Faculty SUPPORTED BY AN UNCONDITIONAL EDUCATIONAL SPONSORSHIP FROM Updating on Circulating Tumor Cells Aieta Michele, IRCCS-CROB, Rionero in Vulture (PZ), Italy Amadori Alberto, IOV-IRCCS, Padova, Italy Basso Umberto, IOV-IRCCS, Padova, Italy Bonciarelli Giorgio, Direttore U.O.C. Oncologia Medica, Este, Italy in cancer patients management Buonocore Caterina, Agenzia Promozione della Ricerca Europea, Roma, Italy 2 nd 20 14 Chiarion-Sileni Vanna, IOV-IRCCS, Padova, Italy Conte PierFranco, University of Padova, IOV-IRCCS, Padova, Italy be r2 Cristofanilli Massimo, Jefferson Breast Care Center at the Kimmel Cancer Center (KCC) and Thomas Jefferson University and Hospitals, Philadelphia, USA Grisanti Salvatore, Spedali Civili di Brescia, Italy Ijzerman Maarten, HTSR University of Twente, Netherlands Munzone Elisabetta, IEO, Milano, Italy Opocher Giuseppe, Istituto Oncologico Veneto IRCCS, Padova, Italy ECM - CONTINUING MEDICAL EDUCATION (C.M.E.) FOR ITALIAN PARTECIPANTS ONLY Terstappen Leon W. M. M., HTSR University of Twente, Netherlands 3 C.M.E. credits have been assigned for: biologist, pharmasist, medical technician biomedical laboratory and medical radiology, doctor (all medical disciplines), nurse. Zagonel Vittorina, IOV-IRCCS, Padova, Italy CONFERENCE VENUE Zamarchi Rita, IOV-IRCCS, Padova, Italy Auditorium San Gaetano Via Altinate, 71- Padova Pantano Francesco, Università Campus Bio-Medico, Roma, Italy y, S There is no registration fee, but advanced registration is required. All registration must be submitted online: www.events-communication.net/circulatingtumorcells Official language is English. da Gennari Alessandra, Galliera Hospital, Genova, Italy on REGISTRATION M Gazzaniga Paola, Università La Sapienza, Roma, Italy ep te m Foroni Chiara, Istituti Ospitalieri Cremona, Italy ORGANIZING SECRETARIAT Events congress&communication Via Mantegna, 1 - 60019 Senigallia (AN) Tel +39 071.7930220 - Fax +39 071.9252094 [email protected] www.events-communication.net Auditorium San Gaetano p INTRODUCTION The meeting aims to update the participants on the use of the CTC assay in cancer patients, ten years later the first published report on its prognostic and predictive value in metastatic breast cancer. To this purpose, we invited the speakers among the Italians who have already used the CTCs in different cancers. Furthermore, we will open the seminar with talks by the greatest CTC experts to give an international-scale profile to the conference. The focus of the meeting will be as following: 1) To sharing the knowledge of European metanalysis results on the CTC use in MBC; 2) To involve all stakeholders in debating the use of CTC assay as companion diagnostic, including: the health professionals, the Health Technology Assessment service of public hospitals of Veneto region, the Regional authorities that establish the reimbursement of new diagnostic tests, the regulatory authorities of the Italian drug agency; 3) To present the opportunities offered by the European financial support (Horizon 2020) toward proposals of translational medicine for cancer patients that include the CTC assay or the study of circulating compartment. Through this initiative, we expect to increase the network of our research collaborations around the CTC theme. ORGANIZING COMMITEE Dr.ssa Rita Zamarchi U.O.C. Immunologia e Diagnostica Molecolare Oncologica IOV-IRCCS Padova r o g 8.30 Participants’ Registration 9.00 Welcome address General Manager IOV-IRCCS Scientific Director IOV-IRCCS 1st SESSION CHAIRS: A. Amadori, G. Opocher 9.15 CTCs and breast cancer ten years later M. Cristofanilli 9:45 The biomarkers in the target drug era TBD (an expert of AIFA, the Italian Agency for drug approval) 10.15 New perspectives in CTCs investigation L. W. M. M. Terstappen r 10.45 Discussion 11.00 Coffee break 2nd SESSION CHAIRS: V. Zagonel, R. Zamarchi 11.15 Employ of CTCs in clinical trials: the Myme study experience A. Gennari 11.35 RANK expression on CTCs in metastatic breast cancer F. Pantano 11.55 Prognostic value of CTC detection in high-risk Non-Muscle Invasive Bladder Cancer P. Gazzaniga 12.15 Economic impact of news biomarkers in the management of cancer patients M. Ijzerman 12.45 Discussion 13.15 Lunch a m m a 3rd SESSION CHAIRS: V. Chiarion-Sileni, P. Conte 14.15 A case report: detection of EML4-ALK positive CTCs in an adenocarcinoma of lung M. Aieta 14.30 A case report: CTC detection in a locally advanced head and neck cancer S. Grisanti 14.45 A case report: CTC use in adjuvant setting E. Munzone 15.00 A case report: CTCs’ changes in a MBC patients under zoledronic acid (ZA) C. Foroni 15.15 A case report: the detection of CTCs anticipates the knowledges of disease recurrence in MBC G. Bonciarelli 15.30 A case report: changes of CTC and CEC levels in a mRCC cancer patient under pazopanib treatment U. Basso 15.45 A case report: detection of KIT mutation in Circulating Melanoma Cells (CMCs) V. Chiarion-Sileni 16.00 New topic for greater opportunities in drafting proposals for NCP Horizon 2020 Health programme C. Buonocore 16.30 Round table with the experts V. Chiarion-Sileni, P. F. Conte, M. Cristofanilli, P. Gazzaniga, A. Gennari, F. Pantano 17.30 Closing remarks and ECM test
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