Frontier Pharma Diabetic Complications - Innovative and Diverse Neuropathies, Nephropathy and Retinopathies Pipelines Demonstrate Shift Towards Disease Modifying Therapies

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Frontier Pharma: Diabetic Complications - Innovative and Diverse
Neuropathies, Nephropathy and Retinopathies Pipelines Demonstrate
Shift Towards Disease Modifying Therapies
Diabetes is a common long-term condition that can lead to a range of disparate and serious complications.
It is a lifelong, multi-systemic condition that affects a number of integral organs. Diabetes has a rapidly
increasing prevalence – it currently affects 10% of adults globally, and is estimated to become the seventhleading cause of death by 2030.
The lack of absolute treatment for the condition and the difficulty in maintaining constant glycemic
control, even following adequate treatment, can result in a range of complications. The three main
indication groups are diabetic nephropathy, which is a progressive condition caused by damage to the
capillaries and kidneys glomeruli as a result of diabetes; diabetic retinopathy, which is defined as damage
to the retina as a result of high blood sugar; and a range of diabetic neuropathies, a group of conditions
in which nerve damage is caused as a result of diabetes mellitus.
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The diabetic complications pipeline consists of 429 products that contain an array of targets not currently
in use within the market. The increase in molecular target diversity signifies the high potential for changes
and improvements in the diabetic complications market. One innovative therapy is CBX-129801, a
promising synthetic peptide that is currently in development for diabetic neuropathy. Innovation can also
be seen within diabetic retinopathy, with therapies such as BCN070660, a topical ophthalmologic
formulation currently in development.
Scope
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- What effect do current market therapies have on disease progression?
- Which drug classes dominate the current market?
- What additional benefits have newly approved therapies brought to the market?
- Can the increasing number of peptides in the pipeline prove useful in diabetic neuropathy?
- Can neuroprotective therapies prove an important addition in diabetic retinopathies?
- Can the diverse range of molecule types and molecular targets within the pipeline help reverse disease
progression?
- To what degree is the pipeline penetrated by first-in-class innovation?
- What is the clinical potential of first-in-class products, based on their alignment to disease-causing
pathways?
- Which are the most promising first-in-class targets in early-stage development?
- Which of the first-in-class products in development are not currently involved in a licensing or codevelopment deal, and therefore represent investment opportunities?
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Reasons to buy
- Understand the current clinical and commercial landscape. It includes a comprehensive study of
disease pathogenesis, diagnosis, prognosis and the treatment options available.
- Visualize the composition of the market for each diabetic complication individually, in terms of
dominant molecule types and targets, highlighting what the current unmet needs are and how they can
be addressed. This knowledge allows a competitive understanding of gaps in the current market.
- Analyze the pipeline for each diabetic complication individually and stratify by stage of development,
molecule type and molecular target. There are strong signs in the pipeline that the industry is seeking
more innovative approaches to treating diabetic complications.
- Assess the therapeutic potential of first-in-class targets. Using a proprietary matrix, first-in-class
products have been assessed and ranked according to clinical potential. Promising early-stage targets
have been reviewed in greater detail.
- Identify commercial opportunities in the diabetic complications deals landscape by analyzing trends in
licensing and co-development deals and producing a curated list of diabetic complications therapies that
are not yet involved in deals, and may be potential investment opportunities.
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Connect for more details:
Sam Collins
Market Reports Center
1-646-883-3044 (US)
[email protected]
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Diabetes is a common long-term condition that can lead to a range of disparate and serious complications. It is a lifelong, multi-systemic condition that affects a number of integral organs.