Graft Versus Host Disease (GvHD) Market Demands and Growth Prediction 2018 to 2026

Graft Versus Host Disease (GvHD) Market Headed
for Growth and Global Expansion by 2026
Graft Versus Host Disease (GvHD) Market - Global Industry Insights, Trends,
Outlook, and Opportunity Analysis, 2018-2026
During any transplant of stem cell and bone marrow some complications arises that may be mild or
severe, those are the graft versus host disease (Gvhd) they occur especially in immune-compromised
patients. During cancer treatment, the radioactive agents or the chemicals affects the healthy cells along
with the cancer cells. Reconstruction of body cells affected during cancer treatment can be fixed using
stem cell and bone marrow transplant. Following a high dose of chemotherapy, the bone marrow is
received by patient the donor through infusion, which helps with resumption of blood cells production.
Click To Read More On Graft Versus Host Disease (GvHD) Market.
Graft versus host disease occurs when particular type of white blood cells are not compatible with the
existing cell type and thus, leads to an attack by the transplanted cells on the recipient body. It is a
difficult procedure to diagnose the agents and the compatibility during the transplant. Symptoms of
Gvhd are usually not too severe, though in some cases it can be fatal. During autologous transplant, the
patient is free from such complications. Also, prior to the transplant, cells of the donor and recipient are
closely screened and matched so as to avoid Gvhd by ensuring the closest possible match.
High investment in research and development is expected to favor growth of the graft versus host
disease market:
In the recent past, the graft versus host disease market has significantly evolved with the introduction
of biological and patented small molecule immunosuppressive therapies and been added to the
treatment regime. The current research and development programs in Gvhd are equipped with novel
therapies such as Adienne Pharma’s Begedina and mesenchymal stem cell therapies. R&D strategies in
Gvhd are characterized by an increasing trend towards maintaining appropriate prophylactic regimens
and inhibiting proliferation and activation of T-cell. Such regimens in Gvhd are tailored to conditioning
and transplant type and used for hematopoietic stem cell transplantation (HSCT). However, there is
significant possibility of risk of opportunistic infection during this process.
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However, most of the ventures in research and development process, including academically running
clinical studies regarding targeting niche subgroup under Gvhd such as steroid refractory aGVHD and
cGVHD, are key R&D strategies in the GVHD pipeline, with around 30 products in the pipeline
targeting such populations. Extensive research and development activities are expected to favor growth
of the graft versus host disease industry in the near future.
Market players in the GvHD market focusing on inorganic growth strategies to strength product
portfolio
The global graft versus host disease market is competitive and fragmented. Major players in the market
are developing novel products and spending significantly in research and development, along with
major acquisitions and collaborations to achieve competitive edge over their counterparts. For instance,
Kalytera Therapeutics, Inc. acquired Talent Biotechs Ltd. – an Israeli-based developer of proprietary
cannabidiol therapeutic. This is expected to favor the increase in company’s product portfolio. Some of
the key players in the Gvhd market are Sanofi, Novartis AG, Neovii Biotech GmbH, Merck & Co.,
Astellas Pharma Inc., Soligenix, Inc., and Mesoblast Ltd.
Lack of regulatory guidelines pegs back growth of graft versus host disease market
The disease is orphan in nature, which can be one of the important factors affecting the lack of
guidelines and treatment regimes. Lack of randomized clinical trials is another factor that contributes
towards non-popularity of Gvhd due to the use of variable clinical trial endpoints conducted studies till
date. This has resulted in inappropriate clinical evidences, which are not comparable and not directly
applicable to all Gvhd patient groups. However, advancements in the process of early detection of
symptoms is projected to support growth of the graft versus host disease market in the near future.
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During any transplant of stem cell and bone marrow some complications arises that may be mild or severe, those are the graft versus host disease (Gvhd) they occur especially in immune-compromised patients. During cancer treatment, the radioactive agents or the chemicals affects the healthy cells along with the cancer cells.

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