Performance Leadership Team A d o l e s c e n t H e a lt h C e n t e r Michael Fisher President and Chief Executive Officer o f G r e at e r C i n c i n n at i Janet Ach President Frank Biro, MD Director, Division of Adolescent Medicine Ca r e F o u n d a t i o n Michael Lee, DDS President Stephen Wilson, DMD, MA, PhD Director, Division of Pediatric Dentistry C o n va l e s c e n t H o s p i ta l f o r Ch i l d r e n Pamela Terp Chair Phillip C. Long President J a c k Ru b i n s t e i n F o u n d at i o n f o r D e v e l o p m e n ta l D i s o r d e r s JoAnn Hagopian President Mitchell Cohen, MD Vice Chair of Pediatrics for Clinical Affairs Brian D. Coley, MD Radiologist-in-Chief and Director, Department of Radiology Dwight E. Ellingwood Senior Vice President, Planning and Business Development Michael K. Farrell, MD Chief-of-Staff Jane Garvey Vice President, Marketing and Communications Tracy Glauser, MD Associate Director, Clinical Translational Outcomes and Health Services Research, Cincinnati Children’s Research Foundation Scott J. Hamlin Executive Vice President and Chief Operating Officer Cheryl Hoying, PhD, RN Senior Vice President, Department of Patient Services Production credits Produced by the Department of Marketing and Communications Cincinnati Children’s Hospital Medical Center Jane Garvey, Vice President William M. Kent Senior Vice President, Infrastructure and Operations Charles Dean Kurth, MD Anesthesiologist-in-Chief and Director, Department of Anesthesia Frederick Ryckman, MD Senior Vice President, Medical Operations James A. Saporito Senior Vice President, Development Elizabeth A. Stautberg, Esq. General Counsel and Senior Vice President, Legal and Public Affairs Arnold W. Strauss, MD Physician-in-Chief; Chair, Department of Pediatrics, University of Cincinnati; and Director, Cincinnati Children’s Research Foundation Jeffrey Whitsett, MD Interim Associate Director, Basic Sciences, Cincinnati Children’s Research Foundation 3 3 3 3 B U R N E T AV E N U E , C I N C I N N AT I , O H I O 4 5 2 2 9 - 3 0 2 6 WWW. C I N C I N N AT I C H I L D R E N S . ORG 2 Message from our CEO and Chairman 4 Message from our Finance Leaders 6 Casting Light on a Rare Lung Disease Tribute: William Kuenneth Schubert, MD 16 Deciphering the Mysteries of Eosinophilic Disorders 22 Revealing the Power of a Life-Altering Drug 28 Guiding Asthma Patients to a Better Quality of Life Elli Edwards, Jennifer Sennett, Shannon Studebaker 32 The Convalescent Hospital for Children: Evolving, Educating, Empowering Ph o t o g r a p h y 34 Donor Recognition Ryan Kurtz; additional photos from the Cincinnati Children’s archive 77 Financial Report 80 Our Leaders Beatrice Katz Uma R. Kotagal, MD Senior Vice President, Quality and Transformation T A BLE OF CONTENTS 14 Writer/project director 2 0 1 2 A N N UA L R E P O RT David Schonfeld, MD Director, Division of Developmental and Behavioral Pediatrics Elisabeth Baldock, PhD Senior Vice President, Human Resources Marianne F. James Senior Vice President, Information Services, and Chief Information Officer C I N C I N N AT I C H I L D R E N ’ S H O S P I TA L M E D I C A L C E N T E R Ch i l d r e n ’ s D e n t a l Richard G. Azizkhan, MD Surgeon-in-Chief I L LU M I N AT I N G D I S C O V E R I E S Affiliates Design Real Art Donor recognition Printing Wendling Printing Company Cincinnati Children’s Hospital Medical Center is a teaching affiliate of the University of Cincinnati College of Medicine. The medical center is accredited by The Joint Commission; CARF, The Rehabilitation Commission; and the Association ILLUMINATING for the Accreditation of Human Research Protection Programs, Inc. We have been awarded Magnet recognition from the American Nurses Credentialing Center for quality patient care and nursing excellence. Our pediatric residency training program is approved by the Accreditation Council for Graduate Medical Education. DISCOVERIES appropriately qualified persons of diverse backgrounds. The medical BRIDGING RESEARCH, CARE AND COMMUNITY ancestry, national origin, age, disability, political affiliation or Cincinnati Children’s affirmatively seeks to attract to its staff center does not discriminate against any employee or applicant based on race, color, creed, religion, sex, sexual orientation, status as a disabled veteran or veteran of the Vietnam conflict. Cincinnati Children’s ranked third among all pediatric hospitals in the 2012 U.S. News & World Report survey of best children’s hospitals. ©2012 Cincinnati Children’s Hospital Medical Center 2012 ANNUAL REPORT COVER Jordan Scott, 9, has eosinophilic esophagitis and is a patient of the Cincinnati Center for Eosinophilic Disorders. F r o m l e f t t o r i gh t : Cincinnati Children’s first home was a rented house. Tw o William Cooper Procter gave $2.5 million to build and endow the Children’s Hospital Research Foundation. Th r e e Cincinnati Children’s was the first pediatric hospital to have a building dedicated to research. It opened in 1931. F o u r Josef Warkany, MD, arrived January 1, 1932, for a one-year fellowship. He spent his entire career at Cincinnati Children’s, becoming a pioneer in the study of birth defects. F i v e Chemist and inventor Leland Clark, PhD, developed the first functional heart-lung machine. Using Clark’s machine, the cardiology team at Cincinnati Children’s performed the first open heart surgery. 1883 1924 Incorporation papers for the Protestant Episcopal Hospital for children are signed November 16, 1883. The hospital opens in a rented three-bedroom house in March 1884. 1887 Hospital moves to its second home. The new hospital opens with 20 beds on two wards and room for two additional wards. 1921 William Cooper Procter, president of Procter & Gamble, is elected president of the hospital’s board of trustees, a position he held until his death in 1934. The hospital’s name is changed to The Children’s Hospital. Procter forms a dynamic partnership with the newly appointed B.K. Rachford Chair of Pediatrics of the University of Cincinnati College of Medicine, Albert Graeme Mitchell, MD. Working together over the next decade, Procter and Dr. Mitchell increase the size of The Children’s Hospital, enlarge the staff and expand the hospital’s mission to include medical education and research. 1926 The Children’s Hospital establishes an academic affiliation with the College of Medicine as the Department of Pediatrics. Dr. Mitchell is the first to be both chair of Pediatrics and physician-in-chief of The Children’s Hospital, a tradition that continues today. On December 6, the hospital moves into its new, 200-bed facility adjacent to the college, built on land Procter selected and purchased. 1928 Dr. Mitchell advocates for research at The Children’s Hospital. In December, Procter announces a gift of $2.5 million to build and endow The Children’s Hospital Research Foundation. 1931 The Children’s Hospital Research Foundation opens. The Children’s Hospital is the nation’s first pediatric hospital with a building dedicated to research. 1932 Josef Warkany, MD, arrives from Vienna for a one-year research fellowship. He spends his entire and highly productive career at Cincinnati Children’s. Known as the father of teratology, Dr. Warkany did pioneering research on nutritional and environmental factors that cause birth defects. F r o m l e f t t o r i gh t : Albert Sabin, MD, spent 30 years at Cincinnati Children’s. The Sabin oral polio vaccine was adopted by the World Health Organization in its campaign to eradicate polio worldwide. Tw o In 1988, Jeffrey Whitsett, MD, announced his research team had identified and cloned two proteins essential for human surfactant. Today surfactant replacement therapy is routinely used to save the lives of premature infants with respiratory distress syndrome. Th r e e Richard Ward, PhD, began studying rotavirus in 1981. His research, in partnership with David Bernstein, MD, led to development of a safe, effective vaccine to prevent rotavirus infection. The vaccine is now used around the world. F o u r Cincinnati Children’s broke ground for a new clinical sciences building in 2012. The 425,000 square foot building will provide space to consolidate and expand patient-oriented research activities. 1957 1939 1951 Albert Sabin, MD, joins The Children’s Hospital Research Foundation. His research proved that poliovirus enters the body through the digestive tract. He also found polioresistant antibodies in some children, suggesting they had been infected by a weakened strain that produced immunity. Based on these observations, he developed the world’s first attenuated (weakened) live-virus vaccine–the Sabin oral polio vaccine. Chemist Leland Clark, PhD, then based at Antioch College, brings his bubble defoam oxygenator heart-lung bypass machine to Cincinnati Children’s. Cardiologist Samuel Kaplan, MD, and surgeon James Helmsworth, MD, work with Clark to perfect it. A prolific inventor, Dr. Clark also developed the Clark oxygen electrode, which is used worldwide in medical and industrial applications. 1942 Ashley Weech, MD, is named chairman of Pediatrics and director of The Children’s Hospital Research Foundation. After WWII ends, he expands the faculty, adding directors of new subspecialty divisions as the field of pediatrics becomes increasingly specialized. Building a Research Legacy 1952 Using the heart-lung machine, the Cincinnati Children’s team performs the earliest open heart surgery, reported in the Journal of the American Medical Association (October 4, 1952). 1956–2012 on back cover The World Health Organization chooses Sabin’s vaccine for worldwide testing. Millions of doses are given in Russia, Holland, Mexico, Chile, Sweden and Japan. 1960 The first US test of the Sabin oral polio vaccine begins in Cincinnati on April 24, 1960, known as Sabin Sunday. More than 20,000 children received the vaccine. 1976 1963 Edward Pratt, MD, is named chairman of Pediatrics and director of The Children’s Hospital Research Foundation. The Clinical Research Center is established, with William K. Schubert, MD, as its founding director. 1968 The Institute for Developmental Research (IDR) opens. The building doubled office and laboratory space, and allowed a large influx of research scientists. 1 8 8 3 – 1 9 5 5 o n FRONT c o v e r Lonnie Wright, MPH, PhD, is appointed the hospital’s first full-time president and CEO. 1979 Dr. Schubert succeeds Dr. Pratt as chairman of the Department of Pediatrics and director of the Children’s Hospital Research Foundation. 1983 Dr. Schubert is appointed president and CEO. 2003 1988 1993 Neonatologist Jeffrey Whitsett, MD, announces his team has identified and cloned two proteins essential to human surfactant. The discovery made it possible to produce synthetic human surfactant for treating premature infants with respiratory distress syndrome. Thomas Boat, MD, succeeds Dr. Schubert as chairman of Pediatrics and director of the Children’s Hospital Research Foundation. 1996 2004 James M. Anderson succeeds Dr. Schubert as president and CEO. The rotavirus vaccine developed by Richard Ward, PhD, and David Bernstein, MD, is licensed in Mexico. Today the vaccine is used in over 100 countries, and the World Health Organization has recommended that rotavirus vaccine be included in all national immunization programs. 1998 1991 First new research building since 1968 opens, providing space for 19 research programs in 240 new labs. Research is increasingly focused on molecular genetics. Demolition of the 1926 hospital begins to make way for a new research building. Construction begins in 2004. Cincinnati Children’s begins an ambitious building expansion. Over the next four years, the Sabin Education Center, a research wing, a garage, and a new hospital building (now called Location A) are added to the Burnet Campus. Improving Child Health 2007 Location S opens on the site of the 1926 hospital. The building adds 415,000 square feet for research. Reflecting the depth and breadth of its research program, Cincinnati Children’s is now second in the nation in NIH grants for pediatric research. Arnold Strauss, MD, succeeds Dr. Boat as chair of Pediatrics and director of the Cincinnati Children’s Research Foundation. 2010 Michael Fisher succeeds James Anderson as president and CEO. 2012 Cincinnati Children’s breaks ground for a 425,000 square foot clinical sciences building that will provide space to consolidate and expand patient-oriented research. When the building opens in 2015, Cincinnati Children’s will have 1.4 million square feet for research. Performance Leadership Team A d o l e s c e n t H e a lt h C e n t e r Michael Fisher President and Chief Executive Officer o f G r e at e r C i n c i n n at i Janet Ach President Frank Biro, MD Director, Division of Adolescent Medicine Ca r e F o u n d a t i o n Michael Lee, DDS President Stephen Wilson, DMD, MA, PhD Director, Division of Pediatric Dentistry C o n va l e s c e n t H o s p i ta l f o r Ch i l d r e n Pamela Terp Chair Phillip C. Long President J a c k Ru b i n s t e i n F o u n d at i o n f o r D e v e l o p m e n ta l D i s o r d e r s JoAnn Hagopian President Mitchell Cohen, MD Vice Chair of Pediatrics for Clinical Affairs Brian D. Coley, MD Radiologist-in-Chief and Director, Department of Radiology Dwight E. Ellingwood Senior Vice President, Planning and Business Development Michael K. Farrell, MD Chief-of-Staff Jane Garvey Vice President, Marketing and Communications Tracy Glauser, MD Associate Director, Clinical Translational Outcomes and Health Services Research, Cincinnati Children’s Research Foundation Scott J. Hamlin Executive Vice President and Chief Operating Officer Cheryl Hoying, PhD, RN Senior Vice President, Department of Patient Services Production credits Produced by the Department of Marketing and Communications Cincinnati Children’s Hospital Medical Center Jane Garvey, Vice President William M. Kent Senior Vice President, Infrastructure and Operations Charles Dean Kurth, MD Anesthesiologist-in-Chief and Director, Department of Anesthesia Frederick Ryckman, MD Senior Vice President, Medical Operations James A. Saporito Senior Vice President, Development Elizabeth A. Stautberg, Esq. General Counsel and Senior Vice President, Legal and Public Affairs Arnold W. Strauss, MD Physician-in-Chief; Chair, Department of Pediatrics, University of Cincinnati; and Director, Cincinnati Children’s Research Foundation Jeffrey Whitsett, MD Interim Associate Director, Basic Sciences, Cincinnati Children’s Research Foundation 3 3 3 3 B U R N E T AV E N U E , C I N C I N N AT I , O H I O 4 5 2 2 9 - 3 0 2 6 WWW. C I N C I N N AT I C H I L D R E N S . ORG 2 Message from our CEO and Chairman 4 Message from our Finance Leaders 6 Casting Light on a Rare Lung Disease Tribute: William Kuenneth Schubert, MD 16 Deciphering the Mysteries of Eosinophilic Disorders 22 Revealing the Power of a Life-Altering Drug 28 Guiding Asthma Patients to a Better Quality of Life Elli Edwards, Jennifer Sennett, Shannon Studebaker 32 The Convalescent Hospital for Children: Evolving, Educating, Empowering Ph o t o g r a p h y 34 Donor Recognition Ryan Kurtz; additional photos from the Cincinnati Children’s archive 77 Financial Report 80 Our Leaders Beatrice Katz Uma R. Kotagal, MD Senior Vice President, Quality and Transformation T A BLE OF CONTENTS 14 Writer/project director 2 0 1 2 A N N UA L R E P O RT David Schonfeld, MD Director, Division of Developmental and Behavioral Pediatrics Elisabeth Baldock, PhD Senior Vice President, Human Resources Marianne F. James Senior Vice President, Information Services, and Chief Information Officer C I N C I N N AT I C H I L D R E N ’ S H O S P I TA L M E D I C A L C E N T E R Ch i l d r e n ’ s D e n t a l Richard G. Azizkhan, MD Surgeon-in-Chief I L LU M I N AT I N G D I S C O V E R I E S Affiliates Design Real Art Donor recognition Printing Wendling Printing Company Cincinnati Children’s Hospital Medical Center is a teaching affiliate of the University of Cincinnati College of Medicine. The medical center is accredited by The Joint Commission; CARF, The Rehabilitation Commission; and the Association ILLUMINATING for the Accreditation of Human Research Protection Programs, Inc. We have been awarded Magnet recognition from the American Nurses Credentialing Center for quality patient care and nursing excellence. Our pediatric residency training program is approved by the Accreditation Council for Graduate Medical Education. DISCOVERIES appropriately qualified persons of diverse backgrounds. The medical BRIDGING RESEARCH, CARE AND COMMUNITY ancestry, national origin, age, disability, political affiliation or Cincinnati Children’s affirmatively seeks to attract to its staff center does not discriminate against any employee or applicant based on race, color, creed, religion, sex, sexual orientation, status as a disabled veteran or veteran of the Vietnam conflict. Cincinnati Children’s ranked third among all pediatric hospitals in the 2012 U.S. News & World Report survey of best children’s hospitals. ©2012 Cincinnati Children’s Hospital Medical Center 2012 ANNUAL REPORT COVER Jordan Scott, 9, has eosinophilic esophagitis and is a patient of the Cincinnati Center for Eosinophilic Disorders. ILLUMINATING DISCOVERIES BRIDGING RESEARCH, CARE AND COMMUNITY 2012 ANNUAL REPORT Dear Friends, In our annual reports, we try to capture in words and pictures the vision that drives Cincinnati Children’s and our many partners: the passion to improve child health; the commitment to discovery, innovation and improvement. This year, we focus on one of the most powerful ways we improve child health: through patient-oriented research. Research at Cincinnati Children’s spans the entire arc from basic science through application and outcomes research, from bench to bedside and into the community. Every day, we strive to cast new light on complex diseases– and most importantly, to translate discoveries into new treatments that make a difference for patients. In this report, you’ll read about three programs that excel in bridging research, discovery and care. You’ll learn about two girls from Kuwait who are in Cincinnati for lifesaving care of a rare lung disease, and about pioneering research that offers them hope of a cure. You’ll learn how researchers and parents formed a productive partnership that resulted in rapid advances in the fight against eosinophilic gastrointestinal disorders. And you’ll learn about leading-edge clinical trials of the first medicine that can shrink brain, kidney and lung tumors in patients with tuberous sclerosis. TOP TO BOTTOM Michael Fisher, Thomas Cody These inspiring achievements are changing the outcome for our patients today–and illuminating the way to a healthier future for children everywhere. We remember 2012 as a year of exciting beginnings but also sad losses. In February, we lost one of our greatest leaders –William Kuenneth Schubert. As leaders of Cincinnati Children’s, we know that a great and enduring institution must excel in the present and continually look to the future. The strength of Cincinnati Children’s today is a tribute to the wisdom, vision and actions of leaders, staff and supporters throughout our 129-year history. It’s the responsibility of this generation to plan for the well-being of the children and families who will need us 129 years from now. In a career spanning nearly 50 years at Cincinnati Children’s, Dr. Schubert was a distinguished pediatrician, teacher, child advocate, researcher and leader, as well as a generous supporter. He made immeasurable contributions to our institution, our community and to the families we are privileged to serve. We continue to build on the legacy he left. We were proud, therefore, to announce plans in April 2012 to build a new clinical sciences building. When it opens in 2015, it will provide space to consolidate and expand patient-oriented research activities. It will allow us to strengthen the critical link between research and patient outcomes. It will help us do more, learn more and improve the lives of more children and families. Sincerely, Michael Fisher President and CEO This investment is a mark of our unwavering commitment to improve child health. We move forward knowing that achieving the best results for children will take support from many partners and donors who share the passion to make a difference. Together, we will advance knowledge, improve care and change lives. Thomas G. Cody Chairman 3 Dear Friends, In many ways, fiscal 2012 represents the culmination of a long, steady financial journey and first steps toward a new way forward. This approach demands that we work with community partners and stakeholders in ways we are only beginning to harness and adequately support. For the past seven years, Cincinnati Children’s has been exceptionally focused on improving and expanding programs, facilities, partnerships and infrastructure to meet two complementary but different goals: to better serve our community’s children and to be the global leader in providing complex care for patients from all geographies. The responsibilities and stewardship associated with these roles required financial excellence in two very different and demanding business models. Conversely, our commitment to being the global leader for complex pediatric care requires a business model based on unique clinical capabilities coupled with leading-edge scientific discovery. To succeed, we must differentiate our services from the national and global market and establish Cincinnati Children’s as the destination of choice for highly specialized care. As the community’s leader in promoting and improving the health of our region’s children and teens, Cincinnati Children’s recognizes that healthcare must shift from a system focused on delivering medical services to a new model that empowers children and families to take charge of their own health. This year’s annual report features a story about our efforts to help families whose children have asthma manage the disease more effectively and reduce their need for hospital care. This shift in philosophy requires a new business model–one focused on strengthening the patient’s self-management skills and on ensuring that when care is required, families have access to the right care, at the right time, in the right setting, which may well be outside our hospital walls. T O P T O B O T T O M Scott Hamlin, Robert D. H. Anning, Felicia Williams In the end, revenue growth stimulated by increased demand for services, coupled with successful per-patient-treated cost reductions led to net operating revenues of over $128 million–a strong improvement over last year. This, in turn, will allow us to accelerate our investment in new scientific discovery, new program offerings, expanded community partnerships and in the infrastructure and family support our patients require. Sincerely, The improved financial results of fiscal 2012 (see Financial Report, pages 77-79) hint at the powerful potential locked within our journey to become far better at both roles– community leader and global leader. The statistical highlights in our financial report show that we were able to touch the lives of a record number of patients and families in virtually every setting in which we provide care. Increased demand for our services and expertise led to operating revenues that grew nearly 9 percent to $1.85 billion this year. And equally satisfying, our per patient encounter cost of providing clinical care actually decreased about 4 percent on an inflation-adjusted basis, as a result of an institution-wide effort to decrease costs and improve efficiency and productivity. A nation hungry for demonstrably better value from its healthcare system is demanding that we take this success much further in the coming years–and we are committed to doing that. S c o tt H a m l i n Executive Vice President and COO Robert D.H. Anning Chair, Finance Committee F e l i c i a W i l l i a ms Chair, Audit and Compliance Committee 5 Nawaf and Fatemah Al-Shammari searched the world for a doctor who could help their daughter. By the time the search led them to Cincinnati Children’s, hope was running out for 3-year-old Nourah. Within a month Nourah was in the ICU, unconscious, on a respirator. While she was in the ICU, her doctors performed the bronchoscopy. The results were surprising: They didn’t find infection or inflammation, but sediments– evidence of a very rare lung disease. She was desperately ill from a mysterious lung disease. Nourah Al-Shammari came to Cincinnati Children’s for lifesaving treatment for a rare lung disease. Now a cure is on the horizon, thanks to pioneering research. Casting Light on a Rare Lung Disease At Cincinnati Children’s, the Al-Shammari family found a doctor with expertise in the complex treatment Nourah needs. And more, they found a research team with expertise in lung biology. Her parents and medical team began searching for help outside Kuwait. It’s a rare combination: outstanding patient care sideby-side with outstanding research; collaboration among the doctors who treat sick children and the researchers studying what underlies disease; basic science grounded in clinical challenges. “I sent her records to many hospitals,” her father recalls, “but no one would accept her case.” Nourah’s doctor sought advice from pulmonary experts worldwide through an online discussion group on the internet. That’s how he found Robert Wood, MD, PhD, director of bronchoscopy at Cincinnati Children’s. For Nourah, it’s a combination that made all the difference. The best available treatment saved her life. Innovative research offers hope for a complete cure. “I saw his inquiry and recommended whole lung lavage,” says Dr. Wood. “He asked if he could send his patient to me.” A M y st e r i o u s L u n g D i s e a s e Born in Kuwait in 2005, Nourah was an apparently healthy baby until she was 2½ years old. Then suddenly she became very sick with asthma and coughing. She grew lethargic. She turned blue. “W o o d ’ s L u n g L au n d r y ” Whole lung lavage (WLL) is a complicated procedure, used to treat pulmonary alveolar proteinosis (PAP). For decades the only thing known about this rare disease was that patients with PAP have too much surfactant in their lungs, making it difficult for them to get air in. What was making her so sick? A lung specialist wanted to do a bronchoscopy exam, but Nourah was too sick to risk giving her anesthesia for the procedure. Surfactant, a fatty substance produced by the lungs, reduces surface tension and keeps the lung’s tiny air sacs (alveoli) 7 excess surfactant. As a result, her family has remained in Cincinnati since 2008. Dr. Wood washes her lungs every 3 to 6 weeks. laboratory studies of an innovative genetic therapy that, in preliminary tests, cures it. Nourah and Bashayer will be in the first group of patients offered the new therapy when it is approved for testing in humans. Cousin Bashayer Arrives Nourah is alive today because of the expert care available at Cincinnati Children’s. But the story is far more complicated. Decades of Discovery Scientists at Cincinnati Children’s have been at the leading edge of research on surfactant-related diseases since the 1980s, when a team led by neonatologist Jeffrey Whitsett, MD, did groundbreaking work on respiratory distress syndrome in premature infants. Back home in Kuwait, her cousin, Bashayer, also suffered from pulmonary alveolar proteinosis. Not long after Nourah arrived in Cincinnati, Bashayer’s family moved here, too. Nourah undergoes whole lung lavage every three to six weeks. In the OR, Dr. Robert Wood inserts a breathing tube into her lungs. He keeps one lung mechanically ventilated and dry while he fills the other with saline, vibrates her chest wall to mix the surfactant into the saline, and then drains her lung. He repeats this several times. The process is repeated at a later time to clean the other lung. W h o l e L u n g L ava g e Dr. Wood now was treating first cousins–just 3 and 4 years old–with PAP. The lungs of premature babies are not able to produce enough surfactant. Respiratory distress due to insufficient surfactant is a killer in these tiny babies. Very unusual. For decades, PAP was believed to be an acquired disease, occasionally seen in children, but mostly in adults. Dr. Wood, one of the world’s experts, has 40 years of experience with the procedure in children. He agreed to see Nourah. open. Having either too little or too much surfactant is life-threatening. Without it, air sacs in the lung collapse when we exhale and struggle to expand with a new breath. This is what happens in premature babies who are born before their lungs have developed the capacity to produce surfactant. The US and Kuwaiti embassies worked together to get the family the necessary travel visas and arrange the 6,800 mile trip, accompanied by a doctor and nurse. Dr. Wood performed Nourah’s first lavage treatment just three days after she arrived in Cincinnati in November 2008. He washed her lungs with many liters of saline to remove the surfactant sediment. Within three weeks, she was well enough to leave the hospital. But if we have too much surfactant, as in PAP, it fills up space that should be filled with air. There’s only one treatment for PAP: washing the lungs to get rid of excess surfactant. “Lung laundering,” as Dr. Wood calls it. Though the treatment is effective, lavage is a temporary fix. Nourah’s lungs continue to become clogged with Not many hospitals have the ability to perform whole lung lavage on a child as young, tiny and fragile as Nourah. 8 Dr. Whitsett made an important breakthrough in the fight to save preemies. He identified and cloned two proteins essential to human surfactant. His research made it possible to produce a genetically engineered surfactant treatment for preemies. Surfactant replacement therapy is now routinely used in newborn ICUs–saving thousands of babies every year. Today, because of Nourah, Bashayer and a handful of other young patients, researchers at Cincinnati Children’s have identified a previously unknown hereditary type of PAP (hPAP). Working rapidly, a research team led by Bruce Trapnell, MD, developed a test to diagnose hPAP and is conducting Opp o r t u n i t i e s f o r D i s c o v e r y “You have to know enough basic science to be able to problem solve, and you have to understand the disease enough to know what you’re looking for. Cincinnati Children’s brings the two halves together– research and clinical care, tools and patients. The combination makes this one of the best places on the planet to do pulmonary research.” Bruce Trapnell, MD 9 Dr. Whitsett and his research team have continued to focus intensively on lung biology and surfactant-related diseases. In fact, their research in the 1990s helped explain the basic biology of PAP. “When this work began, no one knew how PAP developed,” says Dr. Trapnell. “In fact, there was a lot of misunderstanding.” People thought PAP was the result of the body producing too much surfactant. Piece by piece, a different picture emerged from laboratory research at Cincinnati Children’s. T h e B a s i c s o f PA P The work began when scientists at MIT turned to Dr. Whitsett for help. They were trying to understand the role of a newly identified protein, GM-CSF (granulocyte macrophage colony-stimulating factor). The protein appeared to promote the growth of macrophages. It was important to understand GM-CSF’s role, because macrophages in our white blood cells are a key part of the immune system. It turns out that PAP is not due to overproduction of surfactant but under-clearance of old, used surfactant. Research showed that GM-CSF is needed for macrophages to mature. If the cells don’t mature, they can’t do their job. In the lung, a key job is to get rid of used surfactant. If they don’t do this, the surfactant accumulates as sediment. Over time, the lungs fill up. Described as garbage collectors, macrophages travel through the body, looking for trash, such as worn out cells or toxins or bacteria. When they find something that shouldn’t be there, they surround it and digest it. As this insight became clear, a research team in Japan discovered that patients with PAP had an antibody against GM-CSF. By the early 2000s, the Japan and Cincinnati teams were working together. To learn more about the role of GM-CSF in this process, the scientists created a model in mice by knocking out the gene that makes the GM-CSF protein. They expected to find that the mice would not be able to make macrophages. Meticulous work at Cincinnati Children’s proved that the antibody was not merely present, but was actually causing the disease. That’s not what happened. The mice did produce macrophages, but oddly enough, the mice had a lot of surfactant in their lungs. Why? This finding defined PAP as an autoimmune disorder– a condition in which the body mistakenly attacks its own normal functioning. The researchers needed an expert in lung disease and surfactant. They turned to Dr. Whitsett, who recognized the mice had PAP. One output of the research was a diagnostic test for autoimmune PAP, making a bridge from the basic science lab to clinically relevant information. Today Cincinnati Children’s is one of just four centers worldwide that performs diagnostic testing for autoimmune PAP. Researchers at Cincinnati Children’s have been studying PAP ever since. 10 L e ft Jeffrey Whitsett, MD, conducted research in the 1980s that resulted in lifesaving surfactant replacement therapy for premature babies with respiratory distress syndrome. R i g h t Cincinnati Children’s investigators have continued to focus on surfactant-related diseases. The research team studying hPAP includes (l-r) Takuji Suzuki, MD, PhD, Brenna Carey, PhD, and Bruce Trapnell, MD. After a decade of work, we thought we had a pretty clear picture of the basic biology of PAP. Until we started seeing patients like Nourah and Bashayer. They reanalyzed the data and retrospectively found five other cases. Then Nourah and Bashayer arrived. By now there were enough cases to begin to define the natural history of this new condition. Going further, Dr. Trapnell developed a test to diagnose it, and he created a mouse model to study it in the lab. Because it turned out, they don’t have the antibody. H e r e d i ta ry PA P In 2007, Dr. Wood saw a 6-year-old girl from North Carolina who appeared to have PAP. But when Dr. Trapnell ran the diagnostic test on a blood sample, she did not have the antibody. When he measured her GM-CSF level, it was elevated. Molecular analysis identified a genetic defect in the macrophages. They can’t receive signals from GM-CSF. Since they don’t get the right message, they don’t clean up old surfactant. This was something new. The outcome is the same as in autoimmune PAP–too much surfactant in the lungs. But the disease pathway in hPAP is quite different. Over the years the research team had carefully maintained a database of patient information and blood samples. 11 “We know exactly where the target is,” says Dr. Trapnell. “By deepening our understanding of the basic biology, we can move toward therapy for these conditions, and we are likely to learn something more general about autoimmune and genetic diseases that can be applied to other, more common and complex conditions.” Parents, physicians and researchers all feel a sense of urgency, yet know the work must move forward step by step. It may take two years or more before all the preclinical work is completed and Cincinnati Children’s receives approval to begin human testing through a clinical trial. In the meantime, Nourah and Bashayer need regular lavage treatments. Is there a way they can have these treatments in Kuwait? L e ft Bashayer Al-Shammari, Nourah’s cousin, also has hPAP and undergoes regular whole lung lavage treatments at Cincinnati Children’s. R i g h t Nawaf Al-Shammari searched the world for a hospital that could help his daughter. Here he shares a quiet moment with Nourah. The long-term investment in lung research at Cincinnati Children’s has had an enormous impact. It bridged the gap between understanding basic biology and advancing care to improve the health of children. Dr. Wood has begun training Kuwaiti physicians to perform whole lung lavage in children as small as Nourah and Bashayer. As a first step, a Kuwaiti team visited Cincinnati Children’s in April to observe the procedure. A second trip for more training and hands-on experience is being planned, in preparation for the children to return to Kuwait. Basic science studies of surfactant led to a lifesaving treatment for respiratory distress syndrome in premature infants and to an ongoing interest in other surfactantrelated diseases, including PAP. Studying hPAP led to inventing a new procedure– pulmonary macrophage transplantation. “It’s not just a new treatment,” Dr. Trapnell says, “but a new class of treatment.” It opens the potential for new therapeutic approaches to other lung diseases. “They deserve to be home,” Dr. Wood says. “We have all the facilities here,” says Dr. Trapnell. “We’ll do the preclinical studies on safety and dosing. The Cincinnati Children’s Vector Lab will make the gene therapy vector and the Cell Manipulation Lab will prepare the cells for genetic therapy. We have all the necessary infrastructure.” N e x t S t e ps In a stunning advance, the basic research quickly led to a new type of therapy: pulmonary macrophage transplantation. In the lab, Dr. Trapnell’s team is able to correct the gene defect in mice macrophage cells and put the cells back into the lung. For Nourah and Bashayer, macrophage transplant offers the hope of a complete cure. “Because the GM-CSF levels are high, the macrophages we put into the lung proliferate,” he explains. “They go through the lung like Pac-Man, cleaning up surfactant. As they do this, they also get rid of excess GM-CSF, so the whole system comes back into equilibrium. It works so well, with just one treatment.” “We’re very happy that there’s a treatment,” says Fatemah Al-Shammari. “The girls can’t have lung lavage all their lives.” Why Study Rare Disease? PAP is a very rare disease–fortunately. One of the reasons to focus on rare diseases, Dr. Trapnell points out, is that they typically have a single cause that can be isolated and studied. The possibilities are speculative at this stage. But that’s a critical part of clinical science: linking clinical need, creative thinking and meticulous basic science to push the boundaries of knowledge, advance care and improve outcomes for patients. Autoimmune PAP is caused by an antibody that attacks only one protein in a single signaling pathway that macrophages require to function normally. Hereditary PAP is caused by a defect in another single component of the same signaling pathway. Cincinnati Children’s is proud to be at the forefront of such cutting-edge translational research. “Despite more than 20 years of research, not one lung disease has been successfully treated by gene therapy,” Dr. Trapnell points out. “This has the potential to be a major advance, the first successful lung gene therapy.” Cincinnati Children’s is uniquely positioned to move this research from the lab to patients. 12 13 W i l l i a m K u e n n e t h S c h u b e rt, M D July 12, 1926–February 25, 2012 The Cincinnati Children’s community mourns the passing of one of our greatest leaders, William Kuenneth Schubert, MD. director of the Clinical Research Center. In 1968, he established the Division of Gastroenterology. He also served as director of the pediatric residency program and chief-of-staff. He went on to be chairman of the Department of Pediatrics and director of the Cincinnati Children’s Research Foundation (1979-93) and president and CEO (1983-96). In a career spanning nearly 50 years at Cincinnati Children’s, Dr. Schubert dedicated his life to improving the health of children in our community and around the world. He made immeasurable contributions as a physician, child advocate, researcher, teacher, mentor and leader. And throughout his career, he gave generously to support the work of the institution he loved. Dr. Schubert was a compassionate physician, a brilliant diagnostician and an outstanding educator. He inspired generations of pediatricians and pediatric specialists. A Cincinnati native, Dr. Schubert attended the University of Cincinnati College of Medicine and completed his pediatric residency and fellowship training at Cincinnati Children’s. After seven years in private practice, he joined Cincinnati Children’s full-time in 1963, as the founding As a scientist, he did important research on liver disease, cholesterol, iron deficiency and Reye syndrome. He was a model of the clinician/researcher and encouraged physicians to pursue research careers. 14 As a child advocate, he was a spokesman for the position that no child should be turned away for lack of ability to pay. He worked tirelessly to pass the Hamilton County Health and Hospitalization tax levy and to consolidate pediatric care at Cincinnati Children’s, so that all kids could be treated equally. Aw a r d s HONORIN G D r . S c h u b e r t 1 9 8 9 William Cooper Procter Medallion (Cincinnati Children’s) 1 9 9 1 Daniel Drake Medal (University of Cincinnati College of Medicine) Under his leadership as chairman of Pediatrics and president and CEO, Cincinnati Children’s grew in clinical and research programs, recruited world-class talent and added new facilities. After he retired in 1996, Dr. Schubert continued to serve Cincinnati Children’s as a trustee, advisor and elder statesman. Distinguished Alumni Award (University of Cincinnati College of Medicine) 1992 Lifetime Hero Award (Cincinnati Business Courier) 2003 15 Murray Davidson Award (American Academy of Pediatrics, Section on Gastroenterology) 2003 2 0 0 4 Great Living Cincinnatian (Cincinnati USA Regional Chamber) 2 0 1 1 Business Hall of Fame (Jr. Achievement of Greater Cincinnati) “I remember telling my daughter Jori, when she was 14 years old, that she would not be able to eat food anymore,” recalls Ellyn Kodroff. “We sat at the kitchen table and sobbed as she took small sips of the vile-tasting formula, the only thing she could now have.” Jori, now 20, has an eosinophilic gastrointestinal disorder (EGID). She and her parents travel to Cincinnati Children’s from Chicago every three months so that she can be treated by the Cincinnati Center for Eosinophilic Disorders (CCED), led by Marc Rothenberg, MD, PhD. “Food is far more than just nourishment,” says Karen Philip, whose 12-year-old daughter, Grace, lives with an EGID. “It is an expression of our cultures and traditions. To have to view something so life- and soul-sustaining as a physical threat is daunting and, at times, exhausting.” Cincinnati Children’s has become the acknowledged leader in treating and studying eosinophilic disorders–newly recognized conditions in which the body’s immune system treats food as a harmful entity, a foreign invader. Ashton Burke learns about eosinophils during lab day, when patients with eosinophilic disorders get to meet researchers and have fun playing educational games modeled on real research activities. Deciphering the Mysteries D e c i p h e r i n g t h e M y st e r y A growing number of patients around the world face the challenge of living with and finding care for eosinophilic conditions. In the last decade, rates of many types of allergic diseases have skyrocketed. EGIDs now affect as many as one in 1,000 people. Though they are more common than inflammatory bowel disease and Crohn’s disease in children, EGIDs are not yet as widely known and are often misdiagnosed. In response to food, the body rapidly produces too many immune cells called eosinophils. The cells attack the pathway that food takes–esophagus, stomach, intestines and other organs. The eosinophils trigger chronic inflammation, pain and tissue damage. Individuals with EGID suffer from growth problems, stomach cramps, vomiting and diarrhea, and have trouble swallowing. During a recent orientation session for new patients at the CCED, several families talked about their difficulties of finding expert care: “My doctor had only seen one other patient with this condition,” said one. “You’re kind of a mystery,” said another. Some patients do well if they eliminate specific foods from their diet. Others are forced to stop eating all food and live on a liquid formula diet. The social, emotional and psychological effects can be staggering. Cincinnati Children’s is at the forefront of deciphering the mystery by bringing eosinophilic disorders to the attention of the medical community, as well as conducting research to understand these conditions and advance care. of Eosinophilic Disorders 17 research,” Dr. Putnam points out. “We’d only be able to look at the end of the chain–the cells under a microscope. We wouldn’t understand the processes.” T r a n sf o r m i n g t h e L a n d s c a p e Today the CCED is the world’s largest, most experienced clinical program for EGIDs, and the most productive research center. As with any new research endeavor, securing funding to pursue new ideas was vital. In addition to traditional federal research grant funding, the partnership and investment of private donors proved essential to advance the study and care of EGIDs. Lab day is open to patients and family members of all ages. Here a youngster gets his first look through a microscope. Marc Rothenberg, MD, PhD (at left), leads the Cincinnati Center for Eosinophilic Disorders. Here he meets with postdoctoral research fellow Ting Wen, PhD. L e ft Right The work began in 1999, with one child. At the time, there had been only a few reports in medical journals about patients who were thought to have reflux disease but did not respond to medication and had elevated eosinophils. Not much was known about the condition. Gastroenterologist Philip Putnam, MD, had a new patient in clinic. A biopsy sample of the child’s esophagus showed a lot of eosinophils. The Cincinnati Children’s team wanted to understand more about these mysterious conditions: How to recognize them. How to diagnose them. The underlying biological pathways. How to make life better for patients who suffer with them. He consulted with Dr. Rothenberg, director of the Division of Allergy/Immunology, who had done extensive basic research on eosinophils and their role in triggering allergic inflammation. That first patient at Cincinnati Children’s was soon followed by others. Dr. Putnam and Dr. Rothenberg started holding a combined clinic and meeting to talk about what they were seeing. Soon pathologist Margaret Collins, MD, joined their team. From that small beginning, a comprehensive patient care and research program grew. It was the first of its kind anywhere. Pa rt n e r i n g to A dva n c e R e s e a rc h Linking clinical and research expertise was critical to the program’s success. “We’d be flying blind without the basic 18 It has seen more than 1,000 children and adults since 1999. Families come from across the country and around the world seeking hope, healing and a better quality of life. The center has brought major research discoveries from the laboratory bench to the clinic–transforming the landscape for patients living with eosinophilic disorders. From hosting small fundraisers, to securing large-dollar support from nonprofits and foundations, to creating advocacy groups and testifying before Congress, the EGID community quickly established itself as an integral part of the CCED team. First, the CCED’s research in mouse models clarified the nature of these diseases. “Esophagitis used to be thought of as only acid reflux related,” says Dr. Rothenberg. “Our early studies provided a new paradigm, which subsequently has been accepted–that esophagitis could be an allergen-driven inflammatory process.” The Kodroff family launched the Campaign Urging Research for Eosinophilic Disease (CURED), a national advocacy organization dedicated to raising public awareness of EGIDs and funds for research to cure it. The Buckeye Foundation, which is managed by the Philip family, also supports the CCED’s work. “It was a smart investment,” says Karen. “Dr. Rothenberg had the infrastructure needed to make a meaningful impact on the disease. We knew our investment would yield results.” This discovery led to a now widely practiced treatment approach: anti-inflammatory drugs for eosinophilic esophagitis. The CCED conducted the first controlled clinical trial to test this approach. Today, two anti-inflammatory drugs are routinely used to control symptoms, and others are under development. These two groups have become transformational partners, donating more than $4 million to advance the study and care of EGIDs at Cincinnati Children’s. In another important contribution, the CCED advanced understanding of the genetics of EGIDs. “Witnessing their huge commitment is a tremendous inspiration for our team,” says Dr. Rothenberg. “Their partnership allowed us to pursue new ideas, often less conventional and more far-reaching than would be acceptable to typical funding agencies.” The CCED’s patient data, along with information compiled from its web-based patient registry, revealed that the disease occurs in families, suggesting that genetics has a role. 19 L e ft Jori Kodroff ’s family established the Campaign Urging Research for Eosinophilic Disease (CURED). Their partnership has provided critical support for research at Cincinnati Children’s. R i g h t Philip Putnam, MD, talks to 4-year-old Ellie Plummer before he performs an endoscopy procedure to test for eosinophils in her esophagus. Ellie was diagnosed with eosinophilic esophagitis when she was a baby. At 2½ she was put on the elemental diet. She stopped eating food and got all her nutrition from an amino acid formula. After three months, the eosinophils cleared out. Then Dr. Putnam began testing one food at a time to see what foods are safe for her. Today, Ellie can eat six foods, including apples, potatoes and grapes. In fact, as EGIDs are better understood, many adults– including the parents and relatives of some of our pediatric patients–are finally being diagnosed after a lifetime of struggling with an unrecognized condition. Dr. Rothenberg’s team also has developed a molecularbased diagnostic test for the disease. The test is currently being commercialized so that it can be available to patients everywhere. the clinical research enterprise necessary for truly meaningful translation of our findings to patients.” The CCED team has done pioneering research to decipher the genetic underpinnings of eosinophilic disorders. Dr. Rothenberg’s lab identified and defined the role of several genes and proteins involved. Thanks to these and other achievements, doctors are better able to reduce patients’ eosinophil levels and control the disease. Jori is now able to eat a few foods. Her college accommodates her very restricted diet by making her individualized meals with foods that are safe for her. These discoveries are fueling research for another promising treatment approach: antibodies against the proteins IL-5 and IL-13. Dr. Rothenberg led the first trials of anti-IL-5 and anti-IL-13. Several companies are now pursuing these approaches. Moving to the Next Level “The partnership of philanthropists helped us bring three major findings from the bench to patients,” says Dr. Rothenberg. “Their investment helped us build 20 Dr. Rothenberg is convinced that “modern genetic approaches give us the technical capacity to begin to understand why people develop the disease–and that will help us develop better diagnostic tests and treatments, and ultimately find the cure.” But more needs to be done to improve outcomes for those who live with EGID. “We’re making groundbreaking discoveries, but we still understand too little,” Dr. Rothenberg says. “A recent study by our group, showed that children with EGID have the lowest quality of life compared with a wide number of other common pediatric chronic diseases. It’s humbling to see the degree of patient suffering despite all that we’re doing. We need to bring this whole field to a higher level– and we’re well positioned to do that.” The patients and philanthropists who have run this race with him look forward to the day when they will cross the finish line together. “I believe Dr. Rothenberg will find a cure,” Ellyn Kodroff says. “Then Jori and all the others suffering will have the opportunity to eat and enjoy life again.” 21 Alyssa Loftus was a baby when she was diagnosed with a rare disease. Little was known about it, and there were very few specialized clinics in the country to serve patients with it. Since there was no clinic for her in Cincinnati, Alyssa’s parents traveled over 600 miles to take her to the nearest specialist–and he was about to retire. Every patient is affected differently. In some, symptoms are mild. In others, they’re severe. Though the TS tumors are not cancerous, they can be devastating and life-threatening. Tumors in the brain can cause seizures, autism and profound developmental delay. Tumors can destroy kidney and lung function. Concerned, they reached out to David Franz, MD, a young neurologist who had trained at Cincinnati Children’s and was joining the staff. Would he start a clinic for patients with tuberous sclerosis (TS)? From the beginning, the Cincinnati Children’s clinic set out to offer a new level of care. He said yes, and the institution supported the effort. Patients once were isolated, and care was fragmented. At Cincinnati Children’s, care would be coordinated. Patients would find lifelong care for all aspects of the disease. That was 1992. Today that clinic is the largest, most comprehensive TS clinic in the world. It is transforming care for children and adults with tuberous sclerosis. David Franz, MD, launched a clinic for patients with tuberous sclerosis (TS) in 1992. Today the TS program at Cincinnati Children’s is the world’s largest and is recognized for clinical excellence and leadership in clinical research. “All the specialties were there, in one clinic,” says Alyssa’s father. “The multidisciplinary approach was a huge benefit.” “It was a huge leap of faith on the part of Cincinnati Children’s,” says Alyssa’s father, Douglas Loftus. “The whole team’s commitment to creating a better future for kids with TS is just extraordinary.” In its first 10 years, the program gained recognition for clinical excellence. In its second decade, it became a powerhouse for clinical research. Alyssa, now 21, “has gotten the best care available,” her father says, “and it was right here in our backyard.” Revealing the Power The Cincinnati Children’s team has led a series of highly successful trials of the first drug that can alter the course of the disease. These studies resulted in rapid FDA approval of the medicine’s use for brain and kidney complications of tuberous sclerosis. Finding Hope Tuberous sclerosis is a genetic disease that can cause tumors to grow throughout the body–in vital organs, on the skin and in the eye. The future is no longer hopeless for patients with TS. o f a L i f e - A lt e r i n g D ru g 23 L e ft When Alyssa Loftus was a baby, her family traveled hundreds of miles to the nearest tuberous sclerosis specialist. Her parents asked Dr. Franz to start a TS program at Cincinnati Children’s. R i g h t Douglas Loftus is deeply grateful for the care his daughter has received, saying, “Alyssa would not have the life she has today if it were not for Cincinnati Children’s.” reasoned this drug might reduce the growth of tumors in patients with TS. F r o m G e n e D i s c o v e r y t o T r e a tm e n t New information about the genetics and molecular biology of tuberous sclerosis made this progress possible. Their insight opened the door to the first effective treatment. In the 1990s, researchers identified the TS mutation in two genes. By 2000, scientists had discovered that normally these genes control a protein, mTOR, that regulates cell growth throughout the body. They began to plan a clinical study of rapamycin and build the necessary infrastructure for the research. The pilot study tested whether rapamycin could reduce the size of kidney tumors in TS patients and prevent new tumors from growing. It was led by nephrologist John Bissler, MD, the world’s leading expert on the kidney complications of tuberous sclerosis. The research to identify the mTOR pathway was done by cancer biologists, but the Cincinnati Children’s TS team seized on the implications for tuberous sclerosis. In individuals who inherit the TS mutation, mTOR is overactive, causing uncontrolled cell growth and tumors. But there was an existing drug, rapamycin, that inhibits mTOR. The Cincinnati Children’s team As the trial began in 2003, there were doubters. Dr. Franz recalls, “The drug had been used for transplant and cancer patients. Skeptics asked what made us think 24 Jonathan Fields underwent two surgeries for brain tumors caused by tuberous sclerosis. When he developed another tumor in 2008, his physician in New York referred him to the clinical trial at Cincinnati Children’s. The medication has reduced the size of the tumor and given Jonathan a better quality of life. Jonathan’s family moved to Cincinnati last year to be close to care. it could fix a genetic condition. Some thought it might make the tumors worse.” the brain, Dr. Franz wanted to try it. Could it also shrink this patient’s brain tumor? It did–leading Dr. Franz and colleague Darcy Krueger, MD, PhD, to launch a study of TS patients with brain tumors. Exceeding Expectations “The families and patients who participated in the trial were more than equal partners in this research,” says Dr. Bissler. “They were courageous and altruistic.” While monitoring patients’ lungs, Dr. Bissler found that those with a dangerous lung disease– lymphangioleiomyomatosis (LAM)–showed improved lung function. LAM affects up to 40 percent of women with TS. Could rapamycin help them and others with LAM? A third trial was launched, led by pulmonologists Frank McCormack, MD, from the University of Cincinnati, and Bruce Trapnell, MD, from Cincinnati Children’s. As a precaution, Dr. Bissler monitored the brain and lungs of study participants for potential harmful side effects of the drug. This led the research in unexpected directions. One patient enrolling in the kidney trial was found to have a brain tumor. Early results of the kidney study suggested rapamycin was shrinking kidney tumors. Even though it was thought rapamycin did not penetrate The rare combination of wide-ranging expertise in one institution, along with a commitment to clinical 25 Dr. Franz recruited 28 patients at Cincinnati Children’s for a larger-scale brain tumor study. Alyssa was the 17th to enroll. She had developed a tumor that was rapidly growing and was facing the possibility of a very difficult brain surgery. After six months on the medicine, the tumor had shrunk 50 percent. In fact, tumors shrunk in all 28 patients. None required surgery for brain tumors after treatment. Of those with active epilepsy, 86 percent had seizures less often. L e ft Nephrologist John Bissler, MD (left), is the world’s expert on the kidney complications of tuberous sclerosis. Here he talks with research associate Brian Siroky, MD. R i g h t Misty Orlando Barnhart with Jo Coombs, RN. Misty was diagnosed with TS at age 14 and underwent surgery to remove a tumor-filled kidney at 19, but new tumors grew in her remaining kidney. She found the clinical trial at Cincinnati Children’s in 2010. “When I came here, the tumors were so big you couldn’t see my kidney,” she says. “Now you can’t see the tumors, and I have 100 percent normal kidney function. I call it my miracle.” The medicine reduced the size of kidney tumors in all participants. When it was stopped, tumors grew again in most patients. Of those with LAM, 70 percent had improved lung function that was partially sustained even after the medicine was stopped. research, made it possible for Cincinnati Children’s to lead simultaneous trials for kidney, brain and lung. In each case, results exceeded expectations. F i n a l l y , A n App r o v e d D r u g T h e r a p y Results of all these trials have been reported at professional meetings and in major medical journals, beginning in 2006 when Dr. Franz published data for the first five patients with brain tumors to be treated with rapamycin. Tumor size decreased in all patients. These initial findings supported the idea that inhibiting mTOR is an effective treatment, and led to larger followup studies. Dr. Bissler presented outcomes of his international follow-up study in February 2012. Kidney tumors shrunk in all patients who received the drug. 42 percent of patients experienced a 50 percent reduction in tumor size. In April 2012 the FDA responded to the data by granting expedited approval of the drug for noncancerous kidney tumors in TS patients. Within hours, Dr. Bissler started receiving calls from patients around the world wanting to come to Cincinnati Children’s for care. These results were reported in 2010. The FDA responded by granting accelerated approval of the drug for TS patients with brain tumors, while requiring a larger study. T r a n sf o r m i n g L i v e s The outcome of these clinical trials has been transformational for patients and extraordinarily gratifying for the doctors and nurses who work closely with them. “I have the best job in the world,” says Jo Coombs, RN. “We see truly amazing affects of this drug. It changes lives.” This next, placebo-controlled trial involved 117 patients at centers in the US, Canada and Europe. The outcome, reported at professional meetings in 2011 and published in 2012, confirmed the robust results of the initial study. Says Dr. Bissler, “The families and patients inspire us. It’s deeply gratifying that now we can actually do something that gives them hope for the first time.” A larger-scale LAM study was coordinated through a consortium of 13 institutions around the world. The findings, published in 2011, showed that the drug stabilizes lung function and improves patients’ quality of life. In 2012, a citizen’s petition requesting accelerated approval of the drug for treating LAM was filed with the FDA. Meanwhile multicenter research to confirm the study results are in progress. “I get passionate when I talk about it,” Doug Loftus acknowledges. “Alyssa would not have the life she has today if it were not for Cincinnati Children’s.” Dr. Bissler organized a placebo-controlled trial of kidney tumors. The national TS Alliance spread the word that Cincinnati Children’s was recruiting participants. 118 patients in 11 countries enrolled. Results of a two-year study of patients with kidney tumors, LAM or both were reported in 2008. Participants received the medicine for a year, followed by a year without it. 26 27 Charlotte Long is all smiles as she watches her grandson run and play at Cincinnati’s beautiful new Washington Park. “It’s wonderful to see him,” she says. “Last summer was really bad. He was sick a lot and couldn’t play outside.” Antonio Long was able to play outdoors this summer because his asthma is under control, thanks to an intensive education and support initiative at Cincinnati Children’s. G UIDIN G A S T H M A P A T IEN T S T O A Better Quality of Life Antonio Long, 4, suffers from asthma. Exercise is one of the triggers that starts him coughing and wheezing. health care nurses, inpatient and outpatient services, hospital staff and community partners. Before his asthma was under good control, breathing problems brought Antonio to the emergency department (ED) several times, and his grandmother, who is his guardian, missed work to take care of him when he was sick. For Antonio, the path to a better quality of life began last January, during a routine visit to the Pediatric Primary Care Center (PPCC) at Cincinnati Children’s. Knowledge and confidence Antonio and Charlotte enjoyed a happier summer this year, thanks to an intensive effort at Cincinnati Children’s to improve care for children with asthma. Because Antonio required emergency care several times in 2011, Charlotte was offered the opportunity to meet with Lauren Poling, one of two asthma care coordinators in the PPCC. T a r g e t i n g c o mm u n i t y h e a l t h i ss u e s Cincinnati Children’s strategic plan targets four major community health issues. Asthma is one of those priorities. Says Charlotte, “I’m so glad I took advantage of the opportunity.” Having a care coordinator means that Charlotte now has a teacher and an advocate to help reduce barriers to care. Charlotte counts on her if she has questions or concerns. “I feel comfortable calling Lauren when I’m unsure what to do,” she says, recalling one hot, smoggy day when she called to confirm when to give Antonio his medicine and how much to give. Poling was able to review the asthma care plan developed by Antonio’s provider and give her guidance. Asthma is the most common chronic disease of childhood and one of the top reasons children are admitted to the hospital. In Hamilton County, Ohio, one in six children has been diagnosed with asthma. The figure increases significantly for children who live below the poverty line. Our goal is to help patients improve control of their asthma to prevent ED visits and hospitalizations. The work is being accomplished through a large-scale collaboration of primary care doctors and pulmonary disease specialists, asthma care coordinators and home Poling also referred Charlotte to another service that made a difference: the Asthma Home Health Pathway. Since 2010, Cincinnati Children’s home health nurses 29 hospitals and organizations across the community to marshal health information technology to improve asthma care. The Department of Health and Human Services launched the Beacon Community Program in 2010 with grants to 17 communities, which are models for innovation using information technology to tackle leading health problems. The Greater Cincinnati HealthBridge collaboration is focusing on asthma and diabetes. a month’s supply of medicine and a copy of the child’s asthma care plan. In another improvement on the inpatient units, respiratory therapists now conduct an asthma risk assessment, using a checklist embedded in the hospital’s electronic medical record. The assessment identifies families who would benefit from an asthma care plan, education during the hospital stay, participation in the Asthma Home Health Pathway or referral to community resources. Because Antonio needed emergency care several times in 2011, he was referred to the asthma care coordinator in the Pediatric Primary Care Center. R i g h t Asthma care coordinator Lauren Poling (right) talks with Mona Mansour, MD, in the Pediatric Primary Care Center. L e ft have visited over 500 families to provide asthma care teaching in the home. “Education is everything,” Charlotte says. “I know I’m doing it right, and Antonio was learning with me. He knows how many puffs to take.” Cheryl Patterson, RN, visited Charlotte and Antonio six times over six months to reinforce the education Charlotte received in the hospital. A bundle of interventions She helped Charlotte identify things in the environment that can trigger Antonio’s asthma. She taught her to look for early signs of an asthma episode, so she can give Antonio medicine to stop the attack from getting worse. She reviewed the difference between controller medicine, which is given daily to reduce inflammation and prevent flare-ups, and rescue medicine, which is given as a fastacting treatment for wheezing and shortness of breath. And she coached Charlotte on how to fit the inhaler mask correctly so Antonio gets all the medicine into his lungs. 30 The same risk assessment tool is used by asthma care coordinators in our primary care clinics to assess highrisk patients and by our home health care nurses during home visits. Mona Mansour, MD, heads the Beacon program for the Cincinnati Children’s primary care clinics. She notes that “having regional alerts made us aware of patients who are eligible for asthma care coordination because of visits to providers outside of the hospital. It allows us to reach out to these patients, regardless of where they go for care.” When conventional treatment, care coordination and education aren’t enough, the hospital’s Asthma Center offers intensive, specialized care by pulmonary disease experts. P a r t n e r s i n t h e c o mm u n i t y Work to improve outcomes for children with asthma extends to collaborations with many partners in the community. Antonio’s asthma is under much better control, thanks to education and support that gave Charlotte the skills and confidence she needs to manage his care. One effort is a school-based asthma initiative at Rockdale and South Avondale elementary schools, both located near our main campus in the Avondale neighborhood. The asthma initiative also includes approaches designed to meet other challenges families face. Another is a long-standing asthma initiative with 38 community-based pediatric practices that are members of Tri State Child Health Services, a physician hospital organization. Collectively these practices serve 13,000 children with asthma in Greater Cincinnati. An Asthma Inpatient Task Force, led by hospitalist Jeffrey Simmons, MD, and Asthma Center director Carolyn Kercsmar, MD, spearheaded efforts to improve families’ access to asthma medications at home. Children who’ve had a hospital stay due to asthma now go home with In March, HealthBridge introduced an ED Admit Alert System that sends electronic alerts to primary care physicians when their patients with asthma or diabetes visit the emergency room in any of 21 area hospitals. All of these initiatives are keeping kids out of the hospital. Dr. Mansour reports that children admitted to the hospital for asthma are now 50 percent less likely to be readmitted or to be seen in the ED within 30 days, and are 23 percent less likely to return within 90 days. For high-risk children who receive asthma care coordination in our primary care clinics, the average number of days between ED visits or hospital admission has gone from 173 to 325 days. The numbers are impressive. But nothing is more impressive to Charlotte Long than watching Antonio run through the park. And as a participant in the Greater Cincinnati Beacon Collaboration, Cincinnati Children’s is working with 31 M A K IN G A DI F F ERENCE THE C O N V ALE S CENT H O S P ITAL F O R CHIL D REN EVOLVIN G , EDUCA T IN G , E M P O W ERIN G The hallmark of a successful organization is being nimble enough to meet the changing needs of the community. That is exactly what the Convalescent Hospital for Children has done for more than 180 years. While it closed its doors as a separate hospital a decade ago, the Convalescent Hospital has opened thousands more doors through its formal partnership with Cincinnati Children’s, bringing hope and healing to children and families in their time of need. Hospital for Children has continuously evolved to meet the most pressing needs of children and teens in our community and beyond. “Cincinnati Children’s and the Convalescent Hospital for Children have an impressive history of championing the care of children,” says Convalescent Hospital board member Pam Terp. “Today, we are working together to meet the complex needs of young adults with developmental disabilities.” From responding to the needs of children orphaned by a cholera epidemic in the 1830s to providing a resource for children suffering with chronic illnesses in the 1930s; from funding research to battle respiratory distress in premature infants in the 1980s to supporting the underserved needs of patients with mental illness in the 1990s, the Convalescent Project SEARCH is one of the more recent programs to benefit from the support of the Convalescent Hospital. Founded at Cincinnati Children’s more than 15 years ago, Project SEARCH is an internationally recognized job training program for people with significant disabilities. 32 L e ft Project SEARCH founder Erin Riehle, MSN, RN (center), with program graduates (l-r) Eric Johnson, Paul Wilson and Mary Bodle. R i g h t Project SEARCH graduate Jill Frambes works as a sterile processing technician at Cincinnati Children’s. The program partners with schools and a diverse cadre of employers to transition students with special needs from high school to meaningful employment. Project SEARCH opens new doors for its graduates and allows them to establish independence and build self-esteem. coupled with a passionate program leader and supported by a world-class organization, has created amazing outcomes. Project SEARCH has expanded to more than 200 programs in hospitals and businesses in 42 states and seven countries. More than 2,500 students participate in the program worldwide each year, with approximately 67 percent obtaining full-time employment by graduation. “What began with the vision and determination of one person has grown into a program that provides a future and a purpose to thousands of people with disabilities,” says Marie Huenefeld, a Convalescent Hospital board member and strong supporter of Project SEARCH. “One of the best parts is that so many former Convalescent Hospital children have benefited from the program.” “The Convalescent Hospital is very proud to partner with Cincinnati Children’s in this program,” Marie says. “It has been a thrill for all of us connected to Project SEARCH to watch the growth and impact it has had not only in Cincinnati, but across the US and around the world.” Convalescent Hospital’s investment in Project SEARCH has been instrumental to its success. Their partnership, 33 Partnership MA K E S THE Difference As a nonprofit hospital and research center, advance treatments and change the outcome Cincinnati Children’s relies on friends like you for children in Cincinnati, across the nation to provide hope and healing to the children and around the world. and families entrusted to our care. We are profoundly grateful to those who have Your partnership provides seed money to develop chosen to partner with Cincinnati Children’s new programs and services. Your support improves to advance discovery and help bridge what the quality, safety and reliability of pediatric happens in our research labs into improved healthcare. Your investment provides funding treatments and care. Together, we are for innovative research to prevent disease, improving child health. G I F T S T O CINCINNATI CHIL D REN ’ S Fiscal year 2012: July 1, 2011– June 30, 2012 UNRE S T RIC T ED ( 2 1 % ) RE S EARCH ( 4 1 % ) Supports the most pressing needs of the medical center. Advances groundbreaking discoveries that will improve care for kids in our community and around the world. $6,376,775 $12,730,129 $11,805,512 P A T IEN T CARE ( 3 8 % ) Provides expert family-centered care to all children entrusted to our care. T O T AL : $30,912,416 As a nonprofit hospital and research center, we are grateful for all gifts made to Cincinnati Children’s. Unless otherwise noted, this report lists all donors who gave $500 or more in fiscal year 2012 (July 1, 2011 through June 30, 2012). We have made every effort to be accurate and complete with this listing. Should you find an error or omission, please call the Department of Development at 513-636-6347. 35 D O N O R REC O G NITI O N Dr. and Mrs. Joseph A. Pichler Estate of Louis M. Sloan Leukemia and Lymphoma SocietySouthern Ohio The Procter & Gamble Fund Estate of Lova D. Riekert Hannah Jo Smith Research for Leukemia Foundation The H.B., E.W., and F.R. Luther Charitable Foundation Estate of Dr. George Rieveschl Jr. Estate of Joseph S. Stern Jr. John J. & Mary R. Schiff Foundation Estate of Ralph J. Stolle March of Dimes Foundation The Robert C. and Adele R. Schiff Family Foundation, Inc. The Sunshine Charitable Foundation Marriott International Estate of Leroy E. Schilling Mr. G. Richard Thomas Dr. and Mrs. Lester W. Martin Ruth Lyons Children’s Fund Cornerstone Contributors These generous supporters have made gifts to Cincinnati Children’s totaling $1 million or more. Because of their partnership, Cincinnati Children’s continues to be a leader among pediatric hospitals. Our research pioneers are changing the way doctors all over the world care for children. Our clinicians are able to provide state-of-the-art, family-centered care, and countless lives have been saved. Dr. and Mrs. Ira A. Abrahamson Jr. Kohl’s Department Stores Roger P. Schlemmer Toyota Motor North America, Inc. Mr.* and Mrs. Manuel D. Mayerson Charlotte R. Schmidlapp Fund Dr. and Mrs. Robert L. McLaurin Jacob G. Schmidlapp Trusts Western & Southern Financial Group Masters Dr. and Mrs. C. Nelson Melampy Marge & Charles J. Schott Foundation Louise A. Williams Trust The Oxley Foundation Michael M. Shoemaker Trust Estate of Louise S. Wilshire Fondation Leducq Ms. Jean L. Abrahamson Cincinnati Center for Developmental Disorders Foundation American Heart Association Mr. and Mrs. Thomas G. Cody Sr. Bill and Melinda Gates Foundation Anonymous (8) Mr. Reed L. Coen Association of Volunteers The Convalescent Hospital for Children General Electric Evendale Employees’ Community Service Fund Dr. and Mrs. Richard G. Azizkhan The Cooperative Society Emma Margaret Goldman Trust Patricia Heekin Briggs Dr. and Mrs. Alvin H. Crawford Estate of Irving Goldman Mrs. Lela C. Brown CURED The Greater Cincinnati Foundation Buckeye Foundation Charles H. Dater Foundation Marjory J. Johnson Trust Mr. and Mrs. David G. Bunning Boomer Esiason Foundation Ms. Lyn M. Jones Robert Rogan Burchenal Foundation Junior Co-Operative Society Estate of Dorothy S. Campbell James M. Ewell Charitable Remainder Trust Mr. and Mrs. Lee A. Carter Fifth Third Bank Robert T. Keeler Foundation Cincinnati Children’s Employees Mrs. Barbara J. Fitch Dorothy M. M. Kersten Trust Hemophagocytic lymphohistiocytosis (HLH)–two words that changed Dennis and Ann Flaherty’s life forever. Their son William was diagnosed with this life-threatening immunodeficiency disorder when he was only 3 years old. After a long battle that included a bone marrow transplant, William is now a happy and healthy 8-year-old, but Dennis and Ann haven’t forgotten how daunting the journey to the cure can be. The Children’s Heart Association The Flaherty Family Children’s Miracle Network Hospitals Food Allergy Initiative Kindervelt of Children’s Hospital Medical Center Determined to find a way to bring more awareness about the newly recognized disorder to the medical community, 36 Mrs. Mary Lou Tecklenburg Mr. Robert B. Gardner Ida C. Kayser Trust M A K IN G A DI F F ERENCE Dennis and Ann Flaherty to improve care for those diagnosed and to help families facing HLH, the Flahertys have provided seed funding for the HLH Center of Excellence at Cincinnati Children’s. The center is focused on four pillars– research, education, clinical care and family support. “This center will significantly change the outcome for families facing this disease through earlier detection, treatments and family-focused support,” Dennis says. “This journey can be extremely dark at times, and the HLH Center of Excellence at Cincinnati Children’s will be a beacon of hope.” 37 Individuals and Family Foundations Cincinnati Children’s is able to change the outcome for families because of our long-standing partnership with donors. We thank the many patients, families, staff and friends who have made charitable gifts to support our work. Each and every donor makes a difference in the lives of the families we serve. Anonymous (6) Dr. and Mrs. Ellis Arjmand Mr. Dee Ellingwood and Ms. Kaycee McGinley Dr. Stephen Levitt Dr. and Mrs. Richard G. Azizkhan Mrs. Barbara J. Fitch LKC Foundation Ted and Kim Beach Mr. and Mrs. Walter C. Frank Jerry and Tyra Markham Mr. Leonard H. Berenfield Mr. and Mrs. Thomas W. Gougeon Ms. Dee A. Martin Dr. Janet A. Borcherding Robert Gould Foundation Mrs. Martha H. McGraw Mr. and Mrs. Gene I. Mesh Andrea Lerner Levenson Mr. and Mrs. Brian K. Bourgraf Mr. Donald L. Grant $1,000,000 + Mrs. Mary Lou Tecklenburg Mr. and Mrs. Scott J. Hamlin Mr. and Mrs. Elroy E. Bourgraf Sr. Mr. and Mrs. James J. Gusweiler Mitch’s Mission The Flaherty Family Mr. G. Richard Thomas Mr. and Mrs. Terence L. Horan Mr. and Mrs. William C. Bray Mr. and Mrs. Clinton A. Haynes Ms. Gail Norris Dr. and Mrs. Robert L. McLaurin Nancy and David Wolf Mr. and Mrs. David C. Horn Mr. and Mrs. Thomas W. Brennaman Mr. and Mrs. Richard L. Hildbold Richard L. Hunt* Mr. and Mrs. Michael S. Cambron Mr. and Mrs. Ronald P. Ipach Ohio River Valley Combined Federal Campaign Mr. and Mrs. Donald J. Jaquet Mr. and Mrs. Lee A. Carter Marianne and Donald James Jane and Rob Portman Mr. and Mrs. Mitchell S. Meyers Dr. and Mrs. Brian D. Coley Mr. Brandon J. Janszen Mr. and Mrs. Andrew B. Quinn Mrs. Nancy M. Miller Mrs. Molly E. Kaplan* Dr.* and Mrs. Joseph L. Rauh Donald J. Moeggenberg* Dr. Robin T. Cotton and Ms. Cynthia M. Fitton Mr. and Mrs. Jeffrey Karsen Mr. and Mrs. Andrew S. Ritch Namaste Foundation The Crosset Family Fund Dr. and Mrs. Jeffrey Robbins Mr. and Mrs. Franklin W. Reilly Mr. and Mrs. Roger W. Dean Walter and Olivia Kiebach Charitable Foundation Trust Mr. and Mrs. Michael J. Sepela Mr. and Mrs. Thomas J. DiMarco Ellen and Mark Knue The Dodson Foundation Inc. The Ronald Kuntz Family Dr. Frederick C. and Mrs. Susan H. Ryckman Dr. Dennis Drotar and Dr. Peggy A. Crawford Denise and John Kuprionis Ms. Donna L. Schiff Dr. C. Dean Kurth Alan and Cheryl Schriber Dr. and Mrs. Joseph A. Pichler The Sunshine Charitable Foundation $50,000 – $99,999 Anonymous (2) $100,000 – $999,999 Henry and Elaine Fischer Anonymous (3) Dr. and Mrs. David L. Goldfarb Mrs. Lela C. Brown Mr. and Mrs. Timothy L. Mathile Mr. and Mrs. Thomas G. Cody Sr. Sophie’s Angel Run LLC. CURED Mr. Richard A. Weiland Michael and Suzette Fisher Food Allergy Initiative Joseph E. Ghory Allergy Fund of The Greater Cincinnati Foundation $25,000 – $49,999 Annie Wallingford Anderson Foundation Rudolph and Marie Simich Family Foundation Mr. and Mrs. Eric L. Smidt Elizabeth Mendenhall Anderson Foundation Mrs. Mauri Willis John J. & Mary R. Schiff Foundation Mr. James M. Anderson and Reverend Marjorie C. Anderson The Craig Young Family Foundation The Robert C. and Adele R. Schiff Family Foundation Inc. Anonymous (4) $10,000 – $24,999 Mr. and Mrs. Samuel M. Allen Mr. William J. Sinkula Dr. Nathaniel A. Chuang and Dr. Jeannie S. Huang Hannah Jo Smith Research for Leukemia Foundation Clack Foundation Inc. Amgis Foundation Dr. and Mrs. Alvin H. Crawford Mr. and Mrs. Robert D.H. Anning Liam’s Lighthouse Foundation Neena Rao Charitable Corporation 38 Mr. and Mrs. Gerald J. Robinson Mrs. Jean E. Wommack Alpaugh Foundation Children’s Circle of Care Individuals, couples and family foundations that gave $10,000 or more during calendar year 2011, or whose cumulative gifts have exceeded $1 million, are recognized as members of Children’s Circle of Care. Founded in 1995 by North America’s most prestigious children’s hospitals, Children’s Circle of Care honors the major benefactors of the 25 leading pediatric hospitals. 39 Skyler Foundation Mr. and Mrs. Ronald K. Chasteen Mrs. Mary Jane Schubert Dr. Lesley L. Breech and Dr. Jack B. Basil Dr. Cheryl L. Hoying and Mr. Joseph L. Hoying Mr. and Mrs. James L. Jaeger Mr. and Mrs. Mark D. Smith Madge Chidlaw* George W. and Elizabeth W. Kelly Foundation Dr. Joseph T. Stegmaier and Mrs. Barbara R. Sporck-Stegmaier Dr. and Mrs. Daniel I. Choo Mr. and Mrs. William M. Kent Mr. and Mrs. Marvin H. Schwartz Gerry and Bill Cowlin Foundation Mr. and Mrs. Daniel E. Kincaid The Scoliosis Foundation Dr. Rebeccah L. Brown and Mr. Dan O. Jones Mr. and Mrs. Terry S. Karageorges Ms. Elizabeth A. Stautberg The Robert and Christine Steinmann Family Foundation Mr. and Mrs. Harold W. Still Mr. and Mrs. Peter S. Strange Mr. and Mrs. Bernard P. Suer The Sutphin Family Foundation The Richard H. Sutphin Family Foundation JS Turner Family Foundation Dr. and Mrs. Daniel von Allmen Mr. and Mrs. Gary W. Wright Mr. and Mrs. Robert S. Yeakle YOT Full Circle Foundation Schwab Charitable Fund Mr. Thomas A. Johnson Mr. and Mrs. James R. Cummins Mr. and Mrs. Thomas E. Kinman Mr. and Mrs. Joseph C. Seta Mr. and Mrs. William B. Brown Jr. Mr. and Mrs. Thomas J. Danis Mr. and Mrs. Daniel P. Klare Mr. Jay Shaw Ms. Joyce J. Keeshin John & Shirley Davies Foundation Dr. and Mrs. Frederick W. Koch Mr. and Mrs. David L. Singer Mr. and Mrs. Danny R. Brummett-Mason Colin J. Dembo Memorial Foundation Mr. and Mrs. Robert B. Stein Jr. Mr. and Mrs. Jeff Klare Amy Diamond and Family Edward T. and Blanche C. Korten Charitable Fund Mr. and Mrs. Robert K. Citrone Mr. and Mrs. Paul C. Koch Mr. and Mrs. Richard A. Dineen Arthur and Elizabeth Kuhn Fund Mrs. Barbara E. Stern Mr. William C. Clasen and Ms. Kathleen Winter Mr. and Mrs. George A. Dunn Jr. Mr. John E. Lanier and Ms. Jane E. Garvey Mrs. Mary L. Strutz Mr. and Mrs. Joseph T. Lukens Jr. Mr. Jerome F. Tatar Dr. Nancy K. and Mr. David A. Eddy Mrs. Trudie R. Ficks Mrs. Roberta S. Fisher Donald and Deborah Gilbert Mrs. Jocelyn H. Glass Dr. and Mrs. James M. Greenberg Mr. and Mrs. Thomas T. Gregory $5,000 – $9,999 Mr. and Mrs. Harold B. Guttman Helen T. Andrews Foundation Mr. and Mrs. Louis B. Guttman Anonymous Mr. and Mrs. Joseph P. Hayden III Dr. Diane S. Babcock Ms. Casey Hilmer Drs. Wynndel P. Baldock and Elisabeth E. Baldock Mr. and Mrs. Michael A. Hirschfeld Mr. and Mrs. Andrew L. Berman Dr. Margaret K. Hostetter Mr. and Mrs. Robert W. Blackmore III Mr. and Mrs. Andrew J. Johnson Mr. and Mrs. William B. Brown III Ms. Madeleine Burmester The Raymond C. and Anna T. Johnson Foundation Inc. Dr. and Mrs. Steven C. Carleton Mr. and Mrs. Thomas M. Keckeis Mr. Michael J. Hoogeveen 40 Mr. and Mrs. Millard H. Mack Anne S. and James J. McGraw Jr. The Mead Foundation Blanche M. and Herbert A. Metzger Memorial Fund Mr. James A. Miller Morgan Family Foundation Mr. and Mrs. John W. Steinman III Mr. and Mrs. Davis M. Tapp Mr. and Mrs. Alexander Thomson III Max Richard Thornsbury Foundation Mr. Alan S. Threlkeld Mr. and Mrs. Terry L. Tranter Mr. and Mrs. David I. J. Wang Mr. Jonathan Zipperstein Mr. Robert L. Collins Dr. Sandra J. Degen and Dr. Jay L. Degen Mr. and Mrs. Robert E. Donelan Jr. Ms. Sonia L. Donoher Dr. Lorah D. Dorn Mr. and Mrs. David F. Dougherty Mr. and Mrs. David W. Ellis III Mr. and Mrs. John H. Enneking III Ms. Margaret A. Everist Dr. Ardythe L. Morrow and Mr. Kenneth R. Haag $2,500 – $4,999 Mr. and Mrs. Wayne I. Fanta Mr. and Mrs. Michael J. Abbinante Dr. and Mrs. Michael K. Farrell Dr. and Mrs. Martin J. Murphy Anonymous Mrs. Sandy L. Fritz Dr. Arthur M. Pancioli and Dr. Rita M. Girard Dr. and Mrs. Mark C. Ault Mr. and Mrs. William J. Gentner Mr. and Mrs. Michael B. Baughan Mr. and Mrs. Matthew T. Hanson Nina and Edward Paul Ms. Marty Betagole Mrs. Phyllis Harlow Dr. John P. Perentesis and Dr. Stella M. Davies Dr. Francis M. Biro and Ms. Nancy L. Bloemer John and Carrie Hayden Family Foundation Mr. and Mrs. Bernie Rabinowitz Mr. and Mrs. Gary S. Bohn Mr. and Mrs. Paul L. Helpling Dr. and Mrs. Robert C. Schiff Jr. Mr. and Mrs. Robert A. Bowen Mr. Aaron Hempfling 41 Mr. and Mrs. Roy C. Kiessling Jay and Karen Kratz Dr. Catherine L. Krawczeski and Mr. Richard A. Krawczeski Mr. Michael Kresser Dr. Ann W. Kummer Mr. and Mrs. Christopher D. Lah IV Mr. John LaRocca Mr. and Mrs. Jeffrey W. Lazarow Mr. Jie Li Dr. and Mrs. Philip K. Lichtenstein Mr. and Mrs. Douglas P. Loftus Dr. and Mrs. Daniel J. Lovell Dr. and Mrs. Francesco T. Mangano Mr. and Mrs. Michael E. Martin Mr. and Mrs. Scott Mattis Mr. Ken May Dr. Jaclyn W. McAlees and Mr. Marcus McAlees Dr. and Mrs. John E. McCall Mr. and Mrs. George M. Menyhert Mr. Steven Messer Mr. and Mrs. Jeffrey R. Anderson Jr. Mr. and Mrs. Douglas S. Brown Mr. and Mrs. Steven A. Cirino Mr. and Mrs. Daniel H. Demmerle II Mr. Peter D. Morey and Dr. Bernadette L. Koch Dr. Parke G. and Dorothy M. Smith Foundation Mr. and Mrs. Rob H. Anning II Mr. James M. Brown Dr. Douglas F. Clapp Mr. and Mrs. Paul DeNicolo The Philip Smith Foundation Anonymous (3) Mr. James W. Brown Mr. and Mrs. James W. Cochran Mr. and Mrs. Andrew E. DeWitt Ms. Anne K. Morton Mrs. Violet K. Solomon Mr.* and Mrs. Neil A. Armstrong Dr. Pamela I. Brown Dr. and Mrs. Thomas G. DeWitt Mr. Todd Moss Mr. and Mrs. Russell L. Speed Mr. and Mrs. James Barter Bruce Family Foundation Dr. Mitchell B. Cohen and Dr. Morissa Cohen Dr. and Mrs. Louis J. Muglia Mr. and Mrs. Michael L. Bauer Mr. and Mrs. Daniel W. Brummett Mr. and Mrs. Thomas P. Collins Mr. and Mrs. David W. Deye Dr. and Mrs. Charles M. Myer III Dr. Lori J. Stark and Mr. Eric A. Grohsgal Mr. and Mrs. Charles E. Baverman Jr. Mrs. Cynthia Burnett Dr. Beverly L. Connelly Dr. and Mrs. Scott E. Dillingham Mr. and Mrs. Suresh Nirody Mr. Daryl Strother Mr. and Mrs. Michael Beard Mr. and Mrs. Stephen R. Burns Mr. and Mrs. Dave Cook Dr. Mark S. Dine Mr. James R. Office Mr. and Mrs. Gary Sullivan Mr. and Mrs. Edward D. Beckman Mr. and Mrs. Frank D. Buttari Mr. and Mrs. Dannah J. Crosby Alex Dinkel Foundation The Richard and Dorothy Pandorf Foundation Mr. and Mrs. Michael J. Sylvester Mrs. Cindi Bedinghaus Mr. and Mrs. Kerry R. Byrne Mr. and Mrs. Richard J. Beiting Mr. Ian Pinales Mr. and Mrs. Thomas T. Terp Mr. and Mrs. Stephen J. Beiting Mr. Michael Camacci and Ms. Diana L. Collins Dr. Michael H. Cynamon and Ms. Wendy Ressler Mr. James R. Doellman Mr. and Mrs. Steve Sylvester Ms. Sarah Dailey Mr. and Mrs. Peter H. Dworjanyn Mr. and Mrs. Paul S. Preston Dr. and Mrs. Thomas U. Todd Mrs. Lois G. Benjamin Mrs. Tiffanne Campbell Mr. and Mrs. Clayton C. Daley Jr. Ms. Lalita Duggal Drs. John and Judy Racadio Dr. and Mrs. Jeffrey A. Towbin Mr. Stephen S. Campbell Lewis and Marjorie Daniel Foundation Mr. Darryl Echoles Mr. Raja Ram Ms. Robin Uhl Mr. Travis Bible Mr. Thomas J. Cash Mr. and Mrs. Richard Darlington Mr. and Mrs. William R. Eckerle Dr. and Mrs. Stephen M. Rauh Mr. and Mrs. Michael D. Valentine Drs. David and Elaine Billmire Ms. Susanne M. Cassidy Mr. and Mrs. Shailaja Datla Mr. and Mrs. Ian S. Edwards Mr. William R. Remke Mr. and Mrs. Ray Van Der Horst Mr. and Mrs. Erik Bjerke Ms. Carrie A. Cassis Mrs. Katharine M. Davis Mr. and Mrs. Barry N. Ehrnschwender Ms. Erin Riehle Dr. and Mrs. Jeffrey A. Whitsett Mr. and Mrs. Michael J. Cebo Dr. and Mrs. Adekunle H. Dawodu Mr. and Mrs. Richard H. Elder Rose Family Fund Mr. Brian R. Wildman Dr. Melodie G. Blacklidge and Mr. Kenneth Dunn Mr. and Mrs. Scott L. Chandler Mr. and Mrs. Patrick J. Dearing Mrs. Susan Rutkowski Mr. and Mrs. Jay V. Wittenbaum Dr. Barbara A. Chini and Mr. Paul V. Janavicius Mr. and Mrs. Charles A. DelGrande Gene and Neddie Mae Elkus Family Foundation Mr. and Mrs. Randall L. Delk Mr. and Mrs. John H. Elms Mr. and Mrs. James A. Saporito Mr. and Mrs. Morgan S. Schafer Mr. and Mrs. Brett Schappacher Mr. Matt Schmitz Mr. and Mrs. Jeffrey N. Schner Mr. and Mrs. Gregory W. Schube Mr. and Mrs. Gerald S. Skidmore Catharine S. Smith, C. Kenneth Smith, and Philip S. Smith Family Fund Mr. Richard L. Betagole Mr. Thomas H. Blalock Mr. and Mrs. James M. Blanton $1,000 – $2,499 Mr. and Mrs. Donald E. Able Mr. and Mrs. John T. Acklen Mr. and Mrs. James R. Adams Mr. and Mrs. Michael V. Downing Mr. and Mrs. Arlen D. Bockhorn Mr. and Mrs. Damon D. Bowling Mr. and Mrs. James P. Boyce Dr. Evaline A. Alessandrini and Mr. Thomas F. Alloy Dr. Rebecca C. Brady Dr. Raouf S. Amin and Dr. Amal H. Assa’ad Mrs. Eleanor J. Brenan Dr. Maria T. Britto Mr. Robert A. Anderle Mr. and Mrs. Aaron L. Broomall 42 Mr. and Mrs. William O. DeWitt Jr. Mr. and Mrs. Richard D. Branson Schubert Society Employees of Cincinnati Children’s who give $1,000 or more in a fiscal year are recognized as members of the William K. Schubert, MD, Society. Named for the beloved and greatly missed pediatrician and dedicated leader of the medical center, this society honors those who follow Dr. Schubert’s example of generous philanthropic support. 43 Dr. and Mrs. Richard A. Falcone Jr. Mrs. Kimberly Goins Ms. Mary Maureen Heekin Mr. and Mrs. Tony L. Johnston Susan and Roy Kulick Dr. Mona E. Mansour Mr. and Mrs. D. Vincent Faris Mr. and Mrs. Kevin C. Gold Mr. Paul Heiman Dr. and Mrs. Blaise V. Jones Mr. and Mrs. Donald P. Laden Mr. and Mrs. Randall G. Marsh Ms. Jena Feichtner Mrs. Amanda J. Goldsmith Mr. and Mrs. Jeffrey K. Heinichen Mr. and Mrs. David J. Josephic Mr. Chris D. Lahna Mr. and Mrs. Luke S. Martin Mr. and Mrs. Thomas B. Feldmann Dr. and Mrs. Stuart L. Goldstein Dr. and Mrs. Michael A. Helmrath The Juilfs Foundation Dr. Tal Laor Mr. and Mrs. Alexander R. Marx Mr. and Mrs. Thomas M. Finn Mr. and Mrs. Robert P. Goodwin Mr. and Mrs. William J. Hemingway Mr. and Mrs. Joseph Lapinsky Mr. and Mrs. Clayton L. Mathile Mr. and Mrs. Marc E. Flick Mr. and Mrs. Bradley M. Govert Mr. and Mrs. Keith Henize Dr. Karen A. Kalinyak and Mr. Joseph G. Martin Mr. and Mrs. John P. Larson Mr. and Mrs. Brian May Mr. and Mrs. Timothy J. Fogarty Mr. Louis C. Graeter II Mr. and Mrs. Daniel F. Henke Mr. and Mrs. Carl F. Kalnow Ms. Michele Laumer Mr. and Mrs. Joshua K. Mayers Mr. and Mrs. William W. Ford III Mr. and Mrs. Michal L. Grau Mr. and Mrs. Robert J. Herman Mr. and Mrs. Bill E. Katz Mr. and Mrs. Simati L. Laupola Dr. and Mrs. David C. Mayhaus Mr. and Mrs. William A. Forrester Mr. and Mrs. Frederick H. Gribbell The Herzog-Beckman Foundation Ms. Stacy Katz Mr. Eric Lavender Dr. and Mrs. John J. McAuliffe III Mr. Gary Franke Mr. Thomas W. Griffiths Mr. Ronald G. Hess Dr. and Mrs. Andrew V. Kayes Mr. Ernest Lawhorn Mr. John McCann Dr. and Mrs. James E. Heubi Dr. and Mrs. Gary L. Keller Ms. Ruth Lebow Dr. and Mrs. James J. McCarthy Mr. and Mrs. John A. Kerechek Mr. William T. Lecher Mr. and Mrs. Kevin T. McCormick Mr. and Mrs. John W. Leikhim Mr. and Mrs. Mark B. McDonald Mr. and Mrs. James R. Frebis Mr. and Mrs. Thomas N. Haas Mr. and Mrs. Stephen F. Frey Mr. and Mrs. Michael J. Habel Dr. and Mrs. Harry F. Fry Ms. Jamilah Hackworth Mr. Ron Hicks and Ms. Michele Fronckiewicz Mr. and Mrs. Christopher S. Frye Mr. and Mrs. Gary G. Hagopian Mr. and Mrs. James L. Hill Mr. Stephen J. Knox and Ms. Betsy Kiley Dr. and Mrs. Marc A. Levitt Mr. Robert W. McDonald Hainline Family Foundation Mr. and Mrs. Max W. Hillman Jr. Mr. and Mrs. Steven C. Kimball Mrs. Barbara G. Lewis Mr. Powell McHenry Ms. Joy E. Hamilton Mr. and Mrs. Harlyn J. Hubers Dr. Eileen C. King and Mr. Dennis W. King Mr. and Mrs. Jeffrey A. Litmer Ms. Vicki M. McIver Mr. and Mrs. William J. Fussinger Mr. and Mrs. John A. Gaskey Ms. Joan M. Gates Mr. and Mrs. Jason E. Hammann Mr. and Mrs. Robert C. Hughes Dr. and Mrs. Rodney P. Geier Ms. Michele Hanson Mrs. Martha G. Huheey Dr. and Mrs. John W. Klekamp Dr. Mitchel D. Livingston and Mrs. Carol Livingston Dr. Michael J. and Dr. Janelle A. Gelfand Ms. Roberta S. Harding Ms. Mary Jo Hutchins Ariana Knue Dr. and Mrs. Daniel McLinden Mr. John J. Locaputo Mr. and Mrs. Arthur F. McMahon III Dr. Parameswaran Hariharan and Dr. Lalitha Hariharan Ms. Tracy Inman Carly Knue Ms. M. Anne Longo Mr. and Mrs. James H. Irvine Zachary Knue Dr. Charles T. Mehlman and Dr. Elsira M. Pina Mr. and Mrs. Brian R. Jacob Mr. and Mrs. Peter C. Koch Mr. and Mrs. William S. Giesler Robert & Helen Harmony Fund For Needy Children Dr. Sarah L. Lopper and Mr. Jeffrey A. Lopper Mr. and Mrs. Harold Jarnicki Mr. and Mrs. Louis Koenig Ms. Barbara L. Glassmeyer Mr. and Mrs. Richard T. Jinks Mr. and Mrs. Chase M. Kohn Mr. George B. Lott and Ms. Barbara N. Wurth Dr. and Mrs. C. Nelson Melampy Mr. Danny D. Harris Ms. Julie M. Glassmeyer and Mr. Paul D. Berlage Mr. and Mrs. John Hartz Dr. and Mrs. Alan H. Jobe Mr. and Mrs. Curt W. Koslovsky Mrs. Elizabeth Lovett Grover Ms. Patricia L. Messmer Mr. and Mrs. Timothy J. Hastings Mrs. Arlyn T. Johnson Dr. Alice Kreisle and Mr. Jon Bormet Dr. Maurizio Macaluso Mr. and Mrs. Matthew J. Meyer Ms. Patricia A. Johnson Mr. and Mrs. David J. Krier Mr. and Mrs. Carlos F. Mahaffey Mr. and Mrs. Edward J. Millar Mr. and Mrs. Rick L. Johnson Mr. Gerard Kroger Mr. and Mrs. Kenneth M. Mailender Mr. and Mrs. J. Michael Miller Mr. Robert A. Johnston Mr. and Mrs. Joseph M. Kroner Mr. David B. Malik Mr. Kelly T. Miller Mr. Kevin E. Gessner Mr. and Mrs. Karl J. Gieseke Dr. and Mrs. Jack L. Gluckman Mr. and Mrs. Christopher S. Hatcher Mrs. Deane B. Godfrey Mr. and Mrs. John L. Hausfeld Mr. and Mrs. Robert A. Goering Mr. and Mrs. Keith A. Hazlewood 44 45 Ms. Sharon M. McLeod Mrs. Jodi Meister Ms. Kristin R. Melton Ms. Maura L. Moran Mrs. Christine Opdycke Ms. Judith R. Ragsdale Mr. George E. Morgan III Dr. and Mrs. Joseph J. Palermo Jr. Mr. and Mrs. Robert D. Rands Mr. Tim and The Honorable Kathleen Rodenberg Mr. and Mrs. Steve Singleton Mr. Timothy M. Timmers Dr. and Mrs. Michael L. Mucenski Mr. and Mrs. Ronald A. Panioto Jr. Mr. and Mrs. Doug B. Rawlings Mr. and Mrs. John W. Rogers Mr. and Mrs. James A. Sluzewski Ms. Patricia M. Tobergte Dr. and Mrs. Stephen E. Muething Dr. Ruben Papoian and Ms. Lynn Briggs Red Bird Hollow Foundation John G. Smale* Mr. and Mrs. Paul H. Tobias Mr. and Mrs. Alan W. Mullins Mr. and Mrs. Paul A. Pappenheimer Jr. Dr. Pramod P. Reddy and Dr. Usha P. Reddy Ms. Nicole R. Rotunno and Mr. Robert F. Rogas Mr. and Mrs. Tim Smallwood Dr. Joseph C. Todd Mr. and Mrs. Jerry L. Rutherford Dr. Joel N. Myers Mr. and Mrs. John C. Myers Mr. Jason W. Napora and Ms. Alison Momeyer Mr. and Mrs. Christopher J. Parker Dr. Alice A. Passer and Mr. Barry I. Krieger Dr. and Mrs. William S. Pease Mr. Steve M. Singer Ms. Terri L. Thrasher Mr. Christopher J. Smith Mr. and Mrs. Mark W. Townsend Richard D. Reis Family Foundation Mr. and Mrs. William E. Rutz Solomon/Rau Family Mr. and Mrs. Glenn A. Travis Mr. and Mrs. Gregory W. Renzenbrink Dr. and Mrs. Howard M. Saal Dr. and Mrs. Imre Solti Mr. and Mrs. Anthony M. Sansalone Mrs. Gayle P. Riemer Mr. and Mrs. Anthony C. Saladonis Mr. and Mrs. James W. Sowar Jr. Mr. and Mrs. Charles W. Turner Jr. Mr. and Mrs. Timothy E. Needham Dr. and Mrs. Robert C. Pence Mr. and Mrs. Brad A. Rife Mr. and Mrs. Michael E. Saxion Paul and Karen Sparling Mr. and Mrs. Douglas Tyger Dr. David P. Nelson Mrs. Sandra S. Perry Mr. and Mrs. William R. Saxton Mr. and Mrs. Frederick S. Spohr Dr. Judith B. Van Ginkel Mr. and Mrs. Hale Newman Mr. and Mrs. James P. Pilcher Dr. Isidro Risma and Dr. Kimberly A. Risma Ms. Anne Scharff Dr. and Mrs. S. Andrew Spooner Ms. Laura C. Nixon Mr. and Mrs. John J. Planes Jr. Mr. and Mrs. Eppa Rixey IV Mr. and Mrs. Alan M. Schell Dr. and Mrs. Paul E. Steele Mr. Herbert L. Venable and Ms. Julia Abell Mr. and Mrs. John Nordmeyer Mr. and Mrs. Kim F. Pleggenkuhle Mr. and Mrs. Danny L. Roark Ms. Mary A. Schell Mr. and Mrs. Joe Steinert Carl S. and Stephanie M. Vorhoff Ms. Debbie H. Ogden Ms. Carrie Pollick Reuben B. Robertson Foundation Mr. Thomas R. Schiff Dr. Mark C. Steinhoff Ms. Lynn R. Olman Mr. Jay R. Purdy Mr. and Mrs. Alan G. Schmidt Ms. Yvonne E. Stepter Mr. and Mrs. Christopher and Kathleen Vuturo Mr. and Mrs. David B. O’Maley Mr. and Mrs. Kevin E. Quill Dr. Nicole C. Robinson and Dr. Bryce Robinson Mr. and Mrs. Stephen J. Schmitz Mrs. Amy Stoll Susan Wade Murphy Dr. David P. Schor and Ms. Susan M. Elek Dr. and Mrs. Arnold W. Strauss Mr. James T. Walker and Ms. Kathleen A. Furlong Mr. John T. Schwierling Jr. M A K IN G A DI F F ERENCE Ms. Elizabeth Schumacher Ms. Mary Beth Schutter Joe and Susan Pichler Joe and Susan Pichler have known many families whose children have received exceptional care at Cincinnati Children’s, often for conditions that require sophisticated analysis and treatment. These experiences led them to talk with Arnold Strauss, MD, chair of the Department of Pediatrics, who told them of the critical need to expand treatment programs for children and teens suffering from mental illness, an area of medicine that is often underserved and underfunded. The Pichlers responded with a significant gift in support of the Partial Hospitalization Program, which provides inpatient therapeutic care for children and adolescents in a daily, nine-hour program that allows them to go home to their families each night. 46 Mr. Christopher M. Scowden Dr. Robert A. Shapiro and Ms. Elaine E. Fink Ms. Julie Ann Shaw Mr. and Mrs. David L. Shelton Mr. John M. Shepherd Mr. and Mrs. Joseph M. Sims Mr. Richard Stuart Mr. and Mrs. Gail R. Stultz Mr. and Mrs. Brian Sullivan Ms. Kathleen M. Sullivan Mr. and Mrs. Paul M. Sullivan III Ms. Regina C. Surgener Dr. Alexandra Szabova Dr. Nicole M. Tepe and Mr. Matthew Wortman Mr. James W. Thompson Mr. Robert W. Thompson 47 Mr. and Mrs. Jason A. Walker Mr. Richie Walker Mr. and Mrs. John Waltz Mr. and Mrs. William H. Ward Dr. Gary D. Webb Mr. and Mrs. Brian A. Webb Mr. and Mrs. Andrew A. Webster The Weichert Kranbuhl Family Foundation Dr. and Mrs. Derek Wheeler Mr. and Mrs. Richard H. Wick Dr. and Mrs. Bruce J. Aronow Dr. Daniel T. Brown and Mr. Mark R. Haggard Dr. and Mrs. Kerry R. Crone Mr. and Mrs. Kenneth R. Elder Mrs. Joyce R. Wilhelm Dr. Cindy J. Bachurski Mr. and Mrs. Jeffrey Willett Mr. and Mrs. Timothy J. Bankes Mr. and Mrs. Charles E. Curran III Dr. and Mrs. Ravindhra G. Elluru Dr. and Mrs. Jack W. Gottschalk Mr. and Mrs. John Curro Mr. Gilbert Embry The Charles M. Grant Foundation Mr. and Mrs. Bernard M. Barbash Dr. Jennifer M. Brown and Mr. Richard T. Brown Dr. and Mrs. J. Paul Willging Mr. and Mrs. Terry L. Davies Mr. and Mrs. Mark A. English Mr. Joseph N. Green Ms. Cheryl D. Bauer Ms. Kim R. Brown Mr. and Mrs. Craig M. Davis Mr. Jeffrey Engram Dr. and Mrs. John H. Greinwald Jr. Mr. Richard L. Bere Mr. and Mrs. Larry J. Brueshaber Mrs. Kathleen G. Davis Mrs. Roberta Winters Mrs. Mildred Berning Dr. and Mrs. Alessandro de Alarcon Dr. Kelly T. Epplen and Mr. Michael F. Epplen Mr. James M. Grodnick Mr. and Mrs. Michael E. Brunner Mr. David Wiser Mrs. Arlene Bertellotti Mr. and Mrs. Stephen D. Bryen Mr. and Mrs. Jeffrey R. Decker Mr. and Mrs. William T. Fagin II Dr. Neera Gulati Mr. and Mrs. Michael R. Witte Mrs. Janet Betts Mr. and Mrs. Mark E. Buchheit Dr. D. Robert Haas The Farmer Family Foundation Beth Joanna Habbert Memorial Fund Ms. Gin L. Wong Mr. Mark S. Bever and Ms. Nancy J. Burns Dr. William R. DeFoor and Dr. Catherine A. DeFoor Ms. Karen Fahlgren Mr. and Mrs. Michael W. Burlingham Ms. Jessica H. Byerly Mr. and Mrs. James K. Dempsey III Mr. and Mrs. Gregory M. Feary Mr. and Mrs. David W. Hammer Wood-Byer Foundation Mr. and Mrs. Paul Beyer Jr. Dr. Donita Bylski-Austrow Ms. Dawn M. Denno Mrs. Robin L. Felty Mr. and Mrs. David E. Hampton Dr. Linda L. Workman Dr. and Mrs. Jorge A. Bezerra Dr. Marc M. Cahay Mr. and Mrs. Jeffrey DeRossette Mr. and Mrs. David L. Fisher Mr. and Mrs. James N. Harjo Sr. Mr. and Mrs. Douglas S. Bible Ms. Barbara Campbell Dr. Peter Dickie Mr. and Mrs. Marc D. Fisher Mr. and Mrs. John C. Hartman Marilyn and Thomas Zemboch Mr. and Mrs. Robert A. Bitter Mr. and Mrs. Robert A. Carpenter Mr. Richard Dobson Mr. and Mrs. Brian Florko Mr. and Mrs. Michael D. Hartman Mr. James Zenni Mr. and Mrs. Tom Booth Mr. and Mrs. Samuel M. Cassidy III Mr. and Mrs. Richard D. Dobson Mr. and Mrs. Jeremy D. Focht Mr. and Mrs. Steven R. Hartman Ms. Sharon E. Ziegler Mrs. Monica Borell Mr. and Mrs. Ryan K. Chambers Mrs. Clarissa C. Doggett Mr. and Mrs. Earl D. Folker The Hayden Foundation Mr. and Mrs. Ronald R. Borgman Mr. Weiguo Chen Mr. and Mrs. Ronald J. Dolan Mr. and Mrs. David E. Foxx Dr. Daniel Heffernan Mr. and Mrs. Thomas W. Bosse Mr. and Mrs. Kyle M. Chirico Mr. and Mrs. James M. Dole Mr. Steven L. Frank Mr. and Mrs. Anthony E. Helton Mr. and Mrs. Charles Bost Mr. Kevin M. Clark Ms. Lisa Dorriere Mr. and Mrs. Ralph Freiberger Colonel and Mrs. Thomas Henwood Ms. Mary A. Bowling Mr. and Mrs. Michael P. Cloughessy Mr. and Mrs. Donald J. Doyle Jr. Mr. Alan P. French Mr. and Mrs. Gerald L. Heringer Ms. Catherine O. Bradford Mr. Timothy J. Collins Mr. and Mrs. Richard J. Driscoll Mr. and Mrs. Donald C. Fritz Mr. and Mrs. Christopher N. Herrell Dr. and Mrs. Kim Brady Mr. and Mrs. Fred Cooper Mr. and Mrs. Gary G. Drook Mr. and Mrs. Daniel J. Gahl Mr. and Mrs. Gregory L. Herrin Mr. and Mrs. Joseph A. Brant Ms. Melinda S. Corcoran Mr. and Mrs. Dana M. DuBois Mr. and Mrs. Lawrence R. Gamblin Mr. and Mrs. Theodore F. Herschede Mr. Mark Brasington Mr. and Mrs. Gary G. Cox Mr. and Mrs. Christopher A. Dyer Mrs. Susanne E. Geier Mr. Stephen Breech Dr. and Mrs. Edward J. Crane Ms. Stephanie Ebken Mr. John B. Goering Dr. Andrew D. Hershey and Dr. Gurjit Khurana Hershey Mr. and Mrs. Jerome A. Brehm Mr. John Craynon Mr. and Mrs. Jeffrey G. Hester Mr. John W. Brod Ms. Elli Edwards and Mr. Michael Scarpa Mrs. Dolores S. Goldfinger Dr. and Mrs. Michael D. Crenshaw Mr. Jack Goldsmith Mr. Donald Hiler Dr. and Mrs. Alan S. Brody Dr. Gail Croall and Mr. David T. Croall Mr. and Mrs. W. Charles Ehlers Ms. Kathleen Good Mr. John J. Hill Mr. and Mrs. Wayne A. Williams Dr. and Mrs. Stephen Wilson Dr. and Mrs. Edward J. Wnek Dr. and Mrs. Richard A. Yauss $500 – $999 Ms. Ngqika Abdul-Khabir Dr. Denise M. Adams and Mr. Christopher S. Adams Mrs. Ruth Adams Mr. and Mrs. James T. Aglamesis Dr. and Mrs. Henry T. Akinbi Mrs. Sharon L. Andersen Ms. Michelle L. Annis Anonymous (2) Mrs. Wilma D. Anthony 48 49 Ms. Erin Gore Mr. Charles R. Grone Mr. and Mrs. Thomas G. Hoel Mr. Kenneth Kemen Dr. and Mrs. Ronald S. Levin Mr. and Mrs. William G. McBrayer III Mr. and Mrs. David D. Hoguet Mr. Michael R. Kemer Mr. and Mrs. Ozzie Levine Mr. and Mrs. Irving W. Horowitz Mr. Steven Kenat and Ms. Heidi B. Jark Mr. and Mrs. James I. Lewis Mr. and Mrs. Terry L. House Mr. James R. Kimmel Mr. and Mrs. Michael Leyritz Mr. and Mrs. James R. Huesing Mr. and Mrs. Paul W. King Ms. Elizabeth J. Hunt Ms. Angela Kinstler Mrs. Diana L. Nordling Ms. Mara M. McClellan Mr. Nicholas P. Miller and Ms. Hillery A. Banawitz Mr. Edward L. McClure Mrs. Arlene F. Mitchell Dr. and Mrs. Thomas R. Nymberg Mrs. Judy A. Moermond Mr. Michael F. O’Connor Mr. and Mrs. Ralph W. Little Mr. Scott McDermott and Ms. Shannon Studebaker Mr. and Mrs. John A. Monroe Ms. Mandy O’Leary Mr. Mark Lloyd Mr. and Mrs. Robert E. McEwan Mr. Richard T. Morgan Mr. Michael E. Ollinger Mr. and Mrs. Richard C. Morris Jr. Dr. Lauren R. Ostling Mr. and Mrs. Robert P. Nordloh Dr. Lisa L. Hunter and Mr. Richard W. Smolak Ms. Shawna K. Kirkendall Mr. and Mrs. John A. Lobono Mr. Sarah McGough Mr. and Mrs. David A. Kitzmiller Mr. and Mrs. Leon H. Loewenstine Sr. Mr. and Mrs. Larry T. McGruder Mr. and Mrs. Mark Moskowitz Mr. and Mrs. James Overbey Mr. John M. Isidor and Ms. Sandra P. Kaltman Mr. and Mrs. Robert M. Klare Mr. Terrence Loftus Mr. and Mrs. Thomas M. McKee Mrs. Marjorie Motch Mr. Richard A. Padgett Mr. Barry S. Klein and Ms. Dawn M. Denno Mr. and Mrs. Kevin L. Logemann Mr. and Mrs. Edward P. McNamara Mr. and Mrs. Michael S. Nelson Mr. James Page Ms. Janet Jacob Mr. Joseph Lohre Meisel Family Foundation Inc. Mrs. Jenifer Neltner Mr. and Mrs. Mark Jeanmougin Ms. Lori S. Klug Mr. and Mrs. John M. Lohrer Mr. and Mrs. Carl W. Mercurio Mr. and Mrs. Joseph B. Neville Dr. Shobana Pandian and Dr. Joseph Eapen Dr. Clinton H. Joiner and Dr. Mary E. Frederickson Mr. and Mrs. Thomas B. Koenig Dr. Jason T. Long Dr. Arnold C. Merrow Mr. and Mrs. Jerry Newell Paroz Family Foundation Mrs. Christina S. Kohnen Mr. and Mrs. Kurt Louis Mr. and Mrs. Richard G. Meyer Mr. and Mrs. Andy Newton Dr. Peter Pathrose Ms. Diane B. Jokerst Mrs. Suzanne Kopcha Mr. and Mrs. Ted M. Lucien Dr. Linda J. Michaud Mr. and Mrs. Simon C. Nielsen III Mr. Mario Patino Mr. and Mrs. Leighton Jones Mr. Mark U. Krone Ms. Tina M. Kroovand Mr. Alexander P. Miller Mr. Paul Justice Mr. and Mrs. Christopher G. Lutz Dr. Orly Ben-Yoav Nobel and Mr. Robert Nobel Mr. and Mrs. David W. Peck Mr. and Mrs. Andrew J. Junga Mr. and Mrs. James E. Lunsford Mr. and Mrs. Larry Middendorf Dr. and Mrs. Darcy A. Krueger Mr. Eric Mailloux Ms. Judith E. Miller Mr. and Mrs. Robert B. Noll Jr. Mrs. Dorothy H. Perlman Dr. and Mrs. Suhas G. Kallapur Mr. and Mrs. Joseph L. Kuhlman Dr. Geraldine M. Kaminski Mr. and Mrs. John P. Kuhr Sr. Dr. Janine C. Malone and Mr. Joseph A. Malone Mr. and Mrs. Garrett A. Kamstra Mr. and Mrs. Samir Kulkarni Dr. and Mrs. Peter B. Manning Mrs. Olga D. Kanuschak Mr. and Mrs. Daniel Kuy Mr. and Mrs. Eric M. Markus Ms. Lisa Keegan Mr. and Mrs. Andrej P. Kyselica Ms. Lisa K. Keehan Dr. and Mrs. Stephen L. Lamendola Dr. Lisa J. Martin and Mr. Chad J. Martin Mr. Thomas K. Keehan Mr. Matthew G. Lanier Mr. and Mrs. John R. Martindell Mrs. Barbara Keeling Mr. and Mrs. Brian Lawson Dr. and Mrs. Jack Matyas Ms. Lisa A. Kellar Mr. and Mrs. Daniel W. LeBlond Dr. and Mrs. Todd A. Maugans Mr. and Mrs. Jay Keller Mr. and Mrs. Guenter Lensges Mr. and Mrs. Douglas C. Maxwell Mr. Paul A. Kelly Mr. and Mrs. Lawrence A. Leser Mr. Tony Mazzone 50 Mr. and Mrs. John E. Pepper Jr. M A K IN G A DI F F ERENCE David and Nancy Wolf David and Nancy Wolf have a theory about the secret of our success, and they want to share that with children around the globe. “A special passion exists at Cincinnati Children’s,” David says. “Nancy and I have seen it in every doctor, nurse and staff member. We want doctors and researchers from across the world to experience that passion and carry it on to their patients.” Through a generous gift, the Wolfs have funded an opportunity for doctors from Israel to do just that. The David and Nancy Wolf Israel Exchange Training Program provides top medical students from Israel with the opportunity to spend time at Cincinnati Children’s learning from our world-class physicians and researchers, impacting an exponential number of doctors and patients from across the world. 51 Mr. and Mrs. Scott Sheffer Mr. and Mrs. Charles H. Taylor Mr. and Mrs. Herbert B. Weiss Dr. Sally R. Shott and Mr. Andrew M. Shott Mr. and Mrs. Michael L. Taylor Mr. and Mrs. Mark Wendling Mr. Nicholas Teegarden Ms. Mary Sue Wentzel Mr. and Mrs. Christopher R. Simon Dr. and Mrs. Roger E. Teller Mr. Barton Weprin Ms. Melody L. Siska Mr. Drew L. Smith Dr. Nathan Timm and Dr. Kimberly Daly Mr. Thomas E. Wheat and Ms. Anne E. McGrath Dr. and Mrs. Hugh C. Smith Jr. Mr. J. Raphael Tincher Ms. Katrina White Dr. Teresa A. Smolarek Mr. James N. Trumble II Mr. R. J. Solway Mr. and Mrs. William Tsacalis Mr. Roger B. White and Mrs. Marsha K. Lee-White Mr. Robert D. Sommer Mr. and Mrs. Benjamin T. Tunney Mr. and Mrs. Steven M. Wilhelm Mr. J.D. Spahn Ms. Molly Vance Mr. and Mrs. Gregory K. Williams Mr. Randal Spear Mr. and Mrs. Eric Vanderschueren Ms. Tabitha Williamson Mr. and Mrs. Brian W. Pfeiffer Mr. and Mrs. Sean D. Rice Dr. and Mrs. Michael D. Scheiber Mr. Peter Spreen Ms. Sue M. Vanney Mr. Steven R. Wilson Dr. Jannel Phillips Dr. and Mrs. Ward R. Rice Mr. and Mrs. Steven C. Schlachter Dr. Mary A. Staat Mr. and Mrs. Drew Verdecchia Mr. and Mrs. Bradley Wittenbaum Mrs. Vivian Planck Mr. Kenneth Richardson Dr. Mary W. Schley Mr. and Mrs. Kenneth W. Stecher Dr. Marty O. Visscher Dr. Yan Xu Mr. and Mrs. Sanford H. Pliskin Ms. Terri A. Roberts Mr. and Mrs. Anthony J. Schmidt Steenberg Family Foundation Mr. and Mrs. Gary Yarger Ms. Eveline A. Poe Mr. and Mrs. Stacey M. Robinson Mr. and Mrs. Bertram H. Steinhard Mr. and Mrs. Barry S. Porter Mr. and Mrs. Jack Robke Mr. Robert C. Kanter and Dr. Rosemary E. Schmidt Dr. Brian E. Volck and Dr. Jill S. Huppert Mr. and Mrs. Jerry D. Stephenson Mr. and Mrs. Joseph P. Vonderhaar Mrs. Layel Zelazny Mr. and Mrs. Donald A. Zengel Mr. and Mrs. Thomas Young Mr. Mark E. Potticary Mr. and Mrs. Robert T. Roeder Mr. and Mrs. Thomas D. Schmidt Ms. Janine Stockmeier Mr. and Mrs. Jeffery J. Waggoner Mr. and Mrs. Randy Potts Mr. and Mrs. Lawrence C. Rohling Mr. John H. Schnehain Mrs. Caroline F. Sutphin Ms. Judith A. Walsh Mr. and Mrs. James T. Ziegler Mr. J. Dale Proffitt Dr. and Mrs. Marc E. Rothenberg Mr. Eugene Schneider Mrs. Jean W. Sutphin Mr. George W. Webb Ms. Maria Zigmunt Mr. Adam Puccini Mr. Ricardo Ruiz Mrs. Joan E. Schraml Mr. Richard Sutphin Mr. and Mrs. David A. Weiper Mr. and Mrs. John R. Zimmerly Mr. Christopher Puckett Mrs. Jennifer Ruschman Ms. Margie Scruggs Dr. Mary E. Sutton Mr. and Mrs. William W. Pugh Mr. and Mrs. Craig Russell Mr. and Mrs. Robert J. Searfoss Ms. Doreen A. Quinn Mr. and Mrs. Brian M. Russell Ms. Sylvia F. Sears Mr. and Mrs. Arthur J. Raible Jr. Dr. Michael Rutter Mr. and Mrs. Marcus Sebens Mr. and Mrs. Robert B. Raines Mr. and Mrs. Robert P. Saalfeld Mr. and Mrs. Daniel F. Rechtin Mr. and Mrs. R. Daniel Sadlier Mr. Sai Shankarlingam and Mrs. Anitha T. Panchanathan Mr. and Mrs. Jason T. Saskowsky Mr. and Mrs. Manivakkam J. Shanker Mr. and Mrs. Gregory E. Reder 52 M A K IN G A DI F F ERENCE “Our family chose to help Cincinnati Children’s because it was a smart investment. They had the infrastructure in place needed to make a meaningful impact on the disease. We knew our investment would yield results.” K a r e n P h i l i p, T h e B u c k e y e F o u n d a t i o n 53 William Cooper Procter Society Ms. Anna M. Elsasser The William Cooper Procter Society recognizes and honors friends of Cincinnati Children’s who inform us that they have included the medical center in their will, estate plan or other deferred gift arrangement. Named in memory of Colonel Procter, whose visionary gift established our research endowment, this society acknowledges these generous individuals who have chosen to leave a legacy to improve children’s lives for generations to come. Mrs. Willa M. Garner Mr. and Mrs. John W. Hayden Ms. Gladys R. Elsasser Ms. Alice M. Geier Dr. and Mrs. Richard B. Heyman Mr. and Mrs. Mark G. Essig Mrs. Susanne E. Geier Mr. and Mrs. Richard L. Hildbold Mr. and Mrs. David Falk Mrs. Kathleen L. Hill Dr. and Mrs. Michael K. Farrell Dr. John A. Gennantonio and Dr. Margretta E. Gennantonio Ms. Terri J. Feie Dr. and Mrs. Roger G. Giesel Mrs. Barbara Hoekenga Mr. and Mrs. John B. Fillion Ms. Gladys R. Glassmeyer Ms. Marion R. Holthaus Mr. Michael D. Finch Mrs. Dolores S. Goldfinger Mr. and Mrs. Wallace R. Holzman Jr. Mr. and Mrs. Roy D. Hockney Dr. and Mrs. Ira A. Abrahamson Jr. Mrs. Beatrice Bluestein Mrs. Charlene F. Combs Michael and Suzette Fisher Mr. Wayne C. Gover Ms. Shawn Hooper Ms. Jean L. Abrahamson Mr. and Mrs. Donald R. Blum Mr. and Mrs. Michael A. Conner Mrs. Barbara J. Fitch Dr. and Mrs. Gregory A. Grabowski Mr. and Mrs. Terence L. Horan Mr. and Mrs. Sheldon R. Flowers Mr. and Mrs. Gaylord R. Gross Mr. and Mrs. Jason Humphreys Mr. Richard L. Hunt* Dr. and Mrs. Richard I. Abrahamson Dr. Thomas and Dr. Barbara Boat Mrs. Lois A. Cooper Dr. Ann L. Akeson Dr. Janet A. Borcherding Dr. and Mrs. Harold Fogelson Mr. and Mrs. Samuel M. Allen Mr. and Mrs. Elroy E. Bourgraf Sr. Dr. Robin T. Cotton and Ms. Cynthia M. Fitton Mr. Raymond J. Haarman Mr. and Mrs. Walter C. Frank Mr. and Mrs. Alfred P. Hallam Dr. and Mrs. Joe F. Inman Mr. Robert A. Anderle Mr. and Mrs. Harry L. Bradbury Dr. and Mrs. Alvin H. Crawford Mr. and Mrs. William A. Friedlander Mrs. Margaret H. Hamer Ms. Barbara A. Jackson Mr. James M. Anderson and Reverend Marjorie C. Anderson Mr. and Mrs. Lawrence W. Bratburd Mrs. Geraldine Crawford Mr. Robert B. Friedman Mr. and Mrs. Scott J. Hamlin Lillian M. Fritz Mrs. Marilyn H. Harra Dr. Richard L. Jackson and Dr. Judith A. Harmony Dr. and Mrs. William M. Fye Mr. and Mrs. Thomas P. Hatala Mrs. Betty K. Johnson Mrs. Mary E. Briggs Dr. and Mrs. Stephen R. Daniels Mr. and Mrs. Robert D.H. Anning Mrs. Lela C. Brown Mrs. Barbara R. DeGarmo Ms. Carole J. Arend Robert Rogan Burchenal Foundation Dr. and Mrs. Charles Deitschel Jr. Dr. and Mrs. Bruce J. Aronow Mr. Peter W. Bushelman Dr. Alexander M. Della Bella Dr. and Mrs. Richard G. Azizkhan Mr. and Mrs. Michael S. Cambron Mrs. Barbara Dellerman Dr. Diane S. Babcock Mr. and Mrs. Lee A. Carter Dr. and Mrs. Thomas G. DeWitt Dr. Earladeen D. Badger Department of Surgical Services, Cincinnati Children’s Mr. and Mrs. William O. DeWitt Jr. Division of Pediatric Otolaryngology, Cincinnati Children’s Ms. Lynne Downs Dr. Francis M. Biro and Ms. Nancy L. Bloemer Dr. Douglas F. Clapp Mr. and Mrs. Todd M. Duncan Mr. and Mrs. James W. Cochran Ms. Donna S. Eby David D. Black* Mr. and Mrs. Thomas G. Cody Sr. Dr. and Mrs. Franklin J. Edge Mr. and Mrs. Thomas C. Blinn Mr. Reed L. Coen Mrs. Joan T. Ehas Mrs. Elaine H. Baverman* Dr. and Mrs. Corning Benton Mr. and Mrs. Ronald W. Beshear 54 Ms. Audrey J. Dick Ms. Jane R. Dummer M A K IN G A DI F F ERENCE Tom and Mary Ellen Cody “Anything you can do to get involved with Cincinnati Children’s is a privilege,” says Tom Cody, chairman of the Cincinnati Children’s Board of Trustees. In addition to his institutional leadership, Tom and his wife Mary Ellen are passionate philanthropists who are leading by example through their generous support of the Heart Institute. The institutes at Cincinnati Children’s are grounded on three mainstays–clinical care, research and education. The Codys’ gift will impact all three. In addition to supporting continuing education for the institute’s pediatric cardiac specialists, it will also expand the Ventricular Assist Device (VAD) Program. VADs are mechanical pumps used to keep patients alive while they wait for heart transplants, and they are also being studied as a treatment to repair cardiac muscle damage, reducing the number of patients needing heart transplants. 55 Mr. and Mrs. Patrick O’Brien Ms. Arlene J. Sansone Ms. Michelle B. Starkey Mrs. Mildred A. Jones Dr. Harold K. Marder and Dr. Jewel D. Slesnick Mr. and Mrs. Richard H. Okenfuss Mr. and Mrs. Robert B. Sathe Dr. James F. Steiner Drs. Brad W. Warner and Barbara B. Warner Ms. Margaret H. Jung Ms. Marie A. Marley Dr. Sonya G. Oppenheimer Ms. Donna L. Schiff Mrs. Mary S. Stern Dr. Richard B. Warriner III Dr. Mark A. Kahn Dr. and Mrs. James M. Marrs Mr. Maurice E. Oshry Dr. and Mrs. Robert C. Schiff Jr. Dr. and Mrs. Richard J. Stevenson Mr. and Mrs. Todd Washburn Mrs. Olga D. Kanuschak Dr. and Mrs. Lester W. Martin Mr. Bruce A. Pavlech Mrs. Nancy L. Schlemmer Mr. and Mrs. Charles N. Stix Mr. Dustin J. Waters Mrs. Molly E. Kaplan* Mr. Manuel D. Mayerson* Mr. and Mrs. Charles H. Pease Mr. and Mrs. Robert F. Schmidt Ms. Kathleen J. Stotler Mr. and Mrs. Barry S. Weinstein Mrs. Marie C. Katzenstein Mrs. Rhoda Mayerson Mr. and Mrs. Kroger Pettengill Mr. and Mrs. Dale L. McGirr Dr. Steven M. Pilipovich Dr. C. Frederic Strife and Dr. Janet L. Strife Mr. Harvey M. Weitkamp Dr. and Mrs. Emanuel Kauder Mr. Robert C. Kanter and Dr. Rosemary E. Schmidt Dr. and Mrs. Thomas R. Welch Mr. Aloysius F. Keller Mr. and Mrs. Michael S. McGraw Mr. and Mrs. Geoffrey Place Ms. C. Jean Schroer Dr. and Mrs. David M. Sullivan Mr. and Mrs. Robert Wert Dr. and Mrs. Thomas R. Kimball Dr. and Mrs. Robert L. McLaurin Mr. and Mrs. John J. Planes Jr. Dr.* and Mrs. William K. Schubert Mr. G. Richard Thomas Dr. Clark D. West Mr. Allen J. King Dr. J. Scott McMurray Mr. and Mrs. Robert B. Raines Mr. and Mrs. Phil F. Schultz Mr. James L. Thompson Mrs. Patricia P. Whitaker Ms. Patricia Kisker* Jeanette L. Meier Dr. and Mrs. Joseph L. Rauh Dr. William J. Scott Jr. Mr. and Mrs. Paul H. Tobias Dr. and Mrs. Jeffrey A. Whitsett Mrs. Margaret W. Kite Dr. and Mrs. C. Nelson Melampy Mr. and Mrs. Louis Rauh Kenneth and Lois Sears Dr. Joseph C. Todd Dr. and Mrs. J. Paul Willging Mr. and Mrs. Ronald A. Koetters Dr. Mary P. Melvin* Dr. and Mrs. Stephen M. Rauh Mr. and Mrs. David B. Sharrock Dr. and Mrs. Thomas U. Todd Dr. and Mrs. Gordon W. Womack Mrs. Gladys M. Kurtz Reverend and Mrs. Roger L. Meredith Dr. and Mrs. J. Mark Reed Dr. and Mrs. Curtis A. Sheldon Mr. Leonard C. Tolliver Jr. Mrs. Jean E. Wommack Dr. Beatrice C. Lampkin Dr. and Mrs. Richard A. Meyer Dr. and Mrs. David M. Rider Mrs. Kathleen A. Sherlock Dr. and Mrs. Randolph T. Travis Mrs. Joan R. Wood Dr. and Mrs. Robert J. Lerer Mrs. Frances M. Miller Reverend Mr. Luis O. Riva Saleta Mr. and Mrs. Ronald E. Vankalker Mr. and Mrs. Robert C. Woodiwiss Dr. and Mrs. James L. Lessard Mr. John N. Miller Mrs. Marjorie B. Robbins Mr. Andrew M. Shott and Dr. Sally R. Shott Dr. and Mrs. Jeffrey J. Wacksman Dr. and Mrs. Frank C. Woodside III Dr. and Mrs. Jeffrey Robbins Ms. Miriam R. Siegel Ms. Saundra E. Walker Ms. Lynne T. Wu Dr. Anthony J. Mortelliti and Dr. Gisella Mortelliti Mr. and Mrs. Gerald J. Robinson Dr. and Mrs. Hugh C. Smith Jr. Mr. Thomas A. Long* and Dr. Ann R. Gelke Mrs. Marjorie Motch Ms. Andrea T. Rosenthal Carl J. Mueller* Mrs. Ruth F. Rosevear Dr. John R. Liu and Ms. Kari A. Jodal Ruth M. Mueller Dr. Robert R. Ross Dr. Jennifer M. Loggie Dr. and Mrs. Charles M. Myer III Mr. and Mrs. Snowden M. Rowe Mr. George B. Lott and Ms. Barbara N. Wurth Mrs. Gayle R. Nesselhuf Mr. and Mrs. Michael P. Russell Mr. and Mrs. Joel L. Newberg Mr. and Mrs. Ronald W. Lyons Estate of Lucile H. Ryan Mr. and Mrs. Hale Newman Mr. and Mrs. Millard H. Mack Mr. Paul L. Niklas Dr. Frederick C. and Mrs. Susan H. Ryckman Ms. Lyn M. Jones Dr. Joseph E. Levinson and Dr. Sophia M. Levinson Dr. and Mrs. Philip K. Lichtenstein Ms. Judith E. Miller 56 Mrs. Phyllis M. Romanow Mr. and Mrs. John P. Zanotti Estates and Trusts Corporations, Foundations and Other Nonprofits Throughout our history, Cincinnati Children’s has benefited from thoughtful friends who have provided for the future needs of the medical center. With grateful appreciation, we honor the memory of these donors who provided a gift during the past year through their estate plan. Businesses, foundations and nonprofit organizations–both large and small–partner with Cincinnati Children’s in our important work. Their generous support of our mission plays a vital role in advancing care for patients and families, while strengthening and enriching our community. Rose M. Albrecht Trust Estate of Jackie Kasten Estate of Marie A. Reichel $1,000,000 + $100,000 – $249,999 Bill and Melinda Gates Foundation Doris M. Akeson Ida C. Kayser Trust Carolyn Rueppel The Convalescent Hospital for Children American Liver Foundation Histiocytosis Association of America William Belmont Backs and Louise Nuxoll-Backs Trust Dorothy M. M. Kersten Trust Estate of Lucile H. Ryan American Thoracic Society Hope on Wheels Hyundai Dealers Estate of Richard C. and Jean Kinstler Estate of Leroy E. Schilling Cystic Fibrosis Foundation (National Headquarters) Angels for Eosinophilic Research Alliance Josh Cares Katherine E. Cooke Trust Estate of Donald J. Moeggenberg Michael M. Shoemaker Trust Division of Emergency Medicine, Cincinnati Children’s The Edward and Edna Frances T. Everlien Charitable Trust Marion H. Morrison Trust J. Frederick and Helen B. Vogel Trust Fondation Leducq Children’s Digestive Health Nutrition Foundation Estate of Mildred J. Walters March of Dimes Foundation The Children’s Heart Association Louise A. Williams Trust The Perinatal Institute Children’s Heart Foundation Lupus Foundation of America Inc. Bernal R. Woodward Trust Toyota Motor North America Inc. Children’s Miracle Network Hospitals $500,000 – $999,999 Cincinnati Center for Developmental Disorders Foundation The H.B., E.W., and F.R. Luther Charitable Foundation, Fifth Third Bank and Narley L. Haley, Co-Trustees Mary S. Belville Trust Estate of Joseph W. Heideman, Jr. Juliet C. Muller Helmsworth Trust Estate of Richard L. Hunt Otto Luedeking Trust Dorothy T. Mueller Trust Mandyam Dhati Narayan Trust Betty H. Palmer Charitable Lead Trust Charles W. Scott Trust American Heart Association Inc. The Sontag Foundation St. Baldrick’s Foundation The Cure Starts Now Foundation Division of Pediatric and Adolescent Gynecology, Cincinnati Children’s The Sidney Kimmel Foundation for Cancer Research Kohl’s Department Stores Leukemia Research Foundation Macy’s Department Stores Matching Gifts Masimo Foundation Helen G., Henry F. & Louise Tuechter Dornette Foundation, Fifth Third Bank, Trustee The Ohio National Foundation Fifth Third Bank John A. Schroth Family Charitable Trust Food Allergy Initiative Speedway LLC Crohn’s & Colitis Foundation of America Fosdick & Hilmer Inc. The V Foundation for Cancer Research Orthopaedic Research & Education Foundation Foundation for Anesthesia Education and Research Walmart Foundation $250,000 – $499,999 Autism Speaks Burroughs Wellcome Fund CancerFree KIDS Pediatric Cancer Research 59 The Procter & Gamble Fund Marge & Charles J. Schott Foundation Macy’s Inc. Dairy Queen Corporation TriVersity Construction Markey Cancer Foundation Bear Necessities Pediatric Cancer Foundation Medtronic Foundation Children’s Cancer Research Fund Messer Construction Company Dental Care Foundation, Cincinnati Children’s Truist Max’s Blue Butterfly Anonymous National Tuberous Sclerosis Association Cincinnati Bell Technology Solutions Muscular Dystrophy Association Inc. Endocrine Fellows Foundation Wound Healing Society Foundation Aplastic Anemia & MDS International Foundation Ohio Cancer Research Associates Dikla Insurance Company Ltd. The PNC Financial Services Group Epic Systems Corporation The PNC Foundation Ethicon Endo-Surgery Inc. The Nelson Stark Company The Childhood Brain Tumor Foundation Society of Cardiovascular Anesthesiologists Foundation Fort Washington Investment Advisors Inc. Taft Stettinius & Hollister LLP Gabrielle’s Angel Foundation for Cancer Research GE Aviation Cystic Fibrosis Foundation Therapeutics Inc. THP Limited Inc. Tourette Syndrome Association GBBN Architects Thrasher Research Fund The Gerber Foundation UCB Inc. General Electric Evendale Employees’ Community Service Fund Western & Southern Financial Group Masters The Gorilla Glue Company $50,000 – $99,999 Robert Wood Johnson Foundation American Lung Association (Headquarters) Charles H. Dater Foundation Fifth Third Asset Management Inc. The Hartmann-Ryan Team at Cassidy Turley Victory Wholesale General Electric Foundation Matching Gifts $25,000 – $49,999 Insuring The Children American College of Rheumatology Research & Education International OCD Foundation Auction to Benefit Project SEARCH HORAN Howard Hughes Medical Institute Johnson Investment Counsel Inc. $10,000 – $24,999 American Academy of Allergy, Asthma & Immunology American Academy of Pediatrics American Endowment Foundation American Financial Group Inc. M A K IN G A DI F F ERENCE Wa l m a rt / S a m ’ s C l u b When corporations and communities come together, miracles can happen. Cincinnati-area Walmart and Sam’s Club customers and employees rallied during the Children’s Miracle Network Hospitals’ Miracle Balloon Campaign benefiting Cincinnati Children’s. This year’s campaign was one of the most successful ever, more than doubling last year’s contribution. Club family,” says regional manager David Gose. “Our customers and associates are parents, aunts and uncles, brothers and sisters and of course, grandparents. When we see children who need medical care, we want to make a difference. The Miracle Balloon Campaign provided an opportunity for our customers and associates to give whatever they could afford to children who need the level of care that Cincinnati Children’s provides, and they gave without hesitation.” “The children treated at Cincinnati Children’s hold a special place in the hearts of the Walmart and Sam’s 60 American Society for Surgery of the Hand Anonymous Carpet Cushions & Supplies Inc. Cincinnati Bell Inc. Cincinnati Music and Wellness Coalition CinRon Marketing Group LLC Cisco Systems Inc. Citizens United for Research in Epilepsy Costco Wholesale-Springdale Healthnetwork Foundation Huron Consulting Group Inc. Interim HealthCare of Cincinnati Inc. International House of Pancakes The Frank J. Kloenne and Jacqueline D. Kloenne Foundation Turner Construction Company $5,000 – $9,999 AFLAC AHRA Education Foundation The Archiable Electric Company Bahl & Gaynor Investment Counsel Inc. Butler County Medical Center LLC The Cambridge Charitable Foundation Chase Bank Children’s Tumor Foundation Circle K Midwest Clover Hill Farm Inc. Leukemia & Lymphoma Society The Columbus Foundation R.G. McGraw Insurance Agency Inc. Corporex Companies Inc. National Hemophilia Foundation Cotswold Foundation Al. Neyer Inc. CSL Behring LLC NISH National Office Operating Account Deloitte Ohio Casualty Foundation Duke Energy Foundation Ohio Credit Union League dunnhumbyUSA Omnicare Inc. Foxx Construction LLC The Peck Hannaford & Briggs Co. Frost Brown Todd LLC Plastic Surgery Foundation Genesys Telecommunications Laboratories Inc. RCF Group Tackling TS Charity 61 DiaPharma Group Inc. Give with Liberty Matching Gifts Program GKN Aerospace Cincinnati Time Warner Cable Dell Inc. Palo Alto Networks Inc. Great Clips Inc. The Union Central Life Insurance Company Delta Community Credit Union The Highfield Foundation EMC Corporation The Procter & Gamble Company Shareholder Services J.P. Morgan Chase & Co. United Way of Greater Cincinnati Five Guys Burger and Fries Ransohoff Inc. Katz, Teller, Brant & Hild Valvoline Instant Oil Change General Electric United Way Campaign Ruttle Design Group Inc. Kicks for Kids WLWT Genzyme Corporation SGC Foundation Lundbeck Inc. Wright Brothers Inc. GR/AD Architects Smile Train Graydon Head & Ritchey LLP M&T Investment Group Marriott Foundation For People With Disabilities Marriott International Joanna McAfee Childhood Cancer Foundation Miles That Matter Foundation Olivia J. Murray Foundation MV Commercial Construction LLC Nativity The Pop Opera PEDCO E & A Services Inc. Pension Corporation of America PNC Bank Pomeroy RE/MAX Regional ServicesAlpharetta, GA Sigma Theta Tau International Honor Society of Nursing $2,500 – $4,999 3D Exhibits Ace Hardware Foundation American College of Radiology Avaya Inc. Baker Concrete Construction Bank of America Bank of America Matching Gifts Bayer Becker / Terracon Beth Israel Deaconess Medical Center Brenco Inc. Building Blocks Foundation Clever Crazes for Kids CBCE cHc Manufacturing Inc. Chico’s FAS Inc. Cintas Corporation Society for Pediatric Dermatology CO-OP Financial Services Sodexo CTS Telecommunications Strauss & Troy Curtis Inc. Thompson Hine LLP DeBra-Kuempel Han’s White Tiger Tae Kwon Do Anthony D. Castelli, Attorney at Law Harmony Staffing Services LLC Department of Accounting, Cincinnati Children’s Healthcare Regional Marketing Department of Home Care Pharmacy, Cincinnati Children’s Human Arc Corporation Jack Dym Investment LTD. The Success Group LTD. Division of Infectious Diseases, Cincinnati Children’s The Health Foundation of Greater Cincinnati United Group Services Inc. Champion Window Mfg. & Supply Maxwell C. Weaver Foundation Cincinnati Wholesale Ice Cream Inc. Hispanics Avanzando Hispanics The Wilbert Foundation Cochlear Americas Human Genetic Therapies Inc. Zanett Commercial Solutions Inc. Controlled Credit Corp. Huntington Bank Zeus Sports Inc. CREW Greater Cincinnati J. II Fire Systems Inc. Kenneth Wong Corporation KeyBank KLH Engineers Inc. Kolar Design Lone Star Steakhouse & Saloon Lone Star Steakhouse-Middletown Loth, Inc./IWS The Lubrizol Foundation Luckenbach Lines Inc. Macy’s Foundation Meijer Netscout Novartis International AG OMNOVA Solutions Foundation ORACLE 62 Cafco Custom Glass & Glazing Inc. $1,000 – $2,499 The 100 Times Foundation Corporation Cystic Fibrosis Foundation Pharmacy LLC W. Ron Adams P.S.C. Dinsmore & Shohl LLP Akers Packaging Services Inc. Economy Linen & Towel Service American Lung Association of the Midland States Every Child Succeeds American Scaffolding Inc. Arthritis Foundation BHDP Architecture Bowling Green Pediatric Dental Group Findlow Filtration Inc. Fink Foundation FirstGroup America Gas America Charitable Foundation BP Fabric of America Fund The Patrick and Amanda Gavin Charitable Foundation Brooks Brothers Group Inc. The Greater Cincinnati Foundation Bruegger’s Enterprises Inc. Green Crest Golf Course Buffalo Wild Wings H & R Block Financial Advisors Inc. Butler Technology and Career Development School Carol and Ralph V. Haile Jr., U.S. Bank Foundation 63 Hub Pen Company Inc. IBM Employee Services Center Johnstone Supply/Controls Center Inc. Just Give Kao Brands Company Keating, Muething & Klekamp PLL Kessler Foundation Key Foundation Matching Gifts Kroger Company LPK Martin & West PLLC McCarthy Strategic Solutions Med Assets Med-El Corporation Merrill Lynch Matching Gift Program Mid-American Junior Golf Tour Middletown Community Foundation Mike-Sells Potato Chips New York Life Insurance Co-Cincinnati Neyer Properties Inc. Northrop Grumman Corporation Nutricia North America Océ North America, Inc. Matching Gifts Program Office Depot Regional Office Total Quality Logistics Carrigan and Grimm Inc. Ohio Legislative Black Caucus Foundation Traction LLC Traincroft Inc. Department of Home Health Care, Cincinnati Children’s Ohio Physical Therapy Association US Bank Omega Processing Solutions LLC On Line Design Inc. Oticon Inc. Phonak Corporation Pitcher, Enders & Drohan CPA’s Inc. Planes Moving & Storage Inc. Pratt Corrugated Holdings Inc. Prestige Technical Services Inc. Pride Technologies Progressive Podiatry LLC Radisson Hotel Cincinnati Riverfront Remke bigg’s August A. Rendigs, Jr. Foundation Rite Aid Corporation Sinai Hospital Scripps Financial Service Center See Kids Dream Semler Industries Inc. Sharefax Credit Union Inc. Sheldon-Reder Suburban Real Estate Corporation Superior Honda Teri Studios TGW International Inc. Thunder11 Illinois Tool Works Foundation Matching Gifts Niscayah Inc. Standex Electronics Inc. Northwestern Mutual-West Chester Steiner Electric Company NxTech, Incorporated Stiles Associates Chemed Foundation Information & General Services MBA Chapter OK Interiors Corporation Tactical Advantage Group LLC Vorys, Sater, Seymour and Pease LLP Cheviot Savings Bank International Traders Inc. Dennis Ott Builders Inc. Ashley Ward Inc. Chick-fil-A P L Marketing Inc. U.S. Bancorp Matching Gift Foundation Widmer’s Cleaners CINFAB, LLC JPMorgan Chase Matching Gifts Program ComDoc JTM Provisions Co. Inc CTL Engineering Inc. Ben Kelhoffer Foundation Inc. Custom Fabricators Inc. Kenwood Dealer Group Inc. Parkside Nursing and Rehabilitation Center Customer Relationship Metrics LaRosa’s Pizzerias Passport Health Communications Inc. Vanguard Charitable Endowment Program Cutting Edge Services Corporation LexisNexis Performance Honda Vitronic Promotional Group Doner Financial Inc. LifeCenter Organ Donor Network Perry Interiors Inc. W E L Ventures Inc. Duke Energy Matching Gifts Program Lindhorst & Dreidame Company Pfizer Inc. Waltz Business Solutions Duke Energy-Zimmer Generation Station Logistics and Procurement Services LLC Pinnacle Environmental Consultants Inc. Market Precision Inc Reed Medical INC. Warren County Records Center & Archives Duke Realty Corporation Maxor National Pharmacy Service Corp. REinvest Consultants Ernst & Young Foundation McLane Food Service Inc. #153 RespirTech Express Employment Professionals Inc. Medco Employee Giving Campaign SALIX Figure Weight Loss Miltenyi Biotec Inc. SEI-Cincinnati LLC Food Lion MMG Corporate Communication Inc. Spina Bifida Association of Cincinnati Gannett Foundation Matching Gifts M-Pact Corporation Genentech Inc. The Carter Nedley Foundation SpringHill Suites by Marriott-Waterstone $500 – $999 AAkron Rule Corp. Advanced Bionics Advanced Health Media LLC Alternative Design American Cold Storage Systems Inc. American Cornhole LLC Anonymous (2) Aptalis Pharma US Inc. Arts Rental Equipment Inc. Baule USA LLC Baxter Healthcare Corporation Besse Medical Associates R. P. Biederman Co. Inc. Boutique 280 Bow Automation Bretagne, LLC Kentucky Account Brower Insurance Agency Incorporated Tim Browne Memorial Inc. The Bungie Foundation CAI Insurance Agency Inc. 64 The Pampered Chef Paragon Financial Group United Cerebral Palsy of Greater Cincinnati Inc. United Way of Greater Stark County Western & Southern Life Insurance Company WKRC-TV Women’s Plastic Surgery Centre WRP Associates LLC XL Insurance Group YPO Forum X Gilead Sciences Inc. Greystone Investments Management Hahana Beach Handy Window Shade Inc. Healthlinx Executive Search Inc. Hill-Rom Holdings Inc. M A K IN G A DI F F ERENCE “When we see children who need medical care, we think of their families and we want to work with Cincinnati Children’s to make a difference.” D av i d G o s e , Wa l m a rt / S a m ’ s C l u b 65 Chairs and Fellowships We are grateful to the individuals, families, corporations and foundations that had the vision to establish permanent endowment accounts to benefit the children and families we serve. Their investment in the future of the medical center provides ongoing support for salaries, equipment and laboratory costs that are necessary to create new knowledge to advance and improve child health. The Beatrice C. Lampkin Chair of Pediatric Hematology/Oncology The George Rieveschl, Jr., Chair in Research The Division of Pediatric Surgery Research Chair The Joseph E. Levinson Chair of Pediatric Rheumatology The Jeff Robbins Chair The Katherine Stewart Waters Chair of Experimental Hematology and Cancer Biology The Luther Foundation Research Chair of Pediatric Pulmonary Medicine The Alvin H. Crawford Chair of Pediatric Spine Surgery The Marjory J. Johnson Chair of Pediatric Hematology/Oncology The Robert L. Creedon Chair of Pediatric Dentistry The Marjory J. Johnson Chair of Brain Tumor Translational Research The Division of Critical Care Medicine Chair The Marjory J. Johnson Chair of Vascular Tumor Translational Research The EMSC Chair of Pediatric ER Medicine The Neil D. Johnson Chair of Radiology Informatics The Gunnar Esiason/Cincinnati Bell Chair of Life Sciences Research The Rob and Jessican Kahn Chair of General and Community Pediatrics The James M. Ewell Chair of Pediatric Research The Samuel and Molly Kaplan Chair of Pediatric Cardiology The David G. and Priscilla R. Gamble Chair of Neonatology The Dorothy M.M. Kersten Chair of Pediatric Gastroenterology The Division of Pediatric Gastroenterology Chair The Kindervelt Chair of Pediatric Pulmonary Biology The Lee Ault Carter Chair of Pediatric Ethics The Emma Margaret and Irving Goldman Chair of Pediatric Ophthalmology The Deb Kleisinger Chair of Novel Cancer Treatment The Robin T. Cotton Research Chair of Pediatric Otolaryngology The David N. Glass Chair of Pediatric Rheumatology The Alvin H. Crawford Chair of Pediatric Orthopaedic Surgery The Carolyn Hamlin Chair of Otology Research Chairs The Division of Allergy and Immunology Chair The Richard and Geralyn Azizkhan Chair of Pediatric Surgery The William F. and Rebecca A. Balistreri Chair of Pediatric Hepatology The William S. Ball Chair of Radiology Research The Corning Benton Chair of Radiology Education The Thomas Boat Chair of Pulmonary Medicine The Kevin E. Bove Chair of Pediatric Pathology The Hubert and Dorothy Campbell Chair of Pediatric Pulmonology 66 The Othilda Krug Chair of Child Psychiatry The Beatrice C. Lampkin Chair of Cancer Biology The Lester W. Martin Chair of Pediatric Surgery The Robert and Sarah McLaurin Chair of Pediatric Neurosurgery Research The C. Nelson Melampy Chair of Pediatric Anesthesiology The A. Graeme Mitchell Chair of Human Genetics The M. Susan Moyer Chair of Pediatric Inflammatory Bowel Disease The Robert Myers and Mary Colgate Shoemaker Chair of Pediatric Endocrinology The Sonya Oppenheimer Chair of Developmental and Behavioral Pediatrics The Division of Pathology Chair The Aaron W. Perlman Chair of Pediatric Rehabilitative Medicine The B.K. Rachford Chair of Pediatrics The Louise W. and Joseph L. Rauh Chair of Adolescent Medicine The Pauline and Lawson Reed Chair of Pediatric Infectious Diseases The Thelma and Jack Rubinstein Chair of Pediatric Developmental Disorders and Mental Retardation The Richard Ruddy and Barbara Wriston-Ruddy Chair of Pediatric Emergency Medicine Research The Frederick C. Ryckman Chair of Pediatric Surgery The Albert B. Sabin Chair of Pediatric Infectious Diseases The Schlemmer Family Chair of Pediatric Research The Jacob G. Schmidlapp Chair of Pediatric Hematology/Oncology The William K. Schubert Chair of Pediatric Research The Curtis Sheldon and Jeffrey Wacksman Chair of Pediatric Urology The Frederic and Carolyn Silverman Chair of Pediatric Radiology The Charles H. Sloan Sr., Olive Louise Sloan, and Charles H. Sloan Jr. Chair of General Pediatric Research The StarShine Chair The Janet L. Strife Chair of Radiology Quality and Safety The Ralph J. Stolle Chair of Pediatric Immunology 67 The Transplant Hepatology Chair The Carl Weihl Chair of General and Community Pediatrics The Clark D. West Chair of Pediatric Nephrology The Louise M. Williams Chair of Pediatric Nephrology F e l l o ws h i ps The William George Bauer Fellowship in Pediatric Hematology/Oncology The Mary Louise Burton Fellowship in Pediatric Gastroenterology The Ruth Knittel Dietz Perinatal Research Institute Fellowship The Katharine S. and Gerald J. Ficks Fellowship in Neonatology The Andrew Jergens Foundation Fellowship in Pediatric Endocrinology The Junior Co-Operative Society Fellowship in Pediatric Diabetes The Junior Co-Operative Society Fellowship in Pediatric Infectious Diseases The Ida C. Kayser Fellowship in Pediatric Pulmonology The Edward L. Pratt Fellowship in Pediatric Medicine and Nutrition The Reginald C. Tsang Fellowship in Neonatology and Pulmonary Biology The Edward F. Scully Fellowship in Pediatric Endocrinology The Josef F. Warkany Fellowship in Human Genetics The Frank C. Woodside and Dinsmore & Shohl Fellowship in Epidemiology and Biostatistics Tribute Gifts When donors make a gift in honor or memory of a loved one, our patients benefit from their generosity. We thank the families and friends of the following individuals, who have had $500 or more donated in their name. Mr. Joshua C. Mack Timothy Browne Andrew J. Hagen Kurtis Martin Raymond Buse III Christopher Harmon Dr. and Mrs. Robert L. McLaurin Paul Carroll Kaylynn M. Hartman Mr. Nick Moloney Dalton Chandler Joyce Heiman Mr. and Mrs. Jeffrey Northern Arun Chatterjee Zachary Heringer Ms. Priscilla Peyton Manuel Chavez Sr. Mary Hess Ms. Cameron Rawlings Steven A. Cirino II Mr. Anthony G. Hoel Dr. Pramod P. Reddy and Dr. Usha P. Reddy Jennifer K. Clanton Kyle T. House Phyllis Clyde Anabelle Huff Mr. Seth Rogers Bruce W. Cochran Alice Humbert Ms. Lynn W. Roy Sophia Cordier Elizabeth M. Igel Ms. Julien R. Guttman Joyce W. Coykendall Gregg Jacob Dr. and Mrs. Richard G. Azizkhan Dr. Mitchell B. Cohen and Dr. Morissa Cohen Brayden Schindler Dr. Nancy Hagerman Mrs. Catherine A. Schneider Hunter A. Creech Judith Johnson Mr. Lynwood L. Battle Jr. Ms. Maya Collins Ms. Sylvia Heiby Ms. Sara Shinn Mary Christine Daush Richard E. Kaeser Jamie Benassi Mr. Louis Costello Bailey A. Hemingway Mr. Reese Stuart Mrs. Shirley I. Davies Jenna Kamphaus Mr. Jake Bertellotti Dr. and Mrs. Kerry R. Crone Ms. Casey Hilmer Grace Tapp Rowan Dinn Joseph Kanuschak Mr. Pierce J. Blalock Carter John Davis Mr. Jacob T. Hoffman Dr. Ann Weichert Dr. Harold Downing John B. Kara Cameron I. Bordainick Colin Davis Ms. Kai N. Hollingsworth Dr. Brenda Wong Amanda M. Drake Ben Kelhoffer Mr. Matthew K. Bormet Mr. Shane P. DiGiovanna Mrs. Kristin Horsburgh Patricia Droppelman-Helton Hayes R. Kelley Mr. and Mrs. Elroy E. Bourgraf Sr. Tanner Dole Richard C. Kinstler Mr. and Mrs. William C. Bredenfoerder Mr. Frank Wray and Ms. Kathleen M. Kool-Wray Emily Dubois Nicholas Dworjanyn Deborah L. Folker Matthew Korfhagen Nathaniel Brown Master Manish Eapen Ms. Katherine Koslovsky Curtis G. Buerkett Mr. Ryan Elliot Dr. Helen Kranbuhl Master Michael Buerkett Ms. Elsa Fagin Mr. and Mrs. Venu G. Krishnamoorthy Brady Campbell Ms. Marie Fern Dr. and Mrs. Daniel I. Choo Mr. Michael A. Fisher Mr. Jonathan J. Calderas and Dr. Corinne Lehmann Jonah Chuang Dr. David N. Franz Ms. Kathryn Leikhim Mr. and Mrs. Thomas G. Cody Sr. Ms. Ava M. Gallino Dr. and Mrs. Marc A. Levitt Ms. Ashley Gavin Ms. Lauren Lloyd I n H o n o r Of 68 I n M e m o r y Of Erik Anderson Rebecca Archambeault Regan Leigh Arnold Henrietta F. Belmont Michael Blessinger Lora Bodley Norbert Borgman Natalie Bost Emily M. Brehm Gerardo (Jerry) Brindisi Ayelet Y. Galena Wright Lanier Julia Gallino Jenna C. Laumer Clifton Kippy Gideon Andrew Lee Judith E. Gilliam Michael Little Caroline Goebel Thomas A. Long Kim Goebel Eleanor S. Lortz Joseph M. Gruber Patricia E. Macke Florence Guttman Manuel D. Mayerson 69 Auxiliaries J u n i o r C o - Op e r a t i v e S o c i e t y G i ft : Established in 1910, the Junior Co-Operative Society operates and staffs the Gift Shops at Cincinnati Children’s Burnet and Liberty campuses. The Gift Shops are filled with a wonderful selection of toys, games, cards and books to lift the spirits of hospitalized children. All proceeds from the Gift Shops are donated to the medical center. Their dedicated volunteers live by their motto, “the more you shop, the more we give.” K i n d e r v e lt C i t y P r e s i d e n t: G i ft : Shelia McCuddy Dr. Jack H. Rubinstein Joe Stima Sophie Meinhardt Michael Salt Abby Lyn Streszoff Patrick & Drew Meisenheimer Mitchell W. Sayre Robert Taylor Jr. Tony R. Merk Robert F. Schapker Marjorie Timko William J. Meyer Francis J. Scharon Michael C. Torbeck Kyle Miller Holly Schmitz Samuel George Towne Mary Susan Moyer Jonathan P. Schmitz Faith Venerable Ms. Janie Newton Dr. William K. Schubert Mason Ward Kurt A. Ostling Paul D. Seiter Michael T. Washburn Norman Oxley Luke Seitz Lillian Wesner Dr. Aaron W. Perlman George Shelby Molly West Crystal G. Phillips Kathleen A. Sinkula Ronald West Ian Pierce Sophia Jane Smallwood William Whitsett Bhama Rajaram Kortney Snyder Ryan Wilson Puli Pradip Reddy Russell Dale Stephenson Sarah E. Zoz 70 Marjorie Gilsdorf $482,832 P r e s i d e n t: United by a common interest in supporting the medical center, Cincinnati Children’s auxiliaries have been essential to our success. If you would like more information about our auxiliaries, or if you wish to join in their important work, please call 513-636-6080. Buffie Rixey $575,550 Ass o c i a t i o n o f V o l u n t e e r s Our largest fundraising auxiliary, Kindervelt is widely recognized as one of Greater Cincinnati’s outstanding volunteer organizations. With nearly 1,000 members in groups around the region, linked by a citywide board of trustees, Kindervelt truly lives its mission to “have fun while raising funds” for the patients and families of Cincinnati Children’s. In its more than 40-year history, the women of Kindervelt have contributed over $15 million to the medical center. Jeane Elliott $60,300 P r e s i d e n t: G i ft : The Association of Volunteers has supported the Convalescent Hospital for Children, an affiliate of Cincinnati Children’s, for more than 40 years. To raise funds for the Convalescent Hospital, the association sponsors the Cincinnati Art & Antiques Festival. This four-day antique show, held each October, is one of the largest and finest in the country. T h e C o o p e r a t i v e S o c i e t y Nancy Sorg $761,600 P r e s i d e n t: F u n n y C o mp a n i e C l o w n s G i ft : P r e s i d e n t: G i ft : Our first auxiliary, the Cooperative Society has served Cincinnati Children’s for more than 125 years. In addition to financial contributions, members of the Cooperative Society also give generously of their time. Members volunteer for the Division of Child Life and Recreational Therapy, the Mayerson Center for Safe and Healthy Children and the sewing room. Donald Bachmann $13,160 Since 1983, the Funny Companie Clowns have been delighting children and adults throughout the community, while raising money for Cincinnati Children’s. The 25member volunteer auxiliary performs at holiday parties, company picnics, birthday parties and festivals, and has raised nearly $200,000 for the medical center. 71 Special Events and Community Organizations American Board of Internal Medicine B2B Halloween BashFamilies Against Brain Injury Kiwanis Club of Kenwood-SilvertonMadeira Golf Outing Brenco Golf Outing Chipping In for Children Happy Hour Leis for Sheriff Committee Chippin’ in for Children CJCC Volleyball Tournament A Night In For Neuroblastoma SGC Foundation Golf Outing Cincinnati Friends of Charity Olde Sawmill Elementary Torch Relay Cincinnati Marathon, Inc. Our Lady of Lourdes School Toys for Nicholas Cincy Kids 4 Kids Primrose School of West Chester Becca’s 2nd Annual Legendary Run for the Cure Turpin Parents Soccer Club John R. Estep Charity Golf Outing R.C. Hinsdale School Xavier University Charity Golf Outing Families Against Brain Injury Xavier University Dance Marathon Abby Glaser’s Family Talent Show Fundraiser Rocks Football Team 7th and 8th Grade Car Wash Special events bring people together to benefit our young patients, while building awareness of the medical center and children’s health issues. Cincinnati Children’s thanks each and every volunteer and supporter who gave time, talent and resources for an event that benefited the medical center. Those events that raised $500 or more are listed here. $500,000 + Katie Linz Foundation Cincinnati Walks for Kids The Plaid Open Celestial Ball Sample, Savor and Support Liam Nolen Bradley Memorial Tennis Masters Series Fairlawn Local School Warrior Run: The Race For Life Ellen B. Ganson Memorial Foundation $250,000 – $499,999 An Evening to Honor Milt Kantor $100,000 – $249,999 Angels for Eosinophilic Research Golf Tournament Ruth Lyons Children’s Fund $10,000 – $24,999 Champions Fore Cincinnati Children’s Golf Outing Funny Companie Clowns Hearts are Trump Euchre Tournament $50,000 – $99,999 LEGO KidsFest Annual Golf Outing Benefiting the Center for Infants and Children with Special Needs Neurosurgery Chiari Fundraiser Memorial Cancer Research Golf Outing Passport to Forever Tri State Society of Healthcare Engineers, Inc. StarShine Hospice Golf Classic Win a Wine Cellar StarShine Hospice Cornhole Charity Classic Kendall’s Second Annual EB Walk/Run Kilgore Elementary Dance-a-thon Kolping Seth Stevens Memorial Soccer Tournament Olivia J. Murray Second Annual Golf Outing Green Crest Christmas Walk Ronald McDonald House Charities of Greater Cincinnati All Saints School Han’s White Tiger Tae Kwon Do Break-a-Thon Ross-Butler Tech DECA Powder Puff Football Game Angels of Mercy the SaNyiah Rose Lynn Memorial Immaculate Heart of Mary Saint Ignatius of Loyola 7:30pm Music Group $1,000 – $2,499 Acoustic Night at Scotty’s The Basement Band Kenwood-Silverton-Madeira Kiwanis Golf Outing Paul Seiter Annual Memorial Fundraiser Nativity The Pop Opera Operation Beard for Bucks! St. Ursula Academy Orange & White Football Game Simon’s Fund The Spirit Of Cincinnatus $25,000 – $49,999 $5,000 – $9,999 Max Richard Thornsbury Foundation- CDH Research Bluegrass for Babies 2012 Auto Expo Team Jenna Children’s Charitable Care Golf Outing Abby’s Run for the Heart Walk for EB Cincinnati Golfers for Charity Association of Philippine Physicians of Greater Cincinnati 72 $2,500 – $4,999 M A K IN G A DI F F ERENCE A n E v e n i n g H o n o r i n g M i lt K a n to r Milt Kantor is a businessman, a husband, a father, a grandfather and a friend to many. As an avid philanthropist for most of his life, Milt has called upon many of his friends in the world of sports to share their time and resources for causes that are close to his heart. life and his generosity during an event that benefited the Cancer and Blood Diseases Institute at Cincinnati Children’s. Guests included Bobby Knight, Cris Collinsworth, “Big O” Oscar Robertson, Dolph Schayes, Bob Huggins and others who were thrilled to honor Milt while supporting the health and healing that Cincinnati Children’s provides for kids around the world. For his 85th birthday, Milt’s family gathered some of those sports legends, and 500 other friends, to celebrate his 73 Shred Day-Souders Financial Group Greek Philoptochos Society Riverside Athletic Boosters Catholic Kolping Society of Cincinnati Ethicon Endo-Surgery Inc. Indy Racing League Spooky Film Festival Hoops for the Cure Rockdale Temple Religious School Jimmy’s Limousine Service Saint Cecilia School Fundraiser First Christian Church Kai’s Love Hats Sycamore Community School District International Society for Research in Human Milk & Lactation Department of Audiology, Cincinnati Children’s Felix Leshey Foundation StarShine Plant and Flower Sale Saint Ignatius of Loyola Cengage Learning First Watch Restaurants Inc. Ms. Hadia Kahn Sycamore High School Student Council Event-Mr. Sycamore Lakota West High School- School Government Association Saint Margaret York Parish Cincinnati Carvers Guild Mr. Daigle Fisher KIDSovercancer Foundation St. Romain Dance Academy Cincinnati Precision Instruments Inc. Mr. and Mrs. Jeremy D. Focht Kindergarden School South Central Ohio Minority Supplier Development Council Cincy Kids 4 Kids Mr. Grant Forster La Salle High School Cintas Corporation Freestore Foodbank Mrs. Theresa L. Labbe Wise Amanda Thomson Piano Recital Cisco Systems, Inc. Frisch’s Restaurants Mr. and Mrs. Rodney Ladrigan Lakota Plains Junior School $500 – $999 Bethel International United Methodist Church Florence Lodge 33 Fraternal Order of Eagles Germania Society Gorilla Glue 1/2 Day Vacation Raffle Ben Kelhoffer Golf Outing Madeira City School District Shirley Mann Elementary School Sucker Sale “Ella’s Elves” Music Therapy Donation from Thomas Wright Lemier Warren County Records Center & Archives Bake Sale Clark Montessori School Foundation, Inc. From the Heart Church Ministries of Cincinnati Westboro Friends Church Coca-Cola Refreshments Nu Chapter Omega GE Aviation Woodland Elementary Walk-a-Thon Mr. and Mrs. Thomas G. Cody Sr. Ms. Joanne Geiger Dr. Ernest H. Lawhorn and Dr. Susan R. Lawhorn Coldwell Banker West Shell Mr. and Mrs. David Gilday Ms. Latisha Lewis Commonwealth Financial Network Mr. and Mrs. Olivier R. Gillier Dr. Anne Lucky Companions in Courage Foundation Girl Scout Daisy Troop #43840 Luxottica Retail Compass Group Girl Scout Troop #41725 Mann Elementary School Parkway Products Annual Golf Outing Gifts-in-Kind We thank the following individuals, corporations and organizations that helped ease the stress of our patients and families with their donations of toys, services and other non-cash gifts, valued at $500 or more. Adopt-a-BookHannah and Alex Laman Ms. Hanna Barlow Mr. and Mrs. Arnold R. Barnett The LaRosa Family Coney Island Girl Scout Troop #42599 The Marvin Lewis Community Fund Ms. Deanna Cox Mr. Gavin Goeser Mason Intermediate School Ms. Gail Cox Greater Cincinnati Relocation Council (GCRC) Ms. Virginia J. McDowell Ms. April Dalton Boy Scouts Pack 742 Ms. Barbara Decker GWRRA Chapter OhX2 Miami University Brent James and the Contraband Mr. and Mrs. Jason Dickman Mr. Justin Hall Hamilton County Sheriff ’s Department Miami University Residence Hall Association Messer Construction Company Amazon.com Bennett’s Beavers Ms. Tammy Brinegar The Dragonfly Foundation American Book Company Mr. and Mrs. Chad Blanchard Mr. and Mrs. Vasiliki Brunson Drawing Dreams Foundation Jeffrey Thomas Hayden Foundation Ms. Abby Murphy Mrs. Frank Anastasia Blue Ash Airport Days Mr. Daniel P. Bueche dunnhumbyUSA Mrs. Pat Hueslman Music to Heal APKE Premium Cleaning Bob Roncker’s Running Spot Bunnies By The Bay Mrs. Betty Dzeich Mr. and Mrs. Gary Huysse Nativity The Pop Opera Mr. Kevin Burton Elisha Lodge #106 IKEA West Chester Mr. Michael Nesi Mr. and Mrs. Thomas M. Carroll Mr. and Mrs. David Ellis Indian Hill Newport Aquarium Mr. and Mrs. Chris C. Ayers Ms. April Baker Books for Cure-Natasha Saputra and Megha Battina 74 75 Newport Independent SchoolNewport Intermediate School Response Marketing Inc. Terrace Park Elementary Roads, Rivers and Trails Mr. R. Jeffrey Thomas The Ohio State University College of Veterinary Medicine Dr. and Mrs. Jeffrey Robbins Mr. Richard Thomas The Alicia Rose “Victorious” Foundation Ms. Tari Torbeck Otis Spunkmeyer Inc. Mr. and Mrs. Jeff Rosenlieb Total Quality Logistics Ms. Catherine A. O’Toole Saint Susanna School Toyota Motor Sales, USA, Inc. Nina and Edward Paul Sans Souci Sorority Toys for Nicholas P.F. Chang’s China Bistro Scarlet Oaks Pepsi Beverages Company PetSmart The Friends of The School for Creative & Performing Arts Tri State Paranormal of Northern Kentucky Phillip A. Sharp Middle School Ms. Shannon Scott University of Cincinnati The PNC Financial Services Group Seven Hills Church University of Cincinnati-Public Safety Procter & Gamble Dr. and Mrs. Peter Y. Sheng Ursuline Academy Q Laboratories Inc. Skyline Chili of Middletown Ms. Amy Vaughan Readers Hideaway Sodexo Walmart Foundation Pete Delois Recreations Outlet Mr. and Mrs. Joel Staffilino Mr. and Mrs. Eugene K. Reis Ms. Lynova Stamper Warren County Records Center & Archives Mr. and Mrs. Justin D. Reno Ms. Kimetra Stone Ms. Carol Wobser Republic Capital Truck and Trailer Sale Stonz Ms. Tatiana M. Yewisiak F INANCIAL RE P O RT Ms. Missy Tripp Fiscal year 2012: July 1, 2011– June 30, 2012 (Dollars in Thousands) Op e r a t i n g R e v e n u e s a n d E x p e n s e s Op e r a t i n g revenues * Deceased Op e r a t i n g expenses As a nonprofit hospital and research center, we are grateful for all gifts made to Cincinnati Children’s. Unless otherwise noted, this report lists all donors who gave $500 or more in fiscal year 2012 (July 1, 2011 through June 30, 2012). We have made every effort to be accurate and complete with this listing. Should you find an error or omission, please call the Department of Development at 513-636-6347. 76 fy 2012 fy 2011 $1,286,492 252,401 149,858 162,987 1,851,738 $1,144,142 229,749 153,914 165,603 1,693,408 Salaries and Benefits Services, Supplies and Other Depreciation Interest Total Operating Expenses 1,072,522 514,968 119,574 15,926 1,722,990 1,033,823 479,392 110,716 16,104 1,640,035 Available to Reinvest in the Mission $128,748 $53,373 Net Hospital Patient Services Revenue Professional Services Revenue Research Grants Other Operating Revenue Total Operating Revenues 77 (Dollars in Thousands) Ass e ts Condensed Balance Sheet fy 2012 fy 2011 Cash and Equivalents Marketable Securities Patient Accounts Receivable, Net of Allowances for Uncollectible Amounts Other Current Assets Current Assets $169,667 258,903 214,355 126,599 769,524 $97,451 227,642 204,081 122,522 651,696 840,978 3,678 81,324 937,327 $2,632,831 851,701 4,620 74,261 886,162 $2,468,440 $227,089 20,365 247,454 $188,643 19,432 208,075 467,223 441,819 1,156,496 481,471 245,039 934,585 397,514 156,702 922,119 1,476,335 526,991 135,943 870,921 1,533,855 $2,632,831 $2,468,440 Property and Equipment, Net of Accumulated Depreciation Funds Held in Trust Other Long-term Assets Interest in Net Assets of Supporting Organizations Total Assets Liabilities and n e t a ss e ts P a t i e n ts O u tp a t i e n t v i s i ts S t a t i st i c a l H i g h l i g h ts fy 2012 fy 2011 fy 2010 fy 2009 fy 2008 Admissions (includes short stay) Average Length of Stay (days) Emergency Department Visits Patient Encounters 30,579 4.7 124,274 1,144,858 30,951 4.4 121,875 1,087,260 32,981 4.1 125,130 1,078,798 31,217 4.4 114,985 1,003,079 27,392 4.5 93,456 925,944 65,347 832,317 65,247 65,446 797,280 29,868 65,915 793,814 28,374 60,243 735,926 29,635 61,788 693,636 31,941 Inpatient Outpatient Surgical Hours 6,365 27,094 44,240 6,141 26,168 42,874 5,667 25,492 40,825 5,667 24,669 39,462 6,323 22,845 43,325 Active Medical Staff Total Employees Full-time Equivalents 1,572 12,932 10,976 1,516 12,654 10,781 1,498 12,368 10,455 1,442 11,666 9,871 1,292 10,680 9,104 Primary Specialty Test Referral Center Liabilities Accounts Payable and Accrued Expenses Current Portion of Long-term Debt Current Liabilities Long-term Debt Other Long-term Liabilities Total Liabilities N e t Ass e ts Unrestricted Net Assets Temporarily Restricted Net Assets Permanently Restricted Net Assets Total Net Assets Total Liabilities and Net Assets 78 Surgical procedures People 79 O UR LEA D ER S (Lists reflect leadership as of June 30, 2012) Off i c e r s o f t h e B o a r d B o a r d o f T r u st e e s Thomas G. Cody, Esq. Chairman Sharry Addison Pamela Terp Robert D. H. Anning Felicia Williams Carol Armstrong Craig Young Michael Fisher President and Chief Executive Officer Vicki L. Davies Treasurer Elizabeth A. Stautberg, Esq. Secretary Richard G. Azizkhan, MD Lynwood Battle Michael S. Cambron Willie F. Carden Jr. Lee A. Carter T r u st e e s E x Off i c i o Rt. Reverend Thomas Breidenthal The Episcopal Diocese of Southern Ohio Kay Fricke Family Advisory Council Thomas G. Cody, Esq. Katharine DeWitt Jr. Auxiliaries Nancy Krieger-Eddy, PhD Nancy Sorg President, Cooperative Society Michael Fisher Vallie Geier Marjorie Gilsdorf President, Junior Co-Operative Society Louis D. George Michael Hirschfeld, Esq. Joyce J. Keeshin M. Denise Kuprionis, Esq. Peggy Mathile Buffie Rixey President, Kindervelt T r u st e e s Em e r i t i Ralph Burchenal Jane Portman Barbara Fitch John Steinman Arnold W. Strauss, MD 80 Kroger Pettengill Performance Leadership Team A d o l e s c e n t H e a lt h C e n t e r Michael Fisher President and Chief Executive Officer o f G r e at e r C i n c i n n at i Janet Ach President Frank Biro, MD Director, Division of Adolescent Medicine Ca r e F o u n d a t i o n Michael Lee, DDS President Stephen Wilson, DMD, MA, PhD Director, Division of Pediatric Dentistry C o n va l e s c e n t H o s p i ta l f o r Ch i l d r e n Pamela Terp Chair Phillip C. Long President J a c k Ru b i n s t e i n F o u n d at i o n f o r D e v e l o p m e n ta l D i s o r d e r s JoAnn Hagopian President Mitchell Cohen, MD Vice Chair of Pediatrics for Clinical Affairs Brian D. Coley, MD Radiologist-in-Chief and Director, Department of Radiology Dwight E. Ellingwood Senior Vice President, Planning and Business Development Michael K. Farrell, MD Chief-of-Staff Jane Garvey Vice President, Marketing and Communications Tracy Glauser, MD Associate Director, Clinical Translational Outcomes and Health Services Research, Cincinnati Children’s Research Foundation Scott J. Hamlin Executive Vice President and Chief Operating Officer Cheryl Hoying, PhD, RN Senior Vice President, Department of Patient Services Production credits Produced by the Department of Marketing and Communications Cincinnati Children’s Hospital Medical Center Jane Garvey, Vice President William M. Kent Senior Vice President, Infrastructure and Operations Charles Dean Kurth, MD Anesthesiologist-in-Chief and Director, Department of Anesthesia Frederick Ryckman, MD Senior Vice President, Medical Operations James A. Saporito Senior Vice President, Development Elizabeth A. Stautberg, Esq. General Counsel and Senior Vice President, Legal and Public Affairs Arnold W. Strauss, MD Physician-in-Chief; Chair, Department of Pediatrics, University of Cincinnati; and Director, Cincinnati Children’s Research Foundation Jeffrey Whitsett, MD Interim Associate Director, Basic Sciences, Cincinnati Children’s Research Foundation 3 3 3 3 B U R N E T AV E N U E , C I N C I N N AT I , O H I O 4 5 2 2 9 - 3 0 2 6 WWW. C I N C I N N AT I C H I L D R E N S . ORG 2 Message from our CEO and Chairman 4 Message from our Finance Leaders 6 Casting Light on a Rare Lung Disease Tribute: William Kuenneth Schubert, MD 16 Deciphering the Mysteries of Eosinophilic Disorders 22 Revealing the Power of a Life-Altering Drug 28 Guiding Asthma Patients to a Better Quality of Life Elli Edwards, Jennifer Sennett, Shannon Studebaker 32 The Convalescent Hospital for Children: Evolving, Educating, Empowering Ph o t o g r a p h y 34 Donor Recognition Ryan Kurtz; additional photos from the Cincinnati Children’s archive 77 Financial Report 80 Our Leaders Beatrice Katz Uma R. Kotagal, MD Senior Vice President, Quality and Transformation T A BLE OF CONTENTS 14 Writer/project director 2 0 1 2 A N N UA L R E P O RT David Schonfeld, MD Director, Division of Developmental and Behavioral Pediatrics Elisabeth Baldock, PhD Senior Vice President, Human Resources Marianne F. James Senior Vice President, Information Services, and Chief Information Officer C I N C I N N AT I C H I L D R E N ’ S H O S P I TA L M E D I C A L C E N T E R Ch i l d r e n ’ s D e n t a l Richard G. Azizkhan, MD Surgeon-in-Chief I L LU M I N AT I N G D I S C O V E R I E S Affiliates Design Real Art Donor recognition Printing Wendling Printing Company Cincinnati Children’s Hospital Medical Center is a teaching affiliate of the University of Cincinnati College of Medicine. The medical center is accredited by The Joint Commission; CARF, The Rehabilitation Commission; and the Association ILLUMINATING for the Accreditation of Human Research Protection Programs, Inc. We have been awarded Magnet recognition from the American Nurses Credentialing Center for quality patient care and nursing excellence. Our pediatric residency training program is approved by the Accreditation Council for Graduate Medical Education. DISCOVERIES appropriately qualified persons of diverse backgrounds. The medical BRIDGING RESEARCH, CARE AND COMMUNITY ancestry, national origin, age, disability, political affiliation or Cincinnati Children’s affirmatively seeks to attract to its staff center does not discriminate against any employee or applicant based on race, color, creed, religion, sex, sexual orientation, status as a disabled veteran or veteran of the Vietnam conflict. Cincinnati Children’s ranked third among all pediatric hospitals in the 2012 U.S. News & World Report survey of best children’s hospitals. ©2012 Cincinnati Children’s Hospital Medical Center 2012 ANNUAL REPORT COVER Jordan Scott, 9, has eosinophilic esophagitis and is a patient of the Cincinnati Center for Eosinophilic Disorders. F r o m l e f t t o r i gh t : Cincinnati Children’s first home was a rented house. Tw o William Cooper Procter gave $2.5 million to build and endow the Children’s Hospital Research Foundation. Th r e e Cincinnati Children’s was the first pediatric hospital to have a building dedicated to research. It opened in 1931. F o u r Josef Warkany, MD, arrived January 1, 1932, for a one-year fellowship. He spent his entire career at Cincinnati Children’s, becoming a pioneer in the study of birth defects. F i v e Chemist and inventor Leland Clark, PhD, developed the first functional heart-lung machine. Using Clark’s machine, the cardiology team at Cincinnati Children’s performed the first open heart surgery. 1883 1924 Incorporation papers for the Protestant Episcopal Hospital for children are signed November 16, 1883. The hospital opens in a rented three-bedroom house in March 1884. 1887 Hospital moves to its second home. The new hospital opens with 20 beds on two wards and room for two additional wards. 1921 William Cooper Procter, president of Procter & Gamble, is elected president of the hospital’s board of trustees, a position he held until his death in 1934. The hospital’s name is changed to The Children’s Hospital. Procter forms a dynamic partnership with the newly appointed B.K. Rachford Chair of Pediatrics of the University of Cincinnati College of Medicine, Albert Graeme Mitchell, MD. Working together over the next decade, Procter and Dr. Mitchell increase the size of The Children’s Hospital, enlarge the staff and expand the hospital’s mission to include medical education and research. 1926 The Children’s Hospital establishes an academic affiliation with the College of Medicine as the Department of Pediatrics. Dr. Mitchell is the first to be both chair of Pediatrics and physician-in-chief of The Children’s Hospital, a tradition that continues today. On December 6, the hospital moves into its new, 200-bed facility adjacent to the college, built on land Procter selected and purchased. 1928 Dr. Mitchell advocates for research at The Children’s Hospital. In December, Procter announces a gift of $2.5 million to build and endow The Children’s Hospital Research Foundation. 1931 The Children’s Hospital Research Foundation opens. The Children’s Hospital is the nation’s first pediatric hospital with a building dedicated to research. 1932 Josef Warkany, MD, arrives from Vienna for a one-year research fellowship. He spends his entire and highly productive career at Cincinnati Children’s. Known as the father of teratology, Dr. Warkany did pioneering research on nutritional and environmental factors that cause birth defects. F r o m l e f t t o r i gh t : Albert Sabin, MD, spent 30 years at Cincinnati Children’s. The Sabin oral polio vaccine was adopted by the World Health Organization in its campaign to eradicate polio worldwide. Tw o In 1988, Jeffrey Whitsett, MD, announced his research team had identified and cloned two proteins essential for human surfactant. Today surfactant replacement therapy is routinely used to save the lives of premature infants with respiratory distress syndrome. Th r e e Richard Ward, PhD, began studying rotavirus in 1981. His research, in partnership with David Bernstein, MD, led to development of a safe, effective vaccine to prevent rotavirus infection. The vaccine is now used around the world. F o u r Cincinnati Children’s broke ground for a new clinical sciences building in 2012. The 425,000 square foot building will provide space to consolidate and expand patient-oriented research activities. 1957 1939 1951 Albert Sabin, MD, joins The Children’s Hospital Research Foundation. His research proved that poliovirus enters the body through the digestive tract. He also found polioresistant antibodies in some children, suggesting they had been infected by a weakened strain that produced immunity. Based on these observations, he developed the world’s first attenuated (weakened) live-virus vaccine–the Sabin oral polio vaccine. Chemist Leland Clark, PhD, then based at Antioch College, brings his bubble defoam oxygenator heart-lung bypass machine to Cincinnati Children’s. Cardiologist Samuel Kaplan, MD, and surgeon James Helmsworth, MD, work with Clark to perfect it. A prolific inventor, Dr. Clark also developed the Clark oxygen electrode, which is used worldwide in medical and industrial applications. 1942 Ashley Weech, MD, is named chairman of Pediatrics and director of The Children’s Hospital Research Foundation. After WWII ends, he expands the faculty, adding directors of new subspecialty divisions as the field of pediatrics becomes increasingly specialized. Building a Research Legacy 1952 Using the heart-lung machine, the Cincinnati Children’s team performs the earliest open heart surgery, reported in the Journal of the American Medical Association (October 4, 1952). 1956–2012 on back cover The World Health Organization chooses Sabin’s vaccine for worldwide testing. Millions of doses are given in Russia, Holland, Mexico, Chile, Sweden and Japan. 1960 The first US test of the Sabin oral polio vaccine begins in Cincinnati on April 24, 1960, known as Sabin Sunday. More than 20,000 children received the vaccine. 1976 1963 Edward Pratt, MD, is named chairman of Pediatrics and director of The Children’s Hospital Research Foundation. The Clinical Research Center is established, with William K. Schubert, MD, as its founding director. 1968 The Institute for Developmental Research (IDR) opens. The building doubled office and laboratory space, and allowed a large influx of research scientists. 1 8 8 3 – 1 9 5 5 o n FRONT c o v e r Lonnie Wright, MPH, PhD, is appointed the hospital’s first full-time president and CEO. 1979 Dr. Schubert succeeds Dr. Pratt as chairman of the Department of Pediatrics and director of the Children’s Hospital Research Foundation. 1983 Dr. Schubert is appointed president and CEO. 2003 1988 1993 Neonatologist Jeffrey Whitsett, MD, announces his team has identified and cloned two proteins essential to human surfactant. The discovery made it possible to produce synthetic human surfactant for treating premature infants with respiratory distress syndrome. Thomas Boat, MD, succeeds Dr. Schubert as chairman of Pediatrics and director of the Children’s Hospital Research Foundation. 1996 2004 James M. Anderson succeeds Dr. Schubert as president and CEO. The rotavirus vaccine developed by Richard Ward, PhD, and David Bernstein, MD, is licensed in Mexico. Today the vaccine is used in over 100 countries, and the World Health Organization has recommended that rotavirus vaccine be included in all national immunization programs. 1998 1991 First new research building since 1968 opens, providing space for 19 research programs in 240 new labs. Research is increasingly focused on molecular genetics. Demolition of the 1926 hospital begins to make way for a new research building. Construction begins in 2004. Cincinnati Children’s begins an ambitious building expansion. Over the next four years, the Sabin Education Center, a research wing, a garage, and a new hospital building (now called Location A) are added to the Burnet Campus. Improving Child Health 2007 Location S opens on the site of the 1926 hospital. The building adds 415,000 square feet for research. Reflecting the depth and breadth of its research program, Cincinnati Children’s is now second in the nation in NIH grants for pediatric research. Arnold Strauss, MD, succeeds Dr. Boat as chair of Pediatrics and director of the Cincinnati Children’s Research Foundation. 2010 Michael Fisher succeeds James Anderson as president and CEO. 2012 Cincinnati Children’s breaks ground for a 425,000 square foot clinical sciences building that will provide space to consolidate and expand patient-oriented research. When the building opens in 2015, Cincinnati Children’s will have 1.4 million square feet for research. Performance Leadership Team A d o l e s c e n t H e a lt h C e n t e r Michael Fisher President and Chief Executive Officer o f G r e at e r C i n c i n n at i Janet Ach President Frank Biro, MD Director, Division of Adolescent Medicine Ca r e F o u n d a t i o n Michael Lee, DDS President Stephen Wilson, DMD, MA, PhD Director, Division of Pediatric Dentistry C o n va l e s c e n t H o s p i ta l f o r Ch i l d r e n Pamela Terp Chair Phillip C. Long President J a c k Ru b i n s t e i n F o u n d at i o n f o r D e v e l o p m e n ta l D i s o r d e r s JoAnn Hagopian President Mitchell Cohen, MD Vice Chair of Pediatrics for Clinical Affairs Brian D. Coley, MD Radiologist-in-Chief and Director, Department of Radiology Dwight E. Ellingwood Senior Vice President, Planning and Business Development Michael K. Farrell, MD Chief-of-Staff Jane Garvey Vice President, Marketing and Communications Tracy Glauser, MD Associate Director, Clinical Translational Outcomes and Health Services Research, Cincinnati Children’s Research Foundation Scott J. Hamlin Executive Vice President and Chief Operating Officer Cheryl Hoying, PhD, RN Senior Vice President, Department of Patient Services Production credits Produced by the Department of Marketing and Communications Cincinnati Children’s Hospital Medical Center Jane Garvey, Vice President William M. Kent Senior Vice President, Infrastructure and Operations Charles Dean Kurth, MD Anesthesiologist-in-Chief and Director, Department of Anesthesia Frederick Ryckman, MD Senior Vice President, Medical Operations James A. Saporito Senior Vice President, Development Elizabeth A. Stautberg, Esq. General Counsel and Senior Vice President, Legal and Public Affairs Arnold W. Strauss, MD Physician-in-Chief; Chair, Department of Pediatrics, University of Cincinnati; and Director, Cincinnati Children’s Research Foundation Jeffrey Whitsett, MD Interim Associate Director, Basic Sciences, Cincinnati Children’s Research Foundation 3 3 3 3 B U R N E T AV E N U E , C I N C I N N AT I , O H I O 4 5 2 2 9 - 3 0 2 6 WWW. C I N C I N N AT I C H I L D R E N S . ORG 2 Message from our CEO and Chairman 4 Message from our Finance Leaders 6 Casting Light on a Rare Lung Disease Tribute: William Kuenneth Schubert, MD 16 Deciphering the Mysteries of Eosinophilic Disorders 22 Revealing the Power of a Life-Altering Drug 28 Guiding Asthma Patients to a Better Quality of Life Elli Edwards, Jennifer Sennett, Shannon Studebaker 32 The Convalescent Hospital for Children: Evolving, Educating, Empowering Ph o t o g r a p h y 34 Donor Recognition Ryan Kurtz; additional photos from the Cincinnati Children’s archive 77 Financial Report 80 Our Leaders Beatrice Katz Uma R. Kotagal, MD Senior Vice President, Quality and Transformation T A BLE OF CONTENTS 14 Writer/project director 2 0 1 2 A N N UA L R E P O RT David Schonfeld, MD Director, Division of Developmental and Behavioral Pediatrics Elisabeth Baldock, PhD Senior Vice President, Human Resources Marianne F. James Senior Vice President, Information Services, and Chief Information Officer C I N C I N N AT I C H I L D R E N ’ S H O S P I TA L M E D I C A L C E N T E R Ch i l d r e n ’ s D e n t a l Richard G. Azizkhan, MD Surgeon-in-Chief I L LU M I N AT I N G D I S C O V E R I E S Affiliates Design Real Art Donor recognition Printing Wendling Printing Company Cincinnati Children’s Hospital Medical Center is a teaching affiliate of the University of Cincinnati College of Medicine. The medical center is accredited by The Joint Commission; CARF, The Rehabilitation Commission; and the Association ILLUMINATING for the Accreditation of Human Research Protection Programs, Inc. We have been awarded Magnet recognition from the American Nurses Credentialing Center for quality patient care and nursing excellence. Our pediatric residency training program is approved by the Accreditation Council for Graduate Medical Education. DISCOVERIES appropriately qualified persons of diverse backgrounds. The medical BRIDGING RESEARCH, CARE AND COMMUNITY ancestry, national origin, age, disability, political affiliation or Cincinnati Children’s affirmatively seeks to attract to its staff center does not discriminate against any employee or applicant based on race, color, creed, religion, sex, sexual orientation, status as a disabled veteran or veteran of the Vietnam conflict. Cincinnati Children’s ranked third among all pediatric hospitals in the 2012 U.S. News & World Report survey of best children’s hospitals. ©2012 Cincinnati Children’s Hospital Medical Center 2012 ANNUAL REPORT COVER Jordan Scott, 9, has eosinophilic esophagitis and is a patient of the Cincinnati Center for Eosinophilic Disorders.
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