Silver-haired Bat (Lasionycteris noctivagans) • Vector of cryptic rabies virus • 1990-2002: ~70% of 33 reported human rabies cases in the US • Only 2 cases had a history of bat bite Plant System For High-Yield Production of Recombinant Subunit Vaccines Vaccine Production in Plants Safety Cost-efficiency Easy scale-up Proper glycosylation Suitable for developing countries Possible direct delivery RABIES VIRUS NEUTRALIZING TITERS OF HUMAN SERA 10000 9000 8000 7000 6000 5000 4000 3000 2000 1000 0 Pre-I Pre-B Post-B 1 2 CONTROL 3 4 5 6 7 8 EXPERIMENTAL BIOMEDICALS FOR DISEASE PROPHYLAXIS AND TREATMENT EXPRESSED IN PLANTS AT THE BIOTECHNOLOGY FOUNDATION LABORATORIES DISEASES PLANT VACCINE Tobacco Tomato Cauliflower ● ● Tobacco Tomato Spinach ● ● ● Respiratory Syncytial Virus (RSV) Tobacco Swiss Chard ● ● Smallpox Collard Swiss Chard ● ● Diphtheria, Pertussis, Tetanus (DPT) Carrot Tobacco ● Rabies Spinach Collard Tobacco ● ● ● Spinach ● Barley (recently initiated) Lettuce Cauliflower ● ● Tobacco ● Severe Acute Respiratory Syndrome (SARS) Anthrax HIV Avian Influenza Hepatitis B Colorectal and Breast Cancer Antibody ● ● ● COMPARATIVE COSTS OF ANTI-RABIES ANTIBODIES COMPANY NAME PRODUCT SOURCE PRODUCT DESCRIPTION PRODUCT Bayer BayRab Human Donors human anti-Rabies immunoglobulins 1500 iu $1,125. Aventis IMOGAM Rabies-HT Human Donors anti-Rabies immunoglobulins (10-18% protein) 1500 iu $ 847. wholesale price AbCam ab10014 Mouse Cells Biotechnology MAb57 Foundation, Inc. Tobacco monoclonal mouse antibodies monoclonal mouse PRICE 100 µg $ 250. 100 µg $ 0.5 -$1.
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