Metastatic Osteosarcoma Treatment Market

Metastatic Osteosarcoma Treatment Market - Global
Industry Insights, Trends, and Opportunity Analysis
2018–2026
Osteosarcoma or bone cancer is a type of cancer were bone tissues show an abnormal growth.
Osteosarcoma that spreads from initially affected area to distant site is known as metastatic
osteosarcoma. Metastatic osteosarcoma often spreads to lungs, whereas less commonly spreads
to other bones, brain or other organs. Symptoms of metastatic osteosarcoma varies based on the
location of tumor, for example bone pain, bone fracture, swelling, redness, limping, and limited
joint movement. If the tumor spreads to the lungs the symptoms include chest pain, shortness
of breath, cough with blood, chronic coughing or wheezing. Diagnostic tests for metastatic
osteosarcoma includes CT-scan, MRI, X-ray, PET scan, biopsy, and bone scan. Treatment of
metastatic osteosarcoma involves surgery, radiation, chemotherapy, biological therapy or a
combination of these treatments. Combinational treatment also known as multi-modality
treatment is more preferred by medical practitioners to increase treatment outcomes or to
prolong survival.
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Metastatic Osteosarcoma Treatment Market – Drivers
Increasing drug pipeline for malignant bones and soft tissue (Ewing Sarcoma) cancer is expected
to drive growth of metastatic osteosarcoma treatment market. For instance, in 2017, Merck &
Co., Inc., studies the effects of Pembrolizumab (MK-3475) in patients with relapsed or
metastatic osteosarcoma and reported that these patient are not eligible for curative surgery.
Currently, study is in phase II clinical trial and is expected to be marketed in 2023. Moreover,
Novartis entered into phase II clinical trials for pazopanib for treatment of metastatic
osteosarcoma as of March 2018.
Emerging new therapies for metastatic osteosarcoma treatment will further propel growth of the
market. For instance, clinical trials for immunotherapy-based drugs and targeted drug therapy is
expected to be a preferred option in the near future, owing to less side-effects. The immune
therapy drug called immune checkpoint inhibitors can recognize and attack cancer cells
exhibiting better outcomes for other cancer types and also studies have showed it is also
effective for osteosarcoma treatment. Moreover, engineered monoclonal antibodies are used to
stop cancer growth by hampering new blood vessel formation or to inhibit tumor cells by
targeting mTOR protein. For instance, Aadi, LLC studies Nivolumab (Opdivo) in combination
with ABI-009 (Nab-rapamycin, the mTOR inhibitor) for potential anti-tumor activity for Ewing
Sarcoma. The study is in phase II clinical trial, which is expected to complete by 2020.
In case of pediatric osteosarcoma, around 35% of patient fail first-line of therapy, leading to
recurrence in metastatic osteosarcoma in lungs. Therefore, development of novel drugs for
treatment of lung cancer, due to metastatic osteosarcoma will also contribute to growth of the
metastatic osteosarcoma treatment market. For instance, in 2013, Elesion Pharmaceuticals LLC,
a pharmaceutical company developing life-saving therapeutics for rare cancers, entered into
phase II clinical trials for Inhaled Lipid-complexed Cisplatin (ILC), a novel sustained release
formulation of cisplatin in a nanoscale lipid based complex, for pediatric patients with
osteosarcoma metastases for lungs. Additionally, inorganic marketing strategies adopted by
metastatic osteosarcoma drug market players is expected to aid in the market growth. For
instance, in the same year, Inhaled Lipid-complexed Cisplatin orphan drug designation by
European Medicines Agency for the treatment of osteosarcoma. Furthermore, in 2015, company
entered in partnership with Intelgen Limited, a Hong Kong-based biopharmaceutical company,
for specialized novel anti-cancer drug development and commercializing ILC in Chinese market.
Moreover, in 2014, Oncolytics Biotech, examined safety and efficacy of Reolysin for the
treatment of bone and soft tissue sarcoma metastatic for lungs.
Report includes chapters which deeply display the following deliverable about industry :
• Metastatic Osteosarcoma Treatment Market Research Objective and Assumption
• Metastatic Osteosarcoma Treatment Market Purview - Report Description, Executive Summary,
and Coherent Opportunity Map (COM)
• Metastatic Osteosarcoma Treatment Market Dynamics, Regulations, and Trends Analysis Market Dynamics, Regulatory Scenario, Industry Trend, Merger and Acquisitions, New system
Launch/Approvals, Value Chain Analysis, Porter’s Analysis, and PEST Analysis
• Global Metastatic Osteosarcoma Treatment Market, By Regions
• Metastatic Osteosarcoma Treatment Market Competition by Manufacturers including
Production, Share, Revenue, Average Price, Manufacturing Base Distribution, Sales Area and
Product Type.
• Metastatic Osteosarcoma Treatment Market Manufacturers Profiles/Analysis including Company
Basic Information, Manufacturing Base and Its Competitors.
• Metastatic Osteosarcoma Treatment Market Manufacturing Cost Analysis including Key Raw
Materials and Key Suppliers of Raw Materials.
• Industrial Chain, Sourcing Strategy and Downstream Buyers including Upstream Raw Materials
Sourcing and Downstream Buyers
• Marketing Strategy Analysis, Distributors/Traders including Marketing Channel, Market
Positioning and Distributors/Traders List.
• Market Effect Factors Analysis including Technology Progress/Risk, Consumer Needs/Customer
Preference Change and Economic/Political Environmental Change.
• Metastatic Osteosarcoma Treatment Market Forecast including Production, Consumption,
Import and Export Forecast by Type, Applications and Region.
• Research Findings and Conclusion
Metastatic Osteosarcoma Treatment Market – Restrain
Growth of the metastatic osteosarcoma treatment market can be hindered by availability of
alternative therapies such as new forms of radiation therapy (intensity-modulated radiation
therapy, stereotactic radiosurgery or conformal proton beam therapy). Moreover, stringent
approval policies for varies drug therapies is also expected to adversely affect growth of the
market.
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Metastatic Osteosarcoma Treatment Market - Regional Analysis
Based on geography, the metastatic osteosarcoma treatment market has been segmented into
North America, Latin America, Europe, Middle East, Asia Pacific, and Africa. North America
holds dominant position in the global metastatic osteosarcoma treatment market over the
forecast period, owing to increasing research and developmental activities and increasing
pipeline products by market players such as Novartis and Merck & Co. Inc. Moreover, high
osteosarcoma incidence contribute to the share. For instance, in 2016, American Society of
Clinical Oncology (ASCO), estimated 1,000 people to be diagnosed with osteosarcoma each year.
However, Asia Pacific is expected to witness fast growth in metastatic osteosarcoma treatment
market, due to increasing incidence of osteosarcoma in the region.
Metastatic Osteosarcoma Treatment Market – Competitor
Key players operating in the metastatic osteosarcoma treatment market are Mylan Laboratories
Limited, Actavis Inc., Alvogen Inc., Gland Pharma Limited, Sagent Pharmaceuticals Inc., Sun
Pharmaceutical Industries Ltd., Dr Reddy’s Laboratories Ltd., and Luitpold Pharmaceuticals Inc.
Metastatic Osteosarcoma Treatment Market – Taxonomy
By Drug Type
• Doxorubicin
• Dactinomycin
• Denosumab
• Ifosfamide
• Cyclophosphamide
• Carboplatin
• Others
By Distribution Channel
• Hospital Pharmacies
• Retail Pharmacies
• Online Pharmacies
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Osteosarcoma or bone cancer is a type of cancer were bone tissues show an abnormal growth.