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"#$ %& '( RC klmnRC-.x;NO% )*+,)-.'(/ 70<o0GM8 b !"01#234$5 90 FPklmnRC 2%%67( &8'9 834QC6 -.% ()* ):+,; feeding ves- sel sign -./00< 1. "=$>?@A (pneumatocele) B,C Mycoplasma pneumoniae ? lipoprotein D 1 E : F G H : F I check Q(BR80B, STUVW valve JKLM;&NOP2NO XY BRZ[SVW\] I ?8^_O`; SVW\]?8^_;6 :Fa IV ; 34QC (atypical pneumonia) b-RST 9)*So7S+,/0C8] UVW,56X0 Y/Z7[%; \ :F):dGHw8C RU89]^,_L'(0 B,`a^: BReo7:FC8%; >cdeRf> ;bC<= Mycoplasma pneumo- C(,af/0ghg niae C >cdeRf>C Chlamydophila f/g %Oi'( 7(% pneumoniae C SRghijRC >?/ 9af/g,O`¡¢'( @0C8];A7( Legionella £¤¥jk¦ 17) f/ pneumophila C klmnRC b-RSTU g,? lipoprotein >S§i¨$l VW,56X \RU89]^,_L' Toll-like receptors (TLRs) 8©;/ (0 -./0BC8D;o7MpE hg 18ª20) 14 EFBC:;s»¼ Vol. 19 No. 2 2009. b c8C8]; CT [v H 8. )*+,-.) HRCT D° ¦ G ± ² @F MNO"PMNO8J ! S DS³F MN8& &bc-d +C^<_>`aC 1 DS³´ µ¶F H 9. 81 w-;xyz- 66 ·T CT DUMF 23 DS³F != DS³´ µ ¶F 1 V¸ 8 Vb¹W b13, 14) -.{)*+,-.)8 X CT 9|/0Q )*+,-.)}1 CT ~88'qw-;xyz- COPD QR 2$3485& 67 08 !" !#$ %&'( )*+,-.)/01 2 345 678 ! !8 CT 9 EF 4 G41 DH 7F : I J 6 K 9 L 1 8) DH 9F &bc-de+C^<_>`a 7, 8, 21) MNO PMNOQR Cj\]<& !:S 23" 88n1)*+,-.);q !=)*+, !UVW -.)'>?@ !X#$IYZ$ 8) qqw-;xyz- COPD QR 7K9 L1 !S !$& Reid 92:;<=>?@AB>C D 7, 8, 21) DH 8F TJ 2$A&~8]Bqe&q )*+,-.)V:Q !" !'([\] +C^<_>`aC @b #$CDE " 25n <CA k! 33n1 5 K 8 L & b c - d 7 K 8 L 1 3. 7, 8, 21) 1 2eMN8& Legionella pneumophila FGfG4 \]fMN$gJh$&\] 2i)*+,-.)AB>C 2$A& 2K5 mm - Ht +t$@ I8V k!e"#$%lm b8JK& )wy¡>¢8VL£ 82n, 73n &o'pq(1 ¤M¥ )wy¡>¢UVW II {¦NO 22) § Ds*F q$¨& 67 08 j <CA 2. Chlamydophila pneumoniae Dr Chlamydia pneumoniaeF $JQ)s*t !+'( # yz©<CQ Rª«P¬j di#use alveolar damage (DAD) $& +,8Uuv%)*+,-.) Q1$& 5.2K11.2n w-;xyz- 3.4K6.5n J ®1R¯23) -MN8&&bcX+YºZ*[ »¼ Vol. 19 No. 2 2009. 15 °±6²³´7µ8¶´·9:¸´¹º;» 82 4) 5) 6) ) 10. 234567 $ CT (1£*+ £¤K FG6b (2¥*+ 3 ¦ §>-$¨ (2¥© ª«* ¬& !+ 4.5C® ! (2 ¥© V ¯*+ 7) 8) !"#$ 9) %#&!' () 10*+ ,-"./012345 67. 35 8.9: 24 8 (69;) ! 10) 7<=7$1 9;$%>-# ?&!'+ @ .A.BC.DE#1 .FG6 ,!- 8 8 (22;) 11) .HI.J 2 KLMN 7O- 1 $%>-+ 12) Vῌ ῍ ῐ ῏ ῎ 7P CT .K.QR1STU 1'+ VWX XY#Z [\ ]^_!` 7.abcUdefghi 13) "#$j$%k9+ ,-l7. CT BC /0m ?1n_oF p/0b,_! `qrhsK1t'+ 14) ῒ ῑ 1) uvLXwuvLxy8mGz{6z |}~w 2007. } 7qGz{6 z p. 2ῌ35, uvLXw ! 2) "# 1997. 7.qroi$ CT . Kh'.% X&Xw 57: 258ῌ264. 3) Fine, M. J., M. A. Smith, C. A. Carson, et al. 1996. Prognosis and outcomes of patients with community-acquired pneumonia. A meta-analysis. 16 p.¼<X Vol. 19 No. 2 2009. 15) 16) JAMA 275: 134ῌ141. Hasley, P. B., M. N. Albaum, Y. H. Li, et al. 1996. Do pulmonary radiographic findings at presentation predict mortality in patients with community-acquired pneumonia? Arch. Intern. Med. 156: 2206ῌ2212. Rello, J., R. Rodriguez, P. Jubert, et al. 1996. Severe community-acquired pneuimonia in the elderly: Epidemiology and prognosis. Clin. Infect. Dis. 23: 723ῌ728. Niederman, M. S., L. A. Mandell, A. Anzueto, et al. 2001. Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am. J. Respir. Crit. Care Med. 163: 1730ῌ1754. Reittner, P., S. Ward, L. Heyneman, et al. 2003. Pneumonia: High-resolution CT findings in 114 patients. Eur. Radiol. 13: 515ῌ521. Nambu, A., A. Saito, T. Araki, et al. 2005. Chlamydia pneumonia: Comparison with findings of Mycoplasma pneumoniae and Streptococcus pneumonia and thin-section CT. Radiology 238: 979ῌ986. Miller, W. S. 1947. The lung. Springfield, III: Thomas. p. 162ῌ204. Webb, W. R.. 2006. Thin-section CT of the secondary pulmonary lobule: Anatomy and the image. The 2004 Fleischner lecture. Radiology 239: 322ῌ338. Reid, L., G. Simon. 1958. The peripheral pattern in the normal bronchogram and its relation to peripheral pulmonary anatomy. Thorax 13: 103ῌ109. Reid, L. 1958. The secondary pulmonary lobule in the adult human lung, with special reference to its appearance in bronchograms. Thorax 13: 110ῌ115. Saito, A., S. Kohno, T. Matsushima, et al. 2006. Prospective multicenter study of the causative organisms of community-acquired pneumonia in adults in Japan. J. Infect. Chemother. 12: 63ῌ 69. Ishida, T., T. Hashimoto, M. Arita, et al. 2004. A 3-year prospective study of aurinary antigendetection test for Streptococcus pneumoniae in community-acquired pneumonia: Utility and clinical impact on the reported etiology. J. Infect. chemother. 10: 359ῌ363. '() 1990. g,K*K 7 uv 9: 263ῌ267. ': ( + A 1998. , - ../* #¡\!t0¢.g, K*K 7. 1 uvLXw 36: 444ῌ447. CT 17) 18) 19) 20) Low, I. E., S. M. Zimkus. 1973. Reduced nicotinamide adenine dinucleotide oxidase activity and H2O2 formation of Mycoplasma pneumoniae. J. Bacteriol. 116: 346ῌ354. Chu, H. W., S. Jeyaseelan, J. G. Rino, et al. 2005. TLR2 signaling is critical for Mycoplasma pneumoniae-induced airway mucin expression. J. Immunol. 174: 5713ῌ5719. Shimizu, T., Y. Kida, K. Kuwano, 2007. Triacylated lipoproteins derived from Mycoplasma pneumoniae activate nuclear factor-kappaB through toll-like receptors 1 and 2. Immunology 121: 473ῌ483. Wu, Q., R. J. Martin, S. Lafasto, et al. 2008. Toll-like receptor 2 down-regulation in estab- 21) 22) 23) 83 lished mouse allergic lungs contributes to decreased mycoplasma clearance. Am. J. Respir. Crit. Care Med. 177: 720ῌ729. Tanaka, N., T. Matsumoto, T. Kuramitsu, et al. 1996. High resolution CT findings in community-acquired pneumonia. J. Comput. Assist. Tomogr. 20: 600ῌ608. Lee, I., T. S. Kim, H. K. Yoon. 2006. Mycoplasma pneumoniae pneumonia: CT features in 16 patients. Eur. Radiol. 16: 719ῌ725. Sakai, F., H. Tokuda, H. Goto, et al. 2007. Computed tomographic features of Legionella pneumophila pneumonia in 38 cases. J. Comput. Assist. Tomogr. 31: 125ῌ131. Understanding of Community-acquired Pneumonia on the basis of chest computed tomography imaging Hirotsugu Ohkubo, Yuki Togashi, Yuta Kono, Yasuhiro Setoguchi First Department of Internal Medicine, Tokyo Medical University, 6ῌ7ῌ1 Nishi-shinjuku, Shinjuku-ku, Tokyo 160ῌ0023, Japan Computed tomographic (CT) scans are now working in many general hospitals in Japan. Most of the Japanese clinicians can use CT scans as one of the useful tool of the examination of community-acquired pneumonia. Chest CT imaging plays an important role in the accurate interpretation of pulmonary anatomy and pathology. Mycoplasma pneumoniae pneumonia and Chlamydophila pneumoniae pneumonia demonstrate centrilobular or acinar shadows, and thickening of bronchivascular bundles on CT imaging. Characteristic findings of Legionella pneumophila pneumonia on CT are sharply demarcated peribronchovascular foci of consolidation intermingled with ground glass opacity. It is possible to estimate the pathogenic bacteria, if there are characteristic features on CT imaging on the basis of clinical information. Vol. 19 No. 2 2009. 17
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