡲࡓࠊࡇࢀࡽከẁ㝵Ⓨ⌧ไᚚࢆཷ ࢿࢩࢫࡼࡾࠊNtn4 㑇ఏᏊࡢᮇࠊ㒊ࠊ⚄⤒ά ࡅࡿ㑇ఏᏊ⩌ࡢ࡞࢚ࣆࢪ࢙ࢿࢸࢡࢫไᚚ㛵 ື౫Ꮡⓗ࡞Ⓨ⌧ࢆㄪ⠇ࡍࡿศᏊ࣓࢝ࢽࢬ࣒ࡢゎ᫂ 㐃ᅉᏊࡀᏑᅾࡍࡿࡇ╔┠ࡋࠊࡇࢀࡽ㑇ఏᏊ⩌ ࢆ┠ᣦࡋࠊࢩࢫ㡿ᇦࡢ≉ᐃࢆヨࡳࡓࠋ ࡢⓎ㐩ẁ㝵࣭⎔ቃ༶ࡋࡓከẁ㝵(✵㛫)ไᚚࡇࡑ ᖺᗘࡲ࡛ BAC ࢚ࣥࢪࢽࣜࣥࢢࡼࡾࠊ㌿ ࡀ⮬Ⓨⓗ⾜ືࡼࡗ࡚⋓ᚓࡉࢀࡿᏛ⩦ࡢศᏊᇶ┙ 㛤ጞⅬࡢୖὶ 65.7kbp ࡽ㌿⤊⤖Ⅼࡢୗὶ ࡞ࡾ࠼ࡿࡢ࡛ࡣ࡞࠸⪃࠼ࠊᖹᡂ 27 ᖺᗘ࠾ 27.5kbp ࢆྵࡴ BACࠊ㌿㛤ጞⅬࡢୖὶ 177.5kbp ࠸࡚ࡶᘬࡁ⥆ࡁࠊ࢘ࣝࢫⓎ⌧⣔ࢆ⏝࠸ࡓேⅭⓗ ࡽୗὶ 1.7kb ࢆྵࡴ BAC ࡢ࠶ࢃࡏ࡚㸰ࡘࡢ BAC − 20 − 㑇ఏᏊⓎ⌧ᨵኚᢏ⾡ࢆ⏝࠸ࠊ⌧ᅾ◊✲ࢆ㐍ࡵ࡚࠸ ࡿࠋ ㄽᩥⓎ⾲ z Ohgushi E, Mori C, Wada K. Diurnal oscillation of vocal development associated with clustered singing by juvenile songbirds. Journal of Experimental Biology 218: 2260-2268. 2015 z Mori C, Wada K Audition-Independent Vocal Crystallization Associated with Intrinsic Developmental Gene Expression Dynamics. Journal of Neuroscience 35:878-889. 2015 ᏛⓎ⾲ z ᳃༓⣫ࠊከᏹ ࠗAudition-Independent Vocal Crystallization Associated with Intrinsic Developmental Gene Expression Dynamics ⫈ぬ ౫Ꮡࡋ࡞࠸Ⓨኌࣃࢱ࣮ࣥᅛᐃࡢ࣓࢝ࢽࢬ ࣒ࠖ ࠘➨ 38 ᅇ᪥ᮏ⚄⤒⛉Ꮫᖺ 2015 ᖺ 7 ᭶ 28 ᪥㸦⚄ᡞ ⚄ᡞࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮㸧 z Sato D, Wada K ࠗFamilial genetic bias in vocal babbling pattern at early song development ࠘ Society for Neuroscience meeting 2015, October 18 (USA, Chicago, McCormick Place) z ⃝ᱻࠊከᏹࠗ㬆⚺㢮㞧✀ࡢḷᏛ⩦ࡢ ಶయᕪ࠼ࡿᏛ⩦ࣂࢫ࠘ ᪥ᮏື≀⾜ືᏛ 2015 ᖺ 11 ᭶ 20 ᪥(ᮾி࣭ ᮾிᾏὒᏛ㸧 ⏕≀⛉Ꮫ㒊㛛 ⏕ṪⓎ⏕⏕≀Ꮫศ㔝 ᒣୗ ṇව ⬨᳝ື≀࠾ࡅࡿ⏕Ṫ⣽⬊ᙧᡂࡢไᚚᶵᵓ 㸯㸬ࢮࣈࣛࣇࢵࢩࣗ༸ẕ⣽⬊࠾ࡅࡿࢧࢡࣜ ࣥ B1 mRNA ࡢᚤ⣽ᵓ㐀ࡢほᐹ㸦ఀ⸨ⲁࠊຍ⸨㯞 ዉ㸧 ࣄࢺࢆྵࡴከࡃࡢ⬨᳝ື≀࠾࠸࡚ࠊῶᩘศ ➨୍๓ᮇࡢᮍᡂ⇍༸ࡣ༸ᡂ⇍ㄏ㉳࣍ࣝࣔࣥࡢ่⃭ ࢆཷࡅ࡚➨୰ᮇ㐩ࡋࠊཷ⢭ྍ⬟࡞ᡂ⇍༸࡞ ࡿࠋࡇࡢ㐣⛬ࡣ༸ᡂ⇍ࡤࢀࠊ༸ࡀཷ⢭⬟ࢆ⋓ ᚓࡍࡿ㔜せ࡞㐣⛬࡛࠶ࡿࠋࢮࣈࣛࣇࢵࢩࣗᮍᡂ ⇍༸୰࡛ࠊࢧࢡࣜࣥ B1 mRNA ࡣື≀ᴟ┤ୗࡢ ⣽⬊㉁⩻ヂࢆᢚไࡉࢀࡓ≧ែ࡛ᒁᅾࡍࡿࠋ⩻ヂ ࡢᢚไࡣᵝࠎ࡞⩻ヂไᚚࢱࣥࣃࢡ㉁ࡀ⤖ྜࡋࠊ “㢛⢏”ࢆᙧᡂࡍࡿࡇࡀ㔜せ࡛࠶ࡾࠊ่࣍ࣝࣔࣥ ⃭ᛂ⟅ࡋ࡚“㢛⢏”ࡀᔂቯࡋࠊ⩻ヂࡀ㛤ጞࡉࢀࡿࠋ ྜᡂࡉࢀࡓࢧࢡࣜࣥ B1 ࢱࣥࣃࢡ㉁ࡣ Cdc2 ⤖ ྜࡋ࡚༸ᡂ⇍ಁ㐍ᅉᏊࢆᵓᡂࡋࠊࡇࢀࡀ༸ᡂ⇍ࡢ 㐍⾜୰ᚰⓗ࡞ᙺࢆᢸ࠺ࠋࡇࡢᶵᵓࡣ⬨᳝ື≀ ୍⯡ⓗ࡛࠶ࡾࠊࢧࢡࣜࣥ B1 ࡢ⩻ヂࡢࢱ࣑ࣥ ࢢሙᡤࡢཝᐦ࡞ไᚚࡀࠊṇᖖ࡞༸ᡂ⇍୪ࡧῶ ᩘศࡢ㐍⾜ྍḞ࡛࠶ࡿࠋ “㢛⢏”ࡢᚤ⣽ᵓ㐀ࢆ᫂ࡽࡍࡿࡓࡵࠊࢮࣈࣛ ࣇࢵࢩࣗᮍᡂ⇍༸ࡢ㉸ⷧษ∦ᑐࡋ࡚ in situ ࣁ ࣈࣜࢲࢮ࣮ࢩࣙࣥࢆ⾜࠸ࠊ㏱㐣ᆺ㟁Ꮚ㢧ᚤ㙾 ࡛ほᐹࡋࡓࠋࡑࡢ⤖ᯝࠊࢧࢡࣜࣥ B1 mRNA ࡣ ┤ᚄ 100 μm ⛬ᗘࡢᑠࡉ࡞จ㞟య࡞ࡗ࡚࠸ࡿࡇ ࡀ♧ࡉࢀࡓࠋࡇࡢᑠࡉ࡞จ㞟యࡀ」ᩘ㞟ྜࡍࡿ ࡇࡼࡾࠊ“㢛⢏”ࡀᙧᡂࡉࢀ࡚࠸ࡿ⪃࠼ࡽࢀ ࡿࠋࡲࡓࠊࢧࢡࣜࣥ B1 mRNA ⤖ྜࡍࡿࢱࣥ ࣃࢡ㉁ࡣจ㞟యࡢእഃ⨨ࡍࡿࡇࡀ᫂ࡽ ࡞ࡗࡓࠋᚋࠊ༸ᙧᡂ㐣⛬࠾ࡅࡿ“㢛⢏”ࡢᵓ㐀 ኚࢆㄪࡿࡓࡵࠊᵝࠎ࡞ࢫࢸ࣮ࢪࡢ༸ẕ⣽⬊ ࠾ࡅࡿࢧࢡࣜࣥ B1 mRNA ࡢᵓ㐀ࢆྠᵝࡢᢏ⾡ ࢆ⏝࠸࡚ほᐹࡍࡿணᐃ࡛࠶ࡿࠋ 㸰㸬ࢮࣈࣛࣇࢵࢩࣗ༸ẕ⣽⬊࠾ࡅࡿࢧࢡࣜ ࣥ B1 mRNA ࡢື≀ᴟࡢ㍺㏦⩻ヂไᚚᶵᵓࡢ ゎᯒ㸦㧗ᶫ୍ᶞࠊ▼㤶ዉ㸧 ࢩࣙ⢾ᐦᗘ໙㓄㉸㐲ᚰἲඹචỿ㝆ἲࢆ⏝࠸ࠊ ᪂ወࡢ⩻ヂไᚚࢱࣥࣃࢡ㉁ࡢྠᐃࢆヨࡳࡓࠋᚓࡽ ࢀ ࡓ ೃ ⿵ ࢱ ࣥ ࣃ ࢡ ㉁ ࡢ ࠺ ࡕ insulin-like growth factor 2 mRNA-binding protein 3 (IMP3) ࡣࠊ1㸧ᮍᡂ ⇍༸࠾࠸࡚ࢧࢡࣜࣥ B1 mRNA ྠᵝື≀ ᴟ┤ୗࡢ⣽⬊㉁ᒁᅾࡍࡿࠊ2㸧ᮍᡂ⇍༸࠾࠸࡚ ࢧࢡࣜࣥ B1 mRNA ≉␗ⓗ⤖ྜࡋ࡚࠸ࡿࠊ 3㸧 ᡂ⇍༸࡛ࡣࢧࢡࣜࣥ B1 mRNA ⤖ྜࡋ࡚࠸࡞ ࠸ࡇࡀศࡗࡓࠋࡲࡓࠊIMP3 ࡢᙉไⓎ⌧ࡼࡾ ࢧࢡࣜࣥ B1 mRNA ࡢ⩻ヂࡀ㐜ࢀࡓࡇࡽࠊ IMP3 ࡣᮍᡂ⇍༸࠾࠸࡚ࢧࢡࣜࣥ B1 mRNA ࡢ ⩻ヂࢆᢚไࡋ࡚࠸ࡿ⪃࠼ࡽࢀࡿࠋ ࢮࣈࣛࣇࢵࢩࣗ༸ẕ⣽⬊࠾࠸࡚ࢧࢡࣜࣥ B1 mRNA ࡣ༸ࡢື≀ᴟᒁᅾࡋ࡚࠸ࡿࡀࠊࡑࡢ㍺ ㏦ࡢศᏊ࣓࢝ࢽࢬ࣒ࡣ࡛᫂࠶ࡿࠋࡑࡇ࡛ࠊࣇ ࣜ࢝ࢶ࣓࢚࢞ࣝ༸ẕ⣽⬊࠾࠸࡚ࠊStaufen1 ࡀ IMP3 ༠ാࡋ࡚ mRNA ࡢ㍺㏦ࢆᢸࡗ࡚࠸ࡿ࠸ ࠺ඛ⾜◊✲╔┠ࡋࠊࢮࣈࣛࣇࢵࢩࣗ Staufen1 ᑐࡍࡿᢠయࢆస〇ࡋࠊゎᯒࡋࡓࠋࡑࡢ⤖ᯝࠊ Staufen1 ࡣࢧࢡࣜࣥ B1 mRNA ⤖ྜࡋࠊ༸ẕ⣽ ⬊ෆ࡛ඹᒁᅾࡋ࡚࠸ࡿࡇࡀศࡗࡓࠋࣇࣜ࢝ ࢶ࣓࢚࢞ࣝ༸ẕ⣽⬊࠾࠸࡚ࠊIMP3 Staufen1 ࡣ Vg1 mRNA ࡶ༸ࡢ᳜≀ᴟᒁᅾࡋ࡚࠾ࡾࠊ ࡑࡢ㍺㏦ᶵᵓࡣ Late Pathway ࡤࢀ࡚࠸ࡿࠋ୍ ᪉ࠊࢮࣈࣛࣇࢵࢩࣗ༸ẕ⣽⬊࠾࠸࡚ࠊVg1 mRNAࠊࢧࢡࣜࣥ B1 mRNAࠊIMP3ࠊStaufen1 ࡣࠊ ࠸ࡎࢀࡶື≀ᴟᒁᅾࡋ࡚࠸ࡿࡇࡀࠊᮏ◊✲࡛ ᫂ࡽ࡞ࡗࡓࠋࡇࢀࡽࡢᐇࡣࠊࢮࣈࣛࣇࢵ ࢩࣗ༸ẕ⣽⬊࠾ࡅࡿࢧࢡࣜࣥ B1 mRNA ࡢ㍺ ㏦⤒㊰ࡣࣇࣜ࢝ࢶ࣓࢚࢞ࣝ༸ẕ⣽⬊࠾ࡅࡿ Late Pathway 㢮ఝࡋࡓ࣓࢝ࢽࢬ࣒࡛࠶ࡿࡇࢆ − 21 − ♧၀ࡍࡿࠋ ㄽᩥⓎ⾲ Nakatsuma, A., Kaneda, M., Kodama, H., Morikawa, M., Watabe, S., Nakaishi, K., Yamashita, M., Yoshimura, T., Miura, T., Ninomiya M., and Ito E. (2015) Detection of HIV-1 p24 at attomole level by ultrasensitive ELISA with thio-NAD cycling. PLoS ONE 10(6): e0131319 Nukada, Y., Horie, M., Fukui, A., Kotani, T., and Yamashita, M. (2015) Real-time imaging of actin filaments in the zebrafish oocyte and embryo. Cytoskeleton, 72 (9): 491-501. Ito, E., Kaneda, M., Kodama, H., Morikawa, M., Tai, T., Aoki, K., Watabe, A., Nakaishi, K., Hashida, S., Tada, S., Kuroda, N., Imachi, H., Murao, K., Yamashita, M., Yoshimura, T., and Miura, T. (2015) Immunoreactive insulin in DM-patient sera detected by ultrasensitive ELISA with thio-NAD cycling. BioTechniques, 59 (December): 359-367. Nakatsuma, A., Kaneda, M., Kodama, H., Morikawa, M., Watabe, S., Nakaishi, K., Yamashita, M., Yoshimura, T., Miura, T., Ninomiya, M., and Ito, E. (2015) Ultrasensitive colorimetric detection of HIV-1 p24. Clinical Laboratory International, (2015) October Issue, 20-25. Shimizu, T., Karino, T., Narita, M., Itakura, S., Kawasaki, T., Takabatake, S., Iwai, T., and Yamashita, M. (2015) Establishment of the immunostaining method useful for investigating the distribution of Japanese scallop (Mizuhopecten yessoensis) larvae in the field. Scientific Reports of Hokkaido Fisheries Research Institutes, 88: in press [In Japanese with English abstract] ᏛⓎ⾲ 㧗ᶫ ୍ᶞ㸪▼ 㤶ዉ㸪ᒣୗ ṇව ࢮࣈࣛࣇࢵࢩࣗ༸ẕ⣽⬊࠾ࡅࡿࢧࢡࣜࣥ B1 mRNA ࡢᒁᅾ⩻ヂไᚚ Localization and translational regulation of cyclin B1 mRNA in zebrafish oocytes ➨ 38 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ/➨ 88 ᅇ᪥ᮏ⏕Ꮫ ྜྠ 2015 ᖺ 12 ᭶ 1-4 ᪥㸦⚄ᡞᕷ㸧 㸦࣏ ࢫࢱ࣮Ⓨ⾲㸧 㧗ᶫ ୍ᶞࠊᒣୗ ṇව ࢮࣈࣛࣇࢵࢩࣗ༸ᡂ⇍㐣⛬࠾ࡅࡿࢧࢡࣜࣥ B1 mRNA ࡢ⩻ヂไᚚ: IMP3 ࡢᣲືᶵ⬟ ᪥ᮏື≀Ꮫᾏ㐨ᨭ㒊➨ 60 ᅇ 2015 ᖺ 8 ᭶ 21 ᪥㸦ᮐᖠᕷ㸧 㸦ཱྀ㢌Ⓨ⾲㸧ඃ⚽Ⓨ⾲㈹ཷ㈹ 㧗ᶫ ୍ᶞࠊᒣୗ ṇව ࢮࣈࣛࣇࢵࢩࣗ༸ᡂ⇍㐣⛬࠾ࡅࡿࢧࢡࣜࣥ B1 mRNA ࡢ⩻ヂไᚚ ➨ 17 ᅇ᪥ᮏ RNA Ꮫ 2015 ᖺ 7 ᭶ 15-17 ᪥㸦ᮐᖠ ᕷ㸧 㸦࣏ࢫࢱ࣮Ⓨ⾲㸧 ⏕≀⛉Ꮫ㒊㛛 ⏕ṪⓎ⏕⏕≀Ꮫศ㔝 ΎỈ 㝯 [ࢺ࣑࣑ࢬ⬇ 2d ⌫ࡢศࣃࢱ࣮ࣥࡢゎᯒ] ࢺ࣑࣑ࢬ㸦Tubifex tubifex㸧ࡢ 2d ⌫㸦D ⣔ิ ࡢ➨ᑠ⌫㸧ࡣㄌ⏕ᚋ㸱ᅇࡢ➼ศࢆ⤒ࡓ࠶ ➼ศࡋ୍࡚ᑐࡢ NOPQ ⣽⬊㸦እ⬇ⴥᛶ➃⣽⬊ ࡢ๓㥑⣽⬊㸧ࢆᙧᡂࡍࡿࠋࡇࡢ㸱ᅇࡢ➼ศࡣࠊ ࡑࡢྥࡁࡀ㸦⬇๓᪉ࢆୖࡍࡿ㸧㡰㸲ࠊ㸶 ࠊ12 ࡢ᪉ྥ࡞ࡿࠋⓎ⏕ึᮇࡢࢺ࣑࣑ࢬ⬇ ࡢ୰ᚰయ㸦centrosome㸧ࡣศ⤊ᮇࡢẁ㝵࡛ࡍ࡛ 」〇ࡋ࡚࠸ࡿࡇࡀ▱ࡽࢀ࡚࠸ࡿࠋ୰ᚰయࡢ」〇 ᪉ྥ㸦㍈㸧ࡀ㐍⾜୰ࡢศࡢ㍈┤ࡍࡿ௬ᐃ ࡍࡿࠊࡇࡢ୰ᚰయࡢ」〇᪉ྥࡣḟࡢ➼ศࡢ ᪉ྥ㸦㍈㸧ࡰᖹ⾜࡞ࡿࡇࡀࢃࡿࠋࡇࡢ ௬ㄝࢆ᳨ドࡍࡿࡓࡵࠊᅇࡣ➼ศࡢ᪉ྥ ୰ᚰయࡢ」〇᪉ྥࡢ㛫┦㛵ࡀ࠶ࡿ࠺ࢆ ㄪࡓࠋ」〇┤ᚋࡢ୰ᚰయࢆᢠȚtubulin ᢠయ᳨࡛ ฟࡋࠊ୰ᚰయࡢ」〇㍈⣽⬊ศࡢ㍈ࡢᡂࡍゅ ᗘࢆ ᐃࡋࡓࠋࡑࡢ⤖ᯝࠊ୰ᚰయࡢ」〇㍈ḟᅇ ࡢ⣽⬊ศࡢ㍈ࡢ㛫┦㛵ࡣぢࡽࢀ࡞ࡗࡓࠋ ࡋࡓࡀࡗ࡚ࠊ2d ⌫ࡢ➼ศࡢྥࡁࡀỴࡲࡿ ⤌ࡳ୰ᚰయࡢ」〇ࡣྵࡲࢀ࡚࠸࡞࠸⤖ㄽࡉࢀ ࡿࠋ Ⓨ⾲ㄽᩥ Mohri, K., Nakamoto, A. and Shimizu, T. (2016) The ontogeny of nanos homologue expression in the oligochaete annelid Tubifex tubifex. Gene Expression Patterns 20: 32-41. Endo, M., Sakai, C. and Shimizu, T. (2016) Embryonic expression of Hox genes in the oligochaete annelid Tubifex tubifex. Developmental Dynamics, in press. ⏕≀⛉Ꮫ㒊㛛 ⏕ṪⓎ⏕⏕≀Ꮫศ㔝 㧗ᶫ Ꮥ⾜࣭Ⲷཎ ඞ┈ ⬨᳝ື≀ࡢ⏕Ṫჾᐁࡢᶵ⬟㛵ࡍࡿ◊✲ 㸦◊✲┠ⓗ㸧⬨᳝ື≀ࡢ⏕Ṫάືࡣ㸪どᗋୗ㒊㸦⬻㸧 㸫⬻ୗᆶయ㸫⏕Ṫ⭢ࡽ࡞ࡿ⏕ṪෆศἪ⣔ࡼࡾ ㄪ⠇ࡉࢀ㸪༸ᕢ࡛ࡘࡃࡽࢀࡿ༸⢭ᕢ࡛ࡘࡃࡽࢀ ࡿ⢭Ꮚࡢྜయ㸦ཷ⢭㸧ࡼࡾ᪂ࡋ࠸ಶయࡀ࡛ࡁࡿࠋ − 22 − ᙜ◊✲ᐊ࡛ࡣ㸪༸ᕢ㸪⢭ᕢ➼࠾ࡅࡿᵝࠎ࡞⌧㇟ ࢆศᏊ࡛ࣞ࣋ࣝゎᯒࡋࠊࡑࡢ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍ ࡿࡇࢆ┠ⓗ◊✲ࢆ㐍ࡵ࡚࠸ࡿࠋ㏆ᖺࡣࠊ⬨᳝ ື≀ࡢ༸࣓࢝ࢽࢬ࣒ࡢᐜゎ᫂ࢆ┠ᣦࡋ࡚◊✲ ࢆ⾜ࡗ࡚࠸ࡿࠋ 㸦⤒㐣࣭⤖ᯝ㸧 ᙜ◊✲ᐊ࡛ࡣ㸪ᐇ㦂ᮦᩱࡋ࡚࣓ࢲ࢝ࢆ⏝࠸࡚ ◊✲ࢆ⾜ࡗ࡚࠸ࡿࠋ࣓ࢲ࢝ࡣࠊ༸ᐇ⾜ᚲせ ྍḞ࡞㓝⣲㸦༸㓝⣲㸧ࡀࡍ࡛ྠᐃࡉࢀ࡚࠾ࡾࠊ ࡉࡽ⏕యእ࡛༸⌧㇟ࢆほᐹ࡛ࡁࡿᇵ㣴⣔ࡀ ⏝ྍ⬟࡞ࡇࡽࠊ༸◊✲㐺ࡋࡓᐇ㦂ື≀࡛ ࠶ࡿࠋ࣓ࢲ࢝ࢆ⏝࠸ࡓ༸◊✲ࡋ࡚௨ୗࡢ 3 ࢸ ࣮࣐ࡘ࠸࡚◊✲ࢆ⾜ࡗ࡚࠸ࡿࠋ 㸦1㸧ᡂ㛗࣍ࣝࣔࣥࡼࡿ༸ㄪ⠇ᶵᵓࡢゎ᫂ ᡂ㛗࣍ࣝࣔࣥࡣࠊ⣽⬊ศࢆಁࡍࡇࡼࡾᡂ 㛗ࠊ⏕ࢆಁ㐍ࡍࡿ࡛࣍ࣝࣔࣥ࠶ࡿࡀࠊ༸ᕢᶵ⬟ ࡶ㔜せ࡞ᙺࢆᣢࡘࡇࡀྂࡃࡽ▱ࡽࢀ࡚࠸ ࡿࠋᮏ◊✲࡛ࡣࠊ࣓ࢲ࢝༸ࡢᡂ㛗࣍ࣝࣔࣥࡢ 㛵ࡘ࠸࡚ㄪᰝࢆ⾜ࡗ࡚࠾ࡾࠊ༸ 36 㛫๓ ༢㞳ࡋࡓℐ⬊ࢆ࣓ࢲ࢝ࣜࢥࣥࣅࢼࣥࢺᡂ㛗࣍ࣝࣔ ࣥ(rGH)Ꮡᅾୗ࡛ᇵ㣴ࡍࡿࠊ༸㛵㐃㑇ఏᏊࡢㄏ ᑟ㛵ࡍࡿࡇࡀ᫂ࡽ࡞ࡗ࡚࠸ࡿ᰾ෆࣉࣟ ࢤࢫࢳࣥཷᐜయ(nPR)ࡢⓎ⌧ࢆ᭷ពቑຍࡉࡏࡿ ࡇࠊࡲࡓࠊℐ⬊ᇵ㣴⣔ࡢᐇ㦂⤖ᯝࡽ༸ 36 㛫๓ࡽ 24 㛫๓ࡢ㛫ᡂ㛗࣍ࣝࣔࣥࡀℐ⬊ స⏝ࡍࡿࡇࡀ♧၀ࡉࢀ࡚࠸ࡿࠋࡑࡇ࡛ࠊGH ࡼ ࡿ nPR ࡢⓎ⌧ㄏᑟ࣓࢝ࢽࢬ࣒ࡢヲ⣽ࢆ᫂ࡽࡍ ࡿࡓࡵࠊGH ࡼࡾㄏᑟ㸦ᢚไ㸧ࡉࢀࡿ㑇ఏᏊࡢ ⥙⨶ⓗ᥈⣴ࢆ⾜࠸ࠊnPR ㄏᑟ㛵ࡍࡿೃ⿵ᅉᏊ ࡢ᥈⣴ࢆ⾜ࡗࡓࠋලయⓗࡣࠊ༸ 36 㛫๓ࡢℐ ⬊ࢆࡃࡾᢤࡁࠊrGH ඹᇵ㣴ᚋࠊḟୡ௦ࢩ࣮ࢡ ࢚ࣥࢫゎᯒࢆ⾜ࡗࡓࠋࡑࡢ⤖ᯝࠊከᩘࡢ㑇ఏᏊࡀ rGH ࡼࡾㄏᑟࡶࡋࡃࡣᢚไࡉࢀࡿࡇࡀ᫂ࡽ ࡞ࡾࠊࡑࡢ㑇ఏᏊࡢ୰ࡽ㌿ᅉᏊ࠾ࡼࡧ㌿ ㄪ⠇ᅉᏊணࡉࢀࡿ㑇ఏᏊࡢ㑅ูࢆ⾜ࡗࡓࠋ ᚋࡣࠊࡇࢀࡽࡢᅉᏊࡢ nPR ㄏᑟࡢ㛵ࡢ᭷↓ ࡘ࠸࡚ゎᯒࢆ㐍ࡵࡿࠋ 㸦2㸧༸ᡂ⇍༸ࡢ㐃㛵ᛶ ༸ᡂ⇍ࡼࡾཷ⢭ྍ⬟࡞ࡗࡓ༸ẕ⣽⬊ࡀ༸ᕢ ⭍ᨺฟࠊ༸ࡉࢀࡿࠋࡘࡲࡾࠊ༸ẕ⣽⬊ࡀ༸ ᡂ⇍ᚋ༸ࡉࢀࡿࡇࡽࠊ୧⪅ࡢ㛫ࡣఱࡽ ࡢࢥ࣑ࣗࢽࢣʊࢩࣙࣥࡀᏑᅾࡍࡿࡇࡀணࡉ ࢀࡿࠋࡑࡇ࡛ࠊࡑࡢྍ⬟ᛶࡘ࠸᳨࡚ドࡋࡓࠋࡇ ࢀࡲ࡛ࡢゎᯒࡽࠊ༸ẕ⣽⬊ℐ⬊⣽⬊㛫࡛ࢥ࣑ ࣗࢽࢣʊࢩࣙࣥࢆࡿᡭẁࡋ࡚ࢠࣕࢵࣉࢪࣕࣥ ࢡࢩࣙࣥࢆࡋࡓศᏊࡢࡸࡾྲྀࡾࡀ㔜せ࡛࠶ࡿࡇ ࠊࡲࡓࠊ༸㔜せ࡞ᙺࢆᢸ࠺㓝⣲ࡢ 1 ࡘ࡛ ࠶ࡿ MT2-MMP ࡢⓎ⌧ㄏᑟࢠࣕࢵࣉࢪࣕࣥࢡࢩ ࣙࣥࡀ㛵ࡍࡿࡇࡀ♧၀ࡉࢀ࡚࠸ࡓࠋࡑࡇ࡛ࠊ ࢠࣕࢵࣉࢪࣕࣥࢡࢩࣙࣥࡀ MT2-MMP ࡢⓎ⌧ㄏᑟ ࡢࡼ࠺㛵ࡍࡿࡢࡘ࠸࡚ゎᯒࢆጞࡵࡓࠋ ⌧ᅾࡣࠊChIP assay ࡸ EMSA ࡞ࡼࡾࠊࢠࣕࢵ ࣉࢪࣕࣥࢡࢩࣙࣥ㜼ᐖ MT2-MMP ࡢ㌿㛤ጞ Ⅼୖὶ㡿ᇦ nPR ࡀ⤖ྜࡍࡿ࠺ࡘ࠸࡚ゎ ᯒ୰࡛࠶ࡿࠋ ࢠࣕࢵࣉࢪࣕࣥࢡࢩࣙࣥࡢせᵓᡂᅉᏊࡣࠊࢥ ࢿ࢟ࢩࣥࢱࣥࣃࢡ㉁࡛࠶ࡿࠋࡑࡇ࡛ࠊࡇࡢࢱࣥࣃ ࢡ㉁ࡢⓎ⌧ኚືࡸᒁᅾࡘ࠸࡚ㄪᰝࡋࡓࠋ༸๓ ℐ⬊࠾࠸࡚ࠊఱ✀㢮ࡢࢥࢿ࢟ࢩࣥ mRNA ࡢⓎ ⌧ࡀ☜ㄆࡉࢀࡓࡢ࡛ࠊࡑࢀࡽࡘ࠸࡚ᢠయࢆస〇 ࡋࠊゎᯒࢆ⾜ࡗࡓࠋస〇ࡋࡓᢠయࡢ࠺ࡕࠊᢠཎࢆ ㄆ㆑ࡍࡿᢠయࡣ 1 ✀ࡢࡳ࡛࠶ࡗࡓࡇࡽࠊࡇࢀ ࡘ࠸࡚ࡢࡳゎᯒࢆ⾜ࡗࡓࠋࡇࡢᢠయࡀ native ࡢ ࢥࢿ࢟ࢩࣥࢆ≉␗ⓗㄆ㆑ࡋࡓࡇࡽࠊ༸๓ ℐ⬊࠾ࡅࡿᒁᅾࢆㄪᰝࡋࡓ⤖ᯝࠊ㢛⢏⭷⣽⬊ᒙ Ⓨ⌧ࡍࡿࡇࡀほᐹࡉࢀࡓࠋᚋࡣࠊ㟁㢧ࢆ⏝ ࠸࡚ࠊࡼࡾヲ⣽࡞Ⓨ⌧㒊ࢆㄪᰝࡍࡿணᐃ࡛࠶ࡿࠋ 㸦3㸧࣓ࣛࢺࢽࣥࡼࡿ༸ㄏᑟᶵᵓࡢゎ᫂ ࣓ࣛࢺࢽࣥࡣࠊ╧╀ㄏᑟస⏝ࢆࡶࡘ࣍ࣝࣔࣥ ࡋ࡚᭷ྡࡔࡀࠊࡑࢀ௨እࡶᵝࠎ࡞⏕⌮⌧㇟㛵 ࡍࡿࠋᙜ◊✲ᐊࡢゎᯒࡽࠊࡇࡢ࣍ࣝࣔࣥࡀ࣓ ࢲ࢝༸ࡶ㛵ࡍࡿࡇࡀุ᫂ࡋ࡚࠾ࡾࠊ༸ ㄏᑟస⏝ࢆࡶࡘࣉࣟࢫࢱࢢࣛࣥࢪࣥ E2 ࡢ⏘⏕㓝 ⣲ࡢ 1 ࡘ࡛࠶ࡿ cPLA2 ࡢⓎ⌧ไᚚ࣓ࣛࢺࢽࣥࡀ 㛵ࡍࡿࡇ࡛ࠊ࣓ࢲ࢝༸㛫᥋ⓗ㛵ࡋ࡚ ࠸ࡿࡇࡀ᫂ࡽ࡞ࡗ࡚࠸ࡿࠋࡲࡓࠊ࣓ࣛࢺࢽ ࣥࡀ༸ࡢࢡࢳࣥࣇ࣓ࣛࣥࢺࡢᵓ⠏㛵 ࡍࡿࡇࡶ᫂ࡽ࡞ࡗ࡚࠸ࡿࡀࠊᅇࡢゎᯒ ࡽࠊ࣓ࣛࢺࢽࣥࡀ Moesin A ࡢࣜࣥ㓟ࢆㄏᑟࡍ ࡿࡇࡼࡾࢡࢳࣥࣇ࣓ࣛࣥࢺࡢᵓ⠏㛵 ࡍࡿࡇࡀ᫂ࡽ࡞ࡗࡓࠋ࣓ࣛࢺࢽࣥࡢస⏝ ࡼ ࡾ Moesin A ࡢ ࣜ ࣥ 㓟 ࡀ ㄏ ᑟ ࡉ ࢀ ࡿ Moesin A ࢆࡋ࡚⣽⬊⭷ୖཷᐜయࢡࢳࣥࣇ ࣓ࣛࣥࢺࡀ⤖ྜࡍࡿࠋࡇࡢ⤖ྜࡀ่⃭࡞ࡾࠊ ࢡࢳࣥࣇ࣓ࣛࣥࢺࡢ⬺㔜ྜࡀಁ㐍ࡉࢀࠊ༸ࡀ ㄏᑟࡉࢀࡿணࡉࢀࡿࠋ ㄽᩥ Ogiwara, K., and Takahashi, T. 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ᏛⓎ⾲ Ⲷཎඞ┈ࠊ㧗ᶫᏕ⾜㸸 ࣓ࢲ࢝༸࠾࠸࡚࣓ࣛࢺࢽࣥࡣ PGE2 ⏘⏕ ࢡࢳࣥ⧄⥔ࡢᵓ⠏㛵ࡍࡿ ᪥ᮏື≀Ꮫ➨ 86 ᅇࠊᖹᡂ 27 ᖺ 9 ᭶ 17 ᪥ࠊ ᪂₲ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮㸦᪂₲ᕷ㸧 Ὢ㙊࡞ࡘࠊⲶཎඞ┈ࠊ㧗ᶫᏕ⾜㸸 ࣓ࢲ࢝༸ℐ⬊࠾ࡅࡿ༸ᡂ⇍༸ࡢ㛵ಀ ᪥ᮏື≀Ꮫ➨ 86 ᅇࠊᖹᡂ 27 ᖺ 9 ᭶ 17 ᪥ࠊ ᪂₲ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮㸦᪂₲ᕷ㸧 Ὢ㙊࡞ࡘࠊⲶཎඞ┈ࠊ㧗ᶫᏕ⾜㸸 ༸༸ᡂ⇍ࡣ communication ࢆࡗ࡚࠸ࡿ㸽 㹼༸࠾ࡅࡿ Gap junction ࡢ㛵㹼 ᪥ᮏศᏊ⏕≀Ꮫ➨ 38 ᅇᖺࠊᖹᡂ 27 ᖺ 12 ᭶ 2 ᪥ࠊ⚄ᡞ࣏࣮ࢺࣛࣥࢻ㸦⚄ᡞᕷ㸧 ⏕≀⛉Ꮫ㒊㛛 ⏕ṪⓎ⏕⏕≀Ꮫศ㔝 ᮌᮧ ᩔ 㸺◊✲ㄢ㢟ྡ㸼 ့ங㢮ࡢ⏕Ṫ㛵ࢃࡿࢤࣀ࣒ᶵ⬟㛵ࡍࡿ◊✲ 㸺⏝≧ἣ࣭ᡂᯝ㸼 ᙜ◊✲ᐊ࡛ࡣࠊ့ங㢮ࡢ⏕Ṫ࠾ࡅࡿࢤࣀ࣒ ᶵ⬟ࢆゎ᫂ࡍࡿࡇࢆ┠ⓗࡋ࡚ࠊ⏕Ṫჾᐁ࠾ ࡅࡿ㑇ఏᏊⓎ⌧ㄪ⠇ᶵᵓࢆㄪᰝࡋ࡚࠸ࡿࠋලయⓗ ࡣ༸ᕢࠊ⢭ᕢࠊ⫾┙࡛Ⓨ⌧ࡍࡿࡉࡲࡊࡲ࡞㑇ఏ Ꮚࡀࡢࡼ࠺࡞࣓࢝ࢽࢬ࣒࡛ไᚚࡉࢀ࡚࠸ࡿࡢ ࢆศᏊ࡛ࣞ࣋ࣝㄪ࡚࠾ࡾࠊᚲせᛂࡌ࡚㑇ఏᏊ ࡢᶵ⬟ゎᯒࡶ⾜ࡗ࡚࠸ࡿࠋᖺᗘࡣ⢭ᕢ≉␗ⓗ࡞ ࣐࢘ࢫ Tessp-2 㑇ఏᏊࡢ㌿ㄪ⠇࣓࢝ࢽࢬ࣒ࡘ ࠸࡚᪂ࡋ࠸▱ぢࢆᚓࡓࠋ ⢭Ꮚᙧᡂ࡛ࡣῶᩘศ㐣⛬ࡢ⢭ẕ⣽⬊࡛ከࡃ ࡢ㑇ఏᏊࡀάᛶࡉࢀ࡚ᶵ⬟ࡍࡿࡇࡀ▱ࡽࢀ࡚ ࠸ࡿࡀࠊࡑࡢάᛶ࣓࢝ࢽࢬ࣒ࡣ᫂ࡽ࡛ࡣ࡞࠸ࠋ ᙜ◊✲ᐊ࡛ࡣ࣐࢘ࢫ Tessp 㑇ఏᏊࢡࣛࢫࢱ࣮ࢆࣔ ࢹࣝࡢ 1 ࡘࡋ࡚ࡇࡢ࣓࢝ࢽࢬ࣒ゎ᫂ᣮࢇ࡛࠸ ࡿࠋ࣐࢘ࢫ Tessp 㑇ఏᏊࢡࣛࢫࢱ࣮ࡣ 9 ␒ᰁⰍయ ୖᏑᅾࡋ࡚࠾ࡾࠊࢭࣜࣥࣉࣟࢸ࣮ࢮࢆࢥ࣮ࢻ ࡍࡿ 3 ࡘࡢࣃࣛࣟࢢ㑇ఏᏊࡽᡂࡿࠋ3 ࡘࡢ㑇ఏ Ꮚࡣ࠸ࡎࢀࡶ⢭ᕢ࠾࠸࡚ࣃ࢟ࢸࣥᮇࡢ୍ḟ⢭ẕ ⣽⬊࡛≉␗ⓗάᛶࡋ࡚ࠊῶᩘศࡢ㐍⾜㔜 せ࡞ᙺࢆᯝࡓࡍ⪃࠼ࡽࢀ࡚࠸ࡿࠋᅇࡣࡇࡢ Tessp 㑇ఏᏊࢡࣛࢫࢱ࣮ࡢάᛶ࣓࢝ࢽࢬ࣒ࢆ▱ ࡿࡓࡵࠊDNase I 㧗ឤཷᛶ㡿ᇦ㸦DNase I HS㸧ࡢ ᥈⣴ long noncoding RNA㸦lncRNA㸧ࡢゎᯒࢆ⾜ ࡗࡓࠋࡑࡢ⤖ᯝࠊࢡࣛࢫࢱ࣮୰ࡢ Tessp-2 㑇ఏᏊ ㏆ྜィ 8 ࡘࡢ DNase I HS ࢆⓎぢࡋࠊࡑࡢ࠺ࡕ Tessp-2 㑇ఏᏊࣉ࣮ࣟࣔࢱ࣮Ꮡᅾࡍࡿ 3 ࡘࡀ⢭ᕢ ⏕Ṫ⣽⬊≉␗ⓗ࡛࠶ࡗࡓࠋࡲࡓࠊTessp-2 㑇ఏᏊୗ ὶࡢ DNase I HS ㏆ഐࡽ⢭ᕢ≉␗ⓗ࡞᪂つࡢ lncRNA ࢆ Ⓨ ぢ ࡋ ࡚ ࢡ ࣟ ࣮ ࢽ ࣥ ࢢ ᡂ ຌ ࡋ ࠊ lncRNA-HSVIII ྡ࡙ࡅࡓࠋ lncRNA-HSVIII ࡣ⢭ᕢ࠾࠸࡚⏕Ṫ⣽⬊ࡢ᰾ Ꮡᅾࡍࡿ࠺࠼ࠊlncRNA-HSVIII ࡀ㌿ࡉࢀࡿࢤࣀ࣒ 㡿ᇦࡀ࣐࢘ࢫࡢ⢭ẕ⣽⬊࠾࠸࡚ Tessp-2 㑇ఏᏊ ࣉ࣮ࣟࣔࢱ࣮┦స⏝ࡍࡿࡇࡽࠊTessp-2 㑇 ఏᏊࡢㄪ⠇㛵ࢃࡿྍ⬟ᛶࢆ᳨ドࡋࡓࠋࡋࡋࠊ ᇵ㣴⣽⬊ࢆ⏝࠸ࡓ㐣Ⓨ⌧ᐇ㦂ࡸ࣏࣮ࣞࢱ࣮㑇ఏ Ꮚࢆ⏝࠸ࡓゎᯒࡼࡗ࡚ࠊlncRNA-HSVIII ࡀ Tessp-2 㑇ఏᏊࡢㄪ⠇㛵ࢃࡿドᣐࡣᚓࡽࢀ࡞ࡗࡓࠋࡑ ࡢ௦ࢃࡾࠊlncRNA-HSVIII ࡀ㌿ࡉࢀࡿ㓄ิ㞄᥋ ࡍࡿࢤࣀ࣒㡿ᇦࡀ Tessp-2 㑇ఏᏊࣉ࣮ࣟࣔࢱ࣮ ᑐࡋ࡚࢚ࣥࣁࣥࢧ࣮άᛶࢆ♧ࡍࡇࡀࢃࡗࡓࠋ ࡘࡲࡾࠊ࣐࢘ࢫࡢ⢭ẕ⣽⬊࠾࠸࡚ lncRNA-HSVIII ࿘㎶㓄ิࡀ Tessp-2 㑇ఏᏊάᛶࡢ࢚ࣥࣁࣥࢧ࣮ ࡋ࡚ᶵ⬟ࡍࡿࡇࡀ♧၀ࡉࢀࡓࠋ୍᪉࡛ࠊ lncRNA-HSVIII ࡣῶᩘศ㐣⛬࡛ࡑࡢᒁᅾࢆ᰾ ࡽ⣽⬊㉁ኚࡉࡏࡿࡇࡶ᫂ࡽ࡞ࡾࠊ Tessp-2 㑇ఏᏊࡣ㛵ಀࡢ࡞࠸」ᩘࡢᶵ⬟ࢆᣢࡘ ࡇࡀ⪃࠼ࡽࢀࡿࠋ 㸺ᣍᚅㅮ₇㸼 1. ᮌᮧᩔࠕ࣐࢘ࢫ⢭Ꮚᙧᡂ࠾࠸࡚≉␗ⓗ㌿ ࡉࢀࡿ㛗㙐㠀ࢥ࣮ࢻRNAࡼࡿ㑇ఏᏊάᛶ 㸭Gene activation by long noncoding RNAs specifically transcribed during mouse spermatogenesisࠖBMB2015࣮࣡ࢡࢩࣙࢵࣉ㸸 㛗㙐㠀ࢥ࣮ࢻRNAࡢࣇࣟࣥࢸ㸸⏕Ꮫࠊ ศᏊ⏕≀Ꮫࠊ་Ꮫࡽࡢࣉ࣮ࣟࢳ㸦⚄ᡞ࣏ ࣮ࢺࣛࣥࢻࠊ2015ᖺ12᭶2᪥㸧 㸺ᏛⓎ⾲㸼 1. ᒣඃᶞࠊᯇཎఙࠊᮌᮧᩔࠕ࣐࢘ࢫࣉࣟࣜࣝ࢜ ࣜࢦ࣌ࣉࢳࢲ࣮ࢮࡢ≉␗ⓗ࡞㜼ᐖࡣ⫾┙ᖿ⣽ ⬊ ࡢ ศ ࢆ ᢚ ไ ࡍ ࡿ 㸭 Specific inhibition of mouse prolyl oligopeptidase suppresses placental trophoblast stem cell differentiationࠖBMB2015㸦⚄ ᡞ࣏࣮ࢺࣛࣥࢻࠊ2015 ᖺ 12 ᭶ 3 ᪥㸧 2. బ⸨ඃ⾰ࠊ⡿⏣❳㤿ࠊྜྷ⏣㑳ஓࠊᮌᮧᩔࠕ࣐࢘ ࢫ⢭ẕ⣽⬊࠾ࡅࡿ Tessp-2 㑇ఏᏊࡢ㌿άᛶ ᶵᵓ㸭Transcriptional activation of the Tessp-2 gene in mouse spermatocytesࠖBMB2015㸦⚄ᡞ࣏ ࣮ࢺࣛࣥࢻࠊ2015 ᖺ 12 ᭶ 1 ᪥㸧 − 24 − 3. బ⸨ඃ⾰ࠊྜྷ⏣㑳ஓࠊᮌᮧᩔࠕ࣐࢘ࢫ⢭ẕ⣽⬊ ≉␗ⓗ Tessp-2 㑇ఏᏊάᛶᐤࡍࡿ long noncoding RNA ࡢゎᯒࠖ᪥ᮏື≀Ꮫ➨ 86 ᅇ ᪂₲㸦᪂₲ᕷᮒ㮛࣓ࢵࢭࠊ2015 ᖺ 9 ᭶ 19 ᪥㸧 4. ᒣඃᶞࠊᯇཎఙࠊᮌᮧᩔࠕ࣐࢘ࢫࣉࣟࣜࣝ࢜ ࣜࢦ࣌ࣉ ࢳࢲ࣮ࢮࢆᶆⓗࡋࡓ⫾┙ࡢ᪂つศ 㜼ᐖ⣔ࡢ☜❧ゎᯒࠖ᪥ᮏື≀Ꮫ➨ 86 ᅇ ᪂₲㸦᪂₲ᕷᮒ㮛࣓ࢵࢭࠊ2015 ᖺ 9 ᭶ 19 ᪥㸧 5. బ⸨ඃ⾰ࠊ⡿⏣❳㤿ࠊᮌᮧᩔࠕ࣐࢘ࢫ⢭ᕢ≉␗ ⓗ long noncoding RNA ࡼࡿ Tessp 㑇ఏᏊάᛶ ࡢ ᳨ ド 㸭 Verification of mouse Tessp gene activation by testis-specific long noncoding RNAsࠖ➨ 17 ᅇ᪥ᮏ RNA Ꮫᖺ㸦ᮐᖠࠊ2015 ᖺ 7 ᭶ 16 ᪥㸧 ⏕≀⛉Ꮫ㒊㛛 ⏕ṪⓎ⏕⏕≀Ꮫศ㔝 ᑠ㇂ ஓ 㸺Pumilio1 ࡼࡿ mRNA ⩻ヂไᚚᶵᵓࡢゎᯒ㸦㰺 ⸨ ⠜㸧㸼 ༸ẕ⣽⬊ࡣࡑࡢᙧᡂ㐣⛬࠾࠸࡚ࠊ⩻ヂࢆᢚไ ࡋࡓᵝࠎ࡞✀㢮ࡢ mRNA ࢆ⣽⬊㉁✚ࡍࡿࠋ ࡇࢀࡽ mRNA ࡀ㐺ษ࡞ሙᡤ㐺ษ࡞ࢱ࣑ࣥࢢ ࡛⩻ヂࡉࢀࡿࡇࡣࠊ༸ẕ⣽⬊ࡢᡂ⇍ࡑࡢᚋࡢ ึᮇⓎ⏕ࡢ㐍⾜㔜せ࡛࠶ࡿࠋ༸ẕ⣽⬊✚ࡉ ࢀࡓ mRNA ࡢ⩻ヂࡣࠊ⺮ⓑ㉁ࡢ┤᥋ⓗ࠶ࡿ࠸ࡣ 㛫᥋ⓗ࡞⤖ྜࡼࡾไᚚࡉࢀࡿࠋPumilio1 ࡣ㓝ẕ ࡽࣄࢺࡲ࡛ከࡃࡢ✀ಖᏑࡉࢀࠊC ᮎ➃㒊 RNA ⤖ྜ㡿ᇦࢆᣢࡘࠋPumilio1 ⺮ⓑ㉁ࡣࡇࡢ RNA ⤖ྜ㡿ᇦࢆࡋ RNA ┤᥋⤖ྜࡍࡿࡇ࡛ࠊᶆⓗ mRNA ࡢᏳᐃ⩻ヂไᚚ㛵ࢃࡿࠋᡃࠎࡣࠊ༸ ẕ⣽⬊࠾࠸࡚ Pumilio1 ࡀᶆⓗ mRNA ࡢ⩻ヂά ᛶඛ❧ࡗ࡚ࣜࣥ㓟ࢆཷࡅࡿࡇࢆ♧ࡋࡓࠋ ࡋࡋ Pumilio1 ࡼࡿ mRNA ࡢ⩻ヂไᚚᶵᵓࡣᮍ ゎ᫂࡞㒊ศࡀከ࠸ࠋ ᮏ◊✲࡛ࡣ GFP ⼥ྜ Pumilio1 (GFP-Pum1)ࢆ༸ ẕ⣽⬊࡛Ⓨ⌧ࡉࡏࠊPumilio1 ࡼࡿ mRNA ⩻ヂไ ᚚᶵᵓࡢゎ᫂ࢆ┠ᣦࡋࡓࠋ༸ẕ⣽⬊࡛Ⓨ⌧ࡉࡏࡓ GFP-Pum1 ࡣࠊ⣽⬊㉁࠾࠸࡚ከᩘࡢจ㞟యࢆᙧ ᡂࡋࡓࠋ୍᪉ࠊN ᮎ➃ഃᏑᅾࡍࡿ QN-rich region ࢆḞኻࡉࡏࡓ GFP-Pum1 ǻQN ࡣจ㞟యࢆᙧᡂࡋ࡞ ࡗࡓࠋᚑࡗ࡚ࠊPumilio1 ࡣ QN-rich region ࢆࡋ ࡚จ㞟ࡍࡿ⪃࠼ࡽࢀࡿࠋࣜࣝࢱ࣒࡛ GFP ⺯ගࢆほᐹࡋࡓ⤖ᯝࠊGFP-Pum1 ࡢจ㞟యࡣ༸ᡂ ⇍ࡢ㐍⾜కࡗ࡚ᣑᩓࡍࡿࡇࡀ᫂ࡽ࡞ࡗࡓࠋ จ㞟యࡢᣑᩓࡢࢱ࣑ࣥࢢࡣᶆⓗ mRNA ࡢ⩻ヂά ᛶඛ❧ࡕࠊPumilio1 ࡢࣜࣥ㓟⥆࠸࡚㉳ࡇ ࡗࡓࠋ௨ୖࡢ⤖ᯝࡼࡾࠊPumilio1 ࡣจ㞟యࡢᙧᡂ ࣜࣥ㓟ࡼࡿจ㞟యࡢᣑᩓࡼࡗ࡚ࠊ༸ᡂ⇍ ࠾ࡅࡿᶆⓗ mRNA ࡢ⩻ヂࢆไᚚࡍࡿྍ⬟ᛶࡀ♧ ࡉࢀࡓࠋPumilio1 ࡢࣜࣥ㓟ཬࡧจ㞟యࡢᣑᩓࠊ ᶆⓗ mRNA ࡢ⩻ヂάᛶࡢ┤᥋ⓗ࡞㛵ಀᛶࢆ♧ ࡍࡇࡀᚋࡢㄢ㢟࡛࠶ࡿࠋ 㸺࣐࢘ࢫ༸ẕ⣽⬊࠾ࡅࡿ Balbiani body mRNA ࡢᒁᅾࡢ㛵ಀ㸦୰ᮧ ᣅ☻㸧㸼 ༸ẕ⣽⬊ࡀᣢࡘື≀ᴟ࣭᳜≀ᴟࡣࠊ⬇ࡢ⫼⭡㍈ ࡢᙧᡂ㔜せ࡛࠶ࡿࠋ㨶㢮ࡸ୧⏕㢮࡞ࡢୗ➼⬨ ᳝ື≀࡛ࡣࠊື࣭᳜≀ᴟࡣ༸ᙧᡂࡢึᮇࡢẁ㝵࡛ ᙧᡂࡉࢀࡿࠋࡇࢀࡽࡢ༸ẕ⣽⬊࡛ࡣࠊ༸ཎ⣽⬊ ࡽ༸ẕ⣽⬊ศࡋࡓᚋ Balbiani body (BB) ࡤࢀࡿ㠀ᑐ⛠࡞⣽⬊ෆᵓ㐀ࡀᙧᡂࡉࢀࡿࠋ့ங㢮 ࠾࠸࡚ࡶࠊBB ࡣ᪂⏕༸ᕢ࠾ࡅࡿึᮇࡢ༸ẕ ⣽⬊ぢࡽࢀࡿࠋୗ➼⬨᳝ື≀࡛ࡣࠊBB ࡢᙧᡂ ࡼࡗ࡚ື࣭᳜≀ᴟࡀỴᐃࡉࢀࡿࡀࠊ့ங㢮༸ẕ⣽ ⬊ࡀື࣭᳜≀ᴟࢆᣢࡘࡣ᫂☜࡛ࡣ࡞࠸ࠋᡃࠎࡣࠊ ࣐࢘ࢫ༸ẕ⣽⬊࠾࠸࡚ Cyclin B1 mRNA ࡀ㨶㢮 ྠᵝ㠀ᑐ⛠ศᕸࡍࡿࡇࢆぢ࠸ࡔࡋࡓࠋᮏ ◊✲ࡣࠊ࣐࢘ࢫ༸ẕ⣽⬊࠾ࡅࡿື࣭᳜≀ᴟࡢᙧ ᡂࢆ᥈ࡿࡓࡵࠊBB mRNA ࡢᒁᅾࡢ㛵ಀࢆ᫂ࡽ ࡍࡿࡇࢆ┠ⓗࡋࡓࠋ ᡂయ᪂⏕ࡢ༸ᕢࡘ࠸࡚ࠊCyclin B1 ࡢࣉࣟ ࣮ࣈࢦࣝࢪయࢱࣥࣃࢡ㉁ࡢ GM130 ࢆㄆ㆑ࡍࡿ ᢠయࢆ⏝࠸࡚ in situ hybridization චᰁⰍࢆྠ ⾜ࡗࡓࠋฟ⏕ᚋ 4 ᪥┠ࡢ࣐࢘ࢫ࠾࠸࡚ BB ࡣ࡚ࡢ༸ẕ⣽⬊࡛ぢࡽࢀࠊඛሗ࿌ࡉࢀࡓ㍯ᆺ ࡢᵓ㐀ࢆ☜ㄆ࡛ࡁࡓࠋࡇࡢᮇ Cyclin B1 mRNA ࡣᒁᅾࡏࡎ༸ẕ⣽⬊ࡢయ㢛⢏≧࡛Ꮡᅾࡋࡓࠋ ฟ⏕ᚋ 8 ᪥┠࡛ BB ࡣ᳨ฟ࡛ࡁࡎࠊࡇࡢᮇࡢ༸ ẕ⣽⬊࡛ࡣ BB ࡀᾘኻࡋ࡚࠸ࡿࡇࡀ♧၀ࡉࢀࡓࠋ ࡲࡓࠊCyclin B1 mRNA ࡣᒁᅾࡏࡎ༸ẕ⣽⬊ࡢ య㢛⢏≧࡛Ꮡᅾࡋࡓࠋᡂయ࣐࢘ࢫࡢ༸ẕ⣽⬊࡛ ࡣ BB ࡣ᳨ฟࡉࢀࡎࠊCyclin B1 mRNA ࡣ㠀ᑐ⛠ ᒁᅾࡍࡿࡇࡀ☜ㄆ࡛ࡁࡓࠋᮏ◊✲ࡼࡾࠊ᪂⏕ ࣐࢘ࢫࡢ༸ẕ⣽⬊࠾࠸࡚ࠊBB Cyclin B1 mRNA ࡢศᕸࡣ㨶㢮ྠᵝ࡛࠶ࡿࡀࠊBB ᾘኻᚋ Cyclin B1 mRNA ࡀᒁᅾࡍࡿ㐣⛬ࡀ㨶㢮␗࡞ࡿ ࡇࡀ᫂ࡽ࡞ࡗࡓࠋ Ⓨ⾲ㄽᩥ Nukada, Y., Horie, M., Fukui, A., Kotani, T., Yamashita, M. (2015) Real-time imaging of actin filaments in the zebrafish oocyte and embryo. Cytoskeleton, 72: 491-501. ᏛⓎ⾲ ᕝᮧ⩧ᖹ, 㰻⸨⠜, John Carroll, ᑠ㇂ஓ㸸༸ẕ⣽ ⬊࠾ࡅࡿ Pumilio1 ᶆⓗ mRNA ࡢᒁᅾ⩻ヂᶵᵓ. − 25 − ➨ 17 ᅇ᪥ᮏ RNA Ꮫᖺ, 2015 ᖺ 7 ᭶ 16 ᪥, ࣍ ࢸࣝࣛࣇ࢛࣮ࢺᮐᖠ㸦ᮐᖠᕷ㸧. ᇼỤ┿, ᑠ㇂ஓ㸸ࢮࣈࣛࣇࢵࢩࣗ༸ᡂ⇍㐣 ⛬࠾ࡅࡿ㢛⢏ᙧᡂࢆࡋࡓ mos mRNA ⩻ヂไᚚ ᶵᵓ. ᪥ᮏື≀Ꮫ➨ 86 ᅇ᪂₲, 2015 ᖺ 9 ᭶ 17 ᪥, ᮒ㮛࣓ࢵࢭ㸸᪂₲ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮ 㸦᪂₲ᕷ㸧 㰻⸨⠜, ᑠ㇂ஓ㸸࣐࢘ࢫ༸ᡂ⇍࠾ࡅࡿ⩻ヂไ ᚚᅉᏊ Pumilio1 ࡢᒁᅾࣜࣥ㓟. ᪥ᮏື≀Ꮫ ➨ 86 ᅇ᪂₲, 2015 ᖺ 9 ᭶ 19 ᪥, ᮒ㮛࣓ࢵࢭ㸸 ᪂₲ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮㸦᪂₲ᕷ㸧 ᕝᮧ⩧ᖹ, ᑠ㇂ஓ㸸࣐࢘ࢫ༸ẕ⣽⬊ࡢᰁⰍయศ 㓄㔜せ࡞ Mad2 mRNA ࡢ⩻ヂไᚚᶵᵓゎᯒ. ᪥ ᮏື≀Ꮫ➨ 86 ᅇ᪂₲, 2015 ᖺ 9 ᭶ 19 ᪥, ᮒ 㮛࣓ࢵࢭ㸸᪂₲ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮㸦᪂₲ᕷ㸧 㰻⸨⠜, ᑠ㇂ஓ㸸ࢮࣈࣛࣇࢵࢩࣗ༸ẕ⣽⬊ ࠾࠸࡚ Pumilio1 ࡢࣜࣥ㓟ࡣ cyclin B1 mRNA ࡢ⩻ ヂඛ❧ࡗ࡚㉳ࡇࡿ. ➨ 38 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ , 2015 ᖺ 12 ᭶ 2 ᪥, ⚄ᡞ࣏࣮ࢺࣛࣥࢻ㸦⚄ ᡞᕷ㸧 species (Nemertea: Hoplonemertea). Zoological Studies 54: 10. doi 10.1186/s40555-014-0086-3 [Springer Open Journal] Chernyshev, A. V., Abukawa, S., and Kajihara, H. 2015. Sonnenemertes cantelli gen. et sp. nov. (Heteronemertea)—a new Oxypolella-like nemertean from the abyssal plain adjacent to the Kuril–Kamchatka Trench. Deep-Sea Research II 111: 119–127. [ScienceDirect] Hao, Y., Kajihara, H., Chernyshev, A. V., Okazaki, R. K., and Sun, S. -C. 2015. DNA taxonomy of Paranemertes (Nemertea: Hoplonemertea) with spirally fluted stylets. Zoological Science 32: 571–578. Hiruta, S. F. and Hiruta, S. 2015. Description of a species of Fabaeformiscandona (Ostracoda, Crustacea) from Kushiro Marsh, Hokkaido, Japan, with the nearly complete mitochondrial genomic sequence. Biodiversity Data Journal 3: e7074, Ito, M., Onishi, T., and Dick, M. H. 2015. Cribrilina mutabilis n. sp., an eelgrass-associated bryozoan (Gymnolaemata: Cheilostomata) with large variation in zooid morphology related to life history. Zoological Science 32: 485–497. ୰ᮧᣅ☻, ᑠ㇂ஓ㸸㑇ఏᏊࢺࣛࢵࣉἲࡼࡿ᪂ つẕᛶᅉᏊࡢྠᐃᶵ⬟ゎᯒ. ➨ 38 ᅇ᪥ᮏศᏊ⏕ ≀Ꮫᖺ, 2015 ᖺ 12 ᭶ 3 ᪥, ⚄ᡞ࣏࣮ࢺࣛ ࣥࢻ㸦⚄ᡞᕷ㸧 Kajihara, H. 2015. A histology-free description of the branched-proboscis ribbonworm Gorgonorhynchus albocinctus sp. nov. (Nemertea: Heteronemertea). Publications of the Seto Marine Biological Laboratory 43: 92–102. ⏕≀⛉Ꮫ㒊㛛 ከᵝᛶ⏕≀Ꮫศ㔝 ᯳ཎ ᏹ 㸦ᾏỈ⏝㸧 Kajihara, H., Ikoma, M., Yamasaki, H., and Hiruta, S. F. 2015. Trilobodrilus itoi sp. nov., with a re-description of T. nipponicus (Annelida: Dinophilidae) and a molecular phylogeny of the genus. Zoological Science 32: 405–417. ㄽᩥ Kajihara, H., Hosokawa, I., Hosokawa, J., and Yoshida, R. 2016. Records of Notospermus tricuspidatus (Quoy & Gaimard, 1833) (Nemertea: Pilidiophora) in Japanese waters, with a review of warm-water green-bodied heteronemerteans from the Indo–West-Pacific. Fauna Ryukyuana 28: 59–65. Kakui, K. 2016. Descriptions of two new species of Rhizorhina Hansen, 1892 (Copepoda: Siphonostomatoida: Nicothoidae) parasitic on tanaidacean crustaceans, with a note on their phylogenetic position. Systematic Parasitology 93: 57–68. Alfaya, J. E. F., Bigatti, G., Kajihara, H., Strand, M., Sundberg, P., and Machordom, A. 2015. DNA barcoding supports identification of Malacobdella Kajihara, H., Kakui, K., Yamasaki, H., and Hiruta, S. F. 2015. Tubulanus tamias sp. nov. (Nemertea: Palaeonemertea) with two different types of epidermal eyes. Zoological Science 32: 596–604. Kajihara, H., Nishi, E., Kawabata, M., Kohtsuka, H. and Uyeno, D. 2015. Records of the poorly known ribbon worm Nipponnemertes ogumai (Nemertea: Monostilifera) and its phylogenetic position. Marine Biodiversity 45: 175–182. [Springer] Kajihara, H., Tomioka, S., Kakui, K., and Iseto, T. 2015. Phylogenetic position of the queer, backward-bent entoproct Loxosoma axisadversum (Entoprocta: Solitaria: Loxosomatidae). Species Diversity 20(1): 83–88.[JSSZ] Kakui, K. 2015. First report of Zeuxo sp. (Crustacea: − 26 − Tanaidacea) as prey for the forktongue goby, Chaenogobius annularis Gill, 1859. Rishiri Studies 34: 1–6. [in Japanese with English abstract and caption] Kakui, K. and Kohtsuka, H. 2015. Two new shallow-water species of Agathotanais (Crustacea: Tanaidacea) from Japan. Species Diversity 20(1): 45–58. [JSSZ] Kakui, K. and Naruse, T. 2015. Indoapseudes bamberi sp. nov. (Crustacea: Tanaidacea: Pagurapseudidae: Hodometricinae) from Iriomote Island, Ryukyu Islands, southwestern Japan. Zootaxa 3995: 138–148. Nakano, H., Kakui, K., Kajihara, H., Shimomura, M., Jimi, N., Tomioka, S., Tanaka, H., Yamasaki, H., Tanaka, M., Izumi, T., Okanishi, M., Yamada, Y., Shinagawa, H., Sato, T., Tsuchiya, Y., Omori, A., Sekifuji, M., and Kohtsuka, H. 2015. JAMBIO Coastal Organism Joint Surveys reveals undiscovered biodiversity around Sagami Bay. Regional Studies in Marine Science 2(supplement): 77–81. Nishi, E., Matsuo, K., Capa, M., Tomioka, S., Kajihara, H., Kupriyanova, E. K., and Polgar, G. 2015. Sabellaria jeramae, a new species (Annelida: Polychaeta: Sabellariidae) from the shallow waters of Malaysia, with a note on the ecological traits of reefs. Zootaxa 4052: 555–568. Shimada, D. and Kakui, K. 2015. First record of the free-living marine nematode Deontostoma magnificum (Timm, 1951) Platonova, 1962 (Nematoda: Leptosomatidae) from Japan. Nematological Research 45: 13–18. Sun, S. -C., Kajihara, H., and Chernyshev, A. V. 2015. Special issue: proceedings of the 8th international conference on nemertean biology. Zoological Science 32: 499–500. Uyeno, D. and Kakui, K. 2015. The first record of a species of Clausiidae (Copepoda: Cyclopoida) from Japanese waters, with the proposal of a new genus. Species Diversity 20: 153–158. Woo, S. P., Yasin, Z., Tan, S. H., Kajihara, H., and Fujita, T. 2015. Sea cucumbers of the genus Stichopus Brandt, 1835 (Holothuroidea, Stichopodidae) in Straits of Malacca with description of a new species. Zookeys 545: 1–26. ⏕≀⛉Ꮫ㒊㛛 ከᵝᛶ⏕≀Ꮫศ㔝 ᑠட ୍ᘯ 㸦ᾏỈ⏝㸧 Ⓨ⾲ㄽᩥ Hagino, K., Young, J.R., Bown, P.R., Godrijan, J., Kulhanek, D.K., Kogame, K. and Horiguch, T. (2015) Re-discovery of a "living fossil" coccolithophore from the coastal waters of Japan and Croatia. Marine Micropaleontology 116: 28-37. Kogame, K., Rindi, F., Peters, A.F., and Guiry, M.D. (2015) Genetic diversity and mitochondrial introgression in Scytosiphon lomentaria (Ectocarpales, Phaeophyceae) in the north-eastern Atlantic Ocean. Phycologia 54: 367-374. Kogame, K., Ishikawa, S., Yamauchi, K., Uwai, S., Kurihara, A. and Masuda, M. (2015) Delimitation of cryptic species of the Scytosiphon lomentaria complex (Scytosiphonaceae, Phaeophyceae) in Japan, based on mitochondrial and nuclear molecular markers. Phycological Research 63: 167-177. Yaegashi, K., Yamagishi, Y., Uwai, S., Abe, T., Santiañez, W.J.E. and Kogame, K. (2015) Two species of the genus Acinetospora (Ectocarpales, Phaeophyceae) from Japan: A. filamentosa comb. nov. and A. asiatica sp. nov. Botanica Marina 58: 331-343. ᏛⓎ⾲ ᒣᓊ ᖾṇ࣭ᑠட ୍ᘯ࣭୕㍯ Ὀᙪ࣭ቑ⏣ 㐨ኵ㸸 ࢣࣈ࢝ࢲࢪࡼࡤࢀࡿ⣚⸴ࢲࢪᒓࡢ᪂✀ࡘ ࠸࡚ ᪥ᮏ⸴㢮Ꮫ➨ 40 ᅇ㸪2016 ᖺ 3 ᭶ 18ࠥ20 ᪥㸪᪥ᮏṑ⛉Ꮫ⏕ṑᏛ㒊㸦ᮾி㒔༓௦⏣༊㸧 Suttikarn Sutti࣭Masaya Tani࣭Yukimasa Yamagishi࣭ Tsuyoshi Abe ࣭ Kazuhiro Kogame: Chondria tenuissima in Japan: Is it misidentified as Chondria tenuissima (Rhodomelaceae, Rhodophyta)? ᪥ᮏ⸴㢮Ꮫ➨ 40 ᅇ㸪2016 ᖺ 3 ᭶ 18ࠥ20 ᪥㸪᪥ᮏṑ⛉Ꮫ⏕ṑᏛ㒊㸦ᮾி㒔༓௦⏣༊㸧 Wilfred John E. Santiañez࣭Kazuhiro Kogame: New additions to the seaweed flora of Japan: Hydroclathrus stephanosorus and H. tumulis (Scytosiphonaceae, Phaeophyceae) ᪥ᮏ⸴㢮Ꮫ➨ 40 ᅇ㸪2016 ᖺ 3 ᭶ 18ࠥ20 ᪥㸪᪥ᮏṑ⛉Ꮫ⏕ṑᏛ㒊㸦ᮾி㒔༓௦⏣༊㸧 − 27 − ⏕≀⛉Ꮫ㒊㛛 ከᵝᛶ⏕≀Ꮫศ㔝 ຍ⸨ ᚭ ᙜ◊✲ᐊ࡛ࡣ㸪ᐇ㦂⏕≀Ჷෆ࡛ࡉࡲࡊࡲ࡞㔝 ⏕ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࡢ⥅௦㣫⫱ࢆ⾜࠸㸪✀ࠎࡢ◊ ✲⏝ࡋ࡚࠸ࡿ㸬௨ୗ㣫⫱ࡋ࡚࠸ࡿ✀ཬࡧ◊ ✲≧ἣࢆグࡍ㸬 1. ⳦㣗ᛶࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࡢ㣫⫱㸸Drosophila ᒓࡢளᒓࡢ 1 ࡘ࡛࠶ࡿ Drosophila ளᒓࡣ㸪⳦ 㣗ᛶࡢࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࢆྵࡴࢢ࣮ࣝࣉࡀከ ࡃ▱ࡽࢀ࡚࠸ࡿ㸬≉ quinaria ✀⩌ࡤࢀ ࡿࢢ࣮ࣝࣉࡢ୍㒊ࡢ✀ࡣ㸪ࡢࢩࣙ࢘ࢪࣙ࢘ ࣂ࢚ࡗ࡚᭷ẘ࡞࢟ࣀࢥ⏤᮶ࡢẘ࡛࠶ࡿȘ ࣐ࢽࢳࣥཬࡧ࣎ࢸࣥ㓟⪏ᛶࢆᣢࡘࡀ ▱ࡽࢀ࡚࠸ࡿ㸬ࡋࡋ࡞ࡀࡽ㸪ࡇࡢẘ⪏ᛶࡀ ⳦㣗ᛶࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ᗈࡃࡳࡽࢀࡿᙧ㉁ ࡞ࡢ㸪ࡶࡋࡃࡣ quinaria ✀⩌୍⯡ⓗࡳ ࡽࢀࡿᙧ㉁࡞ࡢ㛵ࡋ࡚ࡣ༑ศ࡞㆟ㄽࡀࡉ ࢀ࡚࠸࡞࠸㸬ࡇࡢၥ㢟ࢆ᫂ࡽࡍࡿࡓࡵ㸪 quinaria ✀⩌࠾ࡼࡧࡑࢀ㏆⦕࡞ࢩࣙ࢘ࢪࣙ ࢘ࣂ࢚ࡽ㸪⳦㣗ᛶ࠾ࡼࡧ㠀⳦㣗ᛶࢩࣙ࢘ࢪ ࣙ࢘ࣂ࢚ࢆྜࢃࡏ࡚ 17 ✀㣫⫱ࡋ㸪࢟ࣀࢥẘ⪏ ᛶࡢ᭷↓ࢆ᳨ドࡋ࡚࠸ࡿ㸬2015 ᖺᗘࡣ㸪⳦㣗 ᛶࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ 5 ✀㸪㠀⳦㣗ᛶࢩࣙ࢘ ࢪࣙ࢘ࣂ࢚ 2 ✀㛵ࡋ࡚࣎ࢸࣥ㓟ᑐࡍࡿ ẘ⪏ᛶࡢᐇ㦂ࢆ⾜ࡗࡓ㸬ࡑࡢ⤖ᯝ㸪⳦㣗ᛶ 㠀⳦㣗ᛶࢩࣙ࢘ࢪࣙ࢘ࣂ࢚㛫࠾ࡅࡿ⮴Ṛ⋡ ᭷ពᕪࢆぢฟࡍࡇࡀฟ᮶࡞ࡗࡓ㸬ࡇࡢ ࡇࡣ㸪࣎ࢸࣥ㓟ᑐࡍࡿẘ⪏ᛶࡀ㸪 quinaria ✀⩌ࡑࢀ㏆⦕࡞⳦㣗ᛶཬࡧ㠀⳦ 㣗ᛶࡢࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ᗈࡃಖᣢࡉࢀ࡚࠸ ࡿྍ⬟ᛶࢆ♧၀ࡍࡿ㸬 2. Lordiphosa collinella Lordiphosa sp. aff. collinella ࡢ㣫⫱ᐇ㦂㸸L. collinella ࡣᮾࢪ ᗈࡃ⏕ᜥࡍࡿⲡᮏ㣗ᛶࡢࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ ࡢ୍✀࡛࠶ࡿ㸬୍᪉㸪ᾏ㐨࠾࠸࡚ࡣࠊࡇ ࢀᙧែⓗ㓞ఝࡍࡿ L. sp. aff. collinella ࡢᏑ ᅾࡀㄆ㆑ࡉࢀ࡚࠸ࡿ㸬ᚑ᮶㸪ࡇࡢ 2 ✀ࡣᗈⴥ ᶞᯘࡢୗᒙ⏕࠼ࡿ᳜≀ࡢ⩌ⴠ࡞ࡽ᥇ 㞟ࡉࢀࡿࡉࢀ࡚࠾ࡾ㸪⏕ᜥ⎔ቃࡁ࡞㐪 ࠸ࡣ࡞࠸ࡶࡢ⪃࠼ࡽࢀ࡚ࡁࡓ㸬ࡋࡋ࡞ࡀ ࡽ㸪᭱㏆ࡢᡃࠎࡢ᥇㞟ㄪᰝ࠾࠸࡚㸪ࣇࢵ࢟ ࢯ࢘࠸࠺ᖖ⥳ࡢపᮌࡢ⩌ⴠࢆࢫ࣮࢘ࣆࣥ ࢢࡍࡿ㸪L. collinella ࡣࢇ᥇㞟ࡉࢀ࡞ ࠸ࡀ㸪L. sp. aff. collinella ࡣᩘከࡃ᥇㞟ࡉࢀࡿ ࡇࡀศࡗࡓ㸬ࡑࡇ࡛ᡃࠎࡣ㸪L. sp. aff. collinella ࡀࣇࢵ࢟ࢯ࢘㣗ⲡࢆᣑࡋࡓ࠸ ࠺௬ㄝࢆ❧࡚㸪2 ✀ࡢࣇࢵ࢟ࢯ࢘ᑐࡍࡿᡂ ࡢ⏘༸㑅ዲᛶࡸᗂࡢ㣗ⲡ⏝⬟ຊࢆ᫂ࡽ ࡍࡿࡓࡵࡢ㣫⫱ᐇ㦂ࢆணഛⓗ⾜ࡗࡓ㸬ࡑ ࡢ⤖ᯝ㸪ࡇࡢ 2 ✀ࡢᗂࡢ㣗ⲡ⏝⬟ຊ᫂ 3. ☜࡞ᕪࡣぢࡽࢀ࡞࠸ࡶࡢࡢ㸪ࣇࢵ࢟ࢯ࢘ࡢⴥ ࡢ㞤ᡂࡢ⏘༸㑅ዲᛶࡁ࡞㐪࠸ࡀぢࡽ ࢀࡿࡇࡀศࡗࡓ㸬 Drosophila maculinotata ࡢ⣔⤫⥔ᣢ㸸ᮏ✀ࡣ᪥ ᮏᅛ᭷✀࡛࠶ࡾ㸪ᙧែᇶ࡙ࡃ◊✲࡛ࡣ Drosophila ᒓ Drosophila ளᒓྵࡲࢀࡿ⪃ ࠼ࡽࢀ࡚࠸ࡿ㸬୍᪉㸪㐣ཤࡢ DNA ሷᇶ㓄ิࢆ ⏝࠸ࡓศᏊ⣔⤫Ꮫⓗ◊✲࡛ࡣ㸪ูᒓ࡛࠶ࡿ Idiomyia ᒓࡸ Scaptomyza ᒓࡼࡾ㏆⦕࡛࠶ࡿ ྍ⬟ᛶࡀ♧၀ࡉࢀ࡚࠸ࡿࡀ㸪ヲ⣽࡞⣔⤫ⓗ ⨨ࡣ᫂࡞ࡲࡲ࡛࠶ࡿ㸬ࡲࡓ㸪ᮏ✀ࡣᅜෆࡢ ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࢫࢺࢵࢡࢭࣥࢱ࣮බ㛤ࡉ ࢀ࡚࠸ࡿ㣫⫱ᰴࡀᏑᅾࡋ࡞࠸㸬ࡼࡗ࡚㸪ሷᇶ 㓄ิሗྲྀᚓཬࡧ㣫⫱ᰴࡢ⥔ᣢࢆ┠ⓗࡋ㸪 ᮏ✀ࡢ⥅௦㣫⫱ࢆ⾜ࡗ࡚࠸ࡿ㸬 ࣭ㄽᩥⓎ⾲㸸 Hiruta, S., Kobayashi, N., Katoh, T., and Kajihara, H. Molecular phylogeny of Cypridoid freshwater ostracods (Crustacea: Ostracoda), inferred from 18S and 28S rDNA sequences. Zoological Science (in press). ࣭ᏛⓎ⾲㸸 ୕ࢶᶫᆂ㸪⚟⏣ὒஅ㸪ᡞ⏣ṇ᠇㸪ຍ⸨ᚭ㸸Lordiphosa collinella Lordiphosa sp. aff. collinella ࡢ㑇ఏⓗศ 㸬 ᪥ᮏ㐍Ꮫ➨ 17 ᅇ㸪2015 ᖺ 8 ᭶ 20 ᪥㸪 ୰ኸᏛᚋᴦᅬ࢟ࣕࣥࣃࢫ㸦ᩥி༊㸧 㸬 ⚟⏣ὒஅ㸪ᡞ⏣ṇ᠇㸪ຍ⸨ᚭ㸸⳦㣗ᛶࢩࣙ࢘ࢪࣙ ࢘ࣂ࢚ࡢ⣔⤫㛵ಀ⳦㣗ᛶࡢ㉳※ࡢ᥎ᐃ㸬᪥ᮏ㐍 Ꮫ➨ 17 ᅇ㸪2015 ᖺ 8 ᭶ 20 ᪥㸪୰ኸᏛ ᚋᴦᅬ࢟ࣕࣥࣃࢫ㸦ᩥி༊㸧㸬 ⸨ᒣ┤அ㸪ຍ⸨ ᚭ㸪ᑠ㊰స㸪⳥⏣ᑦ࿃㸪ᮧ⏣ᣅ ஓ㸪Sih Kahono㸪Rosli Hashim㸪Yaowaluk Monthum㸪 ∦ ᬕ㞝㸸ᮾ༡ࢪ⏘ࡢࢼࢫ⛉㣗ࢸࣥࢺ࣒࢘ࢩ ࡀ♧ࡍ࣐࣓⛉᳜≀ᦤ㣗⬟ຊ㸬᪥ᮏ᪻Ꮫ➨ 76 ᅇ ➨ 60 ᅇ᪥ᮏᛂ⏝ື≀᪻Ꮫ ྜྠ㸪 2016 ᖺ 3 ᭶ 28 ᪥㸪㜰ᗓ❧Ꮫ୰ⓒ⯉㫽࢟ࣕࣥ ࣃࢫ㸦ሜᕷ㸧 㸬 Ꮫ㝔㎰Ꮫ◊✲㝔 ᇶ┙◊✲㒊㛛 ⏕≀㈨※⛉Ꮫศ㔝 ⛅ඖ ಙ୍ 㸦Ⳣ㔝Ⰻ୍࣭ᅵᒇ㤶⧊࣭ᐑᓮᚿ࣭ΎỈ㍜㸧 ⏝≧ἣ࣭◊✲ᡂᯝ ᡃࠎࡣ㛗ᖺΏࡾ㸪▷⩟ᛶ࡛⛣ື⬟ຊஈࡋ࠸㸪 ࢧࢵ࣏ࣟࣇ࢟ࣂࢵࢱ Podisma sapporensis ཬࡧ㸪࣑ − 28 − ࢝ࢻࣇ࢟ࣂࢵࢱ Parapodisma mikado ࢆᮦᩱ⏝࠸㸪 㞟ᅋ㛫ࡢ㓄അ⾜ືࡢศࡢ㐍ࣉࣟࢭࢫࡸ⏕Ṫ㝸 㞳ᶵᵓࡢゎ᫂ྲྀࡾ⤌ࢇ࡛࠸ࡿ㸬ᮏᖺᗘࡣ㸪࣓ࢫ ᑿჾᕥྑ㠀ᑐ⛠࡞㙾ീᆺ㸦ᕥྑᆺ⌧㇟㸧 ࢆᣢࡘ࣑࢝ࢻࣇ࢟ࣂࢵࢱ࠾࠸࡚㸪ࡇࡢᆺࡀ⥔ ᣢࡉࢀ࡚࠸ࡿ⌮⏤ࢆ㸪ᑿ⾜ືࡸ⢭Ꮚ㍺㏦㔞ࡢほ Ⅼࡽ᳨ウࡋࡓ㸬 ࣑ࠗ࢝ࢻࣇ࢟ࣂࢵࢱࡢ࣓ࢫᑿჾࡢ㙾ീᆺࡀ ᑿ⾜ືࡸ⢭Ꮚ㍺㏦࠼ࡿᙳ㡪࠘ ࡛᪻ࡣཱྀჾࡸᑿჾࡀ㠀ᑐ⛠࡞✀ࡀࡋࡤࡋࡤぢ ࡽࢀࡿ㸬㠀ᑐ⛠࡞ᑿჾࢆᣢࡘ✀ࡢ୍㒊ࡣ㸪ᑿ ჾࡀᕥྑ㠀ᑐ⛠࡞㙾ീᆺ㸦ᕥྑᆺ⌧㇟㸧࡞ ࡗ࡚࠸ࡿ㸬ࡇࡢᆺࡣ㸪㏻ᖖ㸪࢜ࢫᑿჾ࡛ほᐹ ࡉࢀ㸪࣓ࢫᑿჾ࡛ࡢሗ࿌ࡣ㠀ᖖ㝈ࡽࢀ࡚࠸ ࡿ㸬ᡃࠎࡀࡇࢀࡲ࡛ࡢ୍㐃ࡢ◊✲࡛ᮦᩱࡋ࡚࠸ ࡿ࣑࢝ࢻࣇ࢟ࣂࢵࢱࡣ㸪࢜ࢫᑿჾ㠀ᑐ⛠ᛶ ࡣぢࡽࢀ࡞࠸ࡀ㸪࣓ࢫᑿჾࡢᑿᄞ࠸࠺ჾᐁ ࡢ୍㒊㸦㦵∦㸧ᕥྑ㠀ᑐ⛠࡞㙾ീᆺࡀᏑᅾࡍ ࡿࡇࡀ▱ࡽࢀ࡚࠸ࡿ㸬ࡇࡢᆺࡀ㸪࣑࢝ࢻࣇ࢟ ࣂࢵࢱࡢ㞟ᅋ㛫࡛ࡢ⛬ᗘ⥔ᣢࡉࢀ࡚࠸ࡿࡢ㸪 ࡲࡓ㸪㞟ᅋ㛫࡛ศࡋ࡚࠸ࡿሙྜࡣ㸪ࡑࡢศࡀ 㞟ᅋ㛫ࡢ⏕Ṫ㝸㞳ᐤࡋ࡚࠸ࡿྍ⬟ᛶࡘ࠸࡚㸪 ᑿჾࡢゎ๗ࡸィ 㸪⾜ືほᐹ㸪⢭Ꮚ㍺㏦㔞ࡢ ᐃ࡞ࢆ⾜࠸㸪᫂ࡽࡍࡿࡇࢆヨࡳࡓ㸬 ᾏ㐨ෆࡢ㸵㞟ᅋࢆ⏝࠸࡚ㄪᰝࡋࡓ⤖ᯝ㸪 ࡚ࡢ㞟ᅋ࡛㸪࣓ࢫᑿჾᕥྑ㠀ᑐ⛠࡞㙾ീᆺ ࡀㄆࡵࡽࢀ㸪ࡑࡢᕥྑᛶࡢྜࡣ㸪࠾ࡼࡑᕥ㸯㸸 ྑ㸰࡛࠶ࡗࡓ㸬ㄪᰝࡋࡓ㸵㞟ᅋࡢෆࡢ㸯㞟ᅋ㸦ᒾ ぢἑ㞟ᅋ㸧࡛ࡣ㸪ᕥྑᛶࡢྜࡣ㸱ᖺ㛫㐃⥆࡛ኚ ࡋ࡞ࡗࡓ㸬ࡇࡢࡇࡽ㸪࣑࢝ࢻࣇ࢟ࣂࢵࢱ ࡢ࣓ࢫᑿჾぢࡽࢀࡿᕥྑ㠀ᑐ⛠࡞㙾ീᆺ ࡑࡢᕥྑᛶࡢྜࡣ㸪࠶ࡿ⛬ᗘᏳᐃⓗಖࡓࢀ࡚ ࠸ࡿࡇࡀ♧၀ࡉࢀࡓ㸬 ࣑࢝ࢻࣇ࢟ࣂࢵࢱࡢᑿࡣ㸪࢜ࢫࡀ࣓ࢫ࣐ ࢘ࣥࢺࡋ㸪⮬ศࡢ⭡㒊ࢆ࣓ࢫࡢ⭡㒊ࡢྑഃࡶࡋࡃ ࡣᕥഃࡽࡗ࡚㸪ᑿჾྠኈࢆ᥋ྜࡉࡏࡿࡇ ࡛ᡂ❧ࡍࡿ㸬᭱㏆ࡢ◊✲࠾࠸࡚㸪ྠࡌࣂࢵࢱ⛉ ᒓࡍࡿࢥࣂࢿࢼࢦ Oxya yezoensis ࡛ࡣ㸪࢜ࢫ ࡣᑿࡢ㝿ᚲࡎྑഃࡽ⭡㒊ࢆࡿ࠸࠺ࡇ ࡀሗ࿌ࡉࢀ࡚࠸ࡿ㸬ࡋࡋ࡞ࡀࡽ㸪࣑࢝ࢻࣇ࢟ࣂ ࢵࢱࡢ࣓ࢫᑿჾࡣ᫂☜࡞ᕥྑᛶࡀᏑᅾࡍࡿ ࡶࢃࡽࡎ㸪ᑿᐇ㦂࠾࠸࡚㸪࣓ࢫᑿჾࡢ ᕥྑᛶࡣ㸪ᑿࡢ㝿࢜ࢫࡀ⭡㒊ࢆࡿ᪉ྥᙳ 㡪ࢆ࠼࡚࡞࠸ࡇࡀ᫂ࡽ࡞ࡗࡓ㸬⌧ᅾ㸪࣑ ࢝ࢻࣇ࢟ࣂࢵࢱࡢ࣓ࢫᑿჾࡢᕥྑ㠀ᑐ⛠࡞㙾ീ ᆺࡀᕥ㸯㸸ྑ㸰ࡢྜ࡛⥔ᣢࡉࢀ࡚࠸ࡿ⌮⏤ ࡘ࠸࡚㸪ᑿᐇ㝿㍺㏦ࡉࢀࡓ⢭Ꮚ㔞ࢆィ ࡋ㸪࣓ࢫᑿჾࡢᕥྑᛶ㸪ᑿ୰ࡢ࢜ࢫࡢ⭡㒊ࡢ ᪉ྥᛶ㸪⢭Ꮚ㍺㏦㔞ࡢ㛫ఱࡽࡢ┦㛵ࡀぢࡽࢀ ࡿ࡞㸪࠸ࡃࡘࡢ␗࡞ࡿࣉ࣮ࣟࢳࡽ᭦࡞ ࡿゎᯒసᴗࢆ㐍ࡵ࡚࠸ࡿ㸬 ㄽᩥ SHIMIZU D., Sugano Y., Tsuchiya-Suzuki K., Ito G. & Akimoto S. Dimorphism of right-left asymmetry in the female genitalia of the brachypterous grasshopper Parapodisma mikado (Orthoptera, Acrididae) Entomological Science (in press) Ꮫ⾡Ⓨ⾲ ࢩ࣏ࣥࢪ࣒࢘ Sugano Y., Tuchiya-Suzuki K. & Akimoto S. Biogeographic variation in reproductive traits and development of cryptic reproductive isolation between local populations in a grasshopper, Podisma sapporensis. (Language: English) ➨ 31 ᅇಶయ⩌⏕ែᏛ㸪2015 ᖺ 10 ᭶ 12 ᪥㸪 ㈡┴❧Ꮫ㸦ᙪ᰿ᕷ㸧 ᑠ㞟 ᅵᒇ㤶⧊㸪Ⳣ㔝Ⰻ୍㸪⛅ඖಙ୍㸪㕥ᮌᬛஅ ࠗ㞤ࡼࡿ⢭Ꮚࡢ㑅ᢥࡽ⏕ࡌࡿ㞃ⶸࡉࢀࡓ⏕Ṫ ⓗ㝸㞳㸸ࢧࢵ࣏ࣟࣇ࢟ࣂࢵࢱࡢ࠘ ᪥ᮏ᪻Ꮫ➨ 75 ᅇ㸪2015 ᖺ 9 ᭶ 20 ᪥㸪 ᕞᏛ⟽ᓮ࢟ࣕࣥࣃࢫ㸦⚟ᒸᕷ㸧 ᇶ┙◊✲㒊㛛 ᛂ⏝⏕⛉Ꮫศ㔝 㧗㔝 㡰ᖹ ᳜≀ࡣ᰿࡛࣑ࢿࣛࣝ㸦↓ᶵᰤ㣴⣲㸧ࢆ྾࠸ୖࡆࠊ యෆࢆᚠ⎔ࡉࡏ࡚⏝ࡍࡿࠋ᳜≀ࡀ࣑ࢿࣛࣝࢆຠ ⋡ⓗ⋓ᚓࡋ⏝ࡍࡿࡓࡵࡣࠊᵝࠎ࡞⣽⬊ࡢ⏕ య⭷࠾࠸࡚࣑ࢿࣛࣝࡢ⭷㏱㐣ࢆಁ㐍ࡍࡿࢱࣥࣃ ࢡ㉁<࣑ࢿࣛࣝ㍺㏦య>ࡀ㐺ᮦ㐺ᡤ㓄⨨ࡉࢀࡿࡇ ࡀ㔜せ࡛࠶ࡿࠋ⚾ࡓࡕࡣࠊࢩࣟࢾࢼࢬࢼࢆࣔ ࢹࣝࡋ࡚⏝࠸ࠊ᳜≀⣽⬊⭷࠾ࡅࡿ࣑ࢿࣛࣝ㍺ ㏦యࡢ✚೫ᅾࡢไᚚᶵᵓࢆ⌮ゎࡋࠊ᳜≀ࡢ࣑ ࢿࣛࣝ྾࣭⛣⾜ࢆ㐺ษࢥࣥࢺ࣮ࣟࣝࡍࡿᢏ⾡ ࡢ㛤Ⓨࢆ┠ᣦࡋ࡚࠸ࡿࠋᮏᖺᗘᚓࡓ࡞ᡂᯝࢆ ⤂ࡍࡿࠋ 1, ࣍࢘㓟ࢳࣕࢿࣝ NIP5;1 ࡣ᰿ࡢ⾲㠃ࡢ⣽⬊ࡢ⣽ ⬊⭷࠾࠸࡚ࠊᅵተࡼࡾ೫ᅾࡍࡿࠋ೫ᅾᛶࡣ࣍ ࢘㓟ࡢ྾࠾࠸࡚㔜せ࡞ᙺࢆᯝࡓࡍ⪃࠼ࡽ ࢀࡿࠋᮏᖺᗘࡣࠊ೫ᅾࡢ⏕⌮Ꮫⓗព⩏ࡘ࠸࡚ゎ ᯒࢆ㐍ࡵࠊ೫ᅾᛶࡀຠ⋡ⓗ࡞࣍࢘㓟྾ᆅୖ㒊 ࡢ⛣⾜㔜せ࡛࠶ࡿࡇࢆ᫂ࡽࡋࡓࠋࡲࡓࠊ NIP5;1 ࡀᑠ⬊యࡽࢦࣝࢪ㏦ࡽࢀࡿ㐣⛬㛵ࢃ ࡿࢱࣥࣃࢡ㉁ࡢᒁᅾゎᯒࢆ㐍ࡵࢦࣝࢪᒁᅾࡍࡿ − 29 − ⪃࠼ࡽࢀࡿ⤖ᯝࢆᚓࡓࠋ 2, ࣍࢘㓟ฟᆺ㍺㏦య BOR1 ࡣ᰿ࡢ⣽⬊⭷࠾࠸ ࡚ NIP5;1 ࡣᑐ୰ᚰᰕࡼࡾ㸦᰿ࡢ୰ᚰ᪉ྥ㸧 ೫ᅾࡍࡿࠋBOR1 ࡢ೫ᅾᛶࡣ࣍࢘㓟ࡢ᳜≀యෆ ࡛ࡢ㍺㏦᪉ྥࢆỴᐃࡍࡿ㔜せ࡞⌧㇟⪃࠼ࡽࢀࡿࠋ ୍᪉ࠊBOR1 ࡣ㧗⃰ᗘࡢ࣍࢘㓟ᛂ⟅ࡋ࡚ᑠ⬊㍺ ㏦⣔ࢆࡋ࡚ᾮ⬊㏦ࡽࢀ࡚ศゎࡉࢀࡿࠋࡇࢀࡣ ࣍࢘⣲ࡢ㐣✚ࢆ㜵ࡄࡓࡵ㔜せ࡞⌧㇟⪃࠼ ࡽࢀࡿࠋᮏᖺᗘࡣᑠ⬊㍺㏦࠾࠸࡚✚ࡳⲴࢱࣥࣃ ࢡ㉁ࡢ㑅ูࢆ⾜࠺ࢲࣉࢱ࣮ࢱࣥࣃࢡ㉁」ྜయࡢ BOR1 ࡢ⣽⬊ෆ㍺㏦࠾ࡅࡿᙺࡘ࠸࡚ゎᯒࡋࠊ BOR1 ࡢ೫ᅾᛶࢆ⥔ᣢࡍࡿࡓࡵࡢ࢚ࣥࢻࢧࢺ࣮ ࢩࢫࠊ࣍࢘㓟ᛂ⟅ࡋࡓᾮ⬊㍺㏦ࡑࢀࡒࢀാ ࡃࢲࣉࢱ࣮ࢱࣥࣃࢡ㉁」ྜయࢆぢฟࡋࡓࠋ 3, ࣍࢘㓟ࢺࣛࣥࢫ࣏࣮ࢱ࣮BOR1 ࡀ㧗⃰ᗘࡢ࣍࢘ 㓟ᛂ⟅ࡋ࡚ศゎࡉࢀࡿ㝿ࡢ࣍࢘㓟ࢭࣥࢩࣥࢢࡢ ࣓࢝ࢽࢬ࣒ࡘ࠸࡚ゎᯒࡋࡓࠋBOR1 ࡢከᩘࡢ ࣑ࣀ㓟ኚ␗ࢆゎᯒࡋࠊศゎᛂ⟅ࡢపୗࡀ㉳ࡇࡿࡶ ࡢࡢ࣍࢘㓟㍺㏦άᛶࡸ⣽⬊⭷ෆ೫ᅾᛶᙳ㡪ࡋ࡞ ࠸ኚ␗ࢆ」ᩘྠᐃࡋࡓࠋࡇࢀࡽࡢ࣑ࣀ㓟ࡣ࣍࢘ 㓟ࢭࣥࢩࣥࢢ㛵ࡍࡿྍ⬟ᛶࡀ㧗࠸ࠋ 4, ᳜≀ࡢྛ⣽⬊ෆ࠾ࡅࡿ࣍࢘㓟⃰ᗘࢆẚ㍑ࡍ ࡿࡓࡵࠊ⣽⬊ෆ࣍࢘㓟ࢭࣥࢧ࣮ࡢ㛤Ⓨࢆ㐍ࡵࡓࠋ ⺯ගࢆ⏝࠸ࡓ࣍࢘㓟ࢭࣥࢧ࣮࡛ࡣࠊ㧗ศゎ⬟࡛⣽ ⬊ࡈࡢ࣍࢘㓟⃰ᗘࢆぢ✚ࡶࡿࡇࢆྍ⬟ࡋࡓࠋ Ⓨගࢆ⏝࠸ࡓ࣍࢘㓟ࢭࣥࢧ࣮࡛ࡣࠊ㧗㛫ศゎ⬟ ࡛࣍࢘㓟྾ࡢࢱ࣒ࢥ࣮ࢫࢆ㏣࠺ࡇࢆྍ⬟ ࡋࡓࠋࡇࢀࡽࢆ⏝࠸࡚ྛ✀ኚ␗ᰴ࠾ࡅࡿ࣍࢘㓟 ㍺㏦ࡢゎᯒࢆ⾜ࡗࡓࠋ 5, ࣍࢘㓟ࢺࣛࣥࢫ࣏࣮ࢱ࣮BOR1 ࡢ೫ᅾᛶ࣍࢘ 㓟ᛂ⟅ᛶࡢ୧᪉ࢆᙅࡵࡓ BOR1 ࢆᜏᖖⓗⓎ⌧ࡍ ࡿᙧ㉁㌿ࢩࣟࢾࢼࢬࢼࡀ㐣࣍࢘㓟⪏ᛶࢆ♧ ࡍࡇࢆぢฟࡋࡓࠋ⏕⌮Ꮫⓗ࡞ゎᯒࡼࡾࠊᮏᙧ ㉁㌿ᰴ࡛ࡣྛ⤌⧊ࡢྛ⣽⬊࠾࠸࡚⣽⬊እ࣍ ࢘㓟ࢆฟࡍࡿࡇࡼࡾ⣽⬊㉁ࢆᏲࡾࠊ㐣⪏ ᛶࡀᚓࡽࢀࡓ⪃࠼ࡽࢀࡓ (Wakuta et al. 2016)ࠋ ௨ୖࡢ◊✲ࡣࠊࢤࣀ࣒ࢲࢼ࣑ࢡࢫࢭࣥࢱ࣮ࡢ ᨭࡼࡗ࡚ከᩘࡢࢩࣟࢾࢼࢬࢼᙧ㉁㌿⣔⤫ ࠾ࡼࡧኚ␗⣔⤫ࢆᢅ࠺ࡇࡀ࡛ࡁ࡚ጞࡵ࡚ྍ⬟ ࡞ࡗࡓࡶࡢ࡛࠶ࡾࡲࡍࠋᮏᖺᗘࢆࡶࡗ࡚⚾ࡣ ࡼࡾ㌿ฟࡋࡲࡍࡀࠊࡇࢀࡲ࡛◊✲ࢆᨭ࠼࡚ୗࡉࡗ ࡓࢭࣥࢱ࣮㛵ಀ⪅ࡢⓙᵝᚰࡼࡾឤㅰ⏦ࡋୖࡆࡲ ࡍࠋ ㄽᩥ Wang, S., Ito, T., Uehara, M., Naito, S., and Takano, J. (2015) UDP-d-galactose synthesis by UDP-glucose 4-epimerase 4 is required for organization of the trans-Golgi network/early endosome in Arabidopsis thaliana root epidermal cells. Journal of Plant Research. 128:863-873. Barberon, M., Engelbertus, J., Vermeer, M., De Bellis, D., Wang, P., Naseer, S., Andersen, T. G., Humbel, B. M., Nawrath, C., Takano, J., Salt, D. E., Geldner, N. (2015) Adaptation of Root Function by Nutrient-Induced Plasticity of Endodermal Differentiation. Cell 164, 1–13. Wakuta, S., Fujikawa, T., Naito, S., and Takano, J. (2016) Tolerance to Excess-Boron Conditions Acquired by Stabilization of a BOR1 Variant with Weak Polarity in Arabidopsis. Frontiers in Cell and Developmental Biology 4, 1–11. ᏛⓎ⾲ Wang, S., Mitani-Ueno, N., Ma, JF., Naito, S., Takano, J.: Phosphorylation-mediated polar localization of a boric acid channel is required for efficient uptake of boron in Arabidopsis thaliana. 13th ICOBTE, 2015 ᖺ 7 ᭶ 15 ᪥, ⚟ᒸᅜ㝿㆟ሙ (⚟ᒸᕷ). Yoshinari,A., Kurata,T., Sakamoto,T., Naito, S., Takano, J.: AP2-dependent and independent endocytosis distinctly regulate polar localization and degradation of a borate transporter BOR1 in Arabidopsis thaliana. 13th ICOBTE, 2015 ᖺ 7 ᭶ 15 ᪥, ⚟ᒸᅜ㝿㆟ሙ (⚟ᒸᕷ). Ogino, Y., Yoshinari,A., Wakuta,S., Naito, S., Takano, J.: Mechanisms for boron-dependent vacuolar trafficking of a boric acid/borate transporter AtBOR1. 13th ICOBTE, 2015 ᖺ 7 ᭶ 13-16 ᪥(࣏ࢫࢱ࣮),⚟ᒸ ᅜ㝿㆟ሙ (⚟ᒸᕷ). ஂ⏣┿ྖࠊ⸨ᕝဴᖹࠊෆ⸨ဴࠊ㧗㔝㡰ᖹ: ࣍࢘ 㓟ࢭࣥࢧ࣮ࡼࡿ᳜≀⤌⧊ෆ࣍࢘㓟ศᕸࡢゎᯒ. ᅵተ⫧ᩱᏛி㒔ࠊ2015 ᖺ 9 ᭶ 9-11 ᪥, ி㒔 Ꮫ (ி㒔ᕷ). Ⲷ㔝 ⏤㤶ࠊྜྷᡂ 㸪ஂ⏣ ┿ྖ㸪ෆ⸨ ဴ㸪㧗 㔝 㡰ᖹ: ࢩࣟࢾࢼࢬࢼ࣍࢘㓟㍺㏦య BOR1 ࡼ ࡿ࣍࢘㓟ࢭࣥࢩࣥࢢࡢྍ⬟ᛶ. ᅵተ⫧ᩱᏛி㒔 ࠊ2015 ᖺ 9 ᭶ 9-11 ᪥, ி㒔Ꮫ (ி㒔ᕷ). ୰ᮧ ಇࠊୖཎ ㈗,ෆ⸨ ဴ,㧗㔝 㡰ᖹ: ࢩࣟ ࢾࢼࢬࢼ⣽⬊⭷ᒁᅾᆺ࣍࢘㓟ࢳࣕࢿࣝ NIP5;1 ࡢ ER exit ᚲせ࡞ᅉᏊࡢྠᐃ. ᅵተ⫧ᩱᏛி㒔 ࠊ2015 ᖺ 9 ᭶ 9-11 ᪥, ி㒔Ꮫ (ி㒔ᕷ). Wang, S., Mitani-Ueno, N., Ma, JF., Naito, S., Takano, J.: Polar Localization of a Boric Acid Channel NIP5;1 is Mediated by Phosphorylation and Required for Efficient Uptake of Boron in Arabidopsis thaliana. ➨ − 30 − 57 ᅇ᪥ᮏ᳜≀⏕⌮Ꮫᖺࠊ2016 ᖺ 3 ᭶ 20 ᪥ࠊᒾ ᡭᏛୖ⏣࢟ࣕࣥࣃࢫ (┒ᒸᕷ).. ྜྷᡂࠊ⸨ᮏ ඃ,ኳ㔝 ኴ㑻,ᒣᒸ ᑦᖹ,ᔱ⏣ ▱⏕, すᮧ ࠸ࡃࡇ,ୖ⏣ ㈗ᚿ,ෆ⸨ ဴ,㧗㔝 㡰ᖹ㸸BOR1 ࡢ⣽⬊⭷ୖ࡛ࡢ೫ᅾࡣࢡࣛࢫࣜࣥࢲࣉࢱ࣮ AP2 ࡀᚲ㡲࡛࠶ࡿࡶࡢࡢࠊ࣍࢘⣲ᛂ⟅ࡋࡓศゎ AP2 ࡣせ࡛࠶ࡿ. ➨ 57 ᅇ᪥ᮏ᳜≀⏕⌮Ꮫ ᖺࠊ2016 ᖺ 3 ᭶ 20 ᪥ࠊ ᒾᡭᏛୖ⏣࢟ࣕࣥࣃࢫ (┒ ᒸᕷ).. ୰ᮧ ಇࠊୖཎ ㈗ࠊ➉ᮧ 㥴,▼㯮 ⾨,⚄㇂ ᓅὒ,⸨ཎ ᚭ,ෆ⸨ ဴ,㧗㔝 㡰ᖹ㸸࣍࢘㓟ࢳࣕࢿࣝ ࡢ ER exit 㔜せ࡞ᅉᏊ KNS3/SPOT1 ࡢྠᐃ. ➨ 57 ᅇ᪥ᮏ᳜≀⏕⌮Ꮫᖺࠊ2016 ᖺ 3 ᭶ 18-20 ᪥ (࣏ࢫࢱ࣮)ࠊᒾᡭᏛୖ⏣࢟ࣕࣥࣃࢫ (┒ᒸᕷ). Ⲷ㔝 ⏤㤶ࠊ୕ᾆ ᘪె,ஂ⏣ ┿ྖ,ෆ⸨ ဴ,㧗㔝 㡰ᖹ㸸࣍࢘㓟㍺㏦య BOR1 ࡢᾮ⬊㍺㏦ไᚚ㔜せ ࡞࣑ࣀ㓟ṧᇶࡢྠᐃᶵ⬟ゎᯒ. ➨ 57 ᅇ᪥ᮏ᳜ ≀⏕⌮Ꮫᖺࠊ2016 ᖺ 3 ᭶ 18-20 ᪥(࣏ࢫࢱ࣮)ࠊ ᒾᡭᏛୖ⏣࢟ࣕࣥࣃࢫ (┒ᒸᕷ). ᇶ┙◊✲㒊㛛 ␆⏘⛉Ꮫศ㔝 ᕝཎ Ꮫ ᮏᖺᗘࡣࠊࢤࣀ࣒ࢲࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮ࢆ ⏝ࡍࡿࡇࡼࡾࠊ့ங㢮ึᮇ⬇Ⓨ⏕ࡢ࣓࢝ࢽ ࢬ࣒ࡢゎ᫂ࠊಶయⓎ⏕࠾ࡅࡿ࣑ࢺࢥࣥࢻࣜᶵ ⬟ࡢ㔜せᛶ㛵ࡍࡿ▱ぢࢆᚓࡓࠋ့ங㢮ࡢಶయⓎ ⏕࠾ࡅࡿ᭱ึࡢศࡣࠊ࢘ࢩࡢሙྜ㸪ཷ⢭ᚋ⣙ 6 ᪥┠ࡳࡽࢀࡿࠋࡑࢀࡲ࡛ᆒ୍ከ⬟ᛶࢆಖᣢ ࡋ࡚࠸ࡓ⣽⬊㞟ᅋࡀ 6 ᪥┠ࡣ᱓ᐇ⬇࡞ࡾ㸪ࡑ ࡢᚋእഃࢆໟࡴࠊᑗ᮶ࠊ⫾┙࡞ࡢ⫾Ꮚ௨እ ࢆᙧᡂࡍࡿᰤ㣴እ⬇ⴥ(trophectoderm ; TE)ࠊᑗ᮶ࠊ ⫾Ꮚࢆᙧᡂࡍࡿෆ㒊⣽⬊ሢ(inner cell mass ; ICM)༊ูࡉࢀࡿࡼ࠺࡞ࡿࠋᡃࠎࡣ࢘ࢩ⬇ࢆ⏝ ࠸࡚ ICM TE ࡢ⥙⨶ⓗ࡞㑇ఏᏊⓎ⌧ࢆㄪⓎ⌧ ࡢᕪ㐪ࢆ᳨ฟࡍࡿࡇ࡛ࠊࡑࢀࡒࢀ㒊≉␗ⓗ ࡞㑇ఏᏊⓎ⌧ࢆ♧ࡍ㑇ఏᏊ⩌ࢆྠᐃࡋࡓࠋೃ⿵㑇 ఏᏊࡢ୰ࡽࠊNASP ࠾ࡼࡧ CIITA ὀ┠ࡋࠊᶵ ⬟ ゎ ᯒ ࢆ ヨ ࡳ ࡓ ࠋ NASP (nuclear autoantigenic sperm protein)ࡣ࣮ࣜࣥ࢝ࣄࢫࢺࣥ H1 ⤖ྜࡋࠊ H1 ࡢ᰾ෆ⛣⾜ࡸ⨨ᚲ㡲ࡢศᏊࢩࣕ࣌ࣟࣥࢱ ࣥࣃࢡ㉁࡛࠶ࡿࠋCIITA ࡣࠊ㌿άᛶ㡿ᇦ࡛࠶ࡿ 㓟ᛶ㡿ᇦࠊ4 ࡘࡢࣟࢩࣥࣜࢵࢳࣜࣆ࣮ࢺ (leucine-rich repeats; LRRs) GTP ⤖ྜ㡿ᇦࢆᣢࡘࠋ ࡲࡓ㸪ࢱࣥࣃࢡ㉁ࡣ GTP ⤖ྜ㡿ᇦࡼࡾ GTP ⤖ྜࡍࡿࡇ࡛᰾Ꮡᅾࡋࠊࢡࣛࢫ II せ⤌⧊㐺 ྜ㑇ఏᏊ(MHC 㑇ఏᏊ)ࢆṇไᚚࡋ࡚࠾ࡾࠊ ࠕ࣐ࢫ ࢱ࣮ไᚚᅉᏊࠖࡤࢀࡿࠋCIITA ࢱࣥࣃࢡ㉁ࡣ ᰾ᒁᅾࡍࡿࡀࠊDNA ⤖ྜࡏࡎᅛ᭷ࡢࢭࢳࣝ ࢺࣛࣥࢫࣇ࢙࣮ࣛࢮάᛶࡼࡾάᛶ⿵ຓᅉᏊ ࡋ࡚స⏝ࡍࡿࡀᰁⰍయୖ࠶ࡿ MHC 㡿ᇦࡣᩘ ⓒࡢ㑇ఏᏊࡀᏑᅾࡋࠊࡲࡓࠊ✀ࡼࡗ࡚ MHC 㡿 ᇦୖࡢ㑇ఏᏊࡣ␗࡞ࡗ࡚࠸ࡿࠋࡑࢀࡒࢀࡢ㑇ఏᏊ ࢆࢩ࣮ࣙࢺ࣊ࣆࣥ RNA ࢆⓎ⌧ࡍࡿࡇ࡛Ⓨ⌧ ᢚไࡋࠊࡑࡢᶵ⬟ࢆึࡵ࡚᫂ࡽࡋࡓ(Anim Sci J, 2015, Nagatomo et al., Jpn J Vet Res, 2015, Nagatomo et al.)ࠋຍ࠼࡚ࠊ࣑ࢺࢥࣥࢻࣜ࣊ࢸࣟࣉ ࣛࢫ࣑࣮࣐࢘ࢫ⬇ࡢసฟ᪉ἲࢆ᳨ウࡋࠊ⬇┙⬊ᮇ ࡲ࡛ࡢⓎ⏕⋡ࠊ࠾ࡼࡧࠊഇዷፎ࣐࢘ࢫ⛣᳜ᚋࡢ╔ ᗋ⬟࡞ࡽࡧⓎ⏕⬟ࢆ☜ࡵࡓࠋࡲࡓࠊಶࠎࡢ࣑ ࢺࢥࣥࢻࣜ DNA ࢥࣆ࣮ᩘࢆㄪࡿࡇ࡛࣊ࢸ ࣟࣉࣛࢫ࣑࣮ࡢᗘྜ࠸ࢆ᫂ࡽࡋࠊ࣑ࢺࢥࣥࢻ ࣜ-࣊ࢸࣟࣉࣛࢫ࣑࣮ࡀಶయⓎ⏕࠼ࡿᙳ㡪 ࡘ࠸࡚ㄪࡓࠋࡑࡢ⤖ᯝࠊ࣑ࢺࢥࣥࢻࣜ࣊ࢸ ࣟࣉࣛࢫ࣑࣮⬇ࡢ╔ᗋࡀ㜼ᐖࡉࢀࡿࡇࡀ ุ᫂ࡋࡓ(Sci Rep, 2015, Kawahara et al.)ࠋ ࡇࢀࡽࡢ◊✲ᡂᯝࡣࠊ࢘ࢩࡸ࣐࢘ࢫ࠸ࡗࡓ ࡃ␗࡞ࡿ✀࠾ࡅࡿึᮇ⬇Ⓨ⏕ࡢඹ㏻ᛶ┦㐪ࡢ ⌮ゎࢆ㐍ࡵࠊᚋࡢື≀Ⓨ⏕ᕤᏛ࠾ࡅࡿ့ங㢮 ⬇᧯సࡢ㌍㐍㈉⊩ࡍࡿࡶࡢᮇᚅࡉࢀࡿࠋ ㄽᩥⓎ⾲ 1. Requirement for nuclear autoantigenic sperm protein mRNA expression in bovine preimplantation development. Nagatomo H, Kohri N, Akizawa H, Hoshino Y, Yamauchi N, Kono T, Takahashi M, Kawahara M. Anim Sci J. 2015 Dec 22. doi: 10.1111/asj.12538. 2. Comparing spatial expression dynamics of bovine blastocyst under three different procedures: in-vivo, in-vitro derived, and somatic cell nuclear transfer embryos. Nagatomo H, Akizawa H, Sada A, Kishi Y, Yamanaka K, Takuma T, Sasaki K, Yamauchi N, Yanagawa Y, Nagano M, Kono T, Takahashi M, Kawahara M. Jpn J Vet Res. 2015 Nov;63(4):159-71. 3. Preimplantation death of xenomitochondrial mouse embryo harbouring bovine mitochondria. Kawahara M, Koyama S, Iimura S, Yamazaki W, Tanaka A, Kohri N, Sasaki K, Takahashi M. Sci Rep. 2015 Sep 29;5:14512. doi: 10.1038/srep14512. Ꮫ⾡Ⓨ⾲ 1. CIITA 㑇ఏᏊⓎ⌧ࡢᢚไࡀ࢘ࢩึᮇ⬇Ⓨ⏕ ࠼ࡿᙳ㡪㸬⛅ἑᏹ⣖㸪㛗ၨ᫂㸪ᐃ㑳㔛㸪 ᓊ㟹㸪ᒣ୰㈼୍㸪ルᦶဴஓ㸪బࠎᮌᜨு㸪 ᒣෆఙᙪ㸪ᰗᕝὒ㑻㸪Ọ㔝ᫀᚿ㸪Ἑ㔝ᏹ㸪 − 31 − MBS85 ࡢⓎ⌧ᢚไࡼࡿ⣽⬊ࡢຊࡢᙳ㡪ࢆ ホ౯ࡍࡿࡓࡵࠊḟࡢᡭἲࢆᑟධࡋࡓࠋࡲࡎࠊࣄ ࢺ⧄⥔ⱆ⣽⬊ᰴᑐࡋ࡚㸱ࡘࡢ᧯సࢆ⾜ࡗࡓࠋࡑ 2. ࢘ࢩ࠾ࡼࡧ࣐࢘ࢫࡢ࣑ࢺࢥࣥࢻࣜ࣊ࢸࣟࣉ ࢀࡒࢀࠊ ձShort interfering RNA ᑟධࡼࡿ MBS85 ࣛࢫ࣑࣮ࡀึᮇ⬇Ⓨ⏕ཬࡰࡍᙳ㡪㸬⏣୰ឡ ࡢ Knockdown (KD) Control(CO)ࠊղࢤࣀ࣒ࢆᨵ Ꮚ㸪㣤ᮧࡉࡳ㸪ᑠᒣリ⧊㸪ᒣᓮ΅㸪బࠎᮌ ኚࡋ࡚ MBS85 ࢆⓎ⌧࡛ࡁ࡞ࡃࡋࡓ Knockout (KO)ࠊ ᕝ ཎᏛ㸬᪥ᮏ␆⏘Ꮫ (Ụ ᜨு㸪㧗ᶫᫀᚿ㸪ᕝ ճ≉ู࡞᧯సࢆຍ࠼࡚࠸࡞࠸ Wild-type (WT)ࠊ࡛ ู)㸪2015 ᖺ㸬 ࠶ࡿࠋࡇࢀࡽࡢ⣽⬊⩌ࢆࢥ࣮ࣛࢤࣥࢤࣝ୰࡛ᇵ㣴 ࡋࠊ⣽⬊ࡢຊ࡛ࢤࣝࡢࡁࡉࡀ᭷ពኚࡍࡿ 3. Ⓨ࿘ᮇ࠾ࡅࡿ࢘ࢩ⏕Ṫჾࡢࢡ࣏ࣜࣥ㑇 ࠺ࢆィ ࡋࡓࠋ⣽⬊ࡢຊ౫Ꮡࡋࡓࢤࣝࡢኚ ఏᏊ⩌⌧ືែ㸬ᑠᮌ᭮㈗Ꮨ㸪ᒾ㔝ᘯᬦ㸪ⓑỈ ᙧࢆឤᗘⰋࡃ ᐃࡍࡿࡓࡵࠊࢤࣝࡢయ✚ࢥࣛ ㈗㸪ᕝ ᕝ ཎᏛ㸪㧗ᶫᫀᚿ㸬᪥ᮏ␆⏘Ꮫ (Ụ ࣮ࢤࣥࡢ⃰ᗘࠊ⣽⬊ࡢᩘࠊᇵ㣴᪥ᩘ࡞ࢆ᳨ウࡋ ู)㸪2015 ᖺ㸬 ࡓࠋ MBS85 ࡢⓎ⌧ᢚไࡣࠊ⣽⬊ࡢຊᙳ㡪ࢆ࠼ࡿ 4. Ⓨ࿘ᮇู࢘ࢩᏊᐑෆ⭷࠾ࡅࡿ TRP ࢳࣕࢿ ࡇࡀ᫂ࡽ࡞ࡗࡓࠋࡲࡎࠊMBS85 ≉␗ⓗ࡞ ࣝࡢⓎ⌧ືែ㸬ᒾ㔝ᘯᬦ㸪ᑠᮌ᭮㈗Ꮨ㸪ⓑỈ ᢠయࢆ⏝࠸࡚ࠊKD KO ࡢᡂຌࢆ☜ㄆࡋࡓࠋࡉࡽ ㈗㸪ᕝ ᕝཎᏛ㸪ᯞ㔜ᆂ♸㸪㧗ᶫᫀᚿ㸬᪥ᮏ␆ ࠊKO WT ⣽⬊ࡀᇙࡵ㎸ࡲࢀࡓࢤࣝࡢࡁࡉ ⏘Ꮫ (Ụู)㸪2015 ᖺ㸬 ࢆẚࡓࡇࢁࠊKO ⩌࡛ࡢ᭷ព࡞ῶᑡࡀ☜ㄆࡉࢀ ࡓࠋKD ⩌ࡢࢤࣝࡣ CO ⩌ẚ࡚᭷ពῶᑡࡍࡿ 5. ⪁༸Ꮚࡳࡽࢀࡿཷ⢭㞀ᐖ࠾ࡼࡧⓎ⏕㞀ᐖ ࡇࡀ᫂ࡽ࡞ࡗࡓࠋࡇࢀࡽࡢ⤖ᯝࡣࠊMBS85 ࡘ࠸࡚㸬 ᳝ྡᾈᕫ㸪㇂㢼ጲ㸪㧗ᶫᫀᚿ㸪 ࡢⓎ⌧㔞ࡢῶᑡࡀ⣽⬊ࡢຊࢆቑຍࡉࡏࡿࡇࢆ♧ ᕝཎᏛ㸬 ᾏ㐨␆⏘ⲡᆅᏛ (Ụู)㸪2015 ᖺ㸬 ၀ࡋ࡚࠸ࡿࠋࡇࡢ⤖ㄽࢆࡅࡿࡓࡵࠊKO ⣽⬊ MBS85 ࢆᙉไⓎ⌧ࡉࡏ(KO(OE))ࠊKO ⩌ࡢࢤ ࣝࡢࡁࡉࡢኚࢆẚࡓࠋࡑࡢ⤖ᯝࠊࢤࣝࡢ Ꮫ㝔ඛ➃⏕⛉Ꮫ◊✲㝔 ⦰ࡀ⦆ࡉࢀࡿࡇࡀ᫂ࡽ࡞ࡗࡓࠋࡇࢀࡣࠊ MBS85 ࡢⓎ⌧㔞ࢆᅇࡉࡏࡿࡇࡼࡾࠊቑࡋ ඛ➃⼥ྜ⛉Ꮫ◊✲㒊㛛 ࡚࠸ࡓ⣽⬊ࡢຊࡀᮏ᮶ࡢ್ᡠࡿഴྥࡀ࠶ࡿࡇ ⣽⬊ࢲࢼ࣑ࢡࢫ⛉Ꮫศ㔝 ࢆពࡍࡿࠋ௨ୖࡢ⤖ᯝࡽࠊMBS85 ࡢⓎ⌧ᢚไ ᕝ➃ 㔜࣭Ỉ㇂ Ṋ⮧ ࡣ⣽⬊ࡢຊࡢቑ⧅ࡀࡿࡇࡀ᫂ࡽ࡞ࡗࡓࠋ ⣽⬊ࡢຊࡀ㔜せ࡞ᙺࢆᯝࡓࡍ⮚ჾࡢ㑇ఏᏊ ᮏᖺᗘࡣࠊࢤࣀ࣒ࢲࢼ࣑ࢡࢫ◊✲ࢭࣥࢱ࣮ࢆ ⒪ࢆ⾜࠺ሙྜࡣࠊAAVS1 ࡣእ᮶㑇ఏᏊࡢᑟධඛ ⏝ࡍࡿࡇࡼࡾࠊࢤࣀ࣒⦅㞟క࠺⣽⬊ࡢຊ ࡋ ࡚ 㐺ࡋ࡚ ࠸ ࡞ ࠸ゝ ࠼ ࡿ (2015 T. Mizutani ࡢᙳ㡪ࡘ࠸࡚ࡢ◊✲ᡂᯝࡀᚓࡽࢀࡓࠋ BBRC)ࠋ ࣄࢺࢤࣀ࣒እ᮶㑇ఏᏊࢆᑟධࡍࡿࡇࡣࠊ㏆ AAVS1 ࡢࢤࣀ࣒⦅㞟ࡼࡗ࡚⣽⬊ࡢຊࡀኚ ࠸ᑗ᮶ࠊ㑇ఏᏊ⒪ἲࡢ୍ࡘࡋ࡚᭷⏝࡞ࡿࠋ ࡍࡿࡇࢆ♧ࡋ࡚ࡁࡓࡀࠊḟࠊ⣽⬊㐠ື⬟ࡢ እ᮶㑇ఏᏊࡢᑟධඛࡋ࡚ὀ┠ࡉࢀ࡚࠸ࡿࡢࡀࠊ ᙳ㡪ࢆㄪࡓࠋࢤࣀ࣒⦅㞟ࡼࡗ࡚ AAVS1 㑇ఏᏊ AAVS1 㑇ఏᏊᗙ࡛࠶ࡿࠋAAVS1 㑇ఏᏊᗙࡢእ᮶ ᗙ Green Fluorescent Protein 㑇ఏᏊࢆᑟධࡋࡓ⣽ 㑇ఏᏊࡢᑟධࡣࠊ ࠕእ᮶㑇ఏᏊࢆᣢ⥆ⓗⓎ⌧ྍ⬟ ⬊(KI)ࢆసᡂࡋࡓࠋKI ⣽⬊ࡲࡓࡣ WT ⣽⬊ࢆ࢞ࣛ ࡍࡿࠖ࠸࠺ᮏ᮶ࡢ┠ⓗຍ࠼࡚ࠊ ࠕ⣽⬊ࡢ⒴ ࢫᇶ┙ୖᇵ㣴ࡋࠊྛࠎࡢ⣽⬊ࡢ㐠ືࢆࢺࣛࢵ࢟ ࢆᘬࡁ㉳ࡇࡉ࡞࠸ࠖࠊࠕᖿ⣽⬊ࡢศ⬟ᙳ㡪ࢆ ࠼࡞࠸ࠖ ࠊ ࠕ⣽⬊ࡢ⾲⌧ᆺ᫂☜࡞ᙳ㡪ࢆ࠼࡞࠸ࠖ ࠊ ࣥࢢࡋࡓࠋKI ⩌ WT ⩌ࡢ㛫࡛⣽⬊ࡢ㐠ື᪉ྥᣢ ⥆ᛶࢆẚ㍑ࡋࡓࡇࢁࠊࡁ࡞ኚࡣぢࡽࢀ࡞ ࠸ࡗࡓᏳᛶࡢ㠃࠾࠸࡚ࡶ㐺ࡋ࡚࠸ࡿሗ࿌ ࡗࡓࠋ୍᪉ࠊ⣽⬊㐠ືࡢ㏿ࡉࢆẚࡓᡤࠊKI ⩌ࡼ ࡉࢀ࡚࠸ࡿࠋࡋࡋ࡞ࡀࡽࠊAAVS1 㑇ఏᏊᗙϩ ࡾࡶ WT ⩌ࡢ᪉ࡀ㏿ࡃ࡞ࡿഴྥ࠶ࡿࡇࡀศ ᆺ࣑࢜ࢩࣥ┦స⏝ࡍࡿࢱࣥࣃࢡ㉁㸦Myosin ࡗࡓࠋ௨ୖࡢ⤖ᯝࡽࠊAAVS1 ࡢࢤࣀ࣒⦅㞟ࡣ Binding Subunit 85; MBS85㸧ࡀࢥ࣮ࢻࡉࢀ࡚࠸ࡿࡓ ࡵࠊእ᮶㑇ఏᏊࡢᑟධࡼࡿ MBS85 ࡢⓎ⌧పୗࡀࠊ ⣽⬊㐠ືࡢ㏿ࡉࡶᙳ㡪ࡀ࠶ࡿࡇࡀ᫂ࡽ࡞ ࡗࡓࠋ ϩᆺ࣑࢜ࢩࣥࡢάᛶࡢኚࠊࡦ࠸࡚ࡣࠊ⣽⬊ࡢຊ ᙳ㡪ࢆ࠼ࡿྍ⬟ᛶࡀ࠶ࡿࠋᮏ◊✲ࡢ┠ⓗࡣࠊ (ㄽᩥⓎ⾲) AAVS1 㑇ఏᏊᗙࢥ࣮ࢻࡉࢀࡓ MBS85 ࡢⓎ⌧ᢚ Imai M., Furusawa K., Mizutani T., Kawabata K., ไࡀ⣽⬊ࡢຊᙳ㡪ࢆ࠼ࡿࡢ࠺ࢆ᫂ࡽ Haga H. (2015) Three-dimensional morphogenesis of ࡍࡿࡇ࡛࠶ࡿࠋ MDCK cells induced by cellular contractile forces on a 㧗ᶫᫀᚿ㸪ᕝཎᏛ㸬᪥ᮏ␆⏘Ꮫ (Ụู)㸪2015 ᖺ㸬 − 32 − viscous substrate. Scientific Reports 5: 14208. Ꮫ㝔ᕤᏛ◊✲㝔 Mizutani T., Li R., Haga H., Kawabata K. (2015) Transgene Integration into the Human AAVS1 Locus Enhances Myosin II-Dependent Contractile Force by Reducing Expression of Myosin Binding Subunit 85. Biochemical and Biophysical Research Communications 465(2): 270-274. Nukuda A., Sasaki C., Ishihara S., Mizutani T., Nakamura K., Ayabe T., Kawabata K., Haga H. (2015) Stiff Substrates Increase YAP-Signaling-Mediated Matrix Metalloproteinase-7 Expression. Oncogenesis 4: e165. Furusawa K., Mizutani T., Machino H., Yahata S., Fukui A., Sasaki N. (2015) Application of multichannel collagen gels in construction of epithelial lumen-like engineered tissues. ACS Biomaterials Science & Engineering 1(7): 539-548. Iguchi Y., Ishihara S., Uchida Y., Tajima K., Mizutani T., Kawabata K., Haga H. (2015) Filamin B enhances the invasiveness of cancer cells into 3D collagen matrices. Cell Structure and Function 40(2): 61-67. Takemoto K., Ishihara S., Mizutani T., Kawabata K., Haga H. (2015) Compressive stress induces dephosphorylation of the myosin regulatory light chain via RhoA phosphorylation by the adenylyl cyclase/protein kinase A signaling pathway. PLoS One 10(3): e0117937. Yanagawa F., Mizutani T., Sugiura S., Takagi T., Sumaru K., Kanamori T. (2015) Partially photodegradable hybrid hydrogels with elasticity tunable by light irradiation. Colloids Surf B Biointerfaces 126: 575-579. Yamaguchi N., Mizutani T., Kawabata K., Haga H. (2015) Leader cells regulate collective cell migration via Rac activation in the downstream signaling of integrin ȕ1 and PI3K. Scientific Reports 5: 7656. (ᏛⓎ⾲) Ỉ㇂ Ṋ⮧㸸ຊᏛィ ࡼࡿ⣽⬊㐠ືࡢࣉࣟ ࣮ࢳᛂ⏝ᒎ㛤㸬 ➨㸯㸵ᅇḟୡ௦་ᕤᏛ◊✲㸪 2015 ᖺ 7 ᭶ 30 ᪥㸪 Ⓩูࣉࣜࣥࢫ࣍ࢸࣝ▼Ỉீ㸦Ⓩูᕷ㸧 㸬 Takeomi Mizutani, Hisashi Haga, Kazushige Kawabata 㸸 Measurements and control of cellular mechanical factors during collective cell migration. ➨㸳㸱ᅇ᪥ᮏ⏕≀≀⌮Ꮫᖺ㸪2015 ᖺ 9 ᭶ 13 ᪥㸪㔠ἑᏛ㸦㔠ἑᕷ㸧 㸬 ᛂ⏝≀⌮Ꮫ㒊㛛 㔞Ꮚ≀ᛶᕤᏛศ㔝 ⏣ ⪽ 㸦⣧Ỉ⏝㸧 Ꮫ⾡ㄽᩥ Matsuura, T., Hara, J., Inagaki, K., Tsubota, M., Hosokawa, T., and Tanda, S. (2015) "Charge Density Wave Soliton Liquid", EPL 109: 27005-p1-p6. Hosokawa, T., Matsuura, K., Tsubota, M., and Tanda, S. (2015) "Single-Valuedness Problem on Charge Density Wave Rings", EPL 112: 27005-p1-p5. Kawashima, Y., Ichimura, K., Katono, K., Kurosawa, T., Oda, M., Yamaya, K., Tanda, S., Kamihara, Y., and Hosono, H. (2015) "STM/STS Study of the Superconducting Gap in SmFeAsO1-xFx", Solid State Communications 204: 33-36. Katono, K., Taniguchi, T., Ichimura, K., Kawashima, Y., Tanda, S., and Yamamoto, K. (2015) "STM Observation of Charge Stripe in Metallic Phase of D-(BEDT-TTF)2I3", Physical Review B 91: 125110-1-5. Oka, Y., Nobukane, H., Matsunaga, N., Nomura, K., Katono, Ichimura, K., and Kawamoto, A. (2015) "Tunneling Spectroscopy in Organic Superconductor N-(BEDT-TTF-d[3,3])2Cu[N(CN)2]Br", Journal of the Physical Society of Japan 84: 064713-1-6. Matsuura, T., Hara, J., Inagaki, K., Tsubota, M., Hosokawa, T., and Tanda, S. (2015) "Melted Discommensuration of Charge Density Waves", Pysica B 460: 30-33. Katono, K., Ichimura, Taniguchi, T., K., Kawashima, Y., Yamaya, K., and Tanda, S. (2015) "Charge Disproportionationin D-(BEDT-TTF)2X", Pysica B 460: 64-67. Oka, Y., Nobukane, H., Matsunaga, N., Nomura, K., Katono, Ichimura, K., and Kawamoto, A. (2015) "STM Spectroscopy on Deuterated N-(ET-d[3,3])2Cu[N(CN)2]Br", Pysica B 460: 93-95. Kanno, T., Matsumoto, T., Ichimura, K., Matsuura, T., and Tanda, S. (2015) "Metal-Insulator Transition in Iron Doped 2H-TaSe2: Suggestion of Chiral Unitary Localization", Pysica B 460: 165-167. Hosokawa, T., Matsuura, K., Tsubota, M., and Tanda, S. (2015) "Hysteretic Current Switching Phenomena in TaS3 Ring Crystals", Pysica B 460: 171-173. − 33 − ᏛⓎ⾲ ⏣⪽㸪㓇㒊ᶞ㸪ᯇᾆᚭ㸪ᮎỌ▱㸪ᓠ㸸MX2 ࣔࣀ࣮ࣞࣖࡢ≀⌮⌧㇟㸬᪥ᮏ≀⌮Ꮫ➨ 70 ᅇᖺ ḟ㸪2015 ᖺ 3 ᭶ 21-24 ᪥㸪᪩✄⏣Ꮫ᪩✄⏣ ࢟ࣕࣥࣃࢫ㸦ᮾி㒔᪂ᐟ༊㸧㸬 ⏣⪽㸪㓇㒊ᶞ㸪ᯇᾆᚭ㸪ᮎỌ▱㸪ᓠ㸸1T-TaS2 ࡢ 1, 2, 3 ᒙ࣮ࣞࣖࡢ≀⌮⌧㇟㸬᪥ᮏ≀⌮Ꮫ➨ 70 ᅇᖺḟ㸪2015 ᖺ 3 ᭶ 21-24 ᪥㸪᪩✄⏣Ꮫ ᪩✄⏣࢟ࣕࣥࣃࢫ㸦ᮾி㒔᪂ᐟ༊㸧 㸬 ᯇᾆᚭ㸪ཎ῟㸪✄ᇉඞᙪ㸪ᆤ⏣㞞ຌ㸪⣽ᕝ㸪 ⏣⪽㸸㟁ⲴᐦᗘἼ࠾ࡅࡿࢯࣜࢺࣥᾮయ≧ែ㸬᪥ ᮏ≀⌮Ꮫ➨ 70 ᅇᖺḟ㸪2015 ᖺ 3 ᭶ 21-24 ᪥㸪 ᪩✄⏣Ꮫ᪩✄⏣࢟ࣕࣥࣃࢫ㸦ᮾி㒔᪂ᐟ༊㸧 㸬 ✄ᇉඞᙪ㸪ᯇᾆᚭ㸪ᆤ⏣㞞ຌ㸪Ᏹ㐍ஓ㸪ᮏ㛫㱟 ஓ㸪⏣⪽㸸ᨃ୍ḟඖᑟయ o-TaS3 ࠾ࡅࡿ␗᪉ⓗ ☢Ẽᢠ㸬᪥ᮏ≀⌮Ꮫ➨ 70 ᅇᖺḟ㸪2015 ᖺ 3 ᭶ 21-24 ᪥㸪᪩✄⏣Ꮫ᪩✄⏣࢟ࣕࣥࣃࢫ㸦ᮾ ி㒔᪂ᐟ༊㸧 㸬 ୰ὠᕝၨ㸪ᯇᾆᚭ㸪⸨ᩄஅ㸪⏣⪽㸸Quantum Space-Time Crystal in Charge Density Wave Rings㸬᪥ ᮏ≀⌮Ꮫ➨ 70 ᅇᖺḟ㸪2015 ᖺ 3 ᭶ 21-24 ᪥㸪 ᪩✄⏣Ꮫ᪩✄⏣࢟ࣕࣥࣃࢫ㸦ᮾி㒔᪂ᐟ༊㸧 㸬 ࢚ࢿࣝࢠ࣮⎔ቃࢩࢫࢸ࣒㒊㛛 ᛂ⏝࢚ࢿࣝࢠ࣮ࢩࢫࢸ࣒ศ㔝 ㏆ஂ Ṋ⨾ 㸦⣧Ỉ⏝㸧 Ⓨ⾲ㄽᩥ Tabe, Y., Aoyama, Y., Kadowaki, K., Suzuki, K., and Chikahisa, T. (2015) Impact of micro-porous layer on liquid water distribution at the catalyst layer interface and cell performance in a polymer electrolyte membrane fuel cell. Journal of Power Sources 287: 422-430. Aoyama, Y., Suzuki, K., Tabe, Y., Chikahisa, T., and Tanuma, T. (2016) Water Transport and PEFC Performance with Different Interface Structure between Micro-Porous Layer and Catalyst Layer. Journal of The Electrochemical Society 163 (5): F359-F366. Aoyama, Y., Suzuki, K., Tabe, Y., Chikahisa, T., and Tanuma, T. (2015) Effect of Hydrophilic Micro-porous Layer Structure on Microscopic Water Distribution and Cell Performance in PEFC. ECS Transactions 69 (17): 743-752. Tabe, Y., Akabori, S., Hayashi, T., Suzuki, K., Chikahisa, T. (2015) Analysis of Cathode Catalyst Layer Structure and Oxygen Transport Resistance Depending on Fabrication Condition in PEFC. ECS Transactions 69 (17): 773-781. ᏛⓎ⾲ ㉥ᇼ΅㸪㕥ᮌ◊ᝅ㸪⏣㒊㇏㸪㏆ஂṊ⨾㸸ᅛయ㧗ศ Ꮚᙧ⇞ᩱ㟁ụ࠾ࡅࡿゐ፹ᒙస〇᮲௳ࡼ ࡿせᵓ㐀ኚ࠾ࡼࡧ㟁ụᛶ⬟ゎᯒ㸬➨ 52 ᅇ᪥ᮏఏ⇕ࢩ࣏ࣥࢪ࣒࢘㸪2015 ᖺ 6 ᭶ 3 ᪥㸪 ⚟ᒸᅜ㝿㆟ሙ㸦⚟ᒸᕷ㸧 㸬 㟷ᒣ♸㸪㕥ᮌ◊ᝅ㸪⏣㒊㇏㸪㏆ஂṊ⨾㸪⏣ᩄ㸸 ぶỈᛶ MPL ࢆ᭷ࡍࡿᅛయ㧗ศᏊᙧ⇞ᩱ㟁 ụࡢⓎ࠾ࡼࡧ⏕ᡂỈศᕸ≉ᛶ㸬➨ 52 ᅇ᪥ᮏ ఏ⇕ࢩ࣏ࣥࢪ࣒࢘㸪2015 ᖺ 6 ᭶ 3 ᪥㸪⚟ᒸ ᅜ㝿㆟ሙ㸦⚟ᒸᕷ㸧 㸬 ෆᒣ┿⌮㸪ᔱ⏣㑈㸪㕥ᮌ◊ᝅ㸪⏣㒊㇏㸪㏆ஂṊ⨾㸸 ࣞࢻࢵࢡࢫࣇ࣮ࣟ㟁ụࡢά≀㉁㍺㏦ࡀ㟁ὶ ᐦᗘศᕸཬࡰࡍᙳ㡪ゎᯒ㸬➨ 52 ᅇ᪥ᮏఏ ⇕ࢩ࣏ࣥࢪ࣒࢘㸪2015 ᖺ 6 ᭶ 4 ᪥㸪⚟ᒸᅜ 㝿㆟ሙ㸦⚟ᒸᕷ㸧 㸬 ᔱ⏣㑈㸪ෆᒣ┿⌮㸪㕥ᮌ◊ᝅ㸪⏣㒊㇏㸪㏆ஂṊ⨾㸸 ࣞࢻࢵࢡࢫࣇ࣮ࣟࣂࢵࢸ࣮ࣜࡢᨺ㟁ຠ⋡ ཬࡰࡍ㟁ゎᾮὶື᮲௳ࡢᙳ㡪ゎᯒ㸬➨ 20 ᅇືຊ࣭࢚ࢿࣝࢠ࣮ᢏ⾡ࢩ࣏ࣥࢪ࣒࢘㸪2015 ᖺ 6 ᭶ 18 ᪥㸪ᮾᏛ㸦ྎᕷ㸧 㸬 ▼㛫⿱ኴ㸪㕥ᮌ◊ᝅ㸪⏣㒊㇏㸪㏆ஂṊ⨾㸸㐣෭༷ ࢆక࠺ PEFC ịⅬୗ㉳ືࡢịᙧᡂᣲື㸬 ➨ 20 ᅇືຊ࣭࢚ࢿࣝࢠ࣮ᢏ⾡ࢩ࣏ࣥࢪ࣒࢘㸪 2015 ᖺ 6 ᭶ 18 ᪥㸪ᮾᏛ㸦ྎᕷ㸧 㸬 すᕝᾈ⮳㸪㕥ᮌ◊ᝅ㸪⏣㒊㇏㸪㏆ஂṊ⨾㸸PEFC ị Ⅼୗ㉳ື≉ᛶཬࡰࡍ࢝ࢯ࣮ࢻゐ፹ᒙෆ࢝ ࣮࣎ࣥࣈࣜࢵࢪᵓ㐀ࡢᙳ㡪㸬➨ 47 ᅇᏛᕤ Ꮫ⛅Ꮨ㸪2015 ᖺ 9 ᭶ 10 ᪥㸪ᾏ㐨 Ꮫ㸦ᮐᖠᕷ㸧 㸬 ඵ㔜ཎᖿᶞ㸪㕥ᮌ◊ᝅ㸪⏣㒊㇏㸪㏆ஂṊ⨾㸸ⓎἻ 㔠ᒓὶ㊰ᆺ PEFC ࡢᛶ⬟࠾ࡼࡧỈ㍺㏦⌧㇟ ཬࡰࡍ✵㝽ᵓ㐀ᙳ㡪㸬᪥ᮏᶵᲔᏛ 2015 ᖺᗘᖺḟ㸪2015 ᖺ 9 ᭶ 15 ᪥㸪ᾏ㐨 Ꮫ㸦ᮐᖠᕷ㸧 㸬 ప ⛉Ꮫ◊✲ᡤ ⏕≀⎔ቃ㒊㛛 ⏕≀㐺ᛂศ㔝 ఀ⸨ ᑑ 㸦ᾏỈ⏝㸧 ㄽᩥⓎ⾲ Sato, R., Ito, H. and Tanaka, A. (2015) Chlorophyll b degradation by chlorophyll b reductase under high-light conditions. Photosynthesis Research 126: 249-259. − 34 − ᏛⓎ⾲ ᯇ⏣㤶⧊ࠊୗ⏣ὒ㍜ࠊఀ⸨ᑑࠊ⏣୰Ṍ㸸ࢡ࣑ࣛࢻ ࣔࢼࢫࡢࢡࣟࣟࣇࣝศゎ㓝⣲ SGR ࡢᶵ⬟ゎᯒ ➨ 57 ᅇ᪥ᮏ᳜≀⏕⌮Ꮫ 2016 ᖺ 3 ᭶ 18 ᪥ ᒾ ᡭᏛ㸦┒ᒸᕷ㸧 㟁Ꮚ⛉Ꮫ◊✲ᡤ ⏕⛉Ꮫ◊✲㒊㛛 」㞧⣔ᩘ⌮◊✲ศ㔝 㟷 ோᚿ ᡃࠎࢆྲྀࡾᕳࡃ⎔ቃࡣ୍้้ኚࡋண ྍ ⬟࡛࠶ࡿ㸬ࡇࡢࡼ࠺࡞↓㝈ᐃ⎔ቃࡢ୰࡛ື≀ࡣ㐺 ᛂⓗ㐠ືࡸ⾜ືࢆࡍࡿࡇࡀ࡛ࡁࡿ㸬୍᪉㸪᪤ Ꮡࡢேᕤ≀㸦ࣟ࣎ࢵࢺ㸧ື≀ࡢࡼ࠺࡞㐺ᛂⓗ࡞ ືసࢆࡉࡏࡿࡇࡣ⮳㞴ࡢᢏ࡛࠶ࡿ㸬࠼ࡤ㸪⏘ ᴗ⏝ࣟ࣎ࢵࢺࡣ㎿㏿࡛ࡋ࡞ࡸ࡞ືసࢆࡉࡏࡿ ࡇࡣ࡛ࡁࡿࡀ㸪㝈ࡽࢀࡓ⎔ቃୗ࡛㝈ࡽࢀࡓືస ࢆࡉࡏ࡚࠸ࡿࡽ࡛࠶ࡾ㸪୍᪦↓㝈ᐃ࡞⎔ቃୗ ᣢࡕฟࡏࡤືࡍࡇࡍࡽ༴࠺ࡃ࡞ࡗ࡚ࡋࡲ࠺㸬 ࣟ࣎ࢵࢺࡣ㸪࿘ࡾࡢ⎔ቃࢆほ ࡋ㸪ほ ⤖ᯝᛂ ࡌ࡚ືసฟຊࢆỴࡵ࡚࠸ࡿࡓࡵ࡛㸪ィ 㝈⏺ࢆ㉸ ࠼ࡓ⎔ቃୗ࡛ࡣືస࡛ࡁ࡞࠸ࡽ࡛࠶ࡿ㸬᪤▱ࡢ ⎔ቃࡢ୰࡛ࡋேᕤ≀ࢆไᚚࡍࡿ᪉ἲࡋᣢࡕྜ ࢃࡏ࡚࠸࡞࠸ᡃࠎࡗ࡚ࡇࡢࡼ࠺࡞ࣇ࣮࣒ࣞၥ 㢟ᑐฎࡍࡿࡣఱࡽࡢᡭᮏࡀᚲせ࡛࠶ࡾ㸪ࡑ ࢀࡀ⏕≀࡛࠶ࡿ㸬ື≀ࡣ㸪ࣇ࣮࣒ࣞၥ㢟ᤊࢃࢀ ࡿࡇ࡞ࡃ㸪⎔ቃࡢኚࡸ≧ἣᛂࡌ࡚㐺ᛂⓗ࡞ 㐠ືࡸ⾜ືⓎ⌧ࢆᐇ㛫࡛ᐇ⌧ࡋ࡚࠸ࡿ㸬ᡃࠎࡣ㸪 ࡇࡢᵝ࡞㐺ᛂⓗ࡞㐠ືࡸ⾜ືࡢᇶ┙࡞ࡿ㌟యࡸ ⬻ࡢ࣓࢝ࢽࢬ࣒ࢆ⌮ゎࡋ㸪᭦ࡑࡇࡽ᪂ወ࡞ே ᕤ≀ࡢไᚚㄽࡢ☜❧ࢆ┠ᣦࡋ࡚࠸ࡿ㸬ࡑࡢࡓࡵ㸪 ಶయࢆྲྀࡾᕳࡃ⎔ቃࡸಶయࡢ㌟యࡢືసࢆ᧯సࡍ ࡿࡇ࡛㐺ᛂⓗ࡞㐠ືࡸ⾜ືࡢᇶ┙࡞ࡿไᚚᶵ ᵓࢆ࠶ࡪࡾฟࡋ⌮ゎࡋࡼ࠺ࡋ࡚࠸ࡿ㸬᪻ࡢࢡ ࣟࢥ࢜ࣟࢠ(Gryllus bimaculatus)ࡸࢡ࣐ࣟࣖࣜ (Formica japonica)➼ࢆࡗࡓ◊✲࡛ࡣ㸪⪅ࡀᏑ ᅾࡍࡿ♫ࢆ⎔ቃせᅉࡢࡦࡘᤊ࠼㸪ಶయ㛫ࡢ ┦స⏝ࡼࡗ࡚ෆ㒊≧ែࡀኚᐜࡋ㸪㐺ᛂⓗ࡞⾜ ືࡀⓎ⌧ࡍࡿ࣓࢝ࢽࢬ࣒ࢆㄪࡓ㸬ࢭ࢝ࢦࢣࢢ ࣔ(Latrodectus hasseltii)࡛ࡣ㸪ᵓ⠏ࡋࡓᕢࡢᙧ≧ ᨷᧁᛶࡘ࠸࡚ㄪࡓ㸬ࢡࣔࣄࢺࢹ(Ophiarachna incrassate) ࡸࢭࢫࢪ࣒࢝࢝ࢹ(Scolopocryptops rubiginosus)㸪㌟యࡢ㐠ືᶵ⬟ࢆேⅭⓗᣊ᮰ࡋ㸪 ࡑࡢࡢࣟࢥ࣮ࣔࢩࣙࣥᵝᘧࡢኚࢆほᐹࡍࡿࡇ ࡛㸪ࡲࡓࢮࣀࣃࢫ(Xenopus laevis)࡛ࡣ㸪ฟࡋࡓ ⭌⭡➽3Dࣉࣜࣥࢱ࡛సࡗࡓ㦵᱁ࢆࡗࡓࣥࢻ ࣟࢻࢆ᧯సࡍࡿࡇ࡛㸪⎔ቃ㌟యࡢ┦స⏝ ࡽ⏕ࡌࡿ㐺ᛂᶵ⬟ࡢ࣓࢝ࢽࢬ࣒ࡘ࠸࡚⪃ᐹࡋ ࡓ㸬ࡇࢀࡽᵝࠎ࡞ᐇ㦂ື≀ࢆ⏝࠸ࡓ◊✲ࡽ㸪㐺 ᛂⓗ࡞㐠ືࡸ⾜ືࡢⓎ⌧ࡣ㸪ᵝࠎ࡞㝵ᒙ࠾ࡅ ࡿከ㔜ࣇ࣮ࢻࣂࢵࢡᵓ㐀ࡀ㔜せ࡞㘽࡞ࡿࡇ ࡀࢃࡗࡓ㸬 ㄽᩥⓎ⾲ Ohkawara, K. and Aonuma H. (2016) Changes in the levels of biogenic amines associated with aggressive behavior of queen in the social parasite ant Vollenhovia nipponica. Insectes Sociaux. doi:10.1007/s00040-016-0461-7. (Published online first) Newland P.L., al Ghamdi M., Sharkh S., Aonuma H. and Jackson C.W. (2015) Exposure to static electric fields leads to changes in biogenic amine levels in the brains of Drosophila. Proc. Roy. Soc. B., doi: 10.1098/rspb.2015.1198. 㧗ᶫᝅ㸪ዟ⏣Ὀ㸪ᕝ➃㑥᫂㸪㟷ோᚿ㸪బ⸨㞝 㝯㸪ᒾ⏣ྖ (2015 Accepted) ࢡࣟࢥ࢜ࣟࢠࡢ ⾜ືゎᯒྥࡅࡓື⏬ീィ ᡭἲ (ⱥㄒ⾲㢟㸸 Method of dynamic image measurement for analyzing of cricket behavior). J. Signal Processingࠕಙྕฎ⌮ࠖ. ᑠᯘ㸪∦ᒸᓫ㸪㟷ோᚿ㸪ᰘ⏣ὒ୍ (2015) ࣚࢺ ࢘࢞ࡢᛶࣇ࢙ࣟࣔࣥᑐࡍࡿゐゅ㟁ᛂ⟅. (ⱥ ㄒ⾲㢟㸸Response of the bioelectric potential within antenna of Mamestra Brassicae against sex pheromone). ㎰ᴗ㣗ᩱᕤᏛㄅ㸪77(3): 179-185. ⴭ᭩ Aonuma H. (2015 in press) Fighting behaviorUnderstanding the mechanisms of group size dependent aggression. in Cricket as a model organism for the 21st century; Development, Regeneration, and Behavior. (Eds: Noji S., Horch H.W., Ohuchi H. and Mito T.) Springer. Aonuma H. (2015 in press) Behavior- Synthetic approaches for observing and measuring cricket behaviors. in Cricket as a model organism for the 21st century; Development, Regeneration, and Behavior. (Eds: Noji S., Horch H.W., Ohuchi H. and Mito T.) Springer. Sakai R., Shimizu M., Aonuma H. and Hosoda K. (2015) Visualizing wakes in swimming locomotion of Xenopus-Noid by using PIV. in Biomimetic and Biohybrid Systems. (Eds: Wilson S.P., Verschure P. F.M.J., Mura A. and Prescott T.J.) Springer pp. 97-100. Aonuma H., Sakura M. and Kurabayasi D. (2015) Memory mediated by internal state: memory of lost suppresses motivation of fight in the cricket. in Memory Consolidation. (Eds: Sakakibara M. and Ito E) Nova Science Publisher. pp38-52. − 35 − ᏛⓎ⾲ Matsuzaka Y., Sato E., Kano T., Aonuma H. and Ishiguro A.: “Distributed yet functionally divided nervous system of ophiuroids: evidence from local nerve block experiments”, ➨93ᅇ᪥ᮏ⏕⌮Ꮫ, ᪫ᕝ་⛉Ꮫ (2016-03) 㟷 ோᚿ: ࠕ᪻ࡢ♫⾜ືࡳࡽࢀࡿ⮬ᕫ ⪅ࡢ㠀ศ㞳ᛶࠖࠊィ ⮬ືไᚚᏛ ➨28ᅇ⮬ ᚊศᩓࢩ࣏ࣥࢪ࣒࢘ OS:ࢥࢺࣟࢪ࣮ᡂࠊᗈᓥ Ꮫ (2016-01) Kimura F., Aonuma H., Sato T. and Sakura M.: “Change in biogenic amine levels in the narrow-winged mantis Tenodera angustipennis caused by the parasitic horsehair worm Chordodes sp.”, ➨40ᅇ᪥ᮏẚ㍑ෆศἪᏛ࣭➨37ᅇ᪥ᮏẚ ㍑⏕⌮⏕Ꮫ ྜྠ㸦CompBiol 2015ᗈᓥ 㸧, ᗈᓥᕷJMSࢫࢸ࣮ࣝࣉࣛࢨ (2015-12) Okada R., Ikeno H., Kimura T., Ohashi M., Aonuma H. and Ito E.: “Behavioral pattern of a follower bee during the honeybee dance communication”, ➨40 ᅇ᪥ᮏẚ㍑ෆศἪᏛ࣭➨37ᅇ᪥ᮏẚ㍑⏕⌮⏕ Ꮫ ྜྠ㸦CompBiol 2015ᗈᓥ㸧, ᗈ ᓥᕷJMSࢫࢸ࣮ࣝࣉࣛࢨ (2015-12) Matsuo R., Tanaka M., Fukata R., Kobayashi S., Aonuma H. and Matsuo Y.: “Octopaminergic system in the brain of the terrestrial slug Limax”, ➨40ᅇ᪥ᮏẚ㍑ෆศἪᏛ࣭➨37ᅇ᪥ᮏẚ㍑⏕ ⌮⏕Ꮫ ྜྠ㸦CompBiol 2015ᗈᓥ㸧, ᗈᓥᕷJMSࢫࢸ࣮ࣝࣉࣛࢨ (2015-12) Ώ㑔 ᓫஅࠊᏱ㈡⚄ ⠜ࠊ㟷 ோᚿ: ࠕཎጞⓗ࡞ ᪻⬻࡛Ⓨ⌧ࡍࡿ᭱ึᮇ㑇ఏᏊࡢ᥈⣴ࠖࠊ ᪥ᮏື≀Ꮫ ➨86ᅇࠊ᪂₲ࢥࣥ࣋ࣥࢩࣙ ࣥࢭࣥࢱ࣮ ᮒ㮛࣓ࢵࢭ (2015-09) Ono T., Kano T., Aonuma H. and Ishiguro A.: “Intra-limb Coordination Mechanism of Ophiuroid Locomotion”, Joint meeting of the 5th China-Japan-Korea Colloquium on Mathematical Biology and the 25th Annual Meeting of the Japanese Society for Mathematical Biology, ྠᚿ ♫Ꮫฟᕝ࢟ࣕࣥࣃࢫ (2015-08) Watanabe T., Atsushi U. and Aonuma H.: “Neurogeneitcs in the field cricket Gryllus bimaculatus – a novel experimental approach to understand neural/molecular bases of instinctive behaviors of basal insects”, 13th ISIN Symposium on the Neurobiology of Invertebrates, Tihany, Hungary (2015-08) Watanabe T. and Aonuma H.: “Sex-determination genes in the cricket brain - identification, expression and molecular evolution”, 13th ISIN Symposium on the Neurobiology of Invertebrates, Tihany, Hungary (2015-08) Ώ㑔 ᓫஅࠊ㟷 ோᚿ : ࠕኚែ᪻⬻࡛Ⓨ ⌧ࡍࡿᛶỴᐃᅉᏊࡢゎᯒࠖࠊ᪥ᮏ㐍Ꮫ➨17 ᅇᮾிࠊ୰ኸᏛᚋᴦᅬ࢟ࣕࣥࣃࢫ (2015-08) Sakai R., Shimizu M., Aonuma H. and Hosoda K.: “Visualizing wakes in swimming locomotion of Xenopus-noid by using PIV”, The 4th International Conference on Biomimetic and Biohybrid Systems, Living Machines 2015, La Pedrera Barcelona, Spain (2015-07) Aonuma H., Goda M., Kuroda S., Kano T., Owaki D. and Ishiguro A.: “Cricket switches locomotion patterns from walking to swimming by evaluating reaction forces from the environment”, The 7th International Symposium on Adaptive Motion of Animals and Machines (AMAM2015), MIT, USA (2015-06) ᑠ㔝 㐩ஓࠊຍ⣡ ๛ྐࠊ㟷 ோᚿࠊᯇᆏ ⩏ဢࠊ ▼㯮 ❶ኵ : ࠕ⎔ቃࡽࡢᡭᛂ࠼ࢆά⏝ࡍࡿࢡ ࣔࣄࢺࢹࡢࣟࢥ࣮ࣔࢩࣙࣥෆᅾࡍࡿ⮬ᚊศ ᩓไᚚ๎ࠖࠊࣟ࣎ࢸࢡࢫ࣭࣓࢝ࢺࣟࢽࢡࢫㅮ ₇ࠊி㒔ᕷ່ᴗ㤋ࠕࡳࡸࡇࡵࡗࡏࠖ (2015-05) ᯇᆏ ⩏ဢࠊబ⸨ ⱥẎࠊຍ⣡ ๛ྐࠊᆏᮏ ⩏ဢࠊ 㟷 ோᚿࠊ▼㯮 ❶ኵ : ࠕᒁᡤ㯞㓉ᐇ㦂ࡽ᥈ ࡿࢡࣔࣄࢺࢹࡢṌ⾜ไᚚࡢ⚄⤒ᶵᵓࠖࠊ᪥ᮏ⏕ ⌮Ꮫ ➨45ᅇᮾ⏕⌮ㄯヰࠊᮾᏛ∦ᖹ ࢟ࣕࣥࣃࢫ (2013-10) 㟷 ோᚿ: ࠕ᪻ࡢಶయ㛫┦స⏝ࡼࡿᨷᧁᛶ ࡢኚᐜ࣓࢝ࢽࢬ࣒ࡢ⌮ゎࠖࠊィ ⮬ືไᚚᏛ ࣭ศᏊࣟ࣎ࢸࢡࢫ◊✲ᐃࠕศᏊࣟ࣎ ࢵࢺࡢ▱⬟ࠥࣟࢪ࢝ࣝ࡞ࢩࢫࢸ࣒ࢆ࠸ᵓ ⠏ࡍࡿࠥࠖࠊᾏ㐨Ꮫ⌮Ꮫ㒊㸵ྕ㤋 (2015-05) 㟷 ோᚿࠊᯘ ㍜ࠊᕝ➃ 㑥᫂ࠊబ ⥳ : ࠕࢢ ࣮ࣝࣉࢧࢬᛂࡌࡓࢥ࢜ࣟࢠࡢᨷᧁ⾜ືࡢ ືᶵࡅ࣓࢝ࢽࢬ࣒ࠖࠊ㝃⨨◊✲ᡤ㛫ࣛ ࣥࢫࡼࡿࢼࣀ࣐ࢡࣟࢆࡘ࡞ࡄ ≀㉁࣭ࢹࣂ ࢫ࣭ࢩࢫࢸ࣒〇ᡓ␎ࣉࣟࢪ࢙ࢡࢺ H26 ᖺ ᗘࣛࣥࢫᡂᯝሗ࿌ࠊᕞᏛ ఀ㒔࢟ ࣕࣥࣃࢫ࣮࢝࣎ࣥࢽ࣮ࣗࢺ࣭࢚ࣛࣝࢿࣝࢠ࣮ᅜ 㝿◊✲ᡤ (2015-04) ᪉⏕≀ᅪࣇ࣮ࣝࢻ⛉Ꮫࢭࣥࢱ࣮ ⏕≀ከᵝᛶ㡿ᇦ ᾏ⏘⸴㢮㐺ᛂᶵ⬟ศ㔝 ᅄࢶ 㸦ᾏỈ⏝㸧 㸦ㄽᩥ㸧 ࣭⛅㔝⚽ᶞ, ᕝ၏ྐ, ᅄࢶ, Ἑ㔝ᘅ. (2015) ᾏ㐨Ἡᮧἢᓊ⾲ᒙ࠾ࡅࡿ࣍ࢯ࣓ࢥࣥࣈ 㐟㉮Ꮚࡢ⛣㏦✵㛫ⓗศᕸ. Ỉ⏘ᕤᏛ 52: 1-9. − 36 − ࣭ Miyashita, T., Kunitake, H., Yotsukura, N., and Hoshino, Y. (2015) Assessment of genetic relationships among cultivated and wild Rubusaccessions using AFLP markers. Scientia Horticulturae 193: 165–173. ࣭Kawai, T., Nagai, N., Klochkoba, N.G., and Yotsukura, N. (2015) Potential resource of Saccharina bongardiana for kelp fisheries in South Kamchatka, Far East Russia, Algal Resources 8: 59-64. ࣭ Kawai, T., Galanin, D., Krupnova, T.N., and Yotsukura, N. (2015) Catch and cultivation of Saccharina japonica in Northern Hokkaido, Japan, and southern Sakhalin and Primorye, Russia: A review, Algal Resources 8: 155-163. ࣭Yotsukura, N., Maeda, T., Abe, T., Nakaoka, M., and Kawai, T. (2016) Genetic differences among varieties of Saccharina japonica in northern Japan as determined by AFLP and SSR analyses, Journal of Applied Phycology Online First. 㸦ᏛⓎ⾲㸧 ࣭Kawai, T., Klimova, A.V., Nagai, N., Klochkova, N.G., and Yotsukura, N.㸸Fisheries Biology of Saccharina bongardiana, South Kamchatka, Far-east Russia. ᪥ᮏ ᛂ⏝⸴㢮Ꮫ➨ 14 ᅇ, 2015 ᖺ 5 ᭶ 16 ᪥, ᮾி ᾏὒᏛ㸦ᮾி㒔 ༊㸧. ࣭Ώ㎶ኴ㑻, ᅄࢶ, ᒣ๛ஂ, ௰ᒸ㞞⿱㸸 ࢥࣥࣈ┠㔜せᾏᇦࡢ㑅ᐃ㸫ࡑࡢከᵝᛶ࣭ᑗ᮶ศᕸ ண ࢆࡶ㸫. ᪥ᮏ⏕ែᏛ➨ 63 ᅇྎ , 2016 ᖺ 3 ᭶ 26 ᪥, ྎᅜ㝿ࢭࣥࢱ࣮㸦ྎᕷ㸧. ࣭ᏳỌ᫂, ⛅㔝⚽ᶞ, ⛙ Ᏻྐ, ྜྷ⏣⚽Ⴙ, ୰ከ ❶ᩥ, ୕ཎ⾜㞝, ᓮṇ, ᅄࢶ㸸ᾏ㐨す ᪥ᮏᾏἢᓊ࡛ᣢ⥆ⓗᙧᡂࡉࢀࡿ࣍ࢯ࣓ࢥࣥࣈ⸴ ሙࡢᾏὒ⎔ቃࡘ࠸࡚. ᖹᡂ 28 ᖺᗘ᪥ᮏỈ⏘Ꮫ Ꮨ, 2016 ᖺ 3 ᭶ 29 ᪥, ᮾிᾏὒᏛ㸦ᮾி 㒔 ༊㸧. ⥲ྜ༤≀㤋 ◊✲㒊 ㈨ᩱᇶ♏◊✲⣔ 㧗ᶫ ⱥᶞ ᮏᖺᗘࡣࠊᮏᖺᗘ࠾ࡼࡧ㐣ᖺᗘࡢ◊✲ࢹ࣮ࢱࢆ ⏝࠸࡚ࠊᮏᕞ୰㒊ࡽᾏ㐨ࡢ᪥ᮏᾏഃศᕸࡋࠊ ᪥ᮏᅛ᭷✀ࡉࢀࡿ࢜ࢽࣀ࢞ࣜࣖࢫ C. gigas ࡢ✀ ෆศ㢮⩌ࢆ᳨ウࡋࡓࠋ࢜ࢽࣀ࢞ࣜࣖࢫࡣᚑ᮶ 3 ࡘࡢ✀ෆศ㢮⩌ ศࡅࡽࢀ࡚࠸ࡓࡀࠊࡑࡢ᰿ᣐ ࡉࢀࡓⴥ㠧ࡢẟࡢᛶ≧ࡣ㞟ᅋෆ࡛ࡶኚ␗ࡀࡁ࠸ ࡇࢆ᫂ࡽࡋࠊࡇࢀࡲ࡛ኚ✀ࡉࢀ࡚ࡁࡓ ࣡࢟ࣀ࢞ࣜࣖࢫࢆ⊂❧ศ㢮⩌ࡋ࡚ㄆࡵࡎࠊ࢜ࢽ ࣀ࢞ࣜࣖࢫྵࡵࡿࡶࡢࡋࡓࠋࡲࡓࠊ୍⯡ⓗ ࡣཷࡅධࢀࡽࢀ࡚࠸࡞ࡗࡓ࢜ࢡ࢚ࢰ࢜ࢽࣀ࢞ࣜ ࣖࢫࢆ᳨ウࡋࠊᆅ⌮ศᕸࡀ᪉೫ࡿࡇⴥ㠧 ࡀ↓ẟ࡛࠶ࡿ࠸࠺㝿❧ࡗࡓ≉ᚩࡽࠊ࢜ࢽࣀ࢞ ࣜࣖࢫࡢ㸯ရ✀ࡋ࡚ㄆࡵࡓࠋ ࡲࡓࠊᾏ㐨ᮾ㒊ࡢ‵ཎ࠾࠸࡚ࠊໟ✛ࡢ❳㦵 ୖࡢ✺㉳ࡀ㛗࠸࣡ࣀ࢞ࣜࣖࢫࡢኚ␗ಶయࢆ☜ㄆ ࡋࠊࣟࢩࡢ࢘ࣛࢪ࢜ࢫࢺࢡ࠶ࡿ VLA ಖ⟶ࡉ ࢀ࡚࠸ࡿ C. amurensis ྠ୍࡛࠶ࡿࡇࢆ᫂ࡽ ࡋࡓࠋࡇࡢࡇࡼࡾࠊࡇࢀࡲ࡛ᴟᮾࣟࢩ ࡋศᕸࡋ࡞࠸ࡉࢀ࡚ࡁࡓ C. amurensis ࡀᾏ 㐨ࡶศᕸࡍࡿࡢࢆึࡵ࡚᫂ࡽࡋࡓࠋࡉࡽࠊ ⰼჾᙧែࡢ≉ᚩࡽࠊC. amurensis ࢆ⊂❧✀࡛ࡣ࡞ ࡃࠊC. pupurea ࡢள✀ࡋ࡚⤌ࡳ࠼ࡓࠋྡ᪂⛠ ࡣ࣒࣮ࣝ࣡ࣀ࢞ࣜࣖࢫࡋࡓࠋࡲࡓࠊᾏ㐨 ᮾ㒊ࡢ‵ཎ࠾࠸࡚ࠊࡇࡢள✀ఝࡿࡀࣟࢩࡢ ሗ࿌࡛ࡣᰁⰍయᩘࡀ 2n=42 ࡢ 6 ಸయ 2n=56 ࡢ 8 ಸయࡀ▱ࡽࢀࡿ࣒࣮ࣝ࣡ࣀ࢞ࣜࣖࢫࡣ␗࡞ ࡾࠊ2n=28 ࡢ 4 ಸయࢆ♧ࡍಶయࢆぢฟࡋࡓࠋࡇࡢ ಶయࡣ࣒࣮ࣝ࣡ࣀ࢞ࣜࣖࢫࡣ␗࡞ࡾࠊⰼᗎ ࡢᯞࡢᇶ㒊ࡀ᭷ẟ࡛࠶ࡿ≉ᚩࢆ♧ࡋ࡚࠾ࡾࠊࡇࢀ ࢆ࣒࣮ࣝ࣡ࣀ࢞ࣜࣖࢫࡢ᪂ရ✀ࢵࢣࢩ࣡ ࣀ࢞ࣜࣖࢫ f. akkeshiensis ࡋ࡚グ㍕ࡋࡓࠋ ࡑࡢࠊᾏ㐨ᮾ㒊ࡢ㔲㊰‵ཎูᐮ㎶∵‵ཎ ࠾࠸࡚ࠊ㧗ᒙ‵ཎపᒙ‵ཎࡀ᥋ࡍࡿ୰㛫‵ཎ ࠊ࣡ࣀ࢞ࣜࣖࢫࢳࢩ࣐࢞ࣜࣖࢫࡢ୰㛫ᆺࡀ ⏕⫱ࡋ࡚࠸ࡿࡇẼ࡙ࡁࠊእ㒊ᙧែࠊᰁⰍయᩘࠊ ⰼ⢊ࢧࢬ࣭ⰼ⢊⛱ᛶࢆㄪࡓࠋࡑࡢ⤖ᯝࠊእ㒊 ᙧែ࡛ࡣࡼࡃఝࡿࢳࢩ࣐࢞ࣜࣖࢫ2n=84 (X=12) ࡣ␗࡞ࡾࠊ୰㛫ᆺࡣ2n=56㸦X=8㸧ࢆ♧ࡋࠊᰁⰍయ ᩘࡀࢳࢩ࣐࢞ࣜࣖࢫࡣ␗࡞ࡗ࡚࠸ࡓࠋࡑࡇ࡛᥎ ᐃ୧ぶ✀࡛࠶ࡿ࣡ࣀ࢞ࣜࣖࢫ2n=28, 42, 56㸦X=4, 6, 8㸧ࢳࢩ࣐࢞ࣜࣖࢫ2n=84 (X=12)ࡢ≉ᚩࡢ㐪 ࠸ࢆẚ㍑ࡋࡓࠋࡇࢀࡲ࡛ࡢሗ࿌࠶ࡿ࠾ࡾࠊ ࣡ࣀ࢞ࣜࣖࢫࡢ㧗ḟಸᩘయ࡛ࡣⰼ⢊ཬࡧⵂࢆᙧᡂ ࡏࡎࠊ4ಸయࡢࡳⰼ⢊ࢆᚓࡽࢀࡓࠋእ㒊ᙧែ࡛ࡣࠊ ୰㛫ᆺࡣ࣡ࣀ࢞ࣜࣖࢫࡢࡼ࠺ⰼᗎࡢᯞࡀ㛗࠸ ࡀୗᆶࡏࡎࠊⲡࡀࢳࢩ࣐࢞ࣜࣖࢫࡼࡾࡁ࠸≉ ᚩࢆ♧ࡋࠊⰼ⢊ࢧࢬࡣ୰㛫ᆺࡢಶయࡼࡗ࡚ࡣࠊ ࣡ࣀ࢞ࣜࣖࢫᆺࡢⰼ⢊ࢳࢩ࣐࢞ࣜࣖࢫᆺࡢⰼ ⢊ࢆᙧᡂࡋࠊ୧᪉ࡢᆺࡢⰼ⢊ࢆᣢࡘಶయࡶ☜ㄆࡋ ࡓࠋࡲࡓࠊ࠸ࡎࢀࡢᆺࡶⰼ⢊⛱ᛶࡣపࡃࠊ4ಸయࡢ ࣡ࣀ࢞ࣜࣖࢫࡢࡼ࠺࡞㧗࠸ⰼ⢊⛱ᛶࡣぢࡽࢀ࡞ ࡗࡓࠋࡇࢀࡽࡢ≉ᚩࡽࡇࢀࢆ࣡ࣀ࢞ࣜࣖࢫ ࢳࢩ࣐࢞ࣜࣖࢫࡢ⮬↛㞧✀ࡋ࡚ㄆࡵࡓࠋࡇࡢ ⤌ࡳྜࢃࡏࡣࠊᴟᮾࣟࢩ࡛ㄆࡵࡽࢀ࡚࠸ࡿ㞧✀ C. ×subneglectaྠࡌ⤌ࡳྜࢃࡏ࡛࠶ࡾࠊᮏ㞧✀ࡀ ᪥ᮏࡶศᕸࡋ࡚࠸ࡿࡇࢆ᫂ࡽࡋࡓࠋ − 37 − ㄽᩥⓎ⾲ Sato, H. and Takahashi, H. 2015䠊Variation in the hairiness of the leaf sheath of Calamagrostis gigas (Poaceae). 㻌 The Journal of Japanese Botany 90: 386–398. Sato, H. and Takahashi, H. ༳ๅ୰㸬Calamagrostis purpurea subsp. amurensis (Poaceae) and its new form in Eastern Hokkaido, Japan. ᡂ◊✲ᶵᵓ ◊✲ேᮦ⫱ᡂ᥎㐍ᐊ ⏣୰ ᬸ᫂ 㸦ᾏỈ⏝㸧 Ⓨ⾲ㄽᩥ Koizumi, M., Shigeno, S., Mizunami, M., Tanaka, NK. Three-Dimensional Brain Atlas of Pygmy Squid, Idiosepius paradoxus, revealing the Largest Relative Vertical Lobe System Volume Among the Cephalopods. J Comp Neurol, in press. ᏛⓎ⾲ Nobuaki Tanaka, Motoki Koizumi 㸸 Brain atlas of pygmy squid, Idiosepius paradox. ᪥ᮏ⚄⤒⛉ᏛᏛ➨ 38 ᅇ 2015 ᖺ 7 ᭶ 28 ᪥ࠊ ⚄ᡞᅜ㝿㆟ሙ㸦⚄ᡞᕷ㸧 ᑠἨඖẎࠊ⏣୰ᬸ᫂㸸ࣄ࣓࢝⬻ࡢ㸱D ࢺࣛࢫ 㢌㊊㢮⬻ࡢ࢝ࣝࢩ࣒࣭࣓࣮࢘ࢪࣥࢢἲࡢ☜❧ ࡘ࠸࡚ࠋ ᪥ᮏື≀Ꮫ➨ 86 ᅇ 2015 ᖺ 9 ᭶ 19 ᪥ ᪂ ₲ࢥࣥ࣋ࣥࢩࣙࣥࢭࣥࢱ࣮㸦᪂₲ᕷ㸧 Koizumi,M.,Shigeno,S. Tanaka, N. :Three-dimensional brain atlas of pygmy squid, Idiosepius paradoxus. Cephalopod International Advisory Council meeting. 11/9, 2015. Hakodate International Hotel, Hakodate, Japan. − 38 −
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