SickKids
Healthier Children. A Better World.в„ў
Department of Paediatrics
Annual Report 2007–08
“A child’s life is like a piece
of paper on which every
passerby leaves a mark.”
- Chinese proverb
Contents
2
Chair’s Report
6
Division of Adolescent Medicine
14
Division of Cardiology
26
Division of
Clinical and Metabolic Genetics
34
Division of
Clinical Pharmacology & Toxicology
46
Division of
Developmental Paediatrics
54
Division of Endocrinology
62
Division of Gastroenterology,
Hepatology and Nutrition
74
Division of Haematology/Oncology
90
Division of Immunology/Allergy
96
Division of Infectious Diseases
104
Division of Neonatology
116
Division of Nephrology
122
Division of Neurology
134
Division of
Paediatric Emergency Medicine
140
Division of Paediatric Medicine
148
Division of Respiratory Medicine
156
Division of Rheumatology
164
Bloorview Kids Rehab
166
Transplant Centre
168
Paediatric Housestaff
170
Paediatric Grand Rounds
173
Promotions/Recognition
174
Awards
175
Resident and Fellow
Awards and Achievements
178
Annual Resident and
Fellow Research Day
Chair’s Report
2007-08 was a very special year in the Department of Paediatrics at the The
Farid Mahmud (Endocrinology), Mahendra Moharir (Neurology) and Rulan Parekh
Hospital for Sick Children and University of Toronto: one, not only of security,
(Nephrology). This group represents the full spectrum of job profiles: clinician
but also about renewal, growth and development, innovation and recognition.
scientists, investigators, teachers, educators and specialists. The department and
hospital will be well served for many years to come by this highly talented group.
Security was present in our funding plan which has underpinned our ability to
recruit new, and retain the existing, outstanding faculty. Last year our ranks were
There have been and will also be more transitions in the months and year to come.
enormously enriched by the appointment of new Division Heads in Endocrinology
Searches are underway in at least three divisions for new heads. At the Paediatric
(Mark Palmert), Developmental Paediatrics (Darcy Fehlings), Rheumatology (Brian
Executive level, Rayfel Schneider has seamlessly taken over as Associate Chair of
Feldman) and Gastroenterology, Hepatology and Nutrition (Anne Griffiths), as well
Medical Education and his team has already garnered some impressive awards:
as David Grant as the new Director of the SickKids Transplant Centre. In addition,
2
we have been able to build by recruiting to most divisions: Aleixo Muise
Adelle Atkinson (Director of Postgraduate Medical Education), the PAIRO Residency
(Gastroenterology/Hepatology/Nutrition), Sarah Alexander and Angela Punnett
Excellence Award for our program in Paediatrics; Stacey Bernstein (Director of
(Haematology/Oncology), Anu Wadhwa (Infectious Diseases), Luc Mertens and Lars
Undergraduate Medical Education), a W.T. Aikens Award for small group teaching;
Gross-Wortmann (Cardiology), Sarah Bowdin (Clinical Genetics), Chris Tomlinson
Karen Leslie (Adolescent Medicine), the Helen Batty Award for Faculty Development;
and Linh Ly (Neonatology), Theo Moraes (Respiratory Medicine), Yaron Finkelstein,
Jonathan Pirie (Emergency Medicine) and Ben Saxon (Haematology/Oncology)
Sanjay Mehta and Trent Mizzi (Emergency Medicine), Zia Bizmilla (Paediatric
awards for excellence in postgraduate education; and Anna Banerji (Infectious
Medicine), Angela Orsino and Evdokia Anagnostou (Developmental Paediatrics),
Diseases), the Educational Excellence in Community Care Award.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
These awards are, I believe, a direct result of the commitment we have made
Besides the plethora of awards in education, there are also many examples
as a department to excellence in education. The addition of an education scholar
of achievement in research and clinical care. In 2005-06, the year for which
to the department in early 2009 will further enhance our commitments, as will
we have the latest figures, the department ranked second amongst clinical
our ongoing support of faculty development in education. More challenges await
departments in the Faculty of Medicine in the amount of external grant funding:
as we expand the size of the Medical School classes and move to an even more
over $41 million! Annually, we publish over 750 papers, our faculty present at
distributed model of education. In the meantime, we continue to increase the size
all the major meetings: plenary sessions, workshops and original research. The
of our residency program and our fellowship trainees. Each year, the group coming
culture of research, as has been planned, permeates all aspects of our activities.
to our program seems more talented than ever before. The theme of the photos
New team grants have been awarded by the CIHR recently in asthma (PJ Subbarao
for this annual report is, quite appropriately, Commitment to Education.
and colleagues) and obesity (Brian McCrindle, Jill Hamilton and their extensive
After seven years as Associate Chair of Research, Norman Rosenblum is taking
and Meredith Irwin (Haematology/Oncology), Anne Opavsky (Infectious Diseases)
on a new and exciting challenge: Director of Clinician-Scientist Training Programs
and Rae Yeung (Rheumatology). Berge Minassian has been recognized nationally
in the Faculty of Medicine at the University of Toronto. Norm has made major
and internationally for his groundbreaking work in epilepsy, and David Malkin has
contributions to the development of our department’s research efforts and
been feted by the Israel Cancer Research Foundation as a Man of Distinction.
group), and personal awards to Bob Jankov (Neonatology), Uri Tabori, Lillian Sung
deserves our enormous thanks and best wishes. Meredith Irwin (Haematology/
Oncology) will take over this role and I have no doubt will bring her enormous
The Resident Research Day in May 2008 was once more a great success with
energy, enthusiasm and her own stamp to the task.
over 110 oral and poster presentations by our trainees. This year’s keynote
speaker, David Dunger, Professor of Pediatrics from Cambridge University, U.K.,
We thank also Seonag Macrae, now SickKids Executive Vice-President, for so ably
wonderfully illustrated the development and evolution of a career in clinical
representing the Child Health Services portfolio on the Paediatric Executive from
research. The winners of the resident awards are listed on page 175.
2003 to 2008, and welcome her replacement, Marilyn Monk, who is already actively
engaged in numerous issues of mutual importance to the hospital and department.
Clinical innovations and excellence abound. Just a few examples: Eyal Cohen
and colleagues are following the legacy of Dr. Norman Saunders in pursuing
Once again, the Department of Paediatrics performed superbly in the annual
new models for the care of children with complex care needs; Andrew Redington
Faculty of Medicine promotions process. Debra Katzman (Adolescent Medicine)
and his group in Cardiology and the Labatt Family Heart Centre are breaking new
is now professor, and the group of 11 listed on page 173, are all now associate
ground in the Cardiac Diagnostic and Interventional Unit (CDIU) which opened last
professors: this is a richly deserved recognition of their academic achievements.
year; Jill Hamilton and an interdisciplinary group are probing new approaches to
the management of hypothalamic obesity; Sylvain Baruchel is testing new cancer
therapies in Phase I clinical trials, and the entire Oncology group participates
in the relentless success of the Children’s Oncology Group, as they continuously
improve the outcomes of childhood cancers.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
3
A couple of new endowed chairs were announced in the past year: Andrew Redington
academic and community positions. Second, we are now in a period of growth in
has been awarded the BMO Financial Group Chair in Cardiology and Earl Silverman,
the health-care sector. How long can this be sustained? Third, our capabilities in
Rheumatology, the Ho Family Chair in Autoimmune Diseases. On page 174, we list
all three pillars of academia have long since outstripped the capacity of our physical
all the winners of the departmental awards-heartiest congratulations to all.
plant: things are going to be quite tight until the new buildings are completed. Fourth,
our training programs are being pulled in a number of different directions, including
We have initiated two new programs within the department: first, the transition
the need to train more Canadians in a number of subspecialties, as well as meeting
position aimed at senior trainees wishing to spend one to two more years honing
our social responsibilities by helping to train paediatric subspecialists who return to
their academic skills before assuming a faculty position, and second, a faculty
the developing world. Finally, we need to pay increasingly close attention to clinical
development program that encourages the members of our department to spend
care, focussing on excellence, access, safety and innovation.
periods of time away from SickKids and the University of Toronto, acquiring new
skills which they can bring back to enrich their own careers as well as our activities.
In closing, it continues to be an honour and joy to serve as the chair/chief of this
department. I am given daily reminders, not only at home but everywhere I go in the
But we are not this successful in isolation. The support of the administration at
world, of just how accomplished our faculty is. Thanks to all for your wonderful work
SickKids and the Decanal Office in the Faculty of Medicine is essential to all of
on behalf of the department, hospital, and university, but mostly for the children
our activities. Mary Jo Haddad, SickKids President and CEO, and Cathy Whiteside,
and their families who entrust us with their lives.
U of T Dean of Medicine, remain staunch supporters of our department. I cannot
overstate our appreciation for the efforts of Mary Jo, Cathy and their teams.
So is everything rosy, or are there challenges that need our attention? The past
five years have seen enormous new recruitment to our faculty. The pace of growth is
very unlikely to continue indefinitely; in fact, the job market may become overheated
with a limit on new academic positions for highly trained individuals. There is a
need for an ongoing nationwide dialogue on the training of paediatricians for both
4
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
DENIS DANEMAN, MB, BCh, FRCPC
Chair of Paediatrics, University of Toronto
Paediatrician-in-Chief, The Hospital for Sick Children
R.S. McLaughlin Chair in Paediatrics, at The Hospital for Sick Children
Thanks to all for your wonderful work on behalf
of the department, hospital, and university, but mostly
for the children and their families who entrust us with their lives.
- Dr. Denis Daneman
Dr. Miriam Kaufman
DIVISION HEAD
Dr. Debra K. Katzman
FULL-TIME
Dr. Eudice Goldberg
Dr. Miriam Kaufman
Dr. Karen Leslie
Dr. Cathleen Steinegger
6
PART-TIME
Dr. Miriam Rossi
Dr. Rahul Saxena
Dr. Boonying Manaboriboon
Dr. Ellie Vyver
Dr. Mona Basker
CLINICAL FELLOWS
Dr. Rosawan Areemit
Dr. Abigail Harrison-Kong
Dr. Nuray Kanbur
ADMINISTRATIVE STAFF
Sharon Dolphin
Melissa Keown
Burnett Wint
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Division of Adolescent Medicine
OVERVIEW
The goal of the Good 2 Go Transition Program is to
The team continues to collaborate with programs/
The Division of Adolescent Medicine provides
prepare all youth with chronic health conditions to
clinics within the hospital and with community
state-of-the-art, comprehensive specialty care to
leave SickKids by the age of 18 with the necessary skills
partners. The Transition Program offers supervision
patients up to 18 years of age, focusing its clinical
and knowledge to advocate for themselves, maintain
and mentorship to interdisciplinary trainees in the
activities in five program areas: eating disorders,
health-promoting behaviours and utilize adult
area of transition.
transition (Good 2 Go), substance abuse, young
health-care services appropriately and successfully.
The Transition Program’s poster presentation,
families and complex adolescent problems.
The Eating Disorders Program at SickKids continues
The team continues to develop and customize new
The Good 2 Go Transition Program: Helping Programs
resources, including colourful clinic posters and
Promote Healthy Transitions from the Paediatric to
to provide a variety of integrated clinical services
timelines to encourage patients, families and
the Adult Health-Care Systems, was awarded best
(inpatient, day treatment, outpatient and consultation)
practitioners to begin preparing for transition to adult
poster at the Interprofessional Practice Symposium
to adolescents and their families. All aspects of the
care. MyHealth Passport, an initiative introduced last
held at SickKids in November 2007. In addition, the
program are multidisciplinary and family-based,
year, is being evaluated and used in a research project
Good 2 Go Transition Program was recognized by the
allowing for the flexibility in the program to best meet
in the Inflammatory Bowel Disease Clinic.
2007 accreditation team as one of five leading
practices in the hospital.
the particular needs of each individual adolescent.
New initiatives have included the integration of
The team has recently received funding from the SickKids
multi-family group therapy (MFGT) at SickKids and
Foundation to develop clinical pathways for youth, ages
The Adolescent Substance Abuse Outreach Program
throughout the province. MFGT was recognized by
12 to 18 years. The pathways will be used at clinic visits
and the Substance Abuse Day Treatment Program
the 2007 accreditation team as one of five leading
throughout the hospital, ensuring that staff are
offer comprehensive clinical care to adolescents
practices in the hospital. The highly successful
consistently aware of their role in facilitating transition.
and their families with substance abuse problems.
Ontario Community Outreach Program (a collaborative
The team also received funding from the Kidney
The spectrum of services includes both outpatient
of SickKids, University Health Network and the
Foundation of Canada to work collaboratively with staff
services as well as more intensive, five days a week
MOHLTC) continues to train health-care professionals
from the University Health Network to explore the best
day treatment. Patients receive health assessments
around the province to assess and treat eating
way to modify an existing adult self-management program
and follow up that address both the medical sequelae
disorders, thus allowing more patients to receive
for use with youth who have chronic health conditions.
of their substance use, as well as the other medical
care in their own community.
concerns that result from high-risk health behaviours.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
7
to reduce high-risk health behaviours by promoting
The Day Treatment Program expanded its services last
both at local and regional levels, and provide
year to include a summer program, combining
expertise in child and youth substance use and abuse
healthy sexuality and healthy sexual relationships;
treatment, academic and medical support to day
to various committees dealing with prevention and
assistance to health-care teams in recognizing the
treatment patients. This summer’s program will
treatment issues at the municipal, provincial, and
role of the mind and body regarding various health-
build upon the success of last year’s experience.
national levels. Expertise in the area of substance
care processes; and maintaining a presence within
abuse prevention has been highlighted this year
the community to advocate for the health-care
The program also provides training and education
through work with the City of Toronto task force
needs of youth. These services are provided in the
to many levels of learners from different health
and working group on substance abuse prevention.
Adolescent Clinic as well as in collaboration with renal,
cardiac and lung transplant programs, the HIV and
professions, including postgraduate Paediatrics and
SLE clinics, and through inpatient consultations. Last
Psychiatry, and child and youth counselling trainees.
The Substance Abuse Program is building on prior
New training initiatives for Adolescent Medicine
collaboration with the Centre for Addiction and Mental
year, a combined CAPP/SCAN (Suspected Child Abuse
fellows that were implemented last year have been
Health for a project that will pilot screening and
and Neglect) clinic was established to collaboratively
further enhanced. As well, specialized training in
assessment tools for youth with substance abuse,
assess and provide education and support for
substance use and abuse for paediatric residents
other high-risk behaviours and concurrent disorders.
adolescents identified as engaging in high-risk sexual
behaviours. This past year, the CAPP clinic created a
has been launched with the creation of a new
interdisciplinary clinic specifically addressing the
The Complex Adolescent Problem Program (CAPP)
new link to the Substance Abuse Treatment Program
complex needs of patients in the Substance Abuse
continues to focus on adolescents with chronic illness,
allowing youth in the Substance Abuse Program to
Program. In addition to the many outreach educational
disability or complicated medical conditions. The goal
receive their medical care in an interdisciplinary clinic
activities of the program, staff presented at national
of CAPP is to provide access to expert adolescent
involving team members from both programs. CAPP
and international conferences this year at the invitation
health-care services to youth, both within the
continues to build partnerships with local agencies
of leaders in the fields of paediatric health-care and
community and those already patients at SickKids.
in an effort to enable youth in the downtown core
congenital heart disease. Members of the staff are
Objectives of the program include provision of
to access health information and necessary health
involved in many aspects of service development,
comprehensive multidisciplinary care in an effort
services otherwise unavailable to them. In addition,
collaboration with the Toronto Children’s Aid Society
8
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
for youth in care to access medical and psychosocial
Assessment and intervention in the areas of growth
activities include the medical complications of eating
services. Increasingly, the CAPP team is being
and development, infant and adolescent mental health,
disorders with specific emphasis on osteoporosis and
consulted regarding youth with clinical conditions
maltreatment, and social determinants of health
brain structure and function, epidemiology of early-
that are considered diagnostic dilemmas.
provide the basis for research in adolescent parenting.
onset eating disorders, evaluation of family-based
Management of these conditions requires an
The project is now completing the assessment phase
treatments for adolescents with eating disorders,
interdisciplinary team skilled in understanding
and is entering the intervention phase with an emphasis
the evaluation of the use of information technology
the interplay of physical and emotional factors
on maternal and infant mental health, and ultimately
for health promotion with youth, treatment outcome
that contribute to presenting symptoms.
improving child/parent relationships. Interprofessional
in adolescent substance use, HIV educational
team members continue to provide resources and
interventions with incarcerated youth, health values
The Young Families Program (YFP) focuses on providing
education to health professionals in a variety of
in adolescents with chronic illnesses, the assessment
health care, advocacy, support and education to
settings through conference presentations and
and evaluation of high risk parents and their children,
high-risk adolescent parents and their children. The
committee participation.
the evaluation of transition of care to the adult healthcare system, and faculty development and mentoring.
YFP collaborates with several agencies that provide
services to a diverse group of adolescent parents,
The Division of Adolescent Medicine at SickKids is
including prenatal homes, health services and child
the largest of its kind in Canada, with a diverse
The division trains physicians (from Paediatrics,
protection agencies. In particular, the YFP provides a
interprofessional clinical team and staff. This past
Psychiatry and Family Medicine), nurses, psychologists,
consultation clinic at Jessie’s Centre for Teenagers
year, two nurses in Adolescent Medicine successfully
social workers, dietitians, art therapists and child
and provides educational, supportive and policy
passed the newly instituted nurse practitioner
youth counsellors in all aspects of adolescent health.
recommendations. In partnership with the SCAN team,
examination and are now registered with the College
the High Risk Project has been operational since
of Nurses of Ontario as nurse practitioners.
Members of the division continue to make significant
educational contributions locally, provincially, nationally
2004 when external funding was established to
standardize clinical care for adolescent parents
Research activities are an integral part of the activities
and internationally. Members of the division hold
and their children.
of the faculty and trainees of the division. The division
leadership roles in the SickKids Summer Student
has significantly expanded its research, addressing
Program, the Centre for Faculty Development, and
a multitude of adolescent health issues. Research
organizing international annual scientific meetings
on adolescent health.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
9
Division members play a leading role in national
PUBLICATIONS
and international clinical, education and research
Bravender T, Bryant-Waugh R, Herzog D, Katzman D,
Pinzon J, McDuff P: Sex and sexual health: A survey
committees, including the Infant Mental Health
Kreipe RD, Lask B, Le Grange D, Lock J, Loeb K,
of Canadian youth and mothers. Paediatrics and Child
Health 2008: 13(1): pp 25-30.
Frappier J, Kaufman M, Baltzer F, Elliott A, Lane M,
Promotion Project, Canadian Paediatric Society,
Madden S, Nicholls D, O’Toole J, Pinhas L, Rome E,
American Academy of Paediatrics, Society for
Sokol-Burger M, Wallen U, Zucker N: workgroup for
Adolescent Medicine, Canadian Association for
classification of eating disorders in children and
Infectious Diseases and Immunization Committee
Adolescent Health, Canadian Association for Medical
adolescents. Classification of child and adolescent
(Bortolussi R, Moore DL, Robinson JL, Rousseau-
Education and the Academy for Eating Disorders.
eating disturbances. Workgroup for classification
Harsany E, Samson LM (Principal Author) and
of eating disorders in children and adolescents
Adolescent Medicine Committee (Findlay S, Pinzon J,
Over the past three years, the division has taken the
(WCEDCA). International Journal of Eating Disorders
Taddeo D, Katzman DK), Canadian Paediatric Society
lead in pursuing paediatric subspecialty certification
2007: 40(Suppl): pp S117-S122.
(CPS): HPV vaccine for children and adolescents.
Paediatrics and Child Health 2007: 12(7): pp 599-603.
for Adolescent Medicine through the Royal College
of Physicians and Surgeons of Canada (RCPSC).
Egan-Lee E, Hollenberg E, Dematteo D, Tobin S,
Adolescent Medicine was endorsed at the RCPSC’s
Oandasan I, Beduz A, Kwan D, Leslie K, Lee J,
Jayaraman GC, Shields S, Rossi M, Haase D, Singh A,
Council in May 2007, and is now the 63rd recognized
Tassone M, Merkley J, Lingard L, Sinclair L, Lowe M,
Predy G, Neudorf C, Ogilvie G, Rekart M, Beaudoin C,
Reeves S: Catalyzing and sustaining communities
Hammond G, Toye B, Wong T and the SY-Track Study
of collaboration around interprofessional care: An
Team: Street youth in Canada: findings from enhanced
HONOURS AND AWARDS
evaluation of four educational programs. Journal of
surveillance of Canadian street youth, 1999-2003.
Katzman DK: Eating Disorder Champion Award, 2007.
Interprofessional Care 2008: 22(3): pp 317-319.
Ottawa, ON: Public Health Agency of Canada, 2006.
discipline of the RCPSC as a subspecialty of Paediatrics.
Cat. No. HP5-15/2006 ISBN 0-662-49069-X.
Leslie K: Helen Batty Award for Teaching in Faculty
Development, 2008.
10 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Accessed March 5, 2007.
Misra M, Prabhakaran R, Miller KK, Goldstein A,
Katzman DK, Frappier JY, Goldberg E: Adolescent
Leslie K: Youth substance use and abuse: challenges
medicine: a new paediatric subspecialty in Canada.
and strategies for identification and intervention.
Mickley D, Clauss L, Lockhart P, Cord J, Herzog DB,
(Invited submission). Paediatrics and Child Health
Canadian Medical Association Journal 2008: 178(2):
Katzman DK, Klibanski A: Weight gain and restoration
2008: 13(1): pp 12-14.
pp 145-148.
of menses as predictors of bone mineral density
Katzman DK: Irregular menses: a warning sign of
Leslie K: Harm reduction: an approach to reducing
Journal of Clinical Endocrinology and Metabolism
vomiting for weight control. Journal of Adolescent
risky health behaviours in adolescents. Paediatrics
2008: 93: pp 1231-1237.
Health 2008: 42(5): pp 429-431.
and Child Health 2008: 13(1): pp 53-56.
change in adolescent girls with anorexia nervosa-1.
Richardson D, Glover TS, Nasmith L, Leslie K,
Kirsh G, McVey G, Tweed S, Katzman DK:
Misra M, Miller KK, Cord J, Prabhakaran R,
Bandiera G, Paterson M, Power B, Oandason I, Frank
Psychosocial profiles of young adolescent females
Goldstein M, Katzman DK, Herzog DB, Klibanski A:
JR: The CanMEDS train-the-trainer collaborator faculty
seeking treatment for an eating disorder. Journal of
Relationships between serum adipokines, insulin
development program. Ottawa: The Royal College of
levels and bone density in girls with anorexia nervosa.
Physicians and Surgeons of Canada 2007.
Adolescent Health 2007: 40(4): pp 351-356.
Journal of Clinical Endocrinology and Metabolism
Korszak D, Connolly B, Baron T, Katzman DK,
2007: 92(6): pp 2046-2052.
Steinegger C, Katzman DK: Interviewing the
adolescent with an eating disorder. Adolescent
Bernstein S: Safety and efficacy of image-guided
gastrostomy (G) and gastrojejunostomy (GJ) tubes
Misra M, Prabhakaran R, Miller KK, Goldstein MA,
Medicine State of the Art Reviews 2008: 19(1):
in children and adolescents with primary psychiatric
Mickley D, Clauss L, Lockhart P, Cord J, Herzog DB,
pp 18-40.
illness. International Journal of Eating Disorders
Katzman DK, Klibanski A: Prognostic indicators of
2007: 40(7): pp 645-651.
changes in bone density measures in adolescent
Tallett S, Lingard L, Hellmann J, Hilliard R, Hurley J,
girls with anorexia nervosa. Journal of Clinical
Leslie K, Jefferies A, Mian M, Pirie J, Rosenfield J,
Endocrinology and Metabolism 2008: 93(4):
Schneider R, Spero L: Measuring educational
pp 1292-1297.
workload: a pilot study of paper-based and PDA
tools. Medical Teacher 2008: 30(3): pp 296-301.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 11
FUNDING
Vyver E, Steinnegger C, Katzman DK: Eating disorders
Pinhas L, Katzman DK, Dimitropoulos G, Woodside B:
and menstrual dysfunction in adolescents. Annals
Binging and bulimia nervosa in children and adolescents.
Bulimic eating disorders in children and adolescents:
of the New York Academy of Sciences 2008: 1135:
In: Child and Adolescent Eating Disorders (Jaffa T,
Canadian Paediatric Surveillance Program (CPSP).
pp 253-264.
McDermott, eds.). New York: Cambridge University
Pinhas L, Heinmaa M, Boachie A, Crosby R, Katzman
Press, 2007.
DK (Senior Investigator). Psychiatric Endowment
BOOKS AND BOOK CHAPTERS
Fund at SickKids ($24,000, 2007-2008).
Adolescent Health Care, A Practical Guide, 5th Edition
Pinhas L, Steinegger C, Katzman DK: Clinical
(Neinstein LS, Gordon CM, Katzman DK, Rosen DS,
assessment and physical complications. In:
Development and testing of a self-management
Woods ER, eds.). Philadelphia: Lippincott Williams
Eating Disorders in Childhood and Adolescence,
program for youth post kidney transplant: a Paediatric
and Wilkins, 2007.
3rd Edition (Lask B, Bryant-Waugh R, eds.).
and adult care collaboration. Kidney Foundation
London: Brunner-Routledge, 2007.
of Canada Grant ($90,000, 2008-2010).
Adolescent Health Care LITE (Neinstein LS, Gordon
CM, Katzman DK, Rosen DS, Woods ER, eds.).
Steinegger C: Nutrition. In: Adolescent Medicine:
Development and testing of a self-management
Philadelphia: Lippincott Williams and Wilkins, 2007.
The Requisites in Pediatrics (Slap GD, ed.).
program for youth post kidney transplant: A paediatric
Philadelphia: Mosby Inc., 2008.
and adult care collaboration. Dettmer E, Cullen-Dean
Katzman DK, Golden NE: Eating disorders. In: Adolescent
G, D’Agostino N, Kaufman M, Lorber S, Mitchell M,
Health Care: A Practical Guide, 5th Edition (Neinstein
Schiff J, Pool R. RN Funding Kidney Foundation
L, Gordon C, Katzman DK, Rosen D, Woods E, eds.).
of Canada ($85,134, 2008).
Philadelphia: Lippincott Williams and Wilkins, 2007.
12 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Effects of anorexia nervosa on peak bone mass.
Creating transition clinical pathways. Kaufman M,
Klibanski A, Katzman DK, Misra M, Herzog D,
Cullen-Dean G, Dettmer E, Lorber S, Horricks L.
Levitsky L. National Institute of Health/NIDDK
Sun Life Financial ($25,000, 2008).
($3,801,660, 2003-2008).
Leadership: creating communities of practice for
Faculty development to support capacity building
interprofessional collaboration (IPC) in Toronto.
for interprofessional education. Leslie K, Reeves S,
Kwan D, Leslie K, Lieff S, Nasmith L, Oandasan I.
Silver I, Merkley J, Richardson D, Wagner S, Andrews
Reeves S, Silver I. Ministry of Health and Long-Term
M, Kwan D. Ministry of Health and Long-Term Care
Care Interprofessional, Mentorship, Preceptorship,
($310,000, 2008).
Leadership and Coaching Fund ($1,200,000, 2007).
Family therapy and fluoxetine in the treatment of
Youth with chronic health conditions: tell us how we
adolescent anorexia nervosa. Agras S, Brandt H,
can best teach you self-management skills. Mitchell M,
Halmi K, Johnson C, Kaye W, Wilfley D, Woodside B,
Rivers P, McCurdy C, D’Agostino N, Dettmer E,
Pinhas L, Katzman DK. National Institute of Mental
Cullen-Dean G, Lorber S, Harrison-Kong A, Kaufman M,
Health ($6,250,000 2007-2012).
Pool R. Funding UHN Allied Health Research Award
($1,158, 2008).
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 13
Dr. Edgar Jaeggi
DIVISION HEAD
Dr. Andrew Redington
FULL-TIME
Dr. Lee Benson
Dr. Tim Bradley
Dr. Rajiv Chaturvedi
Dr. Anne Dipchand
Dr. Mark Friedberg
Dr. Fraser Golding
Dr. Gil Gross
Dr. Robert Hamilton
Dr. Edgar Jaeggi
Dr. Paul Kantor
Dr. Joel Kirsh
Dr. Kyong-Jin Lee
Dr. Brian McCrindle
Dr. Luc Mertens
Dr. Seema Mital
Dr. Jennifer Russell
Dr. Elizabeth Stephenson
14 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
PART-TIME
Dr. Tiscar Cavalle-Garrido
Dr. Jack Colman
Dr. Rejane Dillenburg
Dr. Ra Han
Dr. Alexandra Jevremovic
Dr. Anilkumar Menon
Dr. Tapas Mondal
Dr. Norman Musewe
Dr. Lynne Nield
Dr. Erwin Oechslin
Dr. Dionissios Pepelassis
Dr. Rachel Wald
Dr. Roxanne Walker
ADJUNCT
Dr. Fred Keeley
(Research Scientist)
CROSS-APPOINTED
Dr. Desmond Bohn
Dr. Tilman Humpl
Dr. Afrothite Kotsakis
Division of Cardiology
OVERVIEW
multi mode research, investigation and treatment,
and tissue samples will be held for future fundamental,
The Division of Cardiology was formally established in
setting the scene for MRI-guided interventional
translational and clinical research investigations.
the 1940s and is now one of the largest and most
procedures and physiologic measurements in children.
The Royal College accredited Paediatric Cardiology
successful in the world. Its philosophy has remained
unchanged since its inception over 60 years ago: to
The cardiovascular research focus within the Research
Training Program is the largest in Canada and one of
provide the highest quality care in an evidence-based
Institute has made fundamental contributions to our
the largest and most sought after in North America.
environment of clinical innovation and scientific discovery.
Over the past decade, the divisional activities, in
understanding of the cellular biology and molecular
As such, its fellows have populated cardiology groups
genetics of pulmonary vascular bed, with recent
throughout the world, many going on to become
diversification to include the study of the fetal myocyte,
leaders of our specialty.
close collaboration with surgical and intensive care
detailed study of the intercellular structure of the heart
colleagues, have contributed to our markedly improved
and vessels, electrophysiology of the developing heart
The single most important development of the last
preoperative diagnosis and postoperative outcomes
and immunology of cardiac transplantation. While
decade, however, has been the establishment of
for children undergoing cardiac surgery, led the field
undergoing a change in leadership, it is expected that
the Labatt Family Heart Centre. Following a series
in development of therapeutic catheter techniques,
high quality basic and translational research, with an
of important internal initiatives, the extraordinary
made important contributions to our understanding of
emphasis on direct clinical applicability, will continue
generosity of the Labatt family has funded the
fetal cardiac medicine, established one of the largest
to form the bedrock of our academic program. As an
redevelopment and future activities of the Heart
paediatric cardiac transplantation centres worldwide,
example, the Heart Centre is making a major investment
Centre at SickKids.
and has won international recognition for its contribution
in the development of a biobank facility in which DNA
in the field of epidemiology of acquired and congenital
heart disease and surgical outcomes. Each of these
areas has provided the substrate for the large clinical
research output of the division which is underpinned
by a world-class laboratory science program. One of
Dr. Joel Kirsh and patient
the recent exciting clinical developments was the
commissioning of an integrated suite of catheter
laboratories and magnetic resonance scanning
facilities. This unique fusion will allow �simultaneous’
Dr. Steven Schwartz
Dr. Ben Sivarajan
Dr. Shi-Joon Yoo
RESEARCH ASSOCIATES
La Rotta, Gustavo
Dr. Jing Li
CLINICAL FELLOWS
Jaime Alkon
Abdulmajeed Al-Otay
Armando Alfaro-Ramirez
Alexandra Bauch
Jose Castro-Sancho
Robin Clegg
Matthew Crystal
Yousef Etoom
Deborah Fruitman
Brian Grant
Lars Grosse-Wortmann
Damian Hutter
Rubeena Khan
CLINICAL FELLOWS
Anders Nygren
Dragos Predescu
Mark Walsh
Roland Weber
RESEARCH FELLOWS
SUBSPECIALTY RESIDENTS
Christian Apitz
Kentaro Asoh
Jae-Young Lee
Jan MГёller Nielsen
Lucy Roche
Alejandro Floh
Marko Vezmar
Derek Wong
DEPARTMENTAL FELLOW
Ricardo Ayala-Arnez
The Hospital for Sick Children 2007-08 ANNUAL REPORT 15
HONOURS AND AWARDS
Mital S: Roma and Marvin Auerbach Professorship
Golding F: Operational Director of Echocardiography,
(Endowment) in Developmental Biology and Congenital
Mori A, Li J, Liu PP, Redington AN, Coles JC: Early
Cardiology, The Hospital for Sick Children. February,
Heart Research, 2007.
gene expression profiles during intraoperative
Redington A: BMO Financial Group Chair in Cardiology,
Journal of Thoracic and Cardiovascular Surgery 2007:
The Hospital for Sick Children, 2008.
134(1): pp 74-81.
Arab S, Konstantinov IE, Boscarino C, Cukerman E,
myocardial ischemia-reperfusion in cardiac surgery.
2008.
Golding F: Medical Director of Telemedicine,
The Hospital for Sick Children. June, 2008.
Gross G: Schwartz-Reisman Visiting SickKids
Scholarship, The Hospital for Sick Children. 2008.
PUBLICATIONS
Atz AM, Cohen MS, Sleeper LA, McCrindle BW, Lu M,
Akikusa JD, Feldman BM, Gross GJ, Silverman ED,
Prakash A, Breitbart RE, Williams RV, Sang CJ,
Schneider R: Sinus bradycardia following intravenous
Wernovsky G: Functional status of patients with
�pulse’ methylprednisolone. Pediatrics 2007: 119:
Hamilton R: Featured Research, Canadian
pp e778-e782.
heterotaxy syndrome following the Fontan operation.
Cardiology in the Young 2007: 17(2): pp 44-53.
Cardiovascular Congress: abnormal cardiomyocyte
connexin expression in arrhythmogenic right
Akman HO, Sampayo JN, Ross FA, Scott JW, Wilson G,
Bernasconi A, Cavalle-Garrido T, Redington AN:
ventricular cardiomyopathy caused by heterozygous
Benson L, Bruno C, Shanske S, Hardie DG, Dimauro S:
Spontaneous intraoperative ventricular hematoma
desmosomal protein mutations, 2007.
Fatal infantile cardiac glycogenosis with phosphorylase
in a neonate. Heart 2007: 93(8): p 898.
kinase deficiency and a mutation in the gamma
Kantor P: BCCA Leeds 2007 Award for the Best
2-subunit of amp-activated protein kinase. Pediatric
Poster Presentation. “Sudden death of heart disease
Research 2007: 62(4): pp 499-504.
undiagnosed during the lifetime in children: pathology
survey and review of the literature.” British Congenital
Bernheimer J, Friedberg MK, Chan FP, Silverman NH:
Echocardiographic diagnosis of persistent fifth aortic
arch. Echocardiography 2007: 24(3): pp 258-262.
Alsoufi B, Cai S, Williams WG, Coles JG, Caldarone CA,
Cardiac Association (BCCA) Annual Meeting, Leeds,
Redington AM, Van Arsdell GS: Improved results with
Berul CI, Villafane J, Atkins DL, Cecchin F, Kirsh JA,
UK, 2007.
single-stage total correction of Taussig-Bing anomaly.
Johns JA, Kanter RJ, Karpawich PP: Pacemaker lead
European Journal of Cardiothoracic Surgery 2008:
prolapse through the pulmonary valve in children.
Lee J: Promoted to Associate Professor of Paediatrics,
33(2): pp 244-250.
Faculty of Medicine, University of Toronto, 2008.
ADMINISTRATIVE STAFF
Shazia Ali (contract)
Fe Berbano (contract)
Theresa Braggs
Sandra Brisebois
Paula Capela
Tracey Clatworthy (contract)
Esther Delea
Karen Hodgson
Susan Jessop
Shelley Marks
Fran Matthews
Shloka Mirchandaney
Pacing and Clinical Electrophysiology 2007: 30:
pp 1183-1189.
Andrea Morris
Susan Morton
Eleanor Paulino
Robin Smith (contract)
Rooma Vaidya
Denise Vanek
Shirley Wang
Collins KK, Rhee EK, Kirsh JA, Cannon BA, Fish F,
Bharat W, Manlhiot C, McCrindle BW, Pollock-BarZiv
Chaturvedi RR, Redington AN: Pulmonary regurgitation
SM, Dipchand AI: The profile of renal function over
in congenital heart disease. Heart 2007: 93(7):
Dubin A, Van Hare GF: Cryoablation of accessory
time in a cohort of paediatric heart transplant
pp 880-889.
pathways in the coronary sinus in young patients:
a multicenter study from the paediatric and
recipients. Pediatric Transplantation December 18,
2007 [Epub ahead of print].
Cherney D, Miller J, Scholey J, Bradley TJ, Slorach C,
congenital electrophysiology society’s working
Curtis J, Dekker M, Nasrallah R, Hebert R, Sochett E:
group on cryoablation. Journal of Cardiovascular
Electrophysiology 2007: 18: pp 592-597.
Bograd AJ, Mital S, Schwarzenberger JC, Mosca RS,
The effect of cyclooxygenase 2 inhibition on renal
Quaegebeur JM, Addonizio LJ, Hsu DT, Chen JM:
hemodynamic function in humans with Type 1
Twenty-year experience with heart transplantation for
diabetes mellitus. Diabetes 2008: 57(3): pp 688-695.
Bernstein D, Williams GE, Eisen H, Mital S,
1986-2006. American Journal of Transplantation
Cherney DZ, Scholey JW, Nasrallah R, Dekker MG,
Gene expression profiling distinguishes a molecular
2008: 8: pp 2001-2007.
Slorach C, Bradley TJ, HГ©bert RL, Sochett EB, Miller JA.
signature for Grade 1B mild acute cellular rejection
Wohlgemuth JG, Klingler TM, Fang KC, Kobashigawa J:
infants and children with restrictive cardiomyopathy:
Renal hemodynamic effect of cyclooxygenase 2
in cardiac allograft recipients. Journal of Heart
Bradley TJ, Karamlou T, Kulik A, Mitrovic B,
inhibition in young men and women with uncomplicated
Transplantation 2007: 26(12): pp 1270-1280.
Vigneswaran T, Jaffer S, Glasgow PD, Williams WG,
Type 1 diabetes mellitus. American Journal of
Van Arsdell GS, McCrindle BW: Determinants of repair
Physiology–Renal Physiology 2008: 294(6):
type, reintervention, and mortality in 393 children with
pp F1336-F1341.
Davies RR, Russo MJ, Mital S, Martens TM, Sorabella
RS, Hong KN, Gelijins AC, Moskowitz AJ, Quaegebeur
JM, Mosca RS, Chen JM: Predicting survival among
double outlet right ventricle. Journal of Thoracic and
Collins N, Colman J, Benson L, Hansen M, Merchant N,
high-risk paediatric cardiac transplant recipients:
Horlick E: Successful percutaneous treatment of
an analysis of the United Network Organ Sharing
anomalous left coronary artery from pulmonary artery.
Database. Journal of Thoracic Cardiovacular
Cardiac chamber hypertrophy following hematopoietic
International Journal of Cardiology 2007: 122(3):
Surgery 2008: 135(2): pp 147-155.
stem cell transplantation for primary immunodeficiency.
e29-e31.
Cardiovascular Surgery 2007: 134(4): pp 967-973.
Bully SR, Benson L, Grunebaum E, Roifman CM:
Dehghani P, Collins N, Benson L, Horlick E: Role of
Biology of Blood and Marrow Transplantation 2008:
17: pp 229-235.
Collins N, Mehta R, Benson L, Horlick E: Percutaneous
routine radial artery access during aortic coarctation
coronary artery fistula closure in adults: technical
interventions. Catheterization and Cardiovascular
Caldarone CA, Benson L, Holtby H, Li J, Redington AN,
and procedural aspects. Catheterization and
Interventions 2007: 70(4): pp 622-623.
Van Arsdell GS: Initial experience with hybrid palliation
Cardiovascular Interventions 2007: 69: pp 872-880.
for neonates with single-ventricle physiology. Annals
of Thoracic and Cardiovascular Surgery 2007: 84(4):
pp 1294-1300.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 17
Dehghani P, Collins N, Horlick E, Benson L: Chronic
Estes NA 3rd, Page R, Boyden P, Cappato R, Chiu-Man
Friedberg MK, Silverman NH: The systolic to diastolic
pulmonary thromboembolism in a patient with a Fontan
C, Day J, Dimarco J, Ferrick A, Hamdan M, Hamilton R,
duration ratio in children with hypoplastic left heart
circulation: percutaneous management. Catheterization
Hohnloser S, Jung W, Kanter R, Knight B, Lindsay B,
syndrome: a novel doppler index of right ventricular
and Cardiovascular Interventions 2007: 70: pp 893-896.
Natale A, Reynolds D, Rosenbaum D, Saxon L, Shen
function. Journal of the American Society of
WK, Trayanova N, Wilkoff B: Hightlights of heart
Echocardiography 2007: 20(6): pp 749-755.
Dipchand AI, Bharat W, Manlhiot C, Safi M, Lobach NE,
rhythm 2007, The annual scientific sessions of the
McCrindle BW: A prospective study of dobutamine
heart rhythm society, May, 2007: 4(10): pp e1-e9.
Friedberg MK, Silverman NH, Dubin AM, Rosenthal
DN: Mechanical dyssynchrony in children with systolic
stress echocardiography for the assessment of
Freedman SB, Haladyn KJ, Floh A, Kirsh JA, Taylor G, Thull-
dysfunction secondary to cardiomyopathy: a doppler
transplant recipients. Pediatric Transplantation 2008:
Freedman J: Myocarditis: clinical findings and diagnostic
tissue and vector velocity imaging study. Journal of
12: pp 570-576.
evaluation. Pediatrics 2007: 120: pp 1278-1285.
cardiac allograft vasculopathy in pediatric heart
the American Society of Echocardiography 2007:
20(6): pp 756-763.
Dong-Sheng G, Wei-Yi F, Chiu-Man C, Kirsh J, Gross G,
Friedberg MK, Feinstein JA, Rosenthal DN: Noninvasive
Hamilton RM: QT hysteresis in long-QT syndrome
assessment of pulmonary arterial capacitance by
Friedberg MK, Silverman NH, Dubin AM, Rosenthal
children with exercise testing. Chinese Medical
echocardiography. Journal of the American Society of
DN: Right ventricular mechanical dyssynchrony in
Journal 2007: 120: pp 179-82.
Echocardiography 2007: 20(2): pp 186-190.
children with hypoplastic left heart syndrome. Journal
of American Society of Echocardiography 2007: 20(9):
Dutta S, Mihailovic A, Benson L, Kantor PF,
Friedberg MK, Kim N, Silverman NH: Atrioventricular
Fitzgerald PG, Walton JM, Langer JC, Cameron BH:
septal defect recently diagnosed by fetal
pp 1073-1079.
Thoracoscopic ligation versus coil occlusion for
echocardiography: echocardiographic features,
Gengsakul A, Harris L, Bradley TJ, Webb GD, Williams
patent ductus arteriosus: a matched cohort study
associated anomalies and outcomes. Congenital
WG, Siu SC, Merchant N, McCrindle BW: The impact of
of outcomes and cost. Surgical Endoscopy 2008:
Heart Disease 2007: 2(2): pp 110-114.
pulmonary valve replacement after tetralogy of Fallot
Friedberg MK, Roche SL, Balasingam, Stephenson E,
Cardiothoracic Surgery 2007: 32(3): pp 462-468.
repair: a matched comparison. European Journal of
22(7): pp 1643-1648.
Dutta S, Mihailovic A, Benson L, Kantor PF,
Slorach C, Fackoury C, Kantor PF: Evaluation of
Fitzgerald PG, Walton JM, Langer JC, Cameron BH:
mechanical dyssynchrony in children with idiopathic
Gonzalez AMD, Osorio JC, Gruber G, Homma S,
Thoracoscopic ligation versus coil occlusion for
dilated cardiomyopathy and associated clinical
Mital S: Hypertrophy signalling during peripartum
patent ductus arteriosus: a matched cohort study
outcomes. American Journal of Cardiology 2008:
cardiac remodelling. American Journal of Physiology –
of outcomes and cost. Journal of Endovascular
101(8): pp 1191–1195.
Surgery 2008: 22(7): 1643-1648.
18 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Heart and Circulation Physiology 2007: 293(5):
pp H3008-H3013.
Jaeggi E, Chitayat D, Golding F, Kim P, Yoo SJ.
Grosse-Wortmann L, Al-Otay A, Goo HW, Macgowan
Hypertension and Obesity in Youth of the Council on
CK, Coles JG, Benson LN, Redington AN, Yoo SJ:
Cardiovascular Disease in the Young, Council on
Upstairs-downstairs hearts in siblings: prenatal
Anatomical and functional evaluation of pulmonary
Cardiovascular Nursing, Council on Epidemiology and
diagnosis and clinical impact of a rare form of
veins in children by using magnetic resonance imaging.
Prevention, and Council on Nutrition, Physical Activity
congenital malposition of the heart and great arteries.
Journal of the American College of Cardiology 2007:
and Metabolism. Circulation 2007 116(3): pp 344-357.
Cardiology in the Young 2008: 18: pp 337-348.
49: pp 993-1002.
Hickey EJ, Blackstone EH, Lofland GK, Yeh T, Pizarro C,
Jaeggi ET, Friedberg MK. Diagnosis and management
Grosse-Wortmann L, Hamilton R, Yo S-J: Massive
Tchervenkov CI, Pigula F, Overman DM, Jacobs ML,
of fetal bradyarrhythmias. Pacing and Clinical
systemic-to-pulmonary collateral arteries in the setting
Caldarone CA, McCrindle BW: Critical left ventricular
Electrophysiology 2008: 31: pp S50-S53.
of a cavopulmonary shunt and pulmonary venous
outflow tract obstruction: the disproportionate impact
of biventricular repair in borderline cases. Journal of
Jaeggi E, Ryan G, Schmidt M, Chaturvedi RR. Stenting
Thoracic and Cardiovascular Surgery 2007: 134(6):
of the atrial septum in fetal lambs. Ultrasound in
pp 1429-1436.
Obstetrics and Gynecology 2007: 30: p 496.
an argument that cuts both ways. Heart Rhythm
Hickey EJ, McCrindle BW, Blackstone EH, Yeh T, Pigula F,
Karamlou T, Gurofsky R, Bojcevski A, Williams WG,
Journal 2008: 5: pp 716-717.
Clarke D, Tchervenkov CI, Hawkins J, for the CHSS
Caldarone CA, Van Arsdell GS, Paul T, McCrindle BW:
stenosis. Cardiology in the Young 2007: 17: pp 548-550.
Hamilton RM: Genetic testing for mutations or
polymorphisms in sudden infant death syndrome:
Pulmonary Conduit Working Group: Jugular venous
Prevalence and associated risk factors for intervention
valved conduit (contegra) matches allograft performance
in 313 children with subaortic stenosis. Annals of
WG, Smallhorn JF, McCrindle BW: Outcome and
in infant truncus arteriosus repair. European Journal
Thoracic Surgery 2007: 84(3): pp 900-906.
growth potential of left heart structures after neonatal
of Cardiovascular Surgery 2008: 33(5): pp 890-898.
Han RK, Gurofsky RC, Lee KJ, Dipchand AI, Williams
Kaufman BD, Auerbach S, Reddy S, Manlhiot C, Deng L,
intervention for aortic valve stenosis. Journal of
the American College of Cardiology 2007: 50: pp
Horlick EM, McLaughlin PR, Benson LN: The adult with
Prakash A, Printz BF, Gruber D, Papavassiliou D,
2406-2414.
repaired coarctation of the aorta. Current Cardiology
Hsu DT, Sehnertt A, Chung WK, Mital S. RAAS gene
Reports 2007: 9: pp 323-30.
polymorphisms influence progression of pediatric
Helden L, Ross J, Dennison BA, Steinberger J,
Ilina MV, Jaeggi ET, Lee K-J: Neonatal rhabdomyoma
122(5): pp 515-23.
Williams CL: Primary prevention of cardiovascular
causing right ventricular inflow obstruction with
hypertrophic cardiomyopathy. Human Genetics 2007:
Hayman LL, Meininger JC, Daniels SR, McCrindle BW,
disease in nursing practice: focus on children and
duct-dependent pulmonary blood flow: successful
youth. A scientific statement from the American
stenting of PDA. Catheterization and Cardiovascular
Heart Association Committee on Atherosclerosis,
Interventions 2007: 69: pp 881-885.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 19
Krahn AD, Champagne J, Healey JS, Cameron D,
Li J, Zhang G, Cai S, Redington AN: Effect of inhaled
McCrindle BW, Williams RV, Mital S, Clark BJ, Russell
Simpson CS, Thibault B, Mangat I,Tung S, Sterns L,
hydrogen sulfide on metabolic responses in anesthetized,
JL, Klein G, Eisenmann JC: Physical activity levels in
Birnie DH, Exner DV, Parkash R, Sivakumaran S,
paralyzed and mechanically ventilated piglets.
children and adolescents are reduced after the Fontan
Davies T, Coutu B, Cyrstal E, Wolfe K, Verma A,
Pediatric Critical Care Medicine 2008: 9(1): pp 110-112.
Paredes FA, Essebag V: Outcome of the fidelis
procedure, independent of exercise capacity, and are
associated with lower perceived general health. Archives
Stephenson EA, Sanatani S, Gow R, Connors S,
Li J, Zhang G, Herridge J, Holtby H, Humpl T,
of Disease in Childhood 2007: 92(6): pp 509-514.
implantable cardioverter-defibrillator lead advisory:
Redington AN, Van Arsdell GS: Energy expenditure
a report from the Canadian Heart Rhythm Society
and caloric and protein intake in infants following the
Minich LL, Sleeper LA, Atz AM, McCrindle BW, Lu M,
Working Group on device advisories. Heart Rhythm
Norwood procedure. Pediatric Critical Care Medicine
Colan SD, Printz EF, Klein GL, Sundel RP, Takahashi M,
2008: 5: pp 639-642.
2008: 9(1): pp 55-61.
Li JS, Vetter VL, Newburger JW: Delayed diagnosis
of Kawasaki disease: what are the risk factors?
Lacro RV, Dietz HC, Wruck LM, Bradley TJ, Colan SD,
Li J, Zhang G, Holtby H, Guerguerian AM, Cai S, Humpl
Devereux RB, Klein GL, Li JS, Minich LL, Paridon SM,
T, Caldarone CA, Redington AN, Van Arsdell GS: The
Pediatrics 2007: 120(6): pp e1434-e1440.
Pearson GD, Printz BF, Pyeritz RE, Radojewski E,
influence of systemic hemodynamics and oxygen
Moola F, Faulker GEJ, Kirsh JA, Kilburn J: Physical
Roman MJ, Saul JP, Stylianou MP, Mahony L, for the
transport on cerebral oxygen saturation in neonates
activity and sport participation in youth with congenital
Pediatric Heart Network Investigators: Rationale and
after the Norwood procedure. Journal of Thoracic
heart disease: perceptions of children and parents.
design of a randomized clinical trial of beta-blocker
Cardiovascular Surgery 2008: 135(1): pp 83-90.
Adapted Physical Activity Quarterly 2008: 25: pp 49-70.
therapy (atenolol) versus angiotensin II receptor
blocker therapy (losartan) in individuals with Marfan
McCrindle BW, Li JS, Minich LL, Colan SD, Atz AM,
Nelken J, Meshkani R, Chahal N, McCrindle BW, Adeli K:
syndrome. American Heart Journal 2007: 154(4):
Takahashi M, Vetter VL, Gersony WM, Mitchell PD,
Detection of familial defective apoB (FDB) mutations in
pp 624-631.
Newburger JW, for the Pediatric Heart Network
hypercholesterolemic children and adolescents by
Investigators: Coronary artery involvement in children
denaturing high performance liquid chromatography
Li J, Zhang G, Benson L, Holtby H, Cai S, Humpl T,
with Kawasaki disease: risk factors from analysis of
(DHPLC). Clinical Biochemistry 2008: 41(6): pp 395-399.
Van Arsdell GS, Redington AN, Caldarone CA:
serial normalized measurements. Circulation 2007:
Comparison of the profiles of postoperative systemic
116(2): pp 174-179.
Nielsen JM, Kristiansen SB, Ringgaard S, Nielsen TT,
the hybrid or the Norwood procedure: a pilot study.
McCrindle BW, McIntyre S, Kim C, Lin T, Adeli K:
volume measurement in mice by conductance
Circulation 2007: 116(11 Suppl): pp 179-187.
Are patients after Kawasaki disease at increased
catheter. Evaluation and optimization of calibration.
risk for premature cardiovascular disease? Journal
American Journal of Physiology - Heart and Circulatory
of Pediatrics 2007: 151(3): pp 244-248.
Physiology 2007: 293(1): H534-H540.
Flyvbjerg A, Redington AN, Botker HE: Left ventricular
hemodynamics and oxygen transport in neonates after
20 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Roche SL, Kaufman J, Dipchand AI, Kantor PF:
Osaki M, Caldarone CA, Dipchand AI: Extended aortic
Pollock-BarZiv SM, McCrindle BW, West LJ,
dissection following aortic cannulation in an infant.
Dipchand AI: Waiting before birth: outcomes after
Hypertension after pediatric heart transplantation is
Pediatric Cardiology 2008: 29: pp 232-233.
fetal listing for heart transplantation. American
primarily associated with immunosuppressive regimen.
Journal of Transplantation 2008: 8: pp 412-418.
The Journal of Heart and Lung Transplantation 2008:
5: pp 501-507.
Osaki M, McCrindle BW, Van Arsdell GS, Dipchand AI:
Anomalous origin of a coronary artery from the
Pollock-BarZiv SM, McCrindle BW, West LJ, Manhliot C,
opposite sinus of valsalva with an interarterial course:
Vanderliet M, Dipchand AI: Competing outcomes after
Roman KS, Fouron JC, Nii M, Smallhorn JF,
clinical profile and approach to management in the
neonatal and infant wait-listing for heart transplantation.
Chaturvedi R, Jaeggi ET: Determinants of outcome in
pediatric population. Pediatric Cardiology 2008:
Journal of Heart and Lung Transplantation 2007: 26:
fetal pulmonary valve stenosis or stresia with intact
29(1): pp 24-30.
pp 980-985.
ventricular septum. American Journal of Cardiology
2007: 99: pp 699-703.
Ozawa A, Chaturvedi R, Lee KY, Benson L: Femoral
Reid GJ, Siu SC, McCrindle BW, Irvine MJ, Webb GD:
Saul JP, Epstein AE, Silka MJ, Berul CI, Dick M,
vein hemostasis in children using a suture-mediated
Sexual behaviour and reproductive concerns among
device. Journal of Interventional Cardiology 2007:
adolescents and young adults with congenital heart
DiMarco JP, Friedman RA, Rosenthal E, Stephenson EA,
20: pp 164-167.
disease. International Journal of Cardiology 2008:
Vetter VL: Clinical competency statement: training
125(3): pp 332-338.
pathways for implantation of cardioverter-defibrillators
and cardiac resynchronization devices in pediatric
Pihkala J, Yazaki S, Mehta R, Lee KJ, Chaturvedi R,
Reid GJ, Webb GD, McCrindle BW, Irvine MJ, Siu SC:
and congenital heart patients. Heart Rhythm Journal
clinical impact of transcatheter closure of interatrial
Health behaviors among adolescents and young
2008: 5(6): pp 926-933.
communications after a fenestrated Fontan
adults with congenital heart disease. Congenital
procedure: medium-term outcomes. Catheterization
Heart Disease 2008: 3(1): pp 16-25.
Soslow JH, Friedberg MK, Silverman NH. Idiopathic
Richmond ME, Addonizio LJ, Hsu DT, Mital SR, Mosca
an indication for early delivery. Echocardiography
Pollock-BarZiv SM, den Hollander N, Ngan BY,
RS, Quaegebeur JM, Chen J, Lamour, JM: Cardiac
2008: April 8 [E-pub ahead of print].
Kantor P, McCrindle BW, Dipchand AI: Pediatric heart
retransplantation in high-risk pediatric patients.
transplantation in HLA-sensitized patients: evolving
Pediatric Transplantation 2007: 11: pp 615-623.
McCrindle BW, Arsdell GV, Benson LN. Feasibility and
premature closure of the ductus arteriosus:
and Cardiovascular Intervention 2007: 69: pp 1007-1014.
Stephenson EA, Berul CI: Electrophysiologic
management and assessment of intermediate-term
interventions for inherited arrhythmia syndromes.
outcomes in a high-risk population. Circulation 2007:
Circulation 2007: 116: pp 1062-1080.
116(11 Suppl): pp 1172-1178.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 21
Suto F, Zhu W, Chan A, and Gross GJ: IKr and
Wong D, Benson LN, Van Arsdell GS, Karamlou T,
Dodd DA, Cabo J, Dipchand AI: Acute rejection:
IKs remodelling differentially affects QT interval
McCrindle BW: Balloon angioplasty is preferred
natural history, risk factors, surveillance, and
prolongation and dynamic adaptation to heart rate
to surgery for aortic coarctation. Cardiology in the
treatment. In: ISHLT Monograph Series Pediatric
acceleration in bradycardic rabbits. American Journal
Young 2008: 18: pp 79-88.
Heart Transplantation (Canter CE, Kirklin J, eds.).
Philadelphia: Elsevier, 2008.
of Physiology – Heart and Circulatory Physiology
2007: 292: pp H1782-H1788.
Zhu Y, Gramolini AO, Walsh MA, Zhou YQ, Slorach C,
Friedberg MK, Takeuchi JK, Sun H, Hendelman RM,
Friedberg MK, Silverman NH, Hanley FL, Mohan RV,
Vogt KN, Manlhiot C, Van Arsdell G, Russell JL, Mital
Backx PH, Redington AN, Maclennan DH, Bruneau BG:
Albanese CT: Fetal cardiac intervention. In:
S, McCrindle BW. Somatic growth in children with
Tbx5-dependent pathway regulating diastolic function in
Hemodynamics and Cardiology: Neonatology
single ventricle physiology: Impact of physiologic state.
congenital heart disease. Proceedings of the National
Questions and Controversies (Kleinman CS and
Journal of the American College of Cardiology 2007:
Academy of Science USA 2008: 105(14): pp 5519-5524.
Seri I, eds.). Philadelphia: Saunders/Elsevier, 2008.
BOOK CHAPTERS
Redington AR: Cardiopulmonary and right-left heart
50(19): pp 1876-1883.
Walsh MA, Benson LN, Dipchand AI, Redington AN,
Benson L: Pulmonary vein stenosis. In: Percutaneous
interactions. In: Moss and Adam’s Heart Disease in
Caldarone CA, Van Arsdell GS, Kantor PF: Surgical
Interventions for Congenital Heart Disease (Sievert H,
Infants, Children and Adolescents (Including the Fetus
repair of the mitral valve in children with dilated
Qureshi S, Wilson N, Hijazi Z, eds.). London: Informa
and Young Adult), 7th Edition (Allen HD, Driscoll DJ,
cardiomyopathy and mitral regurgitation. Annals
Healthcare, 2007.
Shaddy RE, Feltes TF, eds.). Philadelphia: Wolters
Kluwer Lippincott Williams & Wilkins, 2008.
of Thoracic Surgery 2008: 85: pp 2085-2088.
Benson L, Mikailian H: Imaging modalities in the
Walsh MA, Lee K-J, Chaturvedi R, Van Arsdell GS,
cath lab: angiography. In: Percutaneous Interventions
Webb GD, Smallhorn JF, Therrien J, Redington AN:
Benson LN: Radiofrequency perforation of right
for Congenital Heart Disease (Sievert H, Qureshi S,
Congenital heart disease. In: Braunwald’s Heart
ventricular outflow tract as a palliative strategy
Wilson N, Hijazi Z, eds.). London: Informa Healthcare,
Disease: A Textbook of Cardiovascular Medicine, 8th
for pulmonary atresia wiht ventricular septal defect.
2007, pp 15-32.
Edition (Libby P, Bonow RP, Mann DL, Zipes D, eds.).
Catheterization and Cardiovascular Interventions
2007: 69: pp 1015-1020.
Philadelphia: Saunders Elsevier, 2007.
Dipchand AI: HSC mismatch protocol. In: Paediatric
heart transplantation - en handledning for vardgivare
Yoo SJ, Jaeggi E. Ultrasound evaluation of the
(Gilljam T, ed.). Goteborg: Sahlgrenska
fetal heart. In: Ultrasonography in Obstetrics and
Universitetssjukhuset, 2008.
Gynaecology, 5th Edition (Callen P, ed.) Philadelphia:
Saunders Elsevier, 2008.
22 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
FUNDING
Characterisation of circulating effectors and temporal
Contractile adaptations to constrained heart rate
A randomized, double-blind, multi-centre study of
profiling of remote ischaemic preconditioning. Redington AN,
conditions. Gross GJ, Redington AN. Canadian
antiarrhythmic medications in the treatment of infants
Callahan J, Gross G, Kharbanda R. Canadian Institutes
Institutes of Health Research ($529,180 2008-2012).
with supraventricular tachycardia (SAMIS Trial).
of Health Research ($324,951 2006-2009).
Contractile and electrophysiologic adaptations
Shubhayan S, Stephenson E, Potts J, Etheridge S.
to constrained heart rate conditions. Gross GJ,
Heart and Stroke Foundation of Canada
Canadian Institutes of Health Research Team in
($444,060 2006-2010).
Childhood Obesity Research. Anderson H, Hamilton J,
Redington AN. Heart and Stroke Foundation
Parkin P, Pencharz P. Canadian Institutes of Health
of Ontario ($209,097 2006-2008).
A transatlantic network for the investigation of remote
Research ($2,452,522 2008-2013).
Contribution of three-dimensional echocardiography to
ischemic preconditioning. Redington AN, McCrindle BW,
Callahan J, Wilson G, Caldarone C, Kharbanda R,
Clinical and genomic responses to remote ischemic
surgery for left ventricular outflow tract obstruction
Botker HE, Neilsen TT. Leducq Foundation
preconditioning. Redington A, Arab S, Coles J, Holtby H,
in children. Friedberg MK, Van Arsdell G, Calderone C,
Liu P, Schwartz S, Van Arsdell G. National Heart, Lung,
Coles J, Golding F, Bradley TJ, Gooi A. The Hospital
($6,800,000 2006-2011).
Biventricular pacing in children after surgery for
and Blood Institute/National Institutes of Health
for Sick Children Paediatric Consultants Partnership
($2,047,004 US 2006-2011).
($9,819 2007-2008).
congenital heart disease. Friedberg M, Stephenson EA.
Labatt Family Heart Centre Innovations Funding
Clinical and laboratory evaluation of acute rejection,
Creating a fetal lamb model of hypoplastic left heart
($15,000 2007-2009).
myocyte growth, repair and oxidative stress following
syndrome. Chaturvedi R, Jaeggi E. Labatt Family
de novo cardiac transplant: a comparison between
Heart Centre ($21,000 2008).
Cardiac gene bank. Mital S, Hamilton R, Coles J.
tacrolimus- and cyclosporine-based immunprophylactic
Labatt Heart Centre Fund ($100,000 2008-2010).
regimens with mycophenolic acid therapeutic drug
CTOT-C (Clinical Trials in Organ Transplantation
monitoring. Dipchand AI, Pollock BarZiv S, Allain-
in Children) 1U01AI077867-01: Alloantibodies in
Cardiac transplantation in infancy – exploring the
Rooney T, Kantor PF. Astellas Pharma Canada Inc.
cardiac transplantation: Intervention, outcomes
implication for the immune system. Platt J, West L,
($65,000 2006-2008).
and mechanisms. Webber S, Dipchand AI, Blume E,
Canter C, Naftel D, Hsu D. National Institutes of
Cascalho M. National Heart, Lung, and Blood
Institute/National Institutes of Health
Clinial characteristics and psychological health
($7,100,942 US 2005-2010).
of Canadian children with implantable cardioverter
Health ($5,205,958 2008-2013).
defibrillators. Stephenson EA, Conway J, Chiu-Man C,
Mendlowitz S. Labatt Family Heart Centre
Innovations Funding ($10,731 2008-2009).
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 23
Identifying factors involved in the prenatal diagnosis
Individualized heparin and protamine management
Late functional status in a cohort of survivors with
of congenital heart defects requiring neonatal
in infants undergoing cardiopulmonary bypass
pulmonary atresia intact ventricular septum from the
intervention. Dutil N, Jaeggi E. Labatt Family Heart
for cardiac surgery reduces bleeding and blood
Congenital Heart Surgeons Society study. Caldarone C.
transfusion requirements. Guenwald C, Chan A,
Children’s Heart Foundation ($89,190 US 2007-2008).
Centre ($18,600 2008-2009).
Van Arsdell G, Holtby H. Heart and Stroke
Effects of remote ischemic preconditioning on clinical
Foundation of Canada ($108,566 2006-2008).
Molecular expression and physiology in developing
atrioventricular nodal cells. Hamilton RM, Gross GJ,
and genomic responses to open heart surgery in
children. McCrindle BW, Redington A. Canadian
Inflammation and atherosclerosis in paediatric
Silverman ED. Canadian Institutes of Health
Insititutes of Health Research ($100,000 2007-2008).
rheumatic disease. Bradley TJ, Beyene J, Schneider R,
Research ($370,500 2006-2009).
Effects of right ventricular intraventricular mechanical
Centre - Innovation Fund ($12,000 2007-2008).
Feldman B, Silverman ED. Labatt Family Heart
Optimizing health among children with congenital
heart defects through rehabilitation focused on physical
dyssynchrony on right and left ventricular dysfunction
activity determinants. McCrindle BW, Russell JL,
in tetralogy of Fallot. Friedberg M, Redington A,
Inflammation and atherosclerosis in paediatric
Yoo S-J, Stephenson E, Russell J, Kantor P, Roche L.
rheumatic disease. Bradley TJ, Beyene J, Schneider R,
Dettmer E, Longmuir P. Heart and Stroke Foundation
National Grants Program, SickKids Foundation,
Feldman B, Silverman ED. Heart and Stroke
of Canada ($208,928 2007; $616,465 2008-2011).
and Canadian Institutes of Health Research
Foundation of Ontario ($125,448 2007-2009).
Outcome of paediatric patients with cardiomyopathy:
($108,766 2007-2009).
Intercalated disc potein expression in arrhythmogenic
a multicentre review of paediatric patients listed for
Genetics of heart disease in children. Mital S.
right ventricular cardiomyopathy. Hamilton RM,
transplant in the paediatric Heart Transplant Study
Labatt Family Heart Centre Innovation Fund
Chauhan V, Scherer S. Heart and Sroke
Group. Dipchand AI, Hsu D, Naftel D. Children’s
($200,000 per year 2007-2010).
Foundation of Ontario ($72,100 2008-2010).
Cardiomyopathy Foundation ($21,321 2007-2008).
HLA sensitization: prevalence and impact of
Intrauterine growth retardation associated with and
Perioperative use of thymoglobulin in paediatric heart
alloantibodies in paediatric heart transplant recipients.
without placental insufficiency: impact on myocardial
transplant recipients. Dipchand AI, Pollock-BarZiv SM,
Dipchand AI, Pollock-Barziv S, McCrindle BM. The
function and on arterial compliance. Jaeggi ET,
Allain-Rooney T, Kantor PF. Genzyme Canada ($5,000
Hospital for Sick Children Paediatric Consultants
Bradley TJ, Keating SJ, Kingdom JCP. Heart and
2006-2007).
Partnership ($10,000 2007 - 2008).
Stroke Foundation of Ontario ($77,255 2006-2008).
24 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Prevention, detection and management of
Temporal profiling and circulating effectors of remote
Validation of accelerometry as a measure of physical
thromboembolic complications after paediatric cardiac
ischaemic preconditioning. Redington A, Callahan J.
activity and inactivity in children with chronic disease.
surgery: toward evidence-based clinical protocols.
Canadian Institutes of Health Research ($284,000
Feldman B, Stephens S, Takken T, Wright V, Tremblay M,
Manlhiot C, Gruenwald C, Brandao L, Chan AK,
2005-2008).
Eslinger D, Beyene J, Walker-Schneiderman J, Biggar
W, Longmuir P, Vandernet J. Canadian Institutes of
Schwartz S, Holtby H, Sivarajan B, Van Arsdell G,
Caldarone C, Clarizia N, Crawford-Lean L. Labatt
The effect of remote ischemic preconditioning on
Family Heart Centre Innovations Fund ($29,210 2008).
clinical and genetic responses to open heart surgery
Right ventricular versus modified blalock-taussig shunt
Health Research ($65,000 2007-2008).
in children. Redington A. Canadian Institutes of
Ventricular function and arterial stiffness in the
Health Research ($97,360 2007-2008).
evaluation of paediatric heart failure. Kantor PF,
Bradley TJ, Roche SL, Slorach C. The Hospital
in infants with single ventricle defect undergoing
staged reconstruction. McCrindle BM, Site PI, in a
The effectiveness of low fat breast milk for the
for Sick Children Paediatric Consultants
multicentre networked collaboration. National Heart,
treatment of chylothorax in infants following
Partnership ($7,200 2007-2008).
Lung, and Blood Institute/National Institutes of
cardiothoracic surgery: a pilot study. Farmer S, Russell
Health ($300,000 2005-2008).
JL, O’Connor D. Labatt Heart Centre Innovation Fund
Ventricular repolarization in complete heart block.
($24,000 2007).
Gross GJ. Heart and Stroke Foundation of Ontario
($208,406 2004-2007).
Role of chronic inflammation and systemic lupus
erythematosus-related factors in the development
The role of traditional and non-traditional risks in the
of premature atherosclerosis in paediatric SLE.
development of atherosclerosis in paediatric systemic
Silverman ED, Bargman JM, Beyene J, Bradley TJ. Heart
lupus erythematosus. Silverman E, Adeli K, Bargman J.
remodelling. Gross GJ. Heart and Stroke Foundation
and Stroke Foundation of Ontario ($275,000 2006-2009).
Heart and Stroke Foundation of Ontario ($163,454
of Ontario ($268,447 2007-2010).
Ventricular repolarization in bradycardic electrical
2003-2008).
Very high resolution vascular imaging in children
RSV immunoprophylaxis in children with congenital
heart disease. Lee K-J, Cranis M, Allen U, James A,
The SAMIS Trial: multicentre study of antiarrhythmic
with normal and abnormal vascular development
O’Brien K, Simmons B, Dennis M, Bracht M, O’Doherty B.
medications for treatment of infants with supraventricular
and maturation. Sarkola T, Jaeggi E, Redington A.
Abbott Laboratories ($71,482 2006-2007).
tachycardia. Sanatani, S, Stephenson EA, McCrindle BM,
Societatis Medicorum Fennicae (ВЈ20,000 salary
Potts J, Etheridge S. Heart and Stroke Foundation of
support for Dr. Sarkola) Instrumentarium Foundation
British Columbia and Yukon ($440,060 2006-2010).
(ВЈ50,000); The Finnish Cultural Foundation ВЈ20,000)
RSV immunoprophylaxis in children with congenital
heart disease. Lee K-J, Cranis M, Allen U, James A,
(2008-2009).
O’Brien K, Simmons B, Dennis M, Bracht M,
O’Doherty B. Abbott Industries ($82,217 2007-2008).
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 25
Dr. Rosanna Weksberg
DIVISION HEAD
Dr. Rosanna Weksberg
FULL-TIME
Dr. David Chitayat
Dr. Annette Feigenbaum
Dr. Roberto Mendoza
Dr. Julian Raiman
Dr. Andreas Schulze
Dr. Grace Yoon
PART-TIME
Dr. Karen Chong
Dr. Joe Clarke
Dr. Leona Fishman
Dr. Stephen Meyn
Dr. Ahmad Teebi
CLINICAL FELLOWS
Dr. Fatma Al-Jasmi
Dr. Fathiya Al-Murshedi
Dr. Christopher Barnett
Dr. Brian Chung
Dr. Ellen Crushell
Dr. Arie Koifman
Dr. Gustavo Maegawa
Dr. Sandhya Parkash
RESIDENTS
Dr. Hanna Faghfoury
Dr. Jane Gillis
Dr. Elaine Goh
Dr. Sharan Goobie
Division of Clinical and Metabolical Genetics
OVERVIEW
newborn period. SickKids is one of five regional
established to honour Dr. Opitz, the founding
The Division of Clinical and Metabolic Genetics
newborn screening centres and is the largest in the
editor-in-chief of the American Journal of Medical
provides excellent clinical care, and supports a variety
province. Dr. Andreas Schulze was recently appointed
Genetics. The awardee is selected for a significant
of clinical, research, educational and administrative
the Medical Director of the Newborn Screening
research paper published in the previous year in the
programs. An important new endeavour is the Ontario
Program. The program at SickKids is co-ordinated with
American Journal of Medical Genetics in the areas of
Genetics Secretariat (OGS). The Secretariat was
the Division of Clinical and Metabolic Genetics and is
congenital anomalies, mechanisms of morphogenesis
generated by a Department of Paediatrics invitation
supported by an interdisciplinary team.
and malformations, or developmental biology.
The support of this initiative by CHS and the Hospital
Research endeavors in the division are a vital part of
The seventh annual Starbucks Clinical Research
to support province-wide subspecialty initiatives.
Executive has been instrumental in its success.
our program and currently focus on the translation of
Summer Students Competition was awarded to
The OGS is chaired by Christopher Carew from
new genomic information for patients and their families.
Laura White for a study on bone marrow transplantation
SickKids and has representation from all the clinical
The use of microarrays for genetic testing continues to
in Mucopolysaccaridosis type I (Hurler Disease).
She was supervised by Dr. Julian Raiman.
genetics programs and genetic diagnostic laboratories
increase.The large influx of genomic data for many of
across Ontario. The mandate of OGS is to develop a
our patients has impacted our pattern of practice.
collaborative and integrated approach to negotiations
There are many new challenges in the interpretation of
with the Ontario Ministry of Health and Long-Term
entirely novel data in the clinical setting.
developed and participated in numerous educational
activities within the hospital. It has important links to
Care for resourcing genetic services.
The DNA Resource Centre Program has continued to
The Division of Clinical and Metabolic Genetics has
Dr. Grace Yoon received the John M. Opitz Young
the Research Institute and the Department of Paediatric
Investigator Award in the fall of 2007. This award was
Laboratory Medicine. The division directs fellowship
provide up-to-date information regarding genetic
testing available nationally and internationally, and
ensures that all patients at SickKids have access to
cutting-edge genetic testing.
Drs. Roberto Mendoza,
David Chitayat and team
In 2006, the MOHLTC embarked on major changes to
newborn screening. Twenty-six additional disorders
(endocrine, genetic metabolic, hemoglobinopathies
and cystic fibrosis) are now screened for in the
RESIDENTS
Dr. Shailly Jain
Dr. Linda Kim
Dr. Joyce So
Dr. Mohammad Yaghoobi
ADMINISTRATIVE STAFF
Jennifer Costa
Michael Delaney
Susan Dukhedlin-Lalla
Laurie Furtado
Kamalina Gupta
Denese Henry
Andrea Jonker
Melanie Lameront
Tina McConkey
Natalie Sargeant
Deb Taylor
Rozmin Visram
and residency training programs in genetic medicine
Briggs TA, Abdel-Salam GM, Balicki M, Baxter P,
Demuth I, Bradshaw PS, Lindner A, Anders M,
as well as the MSc Program in Genetic Counselling.
Bertini E, Bishop N, Browne BH, Chitayat D,
Heinrich S, Kallenbach J, Schmelz K, Digweed M,
Chong WK, Eid MM, Halliday W, Hughes I,
Meyn MS, Concannon P: Endogenous hSM1B/Apollo
HONOURS AND AWARDS
Klusmann-Koy A, Kurian M, Nischal KK, Rice GI,
interacts with TRF2 and stimulates ATM in response
Yoon G: John M. Opitz Young Investigator Award, 2007.
Stephenson JB, Surtees R, Talbot JF, Tehrani NN,
to ionizing radiation. DNA Repair 2008: May 9
Tolmie JL, Toomes C, van der Knaap MS, Crow YJ:
[Epub ahead of print].
PUBLICATIONS
Cerebroretinal microangiopathy with calcifications
Auray-Blais C, Cyr D, Ntwari A, West ML,
and cysts (CRMCC). American Journal of Medical
Footitt EJ, Sinha MD, Raiman JA, Dhawan A,
Cox-Brinkman J, Bichet DG, Germain DP,
Genetics, Part A 2008: 146(2): pp 182-190.
Moganasundram S, Champion MP: Mitochondrial
Clarke JTR, Drouin R: Urinary globotriaosylceramide
Brunetti-Pierri N, Doty SB, Hicks J, Phan K,
and review. British Journal of Anaethesia 2008:
excretion correlates with the genotype in children
Mendoza-Londono R, Blazo M, Tran A, Carter S,
100(4): pp 436-441.
disorders and general anaesthesia: a case series
Laframboise R, Melançon SB, Stockley T,
and adults with Fabry disease. Molecular Genetics
Lewis R, Plon S, Phillips W, Smith EO, Ellis K, Lee, B:
and Metabolism 2008: 93: pp 331-340.
Generalized metabolic bone disease in Neurofibromatosis
Greer KJ, Kirkpatrick SJ, Weksberg R, Pauli RM:
type 1. Molecular Genetics and Metabolism 2008:
Beckwith-Wiedemann syndrome in adults:
94(1): pp 105-111.
observations from one family and recommendations
Bähring S, Kann M, Neuenfeld Y, Gong M, Chitayat D,
for care. American Journal of Medical Genetics.
Toka HR, Toka O, Plessis G, Maass P, Rauch A, Aydin A,
Luft FC: Inversion region for hypertension and
Clarke JTR, West M, Bultas J, Schiffmann R: The
Part A 2008: 146A(13): pp 1707-1712.
brachydactyly on chromosome 12p features multiple
pharmacology of multiple regimens of agalsidase
splicing and noncoding RNA. Hypertension 2008:
alfa enzyme replacement therapy for Fabry disease.
Hadzi N, Vara R, Raiman J, Mieli-Vergani G:
51(2): pp 426-431.
Genetic Medicine 2007: 9: pp 504-509.
Old versus new antiepileptic drugs: The SANAD study.
Lancet 2007: 370(9584): p 315.
Beauchamp NJ, Dalton A, Ramaswami U, Niinikoski H,
Mention K, Kenny P, Kolho KL, Raiman J, Walter J,
Treacy E, Tanner S, Sharrard M: Glycogen storage
disease type IX: high variability in clinical phenotype.
Molecular Genetics and Metabolism 2007: 92(1-2):
pp 88-99.
28 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Jaeggi E, Chitayat D, Golding F, Kim P, Yoo SJ:
Lindner M, Abdoh G, Fang-Hoffmann J, Shabeck N,
McCready ME, Carson NL, Chakraborty P, Clarke JT,
Prenatal diagnosis of topsy-turvy heart. Cardiology
Al-Sayrafi M, Al-Janahi M, Ho S, Abdelrahman MO,
Callahan JW, Skomorowski MA, Chan AK, Bamforth F,
in the Young 2008: 18(3): pp 337-342.
Ben-Omran T, Bener A, Schulze A, Al-Rifai H, Al-Thani G,
Casey R, Rupar CA, Geraghty MT: Development of a
Hoffmann GF: Implementation of extended neonatal
clinical assay for detection of GAA mutations and
Kepron C, Blumenthal A, Chitayat D, Cutz E,
screening and a metabolic unit in the State of Qatar:
characterization of the GAA mutation spectrum in a
Superti-Furga A, Keating S. An autophagic vacuolar
developing and optimizing strategies in co-operation
Canadian cohort of individuals with glycogen storage
myopathy-like disorder presenting as non-immune
with the Neonatal Screening Center in Heidelberg.
disease, type II. Molecular Genetics and Metabolism
hydrops in a female fetus. Pediatric and Developmental
Journal of Inherited Metabolic Disease 2007: 30(4):
2007: 92: pp 325-335.
Pathology 2008: February 25 [Epub ahead of print].
pp 522-529.
Konen O, Armstrong D, Clarke H, Padfield N,
Marshall CR, Noor A, Vincent JB, Lionel AC, Feuk L,
Napierala D, Scott DA, Sibai T, Casas K, Wilson P,
Weksberg R, Blaser S: C1-2 vertebral anomalies
Skaug J, Shago M, Moessner R, Pinto D, McAuliffee F,
Lee J, Muneer R, Leonard JC, Ramji FG, Lachman R,
in 22q11.2 microdeletion syndrome. Pediatric
Chitayat D, Halliday W, Keating S, Shah V,
Li S, Stankiewicz P, Lee B, Mulvihill JJ: De novo
Radiology 2008: 38(7): pp 766-771.
Fink M, Nevo O, Ryan G, Shannon P, Blaser S:
three-way chromosome translocation 46, XY, t
Rhombencephalosynapsis: prenatal imaging and
(4;6;21)(p 16; p 21.1; q21) in a male with
Levy HL, Milanowski A, Chakrapani A, Cleary M,
autopsy findings. Ultrasound in Obstetrics and
cleidocranial dysplasia. American Journal of Medical
Lee P, Trefz FK, Whitley CB, Feillet F, Feigenbaum AS,
Gynaecology 2008: 3(5): pp 542-548.
Genetics 2008: 146(4): pp 453-8.
Purandare SM, Mendoza-Londono R, Yatsenko SA,
Bebchuk JD, Christ-Schmidt H, Dorenbaum A,
Sapropterin Research Group: Efficacy of sapropterin
Marshall C, Noor A, Vincent J, Lionel A, Feuk L,
Ren Y, Thiruvahindrapduram B, Fiebig A, Schreiber S,
dihydrochloride (tetrahydrobiopterin, 6R-BH4) for
Skaug J, Shago M, Moessner R, Pinto D, Ren Y,
Friedman J, Ketelaars CE, Vos YJ, Ficicioglu C,
reduction of phenylalanine concentration in patients
Thiruvahindrapduram B, Fiebig A, Schreiber S,
Kirkpatrick S, Nicolson R, Sloman L, Summers A,
with phenylketonuria: a phase III randomised
Friedman J, Ketelaars CEJ, Vos YJ, Ficicioglu C,
Gibbons CA, Teebi A, Chitayat D, Weksberg R,
placebo-controlled study. Lancet 2007: 370(9586):
Kirkpatrick S, Nicholson R, Sloman L, Summers A,
Thompson A, Vardy C, Crosbie V, Luscombe S,
pp 504-510.
Gibbons C, Teebi A, Chitayat D, Weksberg R,
Baatjes R, Zwaigenbaum L, Roberts W, Fernandez B,
Thompson A, Vardy C, Crosbie V, Luscombe S,
Szatmari P, Scherer SW: Structural variation of
Baatjes R, Zwaigenbaum L, Roberts W, Fernandez B,
chromosomes in autism spectrum disorder. American
Szatmari P, Scherer S: Structural variation of
Journal of Human Genetics 2008: 82(2): pp 477-488.
chromosomes in autism spectrum disorder. American
Journal of Human Genetics 2008: 82(2): pp 477-488.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 29
Spitzer RF, Wherrett D, Chitayat D, Colgan T, Dodge JE,
Robinson AJ, Blaser S, Toi A, Chitayat D, Halliday W,
Sermer D, Quercia N, Chong K, Chitayat D: Acrofacial
Pantazi S, Gundogan M, Laughlin S, Ryan G: The fetal
dysostosis syndrome type Rodriguez: prenatal diagnosis
Salle JL, Allen L: Maternal luteoma of pregnancy
cerebellar vermis: assessment for abnormal development
and autopsy findings. American Journal of Medical
presenting with virilization of the female infant.
by ultrasonography and magnetic resonance imaging.
Genetics. Part A 2007: 143(24): pp 3286-3289.
Journal of Obstetrics and Gynaecology Canada 2007:
29(10): pp 835-840.
Ultrasound Quarterly 2007: 23(3): pp 211-223.
Smith AC, Shuman C, Chitayat D, Steele L, Ray PN,
Rela M, Battula N, Madanur M, Mieli-Vergani G,
Bourgeois J, Weksberg R: Severe presentation of
Stachon AC, Baskin B, Smith AC, Shugar A,
Dhawan A, Champion M, Raiman J, Heaton N: Auxiliary
Beckwith-Wiedemann syndrome associated with high
Cytrynbaum C, Fishman L, Mendoza-Londono R,
liver transplantation for propionic academia. American
levels of constitutional paternal uniparental disomy for
Klatt R, Tebbi A, Ray PN, Weksberg R: Molecular
Journal of Transplantation 2007: 7(9): pp 2200-2203.
chromosome 11p15. American Journal of Medical
diagnosis of 22q11.2 deletion and duplication by
Genetics. Part A 2007: 143(24): pp 3010-3015.
multiplex ligation dependent probe amplification.
American Journal of Medical Genetics. Part A 2007:
Revencu N, Boon LM, Mulliken JB, Enjolras O,
Crodisco MR, Burrows PE, Clapuyt P, Hammer F,
Smith AC, Choufani S, Ferreira JC, and Weksberg R:
Dubois J, Baselga E, Brancati F, Carder R, Quintal JM,
Growth regulation, imprinted genes and chromosome
Dallapiccola B, Fischer G, Frieden IJ, Garzon M, Harper J,
11p15.5. Pediatric Research 2007: 61(5 Pt 2):
Johnson-Patel J, Labreze C, Martorell L, Paltiel HJ, Pohl
pp 43R-47R.
143(23): pp 2924-2930.
Van der Knaap MS, Linnankivi T, Paetau A, Feigenbaum A,
Wakusawa K, Haginoya K, Kohler W, Henneke M,
Dinopoulos A, Grattan-Smith P, Brockmann K,
A, Prendiville J, Rohrbach M, Clarke JTR: Treatment of
lysosomal storage disorders: progress with enzyme
Somech R, Somers GR, Chitayat D, Grunebaum E,
Schiffmann R, Blaser S: Hypomyelination with atrophy
replacement therapy. Drugs 2007: 67: pp 2697-2716.
Atkinson A, Kolomietz E, Roifman CM: Fatal lung
of the basal ganglia and cerebellum. Follow-up and
fibrosis associated with immunodeficiency and
pathology. Neurology 2007: 69: pp 166-171.
Quere I, Siegel DH, Valente EM, Van Hagen A, Van
gonadal dysgenesis in 46XX sisters – a new syndrome.
Hest L, Vaux KK, Vicente A, Weibel L, Chitayat D,
American Journal of Medical Genetics. Part A 2008:
Verbruggen KT, Sijens PE, Schulze A, Lunsing RJ,
Vikkula M: Parkes Weber syndrome, vein of Galen
146(1): pp 8-14.
Jakobs C, Salomons GS, van Spronsen FJ. Successful
aneurysmal malformation, and other fast-flow vascular
treatment of a guanidinoacetate methyltransferase
anomalies are caused by RASA1 mutations. Human
deficient patient: findings with relevance to treatment
Mutations 2008: 29(7): pp 959-965.
strategy and pathophysiology. Molecular Genetics
and Metabolism 2007: 91(3): pp 294-296.
30 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Watts P, Kumar N, Ganesh A, Sastry P, Pilz D, Levin AV,
Yoon G, Westmacott R, MacMillan L, Quercia N,
Hughes S, Weksberg R, Moldovan L: Use of
Chitayat D: Chorioretinal dysplasia, hydranencephaly,
Koutsou P, Georghiou A, Christodoulou K, Banwell B:
quantitative PCR for the detection of genomic
and intracranial calcifications: pseudo-TORCH or a
Complete deletion of the aprataxin gene: ataxia with
microdeletions or microduplications. In: PCR
new syndrome? Eye 2008: 22(5): pp 730-733.
oculomotor apraxia type 1 with severe phenotype and
Methods Express (Hughes S, Moody A, eds.).
cognitive deficit. Journal of Neurology, Neurosurgery
Scion Publishing Ltd., United Kingdom, 2007.
Weksberg R, Shuman C, Wilkins-Haug L, Mann M,
and Psychiatry 2008: 79(2): pp 234-236.
Stewart D, Croughan M, Rakowsky C, Leader A, Hall J,
Mendoza-Londono R, Ardelean D, Goobie S:
Friedman JM, Simpson JL, Holmes L, Infante-Rivard C:
Zampino G, Pantaleoni F, Carta C, Cobellis G, Vasta I,
Genetics: In: The Hospital for Sick Children
Workshop report: evaluation of genetic and epigenetic
Neri C, Pogna E, De Feo E, Delogu A, Sarkozy A, Atzeri F,
Handbook of Paediatrics. Elsevier, Canada, 2007.
risks associated with assisted reproductive
Selicorni A, Rauen K, Cytrynbaum C, Weksberg R,
technologies and infertility. Fertility and Sterility 2007:
Dallapiccola B, Ballabio A, Gelb B, Neri G, Tartaglia M:
Schulze A, Battini R: Pre-symptomatic treatment
88(1): pp 27-31.
Diversity, parental germline origin, and phenotypic
of Creatine biosynthesis defects. In: Creatine and
spectrum of de nova HRAS missense changes in Costello
creatine Kinase in Health and Disease (Salomons
syndrome. Human Mutation 2007: 28(3): pp 265-272.
GS, Wyss M, eds.). Springer, Dordrecht, 2007.
Werner T, Treiss I, Kohlmueller D, Mehlem P, Teich M,
Longin E, Gerstner T, Koenig SA, Schulze A: Effects of
valproate on acylcarnitines in children with epilepsy
BOOKS AND BOOK CHAPTERS
Wyss M, Braissant O, Pischel I, Salomons GS,
using ESI-MS/MS. Epilepsia 2007: 48(1): pp 72-76.
Chitayat D: The clinical approach to the newborn with
Schulze A, Stockler S, Wallimann T: Creatine and
multiple abnormalities. In: Residents Handbook of
creatine kinase in health and disease - a bright future
Yoon G, Rosenberg J, Blaser S, Rauen KA:
Neonatology, 3rd Edition (Kirpalani H, Moore A,
ahead? In: Creatine and Creatine Kinase in Health
Neurological complications of the cardio-facio-
Perlman M, eds.). B.C. Decker Inc., Hamilton, Ontario,
and Disease (Salomons GS, Wyss M, eds.). Springer,
cutaneous syndrome (CFC). Developmental Medicine
Canada, 2007.
Dordrecht, 2007.
and Child Neurology 2007: 49(12): pp 894–899.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 31
FUNDING
Canadian Molecular Cytogenetics Platform.
Gene expression of neuronal progenitors in a
Analysis of imprinting control in a tumour predisposing
Friedman JM, Chitayat D, Meyn S, Weksberg R.
1q22-linked familial subtype of schizophrenia.
region on human chromosome 11p15. Weksberg R,
Canadian Foundation for Innovation ($4,512,925
McCurdy R, Weksberg R. Canadian Psychiatric
Squire J. Canadian Institutes of Health Research
2005-2010)
Research Foundation (CPRF) ($80,000 2005-2007)
Collaborative Graduate Training Program in Molecular
Genome-wide DNA methylation profiling in autism.
Autism: Searching for epigenetics errors. Weksberg R.
Medicine (training grant) Canadian Institutes of
Weksberg R, Roberts W, Scherer S. Canadian
SickKids Foundation New Ideas Grant ($50,000
Health Research ($300,000 2002-2008)
Institutes of Health Research ($649,518 2008-2011)
Dynamics of human double-strand break repair.
Hunter Outcome Survey. Clarke, J. Shire Human
($359,565 2004-2007)
2007-2008)
A retrospective natural history study of ASM deficiency
Meyn S. Canadian Institutes of Health Research
Genetic Therapies ($560 per patient ID entry
(Niemann-Pick Disease Types A and B). Clarke J.
($123,000 2004-2008)
2007-2009)
Genzyme Corporation ($26,995 2005-2008)
Canadian Fabry Disease Initiative (combined adult
Fabry Outcome Survey. Clarke J. Shire Human Genetic
Iduronate-2-sulfatase enzyme replacement therapy in
Therapies ($110,000 2007-2009)
mucopolysaccharidosis II (MPS II). Clarke J. Shire
Human Genetics Therapies ($111,497 2005-2008)
and paediatric patients). Sirrs S, Casey R, Clarke J,
Bichet D, West M. Canadian federal and provincial
Formation and evaluation of a comprehensive
governments, private stakeholders ($2,967,450
computer-based teaching module concerning the
2006-2009)
Integrative genomics for health research. Scherer S,
recognition, diagnosis, and treatment of MPS II (Hunter
Weksberg R. Canadian Foundation for Innovation
disease). Clarke J, Al-Jasmi F, Moldovan L. Shire
($3,600,262 2004-2008)
Human Genetics Therapies ($149,491 2007- 2008)
32 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Investigation of intrauterine growth restriction by gene
Pregnancy and development outcomes. Weksberg R,
expression and DNA methylation profiling. Weksberg R,
Goobie S, Kim L, Roberts W, Croughan M. The
Chitayat D, Kingdom J, Keating S. Canadian Institutes
Physicians Services Incorporated Foundation
of Health Research ($383,883 2008-2011)
($20,000 2007-2008)
MPS I and other lysosomal diseases registry. Clarke J.
Rare Diseases Clinical Research Centre for urea
Genzyme Corporation ($224,901 2006-2009)
cycle disorders. Clarke J, Feigenbaum A. Canadian
Institutes of Health Research ($25,000 2006-2008)
Potential predictor of schizophrenia in a genetic
high-risk sample: Ontario project. Chow E, Bassett A,
Selective killing of ALT-dependent malignant cells by
Weksberg R, Zipursky R, Mikulis D. Ontario Mental
inhibition of the Fanconi anaemia pathway: a pilot
Health Foundation, Bill Jefferies Schizophrenia
study. Meyn S. The Hospital for Sick Children
Endowment Fund ($148,188 2002-2008)
Research Institute Seed Grant ($50,000 2008-2009)
Urea Cycle Diseases Consortium: longitudinal study of
urea cycle disorders. Feigenbaum A. Mendel
Tuchman/Mark Batshaw USA ($7,000 2007-2008)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 33
Dr. Gideon Koren
Dr. Irena Nulman
DIVISION HEAD
Dr. Shinya Ito
Dr. Irena Nulman
Dr. Margaret Thompson
SCIENTIFIC STAFF
Dr. Patricia Harper
FULL-TIME
Dr. Gideon Koren
Dr. Christine Newman
PART-TIME
Dr. David Juurlink
CROSS-APPOINTEES/
CLINICAL
Dr. Christopher Parshuram
Dr. Denis Scolnik
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Neil Shear
Ran Goldman
Sheila Jacobson
Sylvain Baruchel
Marco Sivilotti
Prashant Joshi
CROSS-APPOINTEES/
SCIENTIFIC
Dr. Lidia Derewlany
Dr. Tom Einarson
Dr. Anna Taddio
Dr. Bonnie Stevens
CLINICAL FELLOWS
Dr. Nobuko Taguchi
Dr. Radinka Boskovic
Dr. Yaron Finkelstein
Dr. Tali Finkelstein
Dr. Facundo Garcia Bournissen
Division of Clinical Pharmacology & Toxicology
OVERVIEW
The division is one of the two major training sites of
PUBLICATIONS
The Division of Clinical Pharmacology & Toxicology
the Royal College-accredited Clinical Pharmacology
Avner M, Finkelstein Y, Hackam D, Koren G:
focusses on a wide range of drug-related issues in
Residency Program of the University of Toronto. Our
Establishing causality in pediatric adverse drug
paediatrics. The division is one of the largest and one
medical residency training program spearheaded the
reactions: use of the Naranjo probability scale.
of the most active paediatric pharmacology programs
recent change of the specialty residency training
Paediatric Drugs 2007: 9: pp 267-270.
internationally. Our major clinical activities include
structure to add Emergency Medicine to the existing
a consultation service, the Motherisk program, the
four entry disciplines, which include Paediatrics. This
Bar-Oz B, Einarson T, Einarson A, Boskovic R,
Ontario Regional Poison Information Centre, and the
change enables us to train residents with emergency
O’Brien L, Malm H, Berard A, Koren G: Paroxetine
DART (Drug Allergy, Reactions and Toxicity) clinic in
medicine background in the clinical toxicology stream
and congenital malformation: meta-analysis and
collaboration with the Division of Immunology/Allergy
of our education program.
consideration of potential confounding factors.
which provides specialized outpatient follow up and
Clinical Therapeutics 2007: 29: pp 918-926.
management for those with various drug/toxin-related
Our research programs focus on drug metabolizing
problems. The two toxicology information centres
enzymes and their regulation, drug transporters,
Bennett HA, Einarson A, Taddio A, Koren G, Einarson TR:
receive annually about 35,000 (Motherisk) and
placental and mammary gland drug transport and
Depression during pregnancy: overview of clinical
75,000 (Poison Information Centre) inquiries which
metabolism, and reproductive toxicology and
factors. Clinical Drug Investigation 2007: 24: pp 157-179.
have reached the limit of the response capacity of
teratology, including fetal alcohol syndrome research.
the systems. The Motherisk program, directed by
The breadth and depth of these research programs
Berard A, Azoulay L, Koren G, Blais L, Perreault S,
Dr. Gideon Koren, continues disseminating new
are shown in the publication and funding records.
Oraichi D: Isotretinoin, pregnancies, abortions and
breastfeeding babies. The Ontario Regional Poison
HONOURS AND AWARDS
Journal of Clinical Pharmacology 2007: 63: pp 196-205.
Information Centre led by Dr. Margaret Thompson
Koren G: Spirit of the Community Humanitarian Award,
has now become a hub for medical toxicology training,
Toronto, 2007.
Bozzo P, Koren G, Nava-Ocampo AA, Einarson A: The
internationally. The Palliative and Bereavement Care
Koren G: Canadian Society for Clinical Pharmacology,
a comparison between depressed women treated with
Service directed by Dr. Christine Newman has recently
Education Award, 2007.
antidepressants and non-depressed women. Clinical
knowledge in the field of drug safety for fetus and
birth defects: a population-based perspective. British
attracting many residents and fellows nationally and
incidence of nausea and vomiting of pregnancy (NVP):
become a part of the division and provides expertise
specifically on drug therapy for terminally ill patients.
and Investigative Medicine 2007: 29: pp 347-350.
Koren G: Schwartz-Riesman Visiting Professorship,
Tel Aviv University, 2007.
CLINICAL FELLOWS
Dr. Parvaneh Yazdanibrojeni
Dr. Miho Inoue
Dr. Toshihiro Tanaka
Dr. Saskia de-Wildt
Dr. Dan Rhodes
Dr.
Dr.
Dr.
Dr.
Arthur Staroselsky
Alla Osadchy
Aleksey Kazmin
Chagit Klieger-Grossman
RESEARCH FELLOWS
Dr. Alejandro A. Nava-Ocampo
Dr. Shin-ichiro Takahashi
Dr. Nada Djokanovic
Dr. Naziha Mahmoud
RESEARCH ASSOCIATE
Katarina Aleksa
RESIDENT
Dr. Lisa Thurgur
ADMINISTRATIVE STAFF
Niki Balamatsis
Hila Halshtok
Leah Moscato
Sarah Bondy
Donna Tedesco
Chambers C, Koren G, Tutuncu ZN, Johnson D,
de Wildt SN, Koren G: Authors’ reply. Paediatric
Einarson TR, Koren G, Einarson A: Problems with
Jones KL: Are new agents used to treat rheumatoid
Anaesthesia 2008: 18: pp 273-274.
maternal antidepressant treatment and neonatal
outcomes study. Archives of General Psychiatry
arthritis safe to take during pregnancy? Organization
of Teratology Information Specialists (OTIS) study.
Dubnov-Raz G, Finkelstein Y, Koren G: Omega-3 fatty
Canadian Family Physician 2007: 53: pp 409-412.
acid supplementation during pregnancy: For mother,
baby, or neither? Canadian Family Physician 2007: 53:
Chen N, Aleksa K, Woodland C, Rieder M, Koren G:
pp 817-818.
2007: 64: p 866.
Einarson TR, Navioz Y, Maltepe C, Einarson A, Koren G:
Existence and severity of nausea and vomiting in
pregnancy (NVP) with different partners. Journal of
N-Acetylcysteine prevents ifosfamide-induced
Obstetrics and Gynaecology 2007: 27: pp 360-362.
nephrotoxicity in rats. British Journal of
Dugoua JJ, Perri D, Seely D, Mills E, Koren G:
Pharmacology 2008: 153: pp 1364-1372.
Safety and efficacy of blue cohosh (Caulophyllum
thalictroides) during pregnancy and lactation.
Etwel FA, Rieder MJ, Bend JR, Koren G:
Chen N, Aleksa K, Woodland C, Rieder M,
Canadian Journal of Clinical Pharmacology 2008:
A surveillance method for the early identification
Koren G: Prevention of ifosfamide nephrotoxicity
15: pp e66-e73.
of idiosyncratic adverse drug reactions. Drug Safety
2008: 31: pp 169-180.
by N-acetylcysteine: Clinical pharmacokinetic
considerations. Canadian Journal of Clinical
Pharmacology 2007: 14: pp 246-250.
Chen N, Aleksa K, Woodland C, Rieder M, Koren G:
Dugoua JJ, Seely D, Perri D, Koren G, Mills E:
Safety and efficacy of chastetree (vitex agnus-castus)
Feig DS, Briggs GG, Koren G: Oral antidiabetic agents
during pregnancy and lactation. Canadian Journal
in pregnancy and lactation: a paradigm shift? Annals
of Clinical Pharmacology 2008: 15: pp e74-e79.
of Pharmacotherapy 2007: 41: pp 1174-1180.
The effect of N-acetylcysteine on ifosfamide-induced
nephrotoxicity: In vitro studies in renal tubular cells.
Dugoua JJ, Seely D, Perri D, Mills E, Koren G: Safety
Finkelstein Y, Rezvani M, Garcia-Bournissen F,
Translucent Research 2007: 150: pp 51-57.
and efficacy of cranberry (vaccinium macrocarpon)
Nurmohamed L, Koren G: Inactive pharmaceutical
during pregnancy and lactation. Canadian Journal
ingredients: implications for pregnancy. Canadian
De Rosa MF, Ackerley C, Clarke D, Wang B, Ito S,
of Clinical Pharmacology 2008: 15: pp e80-e86.
Journal of Clinical Pharmacology 2007: 14: pp e17-e28.
Lingwood C. Inhibition of multidrug resistance 1 (MDR1)
by adamantylGb3, a globotraosylceramide analog.
Einarson A, Koren G: Prescrire des antidГ©presseurs
Journal of Biology Chemistry 2008: 283: pp 4501-4511.
aux femmes enceintes: que doivent faire les mГ©decins
de famille? Canadian Family Physician 2007: 53:
pp 1423-1425.
36 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Goh YI, Bollano E, Einarson TR, Koren G: Prenatal
Finkelstein Y, Wahl MS, Bentur Y, Schechter T,
Garcia-Bournissen F, Finkelstein Y, Rezvani M, Koren G:
Garty BZ, Erickson TB, Chodick G, Cahana A,
Exposure to alcohol-containing medications during
multivitamin supplementation and rates of pediatric
Mounstephen WJ, Koren G, Aks SE: Universal versus
pregnancy. Canadian Family Physician 2007: 52:
cancers: a meta-analysis. Clinical Pharmacology
selective iron supplementation for infants and the
pp 1067-1068.
and Therapeutics 2007: 81: pp 685-691.
a comparative study of two populations. Annals of
Garcia-Bournissen F, Rokach B, Karaskov T, Koren G:
Goh YI, Koren G: Folic acid in pregnancy and fetal
Pharmacotherapy 2007: 41: pp 414-419.
Cocaine detection in maternal and neonatal hair:
outcomes. Journal of Obstetrics and Gynaecology
implications to fetal toxicology. Therapeutic Drug
2008: 28: pp 3-13.
risk of unintentional poisoning in young children:
Florescu A, Ferrence R, Einarson TR, Selby P, Kramer M,
Monitoring 2007: 29: pp 71-76.
Goldman RD, Ong M, Wolpi J, Doyle J, Parshuram C,
Woodruff S, Grossman L, Rankin A, Jacqz-Aigrain E,
Koren G: Reference values for hair cotinine as a
Garcia-Bournissen F, Shrim A, Koren G: Exposure
Koren G: Pharmacological risk factors for
biomarker of active and passive smoking in women
to sibutramine during pregnancy. Canadian Family
amphotericin B nephrotoxicity in children. Journal
of reproductive age, pregnant women, children, and
Physician 2007: 53: pp 229-230.
of Clinical Pharmacology 2007: 47: pp 1049-1054.
Gearing RE, Selkirk EK, Koren G, Leslie M, Motz M,
Goldstein LH, Dolinsky G, Greenberg R, Schaefer C,
Zelazo LB, McNeill T, Lozier FA: Perspectives of
Cohen-Kerem R, Diav-Citrin O, Malm H, Reuvers-
neonates: systematic review and meta-analysis.
Therapeutic Drug Monitoring 2007: 29: pp 437-446.
Forman R, Gill S, Moretti M, Tulandi T, Koren G,
mothers with substance use problems on father
Lodewijks ME, Rost van Tonningen-van Driel MM,
Casper R: Fetal safety of letrozole and clomiphene
involvement. Canadian Journal of Clinical
Arnon J, Ornoy A, Clementi M, DiGianantonio E, Koren G,
citrate for ovulation induction. Journal of Obstetrics
Pharmacology 2008: 15: pp e99-e107.
Braunstein R, Berkovitch M: Pregnancy outcome
of women exposed to azathioprine during pregnancy.
and Gynaecology Canada 2007: 29: pp 668-671.
Gedeon C, Anger G, Piquette-Miller M, Koren G:
Birth defects research, Part A. Clinical and Molecular
Garcia-Bournissen F, Asrar F, Verjee Z, Karaskov T,
Breast cancer resistance protein: mediating the
Teratology 2007: 79: pp 696-701.
Koren G: Contamination of hair with 3,4-methylene
trans-placental transfer of glyburide across
dioxymethamphetamine (ecstasy) in two young girls
the human placenta. Placenta 2008: 29: pp 39-43.
from a “meth lab.” Clinical Pediatrics (Philadelphia)
2008: 47: pp 186-188.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 37
Hancock RL, Koren G, Einarson A, Ungar WJ: The
Kirkwood A, Harris C, Timar N, Koren G: Is gentamicin
Koren G, Maltepe C: Preventing recurrence of severe
effectiveness of Teratology Information Services (TIS).
ototoxic to the fetus? Journal of Obstetrics and
morning sickness. Canadian Family Physician 2007:
Reproductive Toxicology 2007: 23: pp 125-132.
Gynaecology Canada 2007: 29: pp 140-145.
52: pp 1545-1546.
Huber AM, Tomlinson GA, Koren G, Feldman BM:
Koren G, Chen N, Aleksa K: Drug-induced
Koren G, Nulman I: Critical appraisal rounds: a new
Amitriptyline to relieve pain in juvenile idiopathic
nephrotoxciity in children: pharmacologically based
training model for clinical pharmacologists. Canadian
arthritis: a pilot study using Bayesian meta-analysis
prevention of long-term impairment. Paediatric
Journal of Clinical Pharmacology 2007: 14: pp e81-85.
of multiple N-of-1 clinical trials. Journal of
Drugs 2007: 9: pp 139-142.
Koren G, Pairaideau N: Compliance with prenatal
Rheumatology 2007: 34: pp 1125-1132.
Koren G, Kramer M, Mattison D: The Summer
vitamins. Patients with morning sickness sometimes
Humphreys C, Garcia-Bournissen F, Ito S, Koren G:
Institutes in Maternal-Fetal Pharmacology: building
find it difficult. Canadian Family Physician 2007: 52:
Expsoure to attention deficit hyperactivity disorder
critical mass in a neglected area. Journal of Obstetrics
pp 1392-1393.
medications during pregnancy. Canadian Family
and Gynaecology Canada 2007: 29: pp 544-545.
Koren G: Changes in drug handling during pregnancy:
Physician 2007: 53: pp 1153-1155.
Koren G, MacLeod S, Davis D: Drugs in pregnancy:
what it might mean for your patients. Canadian Family
Physician 2007: 52: pp 1214-1215.
Kalra S, Einarson A, Karaskov T, Van Uum S, Koren G:
acknowledging challenges–finding solutions. Canadian
The relationship between stress and hair cortisol in
Journal of Clinical Pharmacology 2007:
healthy pregnant women. Clinical Investigative
14: pp e2-e4.
Koren G: Complementary and alternative medicine
for children–time to enter the evidence-based era.
Medicine 2007: 30: pp 103-107.
Canadian Journal of Clinical Pharmacology 2007:
14: p e103.
Liu GX, Zhou J, Koren G: Single-channel properties
Dr. Shinya Ito and team
of 1 (K, slow1) and I (K,slow2) in mouse ventricular
myocytes. Pflugers Archives 2008: 456(3): pp 541-547.
38 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Kosuge K, Chuang A, Uematsu S, Tan KP, Ko BCB,
O’Brien L, Schachtschneider AM, Koren G, Walker JH,
Sauve B, Koren G, Walsh G, Tokmakejian S,
Ohashi K, Ito S: Discovery of osmo-sensitive
Einarson A: Longitudinal study of depression, anxiety,
Van Uum SH: Measurement of cortisol in human
transcriptional regulation of human cytochrome P450
irritability, and stress in pregnancy following evidence-
hair as a biomarker of systemic exposure. Clinical
3As by the tonicity-responsive enhancer binding
based counseling on the use of antidepressants.
Investigative Medicine 2007: 30: pp 183-191.
protein (nuclear factor of activated T cells 5).
Journal of Psychiatry Practice 2007: 13: pp 33-39.
Schechter T, Finkelstein Y, Doyle J, Verjee Z, Moretti M,
Molecular Pharmacology 2007: 72: pp 826-837.
Parshuram CS, To T, Seto W, Trope A, Koren G,
Koren G, Dupuis LL: Pharmacokinetic disposition and
Lau AC, Duong TT, Ito S, Yeung RSM: Matrix
Laupacis A: Systematic evaluation of errors occurring
clinical outcomes in infants and children receiving
metalloproteinase-9 activity leads to coronary
during the preparation of intravenous medication.
intravenous busulfan for allogeneic hematopoietic
aneurysms in an animal model of Kawasaki disease.
Canadian Medical Association Journal 2008: 178: pp 42-48.
stem cell transplantation. Biology Blood Marrow
Transplant 2007: 13: pp 307-314.
Arthritis and Rheumatism 2008: 58: pp 854-863.
Pereg D, Koren G, Lishner M: The treatment of
Madadi P, Koren G, Cairns J, Chitayat D, Gaedigk A,
Hodgkin’s and non-Hodgkin’s lymphoma in pregnancy.
Seely D, Dugoua JJ, Perri D, Mills E, Koren G: Safety
Leeder JS, Teitelbaum R, Karaskov T, Aleksa K: Safety
Haematologica 2007: 92: pp 1230-1237.
and efficacy of panax ginseng during pregnancy and
lactation. Canadian Journal of Clinical Pharmacology
of codeine during breastfeeding: fatal morphine
poisoning in the breastfed neonate of a mother
Piwko C, Ungar WJ, Einarson TR, Wolpin J, Koren G:
prescribed codeine. Canadian Family Physician 2007:
The weekly cost of nausea and vomiting of pregnancy
53: pp 33-35.
for women calling the Toronto Motherisk Program.
2008: 15: pp e87-e94.
Shor S, Koren G, Nulman I: Teratogenicity of
Current Medical Research Opinion 2007: 23: pp 833-840.
lamotrigine. Canadian Family Physician 2007:
53: pp 1007-1009.
Moretti ME, Verjee Z, Ito S, Koren G: Breastfeeding
during maternal use of azathioprine. Annals of
Ray JG, Vermeulen MJ, Koren G: Taking ACE inhibitors
Pharmacotherapy 2007: 40: pp 2269-2272.
during early pregnancy: is it safe? Canadian Family
Shrim A, Garcia-Bournissen F, Koren G:
Pharmaceutical agents and pregnancy in urology
Physician 2007: 53: pp 1439-1440.
practice. Urology Clinical North America 2007:
Nava-Ocampo AA, Koren G: Human teratogens
and evidence-based teratogen risk counseling:
Rezvani M, Finkelstein Y, Verjee Z, Railton C, Koren G:
the Motherisk approach. Clinical Obstetrics and
Generalized seizures following topical lidocaine
Gynaecology 2007: 50: pp 123-131.
administration during circumcision: establishing
34: pp 27-33.
causation. Paediatric Drugs 2007: 9: pp 125-127.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 39
Shrim A, Garcia-Bournissen F, Maxwell C, Farine D,
Sung L, Tomlinson GA, Greenberg ML, Koren G, Judd P,
Zhu M, Gach AA, Liu G, Xu X, Lim CC, Zhang J, Mao L,
Koren G: Favorable pregnancy outcome following
Ota S, Feldman BM: Serial controlled N-of-1 trials of
Chuprun JK, Koch WJ, Liao R, Koren G, Blaxall BC,
Trastuzumab (Herceptin) use during pregnancy–case
topical vitamin E as prophylaxis for chemotherapy-
Mende U: Enhanced calcium cycling and contractile
report and updated literature review. Reproductive
induced oral mucositis in paediatric patients.
function in transgenic hearts expressing constitutively
Toxicology 2007: 23: pp 611-613.
European Journal of Cancer 2007: 43: pp 1269-1275.
active G (alpha) protein. American Journal of
Physiology–Heart and Circulatory Physiology 2008:
Shrim A, Garcia-Bournissen F, Maxwell C, Farine D,
Sutander M, Garcia-Bournissen F, Koren G:
Koren G: Trastuzumab treatment for breast cancer
Hypothyroidism in pregnancy. Journal of Obstetrics
during pregnancy. Canadian Family Physician 2008:
and Gynaecology Canada 2007: 29: pp 354-356.
54: pp 31-32.
294(3): pp H1335-H1347.
BOOKS AND BOOK CHAPTERS
Addis A, Koren G: Safety of fluoxetine during the first
Taguchi N, Mian M, Shouldice M, Karaskov T, Gareri J,
trimester of pregnancy: a meta-analytical review of
Sivojelezova A, Koren G, Einarson A: Glucosamine use
Nulman I, Verjee ZH, Koren G: Chronic cocaine
epidemiological studies. In: The Evidence-Based A-to-Z
in pregnancy: an evaluation of pregnancy outcome.
exposure in a toddler revealed by hair test. Clinical
Clinician’s Pocket Guide, Part II, Section 4. McGraw
Journal of Women’s Health 2007: 16: pp 345-348.
Pediatrics 2007: 46: pp 272-275.
Hill, New York, 2007.
Stade B, Ungar WJ, Stevens B, Beyen J, Koren G:
Tan KP, Yang M, Ito S: Activation of Nrf2 by toxic
Addis A, Moretti EM, Syed AF, Einarson RT, Koren G:
Cost of fetal alcohol syndrome disorder in Canada.
bile acids provokes adaptive defense responses to
Fetal effects of cocaine: an updated meta-analysis.
Canadian Family Physician 2007: 53: pp 1303-1304.
enhance cell survival at the emergence of oxidative
In: The Evidence-Based, A-to-Z Clinician’s Pocket
stress. Molecular Pharmacology 2007: 72: pp 1380-1390.
Guide, Part II, Section 3. McGraw Hill, New York, 2007.
American Gastroenterological Association Institute
Yamada J, Stevens B, de Silva N, Gibbins S, Beyene J,
Bar-Oz B, Hackman R, Einarson RT, Koren G:
Staroselsky A, Garcia-Bournissen F, Koren G:
medical position statement on the use of
Taddio A, Newman C, Koren G: Hair cortisol as a
Pregnancy outcome after cyclosporine therapy during
gastrointestinal medication in pregnancy.
potential biologic marker of chronic stress in hospitalized
pregnancy: a meta-analysis. In: The Evidence-Based,
Gastroenterology 2007: 132: pp 824-825.
neonates. Neonatology 2007: 92: pp 42-49.
A-to-Z Clinician’s Pocket Guide, Part II, Section 4.
McGraw Hill, New York, 2007.
Staroselsky A, Nava-Ocampo AA, Vohra S,
Koren G: Hemorrhoids in pregnancy. Canadian
Family Physician 2008: 54: pp 189-190.
40 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Bar-Oz B, Moretti EM, Mareels G, Van Tittelboom T,
Bentur Y, Koren G: The common occupational
Dolovich RL, Addis A, Vaillancourt JMR, Power JDB,
Koren G: Reporting bias in retrospective
exposures encountered by pregnant women. In:
Koren G, Einarson RT: Benzodiazepine use in
ascertainment of drug-induced embryopathy. In: The
The Evidence-Based, A-to-Z Clinician’s Pocket Guide,
pregnancy and major malformations or oral cleft:
Evidence-Based, A-to-Z Clinician’s Pocket Guide, Part
Part I. McGraw Hill, New York, 2007.
meta-analysis of cohort and case-control studies. In:
The Evidence-Based, A-to-Z Clinician’s Pocket Guide,
II, Section 1. McGraw Hill, New York, 2007.
Bonari L, Pinto N, Ahn E, Einarson A, Steiner M, Koren G:
Part II, Section 4. McGraw Hill, New York, 2007.
Ben David S, Einarson RT, Ben David Y, Nulman I,
Perinatal risks of untreated depression during
Pastuszak A, Koren G: The safety of nitrofurantoin
pregnancy. In: The Evidence-Based, A-to-Z Clinician’s
Einarson RT, Koren G, Mattice D, Schechter-Tsafriri C:
during the first trimester of pregnancy: a meta-
Pocket Guide, Part I. McGraw Hill, New York, 2007.
Maternal spermicide use and adverse reproductive
Pocket Guide, Part II, Section 4. McGraw Hill, New
Burtin P, Taddio A, Ariburnu O, Einarson RT, Koren G:
A-to-Z Clinician’s Pocket Guide, Part II, Section 4.
York, 2007.
Safety of metronidazole in pregnancy: a meta-analysis.
McGraw Hill, New York, 2007.
Bennett AH, Einarson A, Taddio A, Koren G, Einarson
Guide, Part II, Section 4. McGraw Hill, New York, 2007.
outcome: A meta-analysis. In: The Evidence-Based,
analysis. In: The Evidence-Based, A-to-Z Clinician’s
In: The Evidence-Based, A-to-Z Clinician’s Pocket
Einarson RT, Leeder JS, Koren G: A method for
meta-analysis of epidemiological studies. In: The
RT: Prevalence of depression during pregnancy:
systematic review. In: The Evidence-Based, A-to-Z
Cohen-Kerem R, Railton C, Oren D, Lishner M,
Evidence-Based, A-to-Z Clinician’s Pocket Guide,
Clinician’s Pocket Guide, Part II, Section 2. McGraw
Koren G: Pregnancy outcome following non-obstetric
Part II, Section 1. McGraw Hill, New York, 2007.
Hill, New York, 2007.
surgical intervention. In: The Evidence-Based,
Bentur Y, Koren G: Occupational exposures known
A-to-Z Clinician’s Pocket Guide, Part II, Section 2.
Fernandes O, Sabharwal M, Smiley T, Pastuszak A,
McGraw Hill, New York, 2007.
Koren G, Einarson T: Moderate to heavy caffeine
consumption during pregnancy and relationship to
to be human reproductive poisons. In: The EvidenceBased, A-to-Z Clinician’s Pocket Guide, Part I.
Diav-Citrin O, Koren G: Direct drug toxicity to the fetus.
spontaneous abortion and abnormal fetal growth:
McGraw Hill, New York, 2007.
In: The Evidence-Based, A-to-Z Clinician’s Pocket
a meta-analysis. In: The Evidence-Based, A-to-Z
Guide, Part I. McGraw Hill, New York, 2007.
Clinician’s Pocket Guide, Part II, Section 3.
McGraw Hill, New York, 2007.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 41
Fried S, Kozer E, Nulman I, Einarson RT, Koren G:
Gilbert C, Valois M, Koren G: Pregnancy outcome after
Hard LM, Einarson RT, Koren G: The role of
Malformation rates in children of women with
first-trimester exposure to metformin: a meta-analysis.
acetaldehyde in pregnancy outcome after prenatal
untreated epilepsy: a meta-analysis. In: The
In: The Evidence-Based, A-to-Z Clinician’s Pocket
alcohol exposure. In: The Evidence-Based, A-to-Z
Evidence-Based, A-to-Z Clinician’s Pocket Guide,
Guide, Part II, Section 4. McGraw Hill, New York, 2007.
Clinician’s Pocket Guide, Part II, Section 3. McGraw
Hill, New York, 2007.
Part II, Section 2. McGraw Hill, New York, 2007.
Goh YI, Bollano E, Einarson RT, Koren G: Prenatal
Gareri NJ, Klein J, Koren G: Determination of prenatal
multivitamin supplementation and rates of congenital
Hemels EHM, Einarson A, Koren G, Lanctot LK,
exposures: In: The Evidence-Based, A-to-Z Clinician’s
anomalies: a meta-analysis. In: The Evidence-Based,
Einarson RT: Antidepressant use during pregnancy
Pocket Guide, Part I. McGraw Hill, New York, 2007.
A-to-Z Clinician’s Pocket Guide, Part II, Section 4.
and the rates of spontaneous abortions: a meta-
McGraw Hill, New York, 2007.
analysis. In: The Evidence-Based, A-to-Z Clinician’s
disposition in the maternal-fetal unit. In: The Evidence-
Goh YI, Koren G: Folic acid and congenital birth defects:
York, 2007.
Based, A-to-Z Clinician’s Pocket Guide, Part II. McGraw
a review. In: The Evidence-Based, A-to-Z Clinician’s
Hill, New York, 2007.
Pocket Guide, Part I. McGraw Hill, New York, 2007.
Pocket Guide, Part II, Section 4. McGraw Hill, New
Gedeon C, Koren G: Gestational changes in drug
Koren G, Nava-Ocampo AA, Moretti EM, Sussman R,
Nulman I: Major malformations with valproic acid. In:
Gilbert C, Mazzotta P, Loebstein R, Koren G: Fetal
Gutzin J, Kozer E, Magee AL, Feig SD, Koren G:
The Evidence-Based, A-to-Z Clinician’s Pocket Guide,
safety of drugs used in the treatment of allergic
The safety of oral hypoglycemic agents in the first
Part II, Section 4. McGraw Hill, New York, 2007.
rhinitis: a critical review. In: The Evidence-Based,
trimester of pregnancy: a meta-analysis. In: The
A-to-Z Clinician’s Pocket Guide, Part II, Section 4.
Evidence-Based, A-to-Z Clinician’s Pocket Guide,
Koren G: Bias against the null hypothesis in
McGraw Hill, New York, 2007.
Part II, Section 4. McGraw Hill, New York, 2007.
maternal-fetal pharmacology and toxicology. In:
The Evidence-Based, A-to-Z Clinician’s Pocket Guide,
Part II, Section 1. McGraw Hill, New York, 2007.
42 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
McMartin IK, Chu M, Kopecky E, Einarson RT, Koren G:
Koren G: Drugs in pregnancy: acknowledging
Magee AL, Elran E, Bull BS, Logan A, Koren G: Risks
challenges–finding solutions. In: The Evidence-Based,
and benefits of ОІ-receptor blockers for pregnancy
Pregnancy outcome following maternal organic solvent
A-to-Z Clinician’s Pocket Guide, Part I. McGraw Hill,
hypertension: overview of the randomized trials. In:
exposure: a meta-analysis of epidemiologic studies.
New York, 2007.
The Evidence-Based, A-to-Z Clinician’s Pocket Guide,
In: The Evidence-Based, A-to-Z Clinician’s Pocket
Part II, Section 4. McGraw Hill, New York, 2007.
Guide, Part II, Section 3. McGraw Hill, New York, 2007.
In: The Evidence-Based, A-to-Z Clinician’s Pocket
Magee AL, Mazzotta P, Koren G: Evidence-based view
Moretti EM, Bar-Oz B, Fried S, Koren G: Maternal
Guide, Part I. McGraw Hill, New York, 2007.
of safety and effectiveness of pharmacologic therapy
hyperthermia and the risk for neural tube defects in
for nausea and vomiting during pregnancy (NVP). In:
offspring: systematic review and meta-analysis. In:
Koren G: Risk of varicella infection during late pregnancy.
The Evidence-Based, A-to-Z Clinician’s Pocket Guide,
The Evidence-Based, A-to-Z Clinician’s Pocket Guide,
In: The Evidence-Based, A-to-Z Clinician’s Pocket
Part II, Section 4. McGraw Hill, New York, 2007.
Part II, Section 2. McGraw Hill, New York, 2007.
Koren G: Medication in pregnancy and breastfeeding.
Guide, Part II, Section 2. McGraw Hill, New York, 2007.
Makarechian N, Agro K, Devline J, Trepanier E,
Nava-Ocampo AA, Talaie H, Koren G: Systematic
Kozer E, Nikfar S, Costei A, Boskovic R, Nulman I,
Koren G, Einarson RT: Association between
review of randomized controlled trials and cohort
Koren G: Aspirin consumption during the first
moderate alcohol consumption during pregnancy and
studies on pregnancy outcome following antiretroviral
trimester of pregnancy and congenital anomalies:
spontaneous abortion, stillbirth and premature birth:
treatment in pregnancy. In: The Evidence-Based,
a meta-analysis. In: The Evidence-Based, A-to-Z
A meta-analysis. In: The Evidence-Based, A-to-Z
A-to-Z Clinician’s Pocket Guide, Part II, Section 4.
Clinician’s Pocket Guide, Part II, Section 4.
Clinician’s Pocket Guide, Part II, Section 3. McGraw
McGraw Hill, New York, 2007.
McGraw Hill, New York, 2007.
Hill, New York, 2007.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 43
Nikfar S, Abdollahi M, Moretti EM, Magee AL, Koren G:
Nulman I, Sussman R, Farber N, Chitayat D, Koren G:
Raman-Wilms L, Tseng Lin-in A, Wighardt S, Einarson RT,
Use of proton pump inhibitors during pregnancy and
Fetal malformations associated with drugs and
Koren G: Fetal genital effects of first-trimester sex
rates of major malformations: a meta-analysis. In: The
chemicals: visualization by sonography/fetal MRI. In:
hormone exposure: a meta-analysis. In: The
Evidence-Based, A-to-Z Clinician’s Pocket Guide, Part
The Evidence-Based, A-to-Z Clinician’s Pocket Guide,
Evidence-Based, A-to-Z Clinician’s Pocket Guide,
II, Section 4. McGraw Hill, New York, 2007.
Part I. McGraw Hill, New York, 2007.
Part II, Section 4. McGraw Hill, New York, 2007.
Seto A, Einarson RT, Koren G: Evaluation of
Nulman I, Izmaylov Y, Staroselsky A, Koren G:
Park-Wyllie L, Mazotta P, Pastuszak A, Moretti EM,
Teratogenic drugs and chemicals in humans. In: The
Beique L, Hunnisett A, Friesen HM, Jacobson S,
brompheniramine safety in pregnancy. In: The
Evidence-Based, A-to-Z Clinician’s Pocket Guide, Part I.
Kasapinovic S, Chang D, Diav-Citrin O, Chitayat D,
Evidence-Based, A-to-Z Clinician’s Pocket Guide,
Nulman I, Einarson RT, Koren G: Birth defects after
Part II, Section 4. McGraw Hill, New York, 2007.
McGraw Hill, New York, 2007.
maternal exposure to corticosteroids: prospective
Seto A, Einarson RT, Koren G: Pregnancy outcome
Nulman I, Knittel-Kerem D, Koren G: Fetal Alcohol
cohort study and meta-analysis of epidemiological
Spectrum Disorder: the central nervous system
studies. In: The Evidence-Based, A-to-Z Clinician’s
following first trimester exposure to antihistamines:
tragedy. In: The Evidence-Based, A-to-Z Clinician’s
Pocket Guide, Part II, Section 4. McGraw Hill, New
a meta-analysis. In: The Evidence-Based, A-to-Z
Pocket Guide, Part I. McGraw Hill, New York, 2007.
York, 2007.
Clinician’s Pocket Guide, Part II, Section 4. McGraw
Nulman I, Koren G: Epilepsy and pregnancy.
Polygenis D, Wharton S, Malmberg C, Sherman N,
In: The Evidence-Based, A-to-Z Clinician’s Pocket
Kennedy D, Koren G, Einarson RT: Moderate alcohol
Sivojelezova A, Gallo M, Bollano E, Boom H, Koren G:
Hill, New York, 2007.
consumption during pregnancy and the incidence
The use of natural health products in pregnancy and
of fetal malformations: a meta-analysis. In: The
lactation. In: The Evidence-Based, A-to-Z Clinician’s
Nulman I, Laslo D, Fried S, Uleryk E, Lishner M,
Evidence-Based, A-to-Z Clinician’s Pocket Guide,
Pocket Guide, Part I. McGraw Hill, New York, 2007.
Koren G: Neurodevelopment of children exposed
Part II, Section 3. McGraw Hill, New York, 2007.
Guide, Part I. McGraw Hill, New York, 2007.
in utero to treatment of maternal malignancy. In:
The Evidence-Based, A-to-Z Clinician’s Pocket Guide,
Part II, Section 4. McGraw Hill, New York, 2007.
44 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
von Dadelszen P, Ornstein MP, Bull SB, Logan AG,
Genotype-specific approaches in therapeutics in
Novel transcriptional control of human CYP3A.
Koren G, Magee AL: Fall in mean arterial pressure
children. Carlton B, Hayden M, Ito S. University of
Ito S. Canadian Institute of Health Research
and fetal growth restriction in pregnancy hypertension:
British Columbia ($105,000 2005-2007)
($340,540 2007-2010)
a meta-analysis. In: The Evidence-Based, A-to-Z
Clinician’s Pocket Guide, Part II, Section 2. McGraw
Hair analysis for cortisol and testosterone. Van Um S,
Pharmacogenetics of adverse drug reactions in
Hill, New York, 2007.
Koren G. The Physicians Services Incorporated
children. Carlton B, Hayden M, Ito S, Koren G.
Foundation ($130,000 2006-2008)
Genome Canada ($350,000 2005-08)
Determinants of renal handling of drugs during
Improving prenatal vitamins to women. Koren G.
The role of placenta in fetal toxicology. Koren G.
development. Koren G. Canadian Institutes of Health
Duchesnay Incorporated ($400,000 2004-2007)
FUNDING
Canadian Institutes of Health Research
($584,309 2007-2011)
Research ($583,800 2003-2008)
Neurodevelopment after fetal exposure to supradose
Drugs and human milk. Ito S. Canadian Institutes of
diclectin. Koren G, Nulman I. Duchesnay Incorporated
Health Research ($376,323 2007-2010)
($480,000 2005-2008)
Drugs and human milk. Ito S. Canadian Institutes of
New Emerging Team (NET) grant. Koren G, Brien J.
Health Research ($645,998 2002-2007)
Canadian Institutes for Health Research
($1,250,000 2002-2007)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 45
Dr. Darcy Fehlings
DIVISION HEAD
Dr. Darcy Fehlings
FULL-TIME
Dr. Douglas Biggar
Dr. Elizabeth Jimenez
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Tamarah Kagan-Kushnir
Alvin Loh
Laura McAdam
Anne Kawamura
Golda Milo-Manson
Angela Orsino
Dr. Wendy Roberts
Dr. Jay Rosenfield
Dr. Peter Rumney
PART-TIME AND/OR
COMMUNITY PHYSICIANS
Dr. Janine Flanagan
Dr. Cynthia Goldfarb
Dr. Mark Handley-Derry
Dr. Nicola Jones-Stokreef
Dr. Peggy Kirkpatrick
Dr. Donal O’Leary
Dr. Anne Richards
Dr. Clive Schwartz
Dr. David Shawn
Dr. Diann Superina
CROSS-APPOINTEES/
SCIENTIFIC STAFF
Dr. Colin Macarthur
Dr. Patricia McKeever
Division of Developmental Paediatrics
OVERVIEW
The division members actively lead and participate in
PUBLICATIONS
The Division of Developmental Paediatrics is situated
applied clinical research in child development and
Angus J, Paszat LF, McKeever P, Trebilcock A, Shivji F,
at Bloorview Kids Rehab. The division consists of
rehabilitation, in association with the Bloorview
Edwards B: Pathways to breast cancer diagnosis
11 full-time physicians as well as a strong community
Research Institute led by Dr. Colin MacArthur. Two
and treatment: exploring the social relations of
section of developmental paediatricians. The main
exciting projects initiated this year are the CIHR-funded
diagnostic delay. Texto and Contexto Enfermagem
clinical focus of the division is on childhood
research evaluating the long-term effectiveness of
2007: 16(4): pp 591-598.
developmental disorders such as cerebral palsy,
botulinum toxin injections in children with cerebral
and autism spectrum disorders. In addition, there
palsy, and the identification of Toronto as a research
Au H, Harrison M, Ahmet A, Orsino A, Beck C, Tallett S,
is a strong rehabilitation component with the acquired
site in the North American Autism Treatment Network.
Gans M, Birken C: Residents as health advocates:
year, the division welcomed Dr. Angela Orsino, a
HONOURS AND AWARDS
a child advocacy initiative at the University of Toronto.
developmental paediatrician whose clinical expertise
Fehlings D: Inaugural Holder, Bloorview Children’s
Paediatrics and Child Health 2007: 12(7): pp 567-571.
brain injury and neuromuscular programs. This
focusses on children with autism spectrum disorders.
the development, implementation and evaluation of
Hospital Foundation/University of Toronto Chair in
Developmental Paediatrics, 2007.
Within the division, there is a strong commitment
Bonati MT, Russo S, Finelli P, Valsecchi MR, Cogliati F,
Cavalleri F, Roberts W, Elia M, Larizza L: Evaluation of
to education. Under the leadership of Dr. Golda
Macarthur C: Inaugural Holder, Bloorview Children’s
Milo-Manson as program director, the fully accredited
Hospital Foundation/University of Toronto Chair in
autism traits in Angelmans syndrome: a resource to
unfold autism genes. Neurogenetics 2007: 8(3):
subspecialty residency program in Developmental
Paediatric Rehabilitation, 2007.
pp 169-178.
also a strong commitment to training paediatric
McKeever P: Inaugural Holder, Bloorview Kids
Carnevale FA, Macdonald ME, Bluebond-Langner M,
and psychiatry residents and medical students
Foundation/University of Toronto Childhood
McKeever P: Using participant observation in pediatric
in applied child development.
Chair in Disability Studies, 2007.
Paediatrics is the largest in Canada. There is
health care settings: ethical challenges and solutions.
Journal of Child Health Care 2008: 12(1): pp 18-32.
An exciting event for the division was the creation in
Roberts W: Division of Developmental
2007 of the Bloorview Children’s Hospital Foundation/
Paediatrics Faculty Teaching Award, 2008.
University of Toronto Endowed Chair in Developmental
Paediatrics. Dr. Darcy Fehlings, Division Head, is the
Schwartz C: Dr. R H A Haslam Pre-Clerkship Teaching
inaugural holder of this leadership chair.
Award for Excellence in Pre-Clerkship Teaching, 2008.
FELLOWS
Dr. Ghassan Abu Kuwaik
Dr. Kassia Johnson
Dr. Sharon Smile
Dr. Lyn Sonnenberg
ADMINISTRATIVE STAFF AT
BLOORVIEW KIDS REHAB
Merlene Chin
Deborah Horner
Joanne Jenah
Romana Karnetova
ADMINISTRATIVE STAFF
Maureen Hodge
Barbara Zimnowodzki
Epstein I, Stevens S, McKeever P, Baruchel S:
Using a puppet to elicit talk with children.
Nursing Inquiry 2008: 15(1): pp 49-56.
Huertas-Ceballos, Logan S, Bennett C, Macarthur C:
Gibbins S, Stevens S, McGrath P, Yamada J, Beyene J,
Harrop A, Brant R, Ghali W, Macarthur C: Injury
Breau L, Camfield C, Finley A, Franck L, Johnston C,
mortality rates in native and non-native children:
Psychosocial interventions for recurrent abdominal
Howlett A, McKeever P, O’Brien K, Ohlsson A:
a population-based study. Public Health Reports
pain (RAP) and irritable bowel syndrome (IBS) in
Comparison of pain responses in infants of different
2007: 122: pp 339-346.
childhood. Cochrane Database Systems Review 2008:
1: CD003014.
gestational ages. Neonatology 2008: 93: pp 10-18.
Hewitt A, Macarthur C, Raina P: The role of evidence
Gibson B, McKeever P: Men on the margin:
in public health policy: an example of linkage and
Kingsnorth S, Healy H, Macarthur C: Preparing for
a Bourdieusian examination of living into adulthood
exchange in the prevention of scald burns. Health
adulthood: a systematic review of life skill programs
with muscular dystrophy. Social Science and
Care Policy 2007: 3: pp 59-66.
for youth with physical disabilities. Journal of
Adolescent Health 2007: 41: pp 323-332.
Medicine 2007: 65(3): pp 505-517.
Hudak P, McKeever P, Wright JG: Unstable
embodiments: a phenomenological interpretation of
Kolski HK, Hawkins C, Zatz M, de Flavia P, Biggar WD,
technology, and place: social and ethical implications
patient satisfaction with treatment outcome. Journal
Alman B, Vajsar J: Diagnosis of limb-girdle muscular
of long-term dependency on medical devices. Ethics,
of Medical Humanities 2007: 28(1): pp: 1041-3545.
dystrophy 2A by immunohistochemical techniques.
Gibson B, Upshur R, Young N, McKeever P: Disability,
Neuropathology 2008: 28(3): pp 264-268.
Place and Environment 2007: 10(1): pp 7-28.
Huertas-Ceballos, Logan S, Bennett C, Macarthur C:
Guerriere D, Wong A, Croxford R, Leong V, McKeever P,
Dietary interventions for recurrent abdominal pain
Moessner R, Marshall CR, Sutcliffe JS, Skaug J,
Coyte P: Costs and determinants of privately-financed
(RAP) and irritable bowel syndrome (IBS) in childhood.
Pinto D, Vincent J, Zwaigenbaum L, Fernandez B,
home-based health care in Ontario, Canada. Health
Cochrane Database Systems Review 2008: 1:
Roberts W, Szatmari P, Scherer SW: SHANK3
and Social Care in the Community 2008: 16(2):
CD003019.
mutations to autism spectrum disorder. American
Journal of Human Genetics 2007: 81(6): pp 1289-1297.
pp 126-136.
Huertas-Ceballos, Logan S, Bennett C, Macarthur C:
Han R, Ungar W, Macarthur C: Cost effectiveness
Pharmacological interventions for recurrent abdominal
Narayanan U, Knights S, Weir S, Livingston M,
analysis of a proposed public health legislative/
pain (RAP) and irritable bowel syndrome (IBS) in
Fehlings D: Does the health status of caregivers
educational strategy to reduce tap water scald injuries
childhood. Cochrane Database Systems Review 2008:
influence their perception of the health-related quality
in children. Injury Prevention 2007: 13: pp 248-253.
1: CD003017.
of life of children with severe non-ambulatory cerebral
palsy? Developmental Medicine and Child Neurology
2007: 49(111): pp 31-21.
48 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Narayanan U, Weir S, Smith J, Fehlings D: Impact of
Stevens B, McGrath P, Gibbins S, Beyene J, Breau L,
Yantzi NM, Rosenberg MW, McKeever P: Getting out of
comorbidities on the health-related quality of life of
Camfield C, Finley A, Franck L, Howlett A, Johnston C,
the house: the challenges mothers face when children
children with severe non-ambulatory cerebral palsy.
McKeever P, O’Brien K, Ohlsson A, Yamada J:
have long-term care needs. Health and Social Care in
Developmental Medicine and Child Neurology 2007:
Determining behavioural and physiological responses
the Community 2007: 15(1): pp 45-55.
49(111): p 68.
to pain in infants at risk for neurological impairment.
BOOKS AND BOOK CHAPTERS
Pain 2007: 127: pp 94-102.
Peter E, Spalding K, Kenny N, Conrad P, McKeever P,
England K, Eakin J, Gastaldo D, McKeever P:
Macfarlane A: Neither seen nor heard: children and
Sutcliffe TL, Gaetz WC, Logan WJ, Cheyne DO,
Neoliberalizing home care: managed competition and
home care policy in Canada. Social Science and
Fehlings DL: Cortical reorganization after modified
restructuring home care in Ontario. In Neo-liberalization:
Medicine 2007: 64(8): pp 1624-1635.
constraint-induced movement therapy in pediatric
States, Networks, Peoples (England K, Ward K, eds.).
hemiplegic cerebral palsy. Journal of Child Neurology
Blackwell Publishing Ltd., London, UK, 2007.
Pope E, Krafchik B, Macarthur C, Stempak D,
2007: 22(11): pp 1281-1287.
FUNDING
Stephens D, Weinstein M, Ho N, Baruchel S: Oral
versus high-dose pulse corticosteroids for problematic
Tallett S, Lingard L, Leslie K, Pirie J, Jeffries A,
A molecular genetic study of autism and related
infantile hemangiomas: a randomized, controlled trial.
Spero L, Schneider R, Hilliard R, Rosenfield J,
phenotypes in extended pedigrees. Szatmari P,
Hellman J, Mian M, Hurley J: Measuring educational
Zwaigenbaum L, Scherer S, Vincent J, Roberts SW,
workload: a pilot study of paper-based and PDA tools.
Goldberg J, Mahoney W, Fernandez B. Canadian
Medical Teacher 2008: 30(3): pp 296-301.
Institutes of Health Research ($550,000 2006-2011)
chronic abdominal pain: role of selected laboratory
Wright V, Rosenbaum P, Goldsmith C, Law M, Fehlings
An evaluation of the long-term effectiveness of
investigations (stool ova and parasites, complete
D: How do changes in body functions/structures,
botulinum toxin in children with spastic cerebral palsy.
Fehlings D, Goldsmith C, Narayanan U, Rosenbaum P,
Pediatrics 2007: 119: pp 1239-1247.
Soon G, Saunders N, Ipp M, Sherman PM, Macarthur C:
Community-based case-control study of childhood
blood count, and erythrocyte sedimentation rate).
activity, and participation relate? A study of children
Journal of Pediatric Gastroenterology and Nutrition
with cerebral palsy (CP). Developmental Medicine and
Wright W. Canadian Institutes of Health Research
2007: 44: pp 524-526.
Child Neurology 2008: 50: pp 283-289.
($425,956 2008-2012)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 49
A qualitative observational study of resident oral
Books for siblings of children with autism. Johnson K,
Critical reflections on ambulatory training for children
paediatric developmental case presentations.
McKeever P, Kawamura A. Bloorview Research
with cerebral palsy. Gibson B, Wright V, Yong NL,
Orsino A, Kawamura A, Lingard L, Fehlings D.
Institute Seed Grant ($5,500 2007-2008)
McKeever P, McLaren C, Fehlings D. Health Care,
Technology and Place: Interdisciplinary Capacity
Bloorview Research Institute ($10,553 2008-2009)
Canadian Injury Indicators Development, Phase II.
Enhancement Team Grant ($8,000 2007-2008)
Autism genome project. Scherer SW, Szatmari P,
Pike I, Macpherson A, Macarthur C, Warda L, Babul S,
Paterson AD, Vincent JB, Zwaigenbaum L, Roberts W,
Goodman D, Raina P. Canadian Institutes of Health
Development of an indicator of the impact of assistive
Wellington SR, Fernandez BA, Miller FA, Hallmayer JF.
Research ($225,000 2008-2011)
devices on children with disabilities and their families.
Ryan S, Campbell K, McKeever P, Montpetit K,
Genome Canada ($15,611,534 2005-2009)
Cerebral Palsy Outcomes Project (CPOP). Fehlings D,
Perkin S, Rigby P, Roxborough L, Stevens J. Canadian
Autism spectrum disorders: pathways to better
Kolaski K, Gaebler-Spira D, Kuroda M, Msall M,
Institutes of Health Research ($225,000 2008-2011)
outcomes. Szatmari P, Bryson SE, Fombonne E,
Thornton L, Moberg-Wolff E, Krach L, Hurvitz E.
and Research Institute ($100,000 2008-2011)
Zwaigenbaum L, Smith I, Waddell C, Vaillancourt T,
American Academy for Cerebral Palsy and
Mirenda P, Roberts W, Volden J. Canadian Institutes
Developmental Medicine ($25,000 2007-2008)
Discriminating autism from other atypical patterns of
development in a community sample. Roncadin C,
of Health Research ($2,125,000 2004-2009)
Clowning around: the effects of therapeutic clowning
Roberts W, Niccols A, Brian J, Bryson S, Smith I,
Autism Treatment Network: Co-operative multicentre
on patients and nurses in a paediatric rehabilitation
Zwaigenbaum L. The Ontario Mental Health
program for research and treatment of autism.
facility. Kingsnorth S, McKeever P, Blaine S. Bloorview
Foundation (Type A Grant) ($142,005 2008-2010)
Roberts W, Loh A, Kawamura A, Feigenbaum A,
Children’s Hospital Foundation ($24,985 2008-2009)
Early developmental trajectories in autism.
Weiss S, Marcon C, Goldfarb C, Berall G, Bradley E,
Brian J, Freeman N, Atkinson A, Taylor M, Stinson J,
Costs incurred by families of children newly diagnosed
Zwaigenbaum L, Bryson SE, Roberts S, Smith I,
Mitchell S, Kawamura A, Green P. Autism Speaks
with cancer. Stevens B, Tsimicalis A, Greenberg M,
Szatmari P, Vaillancourt T. Canadian Institutes of
($450,000 2008-2010)
McKeever P, Ungar W, Guerriere D, Agha M. National
Health Research ($932,585 2006-2011)
Cancer Institute of Canada ($330,712 2006-2008)
50 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Enhancing inter-subjectivity in infants at high risk for
From knowledge generation to knowledge translation:
Genome wide DNA methylation profiling in autism.
autism. Bryson S, Brian J, Smith I, Zwaigenbaum L,
a systems approach to reducing the burden of injury in
Weksberg R, Roberts SW, Scherer S. Canadian
Roberts SW. Autism Speaks ($638,006 2007-2010)
Canada. Macarthur C, Raina P. Canadian Institutes of
Institutes of Health Research ($649,518 2008-2011)
Health Research ($942,361 2003-2008)
HCTP & The Change Foundation Strategic Alliance.
Evaluating outcomes associated with multidisciplinary
care for children with cerebral palsy using clinical
Functional status outcome indicators for young
McKeever P, Coyte PC. The Change Foundation
practice improvement (CPI) methodology. Damiano D,
children with cerebral palsy: evaluation of the
(2003-2008 $200,000)
Chambers H, Revivo G, Brunstrom J, Horn S,
comparative abilities of two internationally-recognized
Gassaway J, Krach L, Gormley M, Novacheck T,
measures to detect change, and determination of
Identity, embodiment and heart transplantation:
Matthews D, Chang F, Stevenson R, Abel M,
benchmarks for clinically important change. Wright V,
a phenomenologically-informed exploration. Ross H,
McLaughlin J, Bjornson K, Rathjen K, Delgado M,
Stratford P, Goldsmith C, Rigby P, Fehlings D,
McKeever P, Shildrick M, Poole J. Advanced Heart
Dabrowski E, Gaebler-Spira D, Dias L, Narayanan U,
Rosenbaum P. Canadian Institutes of Health
Failure Fund (2008-2009 $75,000)
Fehlings D, Graham K, Koman A. American Academy
Research ($174,565 2008-2010)
Inappropriate living environments for children
for Cerebral Palsy and Developmental Medicine
Clinical Research Planning Grant ($29,000 2006-2007)
Functional outcomes following orthopaedic surgery
with acquired brain injury. Law M, Colantonio A,
based on gait laboratory versus observational gait
DeMatteo C, Macarthur C. Ontario Neurotrauma
Evaluation of the reliability, validity and
analysis in ambulatory children with cerebral palsy:
Foundation ($150,000 2005-2007)
responsiveness of the Kinematic Dystonia measure in
a randomized controlled trial. Narayanan U, Willan A,
children with upper extremity dystonia. Kawamura A,
Wedge J, Fehlings D. Pediatric Orthopaedic Society
Fehlings D, Morris A, Campbell K. Bloorview Research
of North America (POSNA) ($31,000 2006-2008)
Interdisciplinary capacity enhancement grant for
“Health Care, Technology and Place”: a CIHR Centre
for Research Development. Coyte PC, McKeever P.
Institute Seed Grant ($16,652 2007-2008)
Functional outcomes following orthopaedic surgery
Canadian Institutes of Health Research
Evaluation of quality of movement in ambulatory
based on gait laboratory versus observational gait
($1,000,000 2003-2008)
children with cerebral palsy: validity and sensitivity
analysis in ambulatory children with cerebral palsy:
to change of the quality FM. Rosenbaum P,
a pilot randomized controlled trial. Narayanan U,
Wright V, Mesterman R, Fehlings D, Kim M.
Fehlings D, Willan A, Wedge J, Redekop S.
McKeever P, Hodnett E, Carter M, Vanderby S,
Physicians’ Services Incorporated Foundation
Bloorview Research Institute Seed Grant
Adams A, Theodore D, Jewell S, Koziel N.
($125,000 2007-2009)
Competition ($25,015 2006-2007)
Philips Electronics ($134,578 2006-2008)
Kids’ ambient MRI suite conversion study. Babyn P,
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 51
Medical Technologies Research and Commercialization
Role of telecommunication in augmentative
The efficacy of an intelligent prompting system to
Collaborative. Phipps D, Macarthur C, Boehm L,
and alternative communications. Macarthur C.
develop self-care activities in children with autism.
Duschenne-Smith J. Canadian Institutes of Health
Bell Canada ($150,000 2005-2007)
Mihailidis A, Roberts SW, Polatajko H, Chau T.
SickKids Foundation ($129,470 2007-2009)
Research, National Sciences and Engineering
Research Council of Canada and Social Sciences and
School, home and neighbourhood accessibility:
Humanities Research Council ($615,000 2005-2008)
physically disabled children’s assessments (The
The experience for autism over the course of paediatric
ScHaN Project). McKeever P, Ruddick S, Dunn J, Yantzi
development. Nicholas D, Roberts SW, McKeever P.
Long-term follow-up of boys with DMD.
N, Young N. Canadian Institutes of Health Research
SickKids Foundation ($129,821 2008-2010)
Leshner R, Biggar D. Co-operative International
($360,768 2008-2011)
The experience of maternal and family care for
Neuromuscular Research Group Washington, DC
($400,000 2007-2012)
Strategic Training Program Grant for “Health Care,
autism over the course of paediatric development.
Technology and Place.” McKeever P, Coyte PC.
Nicholas D, Roberts SW, McKeever P. Social
Neuroimaging and frontal lobe function in children
Canadian Institutes of Health Research
Sciences and Humanities Research Council
with autism. Taylor M, Roberts SW, Donner EJ,
($2,146,250 2002-2009)
of Canada ($154,000 2008-2010)
The development and evaluation of the HAT-D: a
The lived experiences of mothers of children with
discriminative tool differentiating types of hypertonia
autism. Nicholas D, Roberts SW, McKeever P.
Outcomes research in paediatrics. Parkin P,
in children. Fehlings D, Jethwa A, Macarthur C.
Social Sciences and Humanities Research
Macarthur C. SickKids Foundation ($750,000 2008-2013)
Bloorview Research Institute ($9,606 2006-2007)
Council of Canada ($154,000 2008-2011)
Pain in infants with disabilities: a program of
The development of a virtual reality therapy home-
The paediatric hospital atrium: designers’ intentions
Bayless S, Shroff M. National Alliance Autism
Research ($115,907 2006-2008)
research, phase II. Stevens B, McGrath P, Beyene J,
based system to improve hand usage and function
versus children’s experiences. Adams A, McKeever P,
Breau LM, Camfield CS, Finley GA, Gibbins S,
in children with hemiplegia. Fehlings D, Chau T,
Spalding K. Canadian Institutes of Health Research
Howlett A, Johnston C, McKeever P, O’Brien K,
Lam-Damji S, Tse K. Bloorview Research Institute
($291,376 2005-2008)
Ohlsson A. Canadian Institutes for Health Research
Seed Grant ($24,972 2006-2008)
($676,202 2003-2008)
52 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
The reliability and validity of the Paediatric Autism
Validation of accelerometry as a measure of physical
Early Diagnosis Tool (PAED) –a pilot project. Roberts W,
activity and inactivity in children with chronic diseases.
Green P, Shouldice M, Wright V. Bloorview Research
Feldman B, Stephens S, Schneidermna-Walker J,
Institute Seed Grant ($17,400 2006-2008)
Biggar WD, McCrindle B, Longmuir P. Canadian
Institutes of Health Research ($60,000 2008-2009).
Training program in autism research. Fombonne E,
Bryson S, Paterson A, Scherer S, Roberts W,
Western Canada standards of care for Duchenne
Szatmari P, Smith I, Moore C. Canadian Institutes
muscular dystrophy. Mah J, Moore M, Biggar WD.
of Health Research, National Alliance for Autism
Porticus Foundation ($23,125 2008)
Research, Fonds de la Recherche en SantГ© du
QuГ©bec ($1,440,000 2003-2009)
Women’s income levels and diagnostic delay in breast
cancer. Angus J, Bondy S, Paszat L, McKeever P.
Understanding chronic pain in infancy. Stevens BJ,
Social Sciences and Humanities Research Council
Asztalos E, McKeever P, Gibbins S, Pillai Riddell R,
of Canada ($90,620 2004-2007)
Katz J. Canadian Institutes of Health Research
(2005-2008 $141,674)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 53
Dr. Mark Palmert
DIVISION HEAD
Dr. Mark R. Palmert
Dr. Etienne Sochett
Dr. Diane Wherrett
FULL-TIME
Dr. Denis Daneman
Dr. Jill Hamilton
Dr. Kusiel Perlman
PART-TIME
Dr. Jacqueline Curtis
Dr. Susan Kirsch
Dr. Stacey Urbach
GYNAECOLOGY
Dr. Lisa Allen
Dr. Nicolette Caccia
Dr. Sari Kives
Dr. Melanie Ornstein
GYNAECOLOGY FELLOW
Dr. Kerith Lucco
HONORARY
Dr. Robert Ehrlich
CROSS-APPOINTEES
Dr. Amira Klip
Dr. Joanne Rovet
SUBSPECIALTY RESIDENTS/
CLINICAL FELLOWS
Dr. Abdulla Aljunaibi
Dr. Bojana Babic
Dr. Corinna Grasemann
Dr. Ara Healey
Dr. Dror Koltin
Dr. Clodagh O’Gorman
Dr. Constantine Samaan
Division of Endocrinology
OVERVIEW
Recent initiatives include the development of
HONOURS AND AWARDS
2007-08 was a highly productive time for the Division
pathways for the care of children with thyroid cancer
Allen L: University of Toronto Department of
of Endocrinology with ongoing development of existing
in collaboration with Oncology, Otolaryngology and
Obstetrics and Gynaecology Chairs’ Award for
programs and new innovations. We have had in 10
Nuclear Medicine; enhancement of our program
Excellence in Undergraduate Teaching, 2007.
trainees in our subspecialty training program: five
designed to provide care to survivors of paediatric
Canadian, two Irish, one Israeli, one Costa Rican
cancer who develop endocrine abnormalities; further
Hamilton J: NovoNordisk Young Investigator
and one from the UAE. We also welcomed Dr. Mark
development of our hypothalamic obesity program, with
Career Development Award, 2008.
Palmert as the new division head.
inclusion of a small number of patients with multiple
Our areas of clinical focus continue to be: (i) diabetes:
medical problems stemming from being overweight;
Hamilton J: The Hospital for Sick Children Department
and establishment of a new focus on disorders of puberty.
of Paediatrics Richard Rowe Junior Faculty Award for
our comprehensive program provides ongoing care
Excellence in Clinical Medicine, 2007.
to nearly 1,000 children and teens with diabetes,
Our research efforts have targeted the following
including a program for comprehensive assessment
areas: (i) prediction and prevention of Type 1 diabetes:
Klip A: Editor-in-chief–The American Journal
and treatment for adolescents with chronically
our group is involved in the multinational TrialNet
of Physiology–Endocrinology and Metabolism
poor diabetes control; (ii) general endocrinology
and TRIGR study groups; (ii) implications of insulin
Physiology, 2007.
emphasizing the areas of growth, thyroid disease,
resistance and obesity in children and adolescents
intersex conditions and reproductive health; (iii)
and the evolution of these abnormalities in young
Klip A: Glassman Lecturer, Hebrew University,
calcium: the Calcium-Bone and Osteoporosis Clinics
children; (iii) study of the factors affecting metabolic
Jerusalem, 2008.
assesses children with abnormal bone health from
control and the early complications of diabetes;
a wide variety of causes; and (iv) the gynaecology
(iv) psychosocial and psychological outcomes in
PUBLICATIONS
section; which provides care to pre-teen and
diabetes and other endocrine disorders; (v) evaluation
Aanstoot H-J, Anderson BJ, Daneman D, Danne T,
adolescent girls across a wide spectrum of disorders.
of disorders of calcium and bone mineral metabolism
Donaghue T, Kaufman F, RГ©a RR, Uchigata Y: The
in paediatrics. A new focus is clinical and laboratory
global burden of youth diabetes: perspectives and
based investigation of complex genetic traits, with an
potential, a charter paper. Pediatric Diabetes 2007:
emphasis on identification of genes that regulate the
8: pp 1-44.
timing of puberty.
SUBSPECIALTY RESIDENTS/
CLINICAL FELLOWS
Dr. Rayzie Shulman
Dr. Julieta Solis Chacon
RESEARCH FELLOWS
Dr. Shazhan Amed
Dr. Meranda Nakhla
ADMINISTRATIVE STAFF
Joyce Robinson
Elizabeth Rodgers
Minet Smith
Zarine Tilak
DГ­az M, Antonescu CN, Capilla E, Klip A, Planas JV:
Allen L, Brewer M, Bryson P, Evans G, Frappier JY,
Cherney DZ, Miller JA, Scholey JW, Bradley T, Slorach C,
Jamieson MA, Lynde C, Murphy KJ, Provencher DM,
Curtis JR, Dekker MG, Nasrallah R, Hebert RL,
Fish glucose transporter (GLUT) -4 differs from
Shier M, Steben M, Lerch R, Lalonde A, Senikas V:
Sochett EB: The effect of cyclooxygenase 2 inhibition
rat GLUT-4 in its traffic characteristics but can
Canadian consensus guidelines on human
on renal hemodynamic function in humans with Type 1
translocate to the cell surface in response to insulin
papillomavirus. Obstetrics and Gynaecology Canada
diabetes. Diabetes 2008: 57 (3): pp 688-695.
in skeletal muscle cells. Endocrinology 2007: 148:
pp 5248-5257.
2007: 29: pp S1-S59.
Colton P, Olmsted M, Daneman D, Rydall A, Rodin G:
Amed S, Delvin E, Hamilton J: Variation in growth
Five year prevalence and persistence of disturbed
Daneman A, Daneman D: McCune-Albright syndrome.
hormone immunoassays in clinical practice in Canada.
eating behaviour and eating disorders in girls with type
Journal of Pediatric Endocrinology and Metabolism
Hormone Research 2008: 69: pp 290-294.
1 diabetes. Diabetes Care 2007: 30: pp 2861-2862.
2007: 20: p 1265.
Antonescu CN, DГ­az M, Femia G, Planas JV, Klip A:
Colton P, Olmsted M, Daneman D, Rydall A, Rodin G:
Dugani CB, Randhawa VR, Cheng AW, Patel N, Klip A:
Clathrin-dependent and independent endocytosis
Natural history and predictors of eating disturbances
Selective regulation of the perinuclear distribution of
of glucose transporter 4 (GLUT4) in myoblasts:
in girls with type 1 diabetes. Diabetic Medicine 2007:
glucose transporter 4 (GLUT4) by insulin signals in
regulation by mitochondrial uncoupling. Traffic 2008:
24: pp 424-429.
muscle cells. European Journal of Cell Biology 2008:
87(6): pp 337-351.
April 24 [Epub ahead of print].
Conwell L, Forrest C, Allen U, Daneman D: Necrotizing
Guilbert E, Broditsky R, Black A, Kives S, Leboeuf M,
Cameron FJ, Northam EA, Ambler GR, Daneman D:
fasciitis in adolescents with poorly controlled Type 1
Routine psychological screening in youth with type 1
diabetes mellitus: report of two cases. Pediatric
Mirosh M, Senikas V, Wagner MS, Weir E, York-Lowry J,
diabetes and their parents: a notion whose time has
Diabetes 2007: 8: pp 397-400.
Reid R, Trussell J: Canadian consensus guidelines on
continuous and extended hormonal contraception.
come? Diabetes Care 2007: 30: pp 2716-2724.
Conwell L, Pope E, Artiles A, Mohanta A, Daneman A,
Journal of Obstetrics and Gynaecology Canada 2007:
Daneman D: Dermatological complications of
29: pp S1-S32.
continuous subcutaneous insulin infusion (CSII) in
children and adolescents. Journal of Pediatrics 2008:
152: pp 622-628.
56 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Hiraki LT, Hamilton J, Silverman ED: Measuring
Koltin D, Daneman D: Dead-in-bed syndrome –
Rachmiel M, Buccino J, Daneman D: Exercise
permanent damage in pediatric systemic lupus
a diabetes nightmare. Pediatric Diabetes 2008:
and type 1 diabetes mellitus in youth: review
erythematosus. Lupus 2007: 16: pp 657-662.
May 21 [Epub ahead of print].
and recommendations. Pediatric Endocrinology
Hodges CA, Palmert MR, Drumm ML: Infertility in
Makitie O, Toiviainen-Salo S, Marttinen E, Kaitila I,
females with cystic fibrosis is multifactorial: evidence
Sochett E, Sipila I: Metabolic control and growth
Rachmiel M, Kives S, Atenafu E, Hamilton J: Primary
from mouse models. Endocrinology 2008: 149(6):
during exclusive growth hormone treatment in X-linked
amenorrhea as a manifestation of polycystic ovarian
pp 2790-2797.
hypophosphatemic rickets. Hormone Research 2008:
syndrome in adolescents: a unique subgroup?
69(4): pp 212-220.
Archives of Pediatrics and Adolescent Medicine 2008:
Reviews 2007: 5: pp 656-665.
162: pp 521-525
HPV Consensus Guidelines Committee (Allen L,
Brewer M, Bryson P, Evans G, Frappier JY, Jamieson MA,
Nadkarni D, Spitzer RF, Colgan T, Kives S, Allen L:
Lynde C, Murphy KJ, Provencher DM, Shier M,
Uterine asymmetry and dysmenorrhea in a young
Robertson D, Kives S: Adolescent consent in
Steben M, Lerch R, Lalonde A, Senikas V): Canadian
woman. Journal of Obstetrics and Gynaecology
reproductive and sexual health decision-making:
consensus guidelines on human papillomavirus.
Canada 2008: 30: pp 301-302.
should there be an arbitrary age of consent or
should it be based on the “evolving capacities
Journal of Obstetrics and Gynaecology Canada 2007:
29: pp S1-S59.
Ishikura S, Koshkina A, Klip A: Small G proteins in
O’Connor DL, Khan S, Wishuhm K, Vaughan J,
of the child”? Journal of Pediatric and Adolescent
Jefferies A, Campbell D, Asztalos E, Feldman M,
Gynaecology 2008: 21: pp 47-51.
Rovet J, Westall C, Whyte H: Growth and nutrient
Roher N, Samokhvalov V, DГ­az M, MacKenzie S, Klip A,
insulin action: rab and rho families at the crossroads
intakes of human milk-fed premature infants
of signal transduction and GLUT4 vesicle traffic. Acta
provided with extra energy and nutrients after
Planas JV: The proinflammatory cytokine tumour
Physiology 2008: 192: pp 61-74.
hospital discharge: a pilot randomized controlled
necrosis factor increases the amount of glucose
trial. Pediatrics 2007: 121: pp 766-776.
transporter-4 at the surface of muscle cells
independently of changes in Interleukin-6.
Endocrinology 2008: 149(4): pp 1880-1889.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 57
Segal P, Hamilton J, Sermer M, Connelly P, Hanley A,
Wells GD, Noseworthy MD, Hamilton J, Tein I:
Banerjee S, Tran K, Li H, Cimon K, Daneman D,
Zinman B, Retnakaran R: Maternal obesity and familial
Skeletal muscle dysfunction in obesity: new ideas
Simpson S, Campbell K: Short-acting insulin analogs
history of diabetes have opposing effects on infant
and concepts. Canadian Journal of Neurological
for diabetes mellitus: meta-analysis of clinical
birthweight in women with mild glucose intolerance in
Sciences 2008: 35: pp 31-40.
outcomes and assessment of cost-effectiveness
BOOKS AND BOOK CHAPTERS
Technologies in Health, Ottawa, 2007.
(Technology Report 87). Canadian Agency for Drug
pregnancy. Journal of Maternal-Fetal and Neonatal
Medicine 2008: 21: pp 73-79.
Al-Abdulrazzaq D, Allen LM: Pediatric and adolescent
Shulman DI, Francis GL, Palmert MR, Eugster EA,
gynecology. In: The Hospital for Sick Children
Caccia N, James A: Planned delivery by caesarean
for the Lawson Wilkins Pediatric Endocrine Society
Handbook of Pediatrics, 11th Edition. Elsevier,
section may be hazardous for mother and baby. In:
Drug and Therapeutics Committee: Use of aromatase
Canada, 2007.
AboutKidsHealth, www.aboutkidshealth.ca, 2008.
Allen LM. Management issues in child gynecology. In:
Hamilton J, Hozjan I: Lumps, bumps and other
Progress in pediatric Urology, Volume 10 (Pajpai M,
swellings: lymphatics and skin issues. In: Turner
inhibitors in children and adolescents with disorders
of growth and adolescent development. Pediatrics
2008: 121(4): pp 975-983.
Gearhart JP, Mouriquand PDE, Mitra DK, Radhakrishan J,
Syndrome: Across the Lifespan. (Hamilton J, Hozjan I,
Spitzer R, Salle P, Wherrett D, Colgan T, Chitayat D,
Mathews R, Etker S, eds.). Penwel Publishers,
eds.). Castlemore Graphics, Brampton, Ontario, 2008.
Dodge J, Allen L: Luteoma of pregnancy presenting
New Delhi, 2008.
with virilization in the female infant. Journal of
Hamilton J, Hozjan I: Turner Syndrome: Across the
Obstetrics and Gynaecology Canada 2007: 29:
Amed S, Hamilton J: When sugar is not so sweet:
Lifespan. Castlemore Graphics, Brampton, Ontario, 2008.
pp 835-840.
diabetes and the metabolic syndrome. In: Turner
Syndrome: Across the Lifespan (Hamilton J, Hozjan I,
Hodges CA, Palmert MR: Genetic regulation of the
Spitzer RF, Caccia N, Kives S, Allen LM: Hysteroscopic
eds.). Castlemore Graphics, Brampton, Ontario, 2008.
variation in pubertal timing. In: When Puberty is
unification of a complete obstructing uterine septum:
Precocious: Scientific and Clinical Aspects
Case report and review of the literature. Fertility and
(Pescovitz OH, Walvoord EC, eds.). Humana Press Inc.,
Sterility 2008: March 5 [Epub ahead of print].
Totowa, NJ, 2007.
58 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Kives S, Lacey J. Normal menstrual physiology.
Bypassing insulin resistance of muscle cells caused
Comparison of continuous versus cyclical use of a
In: Adolescent Health Care: A Practical Guide,
by ceramide, oxidative stress and macrophage-co-
30-MCG ethinyl estradiol 0.15 mg desogestrel oral
5th Edition (Neinstein LS, Gordon CM, Katzman DK,
culture. Klip A. Canadian Diabetes Association
contraceptive pill in adolescents. Allen L, Brown C.
Rosen DS, Woods ER, eds.). Lippincott Williams &
($300,000 2006-2009)
Physicians’ Services Incorporated Foundation
($75,000 2006-2008)
Wilkins, Philadelphia, 2007.
Clinical Co-ordinating Centre for Epidemiology of
Rovet J, Brown R. Congenital hypothyroidism. In:
Diabetes Intervention and Complications (DCCT/EDIC).
Cross-sectional study of overweight in paediatric
Neurogenetic Developmental Disorders: Manifestation
Palmert MR (Principal Investigator until August 2007;
survivors of acute lymphoblastic leukaemia. Nathan
and Identification in Childhood (Mazzocco M, Ross J,
now Consultant). National Institutes of Health/
PC, Urbach SL, Barrera M, Barron M, D’Agostino N,
eds.). MIT Press, Boston, 2007.
National Institute of Diabetes and Digestive and
Staneland P, Charron, Greenberg ML. The University
Kidney Diseases ($54,312,694 2006-2016)
of Toronto, Faculty of Medicine Dean’s Fund
($9,998 2007-2008)
Tran K, Banerjee S, Li H, Cimon K, Daneman D,
Simpson S, Campbell K. Long-acting insulin analogues
Combined diazoxide and metformin therapy in
for diabetes mellitus: meta-analysis of clinical
children with hypothalamic obesity secondary
Evaluation of hepatic function and autoimmunity in
outcomes and assessment of cost-effectiveness.
to craniopharyngioma: a pilot study. Hamilton J,
girls with Turner Syndrome. Hamilton J, McAssey K,
Canadian Agency for Drugs and Technologies in
Daneman D, Ahmet A. Canadian Institutes of
Milkiewicz P, Heathcote J, Norman G (Investigator
Health, Ottawa, 2007.
Health Research ($49,500 2006-2008)
initiated study). Hoffman-La Roche Canada
($23,980 2006-2008)
FUNDING
Comparison of continuous versus cyclic use of a
A phase IV open-label study of predictive markers in
30-MCG ethinyl estradiol 0.15 mg desogestrel oral
Genetic factors that regulate the onset of puberty.
growth hormone deficient and Turner Syndrome
contraceptive pill in adolescents. Allen L, Brown C.
Palmert MR. National Institutes of Health/National
pre-pubertal children treated with SAIZEN. Hamilton J
Azko Nobel – Organon Canada ($24,500 2006-2008)
(Principal Investigator SickKids site). Serono Canada
Institute of Child Health and Human Development
($1,633,256 2005-2010)
Incorporated ($2,400 2005-2008)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 59
Growth hormone therapy and bone quality in
Intracellular compartment plasticity and signal
Post-marketing surveillance program for Nutropin.
paediatric osteoporosis. Sochett E, Grynpas M. Eli
transmission in insulin action. Klip A. Canadian
Hamilton J. Genentech National Co-operative Growth
Lilly Canada ($125,000 2006-2009)
Institutes of Health Research ($759,560 2005-2010)
Study (NCGS) ($45,300 2001-2008)
Hemodynamic modulation in type 1 diabetes. Miller J,
MRI analyses of visuospatial processing deficits
Psychosocial adjustment in genetic males born with
Sochett E, Cherney D. Canadian Institutes of Health
in children born preterm. Rovet J, Desrocher M,
ambiguous genitalia. Wherrett DK. The Hospital for
McAndrews MP. March of Dimes
Sick Children Research Institute Seed Grant
(US$335,945 2007-2010)
($15,590 2001-2008)
for glucose transport. Klip A. Canadian Institutes of
Multiple courses of antenatal corticosteroids for
The comprehensive care clinic for children with central
Health Research ($643,800 2002-2007)
preterm birth study: a five-year follow-up (MACS-5).
tumours at The Hospital for Sick Children: evaluating
Asztalos E, Rovet J. Canadian Institutes of Health
the efficacy of an integrated, multidisciplinary model
Research ($3,585,161 2005-2012)
of care for children with hypothalamic dysfunction.
Research ($105,000 2007-2012)
Hormonal regulation of p38MAPK and its implications
Insulin resistance and beta cell dysfunction in early
Hamilton J, Barrera M, Guger S, Popov T, Schulte F.
childhood: the role of maternal and infant metabolic
National surveillance of non-type 1 diabetes mellitus
Brain Tumour Research Assistance and Information
Zinman B. Canadian Institutes of Health Research
in Canadian children. Hamilton J, Dean H, Amed S,
Network (b.r.a.i.n. Child) ($27,931 2006-2008)
($341,706 2005-2008)
Sellers E, Dannenbaum D, Laubscher L, Booth G.
risk factors. Hamilton J, Hanley A, Retnakaran R,
Canadian Diabetes Association ($97,939 2006-2008)
The genetics and neuroendocrinology of short stature.
Hamilton J (Principal Investigator SickKids site).
Insulin sensitization by muscle contraction pathways:
implications for insulin resistance. Klip A. Canadian
Neuroimaging studies of hippocampal formation in
Lilly International Growth Study (GeNeSIS)
Institutes of Health Research and National Science
children with pre- and post-natal thyroid hormone
($58,542 2002-2008)
Foundation of China - China-Canada Joint Health
insufficiencies. Rovet J, Desrocher M, McAndrews MP,
Research Initiative ($90,000 2006-2009)
Sheard E. Canadian Institutes of Health Research
($728,640 2006-2011)
60 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
The GH Monitor Registry. Hamilton J (Principal
Treatment options for Type 2 diabetes in adolescents
Investigator SickKids site). Serono Canada
and youth (TODAY). Palmert MR (Principal Investigator
Incorporated ($6,200 2008-2010)
until August 2007), Dahms W. National Institutes of
The GLUT4 interactomes and their metabolic
and Kidney Diseases ($3,240,000 2002-2010)
Health/National Institute of Diabetes and Digestive
implications. Klip A. Canadian Institutes of Health
Research ($818,206 2007-2012)
Type 1 diabetes TrialNet–the impact of GAD on
preservation of cell function. Wherrett DK. National
Thyroid hormone insufficiencies and visual perceptual
Institutes of Health (US$450,000 2007-2008)
deficits in preterm infants. Rovet, J, Westall C,
Asztalos E, Perlman K, Heon E. March of Dimes
Type 1 diabetes genetics consortium. Wherrett DK.
(US$253,083 2004-2007)
National Institutes of Health contract with Benaroya
Research Institute (US$15,000 2003-2008)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 61
Dr. Peter Durie
DIVISION HEAD
Dr. Stanley Zlotkin
FULL-TIME
Dr. Peter Durie
Dr. Nicola Jones
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Anne Griffi ths
Simon Ling
Vicky Ng
Paul Pencharz
Philip Sherman
Mary Zachos
PART-TIME
Dr. Glenn Berall
Dr. Carol Durno
Dr. Paul Kortan
Dr. Margaret Marcon
Dr. Gary May
CROSS-APPOINTEES
Dr. Mary Corey
CLINICAL FELLOWS
Dr. Fatma Al-Madhaki
Dr. Tanja Gonska
Dr. Keith Ooi
Dr. Juan Ossa
RESEARCH FELLOWS
Dr. Eric Benchimol
Dr. Juan Gana
Dr. Orlee Guttman
Dr. Seamus Hussey
Dr. Aleixo Muise
Dr. Mary Sherlock
Dr. Dan Turner
Dr. Catharine Walsh
Dr. Thomas Walters
Dr. Eytan Wine
Dr. Jason Yap
Division of Gastroenterology, Hepatology and Nutrition
OVERVIEW
This year, staff and fellows in the division have
Benchimol E: Trainee Scholarship,
The Division of Gastroenterology, Hepatology and
been honoured with awards, fellowships and named
Gastroenterology Research Group and The American
Nutrition is one of the only programs in Canada with a
lectureships, including Canadian Association of
Gastroenterological Association Institute, 2007.
fully integrated specialty program in clinical paediatric
Gastroenterology Visiting Professorship, Fellow of
GI, hepatology, transplantation (liver and small bowel)
the American Society of Nutrition, the Joseph M. West
Gana J: Canadian Child Health Clinician Scientist
and nutrition, and vertical programs in education and
Family Memorial Award, the Levy/Thomson Award for
Program Career Enhancement Program Award, 2008.
research which span the clinical spectrum. The
Outstanding Oral Presentation, the Miriam Neveren
program offers one year of clinical training and two
Memorial Award, the Canadian Child Health Clinician
Gana J: Levy/Thomson Award for Outstanding Oral
research years. The clinical component includes a wide
Scientist Program (CCHCSP) Career Enhancement
Presentation. Gana JC, Roberts EA, Ng VL, Ling SC.
array of experiences including: procedures (endoscopy,
Program Award, and many more. The staff members
Non-invasive diagnosis of esophageal varices in
manometry and calorimetry), inpatient management of
of the division have published over 60 peer-reviewed
children. Gastroenterology residents-in-training (GRIT)
complex patients, including those awaiting and
publications, nine books or book chapters and have
as part of the Canadian Digestive Diseases Week
undergoing transplantation, those with inflammatory
received well over $10 million of grant funding for
(CDDW), Montreal, 2008.
bowel disease and more; ambulatory clinics (including
projects spanning the next five years.
home TPN, dysphasia, general GI, IBD, hepatology,
Guttman O: CASL/Schering-Plough Canada
transplantation and nutrition); and evidence-based
HONOURS AND AWARDS
educational rounds and training in ethics and
Benchimol E: Canadian Child Health Clinician-Scientist
communication. Our research spans the spectrum from
Program Doctoral Award, 2008.
Hussey S: The CAG/CIHR/CCFC Fellowship, 2008-2010.
as inflammatory bowel disease, pancreatic diseases,
Benchimol E: The Hospital for Sick Children Clinician-
Hussey S: The Chisholm Memorial Fellowship, 2008.
ulcer disease, liver diseases, GI microbiology and
Scientist Training Program Research Fellowship, 2007.
Hepatology Fellowship, 2007.
basic and translational to patient-based in such areas
immunology, nutritional metabolism and nutrient
Hussey S: The Elizabeth Arbuthnot Dyson
requirements. Many of our trainees in the research
Benchimol E: Joseph M. West Family Memorial Fund,
Fellowship, 2008.
program (two years) combine a formal degree-granting
Department of Post-Graduate Medical Education,
program at the University of Toronto (M.Sc. or PhD)
University of Toronto, 2007.
Hussey S: The Miriam Neveren Memorial Award, 2008.
our fellows have gone on to very successful careers in
Benchimol E: American College of Gastroenterology
Hussey S: The Edward Christie Stevens Fellowship, 2008.
academic paediatric gastroenterology.
Clinical Research Award, 2007.
within their research fellowship years. The majority of
SUBSPECIALTY RESIDENTS
Dr. Kesete Bezu
ADMINISTRATIVE STAFF
Chona Callejo
Roxanne Francis
Margaret Johnson
Sherry Joy
Nnenna Ngoka
Lilatool Shakur
Suzanne Shek
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 63
Ling SC: Paediatric Transplant Bursary Award,
Wine E: Canadian Institute of Health Research/
Barr R, Atkinson S, Pencharz P, Arguelles GR: Nutrition
Canadian Transplant Society. Paediatric liver
Canadian Association of Gastroenterology/Industry
and cancer in children. Pediatric Blood and Cancer
transplantation: 20-year experience at The Hospital
(Astra Zeneca) Research Initiative Award, 2007.
2008: 50(S2): p 437.
for Sick Children. Canadian Society of Transplantation
PUBLICATIONS
Barron MA, Pencharz PB: Nutritional issues in infants
Adu-Afarwuah S, Lartey A, Brown KH, Zlotkin S,
with cancer. Pediatric Blood and Cancer 2007:
Pencharz P: Fellow of the American Society
Briend A, Dewey KG: Randomized comparison of
49(S7): pp 1093-1096.
for Nutrition, 2008.
three types of micronutrient supplements for home
Annual Meeting, Mont-Tremblant, Quebec, 2008.
fortification of complementary foods in Ghana:
Beck P, Shaffer E, Gall D, Sherman PM: The natural
Sherman P: Canada Research Chair, Tier 1
effects on growth and motor development. American
history and significance of ultrasonographically
(renewal), 2008.
Journal of Clinical Nutrition 2007: 86: pp 412-420.
defined polypoid lesions of the gallbladder in children.
Journal of Pediatric Surgery 2007: 42: pp 1907-1912.
Sherman P: Canadian Association of Gastroenterology
Adu-Afarwuah S, Lartey A, Brown KH, Zlotkin S,
Briend A, Dewey KG: Home fortification of
Bellissimo N, Desantadina V, Pencharz PB, Berall GB,
complementary foods with micronutrient supplements
Thomas SG, Anderson GH: A comparison of short-term
Wine E: Canadian Child Health Clinician Scientist
is well accepted and has positive effects on infant
appetite and energy intakes in weight and obese boys
Program (CCHCSP) Career Enhancement Program
iron status in Ghana. American Journal of Clinical
following glucose and protein drinks. International
Award, 2007.
Nutrition 2008: 87: pp 929-938.
Journal of Obesity 2008: 32: pp 362-336.
Visiting Professor Award, 2008.
Wine E: The Hospital for Sick Children Clinician
Ball RO, Urschel KL, Pencharz PB: Nutritional
Bellissimo N, Pencharz PB, Berall GB, Goode RC,
Scientist Training Program (CSTP), 2007.
consequences of interspecies differences in arginine
Thomas SG, Anderson GH: Effect of television viewing
and lysine metabolism. Journal of Nutrition 2007: 137:
at mealtime on food intake after a glucose preload
pp 1626S-1641S.
in boys. Pediatric Research 2007: 61: pp 745-749.
Wine E: The University of Toronto Faculty of Medicine,
Postgraduate Award (Javenthey Soobiah, Charles
Fell Charitable Trust, Chisholm Memorial Fellowship
Joseph M. West Family Memorial Fund), 2007.
64 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Bellissimo N, Pencharz PB, Berall GB, Goode RC,
Castellani C, Cuppens H, Macek Jr M, Cassiman JJ,
Draper H, Diamond IR, Temple M, John P, Ng VL,
Thomas SG, Anderson GH: Reproducibility of short-
Kerem E, Durie P, Tullis E, Assael BM, Bombieri C,
Fecteau A: Multimodal management of endangering
term food intake and subjective appetite scores after
Brown A, Casals T, Claustress M, Cutting GR,
hepatic hemangioma impact on transplant avoidance.
a glucose preload, ventilation threshold and body
Dequeker E, Dodge J, Doull I, Farrell P, Ferec C,
Journal of Pediatric Surgery 2008: 43: pp 120-126.
composition in boys. Applied Physiolology and
Girodon E, Johannesson M, Kerem B, Knowles M,
Nutrition Metabolism 2008: 33: pp 326-337.
Munck A, Pignatti PF, Radojkovic D, Rizzotti P, Schwarz
Elango R, Ball RO, Pencharz PB: Indicator amino
M, Stuhrmann M, Tzetis M, Zielenski J, Elborn JS:
acid oxidation: concept and application. Journal
Benchimol E, Kirsch R, Viero S, Griffiths AM:
Consensus on the use and interpretation of cystic
of Nutrition 2008: 138: pp 243-246.
Collagenous colitis and eosinophilic gastritis in a
fibrosis mutation analysis in clinical practice. Journal
four-year old girl: a case report and review of the
of Cystic Fibrosis 2008: 7: pp 179-196.
Elango R, Ball RO, Pencharz PB: Individual amino acid
requirements in humans: an update. Current Opinion
literature. Acta Paediatrica 2007: 96: pp 1365-1367.
in Nutrition and Metabolic Care 2008: 11: pp 34-39.
Dassopoulos T, Nguyen GC, Sitton A, Bromfiled GP,
Benchimol EI, Seow CH, Steinhart AH, Griffiths AM:
Schumm LP, Wu Y, Riguiero M, Siemanowski B,
Traditional corticosteroids for induction of remission
Griffiths AM, Brant S, Rious JD, Yang H, Duerr RH,
Elango R, Humayun MA, Ball RO, Pencharz PB: Lysine
in Crohn’s disease. Cochrane Database System
Silverberg M, Cho JH, Steinhart H: Assessment of
requirement of healthy school-age children determined
Review 2008: 2: CD006792.
reliability and validity of IBD phenotyping within the
by indicator amino acid oxidation method. American
NIDDK IBD genetics consortium (IBDGC).
Journal of Clinical Nutrition 2007: 86: pp 360-365.
Benchimol EI, Turner D, Mann EH, Thomas KE,
Inflammatory Bowel Diseases 2007: 13: pp 975-983.
Gao Y, Sherman PM, Sun Y, Li D: Multiplexed
Gomes T, McLernon RA, Griffiths AM: Toxic megacolon
in children with inflammatory bowel disease: clinical
Dorfman R, Sandford A, Taylor C, Huang B,
high-throughput electrokinetically-controlled
and radiographic characteristics. American Journal of
Frangolias D, Wang Y, Sang R, Pereira L, Sun L,
immunoassay for the detection of specific bacterial
Berthiaume Y, Tsui L-C, ParГ© PD, Durie P, Corey M,
antibodies in human serum. Analytica Chimica Acta
Zielenski J: Complex two-gene modulation of lung
2008: 606: pp 98-107.
Gastroenterology 2008: May 26 [Epub ahead of print].
disease severity in children with cystic fibrosis. Journal
of Clinical Investigation 2008: 118: pp 1040-1049.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 65
Gareau M, Jury J, MacQueen G, Sherman PM,
Humayun MA, Elango R, Moehn S, Ball RO,
Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH,
Perdue M: Probiotic treatment of rat pups normalizes
Pencharz PB: Application of the indicator amino acid
Rioux RD, Brant SR, Silverberg MS, Taylor KD,
corticosterone release and ameliorates colonic
oxidation technique for the determination of metabolic
Barmada MM, Bitton A, Dassopoulos T, Datta LW,
dysfunction induced by maternal separation. Gut
availability of sulphur amino acids from casein versus
Green T, Griffiths AM, Kistner EO, Murtha MT,
2007: 56: pp1522-1528.
soy protein isolate in adult men. Journal of Nutrition
Regueiro MD, Rotter JI, Schumm LP, Steinhart AH,
2007: 137: pp 1874-1879.
Targan SR, Xavier R, the NIDDK IBD Genetics
Consortium, Libioulle C, Sandor C, Lathrop M,
Green GJ, Weitzman SS, Pencharz PB: Resting energy
expenditure in children with stage IV neuroblastoma.
Hussey S, Terebiznik MR, Jones NL: Autophagy: healthy
Belaiche J, Dewit O, Gut I, Heath S, Laukens D,
Pediatric Research 2008: 63: pp 332-336.
eating and self digestion for gastroenterologists.
Mni M, Rutgeerts P, Van Gossum A, Zelenika D,
Heuschkel R, Salvestrini C, Beatties RM, Hildebrand H,
Journal of Pediatric Gastroenterology, Hepatology,
Franchimont D, Hugot JP, de Vos M, Vermeire S,
Nutrition 2008: 46: pp 496-506.
Louis E, the Wellcome Trust Case Control Consortium,
Cardon LR, Anderson CA, Drummond H, Nimmo E,
Walters T, Griffiths AM: Guidelines for the
management of growth failure in childhood
Ip H, Hyder Z, Haseen F, Rahman M, Zlotkin S:
Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Ghori J,
inflammatory bowel disease. Inflammatory Bowel
Improved adherence and anemia cure rates with
Bumpstead S, Gwillam R, Tremelling M, Deloukas P,
Diseases 2008: 14: 839-849.
flexible administration of micronutrient Sprinkles:
Mansfield J, Jewell D, Satsangi J, Mathew CG,
a new public health approach to anaemia control.
Parkes M, Georges M, Daly MJ. Genome-wide
Humayun MA, Elango R, Ball RO, Pencharz PB: A
European Journal of Clinical Nutrition 2007:
association defines more than 30 distinct
re-evaluation of protein requirement in young men using
September 26 [Epub ahead of print].
susceptibility loci for Crohn’s disease. Nature
the indicator amino acid oxidation technique. American
Journal of Clinical Nutrition 2007: 86: pp 995-1002.
66 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Genetics 2008: June 29 [online publication].
Johnson-Henry K, Donato K, Gordanpour M,
Lenoir-Wijnkoop I, Sanders M, Cabana M, Caglar E,
Mager D, Marcon M, Wales P, Pencharz PB: Use
Sherman PM: Lactobacillus rhamnosus strain GG
Corthier G, Rayes N, Sherman PM, Timmerman H,
of N-acetyl cysteine for the treatment of parenteral
prevents enterohemorrhagic Escherichia coli-induced
Vaneechoutte M, Van Loo J, Wolvers D: Probiotic
nutrition (PN) induced liver disease in children on
changes in epithelial barrier function. Infection and
and prebiotic influence beyond the intestinal tract.
home PN. Journal of Pediatric Gastroenterology
Immunity 2008: 76: pp 1340-1348.
Nutrition Reviews 2007: 65: pp 469-489.
and Nutrition 2008: 46: pp 220-223.
Moehn S, Bertolo RFP, Martinazzo-Dallagnol E,
Kappelman M, Bousvaros A, Hyams J, Markowitz J,
Lewis K, Caldwell J, Phan V, Prescott D, Nazli A,
Griffiths AM and the Pediatric IBD Registry Group:
Wang A, Soderholm J, Perdue M, Sherman PM,
Pencharz PB, Ball RO: Metabolic availability of lysine
Variation in the initial management of children with
McKay D: Decreased epithelial barrier function evoked
in feedstuffs determined using oral isotope delivery.
Crohn’s disease. Inflammatory Bowel Diseases 2007:
by exposure to metabolic stress and non-pathogenic E.
Livestock Science 2007: 109: pp 24-26.
13: pp 890-895.
coli is enhanced by TNFО±. American Journal of
Physiology 2008: 294: pp G669-G678.
Muise AM, Walters TD, Wine E, Griffiths AM, Turner D,
Griffiths AM, Bousvaros A, Hyams J: Body mass index
Ling SC: Congenital cholestasis syndromes: what
Silverberg MS, Rotin D: Protein tyrosine phosphatase
in children with newly diagnosed inflammatory bowel
happens when children grow up? Canadian Journal
sigma is associated with ulcerative colitis. Current
disease: observations from two multicentre North
of Gastroenterology 2007: 21: pp 743-751.
Biology 2007: 17: 1212-1218.
Madore A-M, Prevost C, Dorfman R, Taylor C, Durie P,
Nasr A, Avitzur Y, Ng VL, De Silva N, Wales PW: The
Duerr RH, Regueiro MD, Ngan BY, Xu W, Sherman PM,
Kugathasan S, Nebel J, Skelton J, Markowitz J, Keljo D,
American inception cohorts. Journal of Pediatrics
2007: 151: pp 523-527.
Zielenski J, Laprise C: Distribution of CFTR mutations
use of conjugated hyperbilirubinemia greater than 100
Leach ST, Mitchell HM, Geczy CL, Sherman PM, Day AS:
in Saguenay-Lac-Saint-Jean: proposal of a panel of
lmol/L as an indicator of irreversible liver disease in
S100 calgranulin proteins S100A8, S100A9 and
mutations for population screening. Genetics in
infants with short bowel syndrome. Journal of
S100A12 are expressed in the inflamed gastric mucosa
Medicine 2008: 10: pp 201-206.
Pediatric Surgery 2007: 42: pp 359-362.
of helicobacter pylori-infected children. Canadian
Journal of Gastroenterology 2008: 22: pp 461-464.
Ng VL, Anand R, Martz K, Fecteau A: Liver
retransplantation in children: SPLIT database analysis
of outcome and predictive factors for survival. American
Journal of Transplantation 2008: 8: pp 386-395.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 67
Ng VL, Otley AR: Understanding quality of life for
Pencharz PB: Assessment of protein nutritional status.
children after liver transplantation: a work in progress.
Pediatric Blood and Cancer 2008: 50(S2): pp 445-446.
Rosh JR, Gross T, Mamula P, Griffiths AM, Hyams J:
Hepatosplenic T-cell lymphoma in adolescents and
young adults with Crohn’s disease: a cautionary tale.
Liver Transplantation 2008: 14: pp 415-417.
Puntai J, Markowitz J, Lerer T, Hyams J, Kugathasan S,
O’Shea A-M, Wilson G, Ling SC. Minassian B, Cutz E:
Griffiths AM, Otley A, Crandall W, the Pediatric IBD
Lafora-like ground glass inclusions in hepatocytes of
Collaborative Research Group: The effect of early
Inflammatory Bowel Diseases 2007: 13: pp 1024-1030.
Samonte V, Sherman PM, Taylor G, Carricato M,
paediatric patients–report of two cases. Pediatric and
immunomodulator use in moderate to severe pediatric
Fecteau A, Ling S, Ng V: Scurvy diagnosed in a
Developmental Pathology 2007: 10: pp 351-357.
Crohn disease. Inflammatory Bowel Diseases 2008:
pediatric liver transplant patient awaiting combined
February 17 [Epub ahead of print].
kidney and liver retransplantation. Pediatric
Transplantation 2008: 12: pp 363-367.
Panaccione R, Fedorak R, Aumais G, Bernard E-J,
Bernstein CN, Bitton A, Croitoru K, Dieleman LA,
Rafii M, Elango R, Courtney-Martin G, House J, Fisher L,
Enns R, Feagan BG, Franchimont D, Greenberg GR,
Pencharz PB: High-throughput and simultaneous
Griffiths AM, Marshall J, Pare P, Patel S, Penner R,
measurement of homocysteine and cysteine in
to measure resting energy expenditure in clinical
Render C, Seidman E, Steinhart AH: Review and
human plasma and urine by liquid chromatography-
practice in children. Journal of Pediatrics 2008:152:
clinical perspectives for the use of infliximab in
electrospray tandem mass spectrometry. Analytical
pp 437-439.
ulcerative colitis. Canadian Journal of
Biochemistry 2007: 371: pp 71-81.
Shakur YA, Richards H, Pencharz PB: Is it necessary
Sharieff W, Dofonsou J, Zlotkin S. Is cooking food in
Gastroenterology 2008: 22: 261-272.
Rafii M, McKenzie JM, Roberts SA, Steiner G, Ball RO,
iron pots an appropriate solution for the control of
Pencharz P: Energy balance and body composition.
Pencharz PB: The in vivo regulation of phenylalanine
anaemia in developing countries? A randomized clinical
Pediatric Blood and Cancer 2008: 50: p 468.
hydroxylation using enrichment in Apo-B 100. American
trial in Benin. Public Health Nutrition 2007: 15: pp 1-7.
Journal of Physiology 2008: 294: pp E475-E479.
Pencharz PB, Hsu JW, Ball RO: Aromatic amino acid
requirements in healthy human subjects. Journal of
Nutrition 2007: 137: pp 1576S-1578S.
68 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Urschel KL, Rafii M, Pencharz PB, Ball RO: A multi-
Shugart YY, Silverberg MS, Duerr RH, Taylor KD,
Turner D, Grossman A, Rosh J, Gilman AR,
Wang MH, Zarfas K, Schumm LP, Bromfielf G,
Kugathasan S, Baladassano R, Griffiths AM:
tracer stable isotope quantification of the effects of
Steinhart AH, Griffiths AM, Kane SV, Barmada MM,
Methotrexate following unsuccessful thiopurine
arginine intake on whole-body arginine metabolism in
Rotter JI, Mei L, Bernstein CN, Bayless TM, Langelier D,
therapy in pediatric Crohn’s disease. American Journal
neonatal piglets. American Journal of Physiology
Cohen A, Bitton A, Rioux JD, Cho JH, Brant SR:
of Gastroenterology 2007: 102: pp 2804-2812.
2007: 293: pp E811-E818.
An SNP linkage scan identifies significant Crohn’s
disease loci on chromosomes 13q13.3 and, in Jewish
Turner D, Otley AR, Mack D, Hyams J, de Bruijne J,
Wallon C, Yang PC, Keita A, Ericson AC, McKay DM,
families, on 1p35.2 and 3q29. Genes and Immunity
Uusoue K, Walters TD, Zachos M, Mamula P,
Sherman PM, Perdue MH, Soderholm JD: Corticotropin-
2008: 9: pp 161-167.
Beaton DE, Steinhart AH, Griffiths AM: Development,
releasing hormone (CRH) regulates macromolecular
validation, and evaluation of pediatric ulcerative
permeability via mast cells in normal human colonic
Toiviainen-Salo S, Raade M, Durie PR, Ip W, Marttinen E,
colitis activity index: a prospective multicentre study.
biopsies in vitro. Gut 2008: 57: pp 50-58.
Savilahti E, Makitie O: MRI findings of the pancreas in
Gastroenterology 2007: 133(2): pp 423-432.
Ward LM, Gaboury I, Ladhani M, Zlotkin S: Vitamin
patients with Shwachman-Diamond syndrome and
mutations in the SBDS gene. Journal of Pediatrics
Turner D, Steinhart AH, Griffiths AM: Omega-3 fatty
D-deficiency rickets among children in Canada. Canadian
2008: 152: pp 434-436.
acids (fish oil) for maintenance of remission in
Medical Association Journal 2007: 177: pp 161-166.
ulcerative colitis. Cochrane Database System
Turner D, Griffiths AM: Esophageal, gastric and
Wilschanski M, Durie PR: Patterns of GI disease in
Review 2007: CD006443.
adulthood associated with mutations in the CFTR
duodenal manifestations of IBD, and the role of upper
endoscopy in IBD diagnosis. Current Gastroenterology
Turner D, Walsh CM, Benchimol EI, Mann EH,
Reports 2007: 9: pp 475-478.
Thomas KE, Chow C, McLernon RA, Walters TD,
gene. Gut 2007: 56: pp 1153-1163.
Steinhart AH, Griffiths AM: Severe paediatric ulcerative
Zlotkin S: Editorial - �Control of Anemia: the time to act
colitis: incidence, outcomes, and optimal timing for
is now’. Indian Pediatrics 2007: 44: pp 84-86.
second line therapy. Gut 2008: 57: pp 331-338.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 69
BOOKS AND BOOK CHAPTERS
Wallace J, Sherman PM: Resolution of mucosal
A multi-disciplinary human study on the genetic,
Anemia Review Panel: anaemia Guidelines for Family
inflammation. In: Progress in Inflammation Research
environmental and microbial interactions that cause
Medicine, 2nd Edition. MUMS Guideline Clearinghouse,
Series: Resolution of Inflammation (Rossi A,
IBD. Croitoru K, Griffiths AM, Ropelski M, Moyeddi P.
Toronto, 2008.
Sawatsky D, eds.) Berkhauser Verlag AG, Basel, 2007.
Crohn’s and Colitis Foundation of Canada
($5,600,000 2007-2012)
Durie PR: Schwachman-Diamond Syndrome. In:
Walters TR, Griffiths AM: Growth impairment in IBD.
Pediatric Gastrointestinal Disease, 5th Edition,
In: Pediatric Inflammatory Bowel Disease (Baldassano
A novel candidate susceptibility gene at the IBD6
Volume 2 (Kleinman RE, Sanderson IR, Goulet O,
R, Mamula P, Markowitz J, eds.). Springer, USA, 2008.
locus. Griffiths AM, Rotin D. Crohn’s and Colitis
Foundation of Canada New Innovations Grant
Sherman PM, Mieli-Vergani G, Shneider BL, eds.).
BC Decker Inc., Hamilton, 2008.
Wine E, Terebiznik M, Jones NL: Microbial interactions
($50,000 2007)
with gut epithelium. In: Paediatric Gastrointestinal
Disease, 5th Edition, Volume 1 (Kleinman R, Goulet O,
A prospective study of linear growth in paediatric
in inflammatory bowel disease. In: Pediatric
Mieli-Vergnani G, Sherman P, Schneider B, eds.).
IBD. Denson LA, Griffiths AM. Crohn’s and Colitis
Nutrition in Practice (Berthold K, ed.) Karger,
BC Decker Inc., Hamilton, 2008.
Griffiths AM, Carricato M: Enteral nutrition
Basel, Switzerland, 2008.
Foundation of America ($150,000 per year 20072010)
FUNDING
Griffiths AM, Hugot J-P: Crohn’s disease. In: Paediatric
A multicentre study of the safety and efficacy of
Adalimumab in pediatric Crohn’s disease: a multicentre
Gastrointestinal Disease, 5th Edition, Volume 1
N-acetylcysteine in the treatment of acute liver failure
study. Griffiths AM. Abbott Laboratories (per patient
(Kleinman R, Goulet O, Mieli-Vergnani G, Sherman P,
in paediatric patients not caused by acetaminophen.
remuneration; anticipated $90,000 2007-2009)
Schneider B, eds.). BC Decker Inc., Hamilton, 2008.
Ng VL, Fecteau A. National Institutes of Health/
National Institute of Diabetes and Digestive and
Kidney Diseases (US$69,000 2005-2010)
70 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Arginine and CF. Grasemann H, Ratjen F,
Development and validation of a disease-specific
Epidemiology of eosinophilic esophagitis in children
Pencharz P. Canadian Cystic Fibrosis Foundation
health-related quality of life questionnaire for children
and adolescents in Canada. Marcon MA, Dourin E.
($140,000 2007-2010)
after liver transplantation. Otley AR, Ng VL, Nicholas
Directing study which involves all 16 paediatric
Assessment of activity and prediction of outcome in
DB, Thompson J, Gilmour S, Watters C. Canadian
centres in Canada. J. Campbell Fund ($62,966
Institutes of Health Research ($280,576 2005-2009)
2006-2008)
paediatric ulcerative colitis. Turner D, Steinhart H,
Griffiths AM. Canadian Association of
Development and validation of an objective skill
Evaluation of a novel parenteral lipid source in the
Gastroenterology/Canadian Institutes of Health
assessment for colonoscopy. Ling SC, Walsh C.
prevention of PN associated cholestasis. Wales P,
Research ($65,000 per year 2006-2008)
The Hospital for Sick Children Paediatric
Pencharz P. Fresenius-Kabi ($159,850 2008)
Consultants Partnership ($4,968 2007)
Evaluation of CFTR function ex-vivo in sweat glands
Cell signals: cell signalling in mucosal inflammation
of perfused skin as a translational tool for future drug
and pain. Ellen R, Jones NL. Canadian Institutes
Development of a new sweat test using sweat
of Health Research ($300,000 2002-2008)
potential measurements. Durie PR. Cystic Fibrosis
trials in CF. Durie PR, Pang C, Bear CE, Gonska T.
Foundation Therapeutics, Inc. ($70,818 US 2008)
(SickKids) Research Institute, New Ideas Grant
($50,000 2008-2009)
Clinical Research Facilitation Award. Durie PR. Cystic
Fibrosis Foundation Therapeutics, Inc.
Development of a piglet short gut model. Turner J,
(US$108,280 2007-2008)
Ball R, Pencharz P, Wales P. Stollery Children’s
Food intake control in children. Anderson GH,
Hospital Foundation ($29,223 2007)
Berall GB, Goode RC, Pencharz PB. Canadian
Institutes of Health Research ($104,219 2007-2010)
Clinician scientist training program in clinical nutrition
research. Pencharz P. Canadian Institutes of Health
Diagnosing cystic fibrosis in neonates and adults:
Research ($265,000 2002-2008)
where do we draw the line? Durie PR, Tullis E,
Ratjen F. Canadian Cystic Fibrosis Foundation
transplantation. Ng VL, Fecteau A. National Institutes
Determining the threshold of CFTR function that
($120,000 per year 2008-2011)
of Health/National Institute of Diabetes and
causes CF disease. Durie PR. Canadian Cystic
Functional outcomes after paediatric liver
Digestive and Kidney Diseases (US$6,000 2007-2008)
Fibrosis Foundation ($110,000 per year 2005-2008)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 71
Genetic predictors of time to recurrence following ileal
Innovative strategies for optimizing management
North American IBD Genetics Consortium. Cho J,
resection in early onset Crohn’s disease. McLeod R,
of infants with biliary atresia. Guttman O
Duerr R, Silverberg M, Griffiths AM, Rotter J,
Griffiths AM. Crohn’s and Colitis Foundation
(co-supervisors: Ng VL, Roberts EA.) Canadian
Brandt S, Rioux J. National Institutes of Health
of Canada ($150,000 per year 2007-2010)
Association for the Study of Liver Disease/
($3,000,000 2007-2011)
Canadian Institutes of Health Research
Host responses to Helicobacter pylori infection:
Fellowship Award ($55,000 2007-2008)
Opportunity fund: funding for infrastructure associated
with a Canada Research Chair. Sherman PM. Canada
role of STAT3 during H. pylori infection. Jones NL.
Canadian Institutes of Health Research
International Collaboration Project. Zlotkin S.
Foundation for Innovation, Leaders ($427,348 total
($100,000 2007-2008)
Canadian Institutes of Health Research
[$170,939 direct from CFI] 2008)
($25,000 2007-2008)
Outcomes in severe paediatric ulcerative colitis:
Immune regulation and biomarker development in
paediatric and adult onset human autoimmune
Investigation of Helicobater pylori survival in host cells.
a multicentre study. Griffiths AM. Schering Canada
diseases. Bar-Or A, Banwell B, Piccirillo CA,
Jones NL. Early Researcher Award, Ontario Ministry
($350,000 2007-2009)
Polychronakos C, Sherman PM. Canadian Institutes of
of Research and Innovation ($150,000 2006-2011)
Pico-salax versus poly-ethylene glycol for bowel
Health Research Team Grant ($2,018,445 2007-2112)
Knowledge translation award. Zlotkin S. Canadian
Induction of autophagy by H. pylori. Jones NL.
Institutes of Health Research ($100,000 2006-2007)
cleanout before colonoscopy in children: a single
blinded randomized controlled trial. Ling SC, Griffiths AM,
Turner D. Ferring Inc. ($24,000 2006-2008)
Canadian Association of Gastroenterology/
Canadian Institutes of Health Research/Abbott
Molecular genetics, SBDS function and deficiency in
($45,000 2007-2009)
SDS. Rommens JM, Durie PR. National Institutes of
Protocol AI463-08: evaluation of the
Health ($1,250,000 2004-2009)
pharmacokinetics, safety, tolerability and efficacy
of entecavir (ETV) in paediatric subjects with chronic
Infliximab in paediatric ulcerative colitis: a multicentre
study. Griffiths AM. Centocor (per patient
Neonatal protein and energy metabolism. Pencharz P.
hepatitis B virus (HBV) infection who are HBeAg-
remuneration; anticipated $100,000 2007-2009)
Medical Research Council/Canadian Institutes of
positive. Ling SC. Bristol-Myers Squibb
Health Research ($136,817 2006-2011)
($25,000 per patient, 2007-2013)
72 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Role of autophagy in Helicobacter pylori infection
Studies of paediatric liver transplantation (SPLIT).
The contribution of genetic modulators of disease
and disease. Jones NL. Canadian Institutes of Health
Ng V, Fecteau A. National Institutes of Health/
severity in cystic fibrosis to other diseases with
Research ($103,959 per year 2008-2013)
National Institute of Diabetes and Digestive and
similarities of clinical phenotype. Durie PR, Zielenski J.
Kidney Diseases (US$75,000 2005-2010)
Genome Canada ($5,787,662 2005-2009)
inflammatory bowel disease. Sherman PM. Crohn’s
Studies of primary sclerosing cholangitis (STOPSC).
The use of indicator amino acid oxidation to determine
and Colitis Foundation of Canada Fay Shapiro Cutler
Ling SC, Durie P, Griffiths AM. Musette and Allen
amino acid requirement. Pencharz P, Ball R. Medical
Grant-In-Aid of Research ($375,000 2007-2010)
Morgan Jr. Foundation (annual and patient-based
Research Council/Canadian Institutes of Health
stipends, $10,000 per year plus $200 per patient
Research ($152,967 2005-2010)
Role of probiotics in the management of experimental
Salary award: Tier 1 (renewal). Sherman PM.
2006-2009)
Training grant: cell signalling in mucosal inflammation
Canada Research Chair ($1,400,000 2008-2015)
Targeted small molecule therapies for cystic
and pain. Ellen R, Sherman PM. Canadian Institutes
SBDS protein expression in peripheral blood
fibrosis. Bear CE, Deber CM, Durie PR, Lingwood C,
for Health Research ($300,000 per year 2002-2008)
leukocytes. Durie PR, Rommens JM, Shimamura A.
Rotin D, Ratjen F, Yeger H. Canadian Cystic
Shwachman Diamond Syndrome Foundation
Fibrosis Foundation - BREATHE Program
(US$30,000 per year 2006-2008)
($480,000 per year 2004-2009)
Upper limits of leucine requirements. Pencharz P.
International Council for Amino Acid Science
($155,850 2008)
Short bowel syndrome, neonatal piglet model. Turner J,
Team in childhood obesity research. McCrindle B,
Ball R, Pencharz P, Wales P. SickKids Foundation
Anderson GH, Hamilton J, Parkin P, Pencharz P.
($62,690 2008-2009)
Canadian Institutes of Health Research
placebo controlled study of VX770 in patients with
($506,842 2008; $464,474 2008-2011)
cystic fibrosis having G551D mutations to evaluate
VX06-770-101: a Phase 2a, randomized, double-blind,
Sprinkles project support. Zlotkin S. HJ Heinz
safety, phamacokinetics and biomarkers of CFTR
Company Foundation ($600,000 2006-2007)
activity. Durie PR (Toronto site). Vertex Pharmaceuticals,
Inc. (US$30,000 per year 2007-2008)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 73
Dr. Angela Punnett
DIVISION HEAD
Dr. Victor Blanchette
FULL-TIME
Dr. Oussama Abla
Dr. Sarah Alexander
Dr. Ute Bartels
Dr. Sylvain Baruchel
Dr. Eric Bouffet
Dr. Leonardo BrandГЈo
Dr. Manuel Carcao
Dr. Helen Chan
Dr. John Doyle
Dr. Yigal Dror
Dr. Adam Gassas
Dr. Ron Grant
Dr. Abha Gupta
Dr. Hans Hitzler
Dr. Annie Huang
Dr. Meredith Irwin
Dr. Walter Kahr
Dr. Melanie Kirby
Dr. David Malkin
Dr. Ahmed Naqvi
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Paul Nathan
Isaac Odame
Angela Punnett
Lillian Sung
Uri Tabori
Sheila Weitzman
Suzan Williams
CROSS-APPOINTEES/
PART-TIME
Dr. Anthony Chan
Dr. Stephen Comay
Dr. Lee Ann Gallant
Dr. Mark Greenberg
Dr. David Hodgson
Dr. Nicole Inch
Dr.
Dr.
Dr.
Dr.
Dr.
Normand Laperriere
Barbara-Ann Millar
Aubrey Maze
Ben Saxon
Jill Solomon
Division of Haematology/Oncology
OVERVIEW
program (Program Co-Heads, Drs. David Malkin and
cancer genetics, blood and marrow transplantation
The Division of Haematology/Oncology provides a
Rosanna Weksberg). The haematology section has
and paediatric thrombosis and haemostasis.
diagnostic service and specialist care for children
large programs in paediatric thrombosis and
<18 years of age with cancer (paediatric oncology),
haemostasis, the paediatric haemoglobinopathies and
Research in the division spans clinical to basic
non-malignant blood disorders (paediatric haematology)
the paediatric marrow failure syndromes. The division
science with a special focus on translational research.
and hematopoietic stem cell (blood and marrow)
is an active member of the Children’s Oncology Group
Currently, 13 of the division’s 27 full-time faculty have
transplantation. The division is the largest of its kind
(COG), the largest paediatric clinical trials group in
appointments as clinician-scientists or clinician-
in Canada and among the largest of such programs
North America (SickKids Principal Investigator, Dr. Ron
investigators in the Department of Paediatrics with
worldwide. Approximately 300 new cancer cases are
Grant), and is committed to the improvement in
parallel appointments in the Research Institute.
registered in the oncology program each year, and The
outcomes of children with cancer through participation
Research in the division is multidisciplinary, involving
Hospital for Sick Children (SickKids) is the designated
in ethics approved, prospective clinical trials. The
health care professionals with expertise in a variety of
site for haematopoietic stem cell transplantation for
division is a member of the paediatric oncology phase I
areas (e.g., nursing, pharmacy, psychology, social
patients < 18 years of age in the Province of Ontario.
Consortium of COG (Principal Investigator, Dr. Sylvain
work). The division is committed to facilitating
Baruchel), and is an active participant in activities of
knowledge exchange through international
Reflecting the size and diversity of its clinical services,
the Société Internationale d’Oncologie Pédiatrique
partnerships with a particular focus on countries
the division is functionally organized into six sections
(SIOP), the Histiocyte Society and the Berlin Frankfurt
lacking the health care resources available in Canada.
and three programs: the leukemia/lymphoma section
Munster (BFM) paediatric leukemia clinical trials group.
A major development over the past year was the
(Section Head, Dr. Sheila Weitzman); the
approval of the Comprehensive Cancer Centre at
neurooncology (brain tumor) section (Section Head, Dr.
The division is the largest Royal College of Physicians
Eric Bouffet); the solid tumor section (Section Head,
and Surgeons of Canada accredited training program
SickKids. The Centre will serve as the “hub” linking
Dr. Ron Grant); the blood and marrow transplantation
for the specialty paediatric haematology/oncology in
clinicians and researchers working in the field of
section (Section Head, Dr. John Doyle); the
Canada (Training Program Director, Dr. Angela
cancer at SickKids with the goal of establishing
haematology section (Section Head, Dr. Victor
Punnett). The education program in the division also
SickKids as an international leader in the field of
Blanchette); the inpatient services section (Section
includes a very large international training program in
pediatric cancer research, education and clinical care.
The Executive of the Comprehensive Cancer Centre
Head, Dr. Sarah Alexander); the long-term follow up
paediatric haematology/oncology and offers
program (Program Head, Dr. Mark Greenberg); the new
subspecialty training opportunities in areas such as
includes Dr. David Malkin, Dr. David Kaplan, Dr. James
agents and experimental therapies program (Program
paediatric leukemia/ lymphoma, neurooncology,
Rutka, Judy Van Clieaf and Dr. Victor Blanchette.
Dr. A. Lee Chong
Dr. C. Macartney
Dr. A. Muhammad
Dr. J. Robertson
Dr. M. Rojas
Dr. K. Scheinemann
Dr. C. Segbefia
Dr. P. Sivaprakasam
ADMINISTRATIVE STAFF
Bibi Ali
Ingrid Argiropoulos
Barbara Black
Sandra Carbone-Walker
Connie Grillo
Lucy Holford
Head, Dr. Sylvain Baruchel); and the cancer genetics
CLINICAL AND
RESEARCH FELLOWS
Dr. I. Abosoudah
Dr. F. Al-Abbas
Dr. S. Al-Afghani
Dr. T. Al-Asaad
Dr. R. Al-Mahmoud
Dr. O. Al-Sharif
Dr. Q. Alharbi
Dr. P. Angelini
Dr. L. Avila
Dr. J. Baker
Dr. V. Breakey
Dr. M. Cada
Dr. P. Gibson
Dr. C. Lam
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
O. Teuffel
T. Truong
M. Van Den Akker
B. Williams
P. Wong
P. Yenson
Shanaz Karim
Philippa McCaffrey
Christal Malcolm
Sylvia Muir
Annabel Sousa
Laurel Willmott
Arlene Zaldivar
The administrative team for the division includes Dr.
Sung L: University of Toronto Junior
Victor Blanchette (Division Head), Dr. Sheila Weitzman
Researcher Award, 2008.
Alexander SW, Hopewell S, Hunter S, Chouksey A:
Rituximab and desensitization for a patient with
severe factor IX deficiency, inhibitors and history of
(Associate Director, Clinical), Judy Van Clieaf (Director,
Child Health Services) and Lucy Holford (Team Leader,
PUBLICATIONS
anaphylaxis. Journal of Paediatric Haematology
Administrative and Support Services).
Abdelhaleem M, Shago M, Beimnet K, Sayeh E,
Oncology 2008: 30: pp 93-95.
Bartakke S, Weitzman S: Childhood acute myeloid
HONOURS AND AWARDS
leukaemia with hemophagocytosis by the blasts and
Alkalbani N, Weitzman S, Abdelhaleem M, Carcao M,
Blanchette V: Dr. Richard Rowe Award for Clinical
inv(8)(p11q13) with MOZ-TIF2 fusion transcripts.
Abla O: Acute lymphoblastic leukaemia presenting
Excellence, Department of Paediatrics, 2008.
Journal of Pediatric Haematology and Oncology 2007:
with gross hematuria. Paediatrics and Child Health
29: pp 643-645.
2007: 12: pp 573-574.
Abdelhaleem M, Shago M, Sayeh E, Abla O:
Almanjomi F, Armstrong D, Abla O, Naqvi A, Weitzman S,
Greenberg M: O. Harold Warwick Prize, 2007.
Hitzler H: Alvin Zipursky Teaching Award, Division of
Childhood myeloid/natural killer precursor acute
Hitzler J: Lumbar spinal fluid collections in children
Haematology/Oncology, The Hospital for Sick Children.
leukaemia with der(5) t(4;5)(q31;q31.3) and t(14;17)
treated with intrathecal chemotherapy: elevated CSF
2008.
(q32;q23). Cancer Genetics and Cytogenetics 2007:
protein as a diagnostic clue. Pediatric Blood and
178: pp 141-143.
Cancer 2008: 5: pp 295-298.
Abdullah S, Diezi M, Sung L, Dupuis L, Geary D,
Attias D, Weitzman S: The efficacy of rituximab in
Irwin M: MDM2 International Workshop Young
Investigator Award, 2007.
Abla O: Sevelamer hydrochloride: a novel treatment
high-grade pediatric B-cell lymphoma/leukaemia:
Irwin M: American Society of Pediatric Haematology
of hyper-phosphatemia associated with tumor lysis
a review of available evidence. Current Opinion in
Oncology Young Investigator Award, 2007.
syndrome in children. Pediatric Blood and Cancer
Pediatrics 2008: 20: pp 17-22.
2008: 51: pp 59-61.
Ayi K, Min-Oo G, Serghides L, Crockett M, Kirby-Allen M,
Irwin M: Elsie Winifred Crann Memorial Trust
Quirt I, Gros P, and Kain KC: Pyruvate kinase
Award for Research in Life Sciences, University
Abla O, Dror Y, Shago M: Translocation (X:10) in a
of Toronto, 2007.
child with therapy-related acute myeloid leukaemia
deficiency protects and malaria. New England
following chemotherapy for Ewing’s sarcoma. Cancer
Journal of Medicine 2008 358: pp 1805-1810.
Malkin D: Man of Distinction Honoree,
Genetics and Cytogenetics 2007: 178: pp 168-169.
Israel Cancer Research Fund, 2008.
76 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Baker JM, Viero S, Kim PC, Grant RM: Stage III cystic
Bouffet E, Tabori U, Bartels U: Paediatric
Diaz RJ, Laughlin S, Nicolin G, Buncic JR, Bouffet E,
partially differentiated nephroblastoma recurring after
ependymomas: should we avoid radiotherapy?
Bartels U: Assessment of chemotherapeutic response
nephrectomy and chemotherapy. Pediatric Blood and
Lancet Oncology 2007: 8: pp 665-666.
in children with proptosis due to optic nerve glioma.
Child’s Nervous System 2008: 24: pp 707-712.
Cancer 2008: 50: pp 129-31.
Bulley S, Gassas A, Dupuis LI, Aplenc R, Beyene J,
Barrette S, Bernstein ML, Robison LL, Samson Y,
Greenberg ML, Doyle JJ, Sung L: Inferior outcomes for
Dupuis L, Sibbald C, Schechter T, Ansari M, Gassas A,
Theoret Y, Kassir N, Champagne MA, Doyle J:
Brossard J, Weitzman S, Woods WG: Incidence of
overweight children undergoing allogeneic stem cell
neuroblastoma after a screening program. Journal
transplantation. British Journal of Haematology 2007:
IV busulfan dose individualization in children
of Clinical Oncology 2007: 25: pp 4929-4932.
140: pp 214-217.
undergoing hematopoietic stem cell transplant:
Bartakke S, Abdelhaleem M, Abla O: Childhood
Calado RT, Graf SA, Wilkerson KL, Kajigaya S,
acute lymphoblastic leukaemia simulating multifocal
Ancliff PJ, Dror Y, Chanock SJ, Lansdorp PM,
osteomyelitis. British Journal of Haematology 2007:
Young NS: Mutations in the SBDS gene in acquired
Epstein I, Stevens S, McKeever P, Baruchel S, Jones H:
139: p 2.
aplastic anemia. Blood 2007: 110: pp 1141-1146.
Using puppetry to elicit children’s talk for research.
limited sampling strategies. Biology of Blood and
Marrow Transplantation 2008: 14: pp 576-582.
Nursing Inquiry 2008: 15: pp 49-56.
Bartakke S, Abdelhaleem M, Carcao M: Valproic acid
Castelliono RC, DeBortoli M, Skapura DG, Lin LL,
induced pure red cell aplasia and megakaryocytic
Perlaky L, Sheldon MH, Irwin MS, Kim JYH:
Feldman BM, Aledort L, Bullinger M, Delaney FM,
dysplasia. British Journal of Haematology 2008:
Medulloblastomas overexpress TAp73 and DNp73.
Doria AS, Funk S, Giangrande P, Lundin B, Manco-
141: p 133.
BMC Cancer 2007: 7: p 127.
Johnson M, Miners A, Scriba PC, Srivastava A,
Bernhard N, Morris SK, Taylor G, Oudjhane K,
Chan AK, Black L, Ing C, Brandao LR, Williams S:
haemophilia prophylaxis: governmental and insurer
Baruchel S: Massive intrathoracic tumor in a relatively
Utility of a PTT in monitoring unfractionated heparin
perspectives. Proceedings of the Second International
asymptomatic boy. Pediatric Annals 2007: pp 634-635.
in children. Thrombosis Research 2007: October 31
Prophylaxis Study Group (IPSG) Symposium, October
[Epub ahead of print].
2005, Munich, Germany. Haemophilia 2007: 13(6):
Schramm W, Blanchette VS: The economics of
pp 745-749.
Blanchette V, Bolton-Maggs P: Childhood immune
thrombocytopenic purpura: diagnosis and
Chera R, Gupta AA, Bailey D, Somers RG, Kukreti V,
management. Pediatric Clinics in North
Crump M: Small intestinal B-cell lymphoma in a
America 2008: 55: pp 393-420.
patient with lymphangiectasia secondary to abdominal
Blanchette V: Musculoskeletal measurement tools
lymphangioma. Journal of Clinical Oncology 2008: 26:
from the International Prophylaxis Study Group (IPSG).
pp 675-678.
Haemophilia 2008: 14: pp 162-169.
Feldman BM, Funk S, Lundin B, Doria AS, Ljung R,
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 77
Glade Bender JL, Adamson PC, Reid JM, Xu L,
Finkelstein Y, Schechter T, Garcia-Bournissen F, Kirby
Gassas A, Ishaqi MK, Afzal S, Finkelstein-Schechter T,
M, Nurmohamed L, Juurlink D, Blanchette V, Koren G:
Dupuis A, Doyle J: A comparison of the outcomes of
Baruchel S, Shaked Y, Kerbel RS, Cooney E, Stempak D,
Is morphine exposure associated with acute chest
children with acute myelogenous leukaemia in either
Chen HX, Krailo MD, Ingle AM, Blaney SM, Kandel JJ,
syndrome in children with vaso-occlusive crisis of
first or second complete remission (CRI vs CR2)
Yamashiro DJ: Phase I trial and pharmacokinetic study
sickle cell disease? A six-year case-crossover study.
following allogeneic hematopoietic stem cell
of bevacizumab in pediatric patients with refractory
Clinical Therapeutics 2007: 29: pp 2738-2743.
transplantation at a single transplant center. Bone
solid tumours: a children’s oncology group study.
Marrow Transplantation 2008: 41: pp 941-945.
Journal of Clinical Oncology 2008: 26: pp 399-405.
Prophylaxis for severe haemophilia: clinical challenges
Gassas A, Sung L, Saunders EF, Doyle J: Graft-
Green GJ, Weitzman SS, Pencharz PB: Resting energy
in the absence as well as in the presence of inhibitors.
versus-leukaemia effect in hematopoietic stem cell
expenditure in children newly diagnosed with stage
Haemophilia 2008: 14: pp 196-201.
transplantation for pediatric acute lymphoblastic
IV neuroblastoma. Pediatric Research 2008: 63:
leukaemia: significantly lower relapse rate in unrelated
pp 332-336.
Fischer K, Valentino L, Ljung R, Blanchette V:
Gallie BL, Zhao J, Vandezande K, White A, Chan HSL:
transplantations. Bone Marrow Transplantation 2007:
Global issues and opportunities for optimized
40: pp 951-955.
2007: 49: pp 1083-1090.
Greenberg J, Somme S, Russnes HE, Durbin AD,
Malkin D: The estrogen receptor pathway in
retinoblastoma care. Pediatric Blood and Cancer
Gerrard M, Cairo MS, Weston C, Auperin A, Pinkerton R,
rhabdomyosarcoma: a role for estrogen receptor-Гџ
Lambilliote A, Sposto R, McCarthy K, Lacombe MJ,
in proliferation and response to the antiestrogen
Gassas A, Ishaqi MK, Afzal S, Dupuis A, Doyle JJ:
Perkins SL, Patte C: FAB LMB96 International Study
4’OH-tamoxifen. Cancer Research 2008: 68:
Outcome of haematopoietic stem cell transplantation
Committee: excellent survival following two courses of
pp 3476-3485.
for paediatric acute lymphoblastic leukaemia in third
COPAD chemotherapy in children and adolescents with
complete remission: a vital role for graft-versus-host-
resected localized B-cell non-Hodgkin’s lymphoma:
Gupta A, Tyrrell P, Valani R, Benseler S, Weitzman S,
disease/graft-versus-leukaemia effect in survival.
results of the FAB/LMB 96 international study. British
Abdelhaleem M: The role of the initial bone marrow
British Journal of Haematology 2008: 140: pp 86-89.
Journal Haematology 2008: 141: pp 840-847.
aspirate in the diagnosis of hemophagocytic
lymphohistiocytosis. Pediatric Blood and Cancer
2008: 51: pp 402-404.
78 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Gupta A, Weitzman S, Abdelhaleem M: The role of
Husain M, Naqvi A, Ngan B, Aiuti A, Atkinson A,
Komvilaisak P, Grant R, Weitzman S, Brandao L,
hemophagocytosis in bone marrow aspirates in the
Grunebaum E, Roifman C: Burkitt’s lymphoma in a
Blaser S, Chait P, Connolly B, Williams S: Epidural
diagnosis of hemophagocytic lymphohistiocytosis.
patient with adenosine deaminase deficiency-severe
hematomas following tissue plasminogen activator
Pediatric Blood and Cancer 2008: 50: pp 192-194.
combined immunodeficiency treated with polyethylene
(tPA) therapy for pulmonary embolism in a pediatric
glycol-adenosine deaminase. Journal of Pediatrics
patient with stage IV Burkitt’s lymphoma: a case
2007: 151: pp 93-95.
report. Thrombosis Research 2008: 121: pp 709-712.
Irwin MS, Thiele CJ, Kaplan DR: Neuroblastoma cells
Jackson EM, Shaikh TH, Gururangan S, Jones MC,
Koo A, Sung L, Allen U, Naqvi A, Drynan-Arsenault J,
isolated from bone marrow metastases contain an
Malkin D, Nikkel SM, Zuppan CW, Wainwright LM,
Dekker A, Maloney AM, Dupuis L: Efficacy and safety
enriched tumor-initiating cell. Cancer Research 2007:
Zhang F, Biegel JA: High-density single nucleotide
of caspofungin for the empiric management of fever in
67: pp 11234-11243.
polymorphism array analysis in patients with germline
neutropenic children. Pediatric Infectious Disease
deletions of 22q11.2 and malignant rhabdoid tumor.
Journal 2007: 26: pp 854-856.
Hansford L, McKee A, Zhang L, George R, Gerstle JT,
Thorner P, Smith KM, Look AT, Yeger H, Miller FD,
Hargrave D, Chuang N, Bouffet E: Conventional MRI
Human Genetics 2007: 122: pp 117-127.
Kretschmar C, Kleinberg L, Greenberg M, Burger P,
cannot predict survival in childhood diffuse intrinsic
Holmes E, Wharam M: Pre-radiation chemotherapy
pontine glioma. Journal of Neurooncology 2008: 86:
Johnston D, Keene D, Lafay-Cousin L, Steinbok P,
pp 313-319.
Carret A, Crooks B, Strother D, Wilson B, Odame I,
with response-based radiation therapy in children with
Eisenstat D, Mpofu C, Zelcer S, Huang A, Bouffet E:
central nervous system germ cell tumors: a report
Supratentorial primitive neuroectodermal tumors: A
from the Children’s Oncology Group. Pediatric Blood
Carcao M: A comprehensive review of rFVIIa usage in
Canadian Paediatric Brain Tumor Consortium report.
and Cancer 2007: 48: pp 285-291.
a tertiary care pediatric centre. Pediatric Blood and
Journal of Neuro-oncology 2008: 86: pp 101-108.
Heller M, Lau W, Pazmino-Canizares J, Brandao LR,
Kuhne, T, Blanchette V, Buchanan GR, Ramenghi U,
Cancer 2008: 50: pp 1013-1017.
Klaassen RJ, Blanchette VS, Barnard D, Wakefield CD,
Donato H, Tamminga RY, Rischewski J, Berchtold W,
Hitzler, JK: Acute megakaryoblastic leukaemia in
Curtis C, Bradley CS, Neufeld EJ, Buchanan GR, Silva
Imbach P, on behalf of the Intercontinental Childhood
Down’s Syndrome. Pediatric Blood and Cancer 2007:
MP, Chan AK, Young NL: Validity, reliability and
ITP Study Group: Splenectomy in children with
49: pp 1066-1069.
responsiveness of a new measure of health-related
idiopathic thrombocytopenic purpura: a prospective
quality of life in children with immune
study of 134 children from the Intercontinental
thrombocytopenia purpura: The Kids’ Tools (KIT).
Childhood ITP Study Group. Pediatric Blood and
Journal of Pediatrics 2007: 150: pp 510-515.
Cancer 2007: 49: pp 829-834.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 79
Lafay-Cousin L, Bartels U, Raybaud C, Kulkarni A,
Lau LM, Stuurman K, Weitzman S: Skeletal
McDonnell C, Barlow R, Campisi P, Grant RM, Malkin D:
Guger S, Huang A, Bouffet E: Neuroradiological
Langerhans cell histiocytosis in children: permanent
Fatal peri-operative acute tumour lysis syndrome
findings of bleomycin extravasation in cystic
consequences and health-related quality of life in
precipitated by dexamethasone. Anaesthesia 2008:
craniopharyngioma. Journal of Neurosurgery 2007:
long-term survivors. Pediatric Blood and Cancer 2008:
63: pp 652-655.
pp 107: pp 318-323.
50: pp 607-612.
Metzger ML, Stewart CF, Freeman BB, Billups CA,
Hoffer FA, Wu J, Coppes MJ, Grant RM, Chintagumpala
Lafay-Cousin L, Sung L, Carret AS, Hukin J, Strother D,
Liang ML, Ma J, Ho M, Solomon L, Bouffet E, Rutka JT,
Wilson B, Zelcer S, Odama I, Silva M, Mpofu C,
Hawkins C: Tyrosine kinase expression in pediatric
M, Mullen EA, Alvarado C, Daw NC, Dome JS:
Johnson D, Bouffet E, on behalf of the Canadian
high grade astrocytoma. Journal of Neurooncology
Topotecan is active against Wilms’ tumor: a result
Paediatric Brain Tumour Consortium: Carboplatin
2008: 87: pp 247-253.
of a multi-institutional phase II study. Journal of
Clinical Oncology 2007: 25: pp 3130-3136.
hypersensitivity reaction in paediatric low grade
glioma patients: a national experience. Cancer 2008:
112: pp 892-899.
Larouche V, Huang A, Bartels U, Bouffet E: A difficult
Mabbott D, Barnes M, Laperriere N, Landry SH,
Bouffet E: Neuro-cognitive function in same-sex twins
Morel CF, Gassas A, Doyle JJ, Clarke JT:
following focal radiation for medulloblastoma. Journal
Unsuccessful treatment attempt: cord blood stem
of Neurooncology 2007: 9: pp 460-464.
cell transplantation in a patient with Niemann-Pick
disease type A. Journal of Inherited Metabolic
start: tumors of the central nervous system in the
first year of life. Pediatric Blood and Cancer 2007:
Mabbott D, Penkman L, Witol A, Strother D, Bouffet E:
49: pp 1074-1082.
Relations among core neuro-cognitive functions in
children with posterior fossa tumours.
Lau KK, Stoffman JM, Williams S, McCusker P,
Neuropsychology 2008: 22: pp 159-168.
Disease 2007: 30: p 987.
Nathan PC, Ness KK, Greenberg ML, Whitton J,
Hudson M, Mertens A, Laverdiere C, Wolden S,
Davidoff A, Robison LL, Zeltzer L, Gurney J: Quality
Brandao L, Patel S, Chan AK, Canadian paediatric
of life in survivors of childhood Wilms’ tumor or
Thrombosis and Hemostasis Network: neonatal renal
Manjomi F, Armstrong D, Abla O, Naqvi A, Weitzman S,
vein thrombosis: review of the English-language
Hitzler J: Lumbar spinal fluid collections in children
neuroblastoma: a report from the Childhood Cancer
literature between 1992 and 2006. Pediatrics 2007:
treated with intrathecal chemotherapy: elevated CSF
Survivor Study. Pediatric Blood and Cancer 2007:
120: pp e1278-e1284.
protein as a diagnostic clue. Pediatric Blood and
49: pp 704-715.
Cancer 2008: 51: pp 295-298.
Lau LM, Nugent J, Zhao X, Irwin MS: HDM2 antagonist
Nutlin-3 disrupts p73-HDM2 binding and enhances
p73 function. Oncogene 2008: 27: pp 997-1003.
80 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Rosenberg PS, Alter BP, Link DC, Stein S, Rodger E,
Nathan PC, Patel S, Dilley K, Goldsby R, Harvey J,
Punnett A, Sung L, Price V, Das P, Diezi M, Doyle J,
Jacobsen C, Kadan-Lottick N, McKinley K, Millham AK,
Dupuis LL: Achievement of target cyclosporine
Boyard AA, Aprikyan AA, Bonilla MA, Dror Y,
Moore I, Okcu MF, Woodman CL, Brouwers P,
concentrations as a predictor of severe acute GvHD
Kannourakis G, Newburger PE, Boxer LA, Dale DC:
Neutrophil elastase mutations and risk of leukemia
Armstrong FD: Guidelines for identification of,
in children undergoing haematopoietic stem cell
advocacy for, and intervention in neurocognitive
transplantation and receiving cyclosporine and
in severe congenital neutropenia. British Journal of
problems in survivors of childhood cancer. Archives
methotrexate prophylaxis. Therapeutic Drug
Haematology 2008: 140: pp 210-213.
of Pediatrics and Adolescent Medicine 2007: 161:
Monitoring 2007: 29: pp 750-757.
Rubinger M, Lillicrap D, Rivard GE, Teitel J, Carcao M,
pp 798-806.
Hensman C, Walker I, and the Association of
Qaddoumi I, Musharbash A, Elayyan M, Mansour A,
Nicholson A, Berger K, Bohn R, Carcao M, Fischer K,
Al-Hussaini M, Drake J, Swaidan M, Bartels U,
Hemophilia Clinic Directors of Canada: A prospective
Gringeri A, Hoots K, Mantovani L, Schramm W,
Bouffet E: Closing the survival gap: implementation of
surveillance study of factor VIII inhibitor development
Van Hout BA, Willan AR, Feldman BM: Recommendations
medulloblastoma protocols in a low-income country
in the Canadian haemophilia A population following
for the reporting of economic evaluations of hemophilia
through a twinning program. International Journal of
the switch to a recombinant factor VIII product
prophylaxis: a nominal group consensus statement on
Cancer 2008: 15: pp 1203-1206.
formulated with sucrose. Haemophilia 2008: 14:
pp 281-286.
behalf of the economics expert working group of the
International Prophylaxis Study Group. Haemophilia
Ramphal R, Grant RM, Dzolganovski B, Constantin J,
2008: 14: pp 127-132.
Tellier R, Allen U, Weitzman S, Matlow A, Petric M,
Rujkijyanont P, Watanabe KI, Ambekar C, Wang H,
Sung L: Herpes simplex virus in febrile neutropenic
Beyene J, Dror Y: Sbds-deficient cells undergo
Pongtanakul B, Das PK, Charpentier K, Dror Y:
children undergoing chemotherapy for cancer:
accelerated apoptosis through the Fas-pathway
Outcome of children with anaplastic anemia treated
a prospective cohort study. Pediatric Infectious
and not through the Bax/Bc12/BclXL pathway.
with immunosuppressive therapy. Pediatric Blood and
Diseases 2007: 26: pp 700-704.
Haematologica 2008: 93: pp 363-371.
Cancer 2008: 50: pp 52-57.
Risebrough N, Oh P, Blanchette V, Curtin J, Hitzler J,
Scheinemann K, Weitzman S, Hitzler J, Doyle J,
Price VE, Blanchette VS, Ford-Jones EL: The
Feldman B: Cost-utility analysis of Canadian tailored
Abla O: Isolated central nervous system relapse
prevention and management of infections in children
prophylaxis, primary prophylaxis and on-demand
in childhood acute promyelocytic leukemia. Journal
with asplenia or hyposplenia. Infectious Disease
therapy in young children with severe haemophilia A.
of Pediatric Haematology Oncology 2008: 30:
Clinics of North America 2007: 21: pp 697-710.
Haemophilia 2008: April 16 [Epub ahead of print].
pp 160-162.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 81
Shah N, Leaker MT, Teshima I, Baruchel S,
Tabori U, Malkin D: Risk stratification in cancer
Tomlinson D, Isitt JJ, Barron RL, Doyle J, Judd P,
Abdelhaleem M, Ye C: Late-appearing Philadelphia
predisposition syndromes: lessons learned from novel
Gassas A, Naqvi A, Sung L: Determining the
chromosome in childhood acute myeloid leukaemia.
molecular developments in Li-Fraumeni syndrome.
understandability and acceptability of an oral
Pediatric Blood and Cancer 2008: 50: pp 1052-1053.
Cancer Research 200: 68: pp 2053-2057.
mucositis daily questionnaire. Journal of Pediatric
Oncology Nursing 2008: 25: pp 107-111.
Shah NC, Ray A, Bartels U, Rutka J, Bouffet E, Drake J,
Tabori U, Revah G, Nathan P, Rachlis A, Malkin D:
Tomlinson D, Judd P, Hendershot E, Maloney AM,
Hawkins CE, Huang A: Diffuse intrinsic brainstem
Toxicity and outcome of children with treatment-
tumors in neonates. Journal of Neurosurgery,
related acute myeloid leukemia. Pediatric Blood and
Sung L: Establishing literature-based items for an
Pediatrics 2008: 1(5): pp 382-385.
Cancer 2008: 50: pp 17-23.
oral mucositis assessment tool in children. Journal of
Strahm B, Durbin AD, Sexsmith E, Malkin D: The
Teo JT, Klaassen R, Fernandez CV, Yanofsky R,
CXCR4-SDF1 alpha axis is a critical mediator of
Wu J, Champagne J, Silva M, Lipton JH, Brossard J,
rhabdomyosarcoma metastatic signalling induced by
Samson Y, Abish S, Steele M, Ali K, Dower N,
Sung L: Meaurement of oral mucositis in children:
bone marrow stroma. Clinical and Experimental
Uma Athale, Jardine L, Hand JP, Tsangaris E,
a review of the literature. Supportive Care in Cancer
Metastasis 2008: 25: pp 1-10.
Beyene B, Dror Y: Clinical and genetic analysis
2007: 15: pp 1251-1258.
Pediatric Oncology Nursing 2008: 25: pp 139-147.
Tomlinson D, Judd P, Maloney AM, Hendershot E,
of unclassifiable inherited bone marrow failure
Sung L, Lange BJ, Gerbing RB, Alonzo RA and
syndromes. Pediatrics 2008: 122: pp 139-148.
Traivaree C, Blanchette V, Armstrong D, Floros G,
Stain AM, Carcao M: Intracranial bleeding in
Feusner J: Microbiologically documented infections
and infection-related mortality in children with acute
Terasaki M, Bouffet E, Fukushima S, Shigemori M:
haemophilia beyond the neonatal period–the role of
myeloid leukaemia. Blood 2007: 110: pp 3532-3539.
Pilot trial of the rate of response, safety, and
CT imaging in suspected intracranial bleeding.
tolerability of temozolomide and oral VP-16 in patients
Haemophilia 2007: 13: pp 552-559.
Sung L, Nathan PC, Alibhai SMH, Tomlinson G,
with recurrent or treatment-induced malignant central
Beyene J: Meta-analysis: effect of prophylactic
nervous system tumors. Surgical Neurology 2008:
Truong T, Beyene J, Hitzler J, Abla O, Maloney AM,
hematopoietic colony-stimulating factors on mortality
69: pp 46-50.
Weitzman S, Sung L: Features at presentation predict
children with acute lymphoblastic leukemia at low risk
and outcomes of infection. Annals of Internal Medicine
2007: 147: pp 400-411.
Tomlinson D, Bartels U, Hendershot E, Constantin J,
for tumor lysis syndrome. Cancer 2007: 110:
Wrathal G, Sung L: Challenges to participation in
pp 1832-1839.
paediatric palliative care research: a review of the
literature. Palliative Medicine 2007: 5: pp 435-440.
82 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Tsuchida R, Das B, Yeger H, Shibuya M, Baruchel S,
Kirby M: Haematology. In: The Hospital for Sick
A phase I study of IV feneretinide in recurrent
Thorner PS, Malkin D: VEGF/Flt1 signalling regulates
Children Handbook of Pediatrics, 11th Edition.
neuroblastoma. Baruchel S. New Advances
recovery of proliferative capacity of tumor side-
Elsevier, Toronto, 2007.
Neuroblastoma Therapy ($3,200 per patient 2008)
chemotherapy in osteosarcoma. Oncogene 2008:
Malkin D: Molecular biology of childhood neoplasms.
A phase I study of MIBG ultratrace in recurrent
27: pp 3923-3934.
In: Molecular Basis of Cancer, 3rd Edition (Mendelsohn
neuroblastoma. Baruchel S. New Advances
J, Howley PM, Israel MA, Gray JW, Thompson CB, eds.).
Neuroblastoma Therapy ($3,200 per patient 2008)
population cells following exposure to cytotoxic
Villani A, Bouffet E, Blaser S, Millar BA, Bartels UK:
Saunders/Elsevier, Philadelphia, 2008.
A phase I study of sorafenib in recurrent solid tumours.
Inherent diagnostic and treatment challenges in
germinoma of the basal ganglia: a case report and
Malkin D, Helman L: Molecular biology of childhood
Reference laboratory. Wideman B, Baruchel S.
review of the literature. Journal of Neuro-oncology
cancers. In: Principles and Practice of Oncology, 8th
Children’s Oncology Group ($32,000 2007-2008)
2008: 88: pp 309-314.
Edition (DeVita VT, Jr., Hellman S, Rosenberg SA,
eds.). JB Lippincott Co. Philadelphia, 2008.
dietary therapies for cancer. Pediatric Blood and
Cancer 2008: 50: pp 494-497.
Truong T, Weingarten K, Abla O: Oncology. In: The
A phase I/II study of CP751,851 and IGF IR antibody
in refractory/recurrent solid tumours. Baruchel S.
Weitzman S, Egeler MR: Langerhans cell
histiocytosis–update for the pediatrician.
FUNDING
Current Opinion in Pediatrics 2008: 20: pp 23-29.
A group-wide phase II study of ET-743 in recurrent
paediatric sarcoma. Baruchel S. Children’s Oncology
Group ($75,000 2007-2010)
Pfizer ($22,349 per patient 2008-2010)
A phase I/II study of temsirolimus in refractory/
recurrent solid tumours (Funding includes an
additional $31,800 per patient) Baruchel S.
Al-Anazi A, Al-Ansara K, Al-Farsi S, Al-Harbash Z,
Benseler S, Calpin C, Cheng A, Do A, Freedman S,
Sanofi -Aventis Pharmaceuticals
Hospital for Sick Children Handbook of Pediatrics,
11th Edition. Elsevier, Toronto, 2007.
BOOKS AND BOOK CHAPTERS
A phase I study of VEGF trap in children with
refractory solid tumours. Baruchel S.
Weitzman S: Complementary and alternative (CAM)
A phase 1 study of IV feneretinide in recurrent
Harrington L, Jain S, Kirby M: Sickle cell disease. In:
leukaemia and lymphoma–a TACL study. Baruchel S.
The Hospital for Sick Children Handbook of Paediatric
Therapeutic Advances Childhood Leukaemia
Emergency Medicine (Lalani A, Schneeweiss S, eds.).
Consortium ($20,000 per patient 2007)
Wyeth CSA ($75,072 2008-2010)
Jones and Bartlett Publishers, Toronto, 2007.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 83
Child Health Research Institute (Infrastructure for new
A phase II molecularly targeted clinical trial defining
Canadian Centre for Applied Cancer Genetics.
the optimum biological dose of gleevec (imatinib
Malkin D, Weksberg R, Meyn S, Ray P, Becker L,
Research Building). Rossant J, Malkin D, 24 other
mesylate) in paediatric CNS tumours–a multicentre
Rutka J, Yeger H, Zielenska M, Alman B. Canada
co-applicants. Canada Foundation for Innovation
($91 million 2008-2013)
North American study. Baruchel S, Kuttesh J,
Foundation for Innovation 40%, OIT 40%, and
Goldman S, Bouffet E. Novartis Pharmaceuticals
Ballard Foundation 20% of total ($1,811,000
Canada Inc. ($160,000 2003-2008)
2002-2008; additional $216,000 operating funds
Childhood Cancer Survivor Study (CCSS) expansion.
through OIF 2005-2007)
Robison L, Nathan P. National Institute of Health/
National Cancer Institute ($27,365,542 2005-2010)
A phase II study of vinblastine in chemotherapy naive
children with progessive low grade gliomas. Bouffet E,
Cancer and chemosensitivity. Irwin MS. Premier’s
Tabori U, Hawkins C, Keene D. Ontario Institute of
Research Excellence Award ($150,000 2004-2009)
Children with posterior fossa brain tumours: quality of
life and predictors of outcome. Kulkarni A, Bouffet E,
Cancer Research ($430,197 2007-2010)
Career Development Award. Sung L. Canadian Child
Pakulis J, Ellerton C, Shams I. b.r.a.i.n. child
Acute megakaryocytic leukaemia in Down’s syndrome.
Health Clinician Scientist Training Program
($42,685 2006-2008)
Hitzler J. National Cancer Institute of Canada
($280,000 2005-2009)
Chinese immigrant families’ experiences of care for
($137,484 2006-2009)
Careful transitions: developing an integrated service
their child with cancer. Klassen A, Sung L, Raina P,
Biochemical and genetic analyses of JPO2, a novel
delivery model for paediatric palliative care. Antle B,
Shaw N, Dix D, Pritchard S, Poureslami I. Childhood
c-Myc oncogene interacting protein. New investigators
Newman C, Beaune L, Rugg M, Wheat A, Bouffet E,
Cancer Foundation ($92,536 2007-2009)
equipment grant. Huang A. National Cancer Institute
Laxer R, Frager G, Wagner F. SickKids Foundation
of Canada ($29,479 2006-2009)
($129,900 2006-2008)
Clinical Trial Consortium. Pappo A, Bouffet E,
Baruchel S. Ontario Cancer Research Network
($1,000,000 2005-2008)
Biochemical and genetic analyses of JPO2, a novel of
Characterization of generic alterations that converge
c-Myc oncogene interacting protein. Huang A. National
on cell adhesion pathways in paediatric sPNET.
Cancer Institute of Canada ($440,082 2006-2009)
Huang A. b.r.a.i.n. child ($32,000 2008)
Comparative effectiveness of conventional and
Characterization of JPO2, a novel c-Myc co-
trial participation. Gallie BL, Chan HSL, Eysenbach G,
transforming protein. Rodrigues T and Huang A.
Kushniruk A, Heon E. Ontario Institute for Cancer
informatics-assisted clinical management and clinical
Canadian Institute of Health Research Doctoral
Research ($446,066 2003-2006 with two-year no
Research Awards ($63,000 2007-2010)
cost extension 2007-2008)
84 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Complications vasculaires de l’irradiation crânienne
Development of a feasible tool to measure oral
Genetic causes of neutropenia and susceptibility
pour tumeur cérébrale durant l’enfance et
mucositis in children with cancer. Sung L, Judd P,
to leukaemia in patients with inherited neutropenia.
l’adolescence. Bouffet E, Bernier V, de Vathaire F,
Tomlinson D, Doyle JJ, Hendershot EI, Maloney AM,
Dror Y. Neutropenia Association of Canada
Doz F, Grill J, Frappaz D, Plantaz D. Commission
Feldman BM. Paediatric Oncology Group of Ontario
($30,000 2007-2008)
d’Epidémiologie du Conseil de Radioprotection EDF
($13,334 2007-2008)
Genetic determinants of predisposition to childhood
($90,000 2008-2009)
Establishing surrogate markers of angiogenesis in
brain tumour initiation and progression. Tabori U,
Core neuro-cognitive functions in children treated for
paediatric oncology phase I and II clinical trials:
Malkin D. b.r.a.i.n. child ($49,500 2008-2010)
posterior fossa tumours. Mabbott DJ, Bouffet E,
a Children’s Oncology Group Study. Baruchel S,
Noseworthy M, Laughlin S, Kulkarni A, Laperriere N,
Stempak D, Bertolini F, Entz-Werle N. Alex’s
Genetic epidemiology of osteosarcoma. Spector L,
Sharpe M, Keene D, Montour-Proulx I, Briere M,
Lemonade Stand Foundation ($198,417 2007-2009)
Malkin D, Ross J, Sklar C, Nagarajan R. National
Institutes of Health ($1,000,000 2006-2011)
Strother D, Witon A, Wilson B, Chafe S, McConnell D,
Hukin J, Fryer C. National Cancer Institute of Canada
Establishment of a comprehensive genetic bank for
($750,000 2007-2012)
children with brain tumours. Tabori U, Malkin D.
Genetic variation and risk of infection in children with
b.r.a.i.n. child ($42,600 2008-2010)
primary acute myeloid leukaemia. Sung L. Ministry
of Research and Innovation ($100,000 2007-2011)
Cross-cultural validation of the CHO-KLAT (Canadian
Haemophilia Outcomes–Kids’ Life Assessment Tool).
Evaluation of biomarkers in relation to recurrence rate
Blanchette V, Young N, McCusker P. Bayer Health
in childhood ependymoma. Hukin J, Tabori U, Hawkins C.
Genetics, genomic research and consent: attitudes
Care Canada ($260,000 2006-2008)
C-17 Research Network ($140,000 2007-2009)
of paediatric cancer survivors. Patenaude A, Malkin D.
Defining the clinical phenotype of inherited marrow
Functional analysis of the p53 family members
National Institutes of Health ($100,000 2006-2008)
failure syndromes and the risk factors of severe
p73 and p63 roles in apoptosis, development and
Genomic analyses of paediatric supratentorial
haematological complications and cancer by the
cancer. Irwin MS. Canada Research Chair, Tier II
primitive neuroectodermal tumours. Huang A, Li M,
Canadian Inherited Marrow Failure Registry (CIMFR).
($500,000 2003-2008)
Rutka J. American Brain Tumour Association Basic
Science Research Award ($70,000 2006-2008)
Dror Y. Council of Canadian Paediatric Haematology/
Oncology Directors Research Network
Genetic alterations converge on cell adhesion
($83,000 2005-2008)
pathways in childhood sPNET. Huang A.
Brain Tumour Society USA ($200,000 2008-2010)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 85
Group Chair Grant, Children’s Oncology Group.
Infrastructure Grant Paediatric Consortium.
Mechanism of pre-B cell leukemogenesis. Subversion
Institutional Principal Investigator. Malkin D. National
Blanchette VS, Devine S, Weitzman S, Portwine C,
of developmental and survival programs in
Cancer Institute (US$900,000 2003-2008)
Halton J, Jardine L, Silva M. Ontario Cancer Research
leukemogenesis. Guidos C, Hitzler J. Specialized
Network ($990,404 2006-2011)
Center of Research, Leukaemia Lymphoma Society
($750,000 2004-2009)
Hope: the complex journey of parents of children
with cancer. Antle B, Barrera M, Beaune L, Capra M,
Immune thrombocytopenic purpura (ITP) quality
D’Agostino N, Maloney AM, Nicholas D, Volpe J.
of life instrument cross-cultural validation study.
Moderate term musculoskeletal outcomes with
Canadian Institutes of Health Research
Blanchette VS, Klaassen R, Young N. Amgen
escalating dose prophylaxis: the Canadian
($291,067 2005-2008) b.r.a.i.n.child
Canada ($45,000 2007)
Haemophilia Prophylaxis Follow-Up Study (CHPS-3).
International registry of paediatric cutaneous T-cell
2006-2009)
Feldman BM, Blanchette Versus Bayer ($742,500
($25,000 2005-2008)
Identification of genetic pathways that regulate
lymphoma: a longitudinal, prospective, observation
survival and development of cancer and cancer
study of cutaneous T-cell lymphoma in the paediatric
Molecular and pharmacologic correlates of acute
stem cells. Guidos C, Hitzler J. Genome Canada
population. Pope E, Weinstein M, Weitzman S,
myeloid leukaemia in Down syndrome. Taub J, Hitzler J.
($330,000 2005-2009)
Taylor G. Canadian Dermatology Foundation
National Institutes of Health ($2,189,783 2007-2011)
($10,000 2004-2008)
Molecular basis of CNS leukaemia. Subversion of
Identification of interstitial germline deletions in
developmental and survival programs in
children with complex clinical syndromes that
In vivo antitumour and antimetastatic activity of
include medulloblastoma. Taylor M, Bouffet E.
administration of CXCR4 antagonist and anti-CTLA4
leukemogenesis. Danska J, Hitzler J. Specialized
Pediatric Brain Tumour Foundation Institute Award
in neuroblastoma. Baruchel S. Pfizer Canada Inc.
Centre of Research, Leukaemia Lymphoma Society
($100,000 2006-2008)
($45,000 2007-2008)
($750,000 2004-2009)
Identification of leukemogenic genes that convert a
In vivio anti-tumour and anti-metastatic activity of
Molecular determinants of tumour formation in
normal human haematopoietic cell into a leukemic
administration of sutent and low-dose chemotherapy
Li-Fraumeni Syndrome. Malkin D. National Cancer
stem cell. Dick J, Hitzler J. Specialized Centre of
in preclinical neuroblastoma mouse model. Baruchel S.,
Institute of Canada ($423,000 2007-2010)
Research (SCOR), Leukaemia Lymphoma Society
Zhang L. Pfizer Canada Inc. ($50,000 2007-2008)
Grant ($748,575 2004-2009)
86 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
National study of prophylaxis in adolescents and
P53 Family in cancer and chemosensitivity.
Phase II study of high dose chemotherapy with
young adults with inherited severe bleeding disorders.
Irwin MS. Premier’s Research Excellence Award
cyclosporin for vision-threatening intraocular
Carcao MD, Blanchette VB, Chan A, Teitel J, Lillicrap D,
($150,000 2004-2009)
retinoblastoma. Chan HSL, Gallie BL, Heon E. Ontario
Institute for Cancer Research ($551,723 2003-2008)
Wu J. Bayer/Canadian Blood Services/Hema-Quebec
Partnership Fund ($165,899 2007-2008)
P73 Modulatory proteins: roles in apoptosis
and chemosensitivity. Irwin MS. National Cancer
Pilot study of a comprehensive lifestyle program in
Neuro-imaging of white matter and neuro-cognitive
Institute of Canada/Canadian Cancer Society
children receiving treatment for acute lymphoblastic
outcome following cranial radiation for paediatric brain
($400,682 2007-2010)
leukaemia (ALL). Nathan P, Wright M, Collins L, Birken
C, Dettmer E. Pediatric Oncology Group of Ontario
tumours. Mabbot DJ, Bouffet E, Noseworthy M,
Suzanne M, Kulkarni A, Norman L, Michael S,
Paediatric Phase I Consortium. Baruchel S, Pappo A,
Montour-Proulx I, Daniel K, Strother D, Witol A,
Gammon J. National Cancer Institute/Children’s
Wilson B, Chafe S, McConnel D, Hukin J, Freyer C.
Oncology Group ($250,000 2002-2007)
($15,000 2008)
Pilot study of once-a-day prophylaxis for youth and
young adults with severe haemophilia A. Feldman B,
C17 Research Network ($95,000 2006-2008)
Neuroblastoma stem cell bank and a preclinical
Pain in child health: an innovative, transdisciplinary,
Rivard G, Carcao M, St-Louis J, Teitel J, Pullenayegum E,
cross-Canada research training consortium. McGrath PJ,
Blanchette V. Bayer/Talecris/Canadian Blood
research unit in novel therapeutic drug discovery.
Barr R, Baruchel S, Brown S, Camfield C, Chambers C,
Services/Hema-Quebec Partnership Fund ($200,000
Baruchel S. Solving Kids Cancer NYC
Connolly J, Craig K, Dube L, Feldman B, Finley G, Frager G,
2007-2009)
($400,000 2008-2009)
Gibbins S, Grunau R, Harman K, Hetherington C,
Howlett A, Johnston C, Kenny N, Koren G, Langer J,
Predicting the risk of infection in children receiving
New surrogate markers of angiogenesis in paediatric
Murray M, Oberlander T, Ohlsson A, Otley A, Rathwell T,
chemotherapy for acute myeloid leukaemia. Sung L,
brain tumours. Baruchel S, Bartels U, Hawkins C,
Salter M, Schellinck H, Stevens B, Taddio A, Unruh A,
Allen U, Beyene J. Canadian Institute for Health
Stempak D, Bouffet E, Abdelhaleem M, Doyle J.
Von Baeyer C, Walker C. Canadian Institutes of Health
Research ($582,104 2008-2012)
b.r.a.i.n.child ($97,446 2006-2008)
Research ($1,800,000 2002-2008)
Predicting the risk of infection in children receiving
chemotherapy for acute myeloid leukaemia. Sung L,
Orphan late effect in paediatric brain tumour survivors.
Palliative chemotherapy versus supportive care alone
Lafay-Cousin L, Sockett E, Bouffet E. b.r.a.i.n.child
for end-of-life. Sung L, Hinds P, Llewellyn-Thomas H,
Beyene J, Allen U. National Cancer Institute of
($30,000 2005-2007)
Volpe J, Capra M, Gammon J, Baruchel S, Bouffet E,
Canada ($817,963 2008-2012)
Barrera M, Tomlinson D, Greenberg ML. National
Cancer Institute of Canada ($131,626 2005-2008)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 87
TACL 2006-001: a phase I study of intravenous
Presentation, management and outcomes evaluation
South Asian immigrant families’ experiences of care
of children with vascular tumours. Pope E, Mahant S,
for their child with cancer. Klassen A, Sung L, Raina P,
fenretinide in children with recurrent or resistant ALL,
Blanchette V, Weitzman S, Baruchel S, John P,
Shaw N. National Cancer Institute of Canada
AML and NHL. Harned T, Maurer B, Punnett A.
Brandao L. The Hospital for Sick Children Paediatric
($139,067 2007-2009)
Therapeutic Advances in Childhood Leukaemia
($20,000 per patient 2007)
Consultants Partnership’s Grant ($9,900 2006-2008)
Subversion of developmental and survival programs in
Prognostic and therapeutic implications for telomere
leukemogenesis. Project 1: identification of
Telomere maintenance in the biologic behaviour of low-
maintenance and telomerase inhibition in paediatric
leukemogenic genes that convert a normal human
grade gliomas. Malkin D, Tabori U. b.r.a.i.n. child
high grade gliomas. Tabori U. Canadian Institute for
hematopoietic cell into a leukemic stem cell. Mak T,
($60,000 2004-2007)
Health Research ($385,811 2008-2011)
Dick J, Hitzler J. Leukaemia Lymphoma Society
($748,575 2004-2009)
Thalassemia Clinical Research Network Registry. Kirby M.
National Institutes of Health ($45,696 2005-2010)
Prospective cohort study of genetic variation and
risk of infection in Canadian children with newly
Subversion of developmental and survival programs in
diagnosed acute myeloid leukaemia. Sung L, Beyene J,
leukemogenesis. Project 2: mechanism of pre-B cell
The biologic and prognostic role of replicative
Allen U. National Cancer Institute of Canada
leukemogenesis. Guidos C, Hitzler J. Leukaemia
and oncogene induced senescence in paediatric
($444,424 2005-2008)
Lymphoma Society ($750,000 2004-2009)
low grade gliomas. Tabori U. Brain Tumour Society
($220,000 2007-2009)
Role of p73 in neuroblastoma and sensitivity to
Subversion of developmental and survival programs in
The effects of additional videotaped information on
therapy. Irwin MS. Elsie Winifred Crann Memorial
leukemogenesis. Project 3: molecular basis of CNS
Trust Award for Research in Life Sciences, University
leukaemia. Danska J, Hitzler J. Leukaemia Lymphoma
the experience of parents of children with newly
of Toronto ($35,000 2008-2010)
Society ($750,000 2004-2009)
diagnosed acute lymphoblastic leukaemia (ALL). Abla
Sibling and parent bereavement from childhood
TACL 2005-003: a study of bortezomib with
H. Novopharm/Childhood Cancer Foundation Grant
cancer. Gerhardt C, Barrera M, Capra M. National
chemotherapy for relapsed/refractory acute
($75,000 2008)
Cancer Institute of Canada/The Hospital for Sick
lymphoblastic leukaemia. Messinger Y, Bostrom B,
Children ($92,000 2005-2010)
Punnett A. Therapeutic Advances in Childhood
The genetic basis of severe sickle cell disease:
Leukaemia ($20,000 per patient 2007)
the never lost international cohort study. Children’s
O, Punnett A, Barrera M, Hetherington R, Rolbin-Tseitlin
Discovery Institute ($149,968 2008-2012)
88 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Validation of a new paediatric scoring system from the
The Kids’ ITP Tools (KIT). Licensing. Blanchette VS,
The role of VPS33B in platelet alpha granule formation.
Young N, Klaassen R, Barnard D. Amgen Canada
Kahr WHA. Heart and Stroke Foundation of Ontario
International Haemophilia Prophylaxis Study Group:
($90,000 2007)
($210,750 2006-2009)
validity and reliability of the combined haemophilia
The Ontario Paediatric Oncology Clinical Trials
The role of VPS33B in platelet alpha granule formation.
Funk S, Bergstrom BM, Zourikian, Hilliard P,
Research Network. Blanchette V, Malkin D, Devine S,
Kahr WHA. Canadian Institutes of Health Research
van der Net JJ, Engelbert R, Petrini P, van den Berg HM,
Baruchel S, Weitzman S, Bouffet E. Ontario Cancer
Canada ($441,912 2006-2010)
Manco-Johnson M, Rivard G. Bayer Healthcare LLC,
joint health score (HJHS). Feldman B, Blanchette VS,
Biological Products Division ($195,000 2005-2007)
Research Network ($1.2 million 2006-2009)
To improve infrastructure for paediatric cancer clinical
The prevalence of symptomatic von Willebrand disease
trials. Pappo A, Malkin D, Devine S, Hitzler H, Silva M,
Validation of the oral mucositis daily questionnaire and
in the paediatric population. James PD, Blanchette VS,
Barr R, Halton J, Jardine L, Baruchel S, Bouffet E.
evaluation of importance of mucositis in children with
Lillicrap D, Silva M, Rand ML, Brandao L. Canadian
Ontario Cancer Research Network ($990,404
acute leukaemia, non-Hodgkin’s lymphoma and stem
Haemophilia Society ($139,800 2007-2009)
2005-2010)
cell transplantation recipients. Sung L, Tomlinson D,
Judd P, Gassas A, Naqvi A, Doyle J. Connaught New
The role of SBDS in granulopoiesis. Dror Y.
SickKids Foundation ($64,480 2006-2008)
Staff Matching Grant ($29,978 2008-2010)
Treatment choices for children with typical acute
immune thrombocytopenic purpura: development of a
decision aid. Beck C, Parkin P, Birken C, Blanchette V,
Validation of the oral mucositis daily questionnaire
The role of SBDS in promoting cell survival.
Boydell K, Llewellyn-Thomas H. Dean’s Fund New
and evaluation of importance of mucositis in children
Dror Y. Canadian Institutes of Health Research
Staff Competition ($10,000 2006-2011)
with acute leukaemia, non-Hodgkin’s lymphoma
and stem cell transplantation recipients. Sung L,
($250,000 2006-2011)
Understanding collaboration in a shared care practice
Tomlinson D, Judd P, Gassas A, Naqvi A, Doyle J.
The role of SBDS in promoting cell survival.
of paediatric oncology patients: a pilot study. Punnett A,
Pediatric Oncology Group of Ontario ($13,166 2008-2009)
Dror Y. SDS Project Inc. ($60,000 2006-2008)
Lingard L. The Hospital for Sick Children Paediatric
Consultants Partnership’s Grant ($7,024 2007-2008)
The roles of the novel p53 family proteins in
Weekly vinblastine for chemotherapy naГЇve children
with progressive low grade glioma. Bouffet E, Pond G,
cancer and chemosensivity. Irwin MS. Canada
Moghrabi A, Carret AS, Jabado N, Samson Y, Crooks B,
Research Chair, Tier II Renewal (Salary Award)
Hand JP, Strother D, Wilson B, Hukin J, Mpofu C,
($500,000 2008-2013)
Whitton A, Zelcer S, Silva M, Brossard J, Johnston D,
Keene D, Bartels U, Tabori U, Hawkins C. Ontario
Institute of Cancer Research ($536,885 2007-2010)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 89
Dr. Chaim Roifman
DIVISION HEAD
Dr. Chaim Roifman
FULL-TIME
Dr. Adelle Atkinson
Dr. Eyal Grunebaum
PART-TIME
Dr. Milton Gold
Dr. David Hummel
Dr. Sasson Lavi
Dr. Maria Triassi
Dr. Stephen Feanny
CLINICAL FELLOWS
Dr. Fotini Kavadas
Dr. Elana Lavine
Dr. Amit Nahum
Dr. Vy Kim
Dr. Nashat Al-Sukaiti
CLINICAL ASSISTANT
Dr. Julia Upton
ALLERGY NURSE
Elisabeth White
IMMUNOLOGY NURSE
Brenda Reid
SENIOR SCIENTIST
Dr. Amos Cohen
RESEARCH ASSOCIATE
Dr. Nigel Sharfe
Division of Immunology/Allergy
OVERVIEW
The Hypogammaglobulinemia Program at SickKids is
cent survival rate is achieved by a widely used
The Division of Immunology/Allergy continues as a
recognized globally for its innovative approach and
standard protocol exercised in most other countries
leader in patient care, research and education in
long-term follow up of over 150 patients. We
in Europe and the U.S. Our protocol has become
the benchmark for treatment of severe combined
immunology. This year marks the launch of the
transformed the therapy of these patients from
International Network of JMF Centres of Excellence
multiple hospital-based admissions to visiting the
immunodeficiency when a full HLA-matched related
in Immunodeficiency. Under Dr. Roifman’s leadership,
short stay unit and subsequently receiving treatment
donor is not available and it has been adapted by many
transplant centres across the world. In addition, we
these international programs are facilitating early
in their community. The proficiency of our team,
recognition, diagnosis, research and effective
coupled with convenient care at a medical centre
have shown that this protocol has excellent results
treatment of primary immune deficiencies. The
close to home, provides our patients with the
in a group of patients with residual T-cells.
network will collaborate with the NIH (U.S.A.) on a
personalized treatment they require. To further
12-month grant program in support of research in
enhance this program, we are now implementing
Our scientific and clinical achievements lead to much
primary immunodeficiency (PID).
home therapy as the ideal model of treatment. Our
recognition. This includes membership by Dr. Roifman
recent symposium for a Canadian consensus on home
in the World Health Organization Scientific Committee
The Primary Immunodeficiency Program at The Hospital
treatment has resulted in funding by the Canadian
for Clinical Immunology, which defines the
for Sick Children is the largest centre of its kind in
Immunodeficiency Society and a publication in the
classification of PIDs. Similarly, we are commonly
Canada and one of the largest in the world. Medical
Journal of Clinical Immunology.
editing a clinics of North America book on intravenous
immunoglobulin therapy.
services are provided to over 2,000 outpatients
referred from physicians and hospitals nationally.
Innovative protocols created by members of the
This number has steadily increased by 30 per cent
division have elevated the profile of the Bone Marrow
Research remains a major focus of activity in the
over the last 10 years. To diminish waiting time in the
Transplantation (BMT) Program as one of the best in
division. Dr. Roifman’s laboratory continues to develop
Immunology Clinic, we have recently established the
the world for survival of PID patients. In 1990, we
innovative anti-cancer treatments. Novel compounds
Complex Immunodeficiency Clinic. This addition has
pioneered the implementation of matched unrelated
were designed against targets in solid tumours which
improved evaluation of our complex patients by
donor transplants for PID patients. Today, we
have led to significant tumour shrinkage in vitro and in
providing extensive time and attention to their
demonstrate the impact of our procedures with recent
vivo. Moreover, since Dr. Roifman’s lab synthesized
conditions.
publications in JAMA, BMT and JACI. These papers
CR4, another novel compound capable of killing
illustrate an 80 per cent survival rate for SickKids’
acute lymphocytic leukaemia (ALL) and acute myeloid
patients utilizing our protocol and in some publications
leukaemia (Blood 2003), it is currently being given
100 per cent survival rate. In contrast, only a 50 per
to patients with ALL in a phase one clinical study
RESEARCH TECHNOLOGISTS
Lorand Cimpeon
Tom Grunberger
Yiping Gu
Vivien Lee
Weixian Min
Alka Arora
Yongmao Yu
Murugesapillai Mylvaganam
JunYan Zhang
MEDICAL LAB
TECHNOLOGISTS
Andrea Bates
Dr. Harjit Dadi
ADMINISTRATIVE STAFF
Jayne Enhaynes
Ellis Dervis
Sandra Mendonca
conducted by LymphoSign. Recently, novel compounds
Education remains an important activity of every
HONOURS AND AWARDS
which effectively kill multiple myeloma cells have been
member of the division. The tireless dedication to
Roifman CM: Schwartz-Reisman Israel Scholar, 2007.
synthesized and tested. Meanwhile, the discovery of a
teaching by your has recently been recognized by
genetic aberration in the RNA component of RMRP has
the approval of reviewers from the Royal College
Roifman CM: Chair of the Jeffrey Modell Centres
initiated testing of patients for this defect (JACI 2006).
of Physicians and Surgeons. Beyond this program,
Network, 2007.
we continue to attract more than 25 outstanding
Dr. Grunebaum and his group have successfully
candidates every year from across the world.
Reid B: Nurses Awareness Initiative, Canadian
developed and described a novel method to efficiently
International trainees have the opportunity to
Immunodeficiency Society, 2007.
deliver full length enzymes such as purine nucleoside
participate in a flexible program which can be
phosphorylase (PNP) into cells (Journal of Clinical
predominantly research oriented. Our commitment
PUBLICATIONS
Investigation 2006). To further this endeavour, his
to education goes beyond the training program.
Al-Jenaidi F, Outi M’ekitie O, Grunebaum E, Sochett E:
laboratory continues to develop safer methods of
Dr. Roifman established a new international fellowship
Parathyroid gland dysfunction in 22q11.2 deletion
syndrome. Hormone Research 2007: 67: pp 117-122.
inserting genes into bone marrow cells. This will
program, The Robert A. Good/JM Fellowship in
facilitate therapy for diseases such as PNP and
Immunodeficiency and Transplantation. In addition,
adenosine deaminase (ADA) deficiency, while
Dr. Adelle Atkinson was granted the CI Society
AL-Zahrani D, Gruneabum E, Roifman CM: Safety
Physician’s Awareness Award for a third consecutive
and efficacy of measles-mumps-rubella vaccine
year. Similarly, Brenda Reid was presented with a
on patients with DiGeorge/22q11 microdeletion
In view of his academic achievements and his multiple
nursing education grant by the CI Society for her
syndrome. Pediatric Academic Society 2007:
contributions to clinical immunology in Canada, the
leadership in the teaching of PID care to nurses globally.
61: p e6293.14.
Launched in 2007, the recipients of this research
Thanks to the support of the Donald & Audrey
Atkinson AR, Roifman CM: Low serum IgG2 levels
improving the substandard outcomes for these patients.
CI Society created the Chaim Roifman Scholar Award.
grant will study the clinical, cellular and molecular
Campbell Chair, the Jeffrey Modell Foundation, the CI
in infancy can be transient. Pediatrics 2007: 120:
characteristics of genetically determined immunodeficiency
Society, Canadian Institute of Health Research, March
pp e543-e574.
diseases, discover improved diagnostic tools for PID,
of Dimes, and the Canadian Centre for Primary
research novel therapeutic approaches for PID, or
Immunodeficiency, children who come for treatment in
advance education of patients and medical
our division will receive the best care possible, as
professionals on PIDs.
soon as possible.
92 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Geha RS, Notarangelo LD, Casanova JL, Chapel H,
Kavadas F, Somech R, Pollanen M, Roifman CM:
Manlhiot C, Tyrrell PN, Liang L, Atkinson AR, Lau W,
Conley ME, Fischer A, Hammartrom L, Nonoyama S,
Hemophagocytic lymphocytosis in a patient with
Feldman BM: Safety of intravenous immunoglobulin in
Ochs HD, Puck J, Roifman CM, Seger R, Wedgwood J:
T-B+NK severe combined immunodeficiency.
the treatment of junvenile dermatomyositis: adverse
Primary immunodeficency diseases: an update from
Pediatric Academic Society 2007: 61: pp e6286.9.
reactions are associated with immunoglobulin A
content. Pediatrics 2008: 121(3): pp e626-e630.
the International Union of Immunological Societies
Primary Immunodeficiency Diseases Classification
Ku CL, von Bernuth H, Picard C, Zhang SY, Chang HH,
Committee Meeting. Journal of Allergy and Clinical
Yang K, Chrabieh M, Issekutz AC, Cunningham CK,
Nofech-Mozes Y, Blaser SI, Roifman CM: Neurological
Immunology 2007: 120(4): pp 776-794.
Gallin J, Holland SM, Roifman CM: Selective
manifestations in severe combined immunodeficiency
predisposition to bacterial infections in IRAK-4
secondary to adenosine deaminase deficiency.
Grunebaum E, Notarangelo LD, Roifman CM:
deficient children: IRAK-4 dependent TLRs are
Pediatric Neurology 2007: 37(3): pp 218-221.
Successful correction of severe combined immune
otherwise redundant in protective immunity. Journal of
deficiency following transplantation with bone
Experimental Medicine 2007: 204(10): pp 2407-2422.
Roifman CM, Grunebaum E, Dalal I, Notorangelo LD:
Lai YH, Gruneabum E, Atkinson A, Cutz E, Roifman
combined immunodeficiency. Immunologic Research
CM: Pulmonary and hepatic disease in a patient with
2007: 38: p 191.
Matched unrelated bone marrow transplant for severe
marrow from HLA-matched unrelated donors.
Italian Journal of Pediatrics 2007: 33: pp 24-26.
Grunebaum E, Roifman CM: Clinical and immunological
partial adenosine deaminase (ADA) deficiency.
features of patients with WHIM syndrome (warts,
Pediatric Academic Society 2007: 61: p e6286.5.
Somech R, Seaban-Adel K, Kirby-Allen M, Atkinson AR:
Evaluation and management of pediatric patients with
hypogammaglobulinemia, infections and myelokathexis)
with or without mutations in the CXCR4 gene. Pediatric
Lavine E, Picard C, Casanova JL, Roifman CM: Cellular
anaphylactoid reactions to deferoxamine mesylate.
Academic Society 2007: 61: p e6286.1.
and humoral aberrations in a kindred with IL-1 receptor
Annals of Allergy, Asthma and Immunology 2007:
associated kinase 4 deficiency. Journal of Allergy and
99(6): pp 575-576.
Husain M, Grunebaum E, Naqvi A, Atkinson A,
Clinical Immunology 2007: 120(4): pp 948-950.
Somech R, Grunebaum E, Roifman CM: Short-lived
Ngan BY, Aiuti A, Roifman CM: Burkitt lymphoma in
antibody response as a manifestation of primary
adenosine deaminase deficient-severe combined
Lavine E, Roifman CM: Clinical course and
immunodeficiency treated with polyethylene glycol-
immunological features of siblings with IRAK-4 deficiency.
immunodeficiency. Pediatric Academic Society 2007:
adenosine deaminase. Journal of Pediatrics 2007:
Pediatric Academic Society 2007: 61: p e6286.6.
61: p e6286.2.
151: pp 93-95.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 93
BOOKS AND BOOK CHAPTERS
FUNDING
Irwin J, Atkinson AR: What’s a mother to do? In:
A clincial study of the pharmacokinetics, efficacy
by prolonged intracellular enzyme replacement
Anaphylaxis Canada Newsletter. Anaphylaxis Canada,
and safety of immune globulin intravenous (human)
therapy. Grunebaum E. March of Dimes ($390,000
Omr-IgG-am IGIV in subjects with primary immune
2007-2010)
Toronto, 2007.
Correcting purine nucleoside phosphorylase deficiency
deficiency diseases. Roifman CM, Roberts R,
Kim Vy, Atkinson AR: Allergy and immunology.
Melamed IR, Moy J, Grunebaum E, Sussman GL,
Correcting purine nucleoside phosphorylase using
In: The Hospital for Sick Chidlren Handbook of
Chouksey A, Stein M, Wasserman RL, Levy R, McNeil
lenti-virus mediated human PNP gene delivery into
Pediatrics (Bismilla Z, Gupta S, Lam C, eds.).
D, Suez D. FFF Enterprises ($550,000 2006-2008)
haematopoietic stem cells. Grunebaum E. SickKids
Foundation/Canadian Institutes of Health Research/
Elsevier, Toronto, 2008.
A clinical study of the pharmacokinetics, efficacy
Institute of Human Development, Child and Youth
Roifman CM: Human interleukin-2 receptor alpha
and safety of immune globulin intravenous (human)
Health ($130,000 2006-2008)
Deficiency. In: Primary Immunodeficiency Diseases: A
Omr-IgG am’99 IGIV in subjects with primary immune
Molecular and Genetic Approach (Ochs HD, Smith CIE,
deficient diseases. Grunebaum E, Somech R.
Puck JM, eds.). Oxford University Press, New York, 2007.
FFF Enterprises ($55,000 2007-2008)
Correcting PNP deficiency by intracellular delivery of
PNP fused to protein transduction domains.
Grunebaum E. US Immunodeficiency Network
Sharfe N, Roifman CM: ZAP-70: 15 years on and still
Canadian Centre for Primary Immunodeficiency.
an expanding world. In: Lymphocyte Activation and
Roifman CM. Canadian Centre for Primary
Signal Transduction. Transworld Research Network,
Immunodeficiency ($410,000 2003-2007)
India, 2007.
94 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
(US$330,000 2006-2008)
Fellowship in immunology. Roifman CM. Canadian
Friends of Tel-Aviv University ($55,000 2006-2007)
Genetics of primary immunodeficiency. Roifman CM.
Novel synthetic styryl-acrylonitrile inhibitors of tumour
Primary immunodeficiency (PID) Registry. Roifman CM.
Canadian Immunodeficiency Society ($100,000
angiogenesis: in vivo translation. Roifman CM. Ontario
Canadian Blood Services/Bayer ($194,150 2004-2008)
2007-2010)
Cancer Research Network ($512,179 2004-2007)
Home immunoglobulin therapy. Roifman CM. Canadian
Nursing awareness for primary immune deficiency.
diseases. Grunebaum E. Jeffrey Modell Foundation
Immunodeficiency Society ($430,000 2007-2011)
Reid B. Canadian Immune Deficiency Society
($11,000 2006-2007)
Retrovirus gene therapy for primary immunodeficiency
($6,500 2007)
Immunology and transplantation. Roifman CM.
Role of Eph receptors in the immune system.
McMillan Binch Barristers and Solicitors ($75,000
Pathogenesis of immune malignancies. Roifman CM.
Roifman CM. Canadian Institutes of Health Research,
2002-2007)
Audey Stanleigh Leukaemia Research Foundation
2nd renewal ($350,000 2004-2007)
($52,500 2005-2008)
Molecular basis of primary immunodeficiency. Roifman
CM. Jeffrey Modell Foundation ($250,000 2006-2011)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 95
Dr. Ian Kitai
Dr. Anupma Wudhwa
DIVISION HEAD
Dr. Upton Allen
FULL-TIME
Dr. Sean Ari Bitnun
Dr. Anne G. Matlow
Dr. Anne Opavsky
Dr. Stanley E. Read
Dr. Dat Tran
Dr. Anupma Wadhwa
Dr. Valerie Waters
PART-TIME
Dr. Jason Brophy
Dr. Ian Kitai
Dr. Alana Rosenthal
CROSS-APPOINTEES
Dr. Susan Richardson
Dr. Sharon Walmsley
Dr. Elaine Wang
HONORARY
Dr. Susan King
CLINICAL FELLOWS
Dr. Tariq Al Fawz
Dr. Amal Al-Maani
Dr. Hadi Al-Qahtani
Dr. Michelle Bridge
Dr. Yuho Horikoshi
Dr. Spenta Kakalia
Dr. Fatima Kakkar
Dr. Jackeline Pando Kelly
Dr. Caroline Kerrison
Dr. Ronan Timothy Leahy
Dr. Shaun Morris
Dr. Wilson Pau
RESEARCH FELLOWS
Dr. Michelle Barton-Forbes
Dr. Spenta Kakalia
Dr. Sean O’Riordan
Division of Infectious Diseases
OVERVIEW
Our research initiatives are structured around themes
In the area of education, representatives from our
The Division of Infectious Diseases is a leader in clinical,
that include host susceptibility and related factors
division continue to play a key role in activities of the
educational and research activities locally, nationally
and innovative antimicrobial and associated therapies.
Royal College of Physicians and Surgeons of Canada,
and internationally. The division has active inpatient as
Specific research initiatives include multicentred
and in many areas of undergraduate, graduate, post
well as ambulatory consultant services that include
paediatric HIV studies related to maternal-to-child
graduate and continuing medical education activities.
teams that focus on general infectious diseases and
transmission and studies on new antiretrovirals,
Faculty members continue to hold editorships, visiting
infectious diseases in immunocompromised hosts,
vaccine studies and research into the mechanisms of
professorships and related academic honours
respectively. We are a resource for issues related to
host susceptibility to viral infections. These infections
nationally and internationally.
infectious disease outbreaks, including new and
include viral myocarditis, influenza illness, HIV,
emerging infections, infection control and the
EBV-related post-transplant lymphoproliferative
HONOURS AND AWARDS
specialized areas of HIV, congenital infections,
disorder (PTLD) and encephalitis. Multicentred trials
Allen U: Advanced to Fellow, Infectious Diseases
management of infectious complications or organ
related to the diagnosis and prevention of infections
Society of America.
transplantation, and the ever-increasing problem
in transplant patients are ongoing, as well as
of multi-drug resistant tuberculosis.
participation in national surveillance studies (IMPACT)
Allen U: Honorary Fellowship, Royal College of
and national collaborative paediatric studies through
Physicians of UK.
Division members play a leading role in national
the Paediatric Investigators Collaborative Network on
and international epidemiological, clinical, research
Infections in Canada (PICNIC). Our research in
Allen U: Invited discussant. Challenging cases:
advisory and related committees (e.g., the Infectious
infection control includes the clinical and molecular
annual meeting. Infectious Diseases Society of
Diseases Society of America, the Canadian Paediatric
epidemiology of paediatric nosocomial infections.
America, San Diego, CA, 2007.
Transplantation, the Government of the Bahamas
The division has continued to have a leadership role in
Allen U: Keynote lecture – 60th anniversary,
and the HIV/AIDS program in Russia).
structuring the approach to the management of major
Faculty of Medicine, University of the West Indies.
Society, Health Canada, the American Society for
emerging and resurgent infectious disease threats. In
this regard, the division has been very actively
Allen U: Visiting professor and external examiner,
involved in influenza pandemic planning efforts at
University of West Indies, Jamaica.
SickKids as well as provincially and nationally.
CLINICAL NURSES
Debra Louch
Georgina MacDougall
RESEARCH ASSOCIATE
Dr. Nasser Khodai Booran
CLINICAL RESEARCH NURSE
COORDINATORS
Cheryl Arneson
Suganya Lee
Brenda O’Doherty
Kim Simpson
ADMINISTRATIVE STAFF
Brenda Bishop
Marsha Frances-Reid
Savannah Hatt
Wayne Moore
Zita Rotar
Bebi Wali
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 97
Brophy J: Clinical Track Rapporteur, Canadian
Allen U and the Infectious Diseases and Immunization
Allen U and the Infectious Diseases and Immunization
Association for HIV Research, 2007.
Committee, Canadian Pediatric Society: Human
Committee, Canadian Paediatric Society: West Nile
papillomavirus vaccine for children and adolescents.
virus in the context of climate change. Paediatrics and
Paediatrics and Child Health 2007: 12: pp. 599-603.
Child Health 2008: 13: pp. 399-400.
Allen U and the Infectious Diseases and Immunization
Amin R, Richardson SE, MacGregor D, Tellier R, Heurter
Matlow A. Sydney Marie Snyder Endowed Lectureship,
inaugural talk: To err is human but what about the
kids? Children’s National Medical Centre, Washington,
DC, 2008.
PUBLICATIONS
Committee, Canadian Paediatric Society: Infection
H, Fearon M, Ford-Jones E, Bitnun A: Acute childhood
control in paediatric office settings. Paediatrics and
encephalitis and encephalopathy associated with
Child Health 2008: 13: pp. 408-419.
influenza: a prospective 11-year review. Pediatric
Infectious Disease Journal 2008: 27: pp 390-395.
Allen U: Current status and impact of CMV prevention
following pediatric organ transplantation. Pediatric
Allen U and the Infectious Diseases and Immunization
Transplantation 2008: 12: pp 389-392.
Committee, Canadian Pediatric Society: Needle stick
injuries in the community. Paediatrics and Child
for preventing and treating influenza in children:
Allen U: Immunizations for children with cancer.
Health 2008: 13: pp. 205-210.
commentary. Evidence-Based Child Health 2008:
Barton MA, Allen U: Neuraminidase inhibitors
3: pp 585-588.
Pediatric Blood and Cancer 2007: 49(S7): pp
1102-1108.
Allen U and the Infectious Diseases and Immunization
Committee, Canadian Pediatric Society: Prevention of
Brophy J, Yau Y, Cox P, Katz K, Bitnun A: A sentinel
Allen U and the Infectious Diseases and Immunization
congenital rubella syndrome. Paediatrics and Child
fatal paediatric case of community associated
Committee, Canadian Pediatric Society: Antifungal
Health 2007: 12: pp. 795-77.
methicillin-resistant Staphylococcus aureus in Canada.
Paediatrics and Child Health 2007: 12 pp 319-322
agents for common pediatric infections. Paediatrics
and Child Health 2007: 12: pp. 875-878.
Allen U and the Infectious Diseases and Immunization
Committee, Canadian Pediatric Society: Testing for
Conwell LS, Forrest CR, Allen U, Perlman K,
Allen U and the Infectious Diseases and Immunization
HIV infection in pregnancy. Paediatrics and Child
Daneman D: Necrotizing fasciitis in adolescents with
Committee, Canadian Pediatric Society: Autistic
Health 2008: 13: pp. 221-224.
poorly controlled Type 1 diabetes mellitus: report of
two cases. Pediatric Diabetes 2007: 8: pp 397-400.
spectrum disorder: No causal relationship with
vaccines. Paediatrics and Child Health 2007:
Allen U and the Infectious Diseases and Immunization
12: pp. 393-395.
Committee, Canadian Pediatric Society: Therapy of
suspected bacterial meningitis in Canadian children
six weeks of age and older. Paediatrics and Child
Health 2008: 13: p 309.
98 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Elbers J, Bitnun A, Richardson SE, Ford-Jones L, Tellier
Kam A, Ford-Jones L, Malloy P, Khan K, Kitai I: Active
Matlow A, Stevens P, Urmson L, Wray R. Improving
R, Wald R, Petric M, Kolski H, Heurter H, MacGregor
tuberculosis among adolescents in Toronto, Ontario:
patient safety through a multi-faceted internal
D: Childhood herpes simplex encephalitis: a 12-year
clinical features and delays in diagnosis. Pediatric
surveillance program. Healthcare Quarterly 2008:
prospective study of childhood herpes simplex
Infectious Diseases Journal 2007: 26: pp 355-356.
11(3): pp 101-108.
Paediatrics 2007: 119: pp 399.
Koo A, Sung L, Allen U, Naqvi A, Drynan-Arsenault J,
Ofner-Agostini M, Johnston BL, Simor AE, Embil J,
Dekker A, Dupuis LL: Efficacy and safety of
Matlow A, Mulvey M, Ormiston D, Conly J, Canadian
Gravel D, Taylor G, Ofner M, Johnston L, Loeb M,
caspofungin for the empiric management of fever in
Nosocomial Infection Surveillance Program:
Roth VR, Stegenga J, Bryce E: The Canadian
neutropenic children. Pediatric Infectious Diseases
Vancomycin-resistant enterococci in Canada: results
Nosocomial Infection Surveillance Program, Matlow A:
Journal 2007: 26: pp 700-704.
encephalitis: is there a broader spectrum of disease?
from the Canadian nosocomial infection surveillance
program, 1999-2005. Infection Control and Hospital
Point prevalence survey for health care-associated
Epidemiology 2008: 29(3): pp 271-274.
infections within Canadian adult acute-care hospitals.
Kumar D, Humar A, Plevneshi A, Siegal D, Franke N,
Journal of Hospital Infection 2007: 66(3): pp 243-248.
Green K, McGeer A, Matlow A: Toronto Invasive
Bacterial Diseases Network: Invasive pneumococcal
Ota K, Profiti R, Smaill F, Matlow A, Smieja M:
Grisaru-Soen G, Lau W, Arneson C, Louch D, Read SE,
disease in adult hematopoietic stem cell transplant
Identification badges: a potential fomite? Canadian
Journal of Infection Control 2007: 22(3): pp 165-166.
Bitnun A, Stephens D, King SM: A randomized
recipients: a decade of prospective population-based
trial (RCT) to assess the effect of withdrawal of
surveillance. Bone Marrow Transplantation 2008:
intravenous immune globulin (IVIG) therapy for
41(8): pp 743-747.
Ramphal R, Grant RM, Dzolganovski B, Constantin J,
Tellier R, Allen U, Weitzman S, Matlow A, Petric M,
selected children with HIV infection. Pediatrics
Manlhiot C, Liang L, Tran D, Bitnun A, Tyrrell PN,
Sung L: Herpes simplex virus in febrile neutropenic
Feldman BM: Assessment of an infectious disease
children undergoing chemotherapy for cancer: a
Hawkes M, Barton-Forbes M, Conly J, Nicolle L,
history preceding juvenile dermatomyositis symptom
prospective cohort study. Pediatric Infectious
Barry C, Ford-Jones EL: Superbug at our doorstep.
onset. Rheumatology 2008: 47: pp 526-529.
Diseases Journal 2007: 26(8): pp 700-704.
International 2007: 49: pp 972-977.
Canadian Medical Association Journal 2007: 176:
pp 54-56.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 99
Waters VJ, Gomez MI, Soong G, Amin S, Ernst R,
Salter R, King SM, Smith ML, Bitnun A, Brophy J,
Simor AE, Stuart TL, Louie L, Watt C, Ofner-Agostini M,
Fernandes-Penney A, Lefebvre A, Louch D, MacDougall
Gravel D, Mulvey M, Loeb M, McGeer A, Bryce E,
Prince A: Immunostimulatory properties of the
G, Moore W, Read SE: Disclosing HIV diagnosis to
Matlow A: Canadian Nosocomial Infection Surveillance
emerging pathogen Stenotrophomonas maltophilia:
Infectious Immunology 2007: 75(4): pp 1698-1703.
infected children: a health-care team’s approach.
Program. Mupirocin-resistant, methicillin-resistant
Vulnerable Children and Youth Studies Journal 2007:
Staphylococcus aureus strains in Canadian hospitals.
2: pp 12-16.
Antimicrobial Agents Chemotherapy 2007: 51(11): pp
BOOKS AND BOOK CHAPTERS
3880-3886.
Allen U: Practice point: a pregnant patient with a previous
D, Willey BM, Gravel D, Bontovics E, Yaffe B, Katz K:
Sincitial (IRIS) Study Groups, Sampalis JS, Langley J,
disease. In: Infectious Diseases, 3rd Edition
(Armstrong D, Cohen J, eds.). Mosby, London, 2008.
Saunders A, Panaro L, McGeer A, Rosenthal A, White
pregnancy complicated by group B streptococcal
An outbreak of methicillin-resistant staphylococcus
Carbonell-Estrany X, Paes B, O’Brien K, Allen U,
aureus (MRSA) among healthy newborns and their
Mitchell I, Figueras Aloy J, Pedraz C, Michaliszyn AF:
mothers. Canadian Journal of Infectious Diseases
Development and validation of a risk scoring tool to
and Medical Microbiology 2007: 18: pp 128-132.
predict respiratory syncytial virus hospitalization in
tuberculosis. In: The Canadian Tuberculosis Standards,
premature infants born at 33 through 35 completed
6th Edition (Long R, Ellis E, eds.). Health Canada and
Schuh S, Lalani A, Allen U, Manson D, Babyn P,
weeks gestation. Medical Decision Making 2008:
the Canadian Lung Association, Ottawa, 2007.
Stephens D, MacPhee S, Mokanski M, Khaikin S,
28(4): pp 471-480.
Dick P: Evaluation of the utility of radiography in
Kitai IC, Malloy P, Kowalczyk A, Long R: Pediatric
Matlow A, Bohnen J: Improving patient safety through
acute bronchiolitis. Journal of Pediatrics 2007:150:
Tjon J, Lam W, Seto W, Dekker A, Wong C, Atenafu E,
pp 429-433.
Bitnun A, Waters V, Yau Y, Solomon M, Ratjen F:
informatics. In: Pediatric Informatics (Lehmann CU,
Pharmacokinetic modelling of once daily dosing
Kim GR, Johnson KB, eds.). Springer, New York, 2008.
regimen for intravenous tobramycin in paediatric cystic
fibrosis patients. Journal of Antimicrobial
Chemotherapy 2007: 59: pp 1135-1140.
100 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
standardization of care and beyond: the role of
Rosenthal A, Samson L: Bacterial meningitis.
A pilot study of genetic determinants of severe
Genetic determinants of influenza severity in children:
In: Therapeutic Choices, 5th Edition. Canadian
influenza in children. Tran D, Paterson A, Beyene J,
a pre-pandemic community-based feasibility study.
Pharmacists Association, Ottawa, 2007.
Schuh S, Richardson S. Dean’s Fund New Staff Grant,
Tran D, Beyene J, Bitnun A, Ipp M, Paterson A,
University of Toronto ($10,000 2007-2008)
Richardson SE. Canadian Institutes of Health
FUNDING
Research ($99,919 2008-2009)
A multicentre, double-blind, randomized, placebo-
A study of an HPV VLP vaccine in a cohort of HIV
controlled, dose-ranging trial evaluating the safety
positive girls and women. Louch D, Bitnun A, Dobson
Heart failure and the Coxsackie-Adenovirus Receptor
and efficacy of RI-001 (RespImmune/RSV-IVIG) in
S, Kollmann T, Ogilvie G, Raboud J, Stuart G, Wobeser
(CAR): insights through a novel heart targeted CAR
respiratory syncytial virus (RSV) infected patients at
W, Cote H, Forbes J, Krajden M, Petric M, Rachlis A,
transgenic mouse. Opavsky A. Heart and Stroke
risk of severe RSV illness. Allen U and ADMA 001
Coutlee F, Klein M, Loutfy M, Pick N, Smaill F,
Foundation of Ontario ($278,151 2007-2010)
Study Group (Allen U, PI for international study).
Walmsley S. Canadian Institutes of Health Research
ADMA Biologics (US$45,000 estimate based on
($646,068 2008-2010)
hypertriglyceridemia in HIV-infected children taking
$9,000 per patient enrolled - estimated $500,000
2007-2008 internationally)
A pharmacokinetic/pharmacodynamic and safety
Effect of omega-3 fatty acid supplementation on
Defining the role of Stenotrophomonas maltophilia in
highly active antiretroviral therapy (HAART): a
CF patients. Waters V, Yau Y. Bickell Foundation
randomized cross-over study. Read S, Bitnun A,
($64,976 2007)
Brophy J. Physicians Services Incorporated
Foundation ($32,000 2007-2009)
evaluation of oseltamivir for the treatment of children
less than 24 months of age with confirmed influenza
Defining the role of Stenotrophomonas maltophilia in
infection (CASG 114). Allen U (lead at SickKids site).
CF patients. Waters V, Yau Y. SickKids Summer
Division of Microbiology and Infectious Diseases,
Research Program ($2,000 2007)
National Institutes of Health (US$42,500 based on
five patients enrolled at $8,500 per patient)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 101
Effect of omega-3 fatty acid supplementation on
Impact of oximetry on disposition in acute bronchiolitis.
Mitochondrial DNA damage in infants exposed to HIV
hypertriglyceridemia in HIV-infected children taking
Schuh S, Freedman S, Coates A, Parkin P, Allen U,
antiretroviral drugs in utero. Cote H, Forbes J, Money
highly active antiretroviral therapy (HAART): a
Willan A, Ungar W, DaSilva Z. Physicians Services
D, Burdge D, Harrigan R, Bitnun A, Read S. Canadian
randomized cross-over study. Bitnun A, Read S,
Incorporated Foundation ($163,000 2007-2009)
Institutes of Health Research ($279,414 2006-2008)
Research ($25,000 2007-2009)
Impact of oximetry on disposition in acute
MRSA special innovation award. Barton-Forbes M
bronchiolitis. Coates A, Parkin P, Allen U, Willan A,
(Allen U, Bayoumi A, supervisors). Infectious
Epstein-Barr virus in health and disease in children
Ungar W, Da Silva Z. Thrasher Foundation
Diseases Society of America ($20,000 2008)
and youth: a prospective study of markers of
($125,000 2007-2010)
Brophy J. Canadian Foundation for HIV/AIDS
Predicting the risk of infection in children receiving
virus-host interaction and genetic variation. Allen U
(lead Principal Investigator), Beyene J, Mazzulli T,
Measuring the quality of hospital care of children and
chemotherapy for acute myeloid leukaemia. Allen U,
Robinson J, Read S, Grunebaum E, Zielsenska M,
youth in Canada. Guttmann A, Anderson GM, Matlow
Beyene J. National Cancer Institute of Canada
Tellier R, Weitzman S. Canadian Institutes of Health
AG, Parshuram C, To T. Canadian Institute of Health
($817,963, 2008-2012)
Research ($397,968 2008-2012)
Research/Ministry of Health and Long-Term Care
(CIHR $25,000 per year for three years and MOHLTC
Immunogenicity of the 7-valent conjugate
$100,000 per year for three years 2008-2011)
Predicting the risk of infection in children receiving
chemotherapy for acute myeloid leukaemia. Sung L,
pneumococcal vaccine in HIV-infected children. Bitnun
Allen U, Beyene J. Canadian Institutes of Health
A, Alllen U, Read S. Physicians Services Incorporated
Research ($582,104 2008-2012)
Foundation ($16,000 2007-2008)
102 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Prospective cohort study of genetic variation and
Use of interferon gamma release assays in children.
Randomized double-blind controlled trial of the use of
risk of infection in Canadian children with primary
Kitai I. The Hospital for Sick Children Paediatric
a biofilm antimicrobial susceptibility assay to guide
acute myeloid leukaemia. Sung L, Beyene J, Allen U.
Consultants Partnership’s Grant ($8,400 2007-2009)
antibiotic therapy in chronic Pseudomonas aeruginosa
Severe influenza in children: genetic determinants and
Ratjen F, Tullis E, Corey M. Innovotech Inc.
related epidemiology. Tran D, Beyene J, Paterson A,
($200,000 2008-2011)
infected cystic fibrosis patients. Waters V, Yau Y,
National Cancer Institute of Canada
($444,424 2005-2008)
Retrospective study of caspofungin in organ transplant
Richardson, Schuh S. SickKids Foundation
recipients. Allen U. Merck Canada ($21,000 2008)
($129,893 2008 2010)
What makes an excellent clinician in an academic
health sciences centre? Mahant S, Wadhwa A. The
RSV infection among transplant recipients and other
Hospital for Sick Children Paediatric Consultants
high-risk populations. Allen U, Robinson J. Abbott
Partnership’s Grant ($8,300 2007)
Canada ($236,000 2008-2010)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 103
Dr. Hilary Whyte
DIVISION HEAD
Dr. Keith Tanswell
FULL-TIME
Dr. Jacques Belik
Dr. Jonathan Hellmann
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Andrew James
Kyong-Soon Lee
Patrick McNamara
Aideen Moore
Christopher Tomlinson
Hilary Whyte
PART-TIME
Dr. Rosemary Moodie
ADJUNCT
Dr. Xiaoping Luo
CROSS-APPOINTEES
Dr. Bonnie Stevens
SCIENTIFIC STAFF
Dr. Virginia Frisk
HONORARY FACULTY
Dr. Max Perlman
Dr.Paul Swyer
MOUNT SINAI HOSPITAL
Dr. Olufunmi Akindele
Dr. Yenge Diambomba
Dr. Ann Jefferies
Dr. Edmond Kelly
Division of Neonatology
OVERVIEW
The division’s Neonatal-Perinatal Fellowship Training
PUBLICATIONS
The Division of Neonatology welcomes Dr. Christopher
Program continues to train the largest number of
Abrahamyan L, Johnson SR, Beyene J, Shah PS,
Tomlinson to the faculty at The Hospital for Sick
subspecialty trainees in Neonatology of any centre in
Feldman BM: Quality of randomized controlled trials in
Children and Dr. Maggie Shu to the faculty at
Canada, under the leadership of the program director,
juvenile idiopathic arthritis. Journal of Rheumatology
Mount Sinai Hospital.
Dr. Martin Skidmore.
2008: 47: pp 640-645.
The three level III NICUs at The Hospital for Sick
The division continues to be well supported by major
Alfaleh K, Smyth JA, Roberts RS, Solimano A, Asztalos
Children, Mount Sinai Hospital and at Women’s
funding agencies for its various foci at the three sites,
EV, Schmidt B: Prevention and 18-month outcomes of
College Hospital continue to suffer from a shortage
including lung biology, epidemiology, outcomes-based
serious pulmonary hemorrhage in extremely low birth
of sufficient level III NICU beds to adequately meet the
research and clinical trials.
weight infants: results from the trial of indomethacin
maternal and neonatal needs of our catchment area,
prophylaxis in preterms. Pediatrics 2008: 121(2):
which has continued to result in regrettable deferrals
HONOURS AND AWARDS
of patients out of region, province and country. The
Jefferies A: Canadian Association for Medical
Ministry of Health and Long-Term Care commissioned
Education/Certificate of Merit, 2007.
pp e233-e238.
a Neonatology Task Force, with province-wide
Asztalos E: The need to go beyond: evaluating
antenatal corticosteroid trials with long term
representation including representatives from the
McNamara P: Award for Teaching Excellence 2007-
outcomes. Journal of Obstetrics and Gynaecology
three Toronto NICUs, to address the issue of current
2008, Neonatal-Perinatal Medicine Training Program,
Canada 2007: 29(5): pp 429-432.
level III NICU bed requirements across the province,
University of Toronto, 2008.
and the predicted increase in requirements over the
Aziz A, Ohlsson A: Surfactant for pulmonary
next 10 to 15 years. This was delivered in 2007, and
Ng E: The Jonathan Tolkin Teaching Award, North York
hemorrhage in neonates. Cochrane Database
an announcement from the Ministry of Health and
General Hospital, 2007.
Systematic Review 2008: 2: CD005254.
Whyte H: Paediatric Emergency Medicine Teaching
Azrapoozah A, Lawrence H, Limeback H, Shah PS:
Award, part-time staff, June 2008.
Xylitol for preventing acute otitis media in children
Long-Term Care is expected in June or July, 2008.
up to 12 years of age (protocol). Cochrane Database
of Systematic Reviews 2008: 2: CD007095.
Dr. Karel O’Brien
Dr. Arne Ohlsson
Dr. Prakesh Shah
Dr. Vibhuti Shah
Dr. Maggie Shu
Dr. Sharon Unger
Dr. Kin Fan Young Tai
ST. MICHAEL’S HOSPITAL
Dr. Tony Barozzino
Dr. Douglas Campbell
Dr. Michael Sgro
SUNNYBROOK HEALTH
SCIENCES CENTRE
FULL-TIME
Dr. Elizabeth Asztalos
Dr. Michael Dunn
Dr. Robert Jankov
Dr. Andrew Shennan
Dr. Brian Simmons
Dr. Martin Skidmore
Dr. Adrian Ziino
PART-TIME
Dr. Shaheen Doctor
Dr. Eugene Ng
CLINICAL FELLOWS
Dr. Suhair Al-Shanteer
Dr. Lucia Aliwalas
Dr. Haydi Alwassia
Dr. Ijaz Aman
Dr. Taiba Balkhair
Dr. Rudaina Banihani
Dr. Joanne Beamish
Dr. Donna Capili
Dr. Guo Qiang Cheng
Dr. Roxana Conti
Dr. Blondel Crosdale
Beck J, Brander L, Slutsky AS, Reilly MC, Dunn MS,
Berry MA, Shah PS, Brouillette RT, Hellmann J:
Finan E, Mak W, Bismilla Z, McNamara PJ: Early
Sinderby C: Non-invasive neurally adjusted ventilatory
Predictors of mortality and length of stay for neonates
discontinuation of intravenous prostaglandin E (1)
assist in rabbits with acute lung injury. Intensive Care
admitted to children’s hospital neonatal intensive
after balloon atrial septostomy is associated with an
Medicine 2007: 34: pp 316-323.
care units. Journal of Perinatology 2008: 28(4):
increased risk of rebound hypoxemia. Journal of
pp 297-302.
Perinatology 2008: 28(5): pp 341-346.
Belik J, Shehnaz D, Pan J, Grasemann H:
Developmental changes in arginase expression and
Bishara R, Dunn MS, Merko SE, Darling P: Nutrient
Fornaro E, Li D, Pan J, Belik J: Prenatal exposure to
activity in the lung. American Journal of Physiology -
composition of hindmilk produced by mothers of very
fluoxetine induces fetal pulmonary hypertension in the
Lung Cellular and Molecular Physiology 2008: 294:
low birth weight infants born at less than 28 weeks
rat. American Journal of Respiratory and Critical Care
pp L498-L504.
gestation. Journal of Human Lactation 2008: 24(2):
Medicine 2007: 176(10): pp 1035-1040.
pp 159-167.
Gibbins S, Stevens B, Beyene J, Chan PC, Bagg M,
Berry MA, Shah PS, Brouillette RT, Hellmann J:
Asztalos E: Pain behaviours in extremely low
Determinants of mortality and length of stay for
El Shahed AI, Dargaville P, Ohlsson A, Soll RF:
neonates admitted to children’s hospital neonatal
Surfactant for meconium aspiration syndrome in
gestational age infants. Early Human Development
intensive care units. Journal of Perinatology 2008:
full-term/near-term infants. Cochrane Database
2008: 84(7): pp 451-458.
28: pp 297-302.
Systematic Review 2007: 3: CD002054.
Gibbins S, Stevens B, McGrath P, Yamada J, Beyene J,
Camfield C, Finley A, Franck L, Johnston C, O’Brien K,
Ohlsson A: Comparison of pain responses in infants of
different gestational ages. Neonatology 2007: 93(1):
pp 10-18.
Dr. Christopher Tomlinson
Hamada S, Vearncombe M, McGeer A, Shah PS:
Neonatal group B streptococcal disease: incidence,
presentation, and mortality. Journal of Maternal, Fetal,
and Neonatal Medicine 2008: 2(1): pp 53-57.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Walid El-Naggar
Manal El Sayed
Emer Finan
Claudia Garcia Gelvez
David Gryn
Wenxiang Guo
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Omer Hamud
Doriana Kriguer
Ana Teresa Leslie
Jillian Lewis
Patricia Lewis
Linh Ly
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Pat Mateo
Ashok Mittal
Adel Mohamed
Marcelo Panzenhagen
Shilpa Saxena
Sandesh Shivananda
Dr.
Dr.
Dr.
Dr.
Dr.
Hanifi Soylu
Christopher Tomlinson
Connie Williams
Man Yi
Jennifer Young
RESEARCH FELLOWS
Dr. Ben Hur Johnson
Dr. Mandy Lau
Dr. Azhar Masoud
ADMINISTRATIVE STAFF
Sonia Dos Santos
Violeta Dukic
Ana Granic
Jewel Randolph
James AG, Kent A: Spackman. Representation of
Jankov RP, Kantores C, Pan J, Belik J: Contribution of
Koenen SV, Dunn EA, Kingdom JC, Ohlsson A, Matthews
disorders of the newborn infant by SNOMED CTВ®.
xanthine oxidase-derived superoxide to chronic
SG: Overexposure to antenatal corticosteroids: a global
Studies in Health Technology and Informatics 2008:
hypoxic pulmonary hypertension in neonatal rats.
concern. Journal of Obstetrics and Gynaecology Canada
136: pp 833-838.
American Journal of Physiology - Lung Cellular and
2007: 29(11): p 879.
Molecular Physiology 2008: 294: pp L233-L245.
Kornecki A, Engelberts D, McNamara PJ, Jankov RP,
James AG: Benefits of early childhood interventions
last well into adulthood. AboutKidsHealth 2007:
Jefferies A, Simmons B, Regehr G: The effect of
McCaul C, Ackerly C, Post M, Kavanagh BP: Vascular
October 5. www.aboutkidshealth.ca/News/
candidate familiarity on examiner OSCE scores.
remodelling alters ventilator-induced lung injury.
Benefits-of-early-childhood-interventions-last-
Medical Education 2007: 41(9): pp 888-891.
Anesthesiology 2008: 108(6): pp 1047-1054.
Jefferies A, Simmons B, Tabak D, McIlroy JH, Lee K-S,
Lausman AY, Langer JC, Tai M, Seaward PGR, Windrim
Roukema H, Skidmore M: Using an objective
RC, Kelly EN, Ryan G: Gastroschisis: what is the
well-into-adulthood.aspx?articleID=10404&
categoryID=news-poh4
James AG: Folic acid supplementation and pre-
structured clinical examination (OSCE) to assess
average gestational age of spontaneous delivery?
eclampsia. AboutKidsHealth 2008: February 14.
multiple physician competencies in postgraduate
Journal of Pediatric Surgery 2007: 42(11): pp
www.aboutkidshealth.ca/News/Folic-acid-
training–the CanMEDS roles. Medical Teacher 2007:
1816-1821.
supplementation-and-pre-eclampsia.aspx?
29(2-3): pp 183-191.
Lee SH, Tomlinson C, Temple M, Amaral J, Connolly
articleID=10722&categoryID=news-poh1
Kabra NS, Schmidt B, Roberts RS, Doyle LW, Papile L,
BL: Imaging-guided percutaneous needle aspiration or
James AG: Folic acid supplementation reduces neural
Fanaroff A. Trial of Indomethacin Prophylaxis in
catheter drainage of neonatal liver abscesses: 14-year
tube defects in Canada. AboutKidsHealth 2007:
Preterms Investigators (including Asztalos E):
experience. American Journal of Roentgenology 2008:
October 26. www.aboutkidshealth.ca/News/Folic-
Neurosensory impairment after surgical closure of
190(3): pp 616-622.
acid-supplementation-reduces-neural-tube-defects-in-
patent ductus arteriosus in extremely low birth weight
Canada.aspx?articleID=10428&categoryID=news-poh1
infants: results from the Trial of Indomethacin
Lodha A, Furlan AD, Whyte H, Moore AM: Prophylactic
Prophylaxis in Preterms. Journal of Pediatrics 2007:
antibiotics in the prevention of catheter-associated
James AG: Performance and behavioural outcomes
150(3): pp 229-234.
bloodstream bacterial infection in preterm neonates:
for children with congenital heart conditions.
a systematic review. Journal of Perinatology 2008:
AboutKidsHealth 2007: July 19. www.aboutkidshealth.
April 10 [Epub ahead of print].
ca/News/Performance-and-behavioural-outcomesfor-children-with-congenital-heart-conditions.aspx?
articleID=10283&categoryID=news-poh1
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 107
McNamara PJ, Teixiera L, Whyte H, Ly L: The
Lodha A, Kamaluddeen MS, Kelly E, Amin H:
McDevitt H, Tomlinson C, White MP, Ahmed SF:
Clostridium difficile infection precipitating hemolysis in
Changes in quantitative ultrasound in infants born
hemodynamically significant dustus arterious in
glucose-6-phosphate dehydrogenase deficient preterm
at less than 32 weeks gestation over the first two
critically ill full-term neonates. Fact or fiction?
twins causing severe neonatal jaundice. Journal of
years of life: influence of clinical and biochemical
Biology of the Neonate 2007: 107(1): pp 180-181.
Perinatology 2008: 28(1): pp 77-87.
changes. Calcified Tissue International 2007: 81(4):
pp 263-9.
McNamara PJ: Cardiopulmonary resuscitation for
A, Helewa M, Hewson S, Kavuma E, Lee SK, Logan AG,
McNamara P: Non-conventional use of amplitude
2008: May 26 [Epub ahead of print].
McKay D, Moutquin J-M, Ohlsson A, Rey E, Ross S,
integrated electroencephalography (aEEG): lessons from
Singer J, Willan AR, Hannah ME: Women’s views of
a tertiary NICU. Neonatology Today 2007: 2(1): pp 1-9.
neonates: evidence for compressions? Resuscitation
Magee LA, von Dadelszen P, Chan S, Gafni A, Gruslin
hypertension in pregnancy study) pilot trial.
Hypertension in Pregnancy 2007: 26(4): pp 371-387.
Morag I, Ohlsson A: Cycled light in the intensive care
unit for preterm/low birth weight infants (protocol).
their experiences in the CHIPS (control of
McNamara PJ, Al-Nabhani D, Finelli M:
Cochrane Database Systematic Review 2008:1:
Endo-tracheal tube with end-tidal carbon
CD006982.
dioxide port. Anesthesiology 2008: 108: p 337.
Nash A, Secker D, Corey M, Dunn M, O’Connor DL:
Malviya M, Ohlsson A, Shah S: Surgical versus
medical treatment with cyclooxygenase inhibitors
McNamara PJ, Murthy P, Kantores C, Teixeira L,
Field testing of the 2006 World Health Organization
for symptomatic patent ductus arteriosus in preterm
Engelberts D, Van Vliet T, Kavanagh BP, Jankov RP:
growth charts from birth to two years: assessment of
infants. Cochrane Database Systematic Review
Acute vasodilator effect of Rho-kinase inhibitors
hospital undernutrition and overnutrition rates and the
in neonatal rats with pulmonary hypertension
usefulness of BMI. Journal of Parenteral and Enteral
unresponsive to inhaled nitric oxide. American
Nutrition 2008: 32: pp 145-153.
2008: 1: CD003951.
McAuliffe F, Chitayat D, Halliday W, Keating S,
Journal of Physiology - Lung Cellular and Molecular
Shah V, Fink M, Nevo O, Ryan G, Shannon P, Blaser S:
Physiology 2007: 294: pp L205-L213.
autopsy findings. Ultrasound Obstetrics &
Gynaecology 2008: 31(5): pp 542-548.
O’Connor DI, Khan S, Weishun K, Jeffries A, Campbell
DM, Asztalos E, Feldman M, Rovet J, Westall C, Whyte H,
Rhombencephalosynapsis: prenatal imaging and
McNamara PJ, Sehgal AS: Towards rationale
Postdischarge Feeding Study Group: Growth and
management of the patent ductus arteriosus: the
nutrient intakes of human milk-fed preterm infants
need for disease staging. Archives of Disease in
provided with extra energy and nutrients after hospital
Childhood - Fetal and Neonatal Edition 2007: 92(6):
discharge. Pediatrics 2008: 121(4): pp 766-776.
pp F424-F427.
108 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Ohlsson A, Walia R, Shah S: Ibuprofen for the
Shah P, Ohlsson A, Perlman M: Hypothermia to treat
Shah PS, Shah N: Heparin bonded catheters for
treatment of patent ductus arteriosus in preterm and/
neonatal hypoxic ischemic encephalopathy. Archives
prolonging the patency of central venous catheters
or low birth weight infants. Cochrane Database
of Pediatrics and Adolescent Medicine 2007: 161:
in children. Cochrane Database of Systematic
Systematic Review 2008: 1: CD003481.
pp 951-958.
Reviews 2007: 4: CD005983.
Padela S, Yi M, Cabacungan J, Shek S, Belcastro R,
Shah P, Ohlsson A, Shah J: Continuous negative
Shah PS, Shah VS: Continuous heparin infusion
Masood A, Jankov RP, Tanswell AK: A critical role for
extrathoracic pressure or continuous positive airway
to prevent thrombosis and catheter occlusion in
fibroblast growth factor-7 during early alveolar
pressure for acute hypoxemic respiratory failure to
neonates with peripherally placed percutaneous
formation in the neonatal rat. Pediatric Research
children. Cochrane Database Systematic Review
central venous catheters. Cochrane Database
2008: 63: pp 232-238.
2008: 1: CD003699.
Systematic Review 2008: 2: CD002772.
Perlman M, Shah PS: Time to adopt cooling for
Shah P, Ohlsson A: Sildenafil for pulmonary
Shah S, Ohlsson A, Halliday H, Shah V: Inhaled versus
neonatal HIE: a response to previous commentary.
hypertension in neonates. Cochrane Database
systemic corticosteroids for the treatment of chronic
Pediatrics 2008: 121: pp 616-618.
Systematic Review 2007: 3: CD005494.
lung disease in ventilated very low birth weight
preterm infants. Cochrane Database Systematic
Review 2007: 4: CD002057.
Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington
Shah PS, Aliwalas L, Shah V: Breastfeeding or
KJ, Ohlsson A, Solimano A, Tin W, caffeine for apnea
breast milk to alleviate procedural pain in neonates:
of prematurity trial group (including Asztalos E):
a systematic review. Breastfeeding and Medicine
Shah V, Hencock R, Shah PS, Ohlsson A, Taddio A:
Long-term effects of caffeine therapy for apnea of
2007: 2: pp 74-82.
Topical amethocaine gel 4% for intramuscular injection
357: pp 1893-1902.
Shah PS, Perlman M, Ohlsson A: Hypothermia to
Clinical Therapeutics 2008: 30: pp 166-173.
Seghal A, Cook V, Dunn M: Pericardial effusion
systematic review. Archives of Pediatrics and
Shah V, Ohlsson A, Halliday H, Dunn M: Early
associated with an appropriately placed umbilical
Adolescent Medicine 2007: 161: pp 951-958.
administration of inhaled corticosteroids for
in term neonates: a randomized controlled trial.
prematurity. New England Journal of Medicine 2007:
treat neonatal hypoxic-ischemic encephalopathy:
venous catheter. Journal of Perinatology 2007:
27: pp 317-319.
preventing chronic lung disease in ventilated very
low birth weight preterm neonates. Cochrane
Database Systematic Review 2007: 4: CD001969.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 109
Shah V, Ohlsson A: Venepuncture versus heel lance
Tessler R, Pan J, Fiori HH, Belik J: Human meconium
BOOKS AND BOOK CHAPTERS
for blood sampling in term neonates. Cochrane
has a pulmonary vascular and airway smooth muscle
Asztalos E: Follow-up of the high-risk infant. In
Database Systematic Review 2007: 4: CD001452.
relaxant effect. Pediatric Research 2008: March 19
Residents Handbook of Neonatology, 3rd Edition
[Epub ahead of print].
(Kirpalani HM, Moore A, Perlman M, eds.). BC Decker,
Shah V, Shah P: Promising new strategies
Hamilton, Ontario, 2007.
for bronchopulmonary dysplasia in infants.
Tessler R, Wu S, Fiori R, Macgowan CK, Belik J:
Pediatric Health 2008: 2(3): pp 315-331.
Sildenafil acutely reverses the hypoxic pulmonary
Belik, J: Susceptibility of the immature lung to oxidative
vasoconstrictor response of the newborn pig. Pediatric
and mechanical injury. In: Questions and Controversies
Research 2008: April 30 [Epub ahead of print].
in Neonatology Series: Pulmonary Volume (E. Bancalari,
Stevens B, Franck L, Gibbins S, McGrath P, Dupuis A,
Yamada J, Beyene J, Camfield C, Finley A, Johnston C,
ed.). Elsevier, Philadelphia, 2008.
O’Brien K, Ohlsson A: Determining the structure of
Wu J, Duan R, Cao H, Field D, Newham CM,
acute pain responses in vulnerable neonates. Canadian
Koehler DR, Zamel N, Pritchard MA, Hertzog P,
FUNDING
Journal of Nursing Research 2007: 39(2): pp 32-47.
Taddio A, Manley J, Potash L, Ipp M, Sgro M, Shah V:
Post M, Tanswell AK, Hu J: Regulation of epithelium-
Airway modulation of pulmonary vascular tone during
specific Ets-like factors Ese-1 and Ese-3 in airway
development and following pulmonary hypertension.
inflammation. Cell Research 2008: 18: pp 649-663.
Belik J. Canadian Institutes of Health Research
Routine immunization practices: use of topical
Operating Grant ($110,108 2004-2009)
anaesthetics and oral analgesics. Pediatrics 2007:
Yinon Y, Kelly EN, Ryan G: Fetal pleural effusions.
120: pp e637-e643.
Best practice and research. Clinical Obstetrics and
Gynaecology 2008: 22(1): pp 77-96.
Tallett S, Lingard L, Leslie K, Pirie J, Jefferies L,
Spero L, Schneider R, Hilliard R, Rosenfield J,
An integrated, shared data management application
for the Toronto Tri-Hospital Respiratory Syncyticial
Virus Prophylaxis (RSVP) Program. O’Brien K, Bracht
Zupancic JAF, Richardson DK, Horbar JD, Carpenter JH,
M, Barton P, James AG. Abbott Laboratories Limited
($50,000 2005-2007)
Hellmann J, Mian M, Hurley J: Measuring educational
Lee SK, Escobar GJ and the Vermont Oxford network
workload: a pilot study of paper-based and PDA tools.
SNAP pilot project participants: Revalidation of the
Medical Teacher 2008: 30(3): pp 296-301.
score for neonatal acute physiology in the Vermont
Oxford network. Pediatrics 2007: 119: pp 156-163.
110 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
CAP follow up at five years. Schmidt B, Roberts R,
Death in Canadian neonatal intensive care units
Efficacy and safety of targeting lower arterial oxygen
Barrington K, Ohlsson A, Solimano A, Davis P, Doyle L,
(NICUs): exploring the ethical determinants. Hellmann
saturations to reduce oxygen toxicity and oxidative
Tin W. Canadian Institutes of Health Research
J, Shah P, Lee SK. Canadian Institutes of Health
stress in very preterm infants: Canadian Oxygen Trial
($1,744,740 2005-2009)
Research ($99,698 2008-2010)
(COT). Schmidt B, Roberts R, Whyte R, Asztalos E,
Solimano A, Bairam, Chiu A, Clarke M, Harrold J, Kumar
CARESS: Canadian RSV evaluation study of SynagisВ®.
Delayed umbilical cord clamping in preterm infants:
M, Moddemann D, Peliowski A, Rabi Y, Roukema H,
Mitchell I, Paes B (Allen U, James AG, The Hospital for
a randomized controlled trial. Kelly C, Kellie M,
Sauve R, Seshia M, Shah PS. Canadian Institutes of
Sick Children site investigators). Abbott Laboratories
Whittle W, Windrim R, Shah PS. Mount Sinai
Health Research ($3,884,860 2006-2011)
Ltd. ($120 per patient enrolled 2007-2009)
Hospital ($4,000 2008)
CIHR Team in Maternal-Infant Care (MICare) grant. Lee
Early external cephalic version-2 trial. Hutton, EK,
in the regulation of pulmonary vascular tone during
SK, Ohlsson A, Shaw N, Liston R, Armson A, Aziz k,
Willan AR, Hannah ME, Gafni A, Ohlsson A, Barrett J,
development and following pulmonary hypertension. Belik
Endothelial eNOS uncoupling and role of BMP-9
Baker R, Saigal S, Skarsgard E, Hayward R, Dendukuri
Ross SJ, Windrim R, Delisle MF, Carson GD, Dunn MS,
J, Letarte M, Toporsian M, Jerkic M. Heart and Stroke
N, O’Campo P, Magee L, Sauve R, Stevens B, Joseph
Pollard JK, Natale R. Canadian Institutes of Health
Foundation Operating Grant ($86,906 2007-2009)
KS, Barrington K, El-Hajj M. Canadian Institutes of
Research ($2,853,717 2003-2007)
Evaluation of topical liposomal lidocaine and oral
Health Research ($4,924,135 2008-2012).
Early external cephalic version-2 trial. Hutton EK,
sucrose for treatment of pain in newborn infants
Conquering pain: the hidden cost of immunization. Taddio
Willan AR, Hannah ME, Gafni A, Ohlsson A, Barrett J,
undergoing venipuncture: a randomized controlled
A, Shah V, Ipp M, Chambers C, Halperin S,
Ross SJ, Windrim R, Delisle MF, Carson GD, Dunn MS,
trial. Taddio A, Shah V, Katz J, Stevens D, Koren G.
Lockett D. The Hospital for Sick Children ($5,000 2008)
Pollard JK, Natale R. Canadian Institutes of Health
Canadian Institutes of Health Research ($397,450
Research ($169,822 2008-2009)
2007-2009)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 111
External cephalic version-2 trials. Hutton E, Willan A,
Hypoglycemia and neuroplasticity in the neonatal
Low versus high fidelity simulation in neonatal
Hannah M, Gafni A, Ohlsson A, Barrett J, Ross S,
period. Shroff M, Moore A, Whyte H, Taylor M. The
resuscitation training. Finan E, Bismilla Z, Whyte HE,
Windrim R, Delisle M-F, Carson GD, Dunn M, Pollard
Department of Medical Imaging at University of
McNamara P, LeBlanc V. The Hospital for Sick
JK, Natale R, Sylvestre G. Canadian Institutes of
Toronto ($35,000 per year 2008-2010)
Children Paediatric Consultants Partnership’s
Education Research Grants ($5,000 2008-2009)
Health Research ($169,822 2008-2009)
Infant flow biphasic NCPAP versus infant flow NCPAP
Functional MR imaging for early detection and
for facilitation of extubation in infants less than
Multicentre randomized trial of HeLP (heat loss
physiologic characterization of inflammatory arthritis
1,250 grams: a randomized controlled trial.
prevention) in the delivery room. Vohra S, Reilly MC,
in a rabbit model. Doria SA, Belik J, Kassner A, Cheng
O’Brien K, Shah V, Campbell C. Physicians Services
Dunn M, Vincer M, Wiebe N, Zayack D, Wimmer J.
H-L, Crawley A, Yeung R, Tomlinson G, Gahunia H.
Incorporated Foundation ($73,000 2006-2008)
2006-2007)
Canadian Institutes of Health Research ($640,465
2004-2008)
RSNA Research and Education Foundation ($29,964
Inhibition of apoptosis as a major component of
chronic neonatal lung injury. Tanswell AK, Jankov RP.
Multiple courses of antenatal corticosteroids for
Genome-environment interactions in Type I diabetes.
Canadian Institutes of Heath Research ($477,180
preterm birth (MAC). Murphy K, Asztalos E. Canadian
Danska J, MacPherson A, Moore AM. Genome Canada
2005-2010)
Institutes of Health Research ($2,943,583 2006-2010)
($94,127 2005-2009)
INTAPP (International trial of antioxidants for the
Multiple courses of antenatal corticosteroids for
Group in lung development. Tanswell AK, Belik J,
prevention of pre-eclampsia). Fraser W, Xiong X,
preterm birth study: a five-year follow-up (MACS-5).
Chan A, O’Brodovich H, Post M, Rotin D, Cutz E,
Julien P, Thomas N, Magee LA, Ohlsson A. Canadian
Asztalos E, Gafni A, Hannah M, Murphy K, Ohlsson A,
Hu J, Kavanagh B, Otulakowski G, Yeger H. Canadian
Institutes of Health Research ($4,923,447 2002-
Ross S, Saigal S, Willan A, Matthews S, Rovet J,
Institutes of Health Research ($1,377,695 2004-2009).
2007)
Lee S, Amankwah K, Kelly EN, Lee SK, Delisle M-F,
Guselle P, Sananes R. Canadian Institutes of Health
Research ($3,585,161 2005-2012).
112 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Nasal ventilation in premature infants. Kirpalani H,
Novel therapeutic interventions for bronchopulmonary
Quality of care ICE (QC-ICE) team in neonatal-perinatal
Chiu A, Lemyre B, Millar D, Roberts R, Vaillancourt K,
dysplasia: Targeting oxidants and growth factors in the
care. Lee KS, Baker GR, Langley JM, MacNab YC,
Alvaro R, Connelly R, Howlett A, McNamara P,
newborn rat lung. Jankov RP. Canada Foundation for
Moehr JR, Ohlsson A, Stevens B, Magee L, Sauve R,
Peliowski A, Solimano A, Shah P, Aziz K, Zupancic J,
Innovation New Opportunities Fund/Ontario
Keller P, Michalos A, Klassen A. Canadian Institutes
Meade M. Canadian Institutes of Health Research
Research Fund ($297,340 2004-2009)
of Health Research ($935,000 2003-2007)
Observational study on the effects of enteral feeding
Randomized study of vasopressin versus epinephrine
($2,233,100 2006-2009)
National health partnership for reducing infections in
and feeding methods on respiratory pattern as
in a neonatal model of asphyxial cardiac arrest.
NICU. Lee SK, Aziz K, Baker GR, Barrington K, Clarke
assessed by diaphragm electrical activity (EAdi) in
McNamara PJ, Kavanagh BP. American Academy of
MCW, Cronin CM, Dunn MS, James AG, Langley J, Lee
very low birth weight (VLBW) preterm infants. Ng E,
Pediatrics, Neonatal Resuscitation Grant ($28,752
DS, Lefebvre F, Merchant P, Ohlsson A, Orrbine E,
Schurr P, Reilly M, Dunn M, Beck J. Physician Services
2006-2008)
Peliowski A, Sankaran K, Seshia M, Shaw NT, Synnes
Incorporated Foundation ($26,000 2008-2009)
Reactive nitrogen species and smooth muscle growth
AR, Tan-Dy CR, Walker CR, Whyte RK. Canadian
Institutes of Health Research Canadian Neonatal
Pharmacology of milrinone in persistent pulmonary
regulators in the pathogenesis of newborn pulmonary
Network ($99,999 2005-2008)
hypertension of the newborn. McNamara P, Taddio A.
hypertension. Jankov RP. Career Development Award,
The Hospital for Sick Children New Ideas Grant
Canadian Child Health Clinician Scientist Program/
Neuroimaging measures of brain function in preterm
($39,349 2006-2008)
Canadian Institutes of Health Research ($280,000
2004-2008)
neonates. Taylor M, Whyte H, Moore A, McNamara P,
Donner E, Sharoff M. Collaborative Health Research
Predicting neurobehaviourial outcome in preterm
Program ($361,860 2008-2011)
neonates. Taylor M, Whyte HE, Moore A, Shroff M,
Regulation of normal and oxygen-mediated aberrant
Rayboud C, Donner E, Frisk V. Canadian Institutes of
postnatal lung growth by growth factors. Tanswell AK.
Health Research ($929,910 2007-2012)
Canadian Institutes of Health Research ($799,686
2005-2010)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 113
Rho-kinase inhibitor as therapy for chronic neonatal
Strategic training initiative in research in reproductive
Systematic reviews of determinants and effectiveness
pulmonary hypertension. Jankov RP. Canadian
health sciences. Fraser WD, Campbell M, Collet J,
of primary preventive interventions for low birth weight
Institutes of Health Research New Investigator
Davidge S, De Koninck M, Dodds L, Dodin S, Fisher W,
and preterm birth. Shah P, Ohlsson A, Shah V, Murphy
Award ($300,000 2008-2013)
Rho-kinase inhibitor as therapy for chronic neonatal
Gagnon R, Grant A, Hatem-Asmar M, Heaman M,
K, Hutton E, Beyene J, Frick C, Allen V, McDonald S,
Joseph K, Klein M, Labrecque M, Lambert R, Lee S,
Newburn-Cook C, Scott F. Canadian Institutes of
Letourneau L, Leung P, Lye S, McCoshen J, Moutquin J,
Health Research ($100,000 2008)
pulmonary hypertension. Jankov RP, McNamara PJ.
Nisker J, Ohlsson A, Pierson R, Sauve R, Smith G, Von
Canadian Institutes of Health Research Operating
Dadelszen P, Walker M, Wood S. Canadian Institutes
Teaching neonatal intubations to residents: standard
Grant ($323,592 2007-2010)
of Health Research ($1,800,000 2002-2008)
mannequin versus high fidelity simulation. Finan E,
Role of peroxynitrite and macrophages in newborn
Surveillance of kernicterus in Canada. Sgro M,
pulmonary vascular remodelling. Jankov RP. Canadian
Campbell D, Shah V. Canadian Medical Protection
Institutes of Health Research ($285,888 2005-2008)
Association ($44,660 2007-2008)
Role of reactive oxygen/nitrogen species in normal
Surveillance of Kernicterus in Canada. Sgro M,
Institutes of Health Research Group Grant
and aberrant postnatal lung growth. Tanswell AK.
Campbell D, Shah V. Ontario Federation for
($1,285,443 2004-2009)
Canadian Institutes of Health Research ($708,400
Cerebral Palsy ($25,100 2007-2008)
Bismilla Z, Whyte HE, V LeBlanc. Physicians Services
Incorporated Foundation ($17,000 2007-2008)
The developing lung: cellular and molecular physiology.
Tanswell AK. Medical Research Council/Canadian
The twin birth study: a multicentre randomized
2004-2009)
Survey of mode of delivery and maternal and perinatal
controlled trial comparing planned caesarean section
Safety and efficacy of methylxanthines in the very
outcomes in Canada. Lee S, Armson A, Allen V,
with planned vaginal birth for twins at 32 to 38 weeks
low birth weight infant: five-year follow-up. Schmidt B,
Andruschuk J, Attenborough R, Bottomley J, DaSilva O,
gestation. Barrett J, Hannah M, Willan A, Ross S,
Asztalos E. Canadian Institutes of Health Research
Frick C, Heaman M, Murphy P, Pasquier J-C, Bujold E,
Hutton E, Allen A, Joseph KS, Armson A, Farrell S,
($1,744,740 2004-2009).
Crane J, Dumont A, Janssen P, Klein M, Liu S,
Ohlsson A, Asztalos E, Gafni A, Okun N, Leduc L.
Moutquin J-M, O’Brien B, Ohlsson A, Platt R, Sauve R,
Canadian Institutes of Health Research ($8,608,045
von Dadelszen P, Walker M. Canadian Institutes of
2003-2011)
Health Research/World Health Organization
($250,000 2007-2009)
114 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Thyroid hormone insufficiencies and visual perception
Utility of modern ultrasound in the evaluation of
What is it like for NICU nurses to care for newborns at
deficits in preterm infants. Rovet J, Asztalos E, Westall
cerebral venous sinuses in neonates. Miller E, Shroff
the end of their lives? Lindsay G, Ives-Baine LA, Cross
C, Heon E. March of Dimes ($253,083 2004-2007)
M, Moore AM. Physicians Services Incorporated
N, Hellmann J. University of Ontario Institute of
Foundation ($35,500 2007-2009).
Technology ($17,850 2007-2008)
Asztalos E, Gibbins S, McKeever P, Pillai-Riddell A.
Vasopressin in paediatric shock. Choong K, Bohn D,
Withdrawal of artificial hydration and nutrition in
Canadian Institutes of Health Research ($77,921
Joffe A, Menum K, McNamara P, Litalien C. Canadian
newborn infants: determining neonatal nurses’
2005-2008)
Institutes of Health Research ($136,792 2006-2007)
perspectives on the ethical and practical issues in
Understanding chronic pain in infancy. Stevens B,
this practice. Hellmann J, Ives-Baine L, Golec L,
Lindsay G, Lee KS, Stephens D, Hetherington R. The
Using telemedicine strategies to prevent avoidable
Vasopressin in paediatric shock. Choong K, Bohn D,
blindness in retinopathy of prematurity: reliability and
Joffe A, Menum K, McNamara P, Litalien C. Heart and
Hospital for Sick Children Paediatric Consultants
measures of pain. Tehrani N, Kertes P, Gibbins S,
Stroke Foundation of Canada ($61,623 2006-2007)
Partnership’s Grant for Creative Professional Activity
James A. EA Baker Foundation of the National
($10,000 2008-2009)
Institute of the Blind ($40,000 2006-2008)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 115
Division of
Dr. Tino Piscione
DIVISION HEAD
Dr. Denis F. Geary
FULL-TIME
Dr. Elizabeth A. Harvey
Dr. Diane HГ©bert
Dr.
Dr.
Dr.
Dr.
Dr.
Valerie Langlois
Christoph Licht
Tino D. Piscione
Lisa A. Robinson
Norman D. Rosenblum
PART-TIME
Dr. Marion Cummings
Dr. Rachel Pearl
ADJUNCT
Dr. Leo Levin
HONORARY
Dr. Gerald S. Arbus
CLINICAL FELLOWS
Dr. Thoraya Al Maslamani
Dr. Sudarsana De
Dr. Meeta Mallik
Dr. Rola Saqan
SUBSPECIALTY RESIDENTS
Dr. Naifain Al-Kalbani
Dr. Dana Al-Nabhani
Dr. Elizabeth Berger
Dr. Mathieu Lemaire
Dr. Seetha Radhakrishnan
Dr. Lindsay Teskey
Division of Nephrology
OVERVIEW
Dr. Christoph Licht continued to expand his reputation
Rosenblum, ND: Canada Research Chair in
This has been a very successful year for the
as a leader in the field of complement related renal
Developmental Nephrology (Tier I), 2005-present.
Nephrology Division.
disorders, and was appointed as a member of two
international working groups within this field. He
Rosenblum ND: Selected as Best Doctors
The clinical work has remained intense, with ever
published a description of a new subgroup of Atypical
Physician, 2007.
increasing patient complexity and volumes.
Hemolytic Uremic Syndrome.
The division has been ably represented by Drs.
In recognition of her expertise as an educator,
Akikusa JD, Schneider R, Harvey EA, Hebert D,
Hebert, Robinson and Langlois in the development
Dr. Elizabeth Harvey was appointed an examiner
Thorner PS, Laxer RM, Silverman ED: Clinical features
of the SickKids Transplant Centre, and integration
for the Royal College of Physicians of Canada. Also,
and outcome of pediatric Wegener’s granulomatosis.
of Nephrology within that administrative structure.
within the educational arena, Dr. Aoife Waters was
Arthritis and Rheumatism 2007: 57: pp 837-844.
Dr. Piscione, together with the leadership of the
chosen to represent the Department of Paediatrics
Molecular Genetics laboratory, was instrumental in the
at the National Paediatric Residents and Fellows
Bridgewater D, Cox B, Cain J, Lau A, Althaide V,
development of clinically approved testing for genetic
Research Competition.
Gill P, Kuure S, Sainio K, Rosenblum ND. Canonical
PUBLICATIONS
abnormalities in children with Nephrotic Syndrome.
WNT/b-catenin signalling is required for ureteric
Dr. Norman Rosenblum served as Associate Editor
branching. Developmental Biology 2008: 317(1):
The three scientists in the division, Drs. Norman
(Renal and Urinary Tract Section) for Rudolph’s Textbook
pp 83-94.
Rosenblum, Lisa Robinson and Tino Piscione, have
of Paediatrics and Dr. Denis Geary edited the first
all been successful in their applications for research
edition of Comprehensive Pediatric Nephrology.
Cain JE, Hartwig S, Bertram JF, Rosenblum ND.
manuscripts in highly rated journals. Dr. Robinson’s
HONOURS AND AWARDS
and future. Differentiation 2008: March 7
role in the development of the Kids Science program
Licht C: Appointed Member of the European
[Epub ahead of print].
was recognized by a special Synapse Award from
Paediatric Research Group for HUS, 2007.
grant funding, and have published a variety of
BMP signalling in the developing kidney: present
CIHR, and Dr. Rosenblum was named Director of the
Collins K, Roberts E, Adeli K, Bohn D, Harvey E:
Clinician Scientist Training Programs in the Faculty of
Licht C: Appointed Associate Member of the
Single Pass Albumin Dialysis (SPAD) in fulminant
Medicine at U of T. Dr. Robinson was also promoted to
European Working Party for the Genetics of
wilsonian liver failure: a case report. Pediatric
Associate Professor in the Department of Paediatrics.
Complement Based Diseases, 2007.
Nephrology 2008: February 26 [Epub ahead of print].
RESEARCH FELLOW
Dr. Aoife Waters
ADMINISTRATIVE STAFF
Dana Debernyj
Juliet Rodrigo
Bernard Singh
Marisa Tuzi
Tania Viseu
POST-DOCTORAL FELLOWS
Dr. Darren Bridgewater
Dr. Jason Cain
Dr. Lijun Chi
Dr. Tuncer Onay
CLINICAL RESEARCH
ASSOCIATES
Michelle Frieling
Jun Chuan Teh
Durkan A, Alexander RT, Liu GY, Rui M, Femia G,
Hartwig S, Bridgewater D, Cain J, DiGiovanni V,
Licht C, Schlötzer-Schrehardt U, Kirschfink M,
Robinson LA: Expression and targeting of CX3CL1
Mishina Y, Rosenblum ND. The BMP receptor ALK3
Zipfel PF, Hoppe B: MPGN II–genetically determined by
(Fractalkine) in renal tubular epithelial cells. Journal of
controls collecting system formation during murine
defective complement regulation? Pediatric
kidney development. Journal of the American
Nephrology 2007: 22(1): pp 2-9.
the American Society of Nephrology 2007: 18: pp 74-83.
Society of Nephrology 2008: 19: pp. 117-124.
O’Brodovich H, Beyene J, Tallett S, MacGregor D,
Geary DF, Hothi D, Harvey EA, Goia C: Evaluating
methods for improving ultrafiltration in pediatric
Hiraki LT, Benseler SM, Tyrell PN, Hebert D, Harvey E,
Rosenblum ND: Performance of a career development
hemodialysis. Pediatric Nephrology 2008: 23(4):
Silverman ED: Clinical and laboratory characteristics
and compensation program at an academic health
pp 631-638.
and long-term outcome of pediatric systemic lupus
sciences centre. Pediatrics 2007: 119: pp e791-e797.
erythematosis: a longitudinal study. Journal of
Geary DF: Hemolytic uremic syndrome and streptococcus
Pediatrics 2008: 152(4): pp 550-556.
Pediatrics 2007: 151(2): pp 113-114.
Gerstung M, Roth T, Dienes H-P, Licht C, Fries JWU:
JГіzsi M, Licht C, Strobel S, Zipfel SLH, Richter H,
2006 Annual Report of the North American Pediatric
Heinen S, Zipfel PF, Skerka C: Factor H autoantibodies
Renal Trials and Collaborative Studies (NAPRTCS).
in atypical hemolytic uremic syndrome correlate
Pediatric Transplantation 2007: 11: pp 366-373.
Endothelin-1 induces NF-B via two independent
with CFHR1/CFHR3 deficiency. Blood 2008: 111(3):
pathways in human renal tubular epithelial cells.
pp 1512-1514.
Smith RJH, Alexander J, Barlow PN, Botto M,
Cassavant TL, Cook HT, de CГіrdoba SR, Hageman GS,
American Journal of Nephrology 2007: 27(3):
pp 294-300.
Smith JM, Stablein DM, Munoz R, Hebert D, McDonald
RA: Contributions of the Transplant Registry: the
pneumoniae: improving our understanding. Journal of
Koshy S, Geary DF: Anemia in children with chronic
Jokiranta TS, Kimberling WJ, Lambris JD, Lanning LD,
kidney disease. Pediatric Nephrology 2008: 23(2):
Levidiotis V, Licht C, Lutz HU, Meri S, Pickering MC,
pp 209-219.
Quigg RJ, Rops AL, Salant DJ, Sethi S, Thurman JM,
Tully HF, Tully SP, van der Vlag J, Walker PD, WГјrzner R,
Zipfel PF. Dense Deposit Disease Focus Group: new
approaches to the treatment of Dense Deposit
Disease. Journal of the American Society of
Nephrology 2007: 18(9): pp 2447-2456.
118 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Trapp M, Galtseva A, Manning D, Beier D,
BOOKS AND BOOK CHAPTERS
Langlois V: Laboratory evaluation at different ages.
Rosenblum ND, Quarmby L: Defects in ciliary
Cochat P, Hebert D: Demographics of pediatric
In: Comprehensive Pediatric Nephrology (Geary DG,
localization of Nek8 is associated with cystogenesis.
renal transplantation. In: Comprehensive Pediatric
Schaefer F, eds.). Elsevier Inc., Philadelphia, 2008.
Pediatric Nephrology 2008: 23: pp 377-387.
Nephrology (Geary DF, Schaefer F, eds.). Elsevier Inc.,
Licht C, Mengel M: Membranoproliferative
Philadelphia, 2008.
glomerulonephritis. In: Comprehensive Pediatric
Valentini RP, Geary DF, Chand D: Central venous
lines for chronic hemodialysis: survey of the
Durkan AM, Robinson LA: Acute allograft dysfunction.
Nephrology (Geary DF, Schaefer F, eds.). Elsevier Inc.,
Midwest Pediatric Nephrology Consortium.
In: Comprehensive Pediatric Nephrology (Geary DG,
Philadelphia, 2008.
Pediatric Nephrology 2008: 23(2): p 291.
Schaefer F, eds.). Elsevier Inc., Philadelphia, 2008.
Waters A, Langlois V, Thorner P, Geary D:
Geary DG, Schaefer F: Comprehensive Pediatric
development of the kidney: anatomic development of
Atypical p-ANCA is not a poor prognostic marker
Nephrology (Geary DF, Schaefer F, eds.). Elsevier Inc.,
the kidney. In: Comprehensive Pediatric Nephrology
in postinfectious glomerulonephritis. Pediatric
Philadelphia, 2008.
(Geary DG, Schaefer F, eds.). Elsevier Inc.,
Piscione TD, Waters AM: Structural and functional
Philadelphia, 2008.
Nephrology 2007: 22(9): pp 1383-1386.
Hothi D, Geary DF: Pediatric hemodialysis prescription,
Rosenblum ND: Developmental biology of the human
Waters AM, Wu MYJ, Onay T, Scutaru J, Liu J, Lobe CG,
efficacy and outcome. In: Comprehensive Pediatric
Quaggin SE, Piscione TD: Ectopic notch activation in
Nephrology (Geary DF, Schaefer F, eds.). Elsevier Inc.,
kidney. In: Seminars in Fetal and Neonatal Medicine
developing podocytes causes glomerulosclerosis in
Philadelphia, 2008.
(Woolf A, Chitty L, eds.). Elsevier, Philadelphia, 2007.
transgenic mice. Journal of the American Society of
Nephrology 2008: 19(6): pp 1139-1157.
Hothi DK, Harvey EA: Anticoagulation in children
Rosenblum ND, Salomon R: Disorders of kidney
on hemodialysis. In: Handbook of Dialysis Therapy,
formation. In: Comprehensive Pediatric Nephrology
4th Edition (Nissenson A, Fine R N, eds.). Elsevier Inc.,
(Geary DG, Schaefer F, eds.). Elsevier Inc.,
Philadelphia, 2008.
Philadelphia, 2008.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 119
Schroder C, Geary DF: Initiation and choice of dialysis
Canadian Paediatric Clinician Scientist Program.
Control of branching morphogenesis in the normal and
modality. In: Comprehensive Pediatric Nephrology
Rosenblum ND. SickKids Foundation ($300,000 per
dysplastic kidney. Rosenblum ND. Canadian Institutes
(Geary DG, Schaefer F, eds.). Elsevier Inc.,
year 2002-2014)
of Health Research ($147,000 per year 2003-2008)
Philadelphia, 2008.
Canadian Paediatric Clinician Scientist Program.
Control of kidney morphogenesis by sonic hedgehog
Waters AM, Piscione TD: Nephrologic disorders.
Rosenblum ND. B.C. Research Institute for Children’s
and its signalling effectors. Rosenblum ND. Canadian
In: Residents’ Handbook of Neonatology, 3rd Edition,
and Women’s Health ($150,000 per year 2002-2008)
(Kirpalani H, Moore AM, Perlman M, eds.). BC Decker,
Institutes of Health Research ($134,419 per year
2006-2009)
Inc., Hamilton, Ontario, 2007.
Cellular regulation of fractalkine. Lisa Robinson.
FUNDING
($171,944 2005-2007)
Heart and Stroke Foundation of Ontario, Grant-in-Aid
Canadian Child Health Clinician-Scientist Program.
Control of murine kidney development by beta0catenin.
Rosenblum ND. The Kidney Foundation of Canada
($50,000 per year 2006-2008)
Rosenblum ND. Canadian Institutes of Health
Clinical genetic test development for focal segmental
Research ($300,000 per year 2002-2008)
glomerulosclerosis. Piscione TD. National Institutes
Epigenetic changes in urothelium following E. coli
of Health Office of Rare Diseases ($52,000 2007)
infection–new keys to understanding urinary tract
Canada Research Chair in Developmental Nephrology
infection susceptibility. Rosenblum ND. The Hospital
(Tier I). Rosenblum ND. Canada Research Chairs
Clinical practice innovation. Geary DF.
Program ($200,000 per year 2005-2012)
The Hospital for Sick Children Paediatric
Consultants Partnership ($10,000 2007)
120 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
for Sick Children ($50,000 2007-2008)
Evaluation of photograph CQI instrument.
The role of notch signalling in focal segmental
Geary DF. Genzyme Inc. ($11,500 2007)
glomerulosclerosis. Piscione TD. The Hospital for
Sick Children Research Institute ($100,000 2007)
Kids Science. Robinson R. Ministry of Research
and Innovation, Youth Science and Technology
The role of notch signalling in focal segmental
Outreach Program ($150,000 2006-2009)
glomerulosclerosis. Piscione TD. The Hospital for Sick
Children Research Institute ($151,500 2006-2008)
Regulation of the membrane-anchored chemokine,
fractalkine, by Thromboxane A2. Robinson L.
The role of slit/robo signalling in kidney inflammation.
Heart and Stroke Foundation of Ontario
Robinson R. The Kidney Foundation of Canada
($268,452 2007-2010)
($100,000 2007-2009)
The role of notch signalling in focal segmental
The role of slit/robo signalling in renal inflammation.
glomerulosclerosis. Piscione TD. The American
Robinson L. Canada Research Chair, Tier 2
Society of Nephrology ($200,000 2007-2009)
($500,000 2004-2009)
The role of slit/robo signalling pathways in kidney
inflammation. Robinson L. Early Researcher Award,
Government of Ontario ($100,000 2006-2008)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 121
Division of
Dr. Gabrielle deVeber
DIVISION HEAD
Dr. O. Carter Snead III
FULL-TIME
Dr. Rand Askalan
Dr. Brenda Banwell
Dr. Gabrielle deVeber
Dr. Elizabeth Donner
Dr. Cecil Hahn
Dr. Daune MacGregor
Dr. Berge Minassian
Dr. Teesta Soman
Dr. Ingrid Tein
Dr. Jiri Vajsar
Dr. Shelly Weiss
PART-TIME
Dr. Danielle Andrade
Dr. David Berbrayer
Dr. Pamela Cooper
Dr. Jonathan Gladstone
Dr. Jeffrey Kobayashi
Dr. Betty Koo
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Dr.
Dr.
Dr.
Dr.
Dr.
Wayne Langburt
Shanna Lindsay
William Logan
Gilbert Miller
Peter Rumney
HONORARY
Dr. John Lovering
Dr. Douglas McGreal
Dr. E. Gordon Murphy
Dr. Diann Superina-Bell
SCIENTIFIC STAFF
Dr. Miguel Cortez
Dr. Maureen Lovett
Dr. James MacFarlane
Dr. Hiroshi Otsubo
Dr. Elizabeth Pang
Dr. Jose Luis Perez Velazquez
Division of Neurology
OVERVIEW
Chan D: William J. Logan Award for Excellence
Andrade DM, Minassian BA: Genetics of epilepsies.
The major foci of the clinical activities of the Division
in Clinical Teaching, Division of Neurology,
Expert Review of Neurotherapies 2007: 7(6): pp 727-734.
of Neurology are epilepsy, stroke, headache,
The Hospital for Sick Children, 2008.
neurometabolic disease, neuromuscular disease,
Andrade DM, Turnbull J, Minassian BA: Lafora
neurogenetics, sleep disorders, movement disorders,
Elbers J: Prichard Day Prize Winner, Small vessel CNS
disease, seizures and sugars. Acta Myologica
demyelinating diseases, functional neuroimaging
vasculitis: clinical and pathological correlation, 2008.
2007: 26(1): pp 83-86.
Gladstone J: Best Doctors in Canada,
Andrade DM, Carlen PL: Novel anti-seizure drug
Best Doctors, Inc., 2007-2008.
mechanisms. Future Neurology 2007: 2(1): pp 73-86.
as postdoctoral training programs in epilepsy, stroke,
Minassian B: Canadian Paediatric Society
Banwell B: Through the eyes of a child: research
neurometabolic disease and demyelinating diseases.
sanofi pasteur Research Award, 2008.
insights gained through the study of childhood multiple
and neurointensive care.
The Division of Neurology has a Royal College
accredited training program in Child Neurology, as well
sclerosis. Multiple Sclerosis 2008: 14(1): pp 4-5.
In addition, there are a number of graduate students
and postdoctoral fellows in clinical neurophysiology,
Ochi A: William A. Hawke Award for Excellence in
neurogenetics, molecular and cellular neurobiology.
Clinical Teaching, Division of Neurology, The Hospital
Banwell B: Editorial. The long (itudinally extensive)
for Sick Children, 2008.
and the short of it: transverse in children. Neurology
2007: 68(18): pp 1447-1449.
The research foci of the Division of Neurology is
epilepsy (both clinical and basic research),
Taylor M: Annual Josephine Mills Research Award
magnetoencephalography, stroke, dyslexia, burden
for Excellence in MEG Research in Developmental
of disease and quality of life, muscular dystrophy,
Neuroscience, 2008.
Becker DJ, Dosch HM: Abnormal T cell reactivities in
multiple sclerosis, fatty acid oxidation disorders
and molecular and cellular neurobiology.
Banwell B, Bar-Or A, Cheung R, Kennedy J, Krupp LB,
childhood inflammatory demyelinating disease and Type
PUBLICATIONS
1 diabetes. Annals of Neurology 2008: 63(1): pp 98-111.
Amin R, Ford-Jones L, Richardson SE, MacGregor D,
HONOURS AND AWARDS
Tellier R, Heurter H, Fearon M, Bitnun A: Acute
Banwell B, Ghezzi A, Bar-Or A, Mikaeloff AY, Tardieu M:
Akiyama T: Prichard Day Prize Winner, Movie of ictal
childhood encephalitis and encephalopathy
Multiple sclerosis in children: invited review.
high-frequency oscillations combined with intracranial
associated with influenza: a prospective 11-year
Lancet Neurology 2007: 6: pp 887-902.
video EEG in Jacksonian seizures, 2008.
review. Pediatric Infectious Disease Journal 2008:
April 4 [Epub ahead of print].
Dr. Mary Lou Smith
Dr. Margot Taylor
Dr. Robyn Westmacott
SUBSPECIALTY RESIDENTS
Dr. Reem Al-Khater
Dr. Cyrus Boelman
Dr. John Brandsema
Dr. Ryan Hung
Dr. Naila Makhani
Dr. Jorina Elbers
Dr. Emily Tam
DEPARTMENTAL FELLOWS
Dr Juan Pablo Appendino
Dr. Klaus Werner
Dr. Zarazuela Zolkipli
EPILEPSY FELLOWS
Dr. Tomoyuki Akiyama
Dr. Derrick Chan
Dr. Cristina Go
Dr. Zulma Tovar-Spinoza
RESEARCH FELLOWS
Dr. Ayataka Fujimoto
Dr. Ichiro Sugiyama
STROKE FELLOWS
Dr. Lori Billinghurst
Dr. Marilyn Tan
ADMINISTRATIVE STAFF
Cecilia Amorim
Erin Crawford
Maureen Hodge
Fatima Ledo
Michelle Lo
Marilyn McLaughlin
Susy O’Neill
Wendy Ricketts
Barbara Zimnowodzki
The Hospital for Sick Children 2007-08 ANNUAL REPORT 123
Banwell B, Krupp L, Kennedy J, Tellier R, Tenembaum
Barbeau EJ, Taylor MJ, Regis J, Marquis P, Chauvel P,
Bismilla Z, Sell E, Donner EJ: Hashimoto’s
S, Ness J, Belman A, Boiko A, Bykova O, Waubant E,
LiГ©geois-Chauvel C: Spatio-temporal dynamics of face
encephalopathy responding to Risperidone. Journal
Mah J, Stoian C, Kremenchutzky M, Bardini MR,
recognition. Cerebral Cortex 2008: 18(5): pp 997-1009.
of Child Neurology 2007: 22(7): pp 855-857.
Yeh EA, Farrell K, Freedman M, Iivanainen M, Sevon M,
Becker WJ, Gladstone JP, Aube M: Migraine prevalence,
Cheyne D, Bostan AC, Gaetz W, Pang EW:
Bhan V, Dilenge ME, Stephens D, Bar-Or A: Clinical
diagnosis and disability. Canadian Journal of
Event-related beamforming: a robust method for
features and viral serologies in paediatric multiple
Neurological Sciences 2007: 34(4): S3-S9.
presurgical functional mapping using MEG. Clinical
Ruggieri M, Rensel M, Hahn J, Weinstock-Guttman B,
Neurophysiology 2007: 118: pp 1691-1704.
sclerosis: A multinational observational study. Lancet
Neurology 2007: 6: pp 773-781.
Bercovici E, Pang EW, Sharma R, Mohamed IS,
Banwell B, Sled J: Invited editorial. Starting early:
S, Chuang SH, Kemp SM, Rutka JT, Snead OC III,
Holowka S, Rutka J, Weiss S, Chuang S, Snead OC III,
MRI evidence of gray matter atrophy in children with
Otsubo H: Somatosensory evoked fields on
Otsubo H: Extra-operative somatosensory evoked
multiple sclerosis. Neurology 2008: 70: pp 1065-1066.
magnetoencephalography for epilepsy infants younger
potentials confirm the accuracy of MEG SEF
Imai K, Fujimoto A, Ochi A, Viljoen A, Chu B, Holowka
Chu B, Pang EW, Ochi A, Sharma R, Hunjan A,
than four years with total intravenous anaesthesia.
localizations. International Congress Series 2007:
Clinical Neurophysiology 2008: 119: pp: 1328-1334.
1300: pp 637-640.
Pittock SJ: Neuromyelitis optica-IgG in childhood
Bernard T, deVeber G, Benke T: Athletic participation
Clement EM, Godfrey C, Tan J, Brockington M, Torelli S,
inflammatory demyelinating CNS disorders.
after acute ischemic childhood stroke: a survey of
Feng L, Brown SC, Jimenez-Mallebrera C, Sewry CA,
paediatric stroke experts. Journal of Child Neurology
Longman C, Mein R, Abbs S, Vajsar J, Schachter H,
Banwell B, Tenembaum S, Lennon VA, Ursell E,
Kennedy J, Bar-Or A, Weinshenker BG, Lucchinetti CF,
Neurology 2008: 70(5): pp 344-352.
2007: 22(8): pp 1050-1053.
Muntoni F: Mild POMGnT1 mutations underlie a novel
limb-girdle muscular dystrophy variant. Archives of
Neurology 2008: 65(1): pp 137-141.
Datta AN, Hahn CD, Sahin M: Clinical presentation
Dr. Jiri Vajsar and team
and diagnosis of tuberous sclerosis complex in infancy.
Journal of Child Neurology 2008: 23(3): pp 268-273.
124 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Jackson A, Khademian Z, Moon R, Berger E, Kirton A,
Elliott IM, Lach L, Kadis DS, Smith ML: Psychosocial
Hamani C, Hodaie M, Chiang J, del Campo M,
outcomes in children two years after epilepsy surgery:
Andrade DM, Sherman D, Mirski M, Mello L, Lozano A:
deVeber G, Chandran L, During A, Balsam D: Index
has anything changed? Epilepsia 2008: 49(4):
Deep brain stimulation in the anterior nucleus of
of suspicion. Pediatrics in Review 2007: 28(8):
the thalamus: effects of electrical stimulation on
pp 305-311.
pp 634-641.
pilocarpine-induced seizures and status epilepticus.
Epilepsy Research 2008: 78(2-3): pp 117-123.
Katzir T, Kim YS, Wolf M, Morris RD, Lovett MW: The
of epileptiform activity. International Journal of
Herdman AT, Pang EW, Ressel V, Gaetz W, Cheyne D:
subtypes of children with dyslexia at letter, word and
Bifurcation and Chaos 2008: 18(2): pp 429-439.
Task-related modulation of early cortical responses
connected text levels of reading. Journal of Learning
during language production: an event-related synthetic
Disabilities 2008: 41(1): pp 47-66.
Garcia Dominguez L, Wennberg R, Perez Velazquez JL,
aperture magnetometry study. Cerebral Cortex 2007:
Guevara Erra R: Enhanced measured synchronization
17: pp 2536-2543.
GarcГ­a DomГ­nguez L, Guevara Erra R, Wennberg R,
varieties of pathways to dysfluent reading: comparing
Perez Velazquez JL: On the spatial organization
Kirton A, Chen R, Friefeld S, Gunraj C, Pontigon A,
deVeber G: Contralesional repetitive transcranial
of unsynchronized sources: inspecting the physiological
significance of synchronization analysis of whole brain
Imai K, Otsubo H, Sell E, Mohamed I, Ochi A,
magnetic stimulation for chronic hemiparesis in
electrophysiological recordings. International Journal
RamachandranNair R, Snead OC III: MEG source
subcortical paediatric stroke: a randomized trial.
estimation from mesio-basal temporal areas in
Lancet Neurology 2008: 6: pp 507-513.
of Physical Sciences 2007: 2(11): pp 305-317.
a child with a porencephalic cyst. ACTA Neurologica
Scandinavica 2007: 116: pp 263-267.
Kirton A, deVeber G, Pontigon A, MacGregor D, Shroff
isolated syndromes. Annals of Neurology 2008:
Isackson PJ, Bennett MJ, Lichter-Konecki U, Willis M,
classification predicts outcomes. Annals of Neurology
63(3): pp 401-405.
Nyhan WL, Sutton VR, Tein I, Vladutiu GD: CPT2 gene
2008: (63)4: pp 436-443.
Ghassemi R, Antel S, Francis SJ, Banwell B, Arnold
M: Presumed perinatal ischemic stroke: vascular
DL: Lesion distribution in children with clinically
mutations resulting in lethal neonatal or severe
Gladstone JP: Dopamine and migraine:
infantile carnitine palmitoyltransferase II deficiency.
Kirton A, Tan M, Mikulis D, Fisher J, Han J, deVeber G,
trigeminovascular nociception, genetics and
Molecular Genetics and Metabolics 2008: June 10
Rubin B: Recurrent, reversible coma in an adolescent.
therapeutics. Cephalalgia 2007: 27(11): pp 1315–1320.
[Epub ahead of print].
The Lancet Neurology 2008: 7(1): pp 110-112.
Hahn CD: The ARX story: a new twist.
Kirton A, Westmacott R, deVeber G: Pediatric stroke:
Neurology 2007: 69(5): pp 421-422.
rehabilitation of focal injury in the developing brain.
Neurorehabilitation 2007: 22(5): pp 371-382.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 125
Knerr I, Pearl PL, Bottiglieri T, Snead OC III, Jakobs C,
Luca P, Laurin N, Misener VL, Wigg KG, Anderson B,
Mirabella G, Morong S, Buncic JR, Snead OC III,
Gibson KM: Therapeutic concepts in succinate
Cate-Carter T, Tannock R, Humphries T, Lovett MW,
Logan WJ, Weiss SK, Abdolell M, Westall CA: Pediatric
semialdehyde dehydrogenase (SSADH;ALDH5a1)
Barr CL: Association of the dopamine receptor D1
neurology emergencies. Canada International
deficiency (gamma-hydroxybutyric aciduria). Hypotheses
gene, DRD1, with inattention symptoms in families
Scientific Exchange Program, University of Toronto.
evolved from 25 years of patient evaluation, studies
selected for reading problems. Molecular Psychiatry
Contrast sensitivity is reduced in children with
in Ald5a1-/- mice, and characterization of gamma-
2007: 8: pp 776-785.
infantile spasms. Investigative Ophthalmology
and Visual Science 2007: 48(8): pp 3610-3615.
hydroxybutyric acid pharmacology. Journal of Inherited
Metabolic Disease 2007: 30: pp 279-294.
MacGregor DL: Shaken Baby Syndrome: the quest
for evidence. Developmental Medicine and Child
Kolski H, Hawkins C, Zatz M, de Paula F, Biggar D,
Neurology 2008: 50(1): p 8.
Mohamed I, Cheyne D, Gaetz WC, Otsubo H, Logan WJ,
Snead OC III, Pang EW: Spatiotemporal patterns of
oscillatory activity during auditory word recognition in
Alman B, Vajsar J: Diagnosis of limb-girdle muscular
children: a synthesis aperture magnetometry study.
dystrophy 2A by immunohistochemical techniques.
Maguire JL, deVeber G, Parkin P: Association between
Neuropathology 2008: 28(3): pp 264-268.
iron-deficiency anemia and stroke in young children.
International Journal of Psychophysiology 2008: 68:
Pediatrics 2007: 120(5): pp 1053-1057.
pp 141-148.
Lamhonwah AM, Hawkins C, Tam C, Wong J, Mai L,
Tein I: Expression patterns of organic cation/carnitine
Mahant S, Peterson R, Campbell M, MacGregor DL,
Mohamed IS, Otsubo H, Imai K, Shroff M, Sharma R,
transporter family in adult murine brain. Brain and
Friedman JN: Reducing inappropriate hospital use
Chuang SH, Donner EJ, Drake J, Snead OC III: Surgical
Development 2008: 30(1): pp 31-42.
on a general pediatric inpatient unit. Pediatrics 2008:
treatment for acute symptomatic refractory status
121(5): pp e1068-e1073.
Retrospective study of serum protein status in
epilepticus: a case report. Journal of Child Neurology
2007: 22(4): pp 435-439.
Liu YC, Lowe HL, Donner EJ, Kobayashi J:
McLinden A, Baird AD, Westmacott R, Anderson PE,
children fed the ketogenic diet via gastrostomy tube.
deVeber G: Early cognitive outcome after neonatal
Mohamed IS, Otsubo H, Ochi A, Elliott I, Donner EJ,
Journal of American Dietetic Association 2007:
stroke. Journal of Child Neurology 2007: 22(9): pp
Chuang SH, Sharma R, Holowka S, Rutka JT, Snead
107(8): pp 686-695.
1111-1116.
OC III: Utility of magnetoencephalography in the
Lovett MW, Lacerenza L, De Palma M, Steinbach KA,
Menascu S, Donner EJ: Linear Nevus Sebaceous
Frijters JC: Preparing teachers to remediate reading
Syndrome: case reports and review of the literature.
disabilities in high school: what is needed for effective
Pediatric Neurology 2008: 38: pp 207-210.
evaluation of recurrent seizures after epilepsy surgery.
professional development? Teaching and Teacher
Education 2008: 24(4): pp 1083-1097.
126 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Epilepsia 2007: 48: pp 2150-2159.
Nilsson D, Rutka JT, Snead OC III, Raybaud CR,
Otsubo H, Ochi A, Imai K, Fujimoto A, Go C, Dirks P,
Perez Velazquez JL, Garcia Dominguez L, Guevara Erra
Widjaja E: Preserved structural integrity of white
Donner EJ: High-frequency oscillations of ictal muscle
R: Fluctuations in neuronal synchronization in brain
matter adjacent to low-grade tumours. Child’s Nervous
activity and epileptogenic discharges on intracranial
activity correlate with the subjective experience of
System 2008: 24: pp 313-320.
EEG in a temporal lobe epilepsy patient. Clinical
visual recognition. Journal of Biological Physics 2007:
Neurophysiology 2008: 119(4): pp 862-868.
33: pp 49-59.
Nofech-Mozes S, Blaser S, Roifman C, Grunebaum E,
Kobayashi J: Neurological abnormalities in patients
Pang EW, Drake J, Otsubo H, Martineau A, Strantzas
Perez-Velazquez JL, Huo JZ, Dominguez LG, Leschenko Y,
with adenosine deaminase deficiency. Pediatric
S, Cheyne D, Gaetz W: Intraoperative confirmation
Snead OC III: Typical versus atypical absence
Neurology 2007: 37(3): pp 218-221.
of hand motor area identified preoperatively by
seizures: Network mechanisms of the spread of
magnetoencephalography: case report. Pediatric
paroxysms. Epilepsia 2007: 48: pp 1585-1593.
Nylen K, Perez Velazquez JL, Likhodii SS, Cortez MA,
Neurosurgery 2008: 44: pp 313-317.
RamachandranNair R, Ochi A, Benifla M, Rutka JT,
Shen L, Leshchenko V, Adeli K, Gibson KM, Burnham
WM, Snead OC III: A ketogenic diet rescues the
Pedersen CB, KГёlvraa S, KГёlvraa A, Stenbroen V,
Snead OC III, Otsubo H: Benign epileptiform
murine succinic semialdehyde dehydrogenase
Kjeldsen M, Ensenauer R, Tein I, Matern D, Rinaldo P,
discharges in Rolandic region with mesial temporal
deficient phenotype. Experimental Neurology 2008:
Vianey-Saban C, Ribes A, Lehnert W, Christensen E,
lobe epilepsy: MEG, scalp and intracranial EEG
210: pp 449-457.
Corydon TJ, Andresen BS, Vang S, Bolund L, Vockely J,
features. Acta Neurologica Scandinavica 2007:
Bross P, Gregersen N: The ACADS gene variation
13: pp 505-516.
O’Shea AM, Wilson GJ, Ling SC, Minassian BA,
spectrum in 114 patients with short-chain acyl-CoA
Turnbull J, Cutz E: Lafora-like ground-glass inclusions
dehydrogenase (SCAD) deficiency is dominated by
RamachandranNair R, Ochi A, Imai K, Benifla M,
in hepatocytes of pediatric patients: a report of two
missense variations leading to protein misfolding
Akiyama T, Holowka S, Rutka JT, Snead OC III, Otsubo
cases. Pediatric Developmental Pathology 2007:
at the cellular level. Human Genetics 2008: June 4
H: Epileptic spasms in older pediatric patients: MEG
10(5): pp 351-357.
[Epub ahead of print].
and ictal high-frequency oscillations suggest focal-
Ochi A, Otsubo H: Magnetoencephalography-guided
Perez Velazquez JL, GalГЎn, RF, Garcia Dominguez L,
onset seizures in a subset of epileptic spasms.
Epilepsy Research 2008: 78: pp 216-224.
epilepsy surgery for children with intractable focal
Leshchenko Y, Lo S, Belkas J, Erra RG: Phase
epilepsy: SickKids experience. International Journal
response curves in the characterization of epileptiform
Sadeghnia HR, Cortez MA, Liu D, Hosseinzadhe H,
of Psychophysiology 2008: 68: pp 104-110.
activity. Physical Review. E, Statistical, Nonlinear, and
Snead OC III: Anti-absence seizure activity of safranal:
Soft Matter Physics 2007: 76(6 Pt 1): p 061912.
an autoradiographic study. Journal of Pharmacy and
Pharmaceutical Science 2008: 11(3): pp 1-14.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 127
Santoshkumar B, Turnbull J, Minassian BA: Unverricht-
Sugiyama I, Iida K, Akiyama T, Otsubo H: Surgical
Tein I, Elpeleg O, BenZe’ev B, Korman S, Lossos A,
Lundborg progressive myoclonus epilepsy in Oman.
treatment for intractable epilepsies in children.
Lev D, Lerman-Sagie T, Leshinsky-Silver E, Vockley G,
Pediatric Neurology 2008: 38(4): pp 252-255.
Brain Medical 2008: 20: pp 57-65. (Japanese)
Berry G, Lamhonwah AM, Matern D, Roe C, Gregersen
Siintola E, Topcu M, Aula N, Lohi H, Minassian BA,
Sutcliffe TL, Gaetz WC, Logan WJ, Cheyne DO, Fehlings
(319 C>T) presents with clinical heterogeneity and is
Paterson AD, Liu XQ, Wilson C, Lahtinen U, Anttonen
D: Developmental disregard predicts improvement
candidate founder mutation in individuals of Ashkenazi
AK, Lehesjoki AE: The novel neuronal ceroid
after constraint-induced movement therapy in
Jewish origin. Molecular Genetics and Metabolism
lipofuscinosis gene MFSD8 encodes a putative
hemiplegic children. Journal of Developmental and
2008: 93(2): pp 179-189.
lysosomal transporter. American Journal of Human
Behavioural Pediatrics 2007: 28(4): p S3.
N: Short-chain acyl-CoA dehydrogenase gene mutation
Thomas T, Banwell B: Multiple sclerosis in children.
Genetics 2007: 81(1): pp 136-146.
Tagliabracci VS, Turnbull J, Wang W, Girard JM,
Snead OC III, Donner EJ: A new generation of
Seminars in Neurology 2008: 28(1): pp 69-83.
Zhao X, Skurat AV, Delgado-Escueta AV, Minassian BA,
Turnbull J, Kumar S, Ren Z, Shanmugakonar M,
anticonvulsants for the treatment of epilepsy in
DePaoli-Roach AA, Roach PJ: Laforin is a glycogen
children. Paediatrics and Child Health 2007: 12(9):
phosphatase, deficiency of which leads to elevated
Naranian T, Ackerley CA, Minassian BA: Lafora
pp 741-744.
phosphorylation of glycogen in vivo. Proceedings of
progressive myoclonus epilepsy: disease course
the National Academy of Science USA 2007: 104(49):
homogeneity in a genetic isolate. The Journal of
Stewart LS, Nylen KJ, Persinger MA, Cortez MA,
pp 19262-19266.
Child Neurology 2008: 23(2): pp 240-242.
Gibson KM, Snead OC III: Circadian distribution
of generalized tonic-clonic seizures associated
Taylor MJ: MEG in paediatrics: preface to special
Wang CH, Finkel RS, Bertini ES, Schroth M, Simonds
with murine succinic semialdehyde dehydrogenase
issue. International Journal of Psychophysiology
A, Wong B, Aloysius A, Morrison L, Main M, Crawford
deficiency, a disorder of GABA metabolism. Epilepsy
2008: 68(2): pp 83-84.
TO, Trela A, Vajsar J: Consensus statement for standard
of care in spinal muscular atrophy. Journal of Child
and Behaviour 2008: May 29 [Epub ahead of print].
Taylor MJ, Mills T, Smith ML, Pang EW: Face processing
Striano P, Zara F, Turnbull J, Girard JM, Ackerley CA,
in adolescents with and without epilepsy. International
Cervasio M, DeRosa G, Del Basso-De Carro ML, Striano
Journal of Psychophysiology 2008: 68: pp 94-103.
Neurology 2007: 22(8): pp 1027-1049.
Wedderburn L, Varsani H, Li C, Newton K, Amato A,
S, Minassian BA: Typical progression of myoclonic
Banwell B, Bove, Corse A, Emslie-Smith A, Harding P,
epilepsy of the lafora type: a case report. National
Hoogendijk J, Lundberg I, Marie S, Minetti C,
Clinical Practice. Neurology 2007: 4(2): 106-111.
Nennesmo I, Rushing E, Sewry C, Allen E, Charman S,
Pilkington C, Holton J (the International Consensus
Group on JDM Biopsy), and on behalf of the UK
128 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Juvenile Dermatomyositis Research Group:
Wise JC, Sevcik RA, Morris RD, Lovett MW, Wolf M:
International consensus on a proposed score system
The relationship among receptive and expressive
infectious, toxic and metabolic headaches. In: Wolff’s
for muscle biopsy evaluation in patients with JDM,
vocabulary, listening comprehension, pre-reading
Headache and Other Head Pains (Silberstein, Dodick
for potential use in clinical trials. Arthritis Care
skills, word identification skills, and reading
and Lipton, eds.). Oxford University Press, 2007.
and Research 2007: 57(7): pp 1192-1201.
comprehension by children with reading disabilities.
Wells GD, Noseworthy MD, Hamilton J, Tein I:
Bigal ME, Gladstone JP: Headaches attributed to
Journal of Speech, Language, and Hearing Research
Chu B, Pang EW, Ochi A, Sharma R, Hunjan A, Holowka
2007: 50(4): pp 1-17.
S, Rutka J, Weiss S, Chuang S, Snead OC III, Otsubo
Yamazaki M, Ochi A, Akiyama T, Otsubo H: Epileptic
confirm the accuracy of MEG SEF locations. In: New
H: Extra-operative somatosensory evoked potentials
Skeletal muscle metabolic dysfunction in obesity
and metabolic syndrome. Canadian Journal of
Neurological Sciences 2008: 35(1): pp 31-40.
high frequency oscillations. Epilepsy 2008: 2:
Frontiers in Biomagnetism (Cheyne D, Ross B, Stroink
pp 53-60. (Japanese)
G, Weinberg H, eds.). Elsevier, Amsterdam, 2007.
Westmacott R, McAndrews MP, Silver F:
Altered effective connectivity within language
Yoon G, Westmacott R, MacMillan L, Quercia N,
Hahn C, Banwell B: Diseases of the peripheral
networks following left hemisphere stroke.
Koutsou P, Georghiou A, Christodoulou K, Banwell B:
nervous system. In: Pediatric Critical Care Medicine:
Brain and Cognition 2007: 63: p 1999.
Complete deletion of the aprataxin gene: ataxia with
Basic Science and Clinical Evidence (Wheeler DS,
oculomotor apraxia type 1 with severe phenotype and
Wong HR, Stanley TP, eds.). Springer-Verlag,
Westmacott R, McAndrews MP, Silver FL:
cognitive deficit. Journal of Neurology, Neurosurgery,
London, England, 2007.
Understanding medial temporal activation in memory
and Psychiatry 2008: 79: pp 234-236.
Jones-Gotman M, Smith ML, Wieser HG: Intra-arterial
tasks: evidence from fMRI of encoding and recognition
in a case of transient global amnesia. Hippocampus
Zhang Y, Minassian BA: Will my Rett Syndrome patient
amobarbital procedures. In: Epilepsy: A Comprehensive
2008: 18: 317-325.
walk, talk and use her hands? Neurology 2008:
Textbook, 2nd Edition (Engel J, Pedley T, eds.).
70(16): pp 1302-1303.
Lippincott Williams & Wilkins, New York, 2008.
BOOKS AND BOOK CHAPTERS
Kerr M, Smith ML: Learning disorders. In: Epilepsy: A
Widjaja E, Blaser S, Miller E, Kassner A, Shannon P,
Chuang SH, Snead OC III, Raybaud CR: Evaluation of
subcortical white matter and deep white matter tracts
Bayle DJ, Bostan AC, Taylor MJ: Attention to the
Comprehensive Textbook, 2nd Edition (Engel J, Pedley
in malformations of cortical development. Epilepsia
person or the emotion: underlying brain activations in
T, eds.). Lippincott Williams & Wilkins, New York, 2008.
2007: 48: pp 1460-1469.
MEG. In: New Frontiers in Biomagnetism (Cheyne D,
Ross B, Stroink G, Weinberg H, eds.). Elsevier,
Amsterdam, 2007.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 129
MartГ­n del Campo C, PГ©rez VelГЎzquez JL, Cortez MA:
Sharma R, Pang EW, Mohamed I, Chu B, Hunjan A,
FUNDING
EEG recording in rodents. In: Current Protocols in
Ochi A, Holowka S, Gaetz W, Chuang S, Snead OC,
An investigation of the neural mechanisms underlying
Neuroscience (Gerfen C, Rowgawski MA, eds.).
Otsubo H: Magnetoencephalography in children:
amblyopia. Wong A, Taylor MJ, Cheyne DO. Canadian
John Wiley & Sons Inc., New Jersey, 2008.
routine clinical protocol for intractable epilepsy
Foundation for Innovation Leadership Fund
at The Hospital for Sick Children. In: New Frontiers
($1,015,761 2007-2011)
Otsubo H, Imai K: Clinical neurophysiology of cortical
in Biomagnetism (Cheyne D, Ross B, Stroink G,
malformations: magnetoencephalography and
Weinberg H, eds.). Elsevier, Amsterdam, 2007.
electroencephalography. In: Malformations of the
Atypical absence epilepsy: GABA B receptor-mediated
mechanisms. Snead OC III, Francis J, Cortez MA.
Nervous System, Handbook of Clinical Neurology (Sarnet
Stefan H, Olofsson OE, Snead OC III: Typical and
Canadian Institutes of Health Research ($315,376
HB, Curatolo P, eds.). Elsevier Ltd., Edinburgh, 2007.
atypical absence seizures, myoclonic absences, and
2000-2008)
eyelid myoclonias. In: Epilepsy: A Comprehensive
Pang EW, Otsubo H, Sharma R, Hunjan A, Chu B,
Textbook, 2nd Edition (Engel J, Pedley T, eds.).
Autism Treatment Network: Co-operative multicentre
Snead OC III: Unilateral abnormalities on MEG
Lippincott Williams & Wilkins, New York, 2008.
program for research and treatment of autism.
Syndrome. In: New Frontiers in Biomagnetism (Cheyne
Tein I: Primary carnitine transporter defect. In: Neurobase,
Goldfarb C, Berall G, Bradley E, Brian J, Freeman N,
auditory evoked fields in children with Landau-Kleffner
Roberts W, Loh A , Feigenbaum A, Weiss S, Marcon M,
D, Ross B, Stroink G, Weinberg H, eds.). Elsevier,
14th Edition (Gilman N, Goldstein GW, Waxman SG, eds.).
Atkinson A, Taylor MJ, Stinson J, Mitchell S, Green P.
Amsterdam, 2007.
Arbor Publishing Corp., La Jolla, CA, 2008.
Autism Speaks ($1,000,000 2008-2012)
Perez Velazquez JL, Garcia Dominguez L, Wennberg R:
Thomas P, Snead OC III: Absence status epilepticus.
Carnitine-responsive cardiomyopathy and the different-
The fluctuating brain: dynamics of neuronal activity. In:
In: Epilepsy: A Comprehensive Textbook, 2nd Edition
affinity carnitine transporters. Tein I. Heart and Stroke
Nonlinear Phenomena Research Perspectives (Wang
(Engel J, Pedley T, eds.). Lippincott Williams & Wilkins,
Foundation of Ontario ($267,144 2004-2007)
CW, ed.). Nova Science Publishers, Inc.,
New York, 2008.
New York, 2007.
Centre for the Investigation of Neuroplasticity and
Weiss SK: Sleep disorders. In: Adolescent Healthcare:
Developmental Disorders. Snead OC III, Taylor MJ,
RamachandranNair R, Weiss SK, MacGregor D: Sleep
A Practical Guide, 5th Edition (Katzman D, ed.).
Salter M, Josselyn S, Westall C, Dennis M, Tannock R,
and metabolism. In: Head Injury in Children and
Lippincott, Williams & Wilkins, Philadelphia, PA, 2008.
Sled J, Cheyne D, Campbell M. Canadian Foundation
Adolescents (MacGregor D, Kulkarni A, Dirks P,
Rumney P, eds.). MacKeith Press, London, 2007.
130 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
for Innovation ($15,709,086 2006-2011)
Centre for the Study of Complex Childhood Diseases.
Genetics of reading disabilities. Barr CL, Kerr E,
Investigation of an epilepsy epidemic in Cameroon.
Post M (Tein I, CFI Team). Canada Foundation
Lovett MW. Canadian Institutes for Health Research
Snead OC III, Weiss SK, Elliott I, Smith ML,
for Innovation (CFI) ($21,000,000 2007-2012)
($1,125,785 2008-2013)
Stephen D, Keystone J, Cockburn L, Tsang V,
Characterization of factors and mechanisms that
Globus pallidus deep brain stimulation in children with
Children’s Hospital Foundation Chair in
explain the association between physical activity and
dystonia. Soman T, Moro E, Lozano AM, Hodaie M,
Paediatric Neuroscience ($20,000 2007-2008)
lung health in cystic fibrosis: does muscle function
Westmacott R, Gorman D. SickKids Foundation New
play a role? Ratjen F, Coates A, Tein I. Canadian
Investigator’s Grant ($118,617 2008-2010)
Fongwa M, Takougang I, Akeneck J. Bloorview
Krembil Neuroscience Centre Seeding Grant. Andrade
D. Krembil Neuroscience Centre ($39,000 2007-2008)
Cystic Fibrosis Foundation Grant ($158,000
2006-2008)
Health-related quality of life in children with epilepsy:
the first two years after diagnosis through parents’
Making a better brain: an Ontario neuroimaging
CIHR Team in Childhood Obesity Research. McCrindle
eyes. Smith ML, Nixon-Speechley K, Camfield C,
consortium. Menon RS, Bartha R, Chronik BA,
B, Anderson H, Hamilton J, Parkin P, Pencharz P
Wiebe S, Zou G, Levin S. Canadian Institutes of
Henkelman M, Kassner A, Lee TY, Mikulis D, Moller HJ,
(Tein I, co-applicant). Canadian Institutes of Health
Health Research ($393,692 2003-2008)
Rutt BK, Sled JG, Taylor MJ. Ontario Research
Foundation ($4,161,595 2008-2011)
Research ($2,452,522 2008-2013)
Identification of genetic causes of paediatric
Cognitive behavioural therapy as a novel approach to
neurological conditions and using these to uncover the
MEB diseases. Vajsar J. SickKids Foundation
the management of dystonia in children: a pilot study.
cellular pathways involved and to determine the ways
($37,000 2006-2007)
Soman T, Logan W, Chen R, O’Driscoll H. SickKids
in which they are disturbed. Minassian BA. Canada
Foundation ($4,500 2007-2008)
Research Chairs Program ($478,585 2006-2011)
Molecular basis of Lafora bodies (starch formation
in the brain) and Lofora’s progressive myoclonus
epilepsy. Minassian BA, Ackerley CA, Scherer SW,
CREMS – Comprehensive Research Experience for
Immune regulation and biomarker development for
Medical Students. Weiss SK, Zak M, Mulligan J. The
paediatric and adult autoimmune diseases. Bar-Or A,
Lohi H. Canadian Institutes of Health Research
Hospital for Sick Children, Division of Neurology;
Banwell B, Piccirillo P, Sherman P, Polychronakos C.
($1,146,830 2006-2011)
CREMS-University of Toronto ($5,000 2008)
Canadian Institutes of Health Research New
Emerging Team Grants ($2,018,445 2007-2012)
Curing adult polyglucosan body disease by eliminating
Multimodal neuroimaging of frontal lobe cognitive
function in children. Taylor MJ, Donner, EJ, Pang EW.
the polyglucosan bodies. Minassian BA. Adult
Canadian Institutes of Health Research ($466,335
Polyglucosan Body Disease Research Foundation
2006-2011)
($59,000 2007-2008)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 131
Multimodal neuroimaging and neurobehavioural
Neuroimaging measures of brain function in preterm
Prospective study of the clinical epidemiology,
outcomes in preterm neonates. Taylor MK, Whyte H,
neonates. Taylor MJ, Sled JG, McNamara P, Whyte
pathology, and neuroimaging features of Canadian
Shroff M, Donner E, Moore A, Soman T. Canadian
HEA, Moore AM, Donner EJ, Shroff MM. Collaborative
children with clinically isolated demyelinating
Institutes of Health Research ($925,000 2007-2012)
Health Research Program ($361,860 2008-2011)
syndromes. Banwell B, Bar-Or A, Sadovnick D, Arnold
Multiple-component remediation for struggling
Neuroimaging measures of brain function in preterm
($4,300,000 2004-2009)
D. Multiple Sclerosis Scientific Research Foundation
middle school readers. Morris R, Lovett MW,
neonates. Taylor M, Donner EJ, McNamara PJ,
Sevcik R, Frijters JC. Institute of Education Sciences
Moore AM, Shroff MM, Sled JG, Whyte HEA: Natural
Randomized controlled trial to improve sleep in children
($2,882,630 US 2006-2010)
Sciences and Engineering Research Council
who have both epilepsy and neurodevelopmental
of Canada ($361,860 2008-2011)
disabilities. Weiss SK. The Hospital for Sick Children
National Grants Program ($121,328 2007-2009)
Multi-site paediatric network for fMRI mapping in
childhood epilepsy. Smith ML, Gaillard WD.
Neuroprotection by inhibitors of apoptosis proteins
American Epilepsy Society ($60,000 2005-2007)
following neonatal stroke. Askalan R. Clinician-
Role of the carnitine/organic cation transporters in
Scientist Award (Phase I), Heart and Stroke
the mammary gland and implications for the suckling
Foundation of Ontario ($50,000 2007-2010)
infant. Tein I. Mead-Johnson Grant ($28,500 2007-2008)
Murine knockout model of 4-hydroxybutyric aciduria.
Snead OC III, Gibson KM. National Institute of
Non-invasive decompression of the superior sagittal
Shared epitopes of functional variants of the organic
sinus to prevent perinatal brain injury in neonatal
cation/carnitine transporter family (OCTN1 and OCTN2)
Murine treadmill (6-lane) with electric shocker. Tein I.
cerebral sinovenous thrombosis. deVeber G, Kirton A,
and campylobacter jejuni may underlie susceptibility to
SickKids Foundation Equipment Grant ($6,500 2008)
Tan M, Shroff M, Moore A. Ontario Federation for
Crohn’s disease and Guillain-Barre syndrome. Tein I.
Cerebral Palsy ($12,875 2007-2008)
SickKids Foundation ($5,000 2007-2008)
with autism. Taylor M, Donner EJ, Roberts SW,
Predicting neurobehavioural outcome in preterm
Spatio-temporal patterns of synchronized brain activity
Bayless S, Shroff M. National Alliance for Autism
neonates. Taylor M.J, Whyte HE, Raybaud C, Moore
Perez Velazquez JL. National Science and Engineering
Research ($155,907 2006-2008)
AM, Donner EJ, Shroff MM, Frisk VA. Canadian
Research Council of Canada Discovery Grant
Institutes of Health Research ($929,129 2007-2012)
($172,165 2007-2011)
Health ($587,500 USD 2006-2011)
Neuroimaging and frontal lobe function in children
132 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
The Children’s Stroke Project. deVeber G. Anonymous
TIPS (Tips for Infant and Parent Sleep). Stremler R,
Validation of accelerometry as a measure of physical
Children’s Foundation ($2,070,000 2001-2009)
Weiss SK, Hodnett E, Lee K, MacFarlane J, Willan A.
activity and inactivity in children with chronic disease.
Canadian Institutes of Health Research ($274,846
Feldman B, Stephens S, Takken T, Van der Net J,
2007-2009)
Tremblay M, Eslinger D, Bigger W, Wright V,
The practice of paediatric movement disorders amongst
Schneiderman-Walker J, Longmuir P, Banwell B,
paediatricians. Soman TB, Lamba D, Logan WJ,
Beyenne J. Canadian Institutes of Health Research,
Lang AE. SickKids Foundation ($500 2006-2008)
Towards the correction of Rett-like behaviour in
MeCP2-deficient mice by exogenous gene delivery.
Institute of Musculoskeletal Health and Arthritis -
The role of muscle carnitine deficiency and the
Snead OC III. Canadian Institutes of Health Research
Seed Grant: Physical Activity, Sport and Health
carnitine/organic cation transporter family in
($117,137 2004-2009)
Competition ($64,985 2007-2008)
Duchenne muscular dystrophy. Tein I. SickKids
Traumatic brain injury in children and youth: the
Validation of the NIH stroke scale in children. deVeber
complexities of co-morbidities. Perez Velazquez JL,
G, Ichord R. National Institute of Neurological
The role of vigabatrin in the treatment of infantile
Hutchison J, Schachar R. Ontario Neurotrauma
Disorders and Stroke ($45,000 2006-2009)
spasms. Carmant L, Weiss, SK. Canadian Institutes
Foundation ($250,000 2007-2010)
Foundation ($7,650 2007-2008)
Variability of brain coordination dynamics as a
of Health Research ($860,000 2003-2009)
Unravelling the pathogenesis of the autophagic
prognostic tool in traumatic brain injury. Perez
The Ts65Dn mice model. Cortez MA. SickKids
vacuolar myopathies. Minassian BA, Ackerley C,
Velazquez JL. SickKids Foundation ($48,500
Foundation ($10,000 2005-2008)
Manolson MF. Canadian Institutes of Health
2007-2008)
Research ($779,395 2007-2012)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 133
Division of
Dr. Angelo Mikrogianakis
DIVISION HEAD
Dr. William Mounstephen
FULL-TIME
Dr. Kathy Boutis
Dr. Kevin Chan
Dr. Seen Chung
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Yaron Finkelstein
Stephen Freedman
Shauna Jain
Anna Jarvis
Kelly Keogh
Luba Komar
Amina Lalani
Dr. Sanjay Mehta
Dr. Angelo Mikrogianakis
Dr. Bruce Minnes
Dr. Trent Mizzi
Dr. Jonathan Pirie
Dr. Savithiri Ratnapalan
Dr. Susan Schneeweiss
Dr. Suzanne Schuh
Dr. Dennis Scolnik
Dr. Jennifer Thull-Freedman
PART-TIME
Dr. Sherry Baine
Dr. Susanna Benseler
Dr. Carolyn Calpin
Dr. Joseph Copeland
Dr. Anh Do
Dr. Janine Flanagan
Dr. John Freedman
Dr. Claudio Fregonas
Dr. Sabine George
Dr. Cara Gilman
Dr. Peter Glazer
Dr. Donna Goldenberg
Dr. Massoud Grouhi
Dr. Shuja Hafiz
Dr. Mark Handley-Derry
Dr. Leah Harrington
Division of Paediatric Emergency Medicine
OVERVIEW
paediatric emergency medicine knowledge and skills.
HONOURS AND AWARDS
The Emergency Department (ED) at The Hospital for
We have also worked with the Canadian Armed Forces
Chan K: Division of Paediatric Emergency Medicine,
Sick Children provides acute care to children who are ill
to provide paediatric training to their physician
The Hospital for Sick Children Research Recognition
or who have been injured. We are both the primary care
assistants. We provide telephone consultative support
Award in recognition of excellence in outstanding
centre for children in Toronto, plus the tertiary referral
to the Canadian Armed Forces in Afghanistan for any
effort and contribution to research, 2007-2008.
centre for the Greater Toronto Area (GTA), in addition to
paediatric concerns they may encounter. The division
being the designated Paediatric Trauma Centre for the
continues to run Paediatric Life Support Courses (PALS
Chan K: Fellow, Munk Centre for International Studies,
GTA. The division has 21 full-time staff, the majority of
and APLS). We also have a well-developed weekly
University of Toronto, 2007.
whom are recertified in both paediatrics and paediatric
half-day of educational activities for trainees and all
emergency medicine, plus a cadre of part-time
health care providers in the Emergency Department.
Dr. Leah Harrington: RHA Haslam, Pre-clerkship
paediatricians. Over the next two to three years we will
In the fall, the division will present the fifth annual
Teaching Award, Department of Paediatrics, The
be redeveloping the Emergency Department’s physical
Paediatric Emergency Medicine Update which in the
Hospital for Sick Children, University of Toronto, 2008
plant. This redevelopment will ensure that the ED at
past four years has been an overwhelming success.
SickKids remains a leader in paediatric emergency care.
In addition, we have recently introduced an electronic
Mehta S: RHA Haslam Pre-clerkship Teaching Award for
Research in the division remains clinically focused,
Excellence in Pre-clerkship Teaching (Runner-up), 2008.
tracking system that replaces the old white board.
covering a wide range of topics from respiratory
These changes will allow us to provide more efficient
disease acute care management, orthopaedic injuries,
Mikrogianakis A: The Hospital for Sick Children,
and effective care to our patients.
pain and sedation, to drug errors. Research done
Department of Paediatrics, the Richard Rowe Award
within the division continues to be presented
for Clinical Excellence in Paediatric Medical Care
The division has an active three-year academic
nationally and internationally with publications in
(Junior Award), 2008.
fellowship program. The Royal College of Physicians
peer-reviewed journals. Overall, a substantial increase
and Surgeons has fully accredited our fellowship
in clinical research activities has resulted, putting
Mikrogianakis A: Clinical Recognition Award. In
program. In addition, we have a number of clinical
us on par with the other North American leaders in
recognition of outstanding effort and contribution
departmental fellows from around the world spending
paediatric emergency medicine.
to the Emergency Department, Division of Paediatric
a year or more with us further developing their
Emergency Medicine Awards Day, 2008.
Mikrogianakis A: Postgraduate PERLS Teaching Award
(Runner-up), 2008.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Nicole Inch
Edward Jin
Eddy Lau
Yen Le
Patricia Linders
Steven Moss
Patricia Neelands
Dr. Carole O’Beirne
Dr. Linda Pedder
Dr. Christina Ricks
Dr. Jennifer Riley
Dr. Lillian Rojnica
Dr. Domenick Shelton
Dr. Heshy Sturm
Dr.
Dr.
Dr.
Dr.
Dr.
Rahim Valani
Charmaine Van Schaik
Jeff Weisbrot
Sheldon Wise
Hirotaka Yamashiro
CROSS-APPOINTEES
Dr. Eyal Cohen
Dr. Astrid Guttmann
Dr. Ronik Kanani
Dr. Christoph Licht
Dr. Jonathan Tolkin
Dr. Hilary Whyte
Dr. Jamie Hutchison
CLINICAL FELLOWS
Dr. Amir Ahmad
Dr. Samim Al-Qadhi
Dr. Miguel Glatstein
Dr. Alexandra Hernandez
Dr. Maria Oliva
Dr. Charles Stewart
Dr. Klaus Werner
ACADEMIC FELLOWS
Dr. Abdullah Al-Dhafian
Dr. Nesrin Alharthy
Dr. Ahmed Al-Saleh
Dr. Alawi Baaboud
Dr. Vered Gazit
Dr. April Kam
The Hospital for Sick Children 2007-08 ANNUAL REPORT 135
Mikrogianakis A: Lionel Weinstein Clerkship Teaching
PUBLICATIONS
Dubnov-Raz G, Fogelman R, Juurlink D. N, Merlob P,
Award for Excellence in Teaching, Department of
Al-Ansari K, Sulowski C, Ratnapalan S: Analgesia and
Ito S, Koren G, Finkelstein Y: Prolonged QT interval in
Paediatrics, The Hospital for Sick Children, University
sedation practices for incarcerated inguinal hernias
neonates exposed to selective serotonin reuptake
of Toronto (Runner-up), 2008.
in children. Clinical Pediatrics (Philadelphia) 2008:
inhibitors in late pregnancy. Clinical Pharmacology
May 19 [Epub ahead of print].
and Therapeutics 2008: 83: p S42.
Pirie J: Award for Excellence in Postgraduate Medical
Education in Teaching Performance/Mentorship/
Avner M, Finkelstein Y, Hackam D, Koren G:
Finkelstein Y, Schechter T, Garcia F, Nurmohamed L,
Advocacy, University of Toronto, 2008.
Establishing causality in pediatric adverse drug
Juurlink D, Blanchette V, Koren G: Is morphine
reactions: use of the Naranjo Probability Scale.
exposure associated with acute chest syndrome in
Pirie J: Continuing Education Award. For excellence
Pediatric Drugs 2007: 9: pp 267-270.
Paediatrics, The Hospital for Sick Children, 2008.
children with vaso-occlusive crisis of sickle cell
disease? A 6-year case-crossover study. Clinical
in long-term contribution to CE in the Department of
Boutis K, Willison D: To pay or not to pay: is that the
Therapeutics 2007: 29: pp 2738-2743.
right question? Student BMJ 2008: 16: pp 118-119.
Finkelstein Y, Garcia-Bournissen F, Schechter T,
Pirie J: Clinical Teaching Award, Division of Paediatric
Nurmohamed L, Koren G: Is morphine administration
Emergency Medicine, The Hospital for Sick Children
Brandao L, Harrington D. J, Finkelstein Y, Cohen E,
(Runner-up), 2008.
Thompson M, Verjee Z: Superwarfarin exposure and
to children with sickle cell disease: and vaso-occlusive
severe coagulopathy in two infants: novel biomarkers
crisis associated with an increased risk for the
Schuh S: Article selected as one of the Best Articles
for diagnosis and prolonged therapy. Clinical
development of acute chest syndrome: a case-
Relevant to Pediatric Immunology by the American
Toxicology 2007: 45: pp 637.
fluticasone does not replace oral prednisolone in
children with mild to moderate acute asthma.
Scolnik D: Global Health Scholar, Peter A. Silverman
Chan KJ: A clinical trial gone awry: the Chocolate
Happiness Undergoing More Pleasantness (CHUMP)
Finkelstein Y, Nava-Ocampo AA, St. Pierre E,
study. Canadian Medical Association Journal 2007:
Schechter T, Walker S, Koren G: Population
177: pp 4-5.
pharmacokinetics of doxorubicin in infants and
children with malignant diseases. Clinical
Centre for International Health, Mount Sinai Hospital,
University of Toronto, 2007.
Dubnov G, Finkelstein Y, Koren G: Recommend n-3
fatty acids in pregnancy? Canadian Family Physician
2007: 53: pp 1299-1300.
Dr.
Dr.
Dr.
Dr.
Melissa Parker
Tania Principi
Ayelet Rimon-Babad
Hayat Saddeq
ADMINISTRATIVE STAFF
Majda Savaglio
Andrew Serrano
Sabrina Dubeau
Nicole Winters
Maggie Stevanovic
cross-over study. Clinical Pharmacology and
Therapeutics 2007: 81: pp S78-S79.
Academy of Pediatrics. Title: High-dose inhaled
Deborah Atchison
Joanna Barnes
Dana Doll
Ritsa Iriotakis
Patricia Nedanovski
Pauline Smith
Viki Dukic
Traci Peggie
Sandra Miller
Pharmacology and Therapeutics 2007: 81: p S78.
Finkelstein Y, Fogelman R, Juurlink D. N, Merlob P, Ito S,
Goldman RD, Mounstephen W, Langer J: Prospective
Mikrogianakis A, Osmond MH, Nuth JE, Shephard A,
Koren G, Dubnov-Raz G: Antenatal exposure to selective
validation of pediatric appendicitis score. Journal of
Gaboury I, Jabbour M: Evaluation of a multidisciplinary
serotonin reuptake inhibitors prolongs the QT Interval in
Pediatrics 2008: March 19 [Epub ahead of print].
pediatric mock trauma code educational initiative: a
pilot study. Journal of Trauma 2008: 64(3): 761-767.
Neonates. Clinical Toxicology 2007: 45: p 624.
Goldman RD, Narula N, Klein-Kremer A, Finkelstein Y,
Freedman SB, Adler M, Seshadri R, Powell EC:
Rogovik AL: Predictors for opioid analgesia
Osmond MH, Gazarian M, Henry RL, Clifford T, Tetzlaff
Antiemetics for acute gastroenteritis: a never ending
administration in children with abdominal pain
J, Mikrogianakis A, and the PERC Spacer Study Group:
story. Journal of Pediatric Gastroenterology and
presenting to the emergency department. Clinical
Barriers to metered-dose inhaler/spacer use in
Nutrition 2007: 45: pp 132-133.
Journal of Pain 2008: 24(1): pp 11-15.
Canadian pediatric emergency departments. Academic
Freedman SB: Acute infectious pediatric gastroenteritis:
Goldman RD, Scolnik D, Chauvin-Kimoff L, Farion KJ, Ali
beyond oral rehydration therapy. Expert Opinion on
S, Lynch T, Gouin SM, Osmond M, Johnson DW, Klassen
Pirie J: Pre- and post-paediatric emergency care:
Pharmacotherapy 2007: 8: pp 1651-1665.
TP: Practice variation among paediatric emergency
where do we go from here? Paediatrics and Child
physicians in the management of febrile neonates.
Health 2007: 12: p 451.
Emergency Medicine 2007: 14(11): pp1106-1113.
Freedman SB, Thakkar VA: Easing the strain on a
Paediatric Child Health 2007: 12 Suppl: p 61A.
Ratnapalan S: Cutting the vagus nerve: clinical
pediatric tertiary care center: the use of a
redistribution system. Archives of Pediatrics and
Harrington DJ, Dominic J, Brandao LR, Leonardo R,
practice and research in medicine. Canadian Family
Adolescent Medicine 2007: 161(9): pp 870-876.
Cohen E, Finkelstein Y, Thompson M, Verjee Z:
Physician. 2008: 54(5): p 748.
Superwarfarin exposure and severe coagulopathy in
Freedman SB, Haladyn JK, Floh A, Kirsh J, Taylor G,
two infant immigrants: unequivocal diagnosis using
Ricks C, Ratnapalan S, Jain S, Tait G: Evaluating
Thull-Freedman J: Pediatric myocarditis: emergency
novel biomarkers. Therapeutic Drug Monitoring 2007:
computer-assisted learning for common pediatric
department clinical findings and diagnostic evaluation.
29: p 466.
emergency procedures. Pediatric Emergency Care
2008: 24(5): pp 284-286.
Pediatrics 2007: 120(6): pp 1278-1285.
Mehta SV: Neuroimaging for pediatric minor closed
Freedman SB, Thull-Freedman J: Pediatric dehydration
head injuries. Paediatrics and Child Health 2007:
assessment and oral rehydration therapy. Pediatric
12(6): pp 482-484.
Emergency Medicine Reports 2008: 13(2): pp13-28.
Schechter T, Finkelstein Y, Williams S, Chan A K, Ali M,
Brandao LR, Leonardo R: Dosing and safety of
unfractionated heparin in infants with thrombotic
complications. Pediatric Blood and Cancer 2007:
48: pp 642-643.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 137
Schecheter T, Afzal S, Finkelstein Y, Doyle J, Dupuis L:
BOOKS AND BOOK CHAPTERS
Finkelstein Y: Poisoning in pregnancy. In: Medication
Daclizumab therapy for pediatric steroid-resistant
Chan K: Economics and global health. In: Understanding
Safety in Pregnancy and Breastfeeding (Koren G, ed.).
graft-versus-host disease. Paediatric Transplantation
Global Health (William Markle, Melanie Fisher, Ray
McGraw Hill Publication, New York, 2007.
2008: May 11 [Epub ahead of print].
Smego, eds.). McGraw Hill Press, New York, 2007.
Scolnik D, Lovinsky R, Aronson L, Toledano K, Glazier
Chan K, Rosenberg M, Stewart CC, Hall T: Hurdles and
Mehta SV: Smoke inhalation. In: The Hospital for
Sick Children Manual of Pediatric Trauma (Cheng A,
R, Eisenstadt J, Eisenberg P, Wilcox L, Rowsell R,
opportunities in global health program. In: Developing
Mikrogianakis A, Valani R, eds.). Lippincott, Williams
Silverman M: Efficacy of a targeted, oral penicillin-
Residency Training in Global Health: A Guidebook
& Williams, Toronto, 2007.
based yaws control program among children living in
(Evert J, Stewart C, Chan K, Rosenberg M, Hall T,
rural South America. Clinical Infectious Disease 2003:
eds.). Global Health Education Consortium, San
Pirie J, Hutchison C: Pediatric procedures. In: The
36(10): pp 1232-1238.
Francisco, 2008.
Hospital for Sick Children Handbook of Pediatrics,
11th Edition (Dipchand A, Friedman J, eds.). Elsevier
Canada, Toronto, 2008.
Tallett S, Lingard L, Hellmann J, Hilliard R, Hurley J,
Chan K, Stewart CC, Hall T: Resources for teaching in
Leslie K, Jefferies A, Mian M, Pirie J, Rosenfield J,
global health. In: Developing Residency Training in
Schneider R, Spero L: Measuring educational
Global Health: A Guidebook (Evert J, Stewart C, Chan
Scolnik D: Health as a bridge to peace: CISEPO
workload: a pilot study of paper-based and PDA tools.
K, Rosenberg M, Hall T, eds.). Global Health
as a case study. VDM Verlag Dr. Muller, Saarbrucken,
Medical Teacher 2008: 30: pp 296-301.
Education Consortium, San Francisco, 2008.
Germany, 2007.
Stewart CC, Dillibaugh L, Chan K: Examples of global
Warren DW, Jarvis DA, LeBlanc L, Gravel J, and
Creery D, Mikrogianakis A: Sudden infant death
the CTAS National Working Group (NWG): Revisions
syndrome, BMJ Clinical Evidence Handbook, BMJ
health curricular components. In: Developing
to the Canadian Triage and Acuity Scale Paediatric
Publishing Group Ltd., London, UK, 2007.
Residency Training in Global Health: A Guidebook
Evert J, Stewart C, Chan K, Rosenberg M, Hall T:
eds.). Global Health Education Consortium, San
Developing Residency Training in Global Health:
Francisco, 2008.
(Evert J, Stewart C, Chan K, Rosenberg M, Hall T,
Guidelines (PaedCTAS) ED administration. Canadian
Journal of Emergency Medicine 2008: 10(3): p 224.
A Guidebook. Global Health Education Consortium,
San Francisco, 2008.
138 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
FUNDING
Children with fractures suspicious for abuse. Why are
Predictors for diagnostically accurate ultrasound
A randomized controlled trial of casting versus wrist
they missed in the emergency department? Boutis K,
in children with suspected appendicitis. Doria A,
splint in children with minimally angulated distal radius
Alharty N, Cory E, Au H, Ravichandiran N. Canadian
Schuh S, Cheng A, Langer J, Tomlinson G.
fractures in children. Boutis K, Howard A, Babyn P,
Hospitals Injury Reporting and Prevention Program
SickKids Foundation ($128,000 2007-2009)
Willan A. SickKids Foundation ($129,775 2006-2008)
($4,000 2006-2007)
Palatability of oral rehydration solutions (PORS).
Barriers on the use of paediatric ankle X-ray decision
Global health education consortium global health
Freedman SB, Boutis K, Schuh S. Paediatric
rules. Boutis K, Constantine E, Narayanan U. The
modules. Hall H, Chan K, Neusy A-J, Jones E.
Consultants Partnership’s Grant ($8,210 2007-2009)
Hospital for Sick Children Paediatric Consultants
Margaret Kendrick Blodgett Foundation
Partnership’s Grant ($6,650 2007-2008)
($275,000 2006-2008)
Emergency department rapid intravenous rehydration
Funding for the position of a research co-ordinator
Roifman C, Richardson S, Schuh S. The Hospital for
(RIVR) for paediatric gastroenteritis: a randomized
in the emergency department. Schuh S. Trudell
Sick Children Research Institute ($33,800 2007-2008)
controlled trial. Freedman S, Parkin P, Willan A,
Medical ($50,000 2006-2008)
Severe influenza in children: genetic determinants and
related epidemiology. Tran D, Paterson A, Beyene J,
Severe influenza in children: genetic determinants and
Schuh S. Physicians’ Services Incorporated
Foundation ($165,000 2006-2008)
Evaluate run exercises trained versus non-trained to
related epidemiology. Tran, D, Paterson A, Beyene J,
Impact of oximetry on hospitalization in acute
bronchiolitis. Schuh S, Freedman SB, Coates A,
Roifman C, Richardson S, Schuh S. University
Parkin P, Allen U, Willan A, Ungar W, Da Silva Z.
of Toronto Dean’s Fund ($10,000 2007-2008)
evaluate the impact of the curriculum on performance.
Physicians’ Services Incorporated Foundation
Komar L. National CBRNE ($2.8 million 2008-2010)
($163,000 2007-2009)
The MAST project: magnesium for sickle cell trial.
Goldman RD, Kirby-Allen M, Mounstephen W,
Exploring novel methods to improve our diagnostic
Impact of oximetry on hospitalization in acute
Friedman J. Physician’s Services Incorporated
accuracy of childhood bacterial pneumonia. Lynch T,
bronchiolitis. Schuh S, Freedman SB, Coates A,
Foundation ($157,000 2006-2008)
Klassen T, Boutis K, Johnson. Canadian Institutes
Parkin P, Allen U, Willan A, Ungar W, Da Silva Z.
of Health Research ($75,000 2006-2009)
Thrasher Research Fund ($125,000 2007-2010)
Young infants with acute recurrent wheezing: to puff or
not to puff? A randomized controlled trial. Grassemann
Isotonic versus hypotonic IV maintenance fluids
H, Schuh S, Willan A, Dick P, Coates A, Ungar W.
in children: a randomized controlled trial. Geary D,
SickKids Foundation ($169,500 2008-2010)
Freedman SB, Beck C, Freidman JN. Paediatric
Consultants Partnership’s Grant ($9,956 2007-2008)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 139
Division of
Dr. Zia Bismilla
DIVISION HEAD
Dr. Jeremy Friedman
FULL-TIME
Dr. Hosanna Au
Dr. Carolyn Beck
Dr. Stacey Bernstein
Dr. Catherine Birken
Dr. Zia Bismilla
Dr. Trey Coffey
Dr. Eyal Cohen
Dr. Emma Cory
Dr. Astrid Guttmann
Dr. Robert Hilliard
Dr. Sanjay Mahant
Dr. Charlotte Moore
Dr. Patricia Parkin
Dr. Elena Pope
Dr. Adam Rapoport
Dr. Michelle Shouldice
Dr. Susan Tallett
Dr. Michael Weinstein
MAJOR PART-TIME
Dr. Mark Feldman
Dr. Saul Greenberg
Dr. Moshe Ipp
Dr. Sheila Jacobson
Dr. Michael Peer
Dr. Miriam Weinstein
PART-TIME
Dr. Tony Barozzino
Dr. Salvatore Cammisuli
Dr. Nhung Ho
Dr. Alex Levin
Dr. Michael Sgro
Dr. Christine Webster
ASSOCIATE
Dr. Nirit Bernhard
Dr. Mariana Boragina
Dr. Ronik Kanani
Dr. Sanjeev Luthra
Dr. Ivor Margolis
Dr. Sharon Naymark
Division of Paediatric Medicine
OVERVIEW
The divisional complex care program continues to
section. Dr. Jeremy Friedman is an associate editor
Faculty in the the Division of Paediatric Medicine had a
develop under the leadership of Dr. Eyal Cohen, whose
of the Paediatrics and Child Health Journal. The two
successful and productive year in 2007-08. In 2008,
efforts were recognized by his selection to join the
books for parents written by divisional members
we welcomed one new full-time faculty, Dr. Zia Bismilla.
Ontario MOH expert panel on complex care in children.
(Caring for Kids, 2006 and Canada’s Baby Care, 2007)
After completing her residency with her final year as
On the clinical side, a dedicated inpatient complex
and edited by Drs. Friedman and Saunders, are both
associate chief resident, Zia was accepted into the
care team now operates four to six beds and is staffed
Canadian bestsellers and on sale internationally as well.
Paediatric Medicine fellowship. During her two-year
by a hospitalist with complex care expertise and a
fellowship, she successfully completed her Masters of
nurse practitioner. The ambulatory arm of the complex
This has been a successful year with regards to
Education at OISE and was also resident editor of the
care team has just begun taking referrals through
research productivity. There were over 20 abstracts
11th Edition of the SickKids Handbook. Her major
ARMs, although capacity remains limited at this time.
from the division at the annual PAS and CPS meetings,
academic interest is in the area of simulation, and she
The hospital has helped fund a proposed pilot project
including many platform presentations. Funding from
presented her research at the CPS and PAS meetings.
to study a new model of care, whereby a medical home
both internal and external agencies was secured,
for the most complex multi-system patients with high
including a number of CIHR grants. PORT, under the
Our part-time inpatient hospitalist group has grown
resource requirements would be developed in their
leadership of Dr. Patricia Parkin, was funded by the
and now includes Drs. Ronik Kanani (NYGH), Yehuda
community hospitals in collaboration with the SickKids
SickKids Foundation for a further five-year term. Many
Mozes (SCH), Ivor Margolis and Sanjeev Luthra
program. The Norman Saunders Complex Care
manuscripts were published in top general paediatric
(WOMC), Tony Barozzino, Mike Sgro and Ethel Ying
Initiative will award its first research grants after
journals (see below).
(St. Mike’s). These individuals, who function as
the inaugural annual competition this summer.
Once again, the residents identified their general
hospitalists/consultants at their �home’ hospitals,
each provide us with two to four weeks of inpatient
Faculty members continued to excel and gain
paediatric ward rotation as their best experience of
attending every six months, connecting our tertiary
recognition as leaders in the field of paediatric medicine.
the year, and many faculty members were recognized
care group more closely to the community and the
Dr. Robert Hilliard was elected to the position of VP
with teaching awards (see below). Special mention
care provided outside of SickKids. Their contribution
of the Canadian Paediatric Society, and will serve as
to Dr. Stacey Bernstein, who won the prestigious
is much appreciated. A formal fellowship in
president in two years time. Dr. Sanjay Mahant was
University of Toronto WT Aikins Award, and Dr. Eyal
Community Paediatrics has been developed under
elected president of the Hospital Medicine section
Cohen for winning the Department of Paediatrics
the leadership of Dr. Mark Feldman, with the support
at the CPS, while Dr. Mark Feldman is the current
Harry Bain Award.
of the Department of Paediatrics at SickKids, and
president of the Community Paediatrics
the first fellow will start her training in 2009.
Dr. Yehuda Nofech-Mozes
Dr. Gary Sibbald
Dr. Ethel Ying
ADJUNCT
Dr. Peter Azzopardi
Dr. Ranjit Baboolal
Dr. Anna Banerji
Dr. Bert Cellupica
Dr. Patricia Colangelo
Dr. Hilary de Veber
Dr. Paul Dick
Dr. Suhid (Tony) D’Souza
Dr. Michelle Farine
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Claudio Fregonas
Gerald Friedman
Marvin H. Gans
Hartley A. Garfield
Morton Goldbach
Leslie Goodis
Stuart Gordner
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Michelle Gordon
Masoud Grouhi
James D. Hilton
Tommy Ho
Alan P. Hudak
Anthony Y.T. Hui
Edward G. Jin
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Beverley Kupfert
Eddy Lau
Cinda B.S. Lee
Maurice Levy
Aubrey Maze
Anilkumar Menon
Saba Merchant
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Steven Moss
Larry B. Pancer
John Philpott
S. Joseph Porepa
Vladimir Pucholt
Percy Rajchgot
Harkamal Randhawa
The Hospital for Sick Children 2007-08 ANNUAL REPORT 141
HONOURS AND AWARDS
Weinstein M: James C. Fallis Teaching Award, Invited
Beck C, Parkin P, Friedman JN: Pediatric hospitalist
Bernstein S: WT Aikins Award for Individual Teaching
Speaker, Division of Paediatric Emergency Medicine,
medicine: an overview and a perspective from Toronto,
Performance, University of Toronto, 2008.
The Hospital for Sick Children, 2008.
Canada. Clinical Paediatrics 2008: 47(6): pp 546-548.
Cohen E: Harry Bain Award for excellence in teaching
PUBLICATIONS
Beck CE: Hypotonic versus isotonic maintenance
by a full-time member of the Department of
Agha M, Glazier R, Guttmann A: Social inequalities
intravenous fluid therapy in hospitalized children:
Paediatrics, University of Toronto, 2008.
affect ambulatory care sensitive hospitalizations
a systematic review. Clinical Pediatrics 2007: 46:
for up to nine years among children born in a major
pp 764-770.
Feldman M: Co-winner of the St. Joseph’s Health Centre
Canadian urban centre. Ambulatory Pediatrics
interdepartmental Best Clinical Teacher Award, 2007.
2007: 7: pp 258-262.
Bismilla Z, Sell E, Donner E: Hashimoto’s encephalopathy.
Journal of Child Neurology 2007: 22(7): pp 341-346.
Lansang P, Pope E, Weinstein M: Alvin Jacobs’
Aljaser F, Weinstein M: A one-week-old newborn with
Resident/Fellow Research Award. Growth outcomes
hypercalcemia and palpable nodules: subcutaneous
Chiu PL, Azzie G, Hilliard RI, Fecteau A: Experience
of infants with hemangiomas treated with systemic
fat necrosis. Canadian Medical Association Journal
of moral distress among pediatric surgery trainees.
steroids. Society for Pediatric Dermatology Annual
2008: 178(13):1653-4.
Journal of Pediatric Surgery 2008: 43(6): pp 986-993.
Meeting, Chicago, IL, 2007.
Au H, Harrison M, Ahmet A, Orsino A, Beck CE,
Cohen E, Friedman J, Nicholas D, Adams S,
Lau E: Undergraduate Community Paediatric Teaching
Tallett S, Gans M, Birken CS: Residents as Health
Rosenbaum P: A home for medically complex children:
Award, Department of Paediatrics, University of
advocates: the development, implementation
the role of hospital programs. Journal for Healthcare
Toronto, 2008.
and evaluation of a child advocacy initiative at the
Quality 2008: 30: pp 7-15.
University of Toronto. Paediatrics and Child Health
Pope E: Promoted to Associate Professor, Department
Cohen E, Navarro O: Silent aspiration. Pediatrics
2007: 12: pp 567-571.
in Review 2007: 28: pp 419-425.
of Paediatrics, University of Toronto, 2008.
Barrera M, D’Agostino N, Schneiderman G, Tallett S,
Tallett S: The Mickles Fellowship Award,
Spencer L, Jovcevska V: Patterns of parental
Cohen E, Weinstein M, Fisman DN: Cost effectiveness
University of Toronto, 2007.
bereavement following the loss of a child and related
of competing strategies for the treatment of pediatric
factors. OMEGA 2007: 55(2): pp 145-167.
empyema. Pediatrics 2008: 121: pp e1250-e1257.
Dr. Douglas Campbell
Dr. Carlos E. Contreras
Dr. Leona Fishman
Dr. John S. Freedman
Dr. Lee Ann Gallant
Dr. Beth D. Gamulka
Dr. Rose Geist
Dr. Golda Milo-Manson
Dr. Jay D. Rosenfield
Dr. Suzanne Schuh
Dr. Jeffrey J. Weisbrot
Dr. Sheldon A. Wise
Dr. Rahul Saxena
Dr. Clive J. Schwartz
Dr. David H. Shawn
Dr. Angelo Simone
Dr. William Gary Smith
Dr. Joseph Telch
Dr. Guy Widrich
Dr. Peter D. Wong
Dr. Heather Yang
CROSS-APPOINTEES
Dr. Glen B. Berall
Dr. Alan Berzen
Dr. Bonnie J. Cameron
142 The Hospital for Sick Children 2007-08 ANNUAL REPORT
Dr. Sabine R. George
Dr. Nicole G. Inch
Dr. D. Anna Jarvis
Dr. Ian C. Kitai
Dr. Leo Levin
Dr. Patricia M. Linders
Dr. John S. Lovering
HONORARY
Dr. Lionel B.H. Boxall
Dr. Andrew Chlebus
Dr. William Davidson
Dr. Till A. Davy
Dr. Gordon J. Donsky
Dr. James Dorey
Cohen E, Zlotnik-Shaul R: Beyond the therapeutic
Ipp M, Taddio A, Sam J, Goldbach M, Parkin PC:
Mahant S, Peterson R, Campbell M, MacGregor DL,
orphan: children and clinical trials. Pediatric Health
Vaccine-related pain: randomised controlled trial
Friedman JN: Reducing inappropriate hospital days on
(invited submission) 2008: 2(2): pp 151-161.
of two injection techniques. Archives of Diseases
a general paediatric inpatient unit. Pediatrics 2008:
of Childhood 2007: 92: pp 1105-1108.
121:(5): e1068-e1073.
Kanani R, Mohamed M: Case 1: the case of the
Metry DW, Siegel DH, Cordisco MR, Pope E,
Finan E, Mak W, Bismilla Z, McNamara PJ: Early
discontinuation of intravenous prostaglandin E(1)
after balloon atrial septostomy is associated with
irritable nephritic. Paediatrics and Child Health 2008:
Prendiville J, Drolet BA, Horii KA, Stein SL, Frieden IJ:
an increased risk of rebound hypoxemia. Journal
13(2): pp121-122.
A comparison of disease severity among affected
male versus female patients with PHACE syndrome.
of Perinatology 2008: 28(5): pp 341-346.
Lam J, Pope E: Pityriasis lichenoides and cutaneous
The Journal of the American Academy of Dermatology
Guttmann A, Manuel D, Stukel T, DeMeules M, Cernat
T-cell lymphoma in paediatrics. Current Opinion in
2008: 58(1): pp 81-87.
G, Glazier R: Immunization coverage among young
Pediatrics 2007: 19(4): pp 441-445.
O’Brodovich H, Beyene J, Tallett S, MacGregor D,
children of immigrant mothers in Ontario, Canada.
Ambulatory Pediatrics 2008: 8(3): pp 205-209.
Guttmann A, Zagorski B, Austin P, Schull M, Razzaq A,
Maguire J, DeVeber G, Parkin PC: The association
Rosenblum N: Performance of a career development
between iron deficiency anaemia and stroke in young
and compensation program at an academic health
children. Pediatrics 2007: 120: pp 1053-1057.
science centre. Pediatrics 2007: 119: pp e791-e797.
To T, Anderson G: Effectiveness of emergency
department asthma management strategies on return
visits in children: a population-based study. Pediatrics
2007: 120: pp e1402-e1410.
Hawkes M, Kitai I, Blaser S, Cohen E, Bitnun A,
Dr. Stacey Bernstein and team
Fluss J, Tran D: Neuroimaging findings in isoniazid
toxicity, presumed intramyelinic edema. European
Journal of Pediatric Neurology 2008: February 1
[Epub ahead of print].
Dr. Katy Driver
Dr. Andrew D. Duic
Dr. Anthony S.R. Duke
Dr. Thomas J. Egan
Dr. Robert Farber
Dr. Hyder H. Fazal
Dr. William Feldman
Dr. Adelaide L. Fleming
Dr. Raphael Folman
Dr. Katerina Haka-Ikse
Dr. William B. Hanley
Dr. Dirk W. Huyer
Dr. Jaya Islur
Dr. Martin H. Kosoy
Dr. Howard M. Langer
Dr. Michael Lester
Dr. David C. Maresky
Dr. Marcellina Mian
Dr. Gilbert Miller
Dr. Janette A. Milne
Dr. Paul Munk
Dr. John D.M. Murray
Dr. Jack Newman
Dr. Raymond C.W. Ng
Dr. Evangelia Papadouris
Dr. Helene A. Richards
Dr. Chandrakant P. Shah
Dr. Donald Stewart
Dr. Peter G. Strachan
Dr. Robert E. Sutton
Dr. Martin G. Wolfish
FELLOWS
Dr. Sara Abed
Dr. Alexandra Balma-Mena
Dr. Zia Bismilla
Dr. Malini Dave
Dr. Irene Lara Corrales
Dr. Perla Lansang
Dr. Jonathon Maguire
Dr. Michael McNeely
Dr. Ma. Lourdes Palmero
The Hospital for Sick Children 2007-08 ANNUAL REPORT 143
O’Connor D, Khan S, Vaughan J, Weishuhn K, Jefferies
Tallett S, Lingard L, Leslie K, Pirie J, Jefferies A, Spero
Friedman JN, Saunders NR: Canada’s Baby Care Book.
A, Campbell D, Asztalos E, Feldman M, Rovet J,
L, Schneider R, Hilliard R, Rosenfield J, Hellmann J,
Robert Rose Publishing, Toronto, 2007.
Westall C, Whyte H: Growth and nutrient intakes
Mian M, Hurley J: Measuring educational workload.
of human milk-fed premature infants provided with
Medical Teacher 2008: 30(3): pp 296-301.
Friedman JN: Technologic devices in the medically
complex child. In: Comprehensive Pediatric Hospital
extra energy and nutrients after hospital discharge.
Pediatrics 2008: 121: pp 766-776.
Wendtlandt K, Beck CE: A child with gastrointestinal
Medicine (Zaoutis LB, Chiang VW, eds.). Elsevier
bleeding. Paediatrics and Child Health 2007: 12:
Science, Philadelphia, 2007.
Seltz LB, Kanani R, Zamakhshary M, Chiu PPL: A
pp 869-870.
Landrigan C, Friedman JN: Patient safety and medical
newborn with chylous ascites caused by intestinal
malrotation associated with heterotaxia syndrome.
BOOKS AND BOOK CHAPTERS
errors. In: Comprehensive Pediatric Hospital Medicine
Pediatric Surgical International 2008: 24: pp
Adams SL, Mahant S: Introduction to the medically
(Zaoutis LB, Chiang VW, eds.). Elsevier Science,
633-636.
complex child. In: Comprehensive Pediatric Hospital
Philadelphia, 2007.
Medicine (Zaoutis LB, Chiang VW, eds.). Elsevier Inc,
Serletis D, Bouffet E, Parkin P, Rutka J, Drake J, Shroff
Weinstein M: Lower respiratory tract infections.
Philadelphia, 2007.
M: Massive plexiform neurofibromas in childhood:
In: Comprehensive Pediatric Hospital Medicine
natural history and management issues. Journal of
Bernstein S: Systemic lupus erythematosus. In:
(Zaoutis LB, Chiang VW, eds.). Elsevier Science,
Neurosurgery 2007: 106(5 Suppl): pp 363-367.
Comprehensive Pediatric Hospital Medicine (Zaoutis L,
Philadelphia, 2007.
Chiang V, eds.). Elsevier Inc., Philadelphia, 2007.
RESEARCH FUNDING
Taddio A, Manley J, Potash L, Ipp M, Sgro M, Shah V:
Routine immunization practices: use of topical
Friedman JF, Beck CE: Parenteral fluid therapy for
An exclusively community-based clerkship in
anaesthetics and oral analgesics. Pediatrics 2007:
infants and children. In: Conn’s Current Therapy
paediatrics compared with a paediatric academic
120: pp 630-631.
2008 (Rakel RE, Bope ET, eds.). Elsevier Inc.,
health science centre. Feldman M. Paediatric
Philadelphia, 2008.
Consultants Partnership’s Grant ($5,000 2007-2008)
Dr. Adam Rapoport
Dr. Leonard Barry Seltz
Dr. Navneet Sharma
Research Associates
Deepa Dalal
Spring Holter
Vesna Jovcevska
Amina Khambalia
Kayi Li
Noorulain Malik
Magda Mekky
Dr. Jyothi Sehgal
Kathryn (Kate) Smith
Vineet Syan
144 The Hospital for Sick Children 2007-08 ANNUAL REPORT
Catherine Wong
Ming Yang
ADMINISTRATIVE STAFF
Sarah Ahmad
Tiziana Altobelli
Josie Marcantonio
Marg Mather
Daffodil Morrison
Kathryn Robertson
Pauline Smith
Jan White
Donna Whitely
A prospective study on the age of onset, incidence,
CIHR Emerging Team in Childhood Obesity Research.
Evaluation of the efficacy and safety of imiquimod 5%
geographic distribution and risk factors associated
McCrindle B, Parkin P, Pencharz P, Hamilton J,
topical cream in plaque morphea: a prospective,
with atopic dermatitis. Pope, E, Krafchik BR, Pelletier J.
Anderson G, Birken C, Wells G, Riddell M, Hanley A,
multiple baseline, open label pilot study. Pope E, Laxer
Canadian Dermatology Foundation ($35,000
O’Connor D, Dettmer E, Bellisimo N, Langer J, Tein I.
R, Doria A, Feldman B, Babyn P: 3M Inc/Graceway
1996-2007)
Canadian Institutes of Health Research ($2,452,522
Pharmaceuticals Canada ($29,500 2005-2008)
2008-2013)
Evaluation of the emergency department general
A randomized, prospective, double-blind placebocontrolled clinical study assessing the efficacy
Complementary medicine in Canadian paediatric
internal medicine patient flow toolkit. Schull M,
of topical tacrolimus 0.1% ointment and topical
patients with atopic dermatitis: a cross-sectional
Guttmann A. Ministry of Health and Long-Term Care
clobetasol propionate 0.05% ointment in the
survey. Weinstein M, Pope E, Redlick F. Canadian
($1,133,400 2007-2011)
treatment of vitiligo. Ho N, Krafchik BR, Pope E,
Dermatology Foundation ($10,000 2006-2008)
Examining the impact of primary care reform in
Greenberg S, Webster C, Weinstein M. Fujisawa
Developing quality and safety indicators for Canada’s
Ontario on access to and quality of care. Glazier R,
emergency departments. Schull M, Guttmann A.
Guttmann A. Canadian Institutes of Health Research
Canadian Institutes of Health Research ($20,000 2008)
($833,400 2008-2011)
Birken CS, Beck CE, McCrindle B, Parkin PC.
Does the order in which vaccines are administered
Genetic analysis of PHACE(S) association. An
Paediatric Consultants Partnership’s Grant ($9,975
affect pain response? A randomized, double-blind,
international registry based out of the University of
clinical trial of Pentacel versus Prevnar. Ipp M, Taddio
California, San Francisco. Frieden IJ, Pope E, Siegel D:
Canada Inc. ($62,425 2004-2007)
An office based intervention to improve media use
in preschool children: a randomized controlled trial.
2007-2008)
Career enhancement. Guttmann A Canadian Child
A, Lear N, Goldbach M, Parkin PC. Sanofi Pasteur
University of Southern California at San Francisco
($17,250 2006-2007)
($20,000 2006-2009)
Health Clinician Scientist Program ($25,000
2007-2012)
Emergency department rapid intravenous rehydration
Image guided GJ-tube versus laparoscopic nissen
(RIVR) for paediatric gastroenteritis: a randomized
fundoplication with gastrostomy in neurologically
controlled trial. Freedman SB, Parkin P, Willan AR,
impaired children with gastroesophageal reflux: a
Schuh S. Physicians’ Services Incorporated
study examining health-related quality of life. Langer
Foundation ($156,000 2006-2008)
JC, Mahant S, Connolly B, Friedman JN, Nicholas D,
Wales P, Ungar W, Pastor A. Ontario Federation for
Cerebral Palsy ($29,097 2007-2009)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 145
Impact of oximetry on hospitalization in acute
Low versus high fidelity simulation in neonatal
Nutritional education and the prevention of iron
bronchiolitis. Schuh S, Freedman S, Coates A,
resuscitation training. Whyte H, Bismilla Z, Finan E,
depletion in children nine months to two years:
Parkin PC, Allen U, Willan A, Ungar W, Da Silva Z.
McNamara P. Paediatric Consultants Partnership’s
a randomized controlled trial. Parkin PC, Maguire J,
Physicians’ Services Incorporated Foundation
Grant ($5,000 2007-2008)
Khambalia A, Jacobson S, Peer M. Danone Institute
($61,148 2006-2008)
($163,000 2007-2009)
Magnesium for Sickle Cell Trial (MAST). Goldman R,
International registry of paediatric cutaneous T-cell
Mounstephen W, Kirby M, Friedman JN. Physicians’
Open label extension study to determine safety
lymphoma: a longitudinal, prospective, observation
Services Incorporated Foundation ($163,846
of etanercept in paediatric subjects with plaque
study of cutaneous T-cell lymphoma in the paediatric
2005-2008)
psoriasis. Pope E, Weinstein M. Amgen Inc.
($43,000 2006-2007)
population. Pope E, Weinstein M, Weitzman S, Taylor G.
Canadian Dermatology Foundation ($10,000
Measuring the quality of hospital care for children
2004-2009)
and youth in Canada. Guttmann A, Matlow A, Moore C,
Parshuram C, Stukel T, To T. Canadian Institutes
NF1-associated malignancy. Lewis S, Parkin P.
International registry of paediatric cutaneous T-cell
of Health Research ($25,000 2007-2010)
The Hospital for Sick Children Research Institute
Palindromy at the NF1 locus as a risk factor for
New Ideas Grant ($45,023 2006-2009)
lymphoma: a longitudinal, prospective, observation
study of cutaneous T-cell lymphoma in the paediatric
Measuring the quality of hospital care for children
population. Pope E. University of Toronto Dean’s
and youth in Canada. Guttmann A. Ontario Ministry of
Paediatric outcomes research. Parkin PC, Macarthur C.
Fund New Staff Grants ($10,000 2004-2009)
Health and Long-Term Care ($300,000 2007-2010)
SickKids Foundation ($750,000 2008-2012)
Is prolonged bottle feeding an independent risk for
Measuring the quality of hospital care for children
Pilot study of a lifestyle program in children receiving
overweight in young children? Birken CS, Parkin PC,
and youth in Canada. Guttmann A. Canadian
treatment for acute lymphoblastic leukaemia (ALL).
O’Connor D, Jacobson S, Peer M, Mekky M. University
Institutes of Health Research ($75,000 2008-2011)
Nathan P, Wright M, Collins L, Birken CS, Dettmer E.
Modifiable risk factors for acute chest syndrome in
Grant ($14,000 2008-2009)
Paediatric Oncology Group of Ontario Seed Funding
of Toronto Dean’s Fund New Staff ($9,972 2008-2013)
Isotonic versus hypotonic IV maintenance fluid in
children with sickle cell disease admitted to hospital
children: a randomized controlled trial. Friedman JN.,
with a painful crisis. Birken CS, Khambalia A, Dekker
Freedman S, Beck C, Geary D. Paediatric Consultants
A, Pastor A, Lee M, Padavattan K, Parkin PC. Paediatric
Partnership’s Grant ($9,956 2007-2008)
Consultants Partnership’s Grant ($3,750 2007-2008)
146 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
The efficacy of trimethoprim in wound healing of
Presentation, management and outcomes evaluation
Teaching intubation to residents: standard mannequin
of children with vascular tumours. (Vascular
versus high fidelity simulation. Whyte H, Bismilla Z,
patients with epidermolysis bullosa: a randomized
Tumour Registry). Pope E, Mahant S, Blanchette V,
Finan E, Jefferies A, LeBlanc V. Physicians’ Services
double-blinded, placebo-controlled, cross-over pilot
Weitzman S, Baruchel S, John P, Brandao L. Paediatric
Incorporated Foundation ($17,000 2007-2008)
study. Pope, E, Lara-Corrales I, Weinstein M, Parkin P,
Sibbald G. Canadian Dermatology Foundation
Consultants Partnership’s Grant ($9,900 2006-2009)
The effectiveness of the paediatric sedation device:
($10,000 2007)
Genetic determinants of influenza severity in children:
pilot study for randomized controlled trial. Brown SC,
A pre-pandemic community-based feasibility study.
Schneeweiss S, McGrath PA, Pope E. National
Treatment choices for children with typical acute
Tran D, Beyene J, Bitnun A, Paterson A, Richardson S,
Institutes of Health ($159,062 2005-2008)
immune thrombocytopenic purpura: development
of a decision aid. Beck C, Birken CS, Blanchette V,
Ipp M. Canadian Institutes of Health Research
($99,919 2008-2009)
The efficacy of trimethoprim in wound healing of
Boydell K, Llewellyn-Thomas H, Parkin PC. University
patients with epidermolysis bullosa: a randomized,
of Toronto Dean’s Fund New Staff Competition
($10,000 2006-2011)
Short- and long-term outcomes of complicated
double-blinded, placebo-controlled, cross-over pilot
paediatric pneumonia. Weinstein M, Cohen E, Dell S,
study. Pope E, Lara-Corrales I, Weinstein M, Parkin P,
Mahant S, Traubici J, Mekky M. University of Toronto
Sibbald G. Dystrophic Epidermolysis Bullosa
Dean’s Fund New Staff Grant ($10,000 2007-2008)
Waiting with an emergency. Schull M, Guttmann A.
Recessive Association of Canada (dEBra Canada)
Canadian Health Services Research Foundation
($10,000 2006-2008)
($400,000 2007-2010)
Sickle cell disease in children: osteomyelitis or
vaso-occlusive crises? Berger E, Saunders N,
Khambalia A, Friedman JN. SickKids Trainee
Start-up Fund ($3,000 2007-2008)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 147
Division of
Dr. Theo Moraes
DIVISION HEAD
Dr. Felix Ratjen
FULL-TIME
Dr. Allan L Coates
Dr. Sharon Dell
Dr. Hartmut Grasemann
Dr. Indra Narang
Dr. Melinda Solomon
Dr. Padmaja Subbarao
Dr. Neil B Sweezey
PART-TIME
Dr. Peter Bikangaga
Dr. James MacFarlane
Dr. Theo Moraes
Dr. Charlotte D’E. Miller
ADJUNCT SCIENTIST
Dr. Hiran Selvadurai
CROSS-APPOINTEES
Dr. T. Douglas Bradley
Dr. Theodore Marras
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
HONORARY FACULTY
Dr. Dennis Gurwitz
Dr. Elizabeth Tullis
FELLOWS
Dr. Dimas Mateos-Corral
Dr. Harutai Kamalaporn
Dr. Mustafa Osman
Dr. Reshma Amin
Dr. Sintra Phumethum
Dr. Suhail Al-Saleh
SUBSPECIALTY RESIDENTS
Dr. Joanna Swinburne
Dr. Tania Samanta
Dr. Tara Allen
ADMINISTRATIVE STAFF
Tara Beattie
Jennifer Chay
Victoria Snell
Division of Respiratory Medicine
OVERVIEW
As part of the Toronto Lung Transplantation Program,
inflammation and infection in cystic fibrosis, effect of
The Division of Respiratory Medicine continues to
the division provides pre- and post-transplantation
sex hormones in airway inflammation, defining the role
provide comprehensive care for the full range of
care for children with end-stage lung disease. The
of novel genes in lung development, studies in aerosol
paediatric pulmonary diseases such as asthma, cystic
lung transplant program continues to be the largest
therapy and exercise physiology. Dr. Subbarao has
fibrosis (CF), interstitial lung fiseases, primary ciliary
paediatric lung transplant program in the country.
become the co-principal investigator of a large birth
cohort study to elucidate the factors important for the
dyskinesia (PCD), hereditary hemorrhagic telangiectasia
(HHT), sleep-related disorders of breathing and complex
The training program has independent Royal College
development of asthma in early childhood that is
respiratory care requiring ventilatory support, as well as
of Physicians and Surgeons of Canada accreditation
supported by CIHR and partners such as AllerGen.
children with congenital malformations involving the
and is the largest training program for paediatric
respiratory tract. We provide consultation support for
respiratory medicine in the country. It provides the full
the hospital in all areas of paediatric respiratory
range of training that is required for board certification
NIH-funded childhood asthma management program
disease. The division provides diagnostic services
in paediatric pulmonology in the United States. As well
continuation study (Dr. Grasemann, Dr. Subbarao).
including flexible bronchoscopy.
as offering training to Royal College of Physicians and
There has also been a growing interest in assessing
Over the last year, we have broadened our diagnostic
The division also continues to be involved in the
Surgeons of Canada eligible candidates, the division
the pulmonary sequelae of sickle cell disease that are
also trains physicians from abroad.
currently being addressed in a number of research
studies (Dr. Grasemann, Dr. Narang, Dr. Subbarao).
spectrum of tests to assess diseases with airway
inflammation, including testing of nitric oxide in
Dr. Theo Moraes, who completed his PhD in Dr. Gregory
Dr. Allan Coates and Laura Seed have been very active
exhaled air as well as gas mixing techniques as more
Downey’s laboratory and subsequently worked with
on both the provincial and national level with the
Ontario Lung Association and the Canadian Thoracic
sensitive tests for obstructive airway diseases. The
Dr. Tanja Watts, has joined our division as a clinician-
addition of an infant pulmonary function laboratory
scientist. His research is directed towards a better
Society by promoting training of spirometry in children
has broadened the potentials for diagnostic tools to
understanding of processes driving lung inflammation,
and acting in advisory roles for research studies using
objectively assess lung disease in infants and young
as well as immunological mechanisms involved in
lung function testing with Statistics Canada.
children, and is available for the assessment of both
immunity against respiratory viruses. There is a broad
inpatients and outpatients. The infant pulmonary
spectrum of both basic science and clinical research
function lab is the only laboratory in the country
that bridges the laboratory to the clinic in many
offering this service. We are currently in the process
disease areas. The major research foci include clinical
of closing the gap by developing pulmonary function
and epidemiological studies in patients with asthma
tests for preschool children as well.
and cystic fibrosis, translational studies on airway
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 149
Dr. Dell is involved in an international program to
Dr. Ratjen and the CF group are involved in multiple
For a more complete description of our clinical activities,
develop a new classification for interstitial lung
studies in a leading role, including multicentre studies
educational events and research interests, please visit
diseases and a NIH-sponsored study on primary ciliary
on azithromycin in Pseudomonas negative CF patients.
the division of respiratory medicine website as well as
dyskinesia. Dr. Dell, in collaboration with researchers
This is the first Canada-U.S. study funded by the U.S.
the website CF centre.
from the University of California in Berkeley, is also
CF foundation on the role of aspergillus infection in CF.
leading a study examining the association between
Funded by the Canadian CF foundation and Physicians’
PUBLICATIONS
asthma and traffic-related air pollution in Toronto
Services Incorporated Foundation and on the use of
Al-Saleh S, Grasemann H, Cox P: Necrotizing pneumonia
school-age children. Dr. Solomon is studying the
hypertonic saline as an early intervention strategy
complicated by early and late pneumatoceles. Canadian
cognitive-behavioural aspects of teaching communication
funded by the US CF foundation and the NIH. Dr.
Respiratory Journal 2008: 15: pp 129-132.
supported by an educational development grant from
Grasemann is leading a series of studies to elucidate
the Centre of Faculty Development.
the role of arginase and NO deficiency in CF lung disease
Amin R, Ratjen F: MRI: the next frontier for cystic
sponsored by CIHR and the Canadian CF foundation.
fibrosis clinicians? Expert Review of Respiratory
In addition, members of the division are key partners of
Medicine 2008: 2(2): pp 179-182.
the CF team that has formed the Cystic Fibrosis Centre,
The division is also involved in developing new
highlighting the longstanding and ongoing excellence in
outcomes measures to assess improvement in CF
Belik J, Shehnaz D, Pan J, Grasemann H:
both clinical care and research at SickKids in this area.
lung disease within the BREATHE program, a study
Developmental changes in arginase expression
Newborn screening for cystic fibrosis was started this
to develop CFTR corrector therapy (Dr. Ratjen). Other
and activity in the lung. American Journal
year and the CF team at SickKids was a driving force
studies supported by research grants, as well as
of Physiology–Lung, Cellular and Molecular
Physiology 2008: 294: pp L498-L504.
in getting this off the ground. Dr. Ratjen acts as a
generous support by individuals such as the Irwin
medical advisor to the screening group in Ottawa and
family, are ongoing, in addition to industry sponsored
a collaborative study with Dr. Durie as the principal
studies. One is an 80-site study on denufosol, a P2Y
Brenden C, Danziger-Isakov LA, Astor T, Aurora P,
investigator will be started to evaluate the clinical
receptor agonist that activates chloride conductance
Bluemchen K, Boyer D, Conrad C, Eichler I, Elidemir O,
course of patients with an unclear diagnosis within
through alternative chloride channels (Dr. Ratjen, PI).
Goldfarb S, Michaels MG, Mogayzel PJ, Mueller C,
the Newborn Screening Program.
The CF group is also involved in other clinical studies
Parakinikas D, Oberkfell D, Solomon M, Boehler A:
of drugs targeting the basic defect in CF. A close
Variability in immunization guidelines in children
collaboration exists with the adult CF program at St.
before and after lung transplantation. Pediatric
Michael’s Hospital led by Dr. Tullis, in both clinical
Transplantation 2007: 11: pp 882-887.
care and many areas of research, and with the Lung
Transplant Team at Toronto General led by Dr. Keshavjee.
150 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Grasemann H, Gerard NP, De Sanctis GT: Ventilatory
Coates AL, Green M, Leung K, Louca E, Tservistas M,
Dell SD, Becker A, Chapman K, Foty R, Franssen E:
Chan J, Ribeiro N, Charron M: The challenges of
Are symptom-based criteria enough to define asthma
responses to acute hypoxia in neurokinin-1 receptor
quantitative measurement of lung deposition using
control in children? A population-based cross-
deficient mice. Respiratory Physiology and
Neurobiology 2007: 159: pp 227-231.
99mTc-DTPA from delivery systems with very different
sectional analysis comparing adult and pediatric
delivery times. Journal of Aerosol Medicine 2007:
asthma outcomes. Pediatric Pulmonology 2007:
20: pp 320-330.
42: pp 1117-1124.
Lakeman P, Gille JJP, Dankert-Roelse JE, Heijerman
Coates AL: Guiding aerosol deposition in the lung.
Deutsch GH, Young LR, Deterding RR, Fan LL, Dell SD,
Cornel MC, ten Kate LP: CFTR mutations in Turkish
New England Journal of Medicine 2008: 358:
Bean JA, Brody AS, Nogee LM, Trapnell BC, Langston
and North African cystic fibrosis patients in Europe:
HGM, Munck A, Iron A, Grasemann H, Schuster A,
pp 304-305.
C, and the Pathology Co-operative Group: Diffuse lung
implications for screening. Genetic Testing 2008:
disease in young children: application of a novel
12: pp 25-35.
Coates AL, Green M, Leung K, Chan J, Ribeiro N, Louca
classification scheme. American Journal of Respiratory
E, Ratjen F, Charron M, Tservistas M, Keller M: Rapid
and Critical Care Medicine 2007: 176: pp 1120-1128.
Nikolaizik WH, Vietzke D, Ratjen F: A pilot study to
compare tobramycin 80 mg injectable preparation
pulmonary delivery of inhaled tobramycin for
Pseudomonas infection in cystic fibrosis: a pilot project.
Duong M, Subbarao P, Adelroth E, Otis J, Obminski G,
with 300 mg solution for inhalation in cystic fibrosis
Pediatric Pulmonology 2008: 43(8): pp 753-759.
Strienich T, Inman M, Pedersen S, O’Byrne PM:
patients. Canadian Respiratory Journal 2008: 15(5):
Sputum eosinophils and the response of exercise-
pp 259-262.
Corral DM, Coates AL, Yau YC, Tellier R, Glass M,
induced bronchoconstriction to corticosteroid in
Jones SM, Waters VJ: Burkholderia pseudomallei
asthma. Chest 2008: 133(2): pp 404-411.
Narang I, Rosenthal M, Bush A: Reproducibility of
cardioventilatory measurements using a respiratory
infection in a cystic fibrosis patient from the
Caribbean: a case report. Canadian Respiratory
Grasemann C, Ratjen F, Reutershahn E, Vester U,
mass spectrometer. Respiratory Physiolology &
Journal 2008: 15(5): pp 237-239.
Schnabel D, Grasemann H: Effect of growth hormone
Neurobiology 2007: 157: pp 310-315.
therapy on nitric oxide formation in patients with
Davis SD Ratjen F: Editorial: Reduced lung function in
cystic fibrosis. European Respiratory Journal 2008:
Nemati B, Atmodjo W, Kaplan F, Sweezey NB:
cystic fibrosis: a primary or secondary phenotype?
4: pp 815-821.
Glucocorticoid receptor disruption delays structural
American Journal of Respiratory and Critical Care
maturation in the lungs of newborn mice. Pediatric
Medicine 2008: 178(1): pp 2-3.
Pulmonology 2008: 43(2): pp 125-133.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 151
Quinlan J, Kaplan F, Sweezey NB, Goodyer P: LGL1,
Stanojevic S, Wade A, Stocks J, Hankinson J, Coates
Waters V, Ratjen F: Combination antimicrobial
a novel branching morphogen in developing kidney,
AL, Pan H, Rosenthal M, Corey M, Lebecque P, Cole
susceptibility testing for acute exacerbations in
is induced by retinoic acid. American Journal of
TJ: Reference ranges for spirometry across all ages:
chronic infection of Pseudomonas aeruginosa in
Physiology - Renal Physiology 2007: 293(4):
a new approach. American Journal of Respiratory and
cystic fibrosis. Cochrane Database Systematic
pp F987-F993.
Critical Care Medicine 2008: 177: pp 253-260.
Reviews 2008: 3: CD006961.
Ratjen F: Aerosol therapy in cystic fibrosis:
Subbarao P, Balkovec S, Solomon M, Ratjen F: Pilot
Wells G, Wilkes D, Schneiderman-Walker J, Elmi M,
weighing the evidence. Pediatric Pulmonology
study of safety and tolerability of inhaled hypertonic
Tullis E, Ratjen F, Coates AL: Reliability and validity
2008: 43(S9): pp S3-S4.
saline in infants with cystic fibrosis. Pediatric
of the habitual activity estimation scale (HAES) in
Pulmonology 2007: 42: pp 471-476.
Current Opinion in Pulmonary Medicine 2007: 13(6):
pp 541-546.
Ratjen F: Recent advances in cystic fibrosis. Paediatric
patients with cystic fibrosis. Pediatric Pulmonology
2007: 43: pp 345-353.
Ratjen F: New pulmonary therapies for cystic fibrosis.
To T, Dell S, Dick P, Cicutto L: The burden of illness
experienced by young children associated with
BOOKS AND BOOK CHAPTERS
asthma: a population-based cohort study. Journal
Narang I, Balfour-Lynn I: Cardiopulmonary function
of Asthma 2008: 45(1): pp45-49.
testing–paediatrics. In: Physiotherapy for Respiratory
Respiratory Reviews 2008: 9(2): pp 144-148.
and Cardiac Problems, 4th Edition (Pryor J, Prasad A,
To T, Gershon A, Wang C, Dell S, Cicutto L: Persistence
Ridder-Schaphorn S, Ratjen F, HГјbbers A, HГјberte J,
and remission in childhood asthma: a population-based
Falk S, Küster P, Schuster A, Mellies U, Löwe B,
asthma birth cohort study. Archives of Pediatrics and
Reintjes R, Peters G, Kahl BC: Nasal staphylococcus
Adolescent Medicine 2007: 161(12): pp 1197-1204.
aureus carriage is not a risk factor for lower airway
eds.). Churchill Livingstone, Oxford, UK, 2008.
Ratjen F, Tullis E: Cystic fibrosis. In: Clinical
Respiratory Medicine, 3rd Edition (Albert RK, Spiro SG,
Jett JR, eds.). Mosby Elsevier, St. Louis, MO, 2008.
infection in young cystic fibrosis patients. Journal of
Clinical Microbiology 2007: 45(9): pp 2979-2984.
Solomon M, Ross H, Delgado D. Pediatric lung
transplantation. In: Lung Transplantation Manual
(Chaparro Mutis C, Hutcheon M, Singer L, Keshavjee
S. eds.). Elsevier, Toronto, 2007.
152 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
FUNDING
CAMP-CS3: The Hospital for Sick Children Clinical
Effect of increased L-arginine bioavailability on
A multi-stage population based study to determine
Centre for Study of a Childhood Asthma Management
cystic fibrosis lung disease. Grasemann H, Ratjen F,
the association between air pollution and asthma.
Program - continuation study, part 3. Subbarao P,
Pencharz P, Scott J. Canadian Cystic Fibrosis
Dell S. Health Canada ($79,000 2007-2009)
Grasemann H, Solomon M. John Hopkins University
Foundation ($39,869 2007-2009)
Centre for Clinical Trials/National Institutes of
A pilot study to evaluate the tolerability of inhaled
Effect of increased L-arginine bioavailability on
Health National Heart, Lung and Blood Institute
7% hypertonic saline in infants with cystic fibrosis
cost-reimbursement contract grant (US$370,633
Pseudomonas aeruginosa infection of the lung in
(ISIS-001). Ratjen F. US CF Foundation ($10,878
2008-2011)
cystic fibrosis. Grasemann H, Ratjen F, Pencharz P,
Scott J. Canadian Institutes of Health Research
2007-2008)
Canadian birth cohort: Indoor air and the development
($100,000 2007-2009)
A randomised double-blind, placebo-controlled
of asthma and allergy (CHILD study). Sears M,
four-way cross over study comparing montelukast,
Subbarao P. Canadian Institutes of Health Research
Effect of Ontario’s universal influenza immunization
inhaled budesonide and their combination to placebo
($12,000,000 2007-2013)
program on influenza-related health-care outcomes.
Characterization of factors and mechanisms affecting
($82,163 2007-2009)
Manuel D, Dell S. Canadian Institutes of Health
on exercise-induced bronchoconstriction. Grasemann
H, Subbarao P, O’Bryne P. Merck-Frosst RCT
($207,580 2007-2008)
Breathe program–a randomized-controlled trial of
physical activity, muscular function and lung health in
cystic fibrosis. Coates AL, Ratjen R. Canadian Cystic
Effect of rhDNase of ventilation in homogeneity in
Fibrosis Foundation ($180,000 2006-2008)
patients with cystic fibrosis. Ratjen F, Subbarao P.
Hoffman-La-Roche ($45,000 2007-2008)
inhaled hypertonic saline (7%) to detect a treatment
effect using the lung clearance index in CF patients
Diagnosing cystic fibrosis in neonates and adults:
with normal lung function. Ratjen F. Canadian Cystic
where do we draw the line? Durie P, Tullis E, Ratjen F.
Functional analyses of two novel, developmentally-
Canadian Cystic Fibrosis Foundation ($360,000
regulated glucocorticoid responsive genes in fetal
Fibrosis Foundation ($61,654 2007-09)
2008-2011)
CAMP-CS2: The Hospital for Sick Children Clinical
lung. Kaplan F, Sweezey N. Canadian Institutes
of Health Research ($655,595 2004-2009)
Centre for Study of a Childhood Asthma Management
Program – continuation study, part 2. Grasemann H,
Solomon M, Subbarao P. John Hopkins University
Centre for Clinical Trials/National Institutes of
Health/National Heart, Lung and Blood Institute
($631,133 2003-2007)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 153
Glucocorticoid receptor and glucocorticoid-responsive
Modulation by sex hormones of inflammation and
Multicentre, multi-national, randomized, placebo-
genes in developing lung. Sweezey N, Kaplan F.
susceptibility to Pseudomonas aeruginosa in cystic
controlled trial of azithromycin in participants with
Canadian Institutes of Health Research ($563,500
fibrosis airways. Sweezey N. Canadian Cystic Fibrosis
cystic fibrosis, six to 18 years old, culture negative for
2004-2009)
Foundation ($140,000 2007-2009)
Pseudomonas aeruginosa. Ratjen F, Solomon M.
Cystic Fibrosis Foundation Therapeutics Inc.
Inhaled saline for infants study (ISIS-002). Davis S,
Modulation by sex hormones of inflammation and
Rosenfeld M, Ratjen F. US CF Foundation (continued
susceptibility to Pseudomonas aeruginosa in cystic
($5,200,464 2006-2009)
funding guaranteed for the complete study duration of
fibrosis airways (salary support for technican).
Pharmacogenomics of P2Y2 receptor activation.
four years through CFF) (US$1,794,674 2007-2008)
Sweezey N. The Lynne and Arnold Irwin Foundation
Ratjen F. Inspire Inc. ($51, 030 2007-2009)
($40,000 2007-2009)
Respiratory population-based outcomes network:
Lab technician salary support. Grasemann H.
The Lynne and Arnold Irwin Foundation
($25,000 2007-2008)
Mucociliary Clearance Consortium, Rare Diseases
studies and evaluations (RESPONSE). To T, Dell S.
Centre. Site PI: Dell S (main PI: Knowles M, primary
Canadian Institutes of Health ($150,000 2007-2009)
site: Chapel Hill). National Institutes of Health
Long-term outcomes after paediatric complicated
($76,958 2007-2008)
and modulates NO synthesis in the cystic fibrosis lung.
pneumonia. Cohen E, Dell S. University of Toronto
Dean’s Fund ($10,000 2007-2009)
Surfactant protein D controls inflammatory response
Multicentre, multi-national, randomized, placebo-
Grasemann H (David Douda, PhD student). Ontario
controlled trial of azithromycin in participants with
Student Opportunity Trust Fund/Restracomp
($60,000 2008-2010)
Lung allograft rejection gene expression observational
cystic fibrosis, six to 18 years old, culture negative
study. Solomon M. XDx Expression Diagnostics
for Pseudomonas aeruginosa (PI salary support).
($7,500 2005-2007)
Ratjen F. Cystic Fibrosis Foundation Therapeutics Inc.
(US$36,546 2007-2008)
Mini-child lung function and biomarkers - program
A–gene environment interactions. Subbarao P.
AllerGen NCE Inc. ($215,000 2007-2009).
154 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
VX06-770-101: A phase 2a, randomized, double-blind,
The cognitive-behavioural model for teaching
Treatment of aspergillus fumigatus in patients with
communication skills: a pilot project. Solomon M.
cystic fibrosis: a randomized, double-blind, placebo-
placebo controlled study of VX770 in patients with
Educational Development Fund, University of Toronto
controlled trail. Ratjen F, Aaron S. Canadian Cystic
cystic fibrosis having g551d mutations to evaluate
($5,000 2007-2008)
Fibrosis Foundation ($220,800 2007-2010)
safety, phamacokinetics and biomarkers of CFTR
activity. Accurso F, Durie P, Ratjen F, Tullis E. Vertex
Pharmaceuticals, Inc. (US$30,000 2007-2008)
The Hospital for Sick Children Centre for the Study
Treatment of aspergillus fumigatus in patients with
of Complex Childhood Diseases (CSCCD). Post M.
cystic fibrosis: A randomized, double-blind, placebo-
Canadian Foundation for Innovation ($20,571,919
controlled trail. Ratjen F, Aaron S. Physicians’
Young infants with acute recurrent wheezing: to puff
206-2011)
Services Incorporated Foundation ($122,000
or not to puff? A randomized controlled trial.
2007-2009)
Grasemann H, Schuh S, Coates A, Willan A, Ungar W,
Training program in clinical nutrition. Pencharz P,
Dick P. SickKids Foundation/Institute of Human
Anderson H, Coates A, Darling P, O’Connor D, Archer
Development, Child and Youth Health/Canadian
M, Wolever T. Canadian Institutes of Health
Institutes of Health Research ($130,000 2008-2010)
($1,590,000 2002-2008)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 155
Bonnie Cameron
DivisionDr.of
DIVISION HEAD
Dr. Brian Feldman
FULL-TIME
Dr. Susanne Benseler
Dr. Ronald Laxer
Dr. Rayfel Schneider
Dr. Shirley Tse
Dr. Rae Yeung
MAJOR PART-TIME
Dr. Earl Silverman
Dr. Lynn Spiegel
PART-TIME
Dr. Bonnie Cameron
CROSS-APPOINTEES
Dr. Vivian Bykerk
Dr. Hans-Michael Dosch
Dr. Paul Fortin
CLINICAL FELLOWS
Dr. Clare Hutchinson
Dr. Linda Hiraki
Dr. Roman Jurencak
Dr. Sathish Kumar
Dr. Lily Lim
Dr. Marcela Pizana-Serna
Dr. Heinrike Schmeling
Dr. Elizabeth Stringer
ADMINISTRATIVE STAFF
Sandra Bergeron
Shona Magee
Roseanne Richard
Division of Rheumatology
OVERVIEW
Singapore. Paediatric rheumatology graduates have
Blankier S: First place winner, University of Toronto
The Division of Rheumatology provides comprehensive
done extremely well in obtaining academic placements
Ogryzlo Research Day for his poster presentation, The
care for children with rheumatic diseases. The
across Canada and around the world and trainees
role of atorvastatin in modulating pathogenesis in an
ambulatory clinics have approximately 5,000 patient
have been productive in the research arena.
animal model of kawasaki disease, June 2008.
well as at Bloorview Kids Rehab and the outreach
Research foci include the development of trial design
Cameron B: Claus Wirsig Humanitarian Award
clinic in Sudbury. In addition to the general rheumatology
for the study of rare diseases, outcome, prognosis and
winner, 2008.
clinics, there are unique multidisciplinary subspecialty
treatment studies in juvenile arthritis, SLE, neonatal
clinics for children with dermatomyositis, morphea,
lupus, scleroderma, dermatomyositis and vasculitis.
Hutchison C: First prize winner, University
systemic JIA and systemic lupus erythematosus. New
Basic research focuses on the immunopathogenesis
of Toronto Ogryzlo Research Day for her podium
clinics for children with central nervous system
of Kawasaki disease using an animal model.
visits per year at The Hospital for Sick Children, as
presentation, Open label study for treatment
of angiography-negative, biopsy-positive primary
vasculitis and juvenile spondyloarthropathy have been
initiated. The division makes extensive use of the
In July 2007, Dr. Rayfel Schneider was promoted to
medical day care unit, where children receive joint
Associate Chair, Education, Department of Paediatrics
injections under anaesthesia, therapeutic infusions,
and continues to work part-time as a staff rheumatologist.
Hutchinson C: Winner, American College of
or undergo investigations which would otherwise
Dr. Brian Feldman was promoted to Head of the
Rheumatology Pediatric Rheumatology Fellow Award,
require inpatient admission. An increasing number of
Division of Rheumatology and Dr. Shirley Tse was
in recognition of outstanding abstract and research
children have benefited from treatment with biologic
appointed Director of the Rheumatology Residency
accomplishments. Keystone, CO, 2008.
agents on the medical day care unit.
Training Program.
The Division of Rheumatology has the largest
HONOURS AND AWARDS
Canadian Network for Improved Outcomes in Systemic
paediatric rheumatology fellowship training program
Ardelean D: ACR REF/Abbott Medical and
Lupus Erythematosus, 2008 (Declined).
in North America and is fully accredited by the Royal
Paediatric Resident Research Award, 2007 for
College of Physicians and Surgeons of Canada. This
her research on VEGFB expression in a mouse
Hiraki L: Clinician Scientist Training Program (CSTP),
academic year, our fellows originated from Canada,
model of Kawasaki disease.
SickKids, Toronto, 2008 (Declined)
Benseler S: Clinical Recognition Award, Division
Hiraki L: Frank Knox Memorial Fellowship to conduct
of Paediatric Emergency Medicine, The Hospital
postgraduate studies in clinical epidemiology at
for Sick Children, 2007.
Harvard University.
CNS vasculitis in children, 2008.
Hiraki L: CaNIOS Kirkland Scholarship Award,
the Czech Republic, Germany, India, Mexico and
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 157
Hiraki L: Second place winner, University
Schmeling H: Winner, German Society of Pediatric
PUBLICATIONS
of Toronto Ogryzlo Research Day for her poster
Rheumatology (GKJR) Research Award at the Annual
Abrahamyan L, Feldman BM, Johnson SR, Beyen J,
presentation, Predicting macrophage activation
Meeting in Neuss, Germany, for her project, Nailfold
Shah PS: Quality of randomized clinical trials in juvenile
syndrome (MAS) in paediatric systemic lupus
capillary density is strongly associated over time
idiopathic arthritis. Rheumatology 2008: 1: p 366.
erythematosus (pSLE) parents at diagnosis, 2008.
with muscle and skin disease activity in juvenile
dermatomyositis (supervisor Dr. Brian Feldman), 2007.
Akikusa JD, Feldman BM, Gross GJ, Silverman ED,
Gladman Award for sustained and outstanding
Silverman E: Ontario Lupus Association
pulse methyprednisolone. Pediatrics 2007: 119(3):
contributions to the University of Toronto Division
HOPE Award, 2008.
pp e778-e782.
Schneider R: University of Toronto, 2007 Dafna
Schneider R: Sinus bradycardia after intravenous
of Rheumatology as Program Director, Paediatric
Rheumatology Residency Training Program.
Silverman E: Department of Paediatrics,
Akikusa JD, Schneider R, Harvey EA, Hebert D,
Nominated by Rheumatology Trainees, 2007.
University of Toronto, The Hospital for Sick Children,
Thorner PS, Laxer RM, Silverman ED: Clinical features
Subspecialty Education Award for Excellence
and outcome of pediatric Wegener’s granulomatosis.
in Clinical Teaching, 2007-2008.
Arthritis and Rheumatism 2007: 57(5): pp 837-844.
pharmacogenetics of juvenile idiopathic arthritis and
Stringer E: Completing her masters in clinical
Avcin A, Singh-Grewal D, Silverman ED, Schneider R:
juvenile dermatomyositis–The influence of single-
epidemiology and has accepted a staff position
Severe digital ischemia in a child with Wegener’s
nucleotide polymorphisms in genes coding for
at Dalhousie University, IWK Health Centre
granulomatosis. Scandinavian Journal of
metabolism pathway enzymes on the efficacy and
in the Division of Paediatric Rheumatology, 2008.
Rheumatology 2007: 36(1): pp 78-80.
Yeung R: The Arthritis Society Investigator Award,
Avcin T, Benseler SM, Tyrrell PN, Cucnik S, Silverman
Schmeling H: Postgraduate Medical Education
Research Award, the Chisholm Memorial Fellowship:
toxicity of methotrexate, 2008.
Schmeling H: Selected to participate in the Clinical
2007-2012.
ED: A follow-up study of antiphospholipid antibodies
Immunology Society (CIS) School in Systemic
and associated neuropsychiatric manifestations in
Autoimmune Diseases, Boston, 2008.
137 children with systemic lupus erythematosus.
Arthritis Care and Research 2008: 59(2): pp 206-213.
158 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Avcin T, Silverman ED: Review: antiphospholipid
Elbers J, Benseler SM: Central nervous system
Hiraki LT, Benseler SM, Tyrrell PN, Hebert D, Harvey E,
antibodies in pediatric systemic lupus erythematosus
vasculitis in children. Current Opinion in Rheumatology
Silverman ED: Clinical and laboratory characteristics
and the antiphospholipid syndrome. Lupus 2007:
2008: 20(1): pp 47-54.
and long-term outcome of pediatric systemic lupus
erythematosus. Journal of Pediatrics 2008: 152(4):
16(8): pp 627-633.
pp 550-556.
Feldman BM, Aledort L, Bullinger M, Delaney FM,
Benseler SM, Silverman ED: Neuropsychiatric
Doria AS, Funk S, Giangrande P, Lundin B, Manco-
involvement in pediatric systemic lupus
Johnson M, Miners A, Scriba PC, Sricvastava A,
Hiraki LT, Hamilton J, Silverman ED: Measuring
erythematosus. Lupus 2007: 16(8): pp 564-571.
Blanchette VS: The economics of haemophilia
permanent damage in pediatric systemic lupus
prophylaxis: governmental and insurer perspectives.
erythematosus. Lupus 2007: 16(8): pp 657-662.
Benseler SM, Silverman ED: systemic lupus
Haemophilia 2007: 13(6): pp 1-5.
Huber AM, Dugan ED, Lachenbruch PA, Feldman BM,
erythematosus. Rheumatic Disease Clinics
Perez MD, Zemel LS, Lindsley CB, Rennebohm RM,
of North America 2007: 33(3): pp 471-498.
Feldman BM, Funk S, Lundin B, Doria AS, Ljung R,
Blanchette V: Musculoskeletal measurement tools
Wallace CA, Passo MH, Reed AM, Bowyer SL, Ballinger
Boros C, Silverman ED, Spence D, Blaser S:
from the International Prophylaxis Study Group (IPSG).
SH, Miller FW, Rider LG, Juvenile Dermatomyositis
Hydrocephalus and macrocephaly: new manifestations
Haemophilia 2008: 14(Suppl): pp 162-169.
Disease Activity Collaborative Study Group: Preliminary
Gong G, Barrera M, Beyene J, Bhat S, Carcao M,
assessment tool in juvenile dermatomyositis.
Lord S, Narayanan U, Sung L, Young N, Feldman BM:
Arthritis and Rheumatism 2008: 59(2): pp 214-21.
validation and clinical meaning of the cutaneous
of neonatal lupus erythematosus. Arthritis and
Rheumatism 2007: 57(2): pp 261-266.
Brunner HI, Gladman DD, Ibanez D, Urowitz MD,
The gap study (GapS) interview - developing a process
Silverman ED: Difference in disease features
to determine the meaning and determinants of quality
Huber AM, Dugan EM, Lachenbruch PA, Feldman BM,
between childhood-onset and adult systemic lupus
of life in children with arthritis and rheumatic diseases.
Perez MD, Zemel LS: The cutaneous assessment tool:
erythematosus (SLE). Arthritis and Rheumatism
Clinical and Experimental Rheumatology 2007: 25(3):
development and reliability in juvenile idiopathic
2008: 58(2): pp 556-562.
pp 486-493.
inflammatory myopathy. Rheumatology 2007: 46(10):
pp 1606-1611.
Compeyrot-Lacassagne S, Tyrrell PN, Atenafu E, Doria
Gong G, Young N, Dempster H, Porepa M, Feldman
AS, Stephens D, Gilday D, Silverman ED: Prevalence
BM: The quality of my life (QOML) questionnaire:
Huber AM, Tomlinson GA, Koren G, Feldman BM:
and etiology of low bone mineral density in juvenile
The minimal clinically important difference (MCID)
Amitriptyline to relieve pain in juvenile idiopthic
systemic lupus erythematosus. Arthritis and
for pediatric rheumatology. Journal of Rheumatology
arthritis: a pilot study using Bayesian meta-analysis
Rheumatism 2007: 56(6): pp 1966-1973.
2007: 34(3): pp 581-587.
of multiple N-of-1 clinical trials. Journal of
Rheumatology 2007: 34(5): pp 1125-1132.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 159
Ota S, Cron RQ, Schanberg LE, O’Neil K, Mellins ED,
Jacob CO, Reiff A, Armstrong DL, Myones BL,
Compeyrot-Lacassagne S, Rosenberg AM, Babyn P,
Silverman ED, Klein-Gitelman M, McCurdy D, Wagner-
Laxer RM: Pamidronate in the treatment of chronic
Fuhlbrigge RC, Feldman BM: Research priorities in
Weiner L, Nocton JJ, Solomon A, Zidovetzki R:
non-infectious inflammatory lesions of the mandible
pediatric rheumatology: the Childhood Arthritis and
Identification of novel susceptibility genes in childhood-
in children. Journal of Rheumatology 2007: 34(7):
Rheumatology Research Alliance (CARRA) consensus.
onset systemic lupus erythematosus using a uniquely
pp 1585-1589.
Pediatric Rheumatology 2008: 6(1): p 5.
designed candidate gene pathway platform. Arthritis
Manlhiot C, Liang C, Tran D, Bitrum A, Tyrrell PN,
Ruperto N, Lovell DJ, Cuttica R, Wilkinson N, Woo P,
Feldman BM: Assessment of an infectious disease
Espada G, Wouters C, Silverman ED, Balogh Z,
Johnson S, Feldman BM, Hawker G: Classification
history preceeding juvenile dermatomyositis symptom
Henrickson M, Apaz MT, Baildam E, Fasth A, Gerloni V,
criteria for systemic scolerosis subsets. Journal
onset. Rheumatology 2008: 47(4): pp 526-529.
and Rheumatism 2007: 56(12): pp 4164-4173.
Lahdenne P, Prieur AM, Ravelli A, Saurenmann RK,
Gamir ML, Wulffraat N, Marodi L, Petty RE, Joos R,
of Rheumatology 2007: 34: pp 1855-1863.
Manlhiot C, Tyrrell P, Liang L, Atkinson A, Lau W,
Zulian F, McCurdy D, Myones BL, Nagy K, Reuman P,
Johnson SR, Goek O-N, Singh-Grewal D, Vlad SC,
Feldman BM: Safety of intravenous immunoglobulin
Szer I, Travers S, Beutler A, Keenan G, Clark J,
Feldman BM, Felson DT: Classification criteria in
in the treatment of juvenile dermatomyositis: adverse
Visvanathan S, Fasanmade A, Raychaudhuri A,
rheumatic diseases: a review of methodologic
reactions are associated with immunoglobulin A
Mendelsohn A, Martini A, Giannini EH, for the PRINTO
properties. Arthritis and Rheumatism 2007: 57 7):
content. Pediatrics 2008: 121(3): pp e626-30.
and PRCSG: A randomized, placebo-controlled trial of
Nicholson A, Berger K, Bohn R, Carcao M, Fischer K,
polyarticular course juvenile rheumatoid arthritis.
Lau A, Duong TT, Ito S, Yeung RSM: Matrix
Gringeri A, Hoots K, Mantovani L, Schramm W, Van
Arthritis and Rheumatism 2007: 56(9): pp 3096-3106.
Metalloproteinase-9 activity leads to elastin
Hout BA, Willan AR, Feldman BM: Recommendations
breakdown in an animal model of Kawasaki disease.
for reporting economic evaluations of haemophilia
Saurenmann R, Rose JB, Tyrrell PN, Feldman B, Laxer
prophylaxis: a normal group’s consensus statement
RM, Schneider R, Silverman ED: Epidemiology of
infliximab plus methotrexate for the treatment of
pp 1119-1133.
Arthritis and Rheumatism 2008: 58: 3: 854-63.
on behalf of the Economics Expert Working Group
juvenile idiopathic arthritis in a multi-ethnic cohort:
Lau A, Rosenberg H, Duong TT, McCrindle BW, Yeung
of the International Prophylaxis Study Group.
ethnicity as a risk factor. Arthritis and Rheumatism
RSM: Elastolytic matrix metalloproteinases and
Haemophilia 2007: 14: pp 127-132.
2007: 56(6): pp 1974-1984.
coronary outcome in children with Kawasaki disease.
Pediatric Research 2007: 61(6): pp 710-715.
160 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Singh-Grewal D, Schneiderman-Walker J, Wright V,
Sung L, Tomlinson GA, Greenberg ML, Koren G, Judd P,
BOOKS AND BOOK CHAPTERS
Bar-Or O, Beyene J, Selvadurai H, Cameron B, Laxer
Ota S, Feldman BM: Serial controlled N-of-1 trials of
Benseler SM: Kawasaki disease. In: Handbook of
RM, Schneider R, Silverman ED, Spiegel L, Tse S,
topical vitamin E as prophylaxis for chemotherapy-
Pediatric Emergency Medicine (Lalani A, Schneeweiss
LeBlanc C, Wong J, Stephens S, Feldman BM: Physical
induced oral mucositis in paediatric patients. European
S, eds.). Jones and Bartlett, Sudbury, MA, 2007.
exercise and activity in kids (PEAK): a randomized
Journal of Cancer 2007: 43(8): pp 1269-1275.
controlled single blinded trial of the effects of vigorous
Benseler SM: Koerperlische untersuchung. In:
exercise training on physical function in children with
Sung L, Tomlinson GA, Greenberg ML, Koren G, Judd P,
Paediatrische Rheumatologie (Wagner N, Dannecker
arthritis. Arthritis and Rheumatism 2007: 57(7):
Ota S, Feldman BM: Validation of the oral mucositis
GE Hrsg, eds.). Springer Medizin Verlag, Auflage, 2007.
pp 1202-1210.
assessment scale in pediatric cancer. Pediatric Blood
and Cancer 2007: 49(2): pp 149-153.
Benseler SM: Rheumatologic emergencies. In:
Tyrrell P, Beyene J, Benseler S, Sarkissian T, Silverman
Schneeweiss S, eds.). Jones and Bartlett, 2007.
Stephens S, Singh-Grewal D, Bar-Or O, Beyene J,
Cameron B, LeBlanc C, Schneider R, Schneiderman-
Handbook of Pediatric Emergency Medicine (Lalani A,
Walker J, Selvadurai H, Silverman E, Spiegel L, Tse S,
ED: Predictors of lipid abnormalities in children with
Wright V, Feldman BM: The reliability of exercise
new onset systemic lupus erythmatosus. Journal
Benseler SM: Seltene formen der vaskulitis. In:
testing and functional activity questionnaires in
of Rheumatology 2007: 34(10): pp 2112-2118.
Paediatrische Rheumatologie (Wagner N, Dannecker
children with juvenile arthritis. Arthritis and
Rheumatism 2007: 57(8): pp 1446-1452.
GE Hrsg, eds.). Springer Medizin Verlag, Auflage, 2007.
Uziel Y, Feldman BM, Krafchik BR, Laxer RM, Yeung
RSM: Increased serum levels of TGF>1 in children
Benseler SM, Kuemmerle-Deschner J: Tagayashu
Stinson J, Toomey P, Stevens B, Kagan S, Duffy C,
with localized scleroderma. Pediatric Rheumatology
arteritis. In: Paediatrische Rheumatologie ((Wagner N,
Huber A, Malleson P, McGrath P, Yeung RSM, Feldman,
2007: 5: p 22.
Dannecker GE Hrsg, eds.). Springer Medizin Verlag,
B: Asking the experts: exploring the self-management
Auflage, 2007.
needs of adolescents with arthritis. Arthritis Care
Yeung RSM: Lessons learned from an animal model
and Research 2008: 59: pp 65-72.
of Kawasaki disease. Clinical and Experimental
Feldman BM, Ravelli A: Maintaining flexibility: joints
Rheumatology 2007: 25: (1 Suppl 44): pp S69-S71.
and other considerations. In: Myositis & You: A Guide
Stringer E, Yeung RSM: Pathogenesis of Kawasaki
to Juvenile Dermatomyositis for Patients, Families and
disease: rhe central role of TNFО». Future
Yeung RSM: Clinical phenotype and coronary outcome
Health-care Providers (Rider L, Pachman L, Miller F,
Rheumatology 2008: 3: pp 69-77.
in Kawasaki disease. The Lancet 2007: 369: pp 85-88.
Bollar H, eds.). The Myositis Association, Washington,
DC, 2007.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 161
Laxer RM: Rheumatic Disease Clinic of North America,
Determinants of risks and outcomes in inflammatory
Feasibility and impact of qigong as compared to
Volume 33, Issue 3, Pediatric Rheumatology. Elsevier
arthritis. Siminovitch K, Yeung RSM, Bernatsky S,
aerobic exercise in the treatment of childhood chronic
Saunders Co., Philadelphia, 2007.
Bombardier C, Boillais L, MacPherson A, Oen K.
musculoskeletal pain: a pilot randomized controlled
Canadian Institutes of Health Research
trial. Tse SML, Feldman BM, Fairbairn J, O’Brien C,
Schneider R, Laxer RM: Systemic juvenile idiopathic
($2,000,000 2007-2012)
Bar-Or O, Schneiderman-Walker J, Singh-Grewal D,
Stephens S, Stinson J, Tyrell P, Whitney K, Wright V,
arthritis. In: Handbook of Systemic Autoimmune
Diseases (Cimaz R, Lehman T, eds.). Elsevier,
Development and usability and feasibility testing of a
Cameron B, Lefebvre A, Laxer R, Schneider R,
Oxford, UK, 2008.
web-based self-management program for adolescents
Silverman ED, Spiegel L, Wu H, Bustamante K.
with arthritis. McGrath PJ, Stinson J, Hodnett E,
SickKids Foundation Complementary and Alternative
Woo P, Laxer RM, Sherry DD. Pediatric Rheumatology
Feldman B, Duffy C, Huber A, Tucker L, Hetherington
Health Care and Paediatrics Research Grant
in Clinical Practice. Springer-Verlag, London, 2007.
R, Yeung R. Canadian Arthritis Network ($445,500
($128,223 2005-2007)
2007-2009)
FUNDING
Feasibility of an interactive web-based rheumatology
Biologically-based outcome predictors in juvenile
Development and usability and feasibility testing of a
teaching module for paediatric residents. Tse SM,
idiopathic arthritis. Rosenberg A, Baxter-Jones AD,
web-based self-management program for adolecents
co-investigators: Feldman BM, Schneider R, Hyman A,
Gordon J, Muhajarine N, Oen K, Pahwa P, Scherer S,
with arthritis. Feldman B. Canadian Institutes of
research team: Stringer E, Bassilious E, Batthish M,
Turvey S, von Baever C, Whiting SJ, Yeung RSM,
Health Research ($69,350 2007-2009)
Bendiak G, Gupta S, Bradley N, Cameron T, Tait G,
Shouldice M. Educational Dean’s Funds matched with
Bernatsky S, Duffy C, Silverman ED. Canadian
Institutes of Health Research/Canadian Arthritis
Development of a feasible tool to measure oral
Network ($1,500,000 2006-2011)
mucositis in children with cancer. Sung L, Judd P,
Department of Paediatrics Funds ($18,300 2007-2008)
Tomlinson D, Doyle J, Hendershot E, Maloney AM,
Inflammation and atherosclerosis in paediatric
Childhood Arthritis and Rheumatology Research
Feldman B. Pediatric Oncology Group of Ontario
rheumatic diesase. Bradley T, Beyene J, Schneider R,
Alliance. Sandborg C, Brewer E, Feldman B, Hirsch R,
($13,334 2007-2008)
Feldman B, Silverman ED. Heart and Stroke
Ilowite N, Jung L, Lovel D, Malleson P, Mellins E,
Foundation of Ontario ($125,488 2007-2009)
O’Neil K, Schanberg L, Wallace C. Arthritis
Foundation ($525,000 2004-2007)
International study: the efficacy of monoclonal
anti-TNF antibody in JRA. Extension phase. Silverman
ED (Site PI). Centocor Corporation ($110,000
2004-2010)
162 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
The role of chronic inflammation and systemic
Kawasaki disease: on our way to unravelling the
Pilot study of once-a-day prophylaxis for youth and
pathogenesis. Yeung RSM. Canadian Institutes
young adults with severe haemophila. Feldman BM,
lupus erythematosus-related factors in the
of Health Research ($318,873 2005-2008)
Rivard G, Carcao M, St-Louis J, Teitel J, Pulleneyegum E,
development of premature atherosclerosis in
Blanchette V. Bayer Partnership Fund ($250,000
paediatric SLE. Silverman ED, Bargman J,
New onset juvenile idiopathic arthritis: a Canadian
2007-2008)
Bradley T, Beyene J. The Heart and Stroke
Foundation of Canada ($275,000 2006-2009)
multicentre collaborative outcome study. Yeung RSM,
Duffy C, Oen K, Tucker L, Feldman B, Feldman D,
Research to improve outcomes for inflammatory
Young N, Spiegel L. Canadian Institutes of Health
arthritis. Inman R, Gladman D, Maksymowych W,
Towards a better understanding of Kawasaki disease.
Research ($998,000 2004-2009)
Rahman P (co-principal investigators), Davis A, Tsui F,
Yeung RSM. The Heart and Stroke Foundation of
Greenwood C, Badley E, Scherer S, Reeve J, Cook R
Canada ($160,565 2006-2008)
Novel biomarkers in inflammatory arthrits. Siminovitch K,
(project co-investigators), Boonen A, Choquette D,
Bernatsky S, Bombardier C, Boillais L, Yeung RS.
Colbert R, Frank J, Ghahary A, Gignac M, Husted J,
Canadian Arthritis Network ($150,000 2007-2009)
Keen K, Lambert R, Laxer R, Marra C, Mosher D,
heart block. Hamilton RH, Gross G, Silverman ED.
Mulholland K, Nair B, Poole R, Richards C, Salanen D,
Canadian Institutes of Health Research ($197,000
Pain in child health (PICH): an innovative,
Shojania K, Thomson G, Tse S. The Arthritis Society,
2006-2009)
transdisciplinary, cross-Canada, research training
National Research Initiative ($2,500,000 2005-2010)
Towards understanding the mechanism of congenital
Validation of accelerometry as a measure of physical
consortium. McGrath P, Craig K, von Baeyer C,
Stevens B, Johnston C, Finley A (co-principal
Rituximab therapy in refractory adult and juvenile IIM.
activity and inactivity in children with chronic disease.
investigators), Schellinck H, Unruh A, Kenny N,
Oddis CV, Reed AM, Pestronk A, Rider L, Miller F,
Feldman B, Stephens S, Takken T, Wright V, Tramblay
Camfield C, Harmon K, Frager G, Rathwell T, Howlett A,
Eisenberg R, Feldman BM, Ytterberg S, Levine T.
M, Beyenne J, Biggar W, Esliger D, Longmuir P,
Otley T, Connolly J, Feldman BM, Langer J, Taddio A,
National Institutes of Health ($7,732,309 2004-2009)
McCrindle B, Schneiderman-Walker J, Van Der Net J.
Hetherington R, Grunau R, Oberlander T, Chambers C,
Superantigens in autoimmunity. Yeung RSM. Canadian
2007-2008)
Dube L, Ohlsson A, Murray M, Barr R, Koren G
Institutes of Health Research ($172,553 2006-2008)
Canadian Institutes of Health Research ($64,985
Baruchel S, Brown S, Gibbins S, Salter M,
(co-investigators). Canadian Institutes of Health
Training Grant ($300,000 2002-2008)
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 163
Dr. Golda Milo-Manson
VICE PRESIDENT,
MEDICINE & ACADEMIC
AFFAIRS
Dr. Golda Milo-Manson
PHYSICIAN DIRECTORS
Dr. Peter Rumney,
Rehabilitation &
Complex Continuing Care
Dr. Darcy Fehlings,
Child Development Program
Dr. Rob Carmichael,
Chief of Dental Services
STAFF PHYSICIANS
Dr. Doug Biggar
Dr. Elizabeth Jimenez
Dr. Tamarah Kagan-Kushnir
Dr. Anne Kawamura
Dr. Jeffrey Kobayashi
164 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Dr.
Dr.
Dr.
Dr.
Dr.
Laura McAdam
Gilbert Miller
Angela Orsino
Jonathan Tolkin
Wendy Roberts
Bloorview Kids Rehab
OVERVIEW
MEDICAL EDUCATION
Developmental Paediatric Residency Program Director
As a provincial facility, we see almost 7,000 children
Year 2007
Dr. Golda Milo-Manson
and youth on an outpatient basis and we have over
Paediatric RII...................................... 380 days
650 patient admissions each year.
Neurology........................................... 80 days
Resident Coordinator
Psychiatry .......................................... 30 days
Dr. Anne Kawamura
Bloorview Kids Rehab offers both inpatient and
PM&R ................................................ 60 days
outpatient developmental and rehabilitation services
Medical students................................ 300 days
Academic Accomplishments
to the children and families of greater Toronto and
Developmental paediatric
see Division of Developmental Paediatrics Report.
provides tertiary services in pediatric rehabilitation to
subspecialty residents ........................ 980 days
the Province of Ontario.
TOTAL ................................................ 1830 days
HIGHLIGHTS
• April 2008 Royal College accreditation – full approval
• Third Annual Roszel Developmental Paediatric
Resident Research Day, February 2008
Resident Prize Winner: Dr. Kassia Johnson
• Dr. Darcy Fehlings: Inaugural holder, Bloorview
Children’s Hospital Foundation’s Chair in
Developmental Paediatrics, 2007
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 165
Division of
Dr. David Grant
DIRECTOR
Dr. David Grant
TRANSPLANT PHYSICIANS
Dr. Upton Allen
Dr. Darius Bagli
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Mark Cattral
John Coles
Anne Dipchand
Walid Farhat
Annie Fecteau
Hartmut Grasemann
Dr. Paul Greig
Dr. Elizabeth Harvey
Dr. Diane Hebert
Dr. Nicola Jones
Dr. Paul Kantor
Dr. Shaf Keshavjee
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Valerie Langlois
Simon Ling
Seema Mital
Vicky Ng
Marc de Perrot
Andrew Pierre
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Lisa Robinson
Pipi Salle
Mindy Solomon
Glen Van Arsdell
Thomas Wadell
Paul Wales
ADMINISTRATOR
Wanda Schoonheyt
ADMINISTRATIVE SUPPORT
Christine Garner
Transplant Centre
OVERVIEW
Our clinical programs were busy during the past year.
SickKids has one of the largest paediatric solid
A total of 56 organs were transplanted in 52 children
including the North American Paediatric Renal
organ transplant programs in North America, with
and our sphere of clinical activity expanded with the
Transplant Co-operative Study Group, the Paediatric
We contribute to international research groups,
well over 1,000 children in receipt of a solid organ
integration of the Group for the Improvement of
Heart Transplant Study Group, NIH-funded fulminate
graft. We deliver cutting-edge, family-centred patient
Intestinal Function and Treatment (GIFT) into the
liver failure study group, and the Paediatric Liver
care with clinical volumes that are within the top
Transplant Centre. To meet growing clinical needs
Transplantation Registry. Local research projects with
five-10 per cent of transplant centres in North America.
and ensure that our patients receive care on the
extramural funding include: vaccination strategies;
Patient survival rates match or exceed the best
appropriate unit, the hospital created surge capacity
prevention of Epstein-Barr virus and Respiratory
programs worldwide. Our clinical programs are
on 6B in 2008 and expanded our interdisciplinary
Syncytial virus complications post-transplantation
enhanced by interdisciplinary educational programs;
team to improve access to rehabilitation services,
(Upton Allen); quality of life following heart and liver
fellowship training in transplantation; and basic,
psychology and transplant pharmacy expertise.
transplantation (Anne Dipchand, Stacey Pollack,Vicky
Ng); xenotransplantation (David Grant, Thomas
translational and clinical research.
We were also busy academically. Members of the
Wadell); adolescent issues of transition to adult care
Formerly known as the Paediatric Academic Multi-
Transplant Centre served as advocates for paediatric
(Miriam Kaufman); techniques to enhance
Organ Transplant Program (PAMOT), we successful
solid organ transplantation at the provincial, national
lung recovery for transplantation (Shaf Keshavjee and
transitioned to become the SickKids Transplant
and international levels as members of the Board of
colleagues); and leukocyte trafficking in allograft
Centre in February 2008. A search for a new executive
the International Paediatric Lung Transplant
rejection (Lisa Robinson). Our trainees continued to
team was completed in June 2008 with the
Committee (Mindy Solomon); International Paediatric
reflect the international appeal of our fellowship
appointment of David Grant as Director; Anne
Transplant Association (Anne Dipchand); Trillium Gift
program with Dr. Meeta Malik (Chief Fellow 2007-08)
Dipchand, Associate Clinical Director; Freda Miller,
of Life (Diane Hebert); and as president of the
becoming an international ambassador for SickKids
Associate Research Director; and Wanda Schoonheyt,
International Intestine Transplant Society (David
as she assumed her faculty position in the UK.
Director, Clinical Programs.
Grant). Our basic and clinical research activities
continued to focus on optimizing long-term transplant
In 2008-09, the new Transplant Centre will focus
outcomes in children.
on fundraising, improving our educational offering
building stronger links with families and referring
doctors and enhancing our research programs.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 167
2007-08 Housestaff
Paediatric Housestaff
CHIEF RESIDENTS - PGY4S
Dr. Nirit Bernhard
Dr. Sharon Naymark
ASSOCIATE CHIEF RESIDENTS
- PGY4S
Dr. Karoon Danayan
Dr. Elizabeth Gold
Dr. Krishanthi Gunawardena
Dr. Mary Kiaira
THIRD-YEAR RESIDENTS PGY3S
Dr. Dalia Al-Abdulrazzaq
Dr. Fatoumah Al-Abdulrazzaq
Dr. Amal Al-Maani
Dr. Sowmya Balasubramanian
Dr. Ereny Bassilious
Dr. Michelle Batthish
Dr. Glenda Bendiak
Dr. Nicholas Blanchette
Dr. Michelle Bridge
Dr. Karoon Danayan
Dr. Sumit Gupta
Dr. Joelene Huber
Dr. Sangeet Kathuria
Dr. Tarek Khalefih
Dr. Melanie Makhija
Dr. Shruti Mehrotra
Dr. Briseida Mema
Dr. Caroline McLaughlin
Dr. Michelle Porepa
Dr. Ewurabena Simpson
Dr. Andrea Wan
Dr. Kevin Weingarten
Dr. Eitan Weinberg
SECOND-YEAR RESIDENTS PGY2S
Dr. Dr. Fahed Aljaser
Dr. Ahmed Alterkait
Dr. Kesete Bezu
Dr. Joyce Ching)
Dr. Avram Denburg
Dr. Alisha Kassam
Dr. Rae Koffman
Dr. Dianne Lim
Dr. Nadia Luca
Dr. Arif Manji
Dr. Gagandeep Saund
Dr. Deena Savlov
Dr. Ksenia Slywynska
Dr. Gordon Soon
Dr. Christopher Sulowski
Dr. Mark Tessaro
Dr. Nisha Thampi
Dr. AlГЁne Toulany
FIRST-YEAR RESIDENTS PGY1S
Dr. Leila Fazeli Chaghoshi
Dr. Amy French
Dr. Silvio Gonzalez
Dr. Andrea Hoffman
Dr. Emilie Jean-St-Michel
Dr. Julie Johnstone
Dr. Dina Kulik
Dr. Ana Marissa LagmanBartolome
Dr. Paola Luca
Dr. Mary Kate Mennie
Dr. Niraj Mistry
Dr. Reem Mohammed
Dr. Nikhil Pai
Dr. Anastasios (Taso)
Papadopoulos
Dr. Cynthia Popalis
Dr. Alisha Rachlis
Dr. Audrey Segal
Dr. Maher Shalabi
Dr. Shawna Silver
Dr. Jennifer Smith
Dr. Anita Villani
Dr. Cyrus Boelman (PGY1 neuro)
Dr. John Brandsma (PGY1 neuro)
PRACTICE READY
ASSESSMENT (PRA)
Dr. Mariana Boragina
Paediatric Grand Rounds
2007
August 22 – Michaela Cada, Tony Truong, Division
October 3 – Dr. Michael Geraghty, Head, Department
July 4 – Zia Bismilla, Adam Rapoport, Barry Seltz,
of Haematology/Oncology: Childhood cancer survivors
of Genetics and Metabolism, Children’s Hospital of
Division of Paediatric Medicine: Academic general
and late effects: paying the price for cure
Eastern Ontario: Expanded newborn screening in Ontario
paediatric research: changing the way we practice
July 11 – Fotini Kavadas, Elana Lavine, Division
August 29 – April Kam, Chris Ricks, Division
October 10 – Dr. David Goodman, Centre for Health-
of Paediatric Emergency Medicine: Foul play
care Research and Reform, the Dartmouth Institute for
September 5 – Dr. Fraser Mustard, Head, Founder’s
Harry Bain PSI Lecture: Are more paediatricians linked
Network, Companion of the Order of Canada, Laureate
to better health outcomes for children?”
of Immunology/Allergy: Changes in ancient places:
new directions in immunodeficiency
Health Policy and Clinical Practice, New Hampshire:
July 18 – Rachel Spitzer, Divison of Endocrinology -
of the Canadian Medical Hall of Fame: Robert Haslam
Adolescent Gynaecology: Meeting contraceptive challenges:
Lecture: early child development and trajectories
October 17 – Dr. Fiona Campbell, Anaesthesia,
contraception for the medically complex adolescent
in physical and mental health
SickKids: Pain matters
July 25 – Linda Hiraki, Heinrike Schmeling,
September 12 – Dr. Phil Sherman, SickKids,
October 24 – Dr. Joseph Flynn, Nephrology,
Sathish Kumar, Division of Rheumatology:
Division of Gastroenterology, Hepatology and
Children’s Hospital of Montefiore: Ambulatory
Childhood chronic arthritis: can we do better?
Nutrition: Probiotics and gastrointestinal health:
blood pressure monitoring in children and
ready for prime time?
adolescents: where are we in 2007?
August 1 – Reshma Amin, Division of Respiratory
Medicine: Cystic Fibrosis: from salt licks to heel pricks
September 19 – Dr. Friedhelm Hildebrandt, Professor
October 31 – Dr. Russell Ware, Chair, Department
of Pediatrics and Human Genetics, Frederick Huetwell
of Haematology, St. Jude Children’s Research Hospital,
Professor for the Cure and Prevention of Birth Defects
Memphis Bernard Laski Lecture: The rational use of
Division of Gastroenterology, Hepatology and Nutrition:
University of Michigan, Ann Arbor: Genetics of inherited
hydroxyurea in sickle cell disease
Is my baby yellow or is it the new compact fluorescent
renal disease
August 8 – Catharine Walsh and Eric Benchimol,
November 7 – Dr. Norman Fost, Director, Program
light bulb? An approach to the jaundiced infant
September 26 – Michael Weinstein, David Chiasson,
in Bioethics, Vice-Chair, Department of Medical
August 15 – Jonathon Costello, Hadi Mohseni-Bod
Greg Wilson, SickKids: Clinical Pathology Conference:
History and Bioethics, University of Wisconsin Hospital:
(Aphrothite Kotsakis), Critical Care Response Team:
case review: a case of a child with fever
Bioethics Lecture: Parental requests for �futile’ treatment
Critical Care Response Team (CCRT) at The Hospital
for Sick Children: evidence and practice
170 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
November 14 – Dr. Richard Aplenc, Pediatric
2008
February 20 – Dr. Noni MacDonald, former Dean of
Oncology/Stem Cell Transplant Program, Children’s
January 9 – Dr. Robert Hamilton, Division of
Medicine, Dalhousie University, Halifax, Nova Scotia:
Hospital of Philadelphia: Daniel Burton Lecture:
Cardiology, SickKids: Clinical and research cardiac
Sexually-transmitted infections and youth: reality bites
Studies of genetic variation and paediatric leukaemia:
genetics in high-risk hereditary heart conditions
February 27 – Dr. Amitai Ziv, Director, Israel Center
if you mix ice cream with cow manure, it won’t hurt the
for Medical Simulation, Deputy Director, Chaim Sheba
cow manure
January 16 – Dr. David Fisman, Child Health Evaluative
Sciences, SickKids Making best bets: how modelling
Medical Center, Israel: Medical Education Day: Medical
November 21 – Dr. Sylvain Chemtob, Pediatrics,
can inform vaccine policy
simulation changing the face of medical education
HГґpital Ste. Justine, UniversitГ© de MontrГ©al: Barry
Smith Lecture: Insights into retinopathy of prematurity:
injury invites repair
in the 21st century
January 23 – Dr. Ben Alman, Head of Orthopaedic
Surgery, SickKids: From fibromatosis to fractures:
March 5 – Dr. Walter Kahr, Division of Haematology/
new therapies based on modulating beta-catenin
Oncology, SickKids: New insights in cell biology
November 28 – Dr. Sheldon Kaplan, Chief of Infectious
from studies of inherited platelet disorders
Disease, Texas Children’s Hospital: Community-
January 30 – Dr. Charles Scriver, Alva Professor
acquired methicillin resistant Staphylococcus
Emeritus of Human Genetics, McGill University,
aureus infections - they are everywhere
December 5 – Dr. Bruce Gelb, Arthur J and Nellie Z
March 19 – Dr. Robert Sundel, Rheumatology,
Montreal Children’s Hospital Research Institute:
Harvard University, Boston: Kawasaki disease
Jacob’s Ladder Lecture: The journey but not the
at 40 years old
arrival yet. A model for �personalized medicine’?
Cohen Professor of Pediatrics and Genetics and
March 26 – Dr. Paul Kurtin, Vice-President and Chief
Genomic Sciences, Mount Sinai Hospital, New York:
February 6 – Dr. Jeffrey Whitsett, Chief of
Quality and Safety Officer, Center for Child Health
Noonan Syndrome and related disorders: RAS
Neonatology, Perinatal & Pulmonary Biology,
Outcomes, Children’s Hospital, San Diego: Improving
Cincinnati Children’s Hospital: Genetic basis
care for the children of Ontario
signalling – getting it just right
of normal adaptation to air breathing
December 12 – Dr. Carole Marcus, Pediatric
April 2 – Dr. Andrew Redington, Head, Division of
Pulmonary Medicine, Joseph Stokes Jr. Research
February 13 – Dr. Anne Matlow, Director, Infection
Institute, Children’s Hospital of Pennsylvania:
Prevention and Control Program and Medical
Cardiology, SickKids: Remote ischemic preconditioning:
harnessing an innate mechanism of cellular protection
Childhood obstructive sleep apnea – implications
Director, Patient Safety, SickKids Can we do
against ischemic injury in adults and children
for future health
more to help achieve closure through disclosure?
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 171
April 9 – Dr. Michael Cabana, Director, Division
April 30 – Paediatric Update, Dr. Harriet MacMillan,
May 21 – Dr. David Hackam, Roberta Simmons
of General Pediatrics,Professor of Pediatrics,
McMaster University (Host: Dr. Suzan Schneeweiss):
Associate Professor of Pediatric Surgery, Cell Biology
Epidemiology and Biostatistics, UCSF: Physician
Paediatric Update: An overview of family violence:
and Physiology, University of Pittsburgh School of
asthma care education: results of the PACE study
implications for child development and approaches
Medicine, Department of Pediatric General and
to prevention
Thoracic Surgery, Children’s Hospital of Pittsburgh
April 16 – Dr. Kevin Chan, Division of Paediatric
of UPMC A novel role for the innate immune system
Emergency Medicine: Global child health research,
May 7 – Dr. Vivien Burt, Professor of Psychiatry,
in the pathogenesis and treatment of neonatal
from Harvard to Toronto
David Geffen School of Medicine, UCLA: Motherisk
necrotizing enterocolitis
Lecture: Mood disorders in women: focus on
reproductive transitions
May 28 – ANNUAL RESEARCH DAY
building humanitarian projects
May 14 – Dr. Lisa Shaffer, CEO and Technical Director,
June 4 – Professor Linda DeMeirleir, Head of Pediatric
Signature Genomic Laboratories, Spokane, WA: The
Neurology, University of Belgium, Brussels Barsky
Dr. Robert Hilliard, Division of Paediatric Medicine:
use of array CGH in dDiagnosis and syndrome discovery
Lecture: The clinical spectrum of mitochondrial
Dr. Dennis Scolnik, Division of Paediatric
Emergency Medicine: Starting small and
diseases in young children and approach to diagnosis
The changing scene of medical education in Africa
Global Child Health Lecture: What SickKids is,
May 21 – Dr. Suzanne Kamel-Reid, Senior Scientist,
could and should be doing?
Division of Applied Molecular Oncology, Ontario
June 11 – Dr. Anne Matlow, Director, Infection
Cancer Institute (OCI) Princess Margaret Hospital,
Prevention and Control Program and Medical Director,
April 23 – Dr. Jay Rosenfield, Vice-Dean,
University Health Network: Andrew Sass-Kortsak
Patient Safety, SickKids: Patient Safety Symposium
Undergraduate Medical Education, University
Memorial Lecture: Insights into the biology of acute
of Toronto: The future of (undergraduate) medical
promyelocytic leukaemia: the role of variant fusion proteins
education in Canada
172 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
June 18 – ANNUAL AWARDS DAY
Promotions/Recognition
PROMOTED TO PROFESSOR OF PAEDIATRICS
Dr. Debra Katzman
THOSE WHO REACHED
NORMAL RETIREMENT AGE
The following reached normal
PROMOTED TO ASSOCIATE PROFESSOR
OF PAEDIATRICS
retirement age in June of 2008:
Dr. Manuel Carcao
Dr. Milton Gold
Dr. Jill Hamilton
Dr. Andrew Shennan
Dr. Hartley Garfield
Dr. Meredith Irwin
Dr. Kyong-Jin Lee
25 YEARS OF SERVICE AWARDS
Dr. Golda Milo-Manson
The following were honoured for their
Dr. Hiroshi Otsubo
25 years of service to The Hospital
Dr. Jose Luis Perez Velasquez
for Sick Children in June of 2008:
Dr. Jonathan Pirie
Dr. Carlos Contreras
Dr. Elena Pope
Dr. Hyder Fazal
Dr. Lisa Robinson
Dr. Dennis Gurwitz
Dr. Shelly Weiss
Dr. Peggy Kirkpatrick
Dr. Ken Schelberg
Awards
TEACHING/EDUCATION AWARDS
Dr. Brian Chisamore – Postgraduate Community
Dr. Leah Harrington – RHA Haslam Pre-Clerkship
Teaching Award in recognition of excellence in the
CLINICAL AWARDS
Dr. Victor Blanchette – Richard Rowe Award for
Teaching Award to the faculty member who has
teaching of paediatric residents within community-
Clinical Excellence in Paediatric Medical Care to the
demonstrated excellence in pre-clerkshop teaching.
based hospitals and offices.
physician in the Department of Paediatrics who has
demonstrated excellence in the delivery of clinical care
Dr. Raymond Shu – The Lionel Weinstein Clerkship
Dr. Shazhan Amed – PERLS (Paediatric Educational
in the broadest sense over a significant period of time.
Teaching Award to the faculty member who has
Resident Lecture Series) Award to the faculty member
demonstrated excellence in clerkship teaching.
who has demonstrated commitment to excellence in
Dr. Angelo Mikrogianakis – Junior Faculty Award for
teaching at the paediatric academic sessions.
Clinical Excellence in Paediatric Medical Care to a
Teaching Award in recognition of excellence in
Dr. Earl Silverman – Subspecialty Teaching Award
appointment to an academic health sciences centre,
the teaching of medical students within community-
to the faculty member who has demonstrated
who has demonstrated excellence in the delivery of
commitment to excellence in teaching the
clinical care.
Dr. Eddy Lau – The Undergraduate Community
based hospitals and offices.
physican within the first five to 10 years of
subspecialty residents and clinical fellows.
RESEARCH AWARDS
Dr. Eyal Cohen – Harry Bain Award to a full-time
member of the Department of Paediatrics who
Dr. Jonathan Pirie – Continuing Medical Education
Dr. Lillian Sung – Junior Physician Researcher Award
has demonstrated excellence in teaching as
Award to the faculty member in recognition of
to recognize outstanding achievements and progress
nominated by core paediatric residents.
excellence in course co-ordination in an event
within the first six years after initial appointment as a
sponsored by the Department of Paediatrics/
faculty member at an academic health sciences centre.
Dr. Sheila Jacobson – Marvin Gerstein Award to a
University of Toronto and/or long-term contribution to
part-time member of the Department of Paediatrics
Continuing Education in the Department of Paediatrics.
PAEDIATRIC ADMINISTRATIVE AWARD
who has demonstrated excellence in teaching as
Annabel Sousa – In recognition of an administrative
nominated by core paediatric residents.
support staff member in the Department of Paediatrics
who has demonstrated outstanding performance and
excellence in all aspects of their role. This individual
possesses outstanding communication and
interpersonal skills and is motivated to perform
above and beyond their daily responsibilities.
This award was first awarded in 2007.
174 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Resident and Fellow Awards and Achievements
TEACHING/EDUCATION AWARDS
RESEARCH AWARDS
Dr. Briseida Mema, PGY3, Dr. Ewurabena Simpson,
Core Paediatrics
PGY3, Dr. Sharon Naymark, PGY4 – Christopher Ondaatje
1. Sumit Gupta
Award to a senior resident for excellence in clinical
2. Anita Villani
teaching as nominated by core paediatric residents.
SENIOR TRAINEE – CLINICAL SCIENCE
CANMEDS AWARD – SUBSPECIALTY FELLOW
Dr. Leonard Barry Selz
1. Ghassan Abu Kuwaik
2. Haydi Al Wassia
Tie 3. Amy Lee Chong
CLINICAL AWARDS
Tie 3. Daria Grafodatskaya
Dr. Michelle Batthish – The Saunders Prize
to a senior resident who has demonstrated
SENIOR TRAINEE – BASIC SCIENCE
excellence in clinical paediatrics.
Tie 1. Aleixo Muise
Tie 1. Adam Shlien
176 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 177
Annual Resident and Fellow Research Day (May 28, 2008)
ORAL PRESENTATIONS
Osman M, Respiratory Medicine
Al-Jasmi F, Clinical and Metabolic Genetics
Al-Harthy N, Paediatric Emergency Medicine
Asthma morbidity: is it peanuts? Osman M,
Computer-assisted teaching of mucopolysaccridosis
The crying infant: which tests to choose?
Foty R, To T, Atkinson A, Stieb D, Dell S
by patient management problems Al-Jasmi F,
Al-Harthy N, Freedman SB, Thull-Freedman J
Moldovan L, Clarke JTR
Tole S, Nephrology
Alwassia H, Neonatology
SLIT-2 inhibits neutrophil chemotaxis. Tole S,
Neonatal outcomes in multiple gestations:
Huang YW, Rui M, Yan M, Liu GY, Robinson LA
does mode of conception have an impact?
Alwassia H, Shah K, Shah P, Shah V
Aljunaibi A, Endocrinology
Factors affecting postsurgical blood sugar levels in
children and youth with Type 1 diabetes mellitus
Wine E, Gastroenterology, Hepatology and Nutrition
(T1D) undergoing anaesthesia/surgery. Aljunaibi A,
Osteopontin-null mice are protected from citrobacter
Stephens D, Daneman D
Appendino J, Neurology
rodentium-induced colonic hyperplasia due to a reduction
The impact of amplitude integrated
in attaching-effacing lesions. Wine E, Shen-Tu G, Ngan
AlKhater R, Neurology
electroencephalography on neonatal
B-Y, Licht C, Sodek J, Zohar R, Sherman PM
Toward the identification of paediatric movement
intensive care unit practice. Appendino JP,
McNamara P, Keyzers M, Hahn C
disorders genes. A family with a novel neurological
POSTER PRESENTATIONS
disorder. AlKhater RA, Rilstone J, Minassian BA
Abosoudah I, Haematology/Oncology
Bismilla Z, Paediatric Medicine
WT1 expression and hemihypertrophy in congenital
Al-Murshedi F, Clinical and Metabolic Genetics
Evaluation of neonatal endotracheal intubation
mesoblastic nephroma. Abosoudah I, Ngan B-Y,
Elevated propionylcarnitine on newborn screening
skill in a tertiary care NICU. Z Bismilla, E Finan,
Grant R, Weitzman S
and vitamin B12 levels. Al-Murshedi F, Al-Jasmi F,
Jefferies A, Whyte H, LeBlanc V
Crushell E, Feigenbaum A
Abu Kuwaik G, Developmental Paediatrics
Gupta S, Core Paediatrics
Immunization uptake of siblings of children with
Al-Qadhi S, Paediatric Emergency Medicine
Incidence and predictors of treatment related
Autism. Abu Kuwaik G, Green PE, Roberts W,
A retrospective chart review of nail bed lacerations in
mortality in paediatric acute leukaemia in El Salvador.
Zwaigenbaum L, Bryson S, Brian J, Szatmari P, Smith I
children presenting to ER. Al-Qadhi S, Ratnapalan S
Gupta S, Bonilla M, Fuentes SL, Howard SC, Caniza M,
Barr R, Greenberg ML, Ribeiro R, Sung L
Akiyama T, Neurology
Al-Rawas A, Haematology/Oncology
Movie of ictal high-frequency oscillations and intracranial
Treatment of primary brain sarcoma with Ifosphamide,
video EEG: marching high-frequency power correlating
Carboplatin, Etoposide (ICE) and focal radiation.
with symptoms in Jacksonian seizures. Akiyama T
Al-Rawas A, Bouffet E, Laperriere N, Bartels U
178 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Al-Saleh S, Respiratory Medicine
Barnett C, Clinical and Metabolic Genetics
Brandsema J, Neurology
Induced sputum compared with expectorated
Loeys-Dietz syndrome: in-vitro restoration of fibrillin
The incidence of asymptomatic cerebral arteriopathies
sputum to identify respiratory pathogens in children
and elastin production after treatment with losartan
in neurofibromatosis type 1: the need for MRI
with cystic fibrosis. Al-Saleh S, Grasemann H,
and dexamethasone. Barnett C, Hinek A, Bradley TJ,
screening. Brandsema J, Rea D, Parkin P, Armstrong D,
Dell S, Yau Y, Waters V, Martin S, Ratjen F
Chitayat D
Askalan R
Al-Shanteer S, Neonatology
Barton-Forbes M, Infectious Diseases
Bronte-Tinkew D, Gastroenterology,
Response times and severity of illness during the
Post-transplantation Lymphoproliferative Disorder
Hepatology and Nutrition
transport of neonates: is there a relationship?
(PTLD) in pediatric solid organ transplant recipients:
Helicobacter pylori caga activates the signal
Al-Shanteer S, Lee K-S, Tomlinson C, Whyte H
A review of Hospital for Sick Children (SickKids)
transducer and activator of transcription 3 (STAT3)
PTLD Registry: 2000-2007. Barton-Forbes M,
pathway in vitro and in vivo. Bronte-Tinkew DM,
Amin R, Respiratory Medicine
Melbourne T, Heurter H, Dipchand A, Hebert D, Ng V,
Terebiznik M, Franco A, Ahn D, Mimuro H,
Chronic infection with aspergillus fumigatus
Solomon M, Fecteau A, Grant D, Ngan B, Allen UD
Sasakawa C, Ropeleski MJ, Peek Jr. RM, Jones NL
exacerbations in cystic fibrosis patients.
Benchimol E, Gastroenterology, Hepatology and Nutrition
Cain J, Nephrology
Amin R, Corey M, Tullis E, Ratjen F
Toxic megacolon in children with inflammatory bowel
Lineage specific functions of sonic hedgehog
disease: Clinical and radiographic characteristics.
signalling during murine kidney development.
Baaboud A, Emergency Medicine
Benchimol EI, Turner D, Mann EH, Thomas KE,
Cain JE, Nieuwenhuis E, Hui C-C, Rosenblum RD
Timing of administration of antibiotic and
Gomes T, McLernon RA, Griffiths AM
is associated with higher rates of pulmonary
Chan D, Neurology
clinical outcome in febrile neutropenia with
oncology disease. Baaboud A, Ratnapalan S
Boelman C, Neurology
The relationship between rapid oscillatory activity
Cerebrovascular disease in meningitis: Safety and
in premature and normal term neonatal EEG and
Baker J, Haematology/Oncology
efficacy of anticoagulation. Boelman C, Askalan R
the effect of phenobarbitone. Chan D, Yamazaki M,
Prognostic factors in advanced-stage paediatric
Akiyama T, Chu B, Donner E, Otsubo H
anaplastic large cell lymphoma (ALCL): analysis of
Boskovic R, Clinical Pharmacology and Toxicology
patients from two consecutive Pediatric Oncology
Long-term outcomes of children prenatally exposed
Crushell E, Clinical and Metabolic Genetics
Group of Ontario (POGO) studies. Baker JM,
to valproic acid and carbamazepine: meta-analysis.
The Lebers hereditary optic neuropathy mutation
Weitzman S, Breakey VR, Smith JN, Zagorski BM,
Boskovic R, Banach R, Einarson T, Moretty M, Koren G
T14484C can cause Leigh-like disease. Crushell E,
Hutchison RE, Laver JH
Robinson B, Blaser S, Murray S, Ainsworth PJ,
Feigenbaum A.
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 179
Crystal M, Cardiology
Fujimoto A, Neurology
Go C, Neurology
Coronary stents in children: a bridge to surgery.
Total intravenous anaesthesia for MEG sediation,
Effects of valproic acid withdrawal on seizures by
Crystal MA, Hickey EJ, Lee K-J, Chaturvedi RR,
part II. Fujimoto A, Ochi A, Sugiyama I, Akiyama T,
analysis of scalp and intracranial video EEG. Go C et al
Benson LN
Otsubo H, Snead III OC
Di Giovanni V, Nephrology
Gana J, Gastroenterology, Hepatology and Nutrition
The BMP receptor, ALK3, controls murine
Non-invasive diagnosis of esophageal varices
patients with duplication 17p11.2 syndrome.
nephrogenesis. Di Giovanni V, Rosenblum N
in children. Gana JC, Roberts E, Ng VL, Ling SC
Goh E, Goobie S, Yoon G, Shago M, Sgro M,
Goh E, Goobie S, Clinical and Metabolic Genetics
Bilateral dysplastic kidneys as a feature in
Chitayat D, Mendoza-Londono R
Durbin A, Haematology/Oncology
Garcia-Bournissen F,
A JNK dependent switch determines the
Clinical Pharmacology and Toxicology
Gonska T, Gastroenterology, Hepatology and Nutrition
oncogenic or tumour suppressive activity of ILK
Comparison of cocaine levels in hair of children
Development of a novel outcome parameter for
in rhabdomyosarcoma. Durbin AD, Somers GR,
and their parents: a tool to estimate environmental
clinical trials in cystic fibrosis. Gonska T, Ip W,
Forrester M, Hannigan GE, Malkin D
exposure to drugs of abuse. Garcia-Bournissen F,
Bear C, Quinton P, Durie P
Nesterenko M, Koren G
Grafodatskaya D, Clinical and Metabolic Genetics
Elbers J, Neurology
Small-vessel CNS vasculitis in childhood: clinical
Gillis J, Clinical and Metabolic Genetics
Search for epigastric changes using agilent CpG-
and pathological correlation. Elbers J, Halliday W,
A novel karyotype involving a pericentric X
island microarrays in children with autism born after
Hawkins C, Benseler S
chromosome inversion and mosaicism for two
assisted conception. Grafodatskaya D, Lou Y, Zhao C,
cell lines with different 5p deletions, presenting
Scherer S, Weksberg R
Faghfoury H, Clinical and Metabolic Genetics
as neonatal hyperammonemia. Gillis J, George A,
Interstitial deletion of chromosome (10)
Shago M, Antinucci D, Feigenbaum A, Rohrbach M
Faghfoury H, Summers AM, Li C
Guttman O, Gastroenterology, Hepatology and Nutrition
Biliary atresia with associated structural
(q23.32q24.1) in a mother and her two offspring.
Glatstein M, Paediatric Emergency Medicine
malformations: the Canadian Multicentre Study from
Clinical and radiologic predictors of hyponatremia
1985-2002. Guttman OR, Schreiber RA, Barker CC,
Ferreira J, Choufani S, Clinical and Metabolic Genetics
in children hospitalized with pneumonia. Glatstein M,
Ng VL, Roberts EA, the Canadian Paediatric
DNA methylation profiling in placentas of intra-uterine
Parkin P, Freedman S, Miller E
Hepatology Research Group
growth restricted fetuses and normal controls
using agilent CPG island microarrays. Ferreira J,
Grafodatskaya D, Choufani S, Weksberg R
180 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Hamud O, Neonatology
Hutchinson C, Rheumatology
Kim J, Nephrology
Clinical presentation and management of
Open label study for treatment of angiography-
The role of suppressor of fused in cerebellar
supraventricular tachycardia (SVT) in neonates.
negative, biopsy-positive primary CNS vasculitis in
development. Kim J, Gill P, Zhang M, Hui CC,
Hamud O, Lee K-S
children. Hutchinson C, Elbers J, Halliday W, Branson H,
Rosenblum ND
Laughlin S, Armstrong D, Hawkins C, Benseler SM
Hawkes M, Infectious Diseases
Klieger-Grossmann C,
CD36 deficiency confers relative resistance
Hutter D, Cardiology
Clinical Pharmacology and Toxicolgy
to mycobacterial infection. Hawkes M, Li X,
The use of inhaled nitric oxide in the Critical Care Unit,
The safety of quinolones in the first trimester
Crockett M, Diassiti A, Liu J, Kain KC
The Hospital for Sick Children, Toronto: a retrospective
of pregnancy: a meta-analysis. Klieger-Grossmann C,
review 1994-2006. Hutter D, Sambamoorthi S, Humpl T
Boskovic R, Moretti M, Koren G
Jain S, Clinical and Metabolic Genetics
Koifman A, Clinical and Metabolic Genetics.
Hiraki L, Rheumatology
Predicting macrophage activation syndrome (MAS)
in paediatric systemic lupus erythematosus (pSLE)
Gender identity in males with 46XX congenital
Diaphragmatic hernia – limb abnormalities
patients at diagnosis. Hiraki LT, Tyrrell PN,
adrenal hyperplasia. Jain S, Zucker K, Wherrett D
syndrome (Froster syndrome). Koifman A,
Shannon P, Kingdom J, Chitayat D
Benseler SM, Abdelhaleem M, Silverman ED
Johnson K, Developmental Paediatrics
Huber J, Core Paediatrics
Books for siblings of children with autism: children’s
Koltin D, Endocrinology
An investigation of body composition, metabolic rate
assessments. Johnson K, McKeever P, Kawamura A
Medication induced diabetes during induction
and body mass in children and adults with Prader-Willi
therapy in paediatric acute lymphoblastic leukaemia.
syndrome enrolled in an obesity intervention program.
Jurencak R, Rheumatology
Huber J, Balko K, Berall G
Expression of interleukin-17 in synovial fluid and
peripheral blood in juvenile idiopathic arthritis.
Kumar S, Rheumatology
Hussey S, Gastroenterology, Hepatology and Nutrition
Jurencak R, Duong TT, Chung L, Feldman BM, Yeung RSM
B cell depletion for autoimmune thrombocytopenia
Prospective study of major upper gastrointestinal
hemorrhage in children. Hussey S, Kelleher K, Ling SC
Koltin D, Sung L, Naqvi A, Urbach SL
and autoimmune hemolytic anaemia in paediatric
Kavadas F, Immunology and Allergy
systemic lupus erythematosus. Kumar S,
High-dose methylprednisolone is effective in
Benseler S, Kirby-Allen M, Silverman E
the management of acute GvHD. Kovadas FD,
Somech R, Atkinson A, Grunebaum E, Roifman CM
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 181
Lara-Corrales I, Paediatric Medicine
Maegawa G, Clinical and Metabolic Genetics
Mittal A, Neonatology
The efficacy of trimethoprim in wound healing
Juvenile GM2 gangliosidosis: a model for investigation
PDA categorization predicts post-ligation need for
of patients with epidermolysis bullosa: a randomized,
of small molecule therapies for lysosomal storage
cardiotropes. Mittal A, Dos Santos S, Hellmann J,
Lee K-S, McNamara PJ
double blinded, placebo-controlled, cross-over pilot
diseases. Maegawa GHB, Banwell B, Tropak M,
study. Lara-Corrales I, Parkin P, Stephens D,
Buttner J, Rigat B, Hawkins C, Ackerley C,
Weinstein M, Sibbald G, Pope E
Hayes J, Tifft C, Tlopak M, Sorge G, Blaser S,
van Giersbergen P, Clarke JTR, Mahuran DJ
Lau M, Neonatology
The role of secondary septation during
lung development. Lau M, Tanswell AK
Lavine E, Immunology and Allergy
Lee Chong A, Haematology/Oncology
Maguire J, Paediatric Medicine
Is iron deficiency anaemia an additive risk factor
Muise A, Gastroenterology, Hepatology and Nutrition
for stroke in children who have major risk factors
Defects in E-cadherin are associated with its
for stroke? Magurie J, deVeber G, Parkin P
cytoplasmic accumulation and with NOD2
polymorphisms in Crohn’s disease patients.
Makhani N, Neurology
Muise AM, Walters T, Glowacka W, Griffiths AM,
Safety and efficacy of cyclophosphamide for the
Ngan B-Y, Lan H, Xu W, Silverberg MS, Rotin D
treatment of paediatric multiple sclerosis. Makhani N
Curative cures? Lee Chong A, Grant R, Ahmed B,
Thomas K, Connolly B, Greenberg M
Is perceived injury risk a barrier to physical activity
participation in children? Mistry N, Birken CS, Parkin P
CD8 lymphopenia and Omenn syndrome. Lavine E,
Kavadas F, Atkinson AR, Grunebaum E, Roifman CM
Mistry N, Core Paediatrics
Nahum A, Immunology and Allergy
Mallik M, Nephrology
Chronic mucocutaneous candidiasis clinical and
The neuronal guidance cue slit 2 impairs monocyte
laboratory classification. Nahum A, Roifman CM
Lewis P, Neonatology
chemotaxis while preserving macrophage
Effects of prolonged exposure to inhaled nitric oxide
phagocytosis. Mallik M, Rui-Crow M, Yan H,
Nashed A, Respiratory Medicine
(INO) on established chronic hypoxic pulmonary
Chaukos D, Robinson LA
Pulmonary hypertension and sleep disordered
Kantores C, Van Vliet T, McNamara PJ, Jankov RP
Mateo P, Neonatology
A Riekstins, J MacFarlane, T Humpl, I Narang
Lim S, Rheumatology
of abnormal neurological outcome in severe
O’Gorman C, Endocrinology
Osteopenia and osteoporosis already present
hyperbilirubinemia. Mateo PC, Colantinio G,
Appetite-related hormone levels in patients with
in newly diagnosed juvenile systemic lupus
Blaser S, Moore AM
craniopharyngioma and hypothalamic obesity.
hypertension in neonatal rats. Lewis P, Xu E,
breathing in children. A Nashed, S Al-Saleh,
Magnetic resonance imaging (MRI) in prediction
erythematosus (JSLE) patients. Lim SH,
O’Gorman CS, Simoneau-Roy J, Pencharz P,
Tyrrell P, Benseler S, Silverman ED
Adeli K, Hamilton J
182 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
Parkash S, Clinical and Metabolic Genetics
Principi T, Paediatric Emergency Medicine
Seltz LB, Paediatric Medicine
Van Allen-Myhre syndrome: report of a new case
What happens to oxygen saturation after discharge
Do children with complex febrile seizures require
with chondrodysplasia punctata. Parkash S, Keating S,
in outpatients with acute bronchiolitis? Principi T,
routine lumbar puncture to exclude bacterial or
Kolomietz E, Toi A, Chitayat D
Coates A, Parkin P, Da Silva Z, Schuh S
herpes simples virus (HSV) meningitis/encephalitis?
Seltz LB, Cohen E, Weinstein M
Parker M, Paediatric Emergency Medicine
Raju D, Gastroenterology
Predictors of major intervention in infants with
Expression of fractalkine (CX3CL1) and its
bronchiolitis. Parker MJ, Allen UD, Lalani A,
involvement in helicobacter pylori infection.
Prevalence of microcytic anaemia in children 12 to 38
Stephens D, Schuh S
Raju D, Terebiznik M, Tole S, Robinson L, Jones N
months of age assessed by suspected child abuse
Pasic I, Clinical and Metabolic Genetics
Rimon Babad A, Paediatric Emergency Medicine
Contribution of DNA copy-number variation (CNV)
Paediatric omental infarction. Rimon Babad A,
to cancer susceptibility and large-scale genome
Gerstle JT, Daneman A, Ratnapalan S
Sharma N, Paediatric Medicine
and neglect team at The Hospital for Sick Children.
alterations in osteosarcoma (OS). Pasic I, Shlien A,
Sharma N, Shouldice M, Mekky M, Parkin P
Sherlock M, Gastroenterology, Hepatology and Nutrition
Infliximab maintenance therapy in paediatric
Novokmet A, Pinto D, Scherer SW, Malkin D
Scheinemann K, Haematology/Oncology
Crohn’s disease: the impact of discontinuation
High morbidity but low mortality in childhood spinal
of concomitant immunomodulation. Sherlock M,
Phongsamart W, Infectious Diseases
cord low grade gliomas. Scheinemann K, Bartels U,
Benchimol EI, Walters T, Turner D, Zachos M, Griffiths AM
Cytomegalovirus in paediatric haematopoietic stem
Huang A, Hawkins C, Bouffet E, Tabori U
cell transplantation at The Hospital for Sick Children,
Shlien A, Haematology/Oncology
2003-2007. Phongsamart W, Doyle J, Gasses A,
Schmeling H, Rheumatology
Excessive germline copy number variations in the
Tellier R, Grunebaum E, Allen U
Nail fold capillary density is strongly associated over
Li-Fraumeni cancer predisposition disorder. Shlien A,
time with muscle and skin disease activity in juvenile
Tabori U, Pienkowska M, Marshall CR, Nanda S,
Porepa M, Core Paediatrics
dermatomyositis. Schmeling H, Stephens S, Goia C,
Druker H, Novokmet A, Feuk L, Scherer SW, Malkin D
Evaluating the impact of a child-driven health
Manlhiot C, Schneider R, Luthra S, Feldman BM
magazine with children from an urban, multicultural,
Smile S, Developmental Paediatrics
low-income elementary school. Porepa M, Huber JF,
Schneiderman-Walker J, Respiratory Medicine
Randomized control study of melatonin for
Lam C, Mekky M, Au H, Birken CS
Assessment of body composition in paediatric
children with autism and sleep difficulties.
patients with cystic fibrosis. Schneiderman-Walker J,
Smile S, Roberts W, Weiss S
Heale L, Wells GD, Wilkes DL, Ratjen F, Coates AL
THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 183
So J, Clinical and Metabolic Genetics
Tanaka T, Clinical Pharmacology and Toxicology
Wells G, Respiratory Medicine
The CYLD tumour suppressor sensitizes cells
The incidence of poor neonatal adaptation syndrome
Skeletal muscle abnormalities in cystic fibrosis.
to microtubule destabilization. So J, Huber M,
following exposure to venlafaxine in late pregnancy.
Wells GD, Wilkes DL, Schneiderman-Walker J
Kohler A, Krauss S, Schweiger S, Schneider R
Tanaka T, Choi J, Einarson A, Koren G, Ito S
Rayner T, Elmi M, Selvadurai H, Ratjen F,
Noseworthy M, Tein I, Coates A
Soylu H, Neonatology
Truong T, Haematology/Oncology
Rupture of membranes before the age of viability
Treatment-related complications in a young girl
Werner K, Neurology
increases adverse outcomes for preterm infants:
with acute lymphoblastic leukaemia may be due to
A MELAS-like phenotype presenting with ND3
a case control study. Soylu H, Diambomba Y,
uncovered mutations in the PKD1 and MTHFR genes.
mutations and Rolandic encephalopathy. Werner K
Jefferies A, Shah PS
Truong TH, Nanda S, Meyn MS, Grant R
Sugiyama I, Neurology
Villani A, Core Paediatrics
Williams V, Neonatology
Withdrawal of artificial hydration and nutrition
Synthetic aperture magnetometry-kurtosis
Inherent diagnostic and treatment challenges in
in the NICU: A humane practice in tragic situations.
for presurgical evaluation of tuberous
germinoma of the basal ganglia: a case report and
Williams C, Ives-Baine L, Shah P, Hellmann J
sclerosis complex. Sugiyama I
review of the literature. Villani A, Bouffet E, Blaser S,
Millar B-A, Hawkins C, Bartels U
Yaghoobi M, Clinical and Metabolic Genetics
Nuclear factor (erythroid 2-related) protein 2
Walsh C, Gastroenterology, Hepatology and Nutrition
of gastric cancer: a meta-analysis. Yaghoobi M,
counteracts bile acid-induced hepatotoxicity:
Simulation training in gastrointestinal endoscopy:
Bijarchi R
involvement of ABC transporters. Tan KP,
low versus high fidelity. Walsh CM, Cooper MA,
Wood GA, Yang M, Kosuge K, Ito S
Rabeneck L, Carnahan H
Tan M, Neurology
Waters A, Nephrology
loss in 60% oxygen-induced neonatal rat lung injury.
Alleviation of cerebral venous obstruction in supine
Slit diaphragm defects precede proteinuria
Yi M, Masood A, Jankov R, Tanswell AK
Tan KP, Clinical Pharmacology and Toxicology
Impact of family clustering on the risk of development
Yi M, Neonatology
Inhibition of neutrophil influx protects against vessel
lying neonates with use of a custom-designed pillow.
in podocyte-specific notch-ic transgenic mice.
Tan M, Kirton A, Miller E, Shroff M, Deverber G
Waters A, Wu M, Onay T, Piscione T
184 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT
555 University Avenue
Toronto, ON, Canada M5G 1X8
www.sickkids.ca
Phone: 416.813.6122
For electronic versions of
Department of Paediatrics’
annual reports, please see
www.sickkids.ca/paediatrics

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Math 180B, Winter 2015 Homework 7 Solutions Ex. 4.2.2. In this