DNA Repair Drugs Market

DNA Repair Drugs Market – Size, Share, Outlook,
and Opportunity Analysis, 2019 – 2026
DNA can be damaged due to endogenous factors (oxidation) or exogenous factors (UV radiations
or viruses), but our cell can identify and repair the damage. However, when the repairing
mechanism of the cell fails, it leads to dysfunctionality or mutations in the DNA of the cell. It
can also lead to abnormal growth of cells, i.e., cancer. Such irreparable damage can be treated
with DNA repair drugs such as poly ADP-ribose polymerase inhibitors (PARP). PARP blocks the
activity of ADP-ribose polymerase proteins, thus preventing the replication of cancer cells.
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Global DNA Repair Drugs Market Drivers
Increasing collaboration and acquisition activities are expected to boost the global DNA repair
drugs market growth. For instance, in January 2017, Merck KGaA entered into a licensed
agreement with Vertex Pharmaceuticals Inc., for four research developments on approaches to
cancer. The reason for the partnership was to strengthen Merck’s area of DNA damage response
and immuno-oncology. Furthermore, in February 2016, Onxeo, an orphan oncology therapeutics
company, acquired DNA Therapeutics, a biopharmaceutical company for its DNA repairing
technology for treatment of cancer. This technology consists of a signal interfering DNA
molecule (siDNA), and Onxeo S.A. intends to develop this technology as a potential treatment
option for cancer. Such partnerships are expected to propel the global DNA repair drugs market
growth.
Moreover, frequent research and development activities are expected to propel the global DNA
repair drugs market growth. For instance, in October 2018, Pfizer began conducting a trial of
talazoparib drug for the treatment of triple negative breast cancer. Currently, it’s in second
phase of clinical trial and it is a type of monotherapy. Furthermore, there are many other
products that are in pipeline. For instance, in February 2019, BeiGene began with its clinical
trials of pamiparib for the treatment of metastatic prostate cancer. The trial of pamiparib is
currently in its second phase. Such key researches are expected to boost the global DNA repair
drugs market growth.
Global DNA Repair Drugs Market Regional Analysis
North America is expected to hold a dominant position in the global DNA repair drugs market.
Factors such as increasing research and development activities are expected to have an influence
on the North America’s DNA repair drugs market growth. For instance, in 2017, Harvard
Medical School and University of South Wales conducted a study on DNA repair drugs for
treatment of radiation damage that causes cancer. They have discovered the mechanism that
weakens the system of our cell’s capability to repair the damages. They developed a drug,
which was tested on mice and the mice were successfully able to retrieve the cell functions.
The successful development of such researches is expected to propel the global DNA repair drug
market growth.
Report includes chapters which deeply display the following deliverable about industry :
• DNA Repair Drugs Market Research Objective and Assumption
• DNA Repair Drugs Market Purview - Report Description, Executive Summary, and Coherent
Opportunity Map (COM)
• DNA Repair Drugs Market Dynamics, Regulations, and Trends Analysis - Market Dynamics,
Regulatory Scenario, Industry Trend, Merger and Acquisitions, New system Launch/Approvals,
Value Chain Analysis, Porter’s Analysis, and PEST Analysis
• Global DNA Repair Drugs Market, By Regions
• DNA Repair Drugs Market Competition by Manufacturers including Production, Share,
Revenue, Average Price, Manufacturing Base Distribution, Sales Area and Product Type.
• DNA Repair Drugs Market Manufacturers Profiles/Analysis including Company Basic
Information, Manufacturing Base and Its Competitors.
• DNA Repair Drugs Market Manufacturing Cost Analysis including Key Raw Materials and Key
Suppliers of Raw Materials.
• Industrial Chain, Sourcing Strategy and Downstream Buyers including Upstream Raw Materials
Sourcing and Downstream Buyers
• Marketing Strategy Analysis, Distributors/Traders including Marketing Channel, Market
Positioning and Distributors/Traders List.
• Market Effect Factors Analysis including Technology Progress/Risk, Consumer Needs/Customer
Preference Change and Economic/Political Environmental Change.
• DNA Repair Drugs Market Forecast including Production, Consumption, Import and Export
Forecast by Type, Applications and Region.
• Research Findings and Conclusion
Global DNA Repair Drugs Market Restraints
Failure of drugs in late stages of clinical trials has hampered the global DNA repair drugs
market growth. For instance, in April 2017, Veliparib, a product by AbbVie was withdrawn
from both the clinical trial studies. One of the clinical trial study involved the drug’s efficacy
on breast cancer and other for lung cancer. Veliparib was treated with a combination of
chemotherapy for both, lung and breast cancer treatment. Both of the trials were withdrawn at
its third phase. Such failures may hinder the global DNA repair drugs market growth.
High costs of drugs are expected to hinder the global DNA repair drugs market growth.
Manufacturers are focused on offering a highly effective drug, thus investing more into research
and development activities. This factor further adds up into final cost price of the product. For
instance, a Lynparza tablet of 50 mg costs around US$ 32. Such high cost would be an
obstruction in the developing regions such as Africa, Latin America, and Asia-Pacific for the
global DNA repair drugs market growth.
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Global DNA Repair Drugs Market Key Players
Some of the major players operating in the global DNA repair drugs market include 4SC AG,
Artios Pharma, Johnson & Johnson Service Inc., GlaxoSmithKline plc, Genentech, Inc., Sierra
Oncology Inc., AstraZeneca, Karyopharm Therapeutics, Jiangsu Hengrui Medicine Co., Ltd., and
Merck KGaA.
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DNA can be damaged due to endogenous factors (oxidation) or exogenous factors (UV radiations or viruses), but our cell can identify and repair the damage.