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Department of Paediatrics
The Hospital for Sick Children
ANNUAL REPORT 2006-07
Developing new
health strategies
CONTENTS
02 Chair’s Report
Divisions
04 Adolescent Medicine
08 Cardiology
18 Clinical and Metabolic Genetics
24 Clinical Pharmacology and
Toxicology
29 Developmental Paediatrics
32 Endocrinology
36 Gastroenterology, Hepatology
and Nutrition
44 Haematology/Oncology
56 Immunology/Allergy
61 Infectious Diseases
66 Neonatology
74 Nephrology
78 Neurology
86 Paediatric Emergency
Medicine
94 Paediatric Medicine
102 Respiratory Medicine
107 Rheumatology
113 Bloorview Kids Rehab
115
116
118
122
PAMOT
Paediatric Housestaff
Paediatric Grand Rounds
Promotions/Retirements/
Service Recognition
124 Faculty Awards
126 Resident and Fellow Awards
and Achievements
Introduction
Dedicated to improving children’s
health through advances in
clinical care and research and the
education of future caregivers.
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
1
Chair’s Report
On July 1, 2006, Hugh O’Brodovich stepped down after 10 outstanding years of leadership of the
Department of Paediatrics at The Hospital for Sick Children (SickKids) and the University of Toronto
(U of T). The transition has been smooth, in large part because of the commitment of Hugh and his team
to academic excellence and fiscal responsibility. The 2006-07 academic year was one of ongoing high
achievement in all aspects of academic paediatrics. This annual report attests to the magnificent nature
of the Department’s accomplishments.
What are the metrics of success? In research, they are
The challenges of the past year have included recruitment
relatively easily identified: more than 700 papers published
of new faculty to fill vacancies due to retirement, departures
annually, frequent invitations to faculty for plenary lectures
and new opportunities. So far, about 20 new faculty
at prestigious meetings or visiting professorships,
members have joined the Department across nearly all of
increasing grant funding (the vast majority of our faculty
the divisions. Furthermore, a number of Division Heads
has some funding to support their research) and increasing (Chaim Roifman, Immunology, Andrew Redington, Cardiology
numbers of research trainees.
and Denis Geary, Nephrology) have been reappointed
In education, we completed the Royal College of Physicians
and Surgeons of Canada external review with overall good
success, attracted a superb cohort of core paediatric
residents and an ever increasing number of subspecialty
and a new one appointed (Mark Palmert, Endocrinology).
Our new recruits represent an enormously accomplished
and talented group of people from all around the world.
We have great expectations!
trainees. Last year, there were about 60 residents, 60
Another challenge has been the protracted, but eventually
Royal College approved trainees in subspecialty programs,
successful, renegotiation of our Alternate Funding Plan with
and 209 other trainees in both clinical and research
the Ministry of Health and Long-Term Care. The new plan,
programs. Increasing numbers of our faculty have taken
although relatively short in duration, allows us to maintain
education as their career path either doing a Masters in
Education or the Education Scholars Program at the Centre
fiscal stability and remain competitive.
for Faculty Development at the University of Toronto.
Finally, clinically, we continue to provide outstanding
tertiary and quaternary care to the children of Ontario,
partner with the paediatric academic health science
centres in Ontario (as part of the relatively new Provincial
Council for Children’s Health, PCCH) and community
programs (in the context of the Child Health Network of
the GTA).
2
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
The major changes in leadership at the level of the
Paediatric Executive have been the move of Susan Tallett
to Director of the SickKids Learning Institute and her
replacement by Rayfel Schneider, and the addition of
Ben Vozzolo as Director of Administrative Services in the
Department of Paediatrics. Rayfel’s mandate is to oversee
all of the educational activities of the Department and
ensure that we remain at the cutting edge of educational
activities. Rayfel’s team includes new Program Directors in
both Postgraduate (Adelle Atkinson) and Undergraduate
(Stacey Bernstein) Medical Education, as well as Suzan
Schneeweiss, Director of Continuing Education. New
directions in education can be expected from this highly
talented and enthusiastic group. Ben has more than ably
taken over where Rich Gerber left off, overseeing the
department’s financial well-being and supporting the
administrative staff across all of the divisions.
The next steps for our department include: completion of
the reevaluation of our Career Development and
Compensation Program, and development of our strategic
goals with alignment with those of SickKids and the
University of Toronto. This has begun and will culminate
later this year in transparent processes and plans.
In the meantime, the Department of Paediatrics remains
highly accomplished and productive, though not without
its stresses and strains. I am greatly indebted to all
members of the department for their hard work this past
year and for the patience and encouragement they have
all offered me. Special thanks to the Paediatric Executive,
Daune MacGregor, Norman Rosenblum, Sue Tallett
and Ben Vozzolo, and to the hospital administration,
Mary Jo Haddad, CEO and President, Seonag Macrae,
VP Child Health Services Portfolio, and Ron Laxer,
VP Education and Quality, and Dean Cathy Whiteside
of the University of Toronto’s Faculty of Medicine for
their enormous support.
DENIS DANEMAN, MB, BCh, FRCPC
Chair of Paediatrics University of Toronto
Paediatrician-in-Chief, The Hospital for Sick Children
R.S. McLaughlin Chair in Paediatrics at The Hospital for Sick Children
THE PAEDIATRIC EXECUTIVE COMMITTEE
Left to right: Ms. Seonag Macrae, Dr. Daune MacGregor, Mr. Ben Vozzolo,
Dr. Denis Daneman, Dr. Norman Rosenblum, Dr. Susan Tallett
Division Head
Dr. Debra K. Katzman
Full-Time
Dr. Eudice Goldberg
Dr. Miriam Kaufman
Dr. Karen Leslie
Dr. Cathleen Steinegger
Part-Time
Dr. Michael Falk
Dr. Miriam Rossi
Dr. Rahul Saxena
Clinical Fellows
Dr. Fadia Al-Buhairan
Dr. Rosawan Areemit
Dr. Boonying
Manaboriboon
Dr. Ellie Vyver
Administrative Staff
Sawsan Bakhit
Ursula Pajak
Burnett Wint
Adolescent Medicine
DIVISIONAL OVERVIEW
Drs. Karen Leslie and Miriam Kaufman with Adolescent Medicine Team
The Division of Adolescent Medicine continues to focus its
clinical activities in five program areas – Eating Disorders,
The Good 2 Go Transition Program, Substance Abuse, Young
Families, and Complex Adolescent Problems.
The Eating Disorders Program at The Hospital for Sick Children
continues to be the provincial centre for child and adolescent
eating disorders providing a variety of integrated clinical services
(inpatient, day treatment, outpatient and consultation) to
adolescents and their families. Over the past year, the Ministry
of Health and Long-Term Care (MOHLTC) granted new funding to
enhance intensive inpatient services for children and
adolescents with eating disorders at SickKids. In addition, other
new initiatives include the integration of multi-family group
therapy at SickKids and throughout the province. Over the past
year, these year-long groups were completed in three provincial
centers. In the fall of 2007, SickKids will lead in providing multifamily group therapy training to professionals from several
centres and will continue to provide groups to families at the
hospital. The collaborative Ontario Community Outreach Program
(SickKids, University Health Network and the MOHLTC) continues
to train health care professionals around the province in the
assessment and treatment of eating disorders and has been an
extremely successful educational initiative.
A smooth transition from paediatric to adult health care is a
priority for all SickKids patients. The Good 2 Go Transition Team,
consisting of a Nurse Practitioner, Psychologist, Social Worker
and Paediatrician, has made tremendous strides since its
inception in August 2006. The team runs a weekly transition
clinic in Adolescent Medicine, as well as being involved with
transition clinics in other parts of the hospital. There have been
meetings with over 15 clinical programs, most of which have
already adopted new transition activities. Launched in January
2007, the Good 2 Go website offers a constantly expanding
transition bibliography, a transition menu, and links to various
resources. MyHealth Passport is a wallet-sized card with health
information that is created by a teen with a health care provider,
the process combining patient education and empowerment with
a tool for sharing health information. A comprehensive transition
intervention and research study is being developed with the
Division of Cardiology.
The Adolescent Substance Abuse Outreach Program and the
Substance Abuse Day Treatment Program continue to provide
exemplary clinical care to adolescents and their families with
substance abuse problems. In-depth psychotherapy, brief
counseling, group work and family support are fundamental
services offered to our patients. As well, all patients receive
regular medical assessments to assess for medical sequelae of
their substance use and other medical concerns that result
from a high-risk lifestyle. The program recently completed a sixmonth pilot project with the Department of Psychiatry, providing
substance abuse training for child-track residents and receiving
psychiatric assessment and treatment for co-morbid psychiatric
diagnoses for adolescents in the Program. Due to the success of
the pilot project, a second six-month program is underway.
The Day Treatment Program expanded their services this year to
include a summer program, combining treatment, academic and
medical support to day treatment patients. All Substance Abuse
Program staff work collaboratively with many other organizations to
provide comprehensive care to at-risk youth. Staff members also
provide extensive education at many levels including trainees from
a variety of disciplines, staff in other areas of the hospital, health
care professionals and other professionals in the community as
well as adolescents and their caregivers. Expanded training
initiatives have been implemented for Adolescent Medicine fellows
and for staff in the Emergency Department. As well, enhanced
training in substance use and abuse for paediatric residents will
be initiated this academic year. In addition to the many outreach
educational activities of the Program, staff presented at
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
5
international conferences in New Zealand and Australia at the
invitation of local health care professionals. Members of our
staff are involved in many aspects of service development, both
at local and regional levels, and provide expertise in child and
youth substance use and abuse to various committees
dealing with prevention and treatment issues at the municipal,
provincial, and national levels.
The Complex Adolescent Patient Program (CAPP) continues
to focus on adolescents with a chronic illness or disability.
These services are provided in the Teen Clinic as well as in
collaboration with renal, cardiac and lung transplant clinics,
HIV clinic, SLE clinic and through inpatient consultations.
This past year, a combined CAPP/SCAN clinic has been
established to collaboratively assess and provide education
and support for adolescents identified as engaging in highrisk sexual behaviours. The CAPP clinic has formalized an
advocacy, outreach partnership with St. Stephen’s Community
House to enable youth in the downtown core to access health
information and necessary health services otherwise unavailable
to them. The goal of the clinic is to reduce high-risk health
behaviours, as well as to prevent pregnancy, sexual assault and
sexually transmitted infections by promoting healthy sexuality
and safe sexual relationships. Public education is an important
part of CAPP and is delivered through talks at schools and to
parent groups, media interviews and publications.
The Young Families Program (YFP) continues to focus on
providing health care, advocacy, support and education to highrisk adolescent parents and their children. The YFP collaborates
with several agencies that provide services to high-risk
adolescent parents including prenatal homes, health services
and child protection agencies. In Particular the YFP provides a
consultation clinic at “Jessie’s Centre for Teenagers” and
provides educational, supportive and policy recommendations.
In partnership with the SCAN team the “High Risk Project” has
been operational since 2004 when external funding was
established to standardize clinical care for adolescent parents
and their children. Assessment and intervention in the areas of
growth and development, infant and adolescent mental health,
6
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
maltreatment, and social determinants of health provide the basis
for research in adolescent parenting. Inter-disciplinary team
members continue to disseminate information and provide
education to health professionals in a variety of settings through
workshops, poster presentations, and clinical practice guidelines.
Research activities are an integral part of the activities of the
faculty and trainees of the Division. Each of our clinical areas
provides the substrate for our clinical research endeavours in
the Division. As such, research activities include the medical
complications of eating disorders with specific emphasis on
osteoporosis, epidemiology of early-onset eating disorders,
evaluation of family-based treatment for adolescents with eating
disorders, the evaluation of the use of information technology for
health promotion with youth, treatment outcomes in adolescent
substance use, HIV educational interventions with incarcerated
youth, and health values in adolescents with chronic illnesses.
Members of the Division continue to make significant educational
contributions locally, provincially, nationally and internationally.
Members of our division hold leadership roles in the SickKids
Summer Student Program, co-ordination of the Mentorship
Program for Clinician-Teachers and -Educators at the Centre for
Faculty Development, and the organization of the international
annual scientific meeting on adolescent health at the Society
for Adolescent Medicine.
Division members play a leading role in national and international
clinical, education and research committees including the Infant
Mental Health Promotion Project, Canadian Paediatric Society,
American Academy of Pediatrics, Society for Adolescent Medicine,
Canadian Association for Medical Education and Academy for
Eating Disorders.
Over the past three years, the Division has taken the lead in
pursuing paediatric subspecialty certification for Adolescent
Medicine through the Royal College of Physicians and Surgeons
of Canada (RCPSC). Adolescent Medicine was endorsed at
the RCPSC’s Council in May 2007, and will now become the
63rd recognized discipline of the RCPSC as a subspecialty
of Paediatrics.
HONOURS AND AWARDS
Katzman DK: Elected Treasurer for the Academy
for Eating Disorders, 2007-2010.
Katzman DK: Chair, Adolescent Medicine
Subspecialty Working Group Committee, Royal
College of Physicians and Surgeons of Canada
PUBLICATIONS
Adolescent Health Committee (Leslie K, et al.):
Adolescent pregnancy – CPS Position Paper.
Paediatrics & Child Health 2006: 11: pp 243-246.
American Academy of Pediatrics, Committee on
Adolescence, American College of Obstetricians
and Gynecologists, and Committee on Adolescent
Health Care: Menstruation in girls and
adolescents: Using the menstrual cycle as a vital
sign. Pediatrics 2006: 118: pp 2245-2250.
Blythe MJ and the Committee on Adolescence:
Emergency contraception. Pediatrics 2005: 116:
pp 1026-1035.
Bell M: Book Review: Protecting children from
domestic violence: Strategies for community
intervention. Canadian Journal of Community
Mental Health 2007: 26: pp 1-4.
Committee on Injury, Violence, and Poison
Prevention and Committee on Adolescence: The
teen driver. Pediatrics 2006: 118: pp 2570-2581.
Goldberg MB, Katzman DK, Woodside B, Baker GI:
Do eating disorders and chronic facial pain
coexist? A preliminary study. J Can Dent Assoc.
2006: 72: p 51.
Katzman DK, Walker LR, Rickert VI, Lock J: Invited
commentary: The Year 2004: A depressing
year for the treatment of depression adolescence.
Journal of Adolescent Health 2005: 36:
pp 454-456.
Kaufman M: Transition of cognitively delayed
adolescent organ transplant recipients to adult
care Pediatric Transplantation 2006: 10:
pp 413-417.
Korczak D, MacArthur C, Katzman DK: Canadian
paediatric residents’ experience and level of
comfort with adolescent gynecological health
care. Journal of Adolescent Health. 2006: 38:
pp 57-59.
Korczak D, Connolly B, Baron T, Katzman DK,
Bernstein S: Safety and efficacy of image-guided
gastrostomy (G) and gastrojejunostomy (GJ) tubes
in children and adolescents with primary
psychiatric illness. International Journal of Eating
Disorders June 21, 2007 [Epub ahead of print].
Misra M, Miller KK, Cord J, Prabhakaran R,
Goldstein M, Katzman DK, Herzog DB, Klibanski A:
Relationships between serum adipokines, insulin
levels and bone density in girls with anorexia
nervosa. Journal of Clinical Endocrinology
and Metabolism March 13, 2007 [Epub ahead
of print].
Kirsh G, McVey G, Tweed S, Katzman DK:
Psychosocial profiles of young adolescent females
seeking treatment for an eating disorder. Journal
of Adolescent Health 2007: 40: pp 351-356.
Kohn M, Rees JM, Brill S, Fonseca H, Jacobson M,
Katzman DK, Loghmani ES, Neumark-Sztainer D,
Schneider M: Preventing and treating adolescent
obesity: Position paper of the Society for
Adolescent Medicine. Journal of Adolescent
Health 2006: 38: pp 784-787.
Pinhas L, Steinegger C, Katzman DK: Clinical
assessment and physical complications. In: Eating
Disorders in Childhood and Adolescence 3rd
Edition. Lask B, Bryant-Waugh R (ed). London,
Brunner-Routledge, 2006.
AUDIO EDUCATIONAL PROGRAM
Katzman DK, Golden NH, Kreipe RE: Eating
disorders in adolescents. In: Critical Conversations
with Pediatric Experts (Metzl K, ed). PrepAudio
Vol 2: No 2: American Academy of Pediatrics,
2007.
FUNDING
Norris M, Boydell KM, Pinhas L, Katzman DK: Ana
and the internet: A review of pro-anorexia
websites. International Journal of Eating Disorders
2006: 39: pp 443-447.
Pawelski J, Perrin E, Foy J, Allen C, Crawford J, Del
Monte M, Kaufman M, Klein J, Smith K, Springer
S, Tanner J, Vickers D: The effects of marriage,
civil union, and domestic partnership laws on the
health and well-being of children. Pediatrics
2006: 118: pp 349-364.
Richardson D, Glover Takahashi S, Nasmith L,
Leslie K, Bandiera G, Paterson M, Power B,
Oandason I, Frank JR: The CanMEDS Ttrain-theTrainer Collaborator Faculty Development Program.
Ottawa: The Royal College of Physicians and
Surgeons of Canada, 2007.
Richard P. Millman and the Working Group on
Sleepiness in Adolescents/Young Adults; and AAP
Committee on Adolescence. Excessive sleepiness
in adolescents and young adults: Causes,
consequences, and treatment strategies.
Pediatrics 2005: 115: pp 1774-1786
BOOKS AND BOOK CHAPTERS
Kaufman M: Role of adolescent development in
the transition process. Progress in transplantation.
2006: 16: pp 286-290.
Pinhas L, Katzman DK, Dimitropoulos G,
Woodside B: Binging and bulimia nervosa in
children and adolescents. In: Child and
Adolescent Eating Disorders (Jaffa T, McDermott
B, eds). Cambridge: Cambridge University
Press, 2007.
Wraith JE, Clarke JTR: The
mucopolysaccharidoses. In: Physician’s Guide to
the Treatment and Follow-up of Metabolic
Diseases (Blau N, Hoffmann GF, Leonard J, Clarke
JTR, eds). Springer-Verlag, Berlin, 2006.
Adolescent Health Care: A Practical Guide, Fifth
Edition (Neinstein L, Gordon C, Katzman DK,
Rosen D, Woods E, eds). Philadelphia: Lippincott
Williams & Wilkins, 2007.
Effects of Anorexia Nervosa on Peak Bone Mass.
Klibanski A, Katzman DK, Misra M, Herzog D,
Levitsky L. National Institute of Health/National
Institute of Diabetes and Digestive & Kidney
Diseases ($3,801,660 2003-2008)
Family therapy and fluoxetine in the treatment of
adolescent anorexia nervosa. Agras S, Brandt H,
Halmi K, Johnson C, Kaye W, Wilfley D, Woodside
B, Pinhas L, Katzman DK. National Institute of
Mental Health (TGH and SickKids site: $675,000
funds released with REB approval for 5 years;
Total: $6,250,000 over five years)
Positive Youth Project Capacity Building Grant.
Canadian AIDS Treatment Information Exchange.
Flicker S, Read S, Goldberg E, Skinner H, Veinot T,
Taylor D & McClellan A. Ontario HIV Treatment
Network ($25,000 2006-2007)
Leadership: “Creating Communities of Practice for
Interprofessional Collaboration (IPC) in Toronto”
Kwan D, Leslie K, Lieff S, Nasmith L, Oandasan I,
Reeves S, Silver I. Central project for a larger
initiative funded by: Ministry of Health and LongTerm Care Interprofessional, Mentorship,
Preceptorship, Leadership and Coaching Fund
($3,400,000 2007)
A Longitudinal Impact Evaluation of the Centre for
Faculty Development’s Stepping Stones Certificate
Program: Educator Identity and Professional
Networks. Richardson D, Wagner S, Dionne A,
Leslie K, Reeves S. University of Toronto
Continuing Education Research and Development
Fund ($5,000 2006)
Katzman DK, Golden NE: Eating disorders. In:
Adolescent Health Care: A Practical Guide, Fifth
Edition (Neinstein L, Gordon C, Katzman DK,
Rosen D, Woods E, eds). Philadelphia: Lippincott
Williams & Wilkins, 2007.
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
7
Cardiology
DIVISIONAL OVERVIEW
Over the past decade, the Divisional activities, in close
collaboration with surgical and intensive care colleagues, have
contributed to our markedly improved preoperative diagnosis
and postoperative outcomes for children undergoing cardiac
surgery, led the field in development of therapeutic catheter
techniques, made important contributions to our understanding
of fetal cardiac medicine, established one of the largest
paediatric cardiac transplantation centres worldwide, and has
won international recognition for its contribution in the field of
epidemiology of acquired and congenital heart disease and
surgical outcomes. Each of these areas has provided the
substrate for the large clinical research output of the Division
which is underpinned by our world-class laboratory science
program. One of the most exciting clinical developments has
been the recent commissioning of an integrated suite of catheter
laboratories and magnetic resonance scanning facility. This
unique fusion will allow �simultaneous’ multi-mode investigation
and treatment, setting the scene for MRI-guided interventional
procedures in children, and providing for unique physiologic
insights into cardiovascular disease. This philosophy of clinical,
academic and administrative integration led to formation of the
Labatt Family Heart Centre in 2007, with major new financial
support for the formation of chairs and fellowships, development
of infrastructure, and the endowment of an innovation fund
providing internal revenue for seed-funding and Heart Centresponsored thematic research.
Division Head
Dr. Andrew Redington
Full-Time
Dr. Lee Benson
Dr. Tim Bradley
Dr. Rajiv Chaturvedi
Dr. Anne Dipchand
Dr. Mark Friedberg
Dr. Fraser Golding
Dr. Gil Gross
Dr. Robert Hamilton
Dr. Edgar Jaeggi
Dr. Paul Kantor
Dr. Joel Kirsh
Dr. Kyong-Jin Lee
Dr. Brian McCrindle
Dr. Seema Mital
Dr. Jennifer Russell
Dr. Elizabeth
Stephenson
The cardiovascular research focus within the Research Institute
has made fundamental contributions to our understanding of the
cellular biology and molecular genetics of pulmonary vascular
bed, with recent diversification to include the study of the fetal
myocardial development, and developmental genetics, detailed
study of the intercellular structure of the heart and vessels,
electrophysiology of the developing heart and immunology of
cardiac transplantation. While undergoing a change in leadership,
it is expected that high quality basic and translational research,
with an emphasis on direct clinical applicability, will continue to
form the bedrock of our academic program.
Finally, the Royal College accredited Paediatric Cardiology Training
Program, is the largest in Canada and one of the largest and
most sought after in North America. As such, its fellows have
populated cardiology groups throughout the world, many going on
to become leaders of our specialty.
Part-Time
Dr. Tiscar CavalleGarrido
Dr. Jack Colman
Dr. Rejane Dillenburg
Dr. Alexandra
Jevremovic
Dr. Anilkumar Menon
Dr. Mark Friedberg
The Division of Cardiology was formally established in the
1940’s and is now one of the largest and most successful in
the world. Its philosophy has remained unchanged since its
inception over sixty years ago; to provide the highest quality
care in an evidence-based environment of clinical innovation
and scientific discovery.
Dr. Norman Musewe
Dr. Lynne Nield
Dr. Rachel Wald
Dr. Roxanne Walker
Adjunct
Dr. Fred Keeley
(Research Scientist)
Cross-Apointees
Dr. Tilman Humpl
Dr. Steven Schwartz
Dr. Ben Sivarajan
Dr. Shi-Joon Yoo
Clinical Fellows
Dr. Abdulmajeed
Al-Otay
Dr. Merna Atiyah
Dr. JosГ©
Castro-Sancho
Dr. Robin Clegg
Dr. Gaute DГёhlen
Dr. Scott Fox
Dr. Brian Grant
Dr. Lars GrosseWortmann
Dr. Ra Han
Dr. Nasser Moiduddin
Dr. Masaki Osaki
Dr. Lucy Roche
Dr. Imran Sajan
Dr. Mark Walsh
Dr. Roland Weber
Departmental
Clinical Fellows
Dr. Alex Gooi
Dr. Dragos Predescu
Research Fellows
Dr. Kentaro Asoh
Dr. June Huh
Dr. Maria Ilina
Dr. Jon Lee
Research Associates
Dr. Jia Li
Dr. Jing Li
Subspecialty
Residents
Dr. Matthew Crystal
Dr. Alejandro Floh
Dr. Deborah Fruitman Paula Capela
Dr. Derek Wong
Esther Delea
Dr. Marko Vezmar
Karen Hodgson
Susan Jessop
Administrative Staff
Shelley Marks
Iris Biberstein
Fran Matthews
Theresa Braggs
Shloka Mirchandaney
Sandra Brisebois
Andrea Morris
Eleanor Paulino
Rooma Vaidya
Denise Vanek
Linda Vorano
Shirley Wang
HONOURS AND AWARDS
Dr. Anne Dipchand: James C. Fallis Teaching
Award (Invited Speaker), Division of Paediatric
Emergency Medicine, The Hospital for Sick
Children, 2006.
Dr. Paul Kantor: Second Prize, Oral Abstract
Presentation. “Resting cardiac index, ejection
fraction ad exercise capacity in a pediatric heart
failure clinic population”. The Second
International Conference on Heart Failure in
Children and Young Adults, Laguna Niguel,
CA, 2006.
Dr. Paul Kantor: Third Prize, Oral Abstract
Presentation. “Effect of medical therapy and
transplantation on the natural history of pediatric
dilated cardiomyopathy: A 25 year retrospective
study”. The Second International Conference on
Heart Failure in Children and Young Adults,
Laguna Niguel, CA. 2006.
Dr. Dragos Predescu: Third Prize, abstract poster
annual resident research day: “Resting cardiac
index, ejection fraction ad exercise capacity in
a pediatric heart failure clinic population”.
The Second International Conference on Heart
Failure in Children and Young Adults, Laguna
Niguel, CA. 2006
PUBLICATIONS
Akikusa JD, Feldman BM, Gross GJ, Silverman ED,
and Schneider R: Sinus bradycardia following
intravenous �pulse’ methylprednisolone. Pediatrics
2007: 119: pp e778-e782.
Aleem IS, Karamlou T, Benson LN, McCrindle
BW: Transcatheter device versus surgical closure:
A clinical decision analysis. Catheterization
and Cardiovascular Interventions 2006: 67:
pp 630-636.
Alpert B, McCrindle B, Daniels S, Dennison B,
Hayman L, Jacobson M, Mahoney L,
Rocchini A, Steinberger J, Urbina E, Williams R:
Recommendations for the blood pressure
measurement in human and experimental
animals: Part 1: Blood pressure measurement
in humans (Letter) Circulation 2006 48: p e3.
Dr. Fraser Golding and trainees
Al-Radi OO, Caldarone CA, McCrindle BW, Jacobs
JP, Williams G, Williams WG, Van Arsdell GS: Case
complexity scores in congenital heart surgery:
A comparative validation study of the Aristotle
Basic Complexity score and the Risk Adjusted
Congenital Heart Surgery (RACHS-1) scoring
system. Journal of Thoracic and Cardiovascular
Surgery 2007 133: pp 865-875.
Alsenaidi K, Gurofsky R, Karamlou T, Williams WG,
McCrindle BW: Management and outcomes
of double aortic arch in 81 patients. Pediatrics
2006: 118: pp e1336-e1341.
Alsoufi B, Karamlou T, Bradley TJ, Williams WG,
Van Arsdell GS, Coles JG, Smallhorn JF, Nii M,
Guerra V, Caldarone CA: Midterm Results of Aortic
Valve Cusp Extension in the Treatment of Children
with Aortic Insufficiency. Annals of Thoracic
Surgery 2006: 82: pp 1292-1299.
Alsoufi B, Karamlou T, McCrindle BW, Caldarone
CA: Decision making in critical left ventricular
outflow tract obstruction in neonates and infants.
European Journal of Cardio-Thoracic Surgery 2007
31: pp 1013-1021.
Alsoufi B, Karamlou T, Osaki M, Badiwala MV,
Ching CC, Dipchand A, McCrindle BW, Coles JG,
Caldarone CA, Williams WG, Van Arsdell GS:
Surgical repair of multiple ventricular septal
defects: the role of re-endocardialization strategy.
Journal of Thoracic and Cardiovascular Surgery
2006: 132: pp 1072-1080.
Anand N, McCrindle BW, Chiu-Man C, Hamilton
RM, Kirsh JA, Stephenson E, and Gross GJ:
Chronotropic incompetence in young patients
with late postoperative atrial flutter: A case-control
study. European Heart Journal 2006: 27:
pp 2069-2073.
Bernasconi A, Yoo SJ, Golding G, Langer JC,
Jaeggi ET: Etiology and outcome of prenatally
detected paracardial cystic lesions. Ultrasound
in Obstetrics and Gynecology 2007: 29:
pp 388-394.
Bradley TJ, Alman B, Levin A, Chitayat D: Marfan
syndrome. Parkhurst Exchange 2006: 14:
pp 88-93.
Bronzetti G, Chiu C, Stephenson E, Hamilton R,
Gross G, Gao D, Neilson A, Kirsh JA:
Simultaneous wide and narrow QRS complex
tachycardias in a child: what is the mechanism?
Journal of Cardiovascular Electrophysiology 2006:
17: pp 560-582.
Crystal M, Benson L, Mikailian H: Catheter-based
completion of the Fontan circuit: A non-surgical
approach. Circulation 2006: 114: pp e5-e6.
Dong-Sheng G, Wei-yi F, Chiu-Man C, Kirsh J,
Gross G, Hamilton RM: QT hysteresis in long-QT
syndrome children with exercise testing. Chinese
Medical Journal 2007: 120: pp 179-182.
Fernandez-Martorell P, Yoo S-J, Benson LN: An
unusual form of anomalous systemic arterial
supply to the left lung. Cardiology in the Young
2006: 16: pp 305-307.
Friedberg MK, Bernheimer J, Chan FP, Silverman
NH: Echocardiographic diagnosis of persistent
fifth aortic arch. echocardiography 2007: 24:
pp 258-262.
Friedberg MK, Chang I, Silverman NH,
Ramamoorthy C, Chan FP: Images in
cardiovascular medicine. Near sudden death
in an adolescent from a cardiac lipoma.
Circulation 2006: 113: pp e778-e779.
Friedberg MK, Feinstein JA, Rosenthal DN: A novel
echo-doppler method for estimation of pulmonary
arterial pressures. Journal of the American Society
of Echocardiography 2006: 19: pp 559-562.
Friedberg MK, Feinstein JA, Rosenthal DN: Noninvasive assessment of pulmonary arterial
capacitance by echocardiography. Journal of the
American Society of Echocardiography 2007: 20:
pp 186-190.
Friedberg MK, Silverman NH: Cardiac ventricular
diastolic and dystolic duration in children with
heart failure secondary to idiopathic dilated
cardiomyopathy. American Journal of Cardiology
2006: 97: pp 101-105.
Chaturvedi RC, Redington AN: Pulmonary
regurgitation in congenital heart disease. Heart
2007: 93: pp 880-889.
Friedberg MK, Silverman NH: The systolic to
diastolic duration ratio in children with hypoplastic
left heart syndrome: A novel doppler index of
right ventricular function. Journal of the American
Society of Echocardiography 2007: 20:
pp 749-755.
Chiu CC, Hamilton RM, Gow RM, Kirsh JA,
McCrindle BW: Evaluation of computerized
interpretation of the paediatric electrocardiogram.
Journal of Electrocardiology 2007: 40:
pp 139-143.
Friedberg MK, Silverman NH, Dubin AM, Rosenthal
DN: Mechanical dyssynchrony in children with
systolic dysfunction secondary to cardiomyopath:
A Tissue. Journal of the American Society
of Echocardiography 2007: 20: pp 756-763.
Cho JY, Min JY, Yoo SJ, McCrindle BW, Hornberger
LK, Lee YH: Normal thymus diameter at
fetal ultrasound. Ultrasound in Obstetrics and
Gynecology 2007: 29: pp 634-638.
Gao DS, Fang WY, Chiu-Man C, Kirsh J, Gross G,
Hamilton RM: QT hysteresis in long-QT syndrome
children with exercise testing. Chinese Medical
Journal (England) 2007: 120: pp 179-182.
Collins KK, Rhee EK, Kirsh JA, Cannon BA, Fish F,
Dubin A, Van Hare GF: Cryoablation of accessory
pathways in the coronary sinus in young patients:
A multicenter study from the Pediatric and
Congenital Electrophysiology Society’s Working
Group on Cryoablation. Journal of Cardiovascular
Electrophysiology 2007: 18: pp 592-597.
Gross GJ: IK1: The long and the short QT of it.
Heart Rhythm 2006: 3: pp 336-338.
Gross GJ: Bradycardia-mediated ventricular
electrical remodeling. Journal of Cardiovascular
Electrophysiology 2006: 17: pp S178-S182.
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
11
Karamlou T, McCrindle BW, Williams WG: Surgery
insight: Late complications following repair of
tetralogy of Fallot and related surgical strategies
for management. Nature Clinical Practice
Cardiovascular Medicine 2006: 3: pp 611-622.
Grosse-Wortmann L, Al-Otay A, Woo Goo H,
Macgowan CK, Coles JG, Benson LN, Redington
AN, Yoo SJ: Anatomical and functional evaluation
of pulmonary veins in children by magnetic
resonance imaging. Journal of the American
College of Cardiology 2007: 49: pp 993-1002.
Kavey RW, Allada V, Daniels SR, Hayman LL,
McCrindle BW, Newburger JW, Parekh RS,
Steinberger J: Cardiovascular risk reduction in high
risk paediatric patients: A Scientific Statement
from the American Heart Association Expert Panel
on Population and Prevention Science; the
Councils on Cardiovascular Disease in the Young,
Epidemiology and Prevention, Nutrition, Physical
Activity and Metabolism, High Blood Pressure
Research, Cardiovascular Nursing, and the Kidney
in Heart Disease; and the Interdisciplinary Working
Group on Quality of Care and Outcomes Research.
Journal of Cardiovascular Nursing 2007: 22:
pp 218-253.
Harris KC, Potts JE, Fournier A, Gross GJ, Kantoch
MJ, Cote J-M, Sanatani S: A multicenter study
of right ventricular outflow tract tachycardia
in children. Journal of Pediatrics 2006: 149:
pp 822-826.
Herron TJ, Rostkova E, Kunst G, Chaturvedi RR,
Gautel M, Kentish JC: Activation of myocardial
contraction by the N-terminal domains of myosin
binding protein-C. Circulation Research 2006: 98:
pp 1290-1298.
Horenstein MS, Idriss SF, Hamilton RM, Kanter RJ,
Webster PA Jr, Karpawich PP: Efficacy of
signal-averaged electrocardiography in the young
orthotopic heart transplant patient to detect
allograft rejection. Pediatric Cardiology 2006: 27:
pp 589-593.
Ilina MV, Jaeggi ET, Lee K-J: Neonatal
rhabdomyoma causing right ventricular inflow
obstruction with duct-dependent pulmonary blood
flow: successful stenting of PDA. Catheterization
and Cardiovascular Interventions 2007: 69:
pp 881-885.
Kantor PF, Slorach C: Clinical considerations for
Heart Rhythm allied professionals: Understanding
heart failure in congenital heart disease (CHD)
patients. Heart Rhythm Journal 2007: 4:
pp 248-250.
Karamlou T, Blackstone EH, Hawkins JW,
Jacobs ML, Kanter KR, Brown JW, Mavroudis C,
Caldarone CA, Williams WG, McCrindle BW: Can
pulmonary conduit dysfunction and failure
be reduced in infants and children less than age
two years at initial implantation? Journal of
Thoracic and Cardiovascular Surgery 2006: 132:
pp 829-838.
Karamlou T, Gurofsky R, Al Sukhni E, Coles JG,
Williams WG, Caldarone CA, Van Arsdell GS,
McCrindle BW: Independent factors
associated with mortality and reoperation in
377 children with total anomalous pulmonary
venous connection. Circulation 2007: 115:
pp 1591-1598.
Kavey RW, Allada V, Daniels SR, Hayman LL,
McCrindle BW, Newburger JW, Parekh RS,
Steinberger J: Cardiovascular risk reduction in high
risk paediatric patients: A Scientific Statement
from the American Heart Association Expert Panel
on Population and Prevention Science; the
Councils on Cardiovascular Disease in the Young,
Epidemiology and Prevention, Nutrition, Physical
Activity and Metabolism, High Blood Pressure
Research, Cardiovascular Nursing, and the Kidney
in Heart Disease; and the Interdisciplinary Working
Group on Quality of Care and Outcomes Research.
Circulation 2006: 114: pp 2710-2738.
Kharbanda RK, Li J, Konstantinov I, Cheung M,
White P, Frndova H, Stokoe J, Cox P, Vogel M,
Van Arsdell G, Macallister R, Redington AN:
Remote ischemic preconditioning protects against
cardiopulmonary bypass induced tissue injury –
A preclinical study. Heart 2006: 92: pp 1506-1511.
Kim N, Friedberg MK, Silverman NH: Diagnosis
and prognosis of fetuses with double outlet
right ventricle. Prenatal Diagnosis 2006: 26:
pp 740-745.
Kirsh JA, Stephenson EA, Redington AN: Recovery
of left ventricular systolic function after
biventricular resynchronization pacing in a child
with repaired tetralogy of Fallot and severe
biventricular dysfunction. Circulation 2006: 113:
pp 691-692.
Li J, Konstantinov IE, Cai S, Shimizu M, Redington
AN: Systemic and myocardial oxygen transport
responses to brain death in pigs. Transplantation
Proceedings 2007: 133: pp 21-26.
Li J, Zhang G, Holtby H, Humpl T, Caldarone CA,
Van Arsdell GS, Redington AN: Adverse effects of
dopamine on systemic hemodynamic status and
oxygen transport in neonates after the Norwood
procedure. Journal of the American College of
Cardiology 2006: 48: pp 1859-1864.
Li J, Zhang G, McCrindle BW, Holtby H, Humpl T,
Cai S, Caldarone CA, Redington AN, Van Arsdell
GS: Profiles of hemodynamics and oxygen
transport derived by using continuous measured
oxygen consumption after the Norwood procedure.
Journal of Thoracic and Cardiovascular Surgery
2007: 133: pp 441-448.
Mahadevan VS, Horlick EM, Benson LN,
McLaughlin PR: Transcatheter closure of aortic
sinus to left atrial fistula caused by erosion
of Amplatzer septal occluder. Catheterization
and Cardiovascular Interventions 2006: 68:
pp 749-753.
Maimon MS, Benson LN, Kirsh JK, Do A, Wilson
GJ, Ratnapalan S: Cardiac perforation as a late
complication of percutaneous atrial septal defect
repair using Amplatzer septal occluder. Pediatrics
2006: 118: pp 1572-1575.
Maimon MS, Ratnapalan S, Do A, Kirsh JA, Wilson
G, Benson L: Cardiac perforation six weeks after
percutaneous atrial septal defect repair using
Amplatzer septal occluder. Pediatrics 2006: 118:
pp e1572-e1575.
McDonald CM, Karamlou T, Wengle JG, Gibson J,
McCrindle BW: Nutritional environment available
for outpatient, visitors and staff of children’s
hospitals in Canada and the United States.
Archives of Pediatrics & Adolescent Medicine
2006: 160: pp 900-905.
McCrindle B, Karamlou T, Wong H, Gangam N,
Trivedi K, Lee JK, Benson L: Presentation,
management and outcomes of thrombosis for
children with dilated cardiomyopathy. Canadian
Journal of Cardiology 2006: 22: pp 685-690.
McCrindle BW: Cardiovascular consequences of
paediatric obesity: Will there be a future epidemic
of premature cardiovascular disease? Paediatrics
and Child Health 2007: 12: pp 175-177.
McCrindle BW, Urbina EM, Dennison BA,
Jacobson MS, Steinberger J, Rocchini AP, Hayman
LL, Daniels SR, from the Atherosclerosis,
Hypertension and Obesity in Youth Committee,
Council of Cardiovascular Disease in the Young,
American Heart Association: Drug therapy
of high risk lipid abnormalities in children and
adolescents. Circulation 2007: 115:
pp 1948-1967.
McCrindle BW, Urbina EM, Dennison BA, Jacobson
MS, Steinberger J, Rocchini AP, Hayman LL,
Daniels SR: Summary of the American Heart
Association’s Scientific Statement on drug therapy
of high risk lipid abnormalities in children and
adolescents. Arteriosclerosis, Thrombosis, and
Vascular Biology 2007: 27: pp 982-985.
Dr. Seema Mital and lab staff
Gross GJ, Chiu CC, Hamilton RM, Kirsh JA,
Stephenson EA: Natural history of postoperative
heart block in congenital heart disease:
Implications for pacing intervention. Heart Rhythm
2006: 3: pp 601-604.
McCrindle BW, Williams RV, Mital S, Clark BJ,
Russell JL, Klein G, Eisenmann JC: Decreased
levels of physical activity in pediatric patients
after the Fontan procedure. Archives of Disease in
Childhood 2007: 92: pp 509-514.
McLaughlin P, Benson L, Horlick E: The role of
cardiac catheterization in adult congenital
heart disease. Cardiology Clinics 2006: 24:
pp. 531-556.
Nalli N, Stewart-Teixeira L, Dipchand AI:
Amiodarone-sirolimus/tacrolimus interaction
in a pediatric heart transplant patient. Pediatric
Transplantation 2006: 10: pp 736-739.
Newburger JW, Sleeper LA, McCrindle BW, Minich
LL, Gersony W, Vetter VL, Atz AM, Li JS, Takahashi
M, Baker AL, Colan SD, Mitchell PD, Klein GL,
Sundel RP, for the Pediatric Heart Network
Investigators: Randomized trial of pulse steroid
therapy for primary treatment of Kawasaki
disease. The New England Journal of Medicine
2007: 356: pp 663-675.
Nielsen JM, Kristiansen SB, Ringgaard S, Nielsen
TT, Flyvbjerg A, Redington AN, Botker HE: Left
ventricular volume measurement in mice by
conductance catheter. Evaluation and
optimization of calibration. American Journal of
Physiology – Heart and Circulatory Physiology
March 23, 2007 [Epub ahead of print].
Nii M, Hamilton RM, Fenwick L, Kingdon JC,
Roman KS, Jaeggi ET: Assessment of fetal
atrioventricular time intervals by tissue Doppler
and pulse Doppler echocardiography: normal
values and correlation with fetal electrocardiography. Heart 2006: 92: pp1831-1837.
Nii M, Roman KS, Kingdom J, Redington AN,
Jaeggi ET: Assessment of the evolution of normal
fetal diastolic function during mid and late
gestation by spectral Doppler tissue
echocardiography. Journal of the American Society
of Echocardiography 2006: 19: pp 1431-1437.
Ozawa A, Chaturvedi R, Lee K-J, Benson LN:
Femoral vein hemostasis in children using a
suture-mediated closure device. Journal of
Interventional Cardiology 2007: 20: pp 1-5.
Peirone AR, Lee KJ, Golding IF, Marks S, Russell J,
Benson LN: Exercise performance and blood
pressure responses in children after stenting of
aortic coarctation. Progress in Pediatric Cardiology
2006: 22: pp 161-164.
Dr. Bob Hamilton
Pihkala J, Yazaki S, Metha R, Lee K-J, Chaturvedi
R, McCrindle BW, Van Arsdell G, Benson LN:
Feasibility and clinical impact of Tran catheter
closure of interatrial communications after a
fenestrated Fontan procedure: medium-term
outcomes. Catheterization and Cardiovascular
Interventions 2007: 69: pp 1007-1014.
Pollock BarZiv SM, McCrindle BW, West LJ, Edgell
D, Coles JG, Van Arsdell GS, Bohn D, Perez R,
Campbell A, Dipchand AI: Outcomes of pediatric
patients bridged to heart transplantation from
extracorporeal membrane oxygenation (ECMO)
support. American Society for Artificial Internal
Organs 2007: 53: pp 97-102.
Redington AN: Determinants and assessment of
pulmonary regurgitation in tetralogy of Fallot:
Practice and pitfalls. Cardiology Clinics 2006: 24:
pp 631-639.
Reid GJ, Webb GD, Barzel M, McCrindle BW, Irvine
MJ, Siu SC: Estimates of life expectancy by
adolescents and young adults with congenital
heart defects. Journal of the American College of
Cardiology 2006: 48: pp 349-355.
Roman KS; Fouron JC; Nii M; Smallhorn JF;
Chaturvedi RR; Jaeggi ET: Determinanats of
outcome in fetal pulmonary valve stenosis or
atresia with intact ventricular septum. American
Journal of Cardiology 2007: 99: pp 699-703.
Sarkissian T, Beyenne J, Feldman B, McCrindle
BW, Silverman ED: Longitudinal examination of
lipid profiles in pediatric systemic lupus
erythematosus. Arthritis & Rheumatism 2007: 56:
pp 631-638.
Schmidt MR, Smerup M, Konstantinov IE, Shimizu
M, Li J, Cheung M, White PA, Kristiansen SB,
Sorensen KE, Dzavik V, Redington AN, Kharbanda
RK: Intermittent peripheral tissue ischemia during
coronary ischemia reduces myocardial infarction:
Ffirst demonstration of remote ischemic
preconditioning. American Journal of Physiology –
Heart and Circulatory Physiology 2007: 292:
pp H1883-H1890.
Shimizu M, Konstantinov IE, Kharbanda RK,
Cheung MH, Redington AN: Effects of intermittent
lower limb ischaemia on coronary blood flow and
coronary resistance in pigs. Acta Physiologica
2007: 190: pp 103-109.
Sleeper LA, Anderson P, Hsu DT, Mahony L,
McCrindle BW, Roth SJ, Saul JP, Williams RV, Geva
T, Colan SD, Clark BJ: Design of a large crosssectional study to facilitate future clinical trials in
children with the Fontan palliation. American
Heart Journal 2006: 152: pp 427-433.
Stephenson EA, Kaltman JR: Current state of the
art for use of pacemakers and defibrillators in
patients with congenital cardiac malformations.
Cardiology in the Young 2006: 16: pp 151-156.
Stoica SC, Satchithananda DK, White PA,
Sharples L, Parameshwar J, Redington AN, Large
SR: Brain death leads to abnormal contractile
properties of the human donor right ventricle.
Journal of Thoracic and Cardiovascular Surgery
2006: 132: pp 116-123.
Suto F, Zhu W, Chan A, and Gross GJ: IKr and IKs
remodeling differentially affects QT interval
prolongation and dynamic adaptation to heart
rate acceleration in bradycardic rabbits. American
Journal of Physiology – Heart and Circulatory
Physiology 2007: 292: pp H1782-H1788.
Takahashi K, Guerra V, Roman KS Nii M,
Redington AN, Smallhorn JF: Three-dimensional
echocardiography improves the understanding of
the mechanisms and site of left atrioventricular
valve regurgitation in atrioventricular septal defect.
Journal of the American Society of
Echocardiography 2006: 19: pp 1502-1510.
Thavendrianathan P, Jones E, Han RK, CullenDean G, Helden E, Conner WT, McCrindle BW:
Association between physical activity, adiposity
and lipid abnormalities for children with familial
hyperlipidemia. European Journal of Cardiovascular
Prevention & Rehabilitation 2007: 14: pp 59-64.
Wald RM, Tham EB, McCrindle BW, Goff DA,
McAuliffe FM, Golding F, Jaeggi ET, Hornberger LK,
Tworetzky W, Nield LE: Outcome after prenatal
diagnosis of tricuspid atresia: A multicenter
experience. American Heart Journal.2007: 153:
pp 772-778.
Walsh MA, Lee K-J, Chaturvedi R, Van Arsdell GS,
Benson LN: Radiofrequency perforation of right
ventricular outflow tract as a palliative strategy for
pulmonary atresia with ventricular septal defect.
Catheterization and Cardiovascular Interventions
2007: 69: pp 1015-1020.
Zhou YQ, Bishay R, Feintuch A, Tao K, Golding F,
Zhu W, West LJ, Henkelman RM: Morphological
and functional evaluation of murine heterotopic
cardiac grafts using ultrasound biomicroscopy.
Ultrasound in Medicine and Biology 2007: 33:
pp 870-879.
Zhou YQ, Bishay R, Feintuch A, Tao K, Golding F,
Zhu W, West LJ, Henkelman RM: Morphological
and functional observations of murine
heterotopic cardiac isografts using ultrasound
biomicroscopy. Journal of the American
Society of Echocardiography 2006: 19: p 696.
BOOK CHAPTERS
Cheung M, Redington AR: Systolic and diastolic
dysfunction. In: Heart Failure in Children and
Young Adults: From Molecular Mechanisms to
Medical and Surgical Strategies (Chang AC,
Towbin JA, eds). Saunders Elsevier, Philadelphia,
2006.
Ilina M, Stephenson EA: Conduction defects:
Atrioventricular and bundle branch block. In:
Electrocardiograms for the Family Physician
(Yadava, OP, ed). Pushpanjali Medical Publication,
Delhi, India, 2007.
FUNDING
A randomized, double-blind, multi-center study of
antiarrhythmic medications in the treatment of
infants with Supraventricular Tachycardia (SAMIS
Trial). Sanatani S, McCrindle, BW, Stephenson E,
Potts J, Etheridge S. The Heart and Stroke
Foundation of Canada ($111,420 2006-2007;
$444,060 four years to 2010)
A transatlantic network to define the mechanisms,
mediators and clinical applications of remote
ischemic preconditioning. Redington AN, Callahan
J, Wilson G, Kharbanda R, Toftegaard Nielsen T,
Botker HE, McCrindle, BW. The Leducq Foundation
(US$6,523,095 2006-2011)
Characterization of circulating effectors and
temporal profiling of remote ischaemic
preconditioning. Redington AN, Callahan J, Gross
GJ, Kharbanda R. Canadian Institutes of Health
Research ($324,951 2006-2009)
Clinical and genomic responses to remote
ischemic preconditioning. McCrindle BW,
Redington AN, Arab S, Coles J, Holtby H, Liu P,
Schwartz S, Van Arsdell G. The National Heart
Lung and Blood Institute/National Institutes of
Health (US$432,091 2006-2007; US$2,047,004
five years to 2011)
Clinical and laboratory evaluation of acute
rejection, myocyte growth, repair and oxidative
stress following de novo cardiac transplant: A
comparison between Tacrolimus- and
Cyclosporine-based immunprophylactic regimens
with mycophenolic acid therapeutic drug
monitoring. Dipchand AI, Pollock BarZiv S, AllainRooney T, Kantor PF. Astellas Pharma Canada Inc.
($65,000 2006-2008)
Contractile and electrophysiologic adaptations to
constrained heart rate conditions. Gross GJ,
Redington AN. The Heart and Stroke Foundation
of Ontario ($209,097 2006-2008)
Contribution of 3-dimensional echocardiography
to surgery for left ventricular outflow tract
obstruction in children. Friedberg MK, Van Arsdell
G, Calderone C, Coles J, Golding F, Bradley T, and
Gooi A. The Hospital for Sick Children Paediatric
Consultants Partnership’s Grant ($9,819 20072008)
Cyclosporine C2 Monitoring in paediatric heart
transplant recipients: A pilot study. Dipchand AI,
Allain-Rooney T. Novartis Pharmaceuticals Inc.
($17,223 2006-2007)
16
DEPARTMENT OF PAEDIATRICS
Effects of remote ischemic preconditioning on the
clinical investigation and genomic responses to
open heart surgery in children. Redington AN,
McCrindle BW. Canadian Institutes of Health
Research ($100,000 2007-2008)
Optimizing heart health for children after the
fontan procedure through physical activity.
McCrindle BW, Longmuir P, Russell J. The Heart
and Stroke Foundation of Canada ($62,184
2006-2007; $119,967 two years to 2008)
Effects of right ventricular intra-ventricular
mechanical dyssynchrony on right and left
ventricular dysfunction in tetralogy of fallot.
Friedberg MK, Redington AN, Yoo S-J, Stephenson
E, Russell J, Kantor P, Roche L. National Grants
Program, The Hospital for Sick Children
($108,766 2007-2008)
Perioperative use of thymoglobulin in paediatric
heart transplant recipients. Dipchand AI, PollockBarZiv SM, Allain-Rooney T, Kantor PF. Genzyme
Canada ($5,000 2006-2007)
HLA Sensitization: Prevalence and impact of
alloantibodies in paediatric heart transplant
recipients. Dipchand AI, Pollock-Barziv S,
McCrindle BM. The Hospital for Sick Children
Paediatric Consultants Partnership’s Grant
($10,000 2007-2008)
Improving paediatric cardiac care in Ontario:
Leveraging information to enhance patient
outcomes, provide accountability and system
monitoring. Kantor PF, Syed N, MacDonald S.
Ontario Ministry of Health and Long-Term Care
($250,000 2006-2007)
Individualized heparin and protamine
management in infants undergoing
cardiopulmonary bypass for cardiac surgery
reduces bleeding and blood transfusion
requirements. Gruenwald C, McCrindle BW, Chan
A, Van Arsdell G, Holtby H. The Heart and Stroke
Foundation of Canada ($57,063 2006-2007;
$108,566 two years to 2008)
Inflammation and atherosclerosis in paediatric
rheumatic disease. Bradley TJ, Beyene J,
Schneider R, Feldman B, Silverman ED. The
Labatt Family Heart Centre – Innovation Fund
($24,000 2007-2008)
Intrauterine growth retardation associated with
and without placental insufficiency: Impact on
myocardial function and on arterial compliance.
Jaeggi ET, Bradley TJ, Keating SJ, Kingdom JCP.
The Heart and Stroke Foundation of Ontario
($77,255 2006-2008)
Late functional status in a cohort of survivors with
pulmonary atresia intact ventricular septum from
the Congenital Heart Surgeons Society Study.
McCrindle BW, Caldarone C. The Children’s Heart
Foundation (US$86,308 2006-2007;
US$89,190 2007-2008)
Molecular expression and physiology in developing
atrioventricular nodal cells. Hamilton RM, Gross
GJ, Silverman ED. Canadian Institutes of Health
Research ($370,500 2006-2009)
ANNUAL REPORT 2006-07
Pilot study of carotid intima medial thickness in
association with second trimester uterine artery
Doppler sonography. Lausman A, Bradley TJ,
Kingdom JCP, Ray J. The Physicians’ Services
Incorporated Foundation ($13,500, 2006-2007)
Role of chronic inflammation and systemic lupus
erythematosus-related factors in the development
of premature atherosclerosis in paediatric SLE.
Silverman ED, Bargman JM, Beyene J, Bradley TJ.
The Heart and Stroke Foundation of Ontario
($304,826 2006-2009)
Temporal profiling and circulating effectors of
remote ischemic preconditioning. Redington AN,
Callahan J. Canadian Institutes of Health
Research ($284,000 2005-2008)
The effect of remote ischemic preconditioning on
clinical and genetic responses to open heart
surgery in children. McCrindle BW, Redington AN.
The Canadian Institutes of Health Research
($97,360 2007-2008)
The SAMIS Trial: Multicenter study of
antiarrhythmic medications for treatment of
infants with supraventricular tachycardia.
Sanatani, S, Stephenson EA, Potts J, McCrindle
BM, Etheridge S. The Heart and Stroke
Foundation of British Columbia and Yukon
($440,060 2006-2010)
Validation of accelerometry as a measure of
physical activity and inactivity in children with
chronic disease. Feldman B, McCrindle BW,
Stephens S, Takken T, Wright V, Tremblay M,
Eslinger D, Beyene J, Walker-Schneiderman J,
Biggar W, Longmuir P, Vandernet J.
The Canadian Institutes of Health Research
($65,000 2007-2008)
Ventricular force and vascular stiffness in the
evaluation of paediatric heart failure. Kantor PF,
Bradley T (co-PI), Roche SL, Slorach C. The
Hospital for Sick Children Paediatric Consultants
Partnership’s Grant ($9,100 1997)
Ventricular repolarization in bradycardic electrical
remodeling. Gross GJ. The Heart and Stroke
Foundation of Ontario ($268,447 2007-2010)
Ventricular repolarization in complete heart block.
Gross GJ. The Heart and Stroke Foundation of
Ontario ($208,406 2004-2007)
Dr. Lee Benson
Vogel M, Redington AN: Assessment of contractile
function by Doppler myocardial imaging:
isovolumic versus ejection phase indices. In:
Doppler Myocardial Imaging (Sutherland GR,
Hatle L, Claus P, D’hooge J, Bijnens BH, eds).
BSWK, Hasselt, Belgium, 2006.
Division Head
Dr. Rosanna Weksberg
Dr. Stephen Meyn
Dr. Ahmad Teebi
Full-Time
Dr. David Chitayat
Dr. Joe Clarke
Dr. Annette Feigenbaum
Part-Time
Dr. Alan Berzen
Dr. Karen Chong
Dr. Leona Fishman
Dr. Chumei Li
Clinical Fellows
Dr. Gustavo Maegawa
Dr. Marianne Rohrbach
Dr. David Skidmore
Dr. Hanna Faghfoury
Dr. Sharan Goobie
Dr. Linda Kim
Dr. Lynette Penney
Residents
Dr. Fathiya Al-Murshedi
Dr. Tawfeg Ben-Omran
MSc Students
Martha Balicki
Mireille Cloutier
Miranda Galvin
Seema Jamal
Laura Palma
Christina Paradiso
Sari Zelenietz
Administrative Staff
Michael Delaney
Susan Dukhedin-Lalla
Jennifer Ewing
Delizia Ferri
Laurie Furtado
Sandy Maksimowska
Hamali Maru
Ardian Shtylla
Rozmin Visrama
Clinical and Metabolic Genetics
DIVISIONAL OVERVIEW
The Division of Clinical and Metabolic Genetics is recognized
nationally and internationally for its contributions to clinical
genetics, genetics research and education.
One recent example of such leadership included the convening
of key individuals from across the province for a retreat
aimed at integrating negotiations with the Ontario Ministry of
Health for resourcing clinical and laboratory genetic services.
This highly successful provincial retreat was sponsored
by the Department of Paediatrics and a second meeting is
planned for 2008.
New initiatives include the establishment of the DNA Resource
Centre dedicated to facilitating genetic testing that is not
available at SickKids. The DNA Resource Centre provides up-todate information regarding genetic testing available nationally
and internationally, ensuring that all patients at SickKids have
access to cutting-edge clinical and research testing options.
Expansion of provincial newborn screening has led to the
development of an independent Newborn Screening Program
which is staffed by two nurses, a genetic counsellor, a dietician,
a social worker, an information coordinator and a metabolic
geneticist. The Newborn Screening Program involves multiple
subspecialties at SickKids, including Genetics, Endocrinology,
Haematology and Respirology.
Research endeavours in the Division are a vital part of our program
and currently focus on the translation of new genomic information
for patients and family members. A rapid increase in the use of
microarrays for genetic testing has expanded the need for clinical
evaluation of new data being generated so that appropriate and
relevant information can be provided to patients and their families.
There were two awards for the Sixth Annual Starbucks Clinical
Research Summer Students Competition. The recipients were
Katie Marchington for a study on autism and epigenetics and
Margarita Kaliazina for a study of the resources required to
transition paediatric genetic metabolic patients to adult hospitals.
The Division of Clinical and Metabolic Genetics has developed
and participated in numerous educational activities for different
training programs within the hospital. The Division provides
excellent teaching opportunities with important links to the
Research Institute and the Department of Laboratory Medicine.
The Division directs Fellowship and Residency training programs
in genetic medicine as well as the MSc Program in Genetic
Counselling which was reaccredited this past year by the Ontario
Council of Graduate Studies.
Dr. Andreas Schulze
The reorganization of the Neurofibromatosis type1 and
Skeletal Dysplasia Clinics highlight the Division’s commitment
to enhance patient services through interdisciplinary care.
The recent establishment of the Neurogenetics Clinic also
demonstrates our focus on providing excellent genetic care
to our patients and their families.
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
19
Al-Hassnan ZN, Teebi AS: Craniofacial anomalies,
humero-radial synostosis, rhizomelic limb
shortness: Previously unrecognized autosomal
recessive syndrome. American Journal of Medical
Genetics 2007: 143: pp 521-5277.
Alkazaleh F, Chaddha V, Viero S, Malik A,
Anastasiades C, Sroka H, Chitayat D, Toi A,
Windrim RC, Kingdom JC: Second-trimester
prediction of severe placental complications in
women with combined elevations in alphafetoprotein and human chorionic gonadotrophin.
American Journal of Obstetrics and Gynecology
2006: 194: pp 821-827.
Bader R, Hornberg LK, Nijmeh LJ, Al-Kazaleh F,
Ryan G, Toi A, Viero S, Butany J, Chitayat D:
Fetal pericardial teratoma: Presentation of two
cases and review of literature. American Journal
of Perinatology 2006: 23: pp 53-58.
Bassett A, Caluseriu O, Weksberg R, Young D,
Chow E: Catechol-O-methyl transferase and
expression of schizophrenia in 73 adults with
22q11 Deletion Syndrom. Biological Psychiatry
2007: 61: pp 1135-1140.
Beatty L, Weksberg R, Sadowski P: Detailed
analysis of the methylation patterns of the
KvDMR1 imprinting control region of human
chromosome 11. Genomics 2006: 87: pp 46-56.
Ben-Neriah Z, Withers S, Thomas M, Toi A,
Chong K, Pai A, Velscher L, Vero S, Keating S,
Taylor G, Chitayat D: OEIS complex: Prenatal
ultrasound and autopsy findings. Ultrasound in
Obstetrics and Gynecology 2007: 29: pp 170-177.
Ben-Omran T, Wong H, Blaser S, Feigenbaum A:
Late-onset Cobalamin-C disorder: Challenging
diagnosis. American Journal of Medical Genetics
(Part A) 2007: 143: pp 979-984.
Blaser S, Propst E, James A, Feigenbaum A,
Martin D, Shannon P, Papsin B: Inner ear
dysplasia is common in children with Down
syndrome (trisomy 21). Laryngoscope 2006:
116: pp 2113-2119.
20
DEPARTMENT OF PAEDIATRICS
Cameron JM, Levandovskiy V, MacKay N, Raiman
J, Clarke JTR, Feigenbaum A, Elpeleg O, Robinson
BH: Novel mutations in lipoamide dehydrogenase
deficiency in two cousins with borderline-normal
PDH complex activity. American Journal of Medical
Genetics 2006: 140: pp 1542-1552.
Tolmie JL, Tomlin P, Voit T, Weschke B, Woods CG,
Lebon P, Bonthron DT, Ponting CP, Jackson AP:
Mutations in genes encoding ribonuclease H2
subunits cause Aicardi-Goutieres syndrome and
mimic congenital viral brain infection. Nature
Genetics 2006: 38: pp 910-916.
Cameron JM, Levandovskiy V, MacKay N, Raiman
J, Renaud DL, Clarke JTR, Feigenbaum A, Elpeleg
O, Robinson BH: Novel mutations in lipoamide
dehydrogenase deficiency in two cousins with
borderline-normal PDH complex activity. American
Journal of Medical Genetics 2006: 140: p 14.
Feigenbaum A, Doherty E, Bai R, Kwon H, Tan D,
Sloane A, Robinson B, Wong LJ: Novel
mitochondrial DNA mutations associated with
myopathy, cardiomyopathy, renal failure and
deafness. American Journal of Medical Genetics
2006: 140: pp 2216-2222.
Castagna A, Addis J, McInnes RR, Clarke JTR,
Ashby P, Blaser S, Robinson BH: Late onset Leigh
syndrome and ataxia due to a T to C mutation
at bp 9,185 of mitochondrial DNA. American
Journal of Medical Genetics (Part A) 2007: 143:
pp 808-816.
Ferrentino R, Bassi MT, Chitayat D, Tabolacci E,
Meroni G: MID1 mutation screening in a large
cohort of Opitz G/BBB syndrome patients: Twentynine novel mutations identified. Human Genetics
2007: 28: pp 206-207.
Chitayat D, Sroka H, Keating S, Colby RS, Ryan G,
Toi A, Blaser S, Viero S, Devisme L, BouteBenejean O, Manouvrier-Hanu S, Mortier G, Loeys
B, Rauch A, Bitoun P: The PDAC syndrome
(pulmonary hypoplasia/agenesis, diaphragmatic
hernia/eventration, anophthalmia/microphthalmia,
and cardiac defect) (Spear syndrome, MatthewWood syndrome): Report of eight cases
including a living child and further evidence for
autosomal recessive inheritance. American
Journal of Medical Genetics (Part A) 2007: 143:
pp 1268-1281.
Chitayat D: First trimester ultrasound diagnosis
of lethal multiple pterygium syndrome. Fetal
Diagnosis and Therapy 2006: 21: pp 466-470.
Clarke JTR: Fabry disease. Annals of Internal
Medicine 2007: 146: pp 425-433.
Crow YJ, Leitch A, Hayward BE, Garner A, Parmar
R, Griffith E, Ali M, Semple C, Aicardi J, Babul-Hirji
R, Baumann C, Baxter P, Bertini E, Chandler KE,
Chitayat D, Cau D, Dery C, Fazzi E, Goizet C, King
MD, Klepper J, Lacombe D, Lanzi G, Lyall H,
Martinez-Frias ML, Mathieu M, McKeown C,
Monier A, Oade Y, Quarrell OW, Rittey CD, Rogers
RC, Sanchis A, Stephenson JB, Tacke U, Till M,
ANNUAL REPORT 2006-07
Fluss J, Blaser S, Chitayat D, Akoury H, Glanc P,
Skidmore M, Raybaud C: Molar tooth sign in fetal
brain magnetic resonance imaging leading to
the prenatal diagnosis of Joubert syndrome and
related disorders. Journal of Child Neurology
2006: 21: pp 320-324.
Georgiou DM, Nicolaou P, Chitayat D, Koutsou P,
Babul-Hirji R, Vajsar J, Murphy J, Christodoulou K:
A novel GDAP1 mutation 439delA is associated
with autosomal recessive CMT disease. The
Canadian Journal of Neurological Sciences 2006:
33: pp 311-316.
Ghai S, Fong KW, Toi A, Chitayat D, Pantazi S,
Blaser S: Prenatal US and MR Imaging Findings
of Lissencephaly: Review of fetal cerebral
sulcal development. Radiographics 2006: 26:
pp 389-405.
Gibas AL, Klatt R, Johnson J, Clarke JTR, Katz J:
Pain in males and females with Fabry disease:
A pilot study of the pain experienced by males
and females with Fabry disease. Pain Research
and Management 2006: 11: pp 185-192.
Dr. Julian Raiman
PUBLICATIONS
Girirajan S, Mendoza-Londono R, Vlangos CN,
Dupuis L, Nowak NJ, Bunyan DJ, Hatchwell E,
Elsea SH: Smith-Magenis syndrome and
moyamoya disease in a patient with del(17)
(p11.2p13.1). American Journal of Medical
Genetics 2007: 143: pp 999-1008.
Gissen P, Tee L, Johnson CA, Genin E, Caliebe A,
Chitayat D, Clericuzio C, Denecke J, Di Rocco M,
Fischler B, Fitzpatrick D, Garcia-Cazorla A, Guyot
D, Jacquemont S, Koletzko S, Leheup B, Mandel
H, Sanseverino MT, Houwen RH, McKiernan PJ,
Kelly DA, Maher ER: Clinical and molecular
genetic features of ARC syndrome. Human
Genetics 2006: 120: pp 396-409.
Glanc P, Umranikar S, Koff D, Tomlinson G,
Chitayat D: Fetal sex assignment by sonographic
evaluation of the pelvic organs in the second
and third trimesters of pregnancy. Journal of
Ultrasound in Medicine 2007: 26: pp 563-569.
Gundogan M, Fong K, Keating S, Pierre-Louis J,
Chitayat D: First trimester ultrasound diagnosis
of lethal multiple pterygium syndrome. Fetal
Diagnosis and Therapy 2006: 21: pp 466-470.
Hamamy HA, Teebi AS, Oudjhane K, Shegem NN,
Ajlouni KM: Severe hypertelorism, midface
prominence, prominent/simple ears, severe
myopia, borderline intelligence, and bone fragility
in two brothers: New syndrome? American Journal
of Medical Genetics 2007: 143: pp 229-234.
Kolomietz E, Ben-Omran T, Chitayat D, Mah M:
Array-based genomic delineation of a familial
duplication 11q14.1-q22.1 associated with
recurrent depression. American Journal of Medical
Genetics 2006: 141: pp. 214-219.
Koren G, Cairns J, Chitayat D, Gaedigk A, Leeder
SJ: Pharmacogenetics of morphine poisoning
in a breastfed neonate of a codeine-prescribed
mother. Lancet 2006: 368: p 704.
Lenane P, Cammisuli S, Chitayat D, Krafchik B:
What syndrome is this? KID syndrome (keratitis,
ichthyosis, deafness). Pediatric Dermatology
2006: 23: pp 81-83.
Maegawa G, Chitayat D, Blaser S, Whyte H,
Thomas M, Kim P, Kim J , Taylor G, McNamara PJ:
Duodenal and biliary atresia associated with
facial, thyroid and auditory apparatus
abnormalities. A new mandibulofacial dysostosis
syndrome? Journal of Clinical Dysmorphology
2006: 15: pp 191-196.
Maegawa GHB, Stockley T, Tropak M, Banwell B,
Blaser S, Kok F, Giugliani R, Mahuran D, Clarke
JTR: The natural history of juvenile or subacute
GM2 gangliosidosis-21 new cases and literature
review of 134 previously reported. Pediatrics
2006: 118: pp e1550-e1562.
Maegawa GHB, Tropak M, Butner J, Stockley T,
Kok F, Clarke JTR, Mahuran DJ: Pyrimethamine as
a potential pharmacological chaperone for lateonset forms of GM2 gangliosidosis. Journal of
Biological Chemistry 2007: 282: pp 9150-9161.
Mahant S, Feigenbaum A: A child with an
underrecognized form of metal delay: A congenital
disorder of glycosylation. Canadian Medical
Association Journal 2006: 175: pp 1369.
Mallory SB, Krafchik BR, Lenane P, Cammisuli S,
Chitayat D: What syndrome is this? Pediatric
Dermatology 2006: 23: pp 81-83.
Milic A, Blaser S, Robinson A, Viero S, Halliday W,
Winsor E, Toi A, Thomas M, Chitayat D: Prenatal
detection of microtia by MRI in a fetus with
trisomy 22. Pediatric Radiology 2006: 36:
pp 706-710.
Pastores GM, Arn P, Beck M, Clarke JTR, Guffon N,
Kaplan P, Muenzer J, Norato DY, Shapiro E,
Thomas J, Viskochil D, Wraith JE: The MPS I
registry-design, methodology, and early findings of
a global disease registry for monitoring patients
with Mucopolysaccharidosis Type I. Molecular
Genetics and Metabolism 2007: 91: pp 37-47.
Scaglia F, Hsu CH, Kwon H, Bai RK, Perng CL,
Dai P, Chang HM, O’Brian Smith E, Whiteman
DAH, Feigenbaum A, Gropman A, Wong LJC:
Molecular bases of hearing loss in multisystemic
mitochondrial cytopathy. Genetics in Medicine
2006: 8: pp 641-652.
Seifert W, Holder-Espinasse M, Spranger S,
Hoeltzenbein M, Rossier E, Dollfus H, Lacombe D,
Verloes A, Chrzanowska KH, Maegawa GH, Chitayat
D, Kotzot D, Huhle D, Meinecke P, Albrecht B,
Mathijssen I, Leheup B, Raile K, Hennies HC, Horn
D: Mutational spectrum of COH1 and clinical
heterogeneity in Cohen syndrome. Journal of
Medical Genetics 2006: 43: p e22.
Shah PS, Siriwardena K, Taylor G, Steele L, Ray P,
Blaser S, Chitayat D: Sudden infant death in a patient
with FGFR3 P250R mutation. American Journal
of Medicinal Genetics 2006: 140: pp 2794-2796.
Shah PS, Weksberg R, Chitayat D: Overgrowth
with severe developmental delay following
IVF/ICSI: A newly recognized syndrome?
American Journal of Medical Genetics 2006:
140: pp 1312-1315.
Pasutto F, Sticht H, Hammersen G, GillessenKaesbach G, Fitzpatrick DR, Nurnberg G, Brasch F,
Schirmer-Zimmermann H, Tolmie JL, Chitayat D,
Houge G, Fernandez-Martinez L, Keating S, Mortier
G, Hennekam RC, von der Wense A, Slavotinek A,
Meinecke P, Bitoun P, Becker C, Nurnberg P, Reis
A, Rauch A: Mutations in STRA6 Cause a broad
spectrum of malformations including anophthalmia,
congenital heart defects, diaphragmatic hernia,
alveolar capillary dysplasia, lung hypoplasia, and
mental retardation. American Journal of Human
Genetics 2007: 80: pp 550-560.
Shuman C, Smith AC, Steele L, Ray PN, Clericuzio C,
Zackai E, Parisi MA, Meadows AT, Kelly T, Tichauer D,
Squire JA, Sadowski P, Weksberg R: Constitutional
UPD for Chromosome 11p15 in individuals with
isolated hemihyperplasia is associated with high
tumor risk and occurs following assisted
reproductive technologies. American Journal of
Medical Genetics 2006: 140: pp 1497-1503.
Patel MS, Becker LE, Toi A, Armstrong DL,
Chitayat D: Severe, fetal-onset form of
olivopontocerebellar hypoplasia in three sibs:
PCH type 5? American Journal of Medical
Genetics 2006: 140: pp 594-603.
Simchen MJ, Toi A, Silver M, Smith CR, Hornberger
LK, Taylor G, Chitayat D: Fetal cardiac calcifications:
Report of four prenatally diagnosed cases and
review of the literature. Ultrasound in Obstetrics
and Gynecology 2006: 27: pp 325-330.
Potocki L, Bi W, Treadwell-Deering D, Carvalho
CM, Eifert A, Friedman EM, Glaze D, Krull K, Lee
JA, Lewis RA, Mendoza-Londono R, RobbinsFurman P, Shaw C, Shi X, Weissenberger G,
Withers M, Yatsenko SA, Zackai EH, Stankiewicz P,
Lupski JR: Characterization of Potocki-Lupski
syndrome (dup(17)(p11.2p11.2)) and delineation
of a dosage-sensitive critical interval that can
convey an autism phenotype. American Journal of
Human Genetics 2007: 80: pp 633-649.
Sirrs SM, Clarke JTR: Agalsidase alfa therapy for
Fabry disease. Expert Review of Endocrinology
and Metabolism 2007: 2: pp 147-154.
Ries M, Clarke JTR, Whybra C, Timmons M,
Robinson C, Schlaggar BL, Pastores G, Lien YH,
Kampmann C, Brady RO, Beck M, Schiffmann R:
Enzyme replacement therapy with agalsidase alfa
in children with Fabry disease. Pediatrics 2006:
118: pp 924-932.
Rohrbach M, Chitayat D, Drake J, Velsher L,
Sirkin WL, Blaser S: Prenatal diagnosis of fetal
exencephaly associated with amniotic band
sequence at 17 weeks of gestation by fetal
magnetic resonance imaging. Fetal Diagnosis and
Therapy 2006: 22: pp 112-115.
Smith AC, Choufani S, Ferreira JC, Weksberg R:
Growth regulation, imprinted genes and
Chromosome 11p15.5. Annual Review Pediatrics
Research 2007: 61: pp 43R-47R.
Smith AC, Rubin T, Shuman C, Estabrooks L,
Aylsworth AS, McDonald MT, Steele L, Ray PN,
Weksberg R: New chromosome 11p15
epigenotypes identified in male monozygotic twins
with Beckwith-Wiedemann syndrome. Cytogenetic
and Genome Research 2006: 113: pp 313-317.
Umranikar S, Glanc P, Unger S, Keating S, Fong K,
Trevors CD, Myles-Reid D, Chitayat D: X-Linked
dominant chondrodysplasia punctata:
Prenatal diagnosis and autopsy findings. Prenatal
Diagnosis 2006: 26: pp 1235-1240.
Vincent J, Horike S, Choufani S, Paterson A,
Roberts W, Szatmari P, Weksberg R, Fernandez B,
Scherer S: An inversion inv (4) (p12-p15.3) in
autistic sibling implicates the 4p GABA receptor
gene cluster. American Journal of Medical
Genetics 2006: 43: pp 429-434.
Weksberg R, Shuman C, Wilkins-Haug L, Mann M,
Stewart D, Croughan M, Rakowsky C, Leader A,
Hall J, Friedman JM, Simpson JL, Holmes L, InfanteRivard C: Workshop report: Evaluation of genetic
and epigenetic risks associated with assisted
reproductive technologies and infertility. Elsevier
Journal of Fertility and Sterility 2007: 88: pp 27-31.
Weksberg, R, Stachon AC, Squire JA, Moldovan L,
Bayani J, Meyn MS, Chow E, Bassett AS: Molecular
characterization of deletion breakpoints in adults
with 22q11 deletion syndrome. Human Genetics
2007: 120: pp 837-845.
Yoon G, Kramer J. Zanko A, Guzijan M. Lin S, FosterBarber A, Boxer AL: Speech and language delay
are early manifestations of Juvenile-Onset Huntington Disease. Neurology 2006: 67: pp 1265-1267.
Yoon G, Oberoi S, Tristani-Firouzi M, Etheridge SP,
Quitania L, Kramer JH, Miller BL, Fu YH, PtГЎcek LJ:
Andersen-Tawil Syndrome. Prospective cohort
analysis and expansion of the phenotype. American
Journal of Medical Genetics 2006: 140: pp 312-321.
Yoon G, Quitania L, Kramer JH, Fu YH, Miller BL,
PtГЎcek LJ: Andersen-Tawil Syndrome. Definition of
a neurocognitive phenotype. Neurology 2006: 66:
pp 1703-1710.
Zampino G, Pantaleoni F, Carta C, Cobellis G, Vasta
I, Neri C, Pogna E, De Feo E, Delogu A, Sarkozy A,
Atzeri F, Selicorni A, Rauen K, Cytrynbaum C,
Weksberg R, Dallapiccola B, Ballabio A, Gelb B,
Neri G, Tartaglia M: Diversity, parental germline
origin, and phenotypic spectrum of de nova HRAS
missense changes in Costello syndrome. Human
Mutation 2007: 28: pp 265-272.
BOOKS AND BOOK CHAPTERS
Chitayat D, Babul-Hirji R: Preconceptional genetic
counselling. In: Preventive Genetics (Gogate S,
ed). Jaypee, New Delhi, India, 2006.
MacRae AR, Chitayat D: Prenatal screening. In:
Genetic Testing, Care, Consent, and Liability
(Shart NF, Carter RF, Wiley-Liss, eds). Hoboken,
New Jersey, USA.
Chitayat D, Hall JG: Genetic aspects of twinning.
In: Multiple Pregnancies (Kilby M, Baker P,
Critchley H, Field D, eds). RCOG Press, London,
England, 2006.
Chitayat D, Koren G: Fetal malformations
associated with drugs and chemicals:
Visualization by sonography. Fetal MRI. In:
Medication Safety in Pregnancy and Breastfeeding
(Koren G, ed). McGraw-Hill, New York, 2007.
Blau N, Hoffmann GF, Leonard J, Clarke JTR:
Physician’s Guide to the Treatment and
Follow-up of Metabolic diseases. Springer-Verlag,
Berlin, 2006.
Hoffmann GF, Clarke JTR, Leonard J: The management of metabolic emergencies. In: Physician’s
Guide to the Treatment and Follow-up of Metabolic
Diseases (Blau N, Hoffmann GF, Leonard J, Clarke
JTR eds). Springer-Verlag, Berlin, 2006.
Wraith JE, Clarke JTR: The mucopolysaccharidoses.
In: Physician’s Guide to the Treatment and Followup of Metabolic Diseases (Blau N, Hoffmann GF,
Leonard J, Clarke JTR eds). Springer-Verlag,
Berlin, 2006.
Phase III clinical trial of Coenzyme Q10 in
mitochondrial disease. Multi-center double blind
placebo controlled randomized crossover trial.
Feigenbaum A. National Institutes of Health –
Office of Rare Diseases (US$154,000 2007)
Clarke JTR. Other storage disorders. In: Physician’s
Guide to the Treatment and Follow-up of Metabolic
Diseases (Blau N, Hoffmann GF, Leonard J, Clarke
JTR eds). Springer-Verlag, Berlin, 2006.
Stacpoole P, Feigenbaum A, Robinson B. National
Institutes of Health, Department of Health and
Human Services, Office of Orphan Products
Development ($1,000,000 2006-2009)
Clarke JTR. A clinical guide to inherited metabolic
diseases. 3rd Edition. Cambridge University Press,
Cambridge, 2006.
PKU 006: Multidose trial of Phenoptin in PKU.
Study approved and funded but closed by
sponsor before enrollment. Feigenbaum A.
Biomarin Pharmaceuticals ($16,485 2006)
Mendoza-Londono R, Lee B: Cleidocranial
dysplasia. In: GeneReviews at GeneTests: Medical
Genetics Information Resource [database online].
Copyright, University of Washington, Seattle,
www.genetests.org, 2006.
Baskin B, Teebi AS: Cherubism. In: Gene Reviews
at Gene Tests: Medical Genetics Information
Resource [database online]. Copyright, University
of Washington, Seattle, www.genetests.org, 2007.
Teebi AS, Kennedy S, Chitayat D, Teshima I,
Unger S, Babul-Hirji R, Shuman C, Weksberg R:
Clinical genetics. In: Hospital for Sick Children
Atlas of Paediatrics (Laxer R, Lee Ford Jones E,
Friedman J, Gerstle T, eds). Current Medicine LLC,
Philadelphia, 2006.
Weksberg R, Sadowski P, Smith AC, Tycko B:
Epigenetics. In: Emery & Rimoin’s Principles and
Practice of Medical Genetics (Rimoin DL, Connor
M, Pyeritz RE, Korf BR, eds). Churchill Livingstone,
5th Edition, Toronto, 2006.
Geschwind MD, Yoon G, Goldman J: Adult-onset
genetic disorders involving the frontal lobes.
In: The Human Frontal Lobes, Functions and
Disorders (Miller BL and Cummings JL, ed).
Guilford Publications Inc, New York, 2006.
FUNDING
Canadian Molecular Cytogenetics Platform.
Friedman JM, Chitayat D: Canadian Foundation
for Innovation ($4,512,925 2005-2010)
Rare diseases clinical research centre for
urea cycle disorders. Clarke JTR, Feigenbaum A.
Canadian Institutes of Health Research
($25,000 2006)
Canadian Fabry disease initiative. Clarke JTR,
multiple co-investigators across Canada.
Canadian Institutes of Health Research
($1,200,000 2006)
PKU 08: Phenoptin in PKU. Open label extension
study. Feigenbaum A. Biomarin Pharmaceuticals
($25,500 2006-2009)
Dynamics of human double-strand break repair.
Meyn MS. Canadian Institutes of Health Research
($123,000 2004-2008)
Canadian Molecular Cytogenetics Platform.
Meyn MS. Canadian Foundation for Innovation
($4,800,000 2004-2009)
Collaborative graduate training for program
in molecular medicine. Meyn MS. Canadian
Institutes of Health Research ($300,000
2002-2008)
The National Genetic and Birth Defects Registry.
Teebi AS. Prince Salman Institute for Handicap,
Saudi Arabia ($750,000 2003-2008)
Canadian Molecular Cytogenetic Platform.
Friedman J, Weksberg R. Canadian Foundation for
Innovation ($4,512,925 2004-2008)
Integrative genomics for health research.
Scherer S, Weksberg R. Canadian Foundation for
Innovation ($3,600,262 2004-2008)
Analysis of imprinting control in a tumour
predisposing region on human chromosome
11p15. Weksberg R, Squire J. Canadian Institutes
of Health Research ($359,565 2004-2007)
Potential predictor of schizophrenia in a genetic
high risk sample. Ontario project. Chow E, Bassett
A, Weksberg R, Zipursky R, Mikulis D. Ontario
Mental Health Foundation (Bill Jefferies
Schizophrenia Endowment Fund) ($148,188
2002-2008)
Gene expression of neuronal progenitors in a
1q22-linked familial subtype of schizophrenia.
McCurdy R, Weksberg R. Canadian Psychiatric
Research Foundation ($80,000 2005-2007)
Hunter Outcome Survey (HOS). Clarke JTR.
TKT/Shire ($16,000 2006)
Computer assisted teaching software project.
Clarke JTR, Al-Jasmi F. TKT/Shire ($60,000 2006)
Autism: Searching for epigenetics errors.
Weksberg R. SickKids Foundation New Ideas
Grant ($50,000 2007-2008)
Phenoptin in PKU PKU 004. Phase III multi-center
open label variable dose clinical trial.
Feigenbaum A. Biomarin Pharmaceuticals
($41,000 2006-2007)
Pregnancy and development outcomes. Weksberg
R, Goobie S, Kim L, Roberts W, Croughan M.
The Physicians’ Services Incorporated Foundation
($20,000 2007-2008)
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
23
Clinical Pharmacology and Toxicology
DIVISIONAL OVERVIEW
The division is one of the two major training sites of the
Royal College-accredited Clinical Pharmacology Residency
program of the University of Toronto. Our medical residency
training program spearheaded the recent change of the specialty
residency training structure to add Emergency Medicine to
the existing four entry disciplines, which include Paediatrics.
This change enables us to train residents with emergency
medicine background in the clinical toxicology stream of our
education program.
Our research programs focus on drug metabolizing enzymes
and their regulation, drug transporters, placental and mammary
gland drug transport and metabolism, and reproductive
toxicology and teratology, including fetal alcohol syndrome
research. The breadth and depth of these research programs
are shown in the publication and funding records.
In 2006 Dr. Anna Taddio received the Piafsky Young Investigator
Award and Dr. Gideon Koren received the Education Award at the
Canadian Society of Clinical Pharmacology.
Dr. Shinya Ito
The Division of Clinical Pharmacology and Toxicology focuses on
a wide range of drug-related issues in paediatrics. The division
is one of the largest and the most active paediatric
pharmacology programs internationally. Our major clinical
activities include a consultation service, the Motherisk Program,
the Ontario Regional Poison Information Centre, and DART
(Drug Allergy, Reactions and Toxicity) clinic, collaborating with the
Division of Allergy and Immunology to provide specialized outpatient follow-up and management for those with various
drug/toxin-related problems. The two toxicology information
centres annually receive about 35,000 (Motherisk) and 75,000
(Poison Information Centre) inquiries, which have reached the
limit of the response capacity of the systems. The Motherisk
Program directed by Dr. Gideon Koren continues disseminating
new knowledge in the field of drug safety for fetus and
breastfeeding babies. The Ontario Regional Poison Information
Centre led by Dr. Margaret Thompson has now become a hub for
medical toxicology training, attracting many residents and fellows
nationally and internationally. The Palliative and Bereavement
Care Service directed by Dr. Christine Newman has recently
joined the division that provides expertise specifically on drug
therapy for terminally ill patients.
24
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
Division Head
Dr. Shinya Ito
Scientific Staff
Dr. Patricia Harper
Full-Time
Dr. Gideon Koren
Dr. Christine Newman
Dr. Irena Nulman
Dr. Margaret Thompson
Cross-Appointees/
Clinical
Dr. Sylvain Baruchel
Dr. Ran Goldman
Dr. Sheila Jacobson
Dr. Prashant Joshi
Dr. Christopher Parshuram
Part-Time
Dr. David Juurlink
Dr. Denis Scolnik
Dr. Neil Shear
Dr. Marco Sivilotti
Cross-Appointees/
Scientific
Dr. Lidia Derewlany
Dr. Tom Einarson
Dr. Anna Taddio
Dr. Bonnie Stevens
Clinical Fellows
Dr. Radinka Boskovic
Dr. Saskia de-Wildt
Dr. Tali Finkelstein
Dr. Yaron Finkelstein
Dr. Facundo
Garcia Bournissen
Dr. Miho Inoue
Dr. Dan Rhodes
Dr. Arthur Staroselsky
Dr. Nobuko Taguchi
Dr. Toshihiro Tanaka
Dr. Parvaneh
Yazdanibrojeni
Residents
Dr. Lisa Thurgur
(Emergency Medicine,
Clinical Pharmacology)
Research Fellows
Dr. Alejandro A.
Nava-Ocampo
Dr. Shin-ichiro Takahashi
Administrative Staff
Ms. Niki Balamatsis
Ms. Sarah Bondy
Ms. Hila Halshtok
Ms. Leah Moscato
Ms. Donna Tedesco
Research Associate
Katarina Aleksa
HONOURS AND AWARDS
Koren G: Canadian Society for Clinical
Pharmacology, Education Award, 2006.
Koren G: Spirit of the Community Humanitarian
Award, 2007.
Taddio A: Piafsky Young Investigators Award,
2006.
PUBLICATIONS
Ahn E, Pairaudeau N, Pairaudeau N Jr, Cerat Y,
Couturier B, Fortier A, Paradis E, Koren G: A
randomized cross over trial of tolerability and
compliance of a micronutrient supplement with
low iron separated from calcium vs high iron
combined with calcium in pregnant women.
BioMed Central Pregnancy Childbirth 2006:
6: p 10.
Aleksa K, Ito S, Koren G: Enantioselective
metabolism of ifosfamide by the kidney. Chirality
2006: 18: pp 398-405.
Avner M, Henning P, Koren G, Nulman I: Validation
of the facial photographic method in fetal alcohol
spectrum disorder screening and diagnosis.
Journal of Fetal Alcohol Syndrome International
2006: 4: p e20.
Cohen-Kerem R, Nulman I, Abramow-Newerly M,
Medina D, Mazel R, Brent RL, Koren G: Diagnostic
radiation in pregnancy: Perception versus true
risks. Journal of Obstetrics and Gynecology 2006:
28: pp 43-48.
Cohen-Kerem R, Ratnapalan S, Djulus J, Duan X,
Chandra RV, Ito S: The attitude of physicians
towards cold remedies for upper respiratory
infection in infants and children: A questionnaire
survey. Clinical Pediatrics 2006: 45: pp 828-834.
Dugoua JJ, Seely D, Perri D, Koren G, Mills E:
Safety and efficacy of black cohosh (Cimicifuga
racemosa) during pregnancy and lactation.
Canadian Journal of Clinical Pharmacology 2006:
13: pp e257-e261.
Dugoua JJ, Mills E, Perri D, Koren G: Safety and
efficacy of St. John’s wort (hypericum) during
pregnancy and lactation. Canadian Journal of
Clinical Pharmacology 2006: 13: pp e268-e276.
Dugoua JJ, Mills E, Perri D, Koren G: Safety and
efficacy of ginkgo (Ginkgo biloba) during
pregnancy and lactation. Canadian Journal of
Clinical Pharmacology 2006: 13: pp e277-e284.
Einarson A, Koren G: Defective alleles may not
have contributed to adverse effects. Therapeutic
Drug Monitoring 2006: 28: pp 142-143.
Einarson A, Koren G: A survey of women’s
attitudes concerning healthy lifestyle changes
prior to pregnancy. Journal of Fetal Alcohol
Syndrome International 2006: 4: p e2.
Kozer E, Scolnik D, Jarvis AD, Koren G: The effect
of detection approaches on the reported
incidence of tenfold errors. Drug Safety 2006: 29:
pp 169-174.
Garcia-Bournissen F, Shrim A, Koren G: Safety of
gadolinium during pregnancy. Canadian Family
Physician 2006: 52: pp 309-310.
Kraemer J, Klein J, Lubetsky A, Koren G: Perfusion
studies of glyburide transfer across the human
placenta: Implications for fetal safety. The
American Journal of Obstetrics and Gynecology
2006: 195: pp 270-274.
Gareri J, Klein J, Koren G: Drugs of abuse testing
in meconium. Clinical Chima Acta 2006: 366:
pp 101-111.
Gedeon C, Behravan J, Koren G, Piquette-Miller M:
Transport of glyburide by placental ABC
transporters: Implications in fetal drug exposure.
Placenta 2006: 27: pp 1096-1102.
Houghton LA, Sherwood KL, Pawlosky R, Ito S,
O’Connor DL. [6S]-5-Methyltetrahydrofolate is
at least as effective as folic acid in preventing a
decline in blood folate concentrations during
lactation. American Journal of Clinical Nutrition
2006: 83: pp 842-850.
Koren G: A new indication for therapeutic drug
monitoring in the neonate. Therapeutic Drug
Monitoring 2006: 28: p 1.
Koren G: Paul Lemoine, French pioneer in FAS
research dies. Journal of Fetal Alcohol Syndrome
International 2006: 4: p e6.
Koren G, Florescu A, Costei AM, Boskovic R,
Moretti ME: Nonsteroidal anti-inflammatory drugs
during third trimester and the risk of premature
closure of the ductus arteriosus: a meta-analysis.
Annals of Pharmacotherapy 2006: 40:
pp 824-829.
Koren G, Gilbert C, Valois M: Metformin use
during the first trimester of pregnancy. Is it safe?
Canadian Family Physician 2006: 52: pp 171-172.
Koren G, Nava-Ocampo AA, Moretti ME, Sussman
R, Nulman I: Major malformations with valproic
acid. Canadian Family Physician 2006: 52:
pp 441-447.
Koren G, Soldin O: Therapeutic drug monitoring
of antithyroid drugs in pregnancy: The knowledge
gaps. Therapeutic Drug Monitoring 2006: 28:
pp 12-13.
Kosuge K, Chuang AI, Uematsu S, Tan KP, Ohashi
K, Ko BC, Ito S. Discovery of Osmo-sensitive
transcriptional regulation of human cytochrome
P450 3As (CYP3As) by the tonicity-responsive
enhancer binding protein (TonEBP/NFAT5).
Molecular Pharmacology June 28, 2007 (Epub
ahead of print).
Kozer E, Berkovitch M, Koren G: Medication errors
in children. Pediatric Clinics of North America
2006: 53: pp 1155-1168.
Kwok B, Yamauchi A, Rajesan R, Chen L, Dhillon
U, Gao W, Xu H, Wang B, Takahashi S, Semple J,
Tamai I, Nezu J, Tsuji A, Harper P, Ito S:
Carnitine/xenobiotics transporters in the human
mammary gland epithelia, MCF12A. American
Journal of Physiology: Regulatory, Integrative and
Comparative Physiology 2006: 290: pp 793-802.
Many A, Koren G: Toxoplasmosis during
pregnancy. Canadian Family Physician 2006:
52: pp 29-30.
Moretti ME, Verjee Z, Ito S, Koren G: Breastfeeding during maternal use of azathioprine.
Annals of Pharmacotherapy 2006: 40:
pp 2269-2272.
Nash K, Rovet J, Greenbaum R, Fantus E, Nulman
I, Koren G: Identifying the behavioural phenotype
in Fetal Alcohol Spectrum Disorder: Sensitivity,
specificity and screening potential. Archive of
Women’s Mental Health 2006: 9: pp 181-186.
Parshuram CS, Dupuis LL, To T, Weitzman SS,
Koren G, Laupacis A: Occurrence and impact of
unanticipated variation in intravenous
methotrexate dosing. Annals of Pharmacotherapy
2006: 40: pp 805-811.
Perri D, Dugoua JJ, Mills E, Koren G: Safety and
efficacy of Echinacea (Echinacea angustafolia,
e. purpurea and e. pallida) during pregnancy
and lactation. Canadian Journal of Clinical
Pharmacology 2006: 13: pp e262-e267.
Shrim A, Boskovic R, Maltepe C, Navioz Y, GarciaBournissen F, Koren G: Pregnancy outcome
following use of large doses of vitamin B6 in the
first trimester. Journal of Obstetrics and
Gynaecology 2006: 26: pp 749-751.
Shrim A, Garcia-Bournissen F, Koren G:
Pharmaceutical agents and pregnancy in urology
practice. Urologic Clinics of North America 2007:
34: pp 27-33.
Stade B, Ungar WJ, Stevens B, Beyene J, Koren G:
The burden of prenatal exposure to alcohol:
Measurement of cost. Journal of Fetal Alcohol
Syndrome International 2006: 4: p e5.
Stempak D, Gammon J, Halton J, Moghrabi A,
Koren G, Baruchel S: A pilot pharmacokinetic
and antiangiogenic biomarker study of celecoxib
and low-dose metronomic vinblastine or
cyclophosphamide in pediatric recurrent solid
tumors. Journal of Pediatric Hematology/Oncology
2006: 28: pp 720-728.
Sung L, Tomlinson GA, Greenberg ML, Koren G,
Judd P, Ota S, Feldman BM: Validation of the oral
mucositis assessment scale in pediatric cancer.
Pediatric Blood Cancer 2007: 49: pp 149-153.
BOOKS AND BOOK CHAPTERS
Addis A, Koren G: Safety of fluoxetine during the
first trimester of pregnancy: A meta-analytical
review of epidemiological studies. In: The
Evidence-Based, A To Z Clinician’s Pocket Guide,
Part II. McGraw Hill, New York, 2006.
Addis A, Moretti EM, Syed AF, Einarson RT, Koren
G: Fetal effects of cocaine: An updated metaanalysis. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part II. McGraw Hill,
New York, 2006.
Bar-Oz B, Hackman R, Einarson RT, Koren G:
Pregnancy outcome after cyclosporine therapy
during pregnancy: A meta-analysis. In: The
Evidence-Based, A To Z Clinician’s Pocket Guide,
Part II. McGraw Hill, New York, 2006.
Bar-Oz B, Moretti EM, Mareels G, Van Tittelboom
T, Koren G: Reporting bias in retrospective
ascertainment of drug-induced embryopathy. In:
The Evidence-Based, A To Z Clinician’s Pocket
Guide, Part II. McGraw Hill, New York, 2006.
Ben David S, Einarson RT, Ben David Y, Nulman I,
Pastuszak A, Koren G: The Safety of nitrofurantoin
during the first trimester of pregnancy: A metaanalysis. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part II. McGraw Hill,
New York, 2006.
Bennett AH, Einarson A, Taddio A, Koren G,
Einarson RT: Prevalence of depression during
pregnancy: Systematic review. In: The EvidenceBased, A To Z Clinician’s Pocket Guide, Part II.
McGraw Hill, New York, 2006.
Bentur Y, Koren G: Occupational exposures known
to be human reproductive poisons. In: The
Evidence-Based, A To Z Clinician’s Pocket Guide,
Part I. McGraw Hill, New York, 2006.
Bentur Y, Koren G: The common occupational
exposures encountered by pregnant women. In:
The Evidence-Based, A To Z Clinician’s Pocket
Guide, Part I. McGraw Hill, New York, 2006.
Bonari L, Pinto N, Ahn E, Einarson A, Steiner M,
Koren G: Perinatal risks of untreated depression
during pregnancy. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part II. McGraw Hill,
New York, 2006.
Burtin P, Taddio A, Ariburnu O, Einarson RT, Koren
G: Safety of metronidazole in pregnancy: A metaanalysis. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part II. McGraw Hill,
New York, 2006.
Gilbert C, Mazzotta P, Loebstein R, Koren G: Fetal
Safety of drugs used in the treatment of allergic
rhinitis: A critical review. In: The Evidence-Based,
A To Z Clinician’s Pocket Guide, Part II. McGraw
Hill, New York, 2006.
Cohen-Kerem R, Railton C, Oren D, Lishner M,
Koren G: Pregnancy outcome following nonobstetric surgical intervention. In: The EvidenceBased, A To Z Clinician’s Pocket Guide, Part II.
McGraw Hill, New York, 2006.
Gilbert C, Valois M, Koren G: Pregnancy outcome
after first-trimester exposure to metformin:
A meta-analysis. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part II. McGraw Hill,
New York, 2006.
Diav-Citrin Or, Koren G: Direct drug toxicity to
the fetus. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part I. McGraw Hill,
New York, 2006.
Goh YI, Bollano E, Einarson RT, Koren G: Prenatal
multivitamin supplementation and rates of
congenital anomalies: A meta-analysis. In: The
Evidence-Based, A To Z Clinician’s Pocket Guide,
Part II. McGraw Hill, New York, 2006.
Dolovich RL, Addis A, Vaillancourt JMR, Power
JDB, Koren G, Einarson, RT: Benzodiazepine
use in pregnancy and major malformations or
oral cleft: meta-analysis of cohort and casecontrol studies. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part II. McGraw Hill,
New York, 2006.
Goh YI, Koren G: Folic acid and congenital birth
defects: A review. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part I. In: The EvidenceBased, A To Z Clinician’s Pocket Guide, Part I.
McGraw Hill, New York, 2006.
Einarson RT, Leeder JS, Koren G: A method for
meta-analysis of epidemiological studies. In:
The Evidence-Based, A To Z Clinician’s Pocket
Guide de. Part II. McGraw Hill, New York, 2006.
Gutzin JS, Kozer E, Magee AL, Feig SD, Koren G:
The safety of oral hypoglycemic agents in the first
trimester of pregnancy: A meta-analysis. In: The
Evidence-Based, A To Z Clinician’s Pocket Guide,
Part II. McGraw Hill, New York, 2006.
Einarson RT, Koren G, Mattice D, Schechter-Tsafriri
C: Maternal spermicide use and adverse
reproductive outcome: A meta-analysis. In: The
Evidence-Based, A To Z Clinician’s Pocket Guide,
Part II. McGraw Hill, New York, 2006.
Hard LM, Einarson RT, Koren G: The role of
acetaldehyde in pregnancy outcome after prenatal
alcohol exposure. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part II. McGraw Hill, New
York, 2006.
Fernandes O, Sabharwal M, Smiley T, Pastuszak
A, Koren G, Einarson T: Moderate to heavy
caffeine consumption during pregnancy and
relationship to spontaneous abortion and
abnormal fetal growth: A meta-analysis. In:
The Evidence-Based, A To Z Clinician’s Pocket
Guide, Part II. McGraw Hill, Canada, 2007.
Hemels EHM, Einarson A, Koren G, Lanctot LK,
Einarson RT: Antidepressant use during pregnancy
and the rates of spontaneous abortions: A metaanalysis. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part II. McGraw Hill,
New York, 2006.
Fried S, Kozer E, Nulman I, Einarson RT, Koren G:
Malformation Rates in children of women with
untreated epilepsy: A meta-analysis. In: The
Evidence-Based, A To Z Clinician’s Pocket Guide,
Part II. McGraw Hill, New York, 2006.
Gareri J, Klein J, Koren G: Determination of
prenatal exposures: In: The Evidence-Based, A To
Z Clinician’s Pocket Guide, Part I. McGraw Hill,
New York, 2006.
Gedeon C, Koren G: Gestational changes in drug
disposition in the maternal-fetal unit. In: The
Evidence-Based, A To Z Clinician’s Pocket Guide,
Part I. McGraw Hill, New York, 2006.
Koren G: Medication in pregnancy and
breastfeeding. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part I. McGraw Hill,
New York, 2006.
Koren G: Risk of varicella infection during late
pregnancy. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part II. McGraw Hill,
New York, 2006.
Koren G: Drugs in pregnancy: Acknowledging
challenges-finding solutions. In: The EvidenceBased, A To Z Clinician’s Pocket Guide, Part I.
McGraw Hill, New York, 2006.
Koren G: Bias against the null hypothesis in
maternal-fetal pharmacology and toxicology. In:
The Evidence-Based, A To Z Clinician’s Pocket
Guide, Part II. McGraw Hill, New York, 2006.
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
27
Koren G, Nava-Ocampo A A, Moretti EM, Sussman
R, Nulman I: Major malformations with valproic
acid. In: The Evidence-Based, A To Z Clinician’s
Pocket Guide, Part II, McGraw Hill, New York,
2006.
Kozer E, Nikfar S, Costei A, Boskovic R, Nulman I,
Koren G. Aspirin consumption during the first
trimester of pregnancy and congenital anomalies:
A meta-analysis. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part II. McGraw Hill,
New York, 2006.
Magee AL, Elran E, Bull BS, Logan A, Koren G.
Risks and benefits of beta-receptor blockers
for pregnancy hypertension: Overview of the
randomized trials. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part II. McGraw Hill,
New York, 2006.
Magee AL, Mazzotta P, Koren G. Evidence-based
view of safety and effectiveness of pharmacologic
therapy for nausea and vomiting of pregnancy
(NVP). In: The Evidence-Based, A To Z Clinician’s
Pocket Guide, Part II. McGraw Hill, New York,
2006.
Makarechian N, Agro K, Devline J, Trepanier E,
Koren G, Einarson RT. Association between
moderate alcohol consumption during pregnancy
and spontaneous abortion, stillbirth and
premature birth: A meta-analysis. In: The
Evidence-Based, A To Z Clinician’s Pocket Guide,
McGraw Hill, New York, 2006.
McMartin IK, Chu M, Kopecky E, Einarson RT,
Koren G. Pregnancy outcome following maternal
organic solvent exposure: A meta-analysis of
epidemiologic studies. In: The Evidence-Based,
A To Z Clinician’s Pocket Guide, Part II. McGraw
Hill, New York, 2006.
Moretti EM, Bar-Oz B, Fried S, Koren G. Maternal
hyperthermia and the risk for neural tube defects
in offspring: systematic review and meta-analysis.
In: The Evidence-Based, A To Z Clinician’s Pocket
Guide, Part II. McGraw Hill, New York, 2006.
Nava-Ocampo AA, Talaie H, Koren G: Systematic
Review of randomized controlled trials and cohort
studies on pregnancy outcome following
antiretroviral treatment in pregnancy. In: The
Evidence-Based, A To Z Clinician’s Pocket Guide,
Part II. McGraw Hill, New York, 2006.
Nikfar S, Abdollahi M, Moretti EM, Magee AL,
Koren G: Use of proton pump inhibitors during
pregnancy and rates of major malformations: A
meta-analysis. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part II. McGraw Hill,
New York, 2006.
28
DEPARTMENT OF PAEDIATRICS
Nulman I, Izmaylov Y, Staroselsky A, Koren G:
Teratogenic drugs and chemicals in humans.
In: The Evidence-Based, A To Z Clinician’s Pocket
Guide, Part I. McGraw Hill, New York, 2006.
Nulman I, Knittel-Kerem D, Koren G: Fetal
Alcohol Spectrum Disorder: The central nervous
system tragedy. In: The Evidence-Based, A To Z
Clinician’s Pocket Guide, Part I. McGraw Hill,
New York, 2006.
Nulman I, Koren G: Epilepsy and pregnancy. In:
The Evidence-Based, A To Z Clinician’s Pocket
Guide, Part I. McGraw Hill, New York, 2006.
Nulman I, Laslo D, Fried S, Uleryk E, Lishner M,
Koren G: Neurodevelopment of children exposed
in utero to treatment of maternal malignancy.
In: The Evidence-Based, A To Z Clinician’s Pocket
Guide, Part II. McGraw Hill, New York, 2006.
Nulman I, Sussman R, Farber N, Chitayat D, Koren
G: Fetal malformations associated with drugs and
chemicals: Visualization by sonography/fetal MRI.
In: The Evidence-Based, A To Z Clinician’s Pocket
Guide, Part I. McGraw Hill, New York, 2006.
Park-Wyllie L, Mazotta P, Pastuszak, A, Moretti EM,
Beique L, Hunnisett L, Friesen HM, Jacobson S,
Kasapinovic S, Chang D, Diav-Citrin O, Chitayat D,
Nulman I, Einarson RT, Koren G: Birth defects
after maternal exposure to corticosteroids:
Prospective cohort study and meta-analysis of
epidemiological studies. In: The Evidence-Based,
A To Z Clinician’s Pocket Guide, Part II. McGraw
Hill, New York, 2006.
Polygenis D, Wharton S, Malmberg C, Sherman N,
Kennedy D, Koren G, Einarson RT: Moderate
alcohol consumption during pregnancy and the
incidence of fetal malformations: A meta-analysis.
In: The Evidence-Based, A To Z Clinician’s Pocket
Guide, Part II. McGraw Hill, New York, 2006.
Raman-Wilms L, Tseng LAl, Wighardt S, Einarson
RT, Koren G: Fetal genital effects of first-trimester
sex hormone exposure: a meta-analysis. In: The
Evidence-Based, A To Z Clinician’s Pocket Guide,
Part II. McGraw Hill, Canada, 2006.
Seto A, Einarson RT, Koren G: Pregnancy
outcome following first trimester exposure to
antihistamines: A meta-analysis. In: The EvidenceBased, A To Z Clinician’s Pocket Guide, Part II.
McGraw Hill, New York, 2006.
Seto A, Einarson RT, Koren G: Evaluation of
brompheniramine safety in pregnancy. In:
The Evidence-Based, A To Z Clinician’s Pocket
Guide, Part II. McGraw Hill, New York, 2006.
Sivojelezova A, Gallo M, Bollano E, Boom H,
Koren G: The use of natural health products in
pregnancy and lactation. In: The Evidence-Based,
A To Z Clinician’s Pocket Guide, Part I. McGraw
Hill, New York, 2006.
ANNUAL REPORT 2006-07
von Dadelszen P, Ornstein, MP, Bull, SB, Logan
AG, Koren, G, Magee AL: Fall in mean arterial
pressure and fetal growth restriction in pregnancy
hypertension: A meta-analysis. In: The EvidenceBased, A To Z Clinician’s Pocket Guide, Part II.
McGraw Hill, New York, 2006.
FUNDING
Child neurodevelopment and pharmacokinetic
correlations following treatment with supratherapeutic doses of Diclectin for nausea and
vomiting of pregnancy. Nulman I. Canadian
Institutes of Health Research ($487,600 and
$68,267 2006)
Child neurodevelopment following in utero
exposure to maternal azathioprine. Nulman I.
Physicians’ Services Incorporated Foundation
($146,000 2006)
Determinants of renal handling of drugs during
development. Koren G, Ito S. Canadian Institutes
of Health Research ($160,000 2003-2008)
Determinants of renal handling of drugs during
development. Koren G. Canadian Institutes of
Health Research ($583,800 2003-2008)
Drugs and human milk. Ito S. Canadian Institutes
of Health Research ($645,998 2002-2007)
Genotype-specific approaches in therapeutics in
children. Carlton B, Hayden M, Ito S. UBC
($105,000 2005-2007)
Hair analysis for cortisol and testosterone. VanUm
S, Koren G. Physicians’ Services Incorporated
Foundation ($130,000 2006-2008)
Improving prenatal vitamins to women. Koren G.
Duchesnay Incorporated ($400,000 2004-2007)
New Emerging Team (NET) grant. Koren G,
Brien J. Canadian Institutes for Health Research
($1,250,000 2002-2007)
Neurodevelopment after fetal exposure to
venlafaxine. Nulman I, Koren G. Wyeth
Incorporated ($120,000 2004-2006)
Neurodevelopment after fetal exposure to
supradose diclectin. Koren G, Nulman I.
Duchesnay Incorporated ($480,000 2005-2008)
Novel transcriptional control of human CYP3A.
Ito S. Canadian Institutes of Health Research
($340,540 2006-2009)
Pharmacogenetics of adverse drug reactions in
children. Carlton B, Hayden M, Ito S, Koren G.
Genome Canada ($350,000 2005-2008)
The role of placenta in fetal toxicology. Koren G,
Derewlany L, Einarson T. Canadian Institutes of
Health Research ($584,309 2002-2006)
Developmental Paediatrics
DIVISIONAL OVERVIEW
The Division of Developmental Paediatrics was created within the
Faculty of Medicine’s Department of Paediatrics effective March 1,
2005 in response to recent major advances in this important area
of paediatrics. The Royal College of Physicians and Surgeons of
Canada has recognized that developmental paediatrics represents
a defined body of knowledge meriting recognition as a separate
subspecialty area within paediatrics. The training program at the
University of Toronto was granted “full accredited with
certification” status by the College. SickKids and Bloorview Kids
Rehab (formerly Bloorview MacMillan Children’s Centre) have
created an enhanced child development program which provides a
single access point and triage system for families and consolidates
resources. As well, leaders at SickKids and Bloorview Kids Rehab
research institutes are working closely together to augment
research activities related to developmental disorders.
HONOURS AND AWARDS
Jethwa A: The Roszel Developmental Paediatric
Research Award, 2007
PUBLICATIONS
Biggar WD: Duchenne muscular dystrophy.
Pediatrics in Review 2006: 27: pp 83-87.
Biggar WD, Harris VA, Eliasoph L, Alman B: Longterm benefits of delfazacort treatment for boys
with Duchenne muscular dystrophy in their second
decade. Neuromuscular Disorders 2006: 16:
pp 249-255.
Bryson SE, Zwaigenbaum L, Brian JA, Roberts SW,
Szatmari P, Rombough V, McDermott C: A
prospective case series of high-risk infants who
developed autism. Journal of Autism and
Developmental Disorders 2007: 37: pp 12-24.
Doja A, Roberts SW: Immunizations and autism.
Canadian Journal of Neurological Sciences 2006:
33: pp 341-346.
Dorota A, Kwasnicka-Crawford, Roberts W, Scherer
SW: Characterization of an autism-associated
segmental maternal heterodisomy of the
chromosome 15q11-13 region. Journal of Autism
Developmental Disorders 2006: 37: pp 694-702.
Division Head
Dr. Golda Milo-Manson
(2006-2007)
Dr. Darcy Fehlings
(2007-present)
Physicians
Dr. Douglas Biggar
Dr. Darcy Fehlings
Dr. Cynthia Goldfarb
Dr. Elizabeth Jimenez
Dr. Tamarah
Kagan-Kushnir
Dosman C, Brian J, Drmic I, Senthilselvan A,
Harford M, Smith R, Sharieff W, Moldofsky H,
Zlotkin S, Roberts W: Children with autism: Effect
of iron supplementation on sleep and ferritin.
Pediatric Neurology 2007: 36: pp 152-158.
Dosman C, Drmic I, Brian J, Senthilselvan A,
Harford M, Smith R, Roberts W: Ferritin as an
indicator of suspected iron deficiency in children
with autism spectrum disorder: Prevalance of low
serum ferritin concentration. Developmental
Medicine and Child Neurology 2006: 48:
pp 1008-1009.
Feuk L, Kalervo A, Lipsanen-Nyman M, Skaug J,
Kazuhiko N, Finucane B, Hartung D, Innes M,
Kerem B, Nowaczyk MJ, Rivlin J, Roberts W,
Senman L, Summers A, Szatmari P, Wong V,
Vincent JB, Zeesman S, Osborne LR, Oram Cardy
J, Kere J, Scherer SW, Hannula-Jouppi K: Absence
of a paternally-inherited FOXP2 gene in
developmental verbal dyspraxia. American Journal
of Human Genetics 2006: 79: pp 965-972.
Georgiades S, Szatmari P, Zwaigenbaum L, Duku
E, Bryson S, Roberts W, Goldberg J, Mahoney W:
The structure of the autism symptom phenotype:
A proposed multidimensional model. Journal of
the American Academy of Child and Adolescent
Psychiatry 2007: 46: pp 188-196.
Dr. Anne Kawamura
Dr. Tara Kennedy
Dr. Peggy Kirkpatrick
Dr. Alvin Loh
Dr. Golda Milo-Manson
Dr. Wendy Roberts
Dr. Jay Rosenfield
Fellows
Dr. Christakis Christofi
Dr. Anita Jethwa
Dr. Kassia Johnson
Dr. Angelina Orsino
Dr. Jonathan Ponesse
Dr. Lyn Sonnenberg
Ickowicz A, Feng Y, Wigg K, Quist J, Pathare T,
Roberts W, Malone M, Schachar R, Tannock R,
Kennedy JL, Barr CL: The serotonin receptor
HTR1B: Gene polymorphisms in attention deficit
hyperactivity disorder. Neuropsychiatric Genetics
2007: 144: pp 121-125.
Kawamura A, Campbell K, Lam-Damji S., Fehlings
D: A randomized controlled trial comparing
botulinum toxin A dosage in the upper extremity
of children with spasticity. Developmental
Medicine and Child Neurology 2007: 49:
pp 331-337.
Loh A, Soman T, Brian J, Bryson SE, Roberts W,
Szatmari P, Smith I, Zwaigenbaum L: Stereotyped
motor behaviors associated with autism in highrisk infants: A pilot videotape analysis of a sibling
sample. Journal of Autism and Developmental
Disabilities 2007: 37: pp 25-36.
Mitchell S, Brian J, Zwaigenbaum L, Roberts W,
Szatmari P, Smith I, Bryson S: Early language and
communication development of infants later
diagnosed with autism spectrum disorder. Journal
of Developmental and Behavioral Pediatrics
2006: 27: pp S69-S78.
Administrative Staff
at SickKids
Maureen Hodge
Barbara Zimnowodzki
Administrative Staff
at Bloorview Kids Rehab
Romana Karnetova
Narayanan U, Fehlings D, Weir S, Knights S, Kiran
S, Campbelll K: Initial development and validation
of the caregiver priorities and Child Health Index
of Life with Disabilities (CPCHILD). Developmental
Medicine and Child Neurology 2006: 48:
pp 804-812.
Rubinstein S, Malone MA, Roberts W, Logan WJ:
Placebo-controlled study examining effects
of selegiline in children with attention deficit
hyperactivity disorder. Journal of Child &
Adolescent Psychopharmacology 2006: 16(4):
pp 404-415.
Sanger T, Chen D, Delgado M, Gaebler-Spira D,
Hallett M, Mink J, and the Taskforce on Childhood
Motor Disorders (Fehlings D, Member): Definition
and classification of negative motor signs in
childhood. Pediatrics 2006: 118: pp 2159-2167.
Szatmari P, Georgiades S, Bryson S, Zwaigenbaum
L, Roberts W, Mahoney W, Goldberg J, Tuff L:
Investigating the structure of the restricted,
repetitive behaviours and interests domain of
autism. Journal of Child Psychology & Psychiatry
2006: 47: pp 582-590.
Scherer SW, Szatmari P, Roberts W
(The Autism Genome Project Consortium):
Mapping autism risk loci using genetic linkage and
chromosomal rearrangements. Nature Genetics
2007: 39: pp 319-328.
Scherer SW, Vincent JB, Horike S, Choufani S,
Paterson AD, Roberts W, Szatmari P, Weksberg R,
Fernandez BA: An inversion in autistic siblings
implicates the 4p GABA receptor gene cluster.
Journal of Medical Genetics 2006: 43:
pp 429-434.
Vajsar J, Zhang W, Dobyns WB, Biggar WD, Holden
KR, Hawkins C, Ray P, Olney AH, Burson CM,
Srivastava AK, Schachter H: Carriers and patients
with muscle-eye-brain disease can be rapidly
diagnosed by enzymatic analysis of fibroblasts
and lymphoblasts. Neuromuscular Disorders
2006: 16: pp 132-136.
Young N, Gilbert T, McCormick A, Ayling-Campos
A, Law M, Fehlings D, Mukherjee S, Wedge J,
Rumney P, Williams JI: Youth and young adults
with cerebral palsy: Their use of physician and
hospital services. Archives of Physical Medicine
and Rehabilitation 2007: 88: pp 696-702.
Young N, McCormick A, Mills W, Barden W,
Boydell K, Wedge J, Fehlings D, Mukherjee S,
Rumney P, Williams J: The transition study:
A look at youth and adults with cerebral palsy,
spina bifida and acquired brain injury.
Physical and Occupational Therapy in Pediatrics
2006: 26: pp 25-45.
30
DEPARTMENT OF PAEDIATRICS
BOOKS AND BOOK CHAPTERS
Fehlings D, Hunt C, Rosenbaum P: Cerebral palsy.
In: A Comprehensive Guide to Intellectual &
Developmental Disabilities (Brown I, Percy M,
eds). Paul H. Brookes Publishing Inc., Baltimore,
2007.
Weiss S, Milo-Manson G, MacFarlane J. Better
Sleep for Your Baby and Child. Robert Rose
Publishers, Toronto, 2006.
FUNDING
A joint Canadian and Hong Kong, China initiative
in the study of autism spectrum disorders.
Scherer SW, Szatmari P, Roberts W. Canadian
Institutes of Health Research ($24,720
2005-2006)
Autism genome project. Scherer SW, Szatmari P,
Paterson AD, Vincent JB, Zwaigenbaum L, Roberts
W, Wellington SR, Fernandez BA, Miller FA,
Hallmayer JF. Genome Canada ($15,611,534
2005-2009)
Autism spectrum disorders: Pathways to better
outcomes. Szatmari P, Bryson SE, Fombonne E,
Zwaigenbaum L, Smith I, Waddell C, Vaillancourt
T, Mirenda P, Roberts W, Volden J. Canadian
Institutes of Health Research ($2,125,415
2004-2009)
Development and reliability testing of a new
observational gait assessment for children with
cerebral palsy. Wright V, Fehlings D. Bloorview
Research Institute Seed Grant ($24,952
2006-2007)
Early developmental trajectories in autism.
Zwaigenbaum L, Bryson SE, Roberts SW, Smith I,
Szatmari, Vaillancourt T. Canadian Institutes of
Health Research ($932,585 2006-2011)
Enhancing inter-subjectivity in infants at high-risk
for autism. Bryson S, Brian J, Smith I,
Zwaigenbaum L, Roberts SW. Autism Speaks
($638,006 2007-2010)
Evaluating outcomes associated with
multidisciplinary care for children with cerebral
palsy using clinical practice improvement (CPI)
methodology. Damiano D, Chambers H, Revivo G,
Brunstrom J, Horn S, Gassaway J, Krach L,
Gormley M, Novacheck T, Matthews D, Chang F,
Stevenson R, Abel M, McLaughlin J, Bjornson K,
Rathjen K, Delgado M, Dabrowski E, Gaebler-Spira
D, Dias L, Narayanan U, Fehlings D, Graham K,
Koman A. American Academy for Cerebral Palsy
and Developmental Medicine Clinical Research
Planning Grant ($29,000 2006-2007)
Evaluation of the reliability, validity and
responsiveness of the Kinematic Dystonia
Measure in children with upper extremity dystonia.
Kawamura A, Fehlings D, Morris A, Campbell K.
Bloorview Research Institute Seed Grant
($16,652 2007)
ANNUAL REPORT 2006-07
Evaluation with a message: Interprofessional
assessment of professionalism. Milo-Manson G,
Kennedy T. Royal College of Physicians &
Surgeons of Canada Medical Education Grant
($11,125 2006)
Functional outcomes following orthopaedic
surgery based on gait laboratory versus
observational gait analysis in ambulatory children
with cerebral palsy: A randomized controlled trial.
Narayanan U, Fehlings D, Weir S. Pediatric
Orthopaedic Society of North America (POSNA)
($31,000 2006-2008)
Functional outcomes following orthopaedic
surgery based on gait laboratory versus
observational gait analysis in ambulatory children
with cerebral palsy: A pilot randomized controlled
trial. Narayanan U, Fehlings D, Weir S. Bloorview
Research Institute Seed Grant Competition
($25,015 2006-2007)
Genetic epidemiology of autism: Family and
molecular studies. Szatmari P, Bryson S, Goldberg
J, Patterson A, Mahoney W, Merette C, Roberts W,
Zwaigenbaum L, Scherer S. Canadian Institutes of
Health Research ($725,000 2003-2008)
Identifying early markers of autism: A prospective
study of infant siblings. Zwaigenbaum L, Roberts
SW, Smith I, Szatmari P, Bryson SE. Canadian
Institutes of Health Research ($331,650 20032006)
Interprofessional Disaster/ Emergency Action
Studies (�IDEAS’): Promoting interprofessional
collaboration and team building to deliver safe
and effective casualty and patient-centred
practice in disasters/emergencies and
pandemics. Rosenfield J (Member of Steering
Committee). Health Canada Interprofessional
Education for Collaborative Patient-Centred
Practice (IECPCP) ($792,011 2006-2007)
Neuroimaging and frontal lobe function in children
with autism. Taylor M, Roberts SW, Donner EJ,
Bayless S, Shroff M. National Alliance for Autism
Research ($115,907 2006-2008)
The development and evaluation of the HAT-D:
A discriminative tool differentiating types of
hypertonia in children. Fehlings D, Jethwa A,
Macarthur C. The Bloorview Research Institute
($9,606 2006-2007)
The efficacy of an intelligent prompting system to
develop self-care activities in children with autism.
Mihailidis A, Roberts SW, Polatajko H, Chau T.
SickKids Foundation and Canadian Institutes of
Health Research ($129,470 2007-2009)
Training program in autism research. Fombonne E,
Bryson S, Paterson A, Scherer S, Roberts W,
Szatmari P, Smith I, Moore C. Canadian Institutes
of Health Research, National Alliance for Autism
Research and Fonds de la Recherche en Sante
du Quebec ($1,440,000 2003-2009)
Dr. Darcy Fehlings
Murphy AM, Fehlings D, Milo-Manson G, Best A,
Campbell K: An evaluation of modafanil on
spasticity reduction, function and quality of life in
children with CP. Developmental Medicine & Child
Neurology 2006: 48: p 12.
Acting Division Head
Dr. Diane Wherrett
Full-Time
Dr. Denis Daneman
Dr. Jill Hamilton
Dr. Kusiel Perlman
Dr. Etienne Sochett
Part-Time
Dr. Jacqueline Curtis
Dr. Susan Kirsch
Dr. Stacey Urbach
Gynaecology
Dr. Lisa Allen
Dr. Nicolette Caccia
Dr. Sari Kives
Dr. Melanie Ornstein
Honorary
Dr. Robert Ehrlich
Dr. Dror Koltin
Dr. Clodagh O’Gorman
Gynaecology Fellows
Dr. Rachel Spitzer
Subspecialty Residents/
Clinical Fellows
Dr. Abdulla Aljunaibi
Dr. Bojana Babic
Dr. Louise Conwell
Dr. Ara Healey
Research Fellows
Dr. Shazhan Amed
Dr. David Cherney
Dr. Meranda Nakhla
Cross-Appointees
Dr. Amira Klip
Dr. Joanne Rovet
Administrative Staff
Mira Milne
Joyce Robinson
Minet Smith
Zarine Tilak
Endocrinology
DIVISIONAL OVERVIEW
2006-2007 continued to be a highly productive time for the
Division of Endocrinology with ongoing development of existing
programs and new innovations. We have had eight trainees in
our subspecialty training program: four Canadian, one Israeli,
one Australian, one Irish and one from the UAE. It has also
been a year of changes, as Dr. Denis Daneman is now Chair of
Paediatrics and Paediatrician in Chief at The Hospital for Sick
Children. Dr. Diane Wherrett has been acting division head
for the past year. Dr. Mark Palmert will be joining the division as
the new head in September 2007.
Our research efforts have targeted the following areas:
(i) prediction and prevention of type 1 diabetes: our group is
involved in the multinational TrialNet and TRIGR study groups;
(ii) implications of insulin resistance and obesity in children and
adolescents and the evolution of them in young children;
(iii) study of the factors affecting metabolic control and the early
complications of diabetes; (iv) psychosocial and psychological
outcomes in diabetes and other endocrine disorders;
and (v) evaluation of disorders of calcium and bone mineral
metabolism in paediatrics.
Dr. Diane Wherrett with clinic staff
Our areas of clinical focus continue to be: (i) Diabetes: our
comprehensive program provides ongoing care to nearly 1,000
children and teens with diabetes, including a program for
comprehensive assessment and treatment for adolescents with
chronically poor diabetes control; (ii) General Endocrinology
emphasizing the areas of growth, thyroid disease, intersex
conditions and reproductive health; (iii) Calcium: the Calcium-Bone
and Osteoporosis Clinics assess children with abnormal bone
health from a wide variety of causes; (iv) Gynaecology section:
provides care to pre-teen and adolescent girls across a wide
spectrum of disorders. Recent initiatives include the development
of pathways for the care of children with thyroid cancer in
collaboration with Oncology, Otolaryngology and Nuclear Medicine.
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
33
HONOURS AND AWARDS
Aggarwal L, Thomas M, Spitzer R, Stephens D,
Kives S, Allen L: Methotrexate in the management
of adolescents with ectopic pregnancies: A
physician survey. SOGC Poster Gynaecology Junior
Members Award, 2007
Hamilton J: NovoNordisk Young Investigator Career
Development Award, 2006-2007.
Hamilton J: The Hospital for Sick Children,
Department of Paediatrics Richard Rowe Junior
Faculty Award for Excellence in Clinical Medicine –
Runner Up, 2006.
Klip A: Editor-in-Chief, The American Journal of
Physiology – Endocrinology and Metabolism
Physiology, 2007.
Hoey H, McGee HM, Fitzgerald M, Mortensen HB,
Hougaard P, Lynggaard H, Skovlund SE, Aanstoot
HJ, Chiarelli F, Daneman D, Danne T, Dorchy H,
Garandeau P, Greene S, Holl R, Kaprio E, Kocova
M, Martul P, Matsuura N, Robertson K, Schoenle
E, Sovik O, Swift P, Tsou RM, Vanelli M, Aman J;
for the Hvidore Study Group on Childhood
Diabetes: Parent and health professional
perspectives in the management of adolescents
with diabetes: Development of assessment
instruments for international studies. Quality of
Life Research 2006: 15: pp 1033-1042.
Nash K, Rovet J, Greenbaum R, Fantus E, Koren
G: Defining the behavioural phenotype in children
with Fetal Alcohol Spectrum Disorder (FASD):
Sensitivity, specificity and screening potential.
Archives of Women’s Mental Health 2006: 9:
pp 181-186
Huang C, Ezzat S, Asa S, Hamilton J:
Dopaminergic resistant prolactinomas in the
peripubertal population. Journal of Pediatric
Endocrinology and Metabolism 2006: 19:
pp 951-954.
Ong G, Hamilton J, Sermer M, Connelly PW,
Maguire G, Zinman B, Hanley AJ, Retnakaran R:
Maternal serum adiponectin and infant
birthweight: The role of adiponectin isoform
distribution. Clinical Endocrinology April 27, 2007
[Epub ahead of print].
PUBLICATIONS
Al-Jenaidi F, Makitie O, Grubenbaum E, Sochett E:
Hypoparathyroidism in 22q11.2 deletion
syndrome; follow up and relationship to
associated clinical features. Hormone Research
2006: 67: pp 117-122.
Ishikura S, Bilan PJ, Klip A: Rabs 8A and 14
are targets of the insulin-regulated Rab-GAP
AS160 regulating GLUT4 traffic in muscle cells.
Biochemical and Biophysical Research
Communications 2007: 353: pp 1074-1079.
Becker DV, Braverman LE, Delange F, Franklyn JA,
Hollowell JG, Lamm SH, Mitchell ML, Pearce E,
Robbins J, Rovet J: Iodine supplementation
for pregnancy and lactation – United States and
Canada: Recommendations of the American
Thyroid Association. Thyroid 2006: 16:
pp 949-951.
JeBailey L, Wanono O, Niu W, Roessler J, Rudich
A, Klip A: Ceramide- and oxidant-induced insulin
resistance involve loss of insulin-dependent
Rac-Activation and Actin remodeling in muscle
cells. Diabetes 2007: 56: pp 394-403.
Caprara D, Nash K, Greenbaum R, Rovet J, Koren
G: Novel approaches to the diagnosis of Fetal
Alcohol Spectrum Disorder. Neuroscience &
Biobehavioral Reviews 2007: 31: pp 254-260.
Dunger D, Schwarze CP, Cooper JD, Widmer B,
Neil HA, Shield J, Edge JA, Jones TW, Daneman D,
Dalton RN: Can we identify adolescents at high
risk for nephropathy before the development of
microalbuminuria? Diabetic Medicine 2007: 24:
pp 131-136.
Greenberg ML, Urbach SL: Preserving the fertility
of children with cancer. Medical Journal of
Australia 2006: 185: pp 532-533.
Hamilton J, Skrivarhaug T: ISPAD 2006 –
Highlights from the 32nd Annual Scientific
Meeting, Cambridge, UK. Paediatric Diabetes
2006: 7: pp 336-340.
Kives S: The IUCD – Is it an acceptable option
for the adolescent? Journal of Pediatric and
Adolescent Gynecology 2006: 19: p 301.
Klip A, Vranic M: Muscle, liver, and pancreas:
Three Musketeers fighting to control glycemia.
American Journal of Physiology – Endocrinology
and Metabolism 2006: 291: pp e1141-e1143.
Lacy J, Brennand E, Ornstein M, Allen L: Vaginal
laceration from a high-pressure water jet in a
prepubescent girl. Pediatric Emergency Care
2007: 23: pp 112-114.
Lacy J, Capra M, Allen L: Endodermal sinus
tumor of the infant vagina treated exclusively
with chemotherapy. Journal of Pediatric
Hematology/Oncology 2006: 28: pp 768-771.
Lam C, Tjon J, Hamilton J, Ahmet A: Recurrent
anaphylaxis associated with gonadotropin
releasing hormone analogues: Case report and
literature review. Pharmacotherapy 2006: 26:
pp 1811-1815.
Milic A, Asch MR, Hawrlyshyn PA, Allen LM,
Colgan TJ, Kachura JR, Hayeems EB: Laparoscopic
ultrasound guided radiofrequency ablation of
uterine fibroids. Cardiovascular & Interventional
Radiology 2006: 29: pp 694-698.
Nathan PC, Jovcevska V, D’Agostino N, Staneland
P, Urbach SL, Barron M, Barrera M, Greenberg ML:
The prevalence of overweight and obesity in
pediatric survivors of childhood cancer. Journal of
Pediatrics 2006: 149: pp 518-525.
Rachmiel M, Charron M, Gupta A, Hamilton J,
Wherrett D, Forte V, Daneman D: Evidence-based
review of treatment and follow-up of pediatric
patients with differentiated thyroid cancer. Journal
of Pediatric Endocrinology and Metabolism 2006:
19: pp 1377-1394.
Rachmiel M, Rota V, Atenafu E, Daneman D,
Hamilton J: Final height in children with idiopathic
growth hormone deficiency treated with a fixed
dose of recombinant growth hormone. Hormone
Research 2007: 68: pp 236-243.
Thong F, Bilan PJ, Klip A: The Rab GTPaseactivating protein AS160 integrates Akt, protein
kinase C, and AMP-activated protein kinase
signals regulating GLUT4 traffic. Diabetes 2007:
56: pp 414-443.
Wolfsdorf J, Craig ME, Daneman D, Dunger D,
Edge J, Warren LW, Rosenbloom A, Sperling MA,
Hanas R: Diabetic ketoacidosis. Pediatric
Diabetes 2007: 8: pp 28-43.
Zdravkovic V, Hamilton J, Daneman D, Cummings
E: Pioglitazone as adjunctive therapy in
adolescents with Type 1 diabetes. Journal of
Pediatrics 2006: 149: pp 845-849.
BOOKS AND BOOK CHAPTERS
Perlman K. Management of Diabetes Mellitus in
Children and Adolescents in Approach to the
Management of Diabetes Mellitus. Banting and
Best Diabetes Centre, Toronto, 2006.
Till C, Koren G, Rovet J. Effects of organic solvents
on reproductive outcome and offspring
neurodevelopment. In: Human Developmental
Neurotoxicology (Bellinger DC, ed). Taylor &
Francis, New York, 2006.
FUNDING
Bridging the paediatric and adult health care
environment: Promoting successful transitions for
survivors of paediatric cancer. Greenberg M,
D’Agostino N, Guger S, Staneland P, Lough M,
Laperriere N, Urbach SL, Nathan PC. Princess
Margaret Hospital Psychosocial Oncology and
Palliative Care Grant Competition ($5,986
2006-2007)
Bypassing insulin resistance of muscle cells
caused by ceramide, oxidative stress and
macrophage-co-culture. Klip A. Canadian Diabetes
Association ($300,000 2006-2009)
Combined diazoxide and metformin therapy in
children with hypothalamic obesity secondary to
craniopharyngioma: A Pilot Study. Hamilton J,
Daneman D, Ahmet A. Canadian Institutes of
Health Research ($49,500 2006-2008)
Comparison of continuous versus cyclic use of a
30-MCG ethinyl estradiol 0.15 mg desogestrel
oral contraceptive pill in adolescents. Allen L,
Brown C. Azko Nobel – Organon Canada
($24,500 2006-2008)
Comparison of continuous versus cyclic use of a
30-MCG ethinyl estradiol 0.15 mg desogestrel
oral contraceptive pill in adolescents. Allen L,
Brown C. Physicians’ Services Incorporated
Foundation ($75,000 2006-2008)
Cross-sectional study of overweight in paediatric
survivors of acute lymphoblastic leukemia. Nathan
PC, Urbach SL, Barrera M, Barron M, D’Agostino
N, Staneland P, Charron, Greenberg ML. The
University of Toronto, Faculty of Medicine Dean’s
Fund ($9,998 2007)
Evaluation of hepatic function and autoimmunity
in girls with Turner Syndrome. Hamilton J,
McAssey K, Milkiewicz P, Heathcote J, Norman G.
Hoffman-La Roche Canada ($23,980 2006-2007)
Fetal alcohol syndrome: Oxidative stress and
innovative therapies: (Aiii) Structural
manifestations of FAS/ARND brain injury. Rovet J.
Canadian Institutes of Health Research New
Emerging Team Grant ($50,000 2002-2007)
Growth hormone therapy and bone quality in
paediatric osteoporosis. Sochett E, Grynpas M.
Eli Lilly Canada ($125,000 2006-2009)
Hemodynamic modulation in type 1 diabetes.
Miller J, Sochett E, Cherney D. Canadian
Institutes of Health Research ($105,000
2007-2012)
Post marketing surveillance program for Protropin
and Nutropin. Hamilton J. Primary Investigator
SickKids site. Genentech National Cooperative
Growth Study (NCGS) ($35,300 2001-2007)
The comprehensive care clinic for children with
central tumours at The Hospital for Sick Children:
Evaluating the efficacy of an integrated,
multidisciplinary model of care for children with
hypothalamic dysfunction. Hamilton J, Barrera M,
Guger S, Popov T, Schulte F. b.r.a.i.n.child,
The Hospital for Sick Children ($27,931.36
2006-2008)
The genetics and neuroendocrinology of short
stature. Hamilton J. Primary Investigator SickKids
site. Lilly International Growth Study (GeNeSIS)
($58,542 2002-2007)
Hormonal regulation of p38MAPK and its
implications for glucose transport. Klip A.
Canadian Institutes of Health Research
($643,800 2002-2007)
Insulin resistance and beta cell dysfunction in
early childhood: The role of maternal and infant
metabolic risk factors. Hamilton J, Hanley A,
Retnakaran R, Zinman B. Canadian Institutes of
Health Research ($341,706 2005-2008)
Insulin sensitization by muscle contraction
pathways: implications for insulin resistance. Klip
A. Canadian Institutes of Health Research/
National Natural Science Foundation of China –
Canada Joint Health Research Initiative – Grants
Program ($90,000 2006-2009)
Intracellular compartment plasticity and signal
transmission in insulin action. Klip A. Canadian
Institutes of Health Research ($759,560
2005-2010)
The GH Monitor registration. Hamilton J, Daneman
D, Geary D, Perlman K, Hebert D, Sochett E,
Langlois V, Wherrett D, Perl R. Serono Canada
Incorporated ($1,200 2005-2008)
Thyroid hormone insufficiencies and visual
perceptual deficits in preterm infants. Rovet J,
Westall C, Asztalos E, Perlman K, Heon E. March
of Dimes (US$253,083 2004-2007)
TrialNet Clinical Center (Study group for prevention
of type 1 diabetes). Wherrett DK, Mahon J,
Daneman D. National Institutes of Health
(US$1,187,072 2001-2008)
Type 1 Diabetes Genetics Consortium. Wherrett
DK. Benaroya Research Institute (US$15,000
2004-ongoing)
MRI analyses of visuospatial processing deficits
in children born preterm or with congenital
hypothyroidism. Rovet J, McAndrews MP,
Desrocher M, Sheard E, Asztalos E. March of
Dimes (US$339,945 2007-2008)
Multiple courses of antenatal corticosteroids
for preterm birth study: A five-year follow-up
(MACS-5). Asztalos E, Rovet J. Canadian Institutes
of Health Research ($3,585,161 2005-2012)
National surveillance of non-type 1 diabetes
mellitus in Canadian children. Hamilton J, Dean H,
Amed S, Sellers E, Dannenbaum D, Laubscher T,
Booth G. Canadian Diabetes Association
($97,939 2006-2007)
Neuroimaging studies of hippocampal formation
in children with pre- and postnatal thyroid
hormone insufficiencies. Rovet J, Desrocher M,
McAndrews MP, Sheard E. Canadian Institutes of
Health Research ($728,640 2006-2011)
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
35
Gastroenterology, Hepatology and Nutrition
DIVISIONAL OVERVIEW
The Division of Gastroenterology, Hepatology and Nutrition is
recognized nationally and internationally for its contributions
to clinical care, research and education in the field of gastroenterology, including hepatology, nutrition and transplantation.
It is one of the only programs in North America offering a full
spectrum of paediatric �GI-coverage’ including clinical nutrition,
gastroenterology, hepatology and transplantation. The division
has a fully accredited three-year Royal College of Physicians and
Surgeons of Canada Fellowship training program with three to
four first-year fellows. Over the past year, four of our current
research fellows (out of a total of nine) are combining a formal
degree-granting program (MSc or PhD) with their research
fellowship years.
With the retirement this year of Dr. Eve Roberts, the division hosts
nine full-time staff, four part-time and two cross-appointed members.
The main clinical programs in the division include inflammatory
bowel disease, cystic fibrosis, luminal GI disorders, nutritional
disorders, liver diseases and liver and small bowel transplantation.
Our research spans the spectrum from basic and translational to
patient-based in such areas as inflammatory bowel disease,
pancreatic diseases, ulcer disease, liver diseases, GI microbiology
and immunology, nutritional metabolism and nutrient requirements.
This year, once again, fellows in the division have been honoured
with multiple awards, and fellowships. The staff members of the
division have published over 90 peer-reviewed publications,
25 books or book chapters and have received well over $5 million
of grant funding for projects spanning the next five years.
HONOURS AND AWARDS
Zlotkin S: International Ashoka Fellowship Award,
2007.
Zlotkin S: Canadian Institutes of Health Research
National Knowledge Translation Award, 2006.
Zlotkin S: Member of the Order of Canada, 2007.
Benchimol E: Travel Award from the First
International Gastrointestinal Eosinophil Research
Symposium.
Gana J: Presentation Award at the Digestive
Diseases Week of the American Gastroenterology
Association, 2007.
Guttman O: CASL/Schering Canada Fellowship
Award, 2007.
36
DEPARTMENT OF PAEDIATRICS
Muise A: Canadian Society for Clinical
Investigators (CSCI)/Canadian Institutes for
Health Research Award for Excellence in Resident
Research, 2007.
Muise A: Starr Medal for Outstanding Scholarship,
Post-Graduate Medical Education, Faculty of
Medicine, University of Toronto, 2006.
Muise A: Paediatric Research Award, Senior
Trainee – Basic Science, Department of
Paediatrics, The Hospital for Sick Children,
University of Toronto, 2007.
Muise A: Elizabeth Arbuthnot Dyson Fellowship:
Awarded upon Recommendation of the Chair
of Paediatrics The Hospital for Sick Children and
Joseph M. West Family Memorial Fund, Faculty
of Medicine, University of Toronto, 2006.
Muise A: Posdoctoral Fellow, Canadian Child
Health Clinician Scientist Program, Canadian
Institute Health Research – Strategic
Training Initiatives in Health Research Program
Award, 2006.
ANNUAL REPORT 2006-07
Turner D: American Physician Fellowship
Award, 2006.
Turner D: Postgraduate Research Award, Joseph
M. West Family Memorial Fund and the Chisholm
Memorial Fellowship, University of Toronto, 2006.
Turner D: Levy/Thompson Award for Outstanding
Oral Presentation, Canadian Digestive Disease
Week (CDDW)-GRIT, 2007.
Turner D: Canadian Institute Health Research/
Canadian Association of Gastroenterology/
Crohn’s Colitis Foundation of Canada (Canadian
Institutes of Health Research/CAG/CCFC)
Fellowship Award, 2006.
Turner D: American Gastroenterology Association
(AGA) Fellow Abstract Prize, 2007.
Turner D: CanMeds Competencies Award,
The Hospital for Sick Children, University of
Toronto, 2007.
Dr. Vicky Ng and GI team members
Pencharz P: University of Toronto, Department of
Paediatics, Physician Research Award for Career
Excellence, 2007.
Division Head
Dr. Stanley Zlotkin
Full-Time
Dr. Peter Durie
Dr. Nicola Jones
Dr. Anne-Marie Griffiths
Dr. Simon Ling
Dr. Vicky Ng
Dr. Paul Pencharz
Dr. Eve Roberts
Dr. Philip Sherman
Dr. Mary Zachos
Part-Time
Dr. Glenn Berall
Dr. Carol Durno
Dr. Paul Kortan
Dr. Margaret Marcon
Dr. Gary May
Dr. Mary Sherlock
Dr. Catharine Walsh
Cross-Appointed
Dr. Mary Corey
Research Fellows
Dr. Eric Benchimol
Dr. Juan Gana
Dr. Tanja Gonska
Dr. Aleixo Muise
Dr. Khalid Noli
Clinical Fellows
Dr. Orlee Guttman
Dr. Seamus Hussey
Dr. Dan Turner
Dr. Thomas Walters
Dr. Eytan Wine
Dr. Jason Yap
Subspecialty Residents
Dr. Ewurabena Simpson
Administrative Staff
Chona Callejo
Roxanne Francis
Margaret Johnson
Sherry Joy
Parasto Nejatie
Lilatool Shakur
Suzanne Shek
Turner D: Chisholm Memorial Fellowship, the
Elizabeth Arbuthnot Dayson Fellowship, the Nellie
L. Farthing Fellowship, the William S. Fenwick
Fellowship, the Miriam Neveren Memorial Award
and the Joseph M. West Family Memorial Fund
Research Award, 2007.
Wine E: Canadian Institute of Health Research/
Canadian Association of Gastroenterology/
Industry (Astra Zeneca) Research Initiative
Award, 2006.
Wine E: University of Toronto Faculty of Medicine,
Postgraduate Award, 2006.
PUBLICATIONS
Achkar JP, Dassopoulos T, Silverberg MS, Tuvlin
JA, Duerr RH, Brant SR, Siminovitch K, Reddy D,
Datta LW, Bayless TM, Zhang L, Barmada MM,
Rioux JD, Steinhart JH, McLeod RS, Griffiths AM,
Cohen Z, Yang H, Bromfield JP, Schumm P,
Hanauer SB, Cho JH, Nicolae D and the NIDDK
IBD Genetics Consortium: Phenotype-stratified
genetic linkage study demonstrates that IBD2 is
an extensive ulcerative colitis locus. American
Journal of Gastroenterol 2006: 101: pp 572-580.
Aspelund G, Ling SC, Ng V, Kim PCW: A role for
laparoscopic approach in the treatment of biliary
atresia and choledochal cysts. Journal of Pediatric
Surgery 2007: 42: pp 869-872.
Atkinson C, Morris SK, Ng V, Friedman JN: A child
with fever, hip pain and limp. Canadian Medical
Association Journal 2006: 174: pp 924.
Avitzur Y, Ngan BY, Lao M, Fecteau A, Ng VL:
Prospective evaluation of the prevalence and
clinical significance of positive autoantibodies
after pediatric liver transplantation. Journal of
Pediatric Gastroenterology and Nutrition 2007:
45: pp 222-227.
Ball RO, Courtney-Martin G, Pencharz PB:
The in vivo sparing effect of cysteine on
methionine requirements in animal models
and adult humans. Journal of Nutrition 2006:
136: pp 1682-1693.
38
DEPARTMENT OF PAEDIATRICS
Barron M, Doyle J, Zlotkin S: Vitamin K deficiency
in children pre-bone marrow transplantation. Bone
Marrow Transplantation 2006: 37: pp 151-154.
Beharry SA, Ackerely C, Corey M, Kent G, Heng YM, Christensen H, Luk C, Yantiss RK, Nasser IA,
Zaman M, Freedman SD, Durie PR: Long-term
docosahexaenoic acid therapy in a congenic
murine model of cystic fibrosis. American Journal
of Physiology – Gastrointestinal Liver Physiology
2007: 292: pp 839-848.
Bousvaros A, Antonioli D, Colletti R, Dubinsky M,
Glickman J, Gold B, Griffiths A, JEvon G, Higuchi L,
Hyams J, Kirschner B, Kugathasan S, Baldassano
R, Russo P: Differentiating ulcerative colitis from
Crohn’s disease in children and young adults:
A report of a working group of the North
American Society of Pediatric Gastroenterology
Hepatology and Nutrition, and the Crohn’s
and Colitis Foundation of America. Journal of
Pediatric Gastroenterology and Nutrition 2007:
44: pp 653-674.
Brunton J, Shoveller AK, Pencharz PB, Ball RO:
Identification of limiting amino acids in two
parenteral nutrition solutions by indicator amino
acid oxidation. Journal of Nutrition 2007: 137:
pp 1253-1259.
Cantin AM, Hanrahan JW, Bilodeau G, Ellis L,
Dupuis A, Liao J, Zielenski J, Durie P. Cystic
Fibrosis transmembrane conductance regulator
function is suppressed in cigarette smokers.
American Journal of Respiratory and Critical Care
Medicine 2006: 173: pp 1139-1144.
Clarke M, Berall G, Pencharz P, Locker D, Kenny
DJ: Malnourishment in a population of young
children with severe early childhood caries
attending a hospital dental clinic for oral
rehabilitation with general anesthesia. Pediatric
Dentistry 2006: 28: pp 254-259.
Cooper M, Ungar W, Zlotkin S. An assessment of
inter-rater agreement of the literature filtering
process in the development of evidence-based
dietary guidelines. Public Health Nutrition 2006:
9: pp 494-500.
ANNUAL REPORT 2006-07
Dasgupta R, Roberts E, Superina RA, Kim PC:
Effectiveness of Rex shunt in the treatment of
portal hypertension. Journal of Pediatric Surgery
2006: 41: pp 108-112.
Dassopoulos T, Nguyen GC, Sitton A, Bromfiled
GP, Schumm LP, Wu Y, Riguiero M, Siemanowski
B, Griffiths A, Brant S, Rious JD, Yang H, Duerr
RH, Silverberg M, Cho JH, Steinhart H:
Assessment of reliability and validity of BID
phenotyping within the NIDDK IBD Genetics
Consortium. Inflammatory Bowel Disease 2007:
13: pp 975-983.
De Pee S, Moench-Pfanner R, Martini E, Zlotkin S,
Darton-Hill I, Bloem MW: Home-fortification in
emergency response and transition programming:
Experiences in Aceh and Nias, Indonesia. Food
and Nutrition Bulletin 2007: 28: pp 189-197.
Diamond IR, Fecteau A, Millis JM, Losanoff JE,
Ng V, Anand R, Song C and the SPLIT Research
Group: Impact of graft type on outcome in
pediatric liver transplantation. Annals of Surgery
2007: 246: pp 301-310.
Diamond IR, de Silva N, Pencharz PB, Kim JH,
Wales PW: Neonatal short bowel syndrome
outcomes after the establishment of the first
Canadian multidisciplinary intestinal rehabilitation
program: preliminary experience. Journal of
Pediatric Surgery 2007: 42: pp 806-811.
Dosman C, Brian J, Drmic I, Senthilselvan A,
Harford M, Smith R, Sharieff W, Zlotkin S,
Moldofsky H, Roberts W: Children with autism:
Effect of iron supplementation on sleep and
ferritin. Pediatric Neurology 2007: 36: pp152-158.
Griffiths AM: Enteral feeding in inflammatory bowel
disease. Current Opinion in Clinical Nutrition and
Metabolic Care 2006: 9: pp 314-318.
Griffiths AM: Interventions for growth failure in
pediatric IBD. Journal of Pediatric Gastroenterology and Nutrition 2006: 43: pp S17-S18.
Hirve S, Bhave S, Bavdekar A, Naik S, Pandit A,
Schauer C, Christofides C, Hyder Z, Zlotkin S: Low
dose �Sprinkles’ – An innovative approach to treat
iron deficiency anemia in infants and young
children. Indian Pediatrics 2007: 44: pp 91-100.
Ho W, Cheretakis C, Durie P, Kulkarni G, Glogauer
M: Prevalence of oral diseases in ShwachmanDiamond syndrome. Special Care in Dentistry
2007: 27: pp 52-58.
Hsu JWC, Ball RO, Pencharz PB: Evidence that
phenylalanine may not provide the full needs for
aromatic amino acid needs in children. Pediatric
Research 2007: 61: pp 361-365.
Hyams J, Markowitz J, Lerer T, Griffiths AM, Mack
D, LeLeiko N, and the Pediatric IBD Registry:
The natural history of corticosteroid therapy for
ulcerative colitis in children. Clinical Gastroenterology and Hepatology 2006:4: pp 1118-1123.
Hyams JS, Crandall W, Kugathasan S, Griffiths
AM, Olson A, Baldassano R, and the REACH Study
Group: Induction and maintenance infliximab
therapy for the treatment of moderate-to-severe
Crohn’s disease in children. Gastroenterology
2007: 132: pp 863-873.
Hyder Z, Zlotkin S: Effect of daily versus once
weekly home fortification with sprinkles on
haematological and iron status among young
children in rural Bangladesh. Food and Nutrition
Bulletin 2007: 28: pp 156-164.
Jandu N, Shen S, Wickham M, Prajapati R, Finlay
B, Karmali M, Sherman P: Multiple seropathotypes of Verotoxin-producing Escherichia
coli disrupt interferon-gamma-induced tyrosine
phosphorylation of signal transducer and
activation of transcription-1. Microbial
Pathogenesis 2007: 42: pp 62-71.
Rioux JD, Xavier RX, Taylor KD, Silverberg MS,
Goyette P, Huett A, Green T, Kuballa P, Barmada
MM, Datta LW, Shugart YY, Griffiths AM, Targan
SR, Ippoliti AF, Bernard E-J, Mei L, Nicolae DL,
Regueiro M, Schumm LP, Steinhart AH, Rotter JI,
Duerr RJ, Cho JH, Daly MJ, Brant SR: Genomewide association study identifies new susceptibility
loci for Crohn’s disease and implicates autophagy
in disease pathogenesis. Nature Genetics 2007:
39: pp 596-604.
Johnson-Henry K, Hagen K, Gordonpour M,
Tompkins T, Sherman P: Surface-layer protein
extracts from Lactobacillus helveticus inhibit
enterohaemorrhagic Escherichia coli O157:H7
adhesion to epithelial cells. Cellular Microbiology
2007: 9: pp 356-367.
Kalnins D, Durie P, Pencharz P: Nutritional
management of Cystic Fibrosis patients. Current
Opinion in Clinical Nutrition and Metabolic Care
2007: 10: pp 348-354.
Kalnins D, Ellis L, Corey M, Pencharz PB, Stewart
C, Tullis E, Durie, PR: Enteric-coated pancreatic
enzyme with bicarbonate is equal to standard
enteric-coated enzyme in treating malabsorption
in cystic fibrosis. Journal of Pediatric Gastroenterology and Nutrition 2006: 42: pp 256-261.
Kappelman M, Bousvaros A, Hyams J, Markowitz
J, Griffiths AM, and the Pediatric IBD Registry
Group: Variation in the initial management of
children with Crohn’s disease. Inflammatory Bowel
Disease 2007: 13: pp 890-895.
Khan E, Hyder SMZ, Tondeur MC, Raza S, Khan
NA, Zlotkin S: Home fortification with sprinkles to
reduce childhood anaemia: Lessons learned in
North West Frontier Province, Pakistan. Pakistan
Journal of Medical Research 2006: 45: pp 35-40.
Khurana R, Fishbach L, Chiba N, Van Zanten S,
Sherman P, George B, Goodman K, Gold B: Metaanalysis: Helicobacter pylori eradication treatment
efficacy in children. Alimentary Pharmacology and
Therapeutics 2007: 25: pp 523-536.
Kirsch R, Bokhary R, Marcon MA, Cutz E:
Activated mucosal mast cells differentiate
eosinophilic (allergic) esophagitis from
gastroesophageal reflux disease. Journal of
Pediatric Gastroenterology and Nutrition 2007:
44: pp 20-26.
Kulkarni PP, She Y-M, Smith SD, Roberts EA,
Sarkar B: Proteomics of metal-transport and
metal-associated diseases. Chemistry 2006: 12:
pp 2410-2422.
Law GK, Bertolo RF, Adiri-Awere A, Pencharz PB,
Ball RO: Adequate oral threonine is critical for
mucin production and gut function in neonatal
piglets. American Journal of Physiology 2007:
292: pp G1293-G1301.
Mack D, Griffiths AM, Markowitz J, Bousvaros A,
Rosh J, Mezoff A, Moyer S, Keljo D, Hyams JS for
the Pediatric IBD Registry: 2006-1865.R2
laboratory values of children newly diagnosed with
Inflammatory Bowel Disease. Pediatrics 2007:
119: pp 1113-1119.
Mager D, McGee P, Furuya KN, Roberts EA:
Prevalence of vitamin K deficiency in children with
chronic liver disease. Journal of Pediatric Gastroenterology and Nutrition 2006: 42: pp 71-76.
Mager D, Roberts EA: Nonalcoholic fatty liver
disease in children. Clinics in Liver Disease 2006:
10: pp 109-131.
Mager DR, Wykes LJ, Roberts EA, Ball RO,
Pencharz PB: Effect of orthotopic liver
transplantation on branched chain amino acid
requirement in children. Pediatric Research 2006:
59: pp 829-834.
Mager DR, Wykes LJ, Roberts EA, Ball RO,
Pencharz PB: Leucine oxidation in children with
mild to moderate chronic cholestatic liver disease.
Journal of Nutrition 2006: 136: pp 965-70.
Markowitz J, Hyams J, Mack D, LeLeiko N, Griffiths
AM, and the Pediatric IBD Registry: Corticosteroid
therapy in the age of infliximab: acute and
1 year outcomes in newly diagnosed children
with Crohn’s disease. Clinical Gastroenterology
and Hepatology 2006: 4: pp 1124-1129.
Muise AM, Turner D, Kim P, Marcon M, Ling SCL:
Biliary atresia associated with choledochal cyst:
implications for classification. Clinical Gastroenterology and Hepatology 2006: 4: pp 1411-1414.
Muise AM, Walters TD, Wine E, Griffiths AM,
Turner D, Duerr RH, Regueiro MD, Ngan BY, Xu W,
Sherman PM, Silverberg MS, Rotin D: Protein
Tyrosine Phosphatase Sigma is associated
with ulcerative colitis. Current Biology 2007: 17:
pp 1212-1218.
Nicholas DB, Munk M, Otley A, Avolio J, Griffiths
AM: Challenges and strategies of children and
adolescents with Inflammatory Bowel Disease:
A qualitative examination. Health and Quality of
Life Outcomes 2007: 5: p 28.
Norton SP, Jacobson K, Moroz SP, Culham G,
Ng V, Turner J, John P: The congenital intrahepatic
arterioportal fistula syndrome: elucidation
and proposed classification. Journal of Pediatric
Gastroenterology and Nutrition 2006: 43:
pp 248-255.
Nguyen GC, Torres EA, Regueiro M, Bitton A,
Dassopoulos T, Griffiths AM, Hanauer SB, Kane SV,
Lahaie R, Oliva-Hemker M, Pare P, Wild GE, Rioux
JD, Yang H, Duerr RH, Cho JH, Steinhart AH,
Brant SR, Silverberg MS: Inflammatory Bowel
Disease characteristics among African Americans,
Hispanics, and non-Hispanic Whites: Characterization of a large North American cohort. American
Journal of Gastroenterology 2006: 101:
pp 1012-1023.
O’Shea A-M, Wilson G, Ling SC, Minassian B, Cutz
E: Lafora-like ground glass inclusions in
hepatocytes of paediatric patients – Report of two
cases. Pediatric and Developmental Pathology
March 22, 2007 [Epub ahead of print].
Otley AR, Griffiths AM, Kugathasan S, Pfefferkorn
M, Mezoff A, Rosh J, Tolia V, Markowitz J, Mack D,
Oliva-Hemker M, Wyllie R, Rothbaum, Bousvaros
A, Hyams JS: Health-related quality of life in the
first year following a diagnosis of pediatric
inflammatory bowel disease. Inflammatory Bowel
Disease 2006: 12: pp 684-691.
Pencharz PB: Drug dosing in children – Special
considerations. Haemophilia 2006: 12: pp 30-32.
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
39
Roberts EA, Yap J: Nonalcoholic fatty liver disease
(NAFLD): Approach in the adolescent patient.
Current Treatment Options in Gastroenterology
2006: 9: pp 423-431.
Roberts EA: Nonalcoholic steatohepatitis (NASH)
in children. Clinics in Liver Disease 2007: 11:
pp 155-172.
Roberts EA: Pediatric NAFLD – A “growing”
problem? Journal of Hepatology 2007: 46:
pp 1133-1142.
Schibli S, Corey M, Gaskin KJ, Ellis L, Durie PR:
Towards the ideal quantitative pancreatic function
test: Analysis of test variables that influence
validity. Clinical Gastroenterology and Hepatology
2006: 4: pp 90-97.
Sharieff W, Horton SE, Zlotkin S: Economic gains
of a home fortification program: Evaluation of
“Sprinkles” from the provider’s perspective.
Canadian Journal of Public Health 2006: 97:
pp 20-23.
Sharieff W, Yin S, Wu M, Yang Q, Schauer C,
Tomlinson G, Zlotkin S: Daily or weekly administration of micronutrient sprinkles in school has high
compliance and does not cause iron overload in
Chinese children: A cluster-randomized trial.
Public Health Nutrition 2006: 9: pp 336-344.
Sharieff W, Zlotkin S, Tondeur M, Feldman B,
Tomlinson G. Physiologic mechanisms can predict
hematologic responses to iron supplements in
growing children: a computer simulation model.
American Journal of Clinical Nutrition 2006: 83:
pp 681-687.
Soon G, Saunders N, Ipp M, Sherman P,
Macarthur C: Community-based case-control study
of childhood chronic abdominal pain: role of
selected laboratory investigations. Journal of
Pediatric Gastroenterology and Nutrition 2007:
44: pp 524-526.
Squires RH, Shneider BL, Bucuvalas B, Alonso E,
Sokol RJ, Narkewicz M, Dhawan A, Rosenthal P,
Rodriguez-Baez N, Murray KF, Horslen S, Martin
MG, Lopez MJ, Soriano H, McGuire BM, Jonas M,
Yazigi N, Shepherd RW, Schwarz K, Lobritto S,
Thomas DW, Lavine JE, Karpen S, Ng V, Kelly D,
Simonds N, Hynan LS: Acute liver failure in
children: The first 348 patients in the pediatric
acute liver failure (PALF) study group. Journal of
Pediatrics 2006: 148: pp 652-658.
Sweezey NB, Smith D, Corey M, Ellis L, Carpenter
S, Tullis DE, Durie P, O’Brodovich H: Amilorideinsensitive nasal potential difference varies with
the menstrual cycle in cystic fibrosis. Pediatric
Pulmonology 2007: 42: pp 519-524.
Sylvester FA, Wyzka N, Hyams JS, Lerer T, Vance
K, Hawker G, Griffiths AM: natural history of bone
metabolism and bone mineral density in children
with Inflammatory Bowel Disease. Inflammatory
Bowel Disease 2007: 13: pp 42-50.
Terebiznik MR, Vazquez CL, Banks D, Colombo MI,
Jones NL: Helicobacter pylori VacA toxin
promotes bacterial intracellular survival in gastric
epithelial cells. Infection and Immunity 2006: 74:
pp 6599-6614.
Turner D, Otley AR, de Bruijne J, Mack D, Uusoue
K, Walters T, Zachos M, Mamula P, Hyams J,
Griffiths AM: Development and validation of
a pediatric ulcerative colitis activity index.
A prospective multicenter study. Gastroenterology
2007: 133: pp 423-432.
Turner D, Schreiber R, Grant D, Hebert D, Sherman
P: Hemolytic uremic syndrome after pediatric liver
transplantation. Journal of Pediatric Gastroenterology and Nutrition 2006: 43: pp 109-112.
Shneider B, GonzГЎlez-Peralta R, Roberts EA:
Controversies in management pediatric liver
disease: hepatitis B, C and NAFLD: Summary
of single topic conference. Hepatology 2006:44:
pp 1344-1354.
Turner D, Walsh C, Steinhart AH, Griffiths AM:
Response to corticosteroids in severe ulcerative
colitis: a systematic review of the literature
and a meta-regression. Clinical Gastroenterology
and Hepatology 2007: 5: pp 103-110.
Skinn A, Vergnolle N, Cellars L, Sherman P,
MacNaughton W: Combined challenge of mice
with Citrobacter rodentium and ionizing radiation
promotes bacterial translocation. International
Journal of Radiation Biology 2007: 83:
pp 375-382.
Turner D, Zlotkin SH, Shah P, Griffiths A: Omega 3
Fatty Acids (fish oil) for Maintenance of Remission
in Crohn’s Disease. Cochrane Database of
Systematic Reviews 2007: 2: pp 1469-1493.
Skinn A, Vergnolle N, Zamuner S, Wallace J,
Cellar L, MacNaughton W, Sherman P: Citrobacter
rodentium causes iNOS-independent intestinal
epithelial dysfunction in mice. Canadian Journal
of Physiology and Pharmacology 2006: 84:
pp 1301-1312.
40
DEPARTMENT OF PAEDIATRICS
Urschel KL, Evans AR, Pencharz PB, Ball RO:
Infusion of glucagon-like peptide 2 with an
arginine deficient diet increases endogenous
arginine synthesis from proline in parenterallyfed neonatal piglets. Livestock Science 2007:
108: pp 41-44.
ANNUAL REPORT 2006-07
Urschel KL, Evans AR, Wilkinson CW, Pencharz PB,
Ball RO: Parenterally-fed neonatal piglets have
a low level of endogenous arginine synthesis from
circulating proline. Journal of Nutrition 2007: 137:
pp 601-606.
Urschel KL, Pencharz PB, Ball RO: Ornithine
metabolism, but not arginine synthesis, is
affected by the addition of ornithine to an
arginine-deficient diet in enterally-fed piglets.
Livestock Science 2007:108: pp 137-141.
Urschel KL, Shoveller AK, Uwiera RRE, Pencharz
PB, Ball RO: Citrulline is an effective arginine
precursor in enterally-fed neonatal piglets. Journal
of Nutrition 2006: 136: pp 1806-1813.
Urschel KL, Wilkinson CW, Pencharz PB, Ball RO:
Coadministration of ornithine alpha-ketoglutarate
is no more effective than ornithine as an arginine
precursor in piglets enterally fed an argininedeficient diet. Journal of Nutrition 2007: 137:
pp 55-62.
Vogt JA, Ishii-Schrade KB, Pencharz PB, Jones
PJH, Wolever TMS: L-rhamnose and lactulose
decrease serum triacylglycerols and their rate of
synthesis, but do not affect serum cholesterol
concentration in men. Journal of Nutrition 2006:
136: pp 2160-2166.
Walters TD, Gilman AR, Griffiths AM: Linear
growth improves during infliximab therapy in
children with chronically active severe Crohn’s
disease. Inflammatory Bowel Disease 2007: 13:
pp 424-430.
Wilschanski M, Dupuis A, Ellis L, Jarvi K, Zielenski
J, Tullis E, Martin S, Corey M, Tsui L-C, Durie P:
Mutations in the cystic fibrosis transmembrane
regulator gene and in vivo transepithelial
potentials. American Journal of Respiratory and
Critical Care Medicine 2006: 174: pp 787-794.
Yea C, Bukh J, Ayers M, Roberts E, Krajden M,
Tellier R: Monitoring of HCV quasispecies in
chronic infection by MALDI-TOF mass spectrometry
mutation detection. Journal of Clinical
Microbiology 2007: 45: pp 1053-1057.
Zachos M, Tondeur M, Griffiths AM: Enteral
nutritional therapy for inducing remission in
Crohn’s disease. Cochrane Database of
Systematic Reviews 2007: 24: CD000542.
Zareie M, Johnson-Henry K, Jury J, Yang P, Ngan B,
McKay D, Soderholm J, Perdue M, Sherman P:
Probiotics prevent bacterial translocation and
improve intestinal barrier function in rats following
chronic psychological stress. Gut 2006: 55:
pp 1553-1560.
Zlotkin S: Priorities in Nutritional Rehabilitation.
Editorial. Journal of Pediatric Gastroenterology
and Nutrition 2006: 43: pp S66-S71.
Dr. Eve Roberts
Duerr RH, Taylor KD, Brant SR, Rioux JD,
Silverberg MS, Daly MJ, Steinhart AH, Abraham C,
Regueiro M, Griffiths AM, Dassopoulos T, Bitton A,
Yang H, Targan S, Datta LW, Kistner EP, Schumm
LP, Lee A, Gregersen PK, Barmada MM, Rotter JI,
Nicolae DL, Cho JH: A genome-wide association
study identifies IL23R as an Inflammatory Bowel
Disease gene. Science 2006: 314: pp 1461-1463.
Zlotkin S: A critical assessment of upper intake
levels for Infants and Children. Journal of Nutrition
2006: 36: pp 1S-5S.
Zlotkin SH, Schauer S, Owusu-Agyie S, Wolfson J,
Tondeur MC, Asante KP, Newton S, Serfass RE,
Sharieff W: Demonstrating zinc and iron
bioavailability from intrinsically labeled
microencapsulated ferrous fumarate and zinc
gluconate sprinkles in young children. Journal of
Nutrition 2006: 136: pp 920-925.
BOOKS AND BOOK CHAPTERS
Ahmed NN, Durie PR: Nonpulmonary
manifestations of Cystic Fibrosis. In: Kendig’s
Disorders of the Respiratory Tract in Children, 7th
Edition (Chernick V, Boat TF, Wilmott RW, Bush A,
eds). Saunders Elsevier, Philadelphia, 2006.
Chan V, Sherman P, Bourke B: Evolution and
origin of virulence isolates. In: Bacterial Genomes
and Infectious Diseases (Chan V, Sherman P,
Bourke B, eds). Humana Press, Totowa, NJ, 2006.
Chan V, Sherman P, Bourke B: Genomic approach
to understanding infectious diseases mechanisms.
In: Bacterial Genomes and Infectious Diseases
(Chan V, Sherman P, Bourke B, eds). Humana
Press, Totowa, NJ, 2006.
Cox DW, Roberts EA: Wilson disease. In:
Gastrointestinal and Liver Disease (Feldman M,
Scharschmidt BF, Sleisenger MH, eds). SaundersElsevier, Philadelphia, 2006.
Griffiths AM: Nutrition and inflammatory bowel
disease. In: Modern Nutrition in Health and
Disease, 10th Edition (Shils ME, ed). Lipincott,
Williams & Wilkinson, Baltimore, 2006.
Mager D, Pencharz PB: Nutritional considerations
in children with developmental disabilities.
In: A Comprehensive Guide to Intellectual and
Developmental Disabilities (Brown I, Percy M,
eds). Brookes Publishing Company, Baltimore,
2007.
Ng VL: Laboratory assessment of liver function
and injury. In: Liver Disease in Children, 3rd
Edition. (Suchy FJ, Sokol RJ, Balistreri WF, eds).
Cambridge University Press, New York 2007.
Ng VL: Neonatal hepatitis. In: Pediatric
Gastrointestinal and Liver Disease, 3rd edition,
(Wyllie R, Hyams JS, eds). Elsevier, Amsterdam,
2006.
Pencharz PB, Ball RO: Amino acid requirements of
infants and children. In: Nestle Nutrition Workshop
Series, Volume 58 (Rigo J, Ziegler EE, eds).
Karger, Switzerland, 2006.
Pencharz PB, Young VR: Protein and amino acids.
In: Present Knowledge in Nutrition, 9th Edition
(Bowman BA, Russell RM, eds). ILSI Press,
Washington, 2006.
Portmann B, Roberts EA: Developmental
abnormalities and liver disease in childhood.
In: MacSween’s Pathology of the Liver, 5th Edition
(Burt A, Portmann B, Ishak K, Ferrell LD, eds).
Elsevier, Edinburgh, 2007.
Portmann B, Thompson RJ, Roberts EA, Paterson
AC: Genetic-metabolic disorders and the liver.
In: MacSween’s Pathology of the Liver, 5th edition
(Burt A, Portmann B, Ishak K, Ferrell LD, eds).
Elsevier, Edinburgh, 2007.
Roberts EA, Cox DW: Wilson’s disease.
In: Hepatology (Boyer T, Manns M, Wright T, eds).
Elsevier, Philadelphia, 2006.
Roberts EA: Drug-induced liver disease. In: Liver
Disease in Children, 3rd Edition (Suchy FJ, Sokol
RJ, Balistreri WF, eds). Cambridge University
Press, New York, 2007.
Roberts EA: NASH in children. In: Nonalcoholic
Steatohepatitis (Bataller R, ed). Permanyer,
Barcelona, 2007.
FUNDING
A longterm multicenter open-label follow-up study
of safety of infliximab as maintenance
therapy of paediatric Crohn’s disease. Griffiths
AM. Centocor, Inc. ($10,000/year 2003-2008)
A multi-centre study of the safety and efficacy
of N-acetylcysteine in the treatment of acute liver
failure in paediatric patients not caused by
acetaminophen. Ng VL, Fecteau A. National
Institutes of Health/National Institute of Diabetes
and Digestive and Kidney Diseases (US$69,000
2005-2010)
A novel candidate susceptibility gene at the IBD6
locus, Rotin D, Griffiths A. Crohn’s and Colitis
Foundation of Canada Innovations Grant.
($50,000 2007)
Arginine and CF. Grasemann H, Ratjen F, Pencharz
P. Canadian Cystic Fibrosis Foundation
($140,000 2007-2010)
Assessment of activity and prediction of outcome
in paediatric ulcerative colitis. Turner D, Steinhart
H, Griffiths A. Canadian Association of
Gastroenterology/Canadian Institutes of Health
Research ($65,000/year 2006-2008)
Cell signalling in mucosal inflammation and pain.
Ellen R, Sherman P. Canadian Institutes for
Health Research ($300,000/year 2002-2008)
Roberts EA: Wilson’s disease. In: Medicine (Liver
II) (Chapman R, Gilmore I, eds). Oxford, UK, 2007.
Cell signals: Cell signaling in mucosal
inflammation and pain. Ellen R, Jones N.
Canadian Institutes of Health Research
($300,000 2002-2008)
Secker D, Zlotkin S: Infant feeding. In: Essentials
of Human Nutrition, 3rd Edition (Mann J,
Stewart T, eds) Oxford University Press, Inc.,
New York, 2006.
Centre for the study of complex childhood
diseases. Post M, Henkelman M, Ratjen F, Snead
C, Pencharz P. Canadian Foundation for
Innovation ($8,228,769 2006)
Sherman P, Bourke B, Chan V: Future directions
of infectious disease research. In: Bacterial
Genomes and Infectious Diseases (Chan V,
Sherman P, Bourke B, eds). Humana Press,
Totowa, NJ, 2006.
Clinical research facilitation award: Understanding
CFTR folding, trafficking and membrane stability
and applying this knowledge towards development
of drug discovery assays. Durie PR. Cystic Fibrosis
Foundation Therapeutics, Inc. (US$108,280 2007)
Sonies BC, Marcon MA Imundo I: Swallowing
and other digestive problems. In: Myositis and
Me: A Complete Family Guide to Juvenile
Dermatomyositis and Other Inflammatory
Myopathies. Myositis Association of America,
Washington, 2006.
Clinician scientist training program in clinical
nutrition research. Pencharz P. Canadian Institutes
of Health Research ($265,000 2002-2008)
Walters TR, Griffiths AM: Growth failure in
childhood IBD. In: Challenges in IBD, 2nd Edition
(Jewell D, Mortensen N, Steinhart H, Pemberton J,
Warren B, eds). Blackwell Publishing Ltd., Oxford,
UK, 2006
Zlotkin S, Tondeur MC: Successful approachessprinkles. In: Nutritional Anemia, 1st Edition
(Kraemer K, Zimmermann M, eds) Sight and Life
Press, Switzerland, 2007.
Comparative pathogenesis and public health
significance of Verotoxin-producing E. coli
serotypes. Karmali M, Sherman P. Canadian
Institutes of Health Research Safe Food and
Water Initiative ($897,000 2003-2006)
Determining the threshold of CFTR function that
causes CF disease. Durie PR. Canadian Cystic
Fibrosis Foundation ($110,000/year 2005-2008)
Development and validation of a disease-specific
health-related quality of life questionnaire
for children after liver transplantation. Otley AR,
Ng VL, Nicholas DB, Thompson J, Gilmour S,
Watters C. Canadian Institutes of Health
Research (US $280,576 2005-2008)
Immune regulation and biomarker development
in paediatric and adult onset human autoimmune
diseases. Bar-Or A, Banwell B, Piccirillo CA,
Polychronakos C, Sherman P. Canadian Institutes
of Health Research Team Grant ($2,018,445
2007-2112)
Development of a novel microfluidic biochip
system for the detection of pathogenic bacteria.
Liu D, Sherman P. National Science and
Engineering Research Council of Canada
($362,260 2003-2006)
Innovative strategies for optimizing management
of infants with biliary atresia. Guttman O (CoSupervisor: Roberts EA) Canadian Association for
the study of Liver Diseasse/Canadian Institutes
of Health Research/Industry Fellowship ($55,000
2007-2008)
Disordered hepatocellular cu handling in the Tx-J
mouse, a model of Wilson Disease. Roberts EA.
Canadian Institutes of Health Research ($73,640
2004-2007)
Epidemiology of eosinophilic esophagitis in
children and adolescents in Canada. Marcon, MA,
Dourin EJ. Campbell Fund ($62,966 2006-2008)
Food intake control in children. Anderson GH,
Berall GB, Goode RC, Pencharz PB. Canadian
Institutes of Health Research ($104,219
2007-2010)
Functional outcomes after paediatric liver
transplantation. Ng VL, Fecteau A. National
Institutes of Health/NIDDK (US$6,000
2005-2007)
Hepatocellular mitochondrial function in a novel
murine model of Wilson Disease. Sarkar B,
Roberts EA. Canadian Liver Foundation ($59,986
2004-2006)
Homocysteine clearance by hemodialysis. Darling
P, Goldstein M, McFarlane P, Pencharz P. Kidney
Foundation ($28,350 2006)
Host epithelial cell responses to attaching-effacing
gastrointestinal pathogens. Sherman P.
Canadian Institutes of Health Research
($679,517 2002-2007)
Host immune response to Helicobacter pylori
infection. Jones NL. Canadian Institute of Health
Research ($311,073 2004-2007)
IBD research database support. Griffiths AM.
Schering Canada ($20,000/year 2005-ongoing)
Identification of IBD susceptibility genes.
Silverberg M, Siminovitch K, Steinhart H, Griffiths
AM, Cohen Z. National Institutes of
Health/National Institute of Diabetes and
Digestive and Kidney Diseases ($38,000/year
2002-2007)
International collaboration project. Zlotkin S.
Canadian Institutes of Health Research ($25,000
2006-2006)
International opportunities program
development/planning. Zlotkin S. Canadian
Institutes of Health Research ($25,000
2007-2008)
Predictors of response to intravenous
corticosteroids therapy in paediatric patients with
severe ulcerative colitis: A multi-center study.
Griffiths AM. Schering Canada ($150,000 2007)
Role of probiotics in the management of
experimental inflammatory bowel disease.
Sherman PM. Crohn’s and Colitis Foundation of
Canada “Fay Shapiro Cutler Grant-In-Aid
Research” ($375,000 2007-2010)
SBDS protein expression in peripheral blood
leukocytes. Durie PR, Rommens JM, Shimamura
A. Shwachman Diamond Syndrome Foundation
(US$30,000 2006-2007)
Sprinkles project support. Zlotkin S. HJ Heinz
Company Foundation ($600,000 2006-2007)
Investigation of Helicobater pylori survival in host
cells. Jones NL. Early Researcher Award, Ontario
Ministry of Research and Innovation ($150,000
2006-2011)
Knowledge translation award. Zlotkin S. Canadian
Institutes of Health Research ($100,000
2006-2007)
Molecular genetics, SBDS function and deficiency
in SDS. Rommens JM, Durie PR. National
Institutes of Health ($1,250,000 2004-2009)
Molecular mechanisms associated with H. pylori
survival in macrophages. Jones NL. Canadian
Association of Gastroenterology/Canadian
Institutes of Health Research ($60,000
2004-2006)
Multi-site trial of azathioprine dosing in Crohn’s
disease. Griffiths A, Hanauer S. National
Institutes of Health/National Institute of Diabetes
and Digestive and Kidney Diseases ($20,000 per
2005-2007)
Neonatal protein and energy metabolism.
Pencharz P. Medical Research Council/Canadian
Institutes of Health Research ($90,470 2005 and
$136,817 2006-2011)
NOD2/CARD15 genotypes in the prediction of
time to post-operative recurrence following
resection for ileal Crohn’s disease. Walters T,
Griffiths AM, Silverberg M. Canadian
Association of Gastroenterology/Canadian
Institutes of Health Research ($65,000/year
2005-2007)
Pico-Salax versus Poly-Ethylene Glycol for bowel
cleanout before colonoscopy in children – A single
blinded randomized controlled trial. Ling SC.
Ferring Inc. ($24,000 2006-2007)
Studies of paediatric liver transplantation (SPLIT).
Ng V, Fecteau A. National Institutes of Health/
National Institute of Diabetes and Digestive and
Kidney Diseases (US$75,000 2005-2010)
Studies of primary sclerosing cholangitis
“STOPSC”. Ling SC. The Morgan Foundation
($2,500 2006-2007)
Targeted small molecule therapies for Cystic
Fibrosis. Bear CE, Deber CM, Durie PR, Lingwood
C, Rotin D, Ratjen F, Yeger H. Canadian Cystic
Fibrosis Foundation – BREATHE Program
($480,000/year 2004-2009)
The contribution of genetic modulators of disease
severity in cystic fibrosis to other diseases
with similarities of clinical phenotype. Durie PR,
Zielenski J. Genome Canada ($5,787,662
2005-2009)
The long-term effect of ALL and its treatment
on bone mineralization. Pencharz P. Paediatric
Oncology Group of Ontario ($30,310 2006)
The use of indicator amino acid oxidation to
determine amino acid requirement. Pencharz P,
Ball R. Medical Research Council/Canadian
Institutes of Health Research ($152,967
2005-2010)
Therapeutic interventions for paediatric nonalcoholic fatty liver disease (NAFLD) Yap J.
(Co-supervisor: Roberts EA) Canadian Institutes
of Health Research/Strategic Training Initiative
in Health Research ($40,000 2006-2008)
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
43
Division Head
Dr. Victor Blanchette
Full-Time
Dr. Oussama Abla
Dr. Ute Bartels
Dr. Sylvain Baruchel
Dr. Eric Bouffet
Dr. Leonardo BrandГЈo
Dr. Michael Capra
Dr. Manuel Carcao
Dr. Helen Chan
Dr. John Doyle
Dr. Yigal Dror
Dr. Adam Gassas
Dr. Ron Grant
Dr. Abha Gupta
Dr. Hans Hitzler
Dr. Annie Huang
Dr. Meredith Irwin
Dr. Walter Kahr
Dr. Melanie Kirby
Dr. David Malkin
Dr. Ahmed Naqvi
Dr. Paul Nathan
Dr. Isaac Odame
Dr. Lillian Sung
Dr. Uri Tabori
Dr. Sheila Weitzman
Dr. Suzan Williams
Cross-Appointed/
Part-Time
Dr. Sean Bulley
Dr. Anthony Chan
Dr. Stephen Comay
Dr. Lee Ann Gallant
Dr. Mark Greenberg
Dr. David Hodgson
Dr. Nicole Inch
Dr. Normand Laperriere
Dr. Barbara-Ann Millar
Dr. Aubrey Maze
Dr. Fred Saunders
Dr. Ben Saxon
Dr. Jill Solomon
Haematology/Oncology
DIVISIONAL OVERVIEW
Dr. Abha Gupta
The Division of Haematology/Oncology provides a diagnostic
service and specialist care for children <18 years of age with
cancer (paediatric oncology), non-malignant blood disorders
(paediatric hematology) and haematopoietic stem cell (blood and
marrow) transplantation. The division is the largest of its kind in
Canada and among the largest of such programs worldwide.
Approximately 300 new cancer cases are registered in the
oncology program each year, and The Hospital for Sick Children is
the designated site for haematopoietic stem cell transplantation
for patients <18 years of age in the Province of Ontario.
Dr. Gupta holds a cross-appointment in the Department of Medical
Oncology at the Princess Margaret Hospital where she will pursue her
career interest in sarcomas and bone tumours in adolescents and
young adults.
Reflecting the size and diversity of its clinical services, the division
is functionally organized into six sections and three programs: the
leukaemia/lymphoma section (Section Head, Dr. Sheila Weitzman);
the neurooncology (brain tumour) section (Section Head, Dr. Eric
Bouffet); the solid tumour section (Section Head, Dr. Ron Grant);
the blood and marrow transplantation section (Section Head, Dr.
John Doyle); the haematology section (Section Head, Dr. Victor
Blanchette); the inpatient services section (Section Head, Dr.
Ahmed Naqvi); the aftercare (long-term follow up) program (Program
Head, Dr. Mark Greenberg); the new agents and experimental
therapies program (Program Head, Dr. Sylvain Baruchel); and the
cancer genetics program (Program Co-Heads, Drs. David Malkin
and Rosanna Weksberg). The haematology section has welldefined large programs in paediatric thrombosis and haemostasis,
the paediatric haemoglobinopathies and the paediatric marrow
failure syndromes. The division is an active member of the
Children’s Oncology Group (COG), the largest paediatric clinical
trials group in North America (SickKids Principal Investigator, Dr.
David Malkin), and is committed to the improvement in outcomes
of children with cancer through participation in ethics approved,
prospective clinical trials. The division is a member of the
paediatric oncology phase I Consortium of COG (Principal
Investigator, Dr. Sylvain Baruchel), and is an active participant in
activities of the Société Internationale d’Oncologie Pédiatrique
(SIOP), the Histiocyte Society and the Berlin Frankfurt Munster
(BFM) paediatric leukaemia clinical trials group.
The division is the largest Royal College of Physicians and Surgeons
of Canada accredited training program for the specialty paediatric
haematology/oncology in Canada (Training Program Director, Dr.
Ahmed Naqvi). The education program in the division also includes
a very large international training program in paediatric haematology/
oncology and offers subspecialty training opportunities in areas
such as paediatric neurooncology, cancer genetics, blood and
marrow transplant and paediatric haemostasis. Research in the
division spans clinical to basic science with a special focus on
translational research. Currently, 14 of the division’s 27 full-time
faculty have appointments as clinician-scientists or clinicianinvestigators in the Department of Paediatrics with parallel
appointments in the Research Institute. Foci of research include
studies in the paediatric leukaemias (Dr. Hans Hitzler), solid
tumours (Dr. Meredith Irwin), brain tumors (Drs. Annie Huang,
Uri Tabori), retinoblastoma (Dr. Helen Chan), neuroblastoma
(Drs. Meredith Irwin, David Kaplan, Sylvain Baruchel), genetics of
childhood cancer (Dr. David Malkin), supportive care of children
with cancer (Dr. Lillian Sung), adverse effects in survivors of
childhood cancer (Drs. Mark Greenberg, Paul Nathan), experimental
cancer therapies and angiogenesis (Dr. Sylvain Baruchel), paediatric
haemoglobinopathies (Drs. Isaac Odame, Melanie Kirby), paediatric
marrow failure syndromes (Dr. Yigal Dror), platelet granule biology
(Dr. Walter Kahr), the inherited and acquired bleeding disorders
of childhood including the haemophilias (Drs. Victor Blanchette,
Manuel Carcao) and paediatric thrombosis (Drs. Leo Brandao,
Suzan Williams). Research in the Division is multidisciplinary,
including health care professionals with relevant expertise from a
variety of areas (e.g., nursing, pharmacy, psychology, social work).
The division is committed to facilitating knowledge exchange
through international partnerships with a particular focus on
countries lacking the health care resources available in Canada.
During the past year two full-time physicians were added to the
division: Dr. Isaac Odame and Dr. Abha Gupta. Dr. Odame was
appointed as Co-Director of the Division’s Haemoglobinopathy
Program and Dr. Gupta joins the solid tumour section in the division.
The administrative team for the division includes Dr. Victor
Blanchette (Division Chief), Dr. Sheila Weitzman (Associate Director,
Clinical), Judy Van Clieaf (Director, Child Health Services) and
Lucy Holford (Team Leader, Administrative and Support Services).
Clinical and
Research Fellows
Dr. S. Abdullah
Dr. I. Abosoudah
Dr. S. Afzal
Dr. T. Al-Asaad
Dr. A. Al-Rawas
Dr. M. Al-Shahrani
Dr. A. Al-Yamani
Dr. A. Al-Zahrani
Dr. M. Alharbi
Dr. M. Ali
Dr. S. Bartakke
Dr. T. Biss
Dr. E. Blanco
Dr. V. Breakey
Dr. M. Cada
Dr. T. Finkelstein-Schechter
Dr. A. Gupta
Dr. M. Ishaqi
Dr. L. Lau
Dr. A. Lee Chong
Dr. J. Moppett
Dr. B. Pongtanakul
Dr. M. Rojas
Dr. K. Scheinemann
Dr. C. Segbefia
Dr. C. Traivaree
Dr. T. Truong
Dr. B. Williams
Dr. P. Wong
Dr. M. Zolaly
Administrative Staff
Bibi Ali
Ingrid Argiropoulos
Barbara Black
Sandra Carbone-Walker
Carol Ellis
Connie Grillo
Lucy Holford
Shanaz Karim
Philippa McCaffrey
Christal Malcolm
Sylvia Muir
Annabel Sousa
Laurel Willmott
Arlene Zaldivar
Baruchel S: National Order of Merit, France,
2006.
Blanchette V: Dr. Cecil Harris Award, Canadian
Haemophilia Society. 2006.
Bouffet E: Claus Wirsig Humanitarian Award,
2007.
Bouffet E: Ontario Institute of Cancer Research,
2007.
Bouffet E: The Richard Rowe Award for Clinical
Excellence in Paediatric Medical Care, 2007.
Dror Y: Canadian Institutes of Health Research
Clinical Investigator Award, 2006.
Huang A: LIMA International Award for Excellence
in Pediatric Brain Tumor Research, Children’s
Brain Tumor Foundation, 2006.
Kahr W: Phase II Clinician Scientist Award, The
Heart and Stroke Foundation of Ontario, 2006.
Malkin D: Physician Researcher Award for
Scientific Accomplishment, Department of
Paediatrics, The Hospital for Sick Children,
University of Toronto, 2006.
Odame I: Holland Memorial Award for Professional
Excellence, 2007.
Tabori U: 18th Annual Paediatric Resident/Fellow
Research Competition, First prize, 2006.
Tabori U: Young Investigators Award, The Canadian
Neuro-Oncology Society, 2006.
Tabori U: 3rd Prize, Department of Paediatrics
Resident and Fellows Research Day Competition,
The Hospital for Sick Children, 2006.
Tabori U: Merit Award, American Society of
Clinical Oncology Annual Meeting, 2006.
Weitzman S: Richard Rowe Award for Clinical
Excellence in the Department of Paediatrics, 2006.
PUBLICATIONS
Abdelhaleem M, Beimnet K, Kirby-Allen M, Naqvi
A, Hitzler J, Shago M: High incidence of CALMAF10 fusion and the identification of a novel
fusion transcript in acute megakaryoblastic
leukemia in children without Down’s syndrome.
Leukemia 2007: 21: pp 352-353.
Abdelhaleem M, Shago M, Abla O: TEL-AML1
fusion in acute lymphoblastic leukemia with L3
morphology. Pediatric Blood Cancer 2007: 49:
p 217.
Abdelhaleem M, Yi Q, Beimnet K, Grant RM:
A novel t(4;11)(q21;q23) MLL-AF4 fusion
transcript in infant leukemia. American Journal
of Hematology 2007: 82: p 247.
46
DEPARTMENT OF PAEDIATRICS
Abdelhaleem M, Yi Q, Beimnet K, Hitzler J: A novel
TEL-AML1 fusion transcript involving the proapoptotic gene BCL-G in pediatric precursor B
acute lymphoblastic leukemia. Leukemia
2006:20: p 1294.
Bartels U, Hawkins C, Ma J, Ray A, Dirks P,
Rutka J, Stephens D, Bouffet E: Vascularity and
angiogenesis as predictors of growth in optic
pathway/hypothalamic gliomas. Journal of NeuroSurgery 2006: 104: pp 314-320.
Abla O, Sandlund J, Sung L, Brock P, Corbett R,
Kirov I, Griffin T, Blaser S, Weitzman S: A case
series of pediatric primary central nervous system
lymphoma- favourable outcome without cranial
irradiation. Pediatric Blood Cancer 2006: 47:
pp 880-885.
Bartels U, Shroff M, Sung L, Dag-Ellams U,
Laperierre N, Rutka J, Bouffet E: The role of spinal
MRI in the follow-up of children treated for medulloblastoma. Cancer 2006: 15: pp 1340-1347.
Abla O, Weitzman S: Primary central nervous
system lymphoma in children. Neurosurgery Focus
2006: 21: p e8.
Abla O, Ye CC: Acute lymphoblastic leukemia
with massive myelofibrosis. Journal of Pediatric
Hematology Oncology 2006: 28: pp 633-634.
Al-Faris N, Al-Harbi T, Boia G, Pappo A, Doyle J,
Gassas A: Does consolidation with autologous
bone marrow transplantation improve the
outcome of children with metastatic or relapsed
Ewing’s sarcoma? Pediatric Blood and Cancer
2007: 49: pp 190-195.
Anderson D, Ali K, Blanchette V, Brouwers M,
Couban S, Radmoor P, Huebsch L, Hume H,
McLeod A, Meyer R, Molzan C, Nahirniak S, Nantel
S, Pineo G, Rock G: Guidelines on the use of
intravenous immune globulin for hematologic
conditions. Transfusion Medicine 2007: 2:
pp S9-s56.
Arnold DM, Julian JA, Walker IR for the
Association of Hemophilia Clinic Directors of
Canada (AHCDC): Mortality rates and causes of
death among all HIV-positive individuals with
hemophilia in Canada over twenty-one years of
follow-up. Blood 2006: 108: pp 460-464.
Barlow JW, Wiley JC, Mous M, Narendran A,
Gee MFW, Goldberg M, Sexsmith E, Malkin D:
Differentiation of rhabdomyosarcoma cell lines
using retinoic acid. Pediatric Blood and Cancer
2006; 47: pp 773-784.
Barnes C, Blanchette V, Lillicrap D, Mann K,
Stain AM, Leggo J, Hilliard P, Carcao M: Different
clinical phenotype in triplets with haemophilia A.
Haemophilia 2007: 13: pp 202-205.
Barnes C, Lillicrap D, Pazmino-Canizares J,
Blanchette VS, Stain AM, Clark D, Hensmen C,
Carcao M: Pharmacokinetics of recombinant
factor VIII (Kogenate-FS) in children and causes
of inter-patient pharmacokinetic variability.
Haemophilia 2006: 12: pp 40-49.
Barr RD, Barrera M, Greenberg ML: Walking two
worlds- Adolescent and Young Adult Oncology.
Proceedings of the POGO Conference 2003.
Cancer 2006: 107: p 1643.
ANNUAL REPORT 2006-07
Baruchel S: Low-Dose Metronomic Chemotherapy:
Myth or Truth? Onkologie 2006: 29: pp 305-307.
Baruchel S, Diezi M, Hargrave D, Stempak D,
Gammon J, Moghrabi A, Coppes MJ, Fernandez
CV, Bouffet E: Safety and pharmacokinetics of
temozolomide using a dose-escalation,
metronomic schedule in recurrent paediatric brain
tumours. European Journal of Cancer 2006: 42:
pp 2335-2342.
Belletrutti M, Ali K, Barnard D, Blanchette V,
Chan A, David, M, Luke B, Price V, Ritchie B,
Wu J, Canadian Pediatric Chronic ITP Working
Group: Canadian Pediatric Thrombosis and
Hemostasis Network (CPTHN): Chronic immune
thrombocytopenic purpura in children: a survey
of the Canadian experience. Journal of Pediatric
Hematology/Oncology 2007: 29: pp 95-100.
Berntorp E, Abshire T, Carcao M for the von
Willebrand Disease Prophylaxis Network: Letter
to the Editor: The von Willebrand disease
prophylaxis network: exploring a treatment
concept. Journal of Thrombosis and Haemostasis
2006: 4: pp 2511-2512.
Berntorp E, Shapiro A, Astermark J, Blanchette
VS, Collins PW, Dimichele D, Escuriola C,
Hay CRM, Hoots WK, Leissinger CA, Negrier C,
Oldenburg J, Peerlinck K, Reding MT, Hart C:
Inhibitor treatment in haemophilias A and B:
Summary statement for the 2006 International
Consensus Conference. Haemophilia 2006:
12: pp 1-7.
Bertolini F, Baruchel S, Stempak D, Crump M,
Taylor D, Zhang L, Man S, Kerbel R, Shaked Y,
Foden C, Lee C, Maya R: High dose celecoxib
and metronomic �low dose’ cyclophosphamide
is an effective and safe therapy in patients with
relapsed and refractory aggressive histology
NHL. Clinical Cancer Research 2006: 12:
pp 5190-5198.
Bradley CS, Bullinger M, McCusker PJ, Wakefield
CD, Blanchette VS, Young NL: Comparing two
measures of quality of life for children with
haemophilia: the CHO-KLAT and the Haemo-QoL.
Haemophilia 2006: 12: pp 643-653.
Carcao MD, Aledort LM: Prophylaxis in the
haemophilia population – optimizing therapy.
Haemophilia 2007: 13: pp 227-232.
Drs. Isaac Odame and Melanie Kirby and the Haemoglobinopathy Team
HONOURS AND AWARDS
48
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
Carret AS, Tabori U, Crooks B, Hukin J, Odame I,
Johnston DL, Keene DL, Freeman C, Bouffet E:
Outcome of secondary high-grade glioma in
children previously treated for a malignant
condition: A study of the Canadian pediatric brain
tumour consortium. International Journal of
Radiation Oncology, Biology, Physics 2006: 81:
pp 33-38.
Evans AJ, Losada OR, Russell RC, Burry TN, Fish
JE, Maynard MA, Gervais ML, Sufan RI, Roberts
AM, Vandewalle C, Berx G, Marsden PA, Irwin MS,
Teh BT, Jewett MAS, Ohh M: VHL promotes ECadherin transactivation via HIF-dependent
regulation of SIP1 and snail: implications for renal
cell carcinoma. Molecular and Cellular Biology
2007: 27: pp 157-169.
Hyder DJ, Sung L, Pollack IF, Gilles FH, Yates AJ,
Davis RL, Boyett JM, Finlay JL: Anaplastic mixed
gliomas and anaplastic oligodendroglioma in
children: results from the CCG 945 experience.
Journal of Neurooncology 2007: 83: pp 1-8.
Cheretakis C, Leung R, Sun CX, Dror Y, Glogauer
M: Timing of neutrophil tissue repopulation
predicts restoration of innate immune protection
in a murine bone marrow transplant model. Blood
2006: 108: pp 2821-2826.
Gassas A, Evans AW, Armstrong C, Doyle JJ: Open
wound chronic skin graft-vs.-host disease. Are
these wounds ischemic? Pediatric Transplantation
2007: 11: pp 101-104.
Keene D, Johnston D, Strother D, Rrossard J,
Carret AS, Crooks B, Eisenstat D, Fryer F,
Mpofu C, Moghrabi A, Odame I, Zelcer S, Silva S,
Wilson B, Samson Y, Hand J, Bouffet E:
Epidemiological survey of central nervous system
germ cell tumours in Canadian Children. Journal
of NeuroOncology 2006: 82: pp 289-295.
Cheretakis C, Locker D, Dror Y, Glogauer M: Oral
health-related quality of life of children with
neutropenia. Special Care in Dentistry 2007: 27:
pp 6-11.
Chow LML, Nathan PC, Hodgson DC, Jenkin D,
Weitzman S, Grant RM, Manson D, Bross A, Doyle
JJ, Danjoux C, Greenberg M: Survival and late
effects in children with Hodgkin’s lymphoma
treated with MOPP/ABV and low-dose extendedfield irradiation. Journal of Clinical Oncology
2006: 24: pp 5735-5741.
Das PK, Carcao M, Hitzler J: Use of recombinant
factor VIIa in patients with acute leukemia and
abnormal coagulation screen prior to lumbar
puncture. Pediatric Blood and Cancer 2006: 47:
pp 206-209.
Das PK, Wherrett D, Dror Y: Remission of severe
aplastic anemia induced by treatment of Grave’s
disease in a pediatric patient. Pediatric Blood and
Cancer 2006: 49: pp 210-212.
Dr. Victor Blanchette and the Comprehensive Care Haemophilia Team
Dekker A, Bulley S, Beyene J, Dupuis LL, Doyle JJ,
Sung L: Meta-analysis of randomized controlled
trials of prophylactic granulocyte colonystimulating factor and granulocyte-macrophage
colony-stimulating factor after autologus and
allongeneic stem cell transplantation. Journal of
Clinical Oncology 2006: 24: pp 5207-5215.
Diaz RJ, Bouffet E: New frontiers in paediatric
medulloblastoma. University of Toronto Medical
Journal 2006: 84: pp 26-31.
DiPaola J, Aledort L, Britton H, Carcao M,
Grabowski E, Hutter J, Journeycake J, Kempton C,
Leissinger C: Application of current knowledge to
the management of bleeding events during
immune tolerance induction. Haemophilia 2006:
12: pp 591-597.
Dutta S, Price VE, Blanchette V, Langer JC: A
laparoscopic approach to partial splenectomy for
children with hereditary spherocytosis. Surgical
Endoscopy 2006: 20: pp 1719-1724.
Gassas A, Sung L, Saunders EF, Doyle JJ:
Comparative outcome of hematopoietic stem cell
transplantation for pediatric acute lymphoblastic
leukemia following cyclophosphamide and total
body irradiation or VP16 and total body irradiation
conditioning regimens. Bone Marrow
Transplantation 2006: 38: pp 739-743.
Gharib MI, Bulley S, Doyle JJ, Wynn RF: Venous
occlusive disease in children. Thrombosis
Research 2006: 118: pp 27-38.
Gong GWK, Barrera M, Beyene J, Bhat S, Carcao
M, Lord S, Narayanan UG, Sung L, Young NL,
Feldman BM: The Gap Study (GapS) Interview –
developing a process to determine the meaning
and determinants of quality of life in children
with arthritis and rheumatic disease. Clinical and
Experimental Rheumatology 2007: 25:
pp 149-155.
Greenberg ML, Urbach SL: Preserving the fertility
in children with cancer. Medical Journal of
Australia 2006: 185: pp 532-533.
Gupta A, Kumar A, Walters S, Chait P, Irwin MS,
Gerstle JT: Analysis of needle versus open biopsy
for the diagnosis of advanced stage pediatric
neuroblastoma. Pediatric Blood and Cancer 2006:
47: pp 875-879.
Gupta AA, Pappo AS: New Drugs for the treatment
of metastatic or refractory soft tissue sarcomas in
children. Future Oncology 2006: 2: pp 675-685.
Hendershot E, Pappo A, Malkin D, Sung L: Tumor
necrosis in pediatric osteosarcoma: Impact of
modern therapies. Journal of Pediatric Oncology
Nursing 2006 23: pp 176-181.
Hernandez de Mezerville M, Tellier R, Richardson
S, Hebert D, Doyle J, Allen U: Adenoviral
infections in pediatric transplant recipients.
A hospital-based study. Pediatric Infectious
Disease Journal 2006: 25: pp 815-818.
Hukin J, Steinbok P, Lafay-Cousin L, Hendson G,
Strother D, Mercier C, Samson Y, Howes W,
Bouffet E: Intracystic bleomycin therapy for
craniopharyngioma in children: the Canadian
experience. Cancer 2007: 109: pp 2124-2131.
Irwin MS: _Np73-misunderstood protein?
Cancer Biology and Therapy 2006: 5: 804-807.
Khanani F, Al Ahmari A, Tellier R, Allen U, Doyle J,
Richardson S, Gassas A: HHV7 infection in
pediatric stem cell transplantation. Pediatric
Blood and Cancer 2007: 48: pp 567-570.
Klein-Geltink J, Pogany L, Mery LS, Barr RD,
Greenberg ML: Impact of age and diagnosis on
waiting times between important health care
events among children 0 to 19 years cared for
in paediatric units: The Canadian Childhood
Cancer Surveillance and Control Program.
Journal of Pediatric Hematology/Oncology 2006:
28: pp 433-439.
Komvilaisak P, Blanchette V: Pharmacokinetic
studies of coagulation factors: relevance of
plasma and extracellular volume and body weight.
Haemophilia 2006: 12: pp 33-39.
Komvilaisak P, Connolly B, Naqvi A, Blanchette V:
Overview of the use of implantable venus access
devices in the management of children with
inherited bleeding disorders. Haemophilia 2006:
12: pp 87-93.
Lafay-Cousin, Millar BA, Mabbott DJ, Spiegler B,
Drake J, Bartels U, Huang A, Bouffet E: Limited
field radiation for bifocal germinoma. International
Journal of Radiation Oncology, Biology, Physics
2006: 65: pp 486-492.
Larouche V, Capra M, Huang A, Bartels U, Bouffet
E: Supratentorial primitive neuroectodermal
tumors in young children. Journal Clinical
Oncology 2006: 24: pp 5609-5610.
Lau L, Hansford L, Cheng LS, Hang M, Baruchel S,
Kaplan Dr, Irwin MS: Cyclooxygenase inhibitors
modulate the p53/HDM2 pathway and enhance
chemotherapy-induced apoptosis in neuroblastoma. Oncogene 2007: 26: pp 1920-1931.
Levine DS, Navarro OM, Chaudry G, Doyle JJ,
Blaser SI: Imagining the complications of bone
marrow transplantation in children. RadioGraphics
2007: 27: pp 307-324.
Mabbott DJ, Noseworthy M, Bouffet E, Laughlin S,
Rockel C: White matter growth as a mechanism
of cognitive development in children. Neurolmage
2006: 15: pp 936-946.
Mannucci PM, Abshire T, Dimichele D, Santagostino
E, Blanchette V: Inhibitor development, immune
tolerance and prophylaxis in haemophilia A:
The need for an evidence-based approach.
Haemophilia 2006: 12: pp 429-434.
Mansky P, Arai A, Stratton P, Bernstein D, Long L,
Reynolds J, Chen D, Steinberg SM, Lavende N,
Hoffman K, Nathan PC, Parks R, Augustine E,
Chaudhry U, Derdak J, Wiener L, Gerber L, Mackall
C: Treatment late effects in long-term survivors of
pediatric sarcoma. Pediatric Blood & Cancer
2007: 48: pp 192-199.
Nathan PC, Jovcevska V, Ness KK, D’Agostino NM,
Staneland P, Urbach SL, Barron M, Barrera M,
Greenberg ML: The prevalence of overweight and
obesity in pediatric survivors of cancer. Journal of
Pediatrics 2006: 149: pp 518-525.
Nathan PC, Whitcomb T, Wolters PL, Steinberg
SM, Balis FM, Brouwers P, Hunsberger S, Bleyer
WA, Feusner J, Sather H, Miser J, Odom LF,
Poplack D, Reaman G: Very high-dose methotrexate
(33.6g/m2)) as CNS preventive therapy for
childhood acute lymphoblastic leukemia: Results of
National Cancer Institute/Children’s Cancer Group
trials CCG-191P, CCG-134P and CCG-144P.
Leukemia & Lymphoma 2006: 47: pp 2488-2504.
Ota S, McLimont M, Carcao MD, Blanchette VS,
Graham N, Paradis E, Feldman BM: Definitions
for haemophilia prophylaxis and its outcomes: The
Canadian consensus study. Haemophilia 2007:
13: pp 12-20.
Parshuram C, Dupuis L, To T, Weitzman S,
Koren G, Laupacis A: Occurrence and impact
of unanticipated variation in intravenous
methotrexate dosing. The Annals of
Pharmacotherapy 2006: 40: pp 805-811.
Pope E, Krafchik BR, Macarthur C, Stempak D,
Stephens D, Weinstein M, Ho N, Baruchel S:
Oral versus high-dose pulse corticosteriods in
problematic infantile hemangiomas: A randomized
controlled trial. Pediatrics 2007: 119:
pp 1239-1247.
Qaddoumi I, Mansour A, Musharbash A, Drake J,
Swaidan M, Tihan T, Bouffet E: Impact of
telemedicine on pediatric neurooncology in a
developing country: The Jordanian-Canadian
experience. Pediatric Blood Cancer 2007: 48:
pp 39-43.
Rachmiel M, Charron M, Gupta A, Hamilton J,
Wherrett D, Forte V, Daneman D: Evidence-based
review of treatment and follow-up of pediatric
patients with differentiated thyroid carcinoma.
Journal of Pediatric Endocrinology and
Metabolism 2006: 19: pp 1377-1393.
50
DEPARTMENT OF PAEDIATRICS
Ramphal R, Pappo AS, Zielenska M, Pereira C,
Grant RM, Ngan BY: Pediatric renal cell
carcinoma: Clinical, pathological and molecular
abnormalities associated with the members of the
Mit transcription factor family. American Journal of
Clinical Pathology 2006: 126: pp 332-334.
Rujkijyanont P, Beyene J, Wei K, Kahn F, Dror Y:
Leukaemia-related gene expression in bone
marrow cells from patients with the pre-leukaemic
disorder Shwachman-Diamond syndrome. British
Journal of Haematology 2007: 137: pp 537-544.
Sahgal A, Millar B-A, Michaels H, Jaywant S, Chan
HSL, Heon E, Gallie BL, Laperriere M: Focal
stereotactic external beam radiotherapy as visionsparing modality for treatment of peripapillary and
perimacular retinoblastoma: Preliminary results.
Clinical Oncology 2006 18: pp 628-634.
Schechter T, Finkelstein Y, Doyle J, Verjee Z,
Moretti M, Koren G, Dupuis LL: Pharmacokinetic
disposition and clinical outcomes in infants and
children receiving intravenous busulfan for
allogeneic hematopoietic stem cell
transplantation. Biology of Blood and Marrow
Transplantation 2007: 13: pp 307-314.
Schmugge M, Bang KWA, Blanchette VS, Albisetti
M, Connolly BL, Freedman J, Rand ML: Von
Willebrand factor binding to platelets and platelet
activation in newborn infants with central venous
lines. Acta Haematology 2006: 117: pp 145-148.
Seely D, Stempak D, Baruchel S: A strategy for
controlling potential interaction between natural
health products and chemotherapy: A review in
pediatric oncology. Journal of Pediatric
Hematology Oncology 2007: 29: pp 32-47.
Spiegler B, Kennedy K, Maze R, Greenberg ML,
Weitzman S, Hitzler JK, Nathan PC: Comparison of
long-term neurocognitive outcomes in young
children with ALL treated with cranial radiation or
high-dose or very high-dose intravenous
methotrexate. Journal of Clinical Oncology 2006:
24: pp 3858-3864.
Steele JM, Sung L, Klaassen R, Fernandez CV,
Yanofsky R, Wu J, Odame I, Silva M., Champagne J,
Ali, K, Brossard J, Samson Y, Abish S, Le D, Jardine
L, Hand JP, Lipton JH, Charpentier K, Stephens D,
Freedman M, Dror Y: Disease progression in
recently diagnosed patients with inherited marrow
failure syndromes: A Canadian Inherited Marrow
Failure Registry (CIMFR) Report. Pediatric Blood
and Cancer 2006: 47: pp 918-925.
Stempak D, Gammon J, Halton J, Moghrabi A,
Koren G, Baruchel S: A pilot pharmacokinetic
and antiangiogenic biomarker study of celecoxib
and low-dose metronomic vinblastine or
cyclophosphamide in pediatric recurrent solid
tumors. Journal of Pediatrics Hematology
Oncology 2006: 28: pp 720-728.
ANNUAL REPORT 2006-07
Stempak D, Seely D, Baruchel S: Metronomic
dosing of chemotherapy: applications in pediatric
oncology. Cancer Investigation 2006: 24:
pp 432-443.
Stevens B, McKeever P, Law MP, Booth M,
Greenberg ML, Daub S, Gafni A, Gammon J,
Yamada J, Epstein I: Children receiving
chemotherapy at home: Perceptions of children
and parents. Journal of Pediatric Oncology
Nursing 2006: 23: pp 276-285.
Strahm B, Malkin D: Hereditary cancer
predisposition in children: molecular basis and
clinical implications. International Journal of
Cancer 2006: 119: pp 2001-2006.
Sun Y, Boyd K, Xu W, Ma J, Jackson CW, Fu A,
Shillingford JM, Robinson GW, Henninghausen L,
Hitzler JK, Ma Z, Morris SW: Acute myeloid
leukemia-associated Mkl1 (Mrtf-a) is a key
regulator of mammary gland function. Molecular
Cell Biology 2006: 26: pp 5809-5826.
Sung L, Dror Y: Clinical applications of
granulocyte-colony stimulating factor. Frontiers
in Bioscience 2007: 12: pp 1988-2002.
Sung L, Johnston D: Approach to febrile
neutropenia in the general paediatric setting.
Paediatric and Child Health 2007: 11: pp 19-21.
Sung L, Tomlinson GA, Greenberg ML, Koren G,
Judd P, Ota S, Feldman BM: Serial controlled
N-of-1 trials of topical vitamin E as prophylaxis
for chemotherapy-induced oral mucositis in
paediatric patients. European Journal of Cancer
2007: 43: pp 1269-1275.
Sung L, Tomlinson GA, Greenberg M, Koren G,
Judd P, Ota S, Feldman BM: Validation of the oral
mucositis assessment scale in paediatric cancer.
Pediatric Blood & Cancer 2007: 49: pp 149-153.
Tabori U, Dome J: Telomere biology of pediatric
cancer. Cancer Investigation 2007: 25:
pp 197-208.
Tabori U, Jones H, Malkin D: Low risk of
complications in severely neutropenic children
with cancer at an overnight recreational summer
camp. Pediatric Blood and Cancer 2007: 48:
pp 148-151.
Tabori U, Nanda S, Lees J, Malkin D: Younger age
of cancer initiation is associated with shorter
telomere length in Li- Fraumeni syndrome. Cancer
Research 2007: 67: pp 1415-1418.
Tabori U, Revach G, Nathan P, Strahm B, Rachlis
A, Shago A, Grant R, Doyle J, Malkin D: Toxicity
and outcome of children with treatment related
acute myeloid leukemia. Pediatric Blood and
Cancer January 24, 2007 [Epub ahead of print].
Dr. Oussama Abla
Mabbott DJ, Noseworthy D, Bouffet E, Rockel C,
Laughlin S: White matter and IQ after radiation
for paediatric medulloblastoma: a diffusion tensor
imaging study. Neuro-Oncology 2006: 8:
pp 244-252.
Tomlinson D, Capra M, Gammon J, Volpe J,
Barrera M, Hinds PS, Bouffet E, Greenberg ML,
Baruchel S, Llewellyn-Thomas HA, Sung L:
Parental decision making in pediatric cancer endof-life care: using focus group methodology as a
pre-phase to seek participant design input.
European Journal of Oncology Nursing 2006: 10:
pp 198-206.
Valentino LA, Santagostino E, Blanchette V, van
den Berg M: Managing the pediatric patient and
the adolescent/adult transition. Seminars in
Thrombosis and Hemostasis 2006: 32: pp 28-31.
van den Berg HM, Dunn A, Fischer K, Blanchette
VS: Prevention and treatment of musculoskeletal
disease in the haemophilia population: Role of
prophylaxis and synovectomy. Haemophilia 2006:
12: pp 159-168.
Watson IR, Blanch A, Lin DCC, Ohh M, Irwin MS:
MDM-2 mediated Nedd 8 modification of TA p73
regulates its transactivation function. Journal
of Biological Chemistry 2006: 281:
pp 34096-34103.
Watson IR, Irwin MS: Regulation of p53 family
proteins by ubiquitin and ubiquitin-like molecules.
Neoplasia 2006: 8: pp 655-666.
West AN, Neale GA, Pounds S, Figueredo BC,
Galindo CR, Pianovski MAD, Filho AGO, Malkin D,
Lalli E, Ribeiro R, Zambetti GP: Gene expression
profiling of childhood adrenocortical tumors.
Cancer Research 2007: 67: pp 600-608.
Young NL, Bradley CS, Wakefield CD, Barnard D,
Blanchette VS, McCusker PJ: How well does the
Canadian Haemophilia Outcomes-Kids’ Life
Assessment Tool (CHO-KLAT) measure the quality
of life of boys with haemophilia? Pediatric Blood
and Cancer 2006: 47: pp 305-311.
Young NL, Wakefield CD, Bradley CS, Blanchette
VS, Barnard D, McCusker P: Returning the focus
to the quality of life of boys with haemophilia.
Pediatric Blood and Cancer 2007: March 2, 2007
[Epub ahead of print].
Zhang L, Yeger H, Das B, Irwin MS, Baruchel S:
Tissue microenvironment modulates CXCR4
expression and tumor metastasis in
neuroblastoma. Neoplasia 2007: 9: pp 36-46.
Zukotynski K, Jarrin J, Babyn P, Carcao M,
Pazmino-Canizares J, Stain AM, Doria AS:
Sonography for assessment of haemophilic
arthropathy in children: A systematic protocol.
Haemophilia 2007: 13: pp 293-304.
BOOKS AND BOOK CHAPTERS
Bouffet E, Hodgson DC, Koh ES: Pediatric
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Jersey, 2006.
Irwin MS, Malkin D: Li Fraumeni Syndrome and
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London, 2006.
Acute Megakaryocytic Leukemia in Down
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Canada ($137,484 2005-2009)
Biochemical and genetic analyses of JPO2, a
novel of c-Myc oncogene interacting protein.
Huang A. National Cancer Institute of Canada
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Biochemical and genetic analyses of JPO2, a
novel c-Myc oncogene interacting protein
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of Canada ($29,479 2006-2007)
Jouvet A, Fauchon F, Bouffet E, Saint-Pierre G,
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D’Agostino N, Guger S, Staneland P, Lough M,
Laperriere N, Urbach S, Nathan P. Princess
Margaret Hospital Psychosocial Oncology and
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Khetan V, Chan HSL, Wang L, Gallie BL:
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Sobin LH, eds). John Wiley & Sons Inc., New
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2002-2007; additional $216,000 operating funds
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FUNDING
Cancer and chemosensitivity. Irwin MS.
Premier’s Research Excellence Award ($150,000
2004-2009)
Careful transitions: developing and integrated
service delivery model for paediatric palliative
care. Antle B, Newman C, Beaune L, Rugg M,
Wheat A, Bouffet E, Laxer R, Frager G, Wagner F.
SickKids Foundation ($129,900 2006-2008)
A cross-sectional study of overweight in paediatric
survivors of acute lymphoblastic leukemia. Nathan
P, Barrera M, Barron M, Urbach S, D’Agostino N,
Staneland P, Charron M, Greenberg M. Faculty of
Medicine Dean’s Fund ($10,000 2007)
Celecoxib enhances chemosensitivity of
neuroblastoma: Molecular pathways and
therapeutic applications. Irwin MS. James Birrell
Neuroblastoma Research Fund ($29,700
2004-2007)
A group wide phase II study of ET-743 in recurrent
paediatric sarcoma. Baruchel S. Children’s
Oncology Group ($75,000 2007-2010)
Characterization of a novel family of Myc protein
interactors and their role in medulloblastoma
transformation. Huang A. Eli-Lilly/Cancer Care
Ontario/Canadian Institutes of Health Research
($675,000 2004-2007)
A phase I study of Sorafenib in recurrent solid
tumors. Reference laboratory. Wideman B,
Baruchel S. Children’s Oncology Group ($32,000
2007-2008)
A phase II study of vinblastine in chemotherapy
naive children with progessive low grade gliomas.
Bouffet E, Tabori U, Hawkins C, Keene D.
Ontario Institute of Cancer Research ($430,197
2007-2010)
A randomized study of IVIG vs IVIG with high
dose methylprednisolone in rapidly augmenting
platelet counts in childhood ITP. Carcao M,
Blanchette V. Bayer (Canada) Incorporated
($145,065 2004-2006)
Characterization of JPO2, a novel c-Myc cotransforming protein. Rodrigues T and Huang A.
Canadian Institute of Health Research Doctoral
Research Awards ($63, 000 2007-2010)
Children with posterior fossa brain tumours:
quality of life and predictors of outcome. Kulkarni
A, Bouffet E, Pakulis J, Ellerton C, Shams I.
b.r.a.i.n.child, The Hospital for Sick Children
($42,685 2006-2008)
Clinical Trial Consortium. Pappo A, Bouffet E,
Baruchel S. Ontario Cancer Research Network
($1,000,000 2005-2008)
Comparative effectiveness of conventional and
informatics-assisted clinical management and
clinical trial participation. Gallie BL, Chan HSL,
Eysenbach G, Kushniruk A, Heon E. Ontario
Institute for Cancer Research ($446,066 20032006 with 2-year no cost extension 2007-2008)
Cross-cultural validation of the CHO-KLAT
(Canadian Haemophilia Outcomes – Kids’ Life
Assessment Tool). Blanchette V, Young N,
McCusker P. Bayer HealthCare Canada
($260,000 2006-2008)
Defining the clinical phenotype of inherited
marrow failure syndromes and the risk factors of
severe haematological complications and cancer
by the Canadian Inherited Marrow Failure Registry
(CIMFR). Dror Y. Council of Canadian Paediatric
Haematology/Oncology Directors Research
Network ($83,000 2005-2007)
Determining the potential for drug interactions
between Natural Health Products (NHPs) and
chemotherapy in a paediatric onocology
population. Baruchel S, Mills E, Guyatt G, Koren
G, Seely D, Stempak D, Zelunka E. The Hospital
for Sick Children ($130,000 2005-2006)
Development and validation of comparative
genomic hybridization arrays for clinical use in
cancer. Horsman D, Law W, Huang A, Squire J,
Rutka J. Genome Canada ($4,600,000
2004-2007)
Development of a feasible tool to measure oral
mucositis in children with cancer. Sung L, Judd P,
Tomlinson D, Doyle JJ, Hendershot EI, Maloney
AM, Feldman BM. Pediatric Oncology Group of
Ontario ($13,334 2007-2008)
Educational Grant to review 1) usage patterns of
rFVIIa; 2) impact of acquired coagulopathies in
leukaemia patients; and 3) inhibitor development
in mild haemophilia all at The Hospital for Sick
Children. Carcao MD. Novo Nordisk Inc. ($34,750
2006-2007)
Establishing surrogate markers of angiogenesis
in paediatric oncology phase I and II clinical trials:
A Children’s Oncology Group Study. Baruchel S,
Stempak D, Bertolini F, Entz-Werle N. Alex’s
Lemonade Stand Foundation ($198,417
2007-2009)
Functional analysis of p73: Roles in
chemosensitivity and apoptosis. Irwin MS.
National Cancer Institute of Canada ($479,941
2003-2007)
Functional analysis of the p53 family members
p73 and p63 roles in apoptosis, development
and cancer. Irwin MS. Canada Research Chair;
Tier II ($500,000 2003-2008)
Genetic epidemiology of osteosarcoma. Spector L,
Malkin D, Ross, J, Sklar C, Nagarajan R. National
Institutes of Health ($1,000,000 2006-2011)
Genetic variation and risk of infection in children
with primary acute myeloid leukaemia. Sung, L.
Early Research Award – Ministry of Research and
Innovation ($100,000 2007-2011)
Infrastructure Grant Paediatric Consortium.
Blanchette VS, Devine S (Co-PI), Site PI’s:
Weitzman S, Portwine C, Halton J, Jardine L,
Silva M. Ontario Cancer Research Network
(OCRN) ($990,404 2006-2011)
Genetics, genomic research and consent:
attitudes of paediatric cancer survivors.
Patenaude A, Malkin D. National Institutes of
Health ($100,000 2006-2008)
International Prophylaxis Study Group.
Blanchette VS. Bayer, Baxter BioScience, Aventis
and Wyeth/GI ($750,000 2002-2006)
Genomic analyses of paediatric supratentorial
primitive neuroectodermal tumours. Huang A.
Children’s Brain Tumour Foundation ($150,000
2005-2007)
In vivo anti-tumour and anti-metastatic activity
of administration of CXCR4 antagonist and antiCTLA4 in neuroblastoma. Baruchel S. Pfizer
Canada Inc. ($45,000 2007-2008)
Genomic analyses of paediatric supratentorial
primitive neuroectodermal tumours. Huang A,
Li M, Rutka J. American Brain Tumour Association
Basic Science Research Award ($70,000
2006-2008)
In vivio anti-tumour and anti-metastatic activity of
administration of Sutent and low-dose
chemotherapy in preclinical neuroblastoma mouse
model. Baruchel S., Zhang L. Pfizer Canada Inc.
($50,000 2007-2008)
Genomic analyses of sPNET. Huang A.
b.r.a.i.n.child, The Hospital for Sick Children
($84,300 2005-2007)
Measurement properties of ultrasound for
assessment of haemophilic arthropathy. MRI
correlation. Doria, A, Srivastava A, Gibikote S,
Keshava SN, Poonnoose P, Blanchette V, Babyn P,
Hilliard, P. Bayer HealthCare Canada ($170,000
2006-2007)
Group Chair Grant, Children’s Oncology Group.
Institutional Principal Investigator: Malkin D.
National Cancer Institute (US$900,000
2003-2008)
Hope: The complex journey of parents of children
with cancer. Antle B, Barrera M, Beaune L, Capra
M, D’Agostino N, Maloney AM, Nicholas D, Volpe
J. Canadian Institutes of Health Research
($291,067 2005-2008) and b.r.a.i.n.child, The
Hospital for Sick Children ($25,000 2005-2008)
Identification of genes involved in marrow failure
and malignant myeloid transformation by gene
expression analysis of bone marrows from
patients with inherited marrow failure syndromes.
Dror Y, Beyene J. Anemia Institute of Research
and Education ($60,000 2004-2006)
Identification of genetic pathways that regulate
survival and development of cancer and cancer
stem cells. Guidos C, Hitzler J. Genome Canada
($330,000 2005-2009)
Identification of interstitial germline deletions in
children with complex clinical syndromes that
include medulloblastoma. Taylor M, Bouffet E.
Pediatric Brain Tumour Foundation Institute
Award ($100,000 2006-2008)
Improving communication during the palliative
care of children with brain tumours – learning
from experience. Bouffet E, Chau T, Beal D, Van
Halderen C, Brownstone D, Eaton C.
b.r.a.i.n.child, The Hospital for Sick Children
($49,592 2005-2007)
Improving the clinical management of paediatric
severe haemophilia A patients via laboratory
assessments of haemostasis. Kahr WHA,
Blanchette V. The Bayer-Canadian Blood Services
Partnership Fund ($148,420 2005-2007)
Mechanism of pre-B cell leukemogenesis.
Subversion of developmental and survival
programs in leukenogenesis. Guidos C, Hitzler J.
Specialized Center of Research; Leukemia
Lymphoma Society ($750,000 2004-2009)
Moderate term musculoskeletal outcomes
with escalating dose prophylaxis: The Canadian
Haemophilia Prophylaxis Follow-Up Study
(CHPS-3). Feldman BM, Blanchette VS. Bayer
(Canada) Incorporated ($742,500 2006-2009)
Molecular and pharmacologic correlates of acute
myeloid leukemia in Down syndrome. Taub J,
Hitzler J. National Institutes of Health
($2,189,783 2007-2011)
Molecular basis of CNS leukemia. Subversion of
developmental and survival programs in
leukemogenesis. Danska J, Hitzler J. Specialized
Center of Research; Leukemia Lymphoma Society
($750,000 2004-2009)
Molecular characterization of novel genes involved
in sPNET pathogenesis. Lee K and Huang A.
The Hospital for Sick Children Research Training
Competition Award ($19,000 2006-2007)
Molecular determinants of tumour formation in
Li-Fraumeni Syndrome. Malkin D. National Cancer
Institute of Canada ($387,000 2004-2007)
Molecular determinants of tumour formation in
Li-Fraumeni Syndrome. Malkin D. National Cancer
Institute of Canada ($423,000 2007-2010)
Neuroimaging and cognitive function in children
with brain tumours. Mabbott D, Bouffet E,
Noseworthy M, Laughlin S, Hyder D. SickKids
Foundation ($122,395 2003-2006)
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
53
New surrogate markers of angiogenesis in
paediatric brain tumours. Baruchel S, Bartels U,
Hawkins C, Stempak D, Bouffet E, Abdelhaleem
M, Doyle J. b.r.a.i.n.child, The Hospital for Sick
Children ($97,446 2006-2008)
Orphan late effect in paediatric brain tumour
survivors. Lafay-Cousin L, Sockett E, Bouffet E.
b.r.a.i.n.child, The Hospital for Sick Children
($30,000 2005-2007)
Paediatric Phase I Consortium. Baruchel S, Pappo
A, Gammon J. National Cancer
Institute/Children’s Oncology Group ($250,000
2002-2007)
Pain in child health: an innovative,
transdisciplinary, cross-Canada research training
consortium. McGrath PJ, Barr R, Baruchel S,
Brown S, Camfield C, Chambers C, Connolly J,
Craig K, Dube L, Feldman B, Finley G, Frager G,
Gibbins S, Grunau R, Harman K, Hetherington C,
Howlett A, Johnston C, Kenny N, Koren G,
Langer J, Murray M, Oberlander T, Ohlsson A,
Otley A, Rathwell T, Salter M, Schellinck H,
Stevens B, Taddio A, Unruh A, Von Baeyer C,
Walker C. Canadian Institutes of Health Research
($1,800,000 2002-2008)
Palliative chemotherapy versus supportive care
alone for end-of-life. Sung L, Hinds P,
Llewwllyn-Thomas H, Volpe J, Capra M, Gammon
J, Baruchel S, Bouffet E, Barrera M, Tomlinson D,
Greenberg ML. National Cancer Institute of
Canada ($131,626 2005-2008)
Parents of children with cancer. Klaassen A, Sung
L, Dix D, Pritchard S, Yanofsky R. National Cancer
Institute of Canada ($225,000 2004-2006)
Phase II study of high dose chemotherapy with
cyclosporin for vision-threatening intraocular
retinoblastoma. Chan HSL, Gallie BL, Heon E.
Ontario Institute for Cancer Research
($551,723 2003-2006 with 2-year no cost
extension 2007-2008)
Pilot study of combination therapy of
temozolomide and radiation therapy in brainstem
glioma. Barucel S, Bouffet E, Tariq N, Hargrave D.
b.r.a.i.n.child, The Hospital for Sick Children
($44,980 2001-2007)
54
DEPARTMENT OF PAEDIATRICS
Prospective cohort study of genetic variation and
risk of infection for Canadian children with newly
diagnosed acute myeloid leukemia. Sung L,
Beyene J, Allen U. Childhood Cancer Foundation
($17,000 2005-2006)
The prevalence of symptomatic von Willebrand
disease in the paediatric population. James PD,
Blanchette VS, Lillicrap D, Silva M, Rand ML,
Brandao L. Canadian Hemophilia Society
($139,800 2007-2009)
Prospective cohort study of genetic variation and
risk of infection in Canadian children with newly
diagnosed acute myeloid leukemia. Sung L,
Beyene J, Allen U. National Cancer Institute of
Canada ($444,424 2005-2008)
The role of SBDS in granulopoiesis. Dror Y.
SickKids Foundation ($64,480 2006-2008)
Role of p53 and VEGF signaling in paediatric
sarcomas. Malkin D. SickKids Foundation
($200,000 2002-2007)
Salary support for chairing a group-wide
prospective study of ototoxicity in children
receiving cisplatin chemotherapy. Sung L.
Children’s Oncology Group ($50,000 2005-2007)
Sibling and parent bereavement from childhood
cancer. Gerhardt C, Barrera M, Capra M. National
Cancer Institute of Canada, The Hospital for Sick
Children ($92,000 2005-2010)
Subversion of developmental and survival
programs in leukemogenesis. Project 1:
identification of leukemogenic genes that convert
a normal human hematopoietic cell into a
leukemic stem cell. Mak T, Dick J, Hitzler J.
Leukemia Lymphoma Society ($748,575
2004-2009)
Subversion of developmental and survival
programs in leukemogenesis. Project 2:
mechanism of pre B cell leukemogenesis.
Guidos C, Hitzler J. Leukemia Lymphoma Society
($750,000 2004-2009)
Subversion of developmental and survival
programs in leukemogenesis. Project 3: Molecular
basis of CNS leukemia. Danska J, Hitzler J.
Leukemia Lymphoma Society ($750,000
2004-2009)
Telomere maintenance in the biologic behaviour
of low-grade gliomas. Malkin D, Tabori U.
b.r.a.i.n.child, The Hospital for Sick Children
($60,000 2004-2007)
Thalassemia Clinical Research Network Registry.
Kirby M. National Institutes of Health ($45,696
2005-2010)
The MAST project: Magnesium for Sickle Cell Trial.
Goldman RD, Mounstephen W, Kirby-Allen M,
Friedman JN. Physicians’ Services Incorporated
Foundation ($163,846 2005-2007)
The Ontario Pediatric Oncology Clinical Trials
Research Network. Blanchette V, Malkin D,
Devine S, Baruchel S, Weitzman, S, Bouffet E.
Ontario Cancer Research Network ($1.2 million
2006-2009)
ANNUAL REPORT 2006-07
The role of SBDS in promoting cell survival.
Dror Y. Canadian Institutes of Health Research
($250,000 2006-2011)
The Role of SBDS in promoting cell survival.
Dror Y. SDS Project Incorporated ($30,000
2006-2007)
The role of SBDS in protection from apoptosis.
Watanabe K, Dror Y. The Hospital for Sick
Children Research Training Competition
($105,000 2004-2007)
The role of VPS33B in platelet alpha granule
formation. Kahr WHA. Dean’s Fund New Staff
Grant ($10,000 2006)
The role of VPS33B in platelet alpha granule
formation. Kahr WHA. The Heart and Stroke
Foundation of Ontario ($210,750 2006-2009)
The role of VPS33B in platelet alpha granule
formation. Kahr WHA. Canadian Institutes of
Health Research Canada ($441,912 2006-2010)
To improve infrastructure for paediatric cancer
clinical trials. Pappo A, Malkin D, Devine S, Hitzler
H, Silva M, Barr R, Halton J, Jardine L, Baruchel S,
Bouffet E. Ontario Cancer Research Network
($990,404 2005-2010)
Toronto Angiogenesis Research Centre. Kerbel R,
Baruchel S, Burns P, Dumont D, Hemkelman M.
Canada Foundation for Innovation 40%, OIT 40%,
and partner institutions 20% of total award
($11,630,155 2002-2006)
Treatment choices for children with typical acute
immune thrombocytopenic purpura: development
of a decision aid. Beck C, Parkin P, Birken C,
Blanchette V, Boydell K, Llewellyn-Thomas H.
Dean’s Fund New Staff Competition ($10,000
2006-2011)
Tumour volume as measurement of response to
chemotherapy in paediatric low grade gliomas.
Bartels U, Laughlin S, Mabbott D, Bouffet E.
b.r.a.i.n.child, The Hospital for Sick Children
($13,775 2006)
Validation of a new paediatric scoring system
from the International Hemophilia Prophylaxis
Study Group: Validity and reliability of the
combined hemophilia joint health score (HJHS).
Feldman B, Blanchette VS, Funk S, Bergstrom BM,
Zourikian, Hilliard P, van der Net JJ, Engelbert R,
Petrini P, van den Berg HM, Manco-Johnson M,
Rivard G. Bayer Healthcare LLC, Biological
Products Division ($195,000 2005-2007)
Dr. Uri Tabori and lab staff
Neuro-imaging of white matter and neuro-cognitive
outcome following cranial radiation for paediatric
brain tumours. Mabbot DJ, Bouffet E, Noseworthy
M, Suzanne M, Kulkarni A, Norman L, Michael S,
Montour-Proulx I, Daniel K, Strother D, Witol A,
Wilson B, Chafe S, McConnel D, Hukin J, Freyer C.
C17 Research Network ($95,000 2006-2008)
Division Head
Dr. Chaim Roifman
Full-Time
Dr. Adelle Atkinson
Dr. Eyal Grunebaum
Part-Time
Dr. Milton Gold
Dr. David Hummel
Dr. Sasson Lavi
Dr. Maria Triassi
Clinical Fellows
Dr. Maryam Al-Helale
Dr. Daifulah Alzahrani
Dr. Maitham Hussain
Dr. Fotini Kavadas
Dr. YewHon Lai
Dr. Elana Lavine
Dr. Raz Somech
Clinical Assistant
Dr. Sean Bulley
Immunology Nurse
Brenda Reid, CNS
Allergy Nurses
Kimberley Seaban, CNS
Elisabeth White, CNS
Senior Scientists
Amos Cohen, PhD
Sergio Grinstein
Research Associate
Nigel Sharfe, PhD
Research
Technologists
Lorand Cimpeon
Tom Grunberger
Yiping Gu
Vivien Lee
Weixian Min
Murugesapillai
Mylvaganam
JunYan Zhang
Medical Lab
Technologists
Andrea Bates
Harjit Dadi, PhD
Administrative Staff
Lucy Casamatta
Sandra Mendonca
Linda Quintal
Immunology/Allergy
DIVISIONAL OVERVIEW
The Division of Immunology/Allergy continues as a leader in
patient care, research and education in immunology. This year
marks the launch of the Canadian Jeffrey Modell Foundation (JMF)
Immunodeficiency Network and the Primary Immunodeficiency
(PID) Network in Israel. Under Dr. Roifman’s leadership, these
national programs are facilitating early recognition, diagnosis,
research and effective treatment of primary immune deficiencies.
Upcoming collaborations with the Canadian Jeffrey Modell
Network members truly illustrate our vision of providing timely and
optimal care to patients with PID worldwide.
Dr. Adelle Atkinson
The Primary Immunodeficiency program at The Hospital for Sick
Children is the largest centre of its kind in Canada. Medical
services are provided to over 2000 outpatients referred from
physicians and hospitals nationally. This number has steadily
increased by thirty percent over the last 10 years. To diminish
waiting time in the Immunology clinic we have recently
established the Complex Immunodeficiency Clinic. This addition
has improved evaluation of our complex patients by providing
extensive time and attention to their conditions.
The Hypogammaglobulinemia Program at SickKids is recognized
globally for its innovative approach and long-term follow-up of
over 150 patients. We transformed the therapy of these patients
from multiple hospital based admissions, to visiting the short
stay unit and subsequently receiving treatment in their
community. The proficiency of our team coupled with convenient
care at a medical centre close to home, provides our patients
with the personalized treatment they require. To further enhance
this program, we are now implementing home therapy as the
ideal model of treatment. Our recent symposium for a Canadian
consensus on home treatment has resulted in funding by
the Canadian Immunodeficiency Society (CI Society) and a
publication in the Journal of Clinical Immunology.
Innovative protocols created by members of the division have
elevated the profile of the Bone Marrow Transplantation (BMT)
program as one of the best in the world for survival of PID
patients. In 1990 we made history with implementing matched
unrelated donor transplants for PID. Today we demonstrate the
impact of our procedures with a recently published study in JAMA.
This analysis illustrates an 80% survival rate for SickKids patients
utilizing our protocol. In contrast only a 50% survival rate is
achieved by a widely used standard protocol exercised in most
other countries in Europe and the US. Our protocol has become
the preferred modality for treatment of severe combined
immunodeficiency when full HLA matched related donor is not
available. Our scientific and clinical achievements lead to much
recognition. This includes membership by Dr. Roifman in the
World Health Organization Scientific Committee for Clinical
Immunology, which defines the classification of PIDs. Similarly we
contributed to the Manual of Clinical Laboratory Immunology
detailing the process of diagnosing a primary immunodeficiency.
Research remains a major focus of activity in the division.
Dr. Roifman’s laboratory continues to innovate anti-cancer
treatments. Novel compounds were designed against targets in
solid tumours which have lead to significant tumor shrinkage in
vitro and in vivo. Moreover, since Dr. Roifman’s lab synthesized
CR4, another novel compound capable of killing acute lymphocytic
leukaemia (ALL) and acute myeloid leukaemia (Blood 2003), it is
currently being given to patients with ALL in a phase one clinical
study conducted by LymphoSign. The role of Eph receptors in
the immune system is gaining recognition with our recent
publication in the Journal of Immunology. Meanwhile the discovery
of a genetic aberration in the RNA component of RMRP has
initiated testing of patients for this defect (JACI 2006).
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
57
Dr. Grunebaum and his group have successfully developed
and described a novel method to efficiently deliver full length
enzymes such as Purine Nucleoside Phosphorylase (PNP) into
cells. (J Clin Invest, 2006). To further this endeavour his
laboratory continues to develop safer methods of inserting
genes into bone marrow cells. This will facilitate therapy
for diseases such as PNP and Adenosine Deaminase (ADA)
deficiency, while improving the substandard outcomes for
these patients.
In view of his academic achievements and his multiple contributions to clinical immunology in Canada the CI Society created
the Chaim Roifman Scholar Award. Launching in 2007, the
recipients of this research grant will study the clinical, cellular
and molecular characteristics of genetically determined immunodeficiency diseases, discover improved diagnostic tools for PID,
research novel therapeutic approaches for PID or advance
education of patients and medical professionals on PIDs.
Education remains an important activity of every member of the
division. The tireless dedication of our staff to teaching has
recently been fully recognized by the full approval of reviewers
from the Royal College of Physicians and Surgeons. Beyond
this program we continue to attract more than 25 outstanding
candidates every year from across the world. International trainees
have the opportunity to participate in a flexible program which can
be predominantly research oriented. Our commitment to education
goes beyond the training program.
Dr. Roifman organized and chaired the JMF anniversary scientific
program and together with Dr. Grunebaum organized the CI
Society/Canadian Society of Allergy and Clinical Immunology
conference in Edmonton. In addition Dr. Adelle Atkinson was
granted the CI Society physician’s awareness award for a third
consecutive year. Similarly Brenda Reid was presented with a
nursing education grant by the CI Society for her leadership in
the teaching of PID care to nurses globally.
From the common cold to cancer, the clinical applications and
research potential of immunology converge with almost every
aspect of patient care. Thanks to the support of The Donald
& Audrey Campbell Chair, the Jeffrey Modell Foundation, the
CI Society, Canadian Institute of Health Research, March of
Dimes, and the Canadian Centre for Primary Immunodeficiency,
children in our division will receive the best care possible, as
soon as possible.
HONOURS AND AWARDS
Atkinson A: Physicians Awareness Initiative,
Canadian Immunodeficiency Society, 2006.
Reid B: Nurses Awareness Initiative, Canadian
Immunodeficiency Society, 2006.
Roifman CM: Schwartz-Reisman Israel Scholar,
2007.
PUBLICATIONS
Alexander RT, Grinstein S: Na+/H+ exchangers
and the regulation of volume. Acta Physiologica
2006: 187: pp 159-167.
Alexander RT, Malevanets A, Durkan AM, Kocinsky
HM, Aronson PS, Orlowski J, Grinstein S:
Membrane curvature alters the activation kinetics
of the epithelial Na+/H+ exchanger, NHE3.
The Journal of Biological Chemistry 2007: 282:
pp 7376-7384.
58
DEPARTMENT OF PAEDIATRICS
AL-Jenaidi F,Outi M’ekitie O, Grunebaum E,
Sochett E: Parathyroid gland dysfunction in
22q11.2 deletion syndrome. Hormone Research
2007: 67: pp 117-122.
AL-Zahrani, Grunebaum E, Roifman CM: Safety
and efficacy of measles-mumps-rubella vaccine in
patients with DiGeorge/22q11 microdeletion
syndrome. Pediatric Academic Society 2007: 61:
p e6293.14
Aoki CA, Roifman CM, Lian ZX, Bowlus CL,
Norman GL, Shoenfeld Y, Mackay IR, Gershwin E:
IL-2 receptor alpha deficiency and features of
primary biliary cirrhosis. Journal of Autoimmunity
2006: 27: pp 50-53.
ANNUAL REPORT 2006-07
Atkinson A, Zhang J, Quintal L, Williams B,
Grunebaum E, Roifman CM: Novel RAG1 mutation
in a case of severe combined immunodeficiency.
Allergy, Asthma and Clinical Immunology 2006:
2: p 164.
Candotti F, Roifman CM, Puck JM: Injecting some
safety into SCID gene therapy. Gene Therapy
2006: 13: pp 741-743.
Carcao M, St Louis J, Poon MC, Grunebaum E,
Lacroix S, Stain AM, Blanchette VS, Rivard GE:
Rituximab for congenital haemophiliacs with
inhibitors: a Canadian experience. Haemophilia
2006: 12: pp 7-18.
Corbett-Nelson EF, Marshall JG, Grinstein S:
Signalling-dependent immobilization of acylated
proteins in the inner monolayer of the plasma
membrane. The Journal of Cell Biology 2006: 174:
pp 255-265.
Freywald A, Sharfe N, Miller CDE, Rashotte C,
Roifman CM: EphA receptors inhibit anti CD3
induced apoptosis in thymocytes. The Journal of
Immunology 2006: 176: pp 4066-4074.
Grunebaum E, Atkinson A, Reid B, Roifman CM:
Bone marrow transplantation from unrelated
donors for severe combined immune deficiency.
Allergy, Asthma and Clinical Immunology 2006:
2: p 164.
Husain M, Grunebaum E, Naqvi A, Atkinson A,
Ngan BY, Aiuti A, Roifman CM: Burkitt lymphoma
in adenosine deaminase deficient-severe
combined immunodeficiency treated with
polyethylene glycol-adenosine deaminase. Journal
of Pediatrics 151: pp 93-95
Huynh KK, Eskelinen EL, Scott CC, Malevanets A,
Saftig P, Grinstein S: LAMP proteins are required
for fusion of lysosomes with phagosomes.
The EMBO Journal 2007: 26: pp 313-324.
Grunebaum E, Atkinson A, Reid B, Roifman CM:
Bone marrow transplantation from matched
unrelated donors for patients with severe
combined immune deficiency. Biology of Blood
and Marrow Transplantation 2006: 12 S1: p 122.
Kavadas F, Somech R, Pollanen M, Roifman CM:
Hemophagocytic lymphocytosis in a patient with
T-B+NK severe combined immunodeficiency.
Pediatric Academic Society 2007: 61: p e6286.9.
Grunebaum E, Mazzolari E, Porta F, Dallera D,
Atkinson A, Reid B, Notarangelo LD, Roifman CM:
Bone marrow transplant for severe combined
immune deficiency. JAMA 2006: 295:
pp 508-518.
Lai YH, Gruneabum E, Atkinson A, Cutz E, Roifman
CM: Pulmonary and hepatic disease in a patient
with partial Adenosine Deaminase (ADA)
deficiency. Pediatric Academic Society 2007: 61:
p e6286.5.
Grunebaum E, Roifman CM: Clinical and
immunological features of patients with WHIM
syndrome (Warts, Hypogammaglobulinemia,
Infections and Myelokathexis) with or without
mutations in the CXCR4 gene. Pediatric Academic
Society 2007: 61: p e6286.1.
Lamothe J, Huynh KK, Grinstein S, Valvano MA:
Intracellular survival of Burkholderia cenocepacia
in macrophages is associated with a delay in
the maturation of bacteria-containing vacuoles.
Cellular Microbiology 2007: 9: pp 40-53.
Grunebaum E, Sharfe N, Roifman CM: Human T
cell Immunodeficiency: When signal transduction
goes wrong. Immunologic Research 2006: 35:
pp 117-125.
Grunebaum E, Somech R, Reid B, Atkinson A,
Roifman CM: Survival and immune function in
patients with severe combined immune deficiency
after bone marrow transplantation from matched
unrelated donors. Clinical Immunology 2006:
119S: p S37.
Guggenheim R, Somech R, Grunebaum E,
Atkinson A, Roifman CM: Bone Marrow transplantation for Cartilage-hair-hypoplasia. Bone Marrow
Transplantation 2006: 38: pp 751-756.
Husain M, Aiuti A, Atkinson A, Grunebaum E,
Roifman CM: Long-term enzyme replacement
for adenosine deaminase-defiecient patient –
immune function and outcome. Clinical
Immunology 2006: 119S: p S133.
Husain M, Grunebaum E, Cutz A, Roifman CM:
Respiratory distress and lymphopenia in a
neonate – presenting manifestation of severe
combined immunodeficiency. Clinical Immunology
2006: S119: p e12a.
Husain M, Grunebaum E, Naqvi A, Atkinson A,
Ngan B, Aiuti A, Roifman CM: Burkitt lymphoma in
adenosine deaminase deficient severe combined
immunodeficiency treated with polyethylene glycolADA. Clinical Immunology 2006: S119: p e12b.
Lavine E, Picard C, Casanova JL, Roifman CM:
Cellular and humoral aberrations in a kindred with
IL-1 receptor–associated kinase 4 deficiency.
Journal of Allergy and Clinical Immunology. 2007:
Jun4: pp e1-e3.
Lavine E, Roifman CM: Clinical course and
immunological features of siblings with IRAK-4
deficiency. Pediatric Academic Society 2007: 61:
p e6286.6.
Lee WL, Cosio G, Ireton K, Grinstein S: Role of
CrkII in Fc gamma receptor-mediated
phagocytosis. The Journal of Biological Chemistry
2007: 282: pp 1135-1143.
Liao P, Grunebaum E: Gene therapy for purine
nucleoside phosphorylase deficiency. Federationof-Clinical-Immunology-Societies, San Francisco.
Clinical Immunology 2006: 119: pp S134-135.
Martin-Orozco N, Touret N, Zaharik ML, Park E,
Kopelman R, Miller S, Finlay BB, Gros P, Grinstein
S: Visualization of vacuolar acidification-induced
transcription of genes of pathogens inside
macrophages. Molecular Biology of the Cell 2006:
1: pp 498-510.
Mason D, Mallo GV, Terebiznik MR, Payrastre B,
Finlay BB, Brumell JH, Grinstein S: Alteration of
epithelial structure and function associated with
PtdIns(4,5)P2 degradation by a bacterial
phosphatase. The Journal of General Physiology
2007: 129: pp 267-283.
Mero P, Huang ZY, Kim MK, Schreiber AD,
Grinstein S, Booth JW: Phosphorylationindependent ubiquitylation and endocytosis of Fc
gamma RIIA. The Journal of Biological Chemistry
2006: 281: pp 33242-33249.
Moraes TJ, Plumb J, Martin R, Vachon E,
Cherepanov V, Koh A, Loeve C, Jongstra-Bilen J,
Burrows LL, Grinstein S, Downey GP: Abnormalities
in the pulmonary innate immune system in cystic
fibrosis. American Journal of Respiratory Cell and
Molecular Biology 2006: 34: pp 364-374.
Nicolay U, Kiessling P, Berger M, Gupta S,
Roifman CM, Gardulf A, Eichmann F, Haag S,
Massion C, Ochs H: Health-related quality of life in
patients with primary immunodeficiencies in North
America receiving subcutaneous IgG self-infusions
at home. Journal of Clinical Immunology 2006:
26: pp 65-72.
Notarangelo L, Casanova JL, Conley ME, Chapel
H, Fischer A, Puck J, Roifman CM, Seger R, Geha
RS: Primary immunodeficiency diseases: An update
from the International Union of Immunological
Societies primary immunodeficiency diseases
classification committee meeting in Budapest,
2005. Journal of Allergy and Clinical Immunology
2006: 117: pp 883-896.
Roifman CM, Gu Y, Cohen A: Mutations in the RNA
component of Rnase MRP cause Omenn
Syndrome. Journal of Allergy and Clinical
Immunology 2006: 117: pp 897-903.
Smith AC, Heo WD, Braun V, Jiang X, Macrae C,
Casanova JE, Scidmore MA, Grinstein S, Myer T,
Brumell JH: A network of Rab GTPases controls
phagosome maturation and is modulated by
Salmonella enterica serovar typhimurium. The
Journal of Cell Biology 2007: 176: pp 263-268.
Somech R, Grunebaum E, Roifman CM: Short
lived antibody response as a manifestation of
primary immunodeficiency. Pediatric Academic
Society 2007: 61: p e6286.2.
Somech R, Roifman CM: A novel syndrome of
severe immunodeficiency, gonadal dysgenesis
and cardiac defect. Clinical Immunology 2006:
S119: p e9.
Somech R, Roifman CM: Different phenotypes of
profound T cell immunodeficiency associated
with Rnase MRP mutations in cartilage hair
hypoplasia patients. Clinical Immunology 2006:
119S: p S137.
Steinberg BE, Scott CC, Grinstein S: Highthroughput assays of phagocytosis, phagosome
maturation and bacterial invasion. American
Journal of Physiology Cell Physiology 2007: 292:
pp 945-952.
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
59
Steinberg BE, Touret N, Vargas-Caballero M,
Grinstein S: In situ measurement of the electrical
potential across the phagosomal membrane using
FRET. Contribution to the proton-motive force.
Proceedings of the National Academy of Sciences
of the United States of America 2007: 104:
pp 9523-9528.
Suh CI, Stull ND, Li XJ, Tian W, Price MO,
Grinstein S, Yaffe MB, Atkinson S, Dinauer MC:
The phosphoinositide-binding protein p40phox
activated the NADPH oxidase during Fcg IIA
receptor-induced phagocytosis. The Journal of
Experimental Medicine 2006: 203: pp 1915-1925.
Tabeta K, Hoebe K, Janssen EM, Du X, Georgel P,
Crozat K, Mudd S, Mann N, Sovath S, Goode J,
Shamel L, Herskovits AA, Portnoy DA, Cooke M,
Tarantino LM, Wiltshire T, Steinberg B, Grinstein S,
Beutler B: 3d, a missense mutation that disrupts
exogenous antigen presentation and signaling via
Toll-like receptors 3, 7, and 9. Nature Immunology
2006: 7: pp 156-164.
Tan T, Lee W, Alexander DC, Grinstein S, Liu J: The
ESAT-6/CFP-10 secretion system of Mycobacterium
marinum modulates phagosome maturation.
Cellular Microbiology 2006: 8: pp 1417-1429.
Toro A, Grunebaum E: TAT-mediated intracellular
delivery of purine nucleoside phosphorylase
corrects its deficiency in mice. Journal of Clinical
Investigation 2006: 116: pp 2717-2726.
Toro A, Paiva M, Ackerley C, Grunebaum E:
Intracellular delivery of purine nucleoside
phosphorylase (PNP) fused to protein transduction
domain corrects PNP deficiency in vitro. Cellular
Immunology 2006: 240: pp 107-113.
Touret N, Grinstein S: Dynamic and functional
characteristics of the phagosomal membrane.
Medecine Sciences Paris 2006: 5: pp 457-458.
Vachon E, Martin R, Plumb J, Kwok V, Vandivier W,
Glogauer M, Kapus A, Chow CW, Grinstein S,
Downey GP: CD44 is a phagocytic receptor.
Blood 2006: 107: pp 4149-4158.
Yan M, Di Ciano-Oliveira C, Grinstein S,
Trimble WS: Coronin function is required for
chemotaxis and phagocytosis in human
neutrophils. The Journal of Immunology 2007:
178: pp 5769-5778
Yeung T, Ozdamar B, Paroutis P, Grinstein S:
Lipid metabolism and dynamics during
phagocytosis. Current Opinion in Cell Biology
2006: 4: pp 429-437.
Yeung T, Terebiznik M, Yu L, Silvius J, Abidi WM,
Philips M, Levine T, Kapus A, Grinstein S:
Receptor activation alters inner surface potential
during phagocytosis. Science 2006: 313:
pp 347-351.
60
DEPARTMENT OF PAEDIATRICS
BOOK CHAPTERS AND PROCEEDINGS
Alexander RT, Grinstein S: Activation of kinases
upon volume changes: role in cellular
homeostasis. In: Cell Volume Regulation:
Contributions to Nephrology (Lang F, ed). Karger
Press, Basel, Switzerland, 2006.
Dalal I, Roifman CM: The immunity of the
newborn. In: UpToDate (Rose BD, ed).
UpToDate, Waltham, MA, 2006.
Roifman CM: Approach to the Diagnosis of Severe
combined immunodeficiency. In: Manual of
Molecular and Clinical Laboratory Immunology,
7th edition (Detrick B, Hamilton RG, Folds JD,
eds). ASM Press, Washington, DC, 2006.
Roifman CM: Human Interleukin-2 Receptor alpha
Deficiency. In: Primary Immunodeficiency
diseases: a molecular and genetic approach
(Ochs HD, Smith CIE, Puck JM, eds). Oxford
University Press, New York, NY, 2007.
FUNDING
A Clincial Study of the Pharmacokinetics.
Efficacy & Safety of Immune Globulin Intravenous
(Human) Omr-IgG-am IGIV in Subjects with
Primaty Immune Deficiency Disease. Roifman CM.
Leading Investigator, Site Principal investigators:
Roberts R, Melamed IR, Moy J, Grunebaum E,
Sussman GL, Chouksey A, Stein M, Wasserman
RL, Levy R, McNeil D, Suez D. FFF Enterprises
($550,000 2006-2008)
Analysis of the Role of Coronin in Neutrophil
Chemotaxis. Grinstein S. Canadian Institute of
Health Research ($549,490 2004-2009)
Canadian Centre for Primary Immunodeficiency.
Roifman CM. Canadian Centre for Primary
Immunodeficiency ($410,000 2003-2007)
Chair of Immunology. Roifman CM. Donald
& Audrey Campbell ($586,000 1998-2006)
CI Society SCID Picnic. Roifman CM. World
Immunodeficiency Society ($4,586 2006)
Correcting purine nucleoside phosphorylase
deficiency by prolonged intracellular enzyme
replacement therapy. Grunebaum E. March of
Dimes ($390,000 2007-2010)
Correcting PNP deficiency by intracellular delivery
of PNP fused to protein transduction domains.
Grunebaum E. US Immunodeficiency Network
($330,000 2006-2008)
Correcting purine nucleoside phosphorylase using
lenti-virus mediated human PNP gene delivery
into haematopoietic stem cells. Grunebaum E.
SickKids Foundation and the Institute of Human
Development, Child and Youth Health,
Canadian Institute of Health Research ($130,000
2006-2008)
ANNUAL REPORT 2006-07
Dual Role of CD36 in Macrophages:
Atherosclerosis and Immune Responsiveness.
Grinstein S. The Heart and Stroke Foundation
($323,804 2006-2010)
Fellowship in Immunology. Roifman CM.
Canadian Friends of Tel Aviv University ($55,000
2006-2007)
Genetics of Primary Immunodeficiency.
Roifman CM. Canadian Immunodeficiency Society
($100,000 2007-2010)
Home Immunoglobulin Therapy. Roifman CM.
Canadian Immunodeficiency Society ($430,000
2007-2011)
Human Blood Monocyte Receptor Expression
Modulation. Grinstein S. National Institutes of
Health ($500,000 2006-2011)
Imaging Facility Multi-User Maintenance.
Grinstein S. Canadian Institutes of Health
Research ($464,225 2005-2010)
Immunology and Transplantation. Roifman CM.
McMillan Binch Barristers and Solicitors
($75,000 2002-2007)
Jeffrey Modell Research Laboratories for the
diagnosis of primary immunodeficiencies.
Roifman CM. Jeffrey Modell Foundation
($321,000 2001-2009)
Molecular basis of primary immunodeficiency.
Roifman CM. Jeffrey Modell Foundation
($250,000 2006-2011)
Molecular Mechanisms of Phagocyte Activation.
Grinstein S. Canadian Institutes of Health
Research ($828,800 2006-2011)
Novel synthetic styryl-acrylonitrile inhibitors of
tumour angiogenesis: In vivo translation.
Roifman CM. Ontario Cancer Research Network
($512,179 2004-2007)
Pathogenesis of Immune Malignancies.
Roifman CM. Audey Stanleigh Leukemia Research
Foundation ($52,500 2005-2008)
Primary Immunodeficiency (PID) Registry.
Roifman CM. Canadian Blood Services/Bayer Inc.
($194,150 2004-2008)
Retrovirus gene therapy for primary
immunodeficiency diseases. Grunebaum E.
Jeffrey Modell Foundation ($11,000 2006-2007)
Role of Eph receptors in the immune system.
Roifman CM. Canadian Institutes of Health
Research – 2nd renewal ($350,000 2004-2007)
Targeting and Regulation of Ion Transporters.
Grinstein S. Canadian Institutes of Health
Research ($804,500 2004-2009)
Infectious Diseases
DIVISIONAL OVERVIEW
The Division of Infectious Diseases is a leader in clinical,
educational and research activities locally, nationally and
internationally. The division has active inpatient as well as
ambulatory consultant services that include teams that focus on
general infectious diseases and infectious diseases in
immunocompromised hosts, respectively. We are a resource for
issues related to infectious disease outbreaks, including new
and emerging infectious, infection control and the specialized
areas of HIV, congenital infections, management of infectious
complications or organ transplantation, and the ever-increasing
problem of multi-drug resistant tuberculosis.
Division members have a leading role in national and international
epidemiological, clinical, research advisory and related
committees (e.g., the Infectious Diseases Society of America,
the Canadian Paediatric Society, Health Canada, the American
Society for Transplantation, the Government of the Bahamas
and the HIV/AIDS program in Russia).
Our research initiatives are structured around themes that include
host susceptibility and related factors and innovative antimicrobial
and associated therapies. Specific research initiatives include
multicentered paediatric HIV studies related to maternal-to-child
transmission and studies on new antiretrovirals, vaccine studies
and research into the mechanisms of host susceptibility to viral
infections. These infections include viral myocarditis, influenza
illness, HIV, EBV-related post-transplant lympoproliferative disease
(PTLD) and encephalitis. Multicentered trials related to the
diagnosis and prevention of infections in transplant patients are
ongoing, as well as participation in national surveillance studies
Division Head
Dr. Upton D. Allen
Dr. Dat Tran
Dr. Valerie Waters
Full-Time
Dr. Sean Ari Bitnun
Dr. E. Lee Ford-Jones
Dr. Anne G. Matlow
Dr. Anne Opavsky
Dr. Stanley E. Read
Part-Time
Dr. Ian Kitai
Dr. Alana Rosenthal
Dr. Anupma Wadhwa
Cross-Appointees
Dr. Susan Richardson
Dr. Elaine Wang
Honorary
Dr. Ronald Gold
Dr. Susan King
Clinical Fellows
Dr. Mohammed
Al-Ayed
Dr. Kahlid Al Hinai
Dr. Walaa Al-Mansouri
Dr. Abdul Al-Odayani
(IMPACT) and national collaborative paediatric studies through the
Paediatric Investigators Collaborative Network on Infections in
Canada (PICNIC). Our research in infection control includes the
clinical and molecular epidemiology of paediatric nosocomial
infections. The division has continued to have a leadership role in
structuring the approach to the management of major emerging
and resurgent infectious disease threats. In this regard, the division
has been very actively involved in influenza pandemic planning
efforts at SickKids as well as provincially and nationally.
In the area of education, representatives from our division
continue to play a key role in activities of the Royal College of
Physicians and Surgeons of Canada, and in many areas
of undergraduate, graduate and post-graduate and continuing
medical education activities.
Faculty members continue to hold editorships, visiting
professorships and related academic honours nationally and
internationally. In addition, one of our faculty members, Dr. FordJones received the Claus Wirsig Humanitarian Award in 2007.
Dr. Mohammed
Al-Shehri
Dr. Shalini Desai
Dr. Spenta Kakalia
Dr. Kaeda Ota
Dr. Wanatpreeya
Phongsmart
Dr. Ashley Roberts
Research Fellows
Dr. Abdulkader Al-Rezqi
Dr. Jason Brophy
Dr. Michelle
Barton-Forbes
Dr. Michael Hawkes
Helen Heurter
Sharon Li
Brenda O’Doherty
Jennifer Ponsonby
Asad Sabah
Kim Simpson
Laura-Lee Tannis
Research Staff
Nasser Khodai Booran Clinical Nurses
Cathy Den Hollander Debra Louch
Georgina MacDougall
Pat Malloy
Administrative Staff
Brenda Bishop
Toula Myriklis
Zita Rotar
Bebi Wali
Sue Weller
HONOURS AND AWARDS
Allen U: Visiting Professor and External Examiner,
University of West Indies, Jamaica (with site
visits to Jamaica, Bahamas, Barbados and
Trinidad), 2007.
Allen U: Full Professorship, Departments of
Paediatrics and Health Policy Management and
Evaluation, University of Toronto, 2007.
Allen U: Plenary Symposium Chair, Infections after
transplantation, International Pediatric Transplant
Association, Cancun, Mexico, March 2007.
Allen U: Symposium Chair, New Antimicrobial
Therapeutics, Paediatric Academic Societies,
Toronto, May 2007,
Bitnun A: PERLs Resident Teaching Award, 2007.
Ford-Jones L: Proposal and initiation of the Royal
College of Physicians and Surgeons of Canada
CanMEDS Competencies Award for SickKids
Residents and Subspecialty Trainees, 2007.
Ford-Jones L: Claus Wirsig Humanitarian Award,
The Hospital for Sick Children, 2007.
Ford-Jones L: Convocation Address, George Brown
College, School of Early Childhood Education and
School of Nursing, 2007.
Read SE: Professor Emeritus, University of
Toronto, 2006.
Read SE: Inaugural Professorial Lecture, University
of the West Indies, Nassau Campus, 2007.
PUBLICATIONS
Allen U: Public health Implications of MRSA in
Canada. Canadian Medical Association Journal
2006: 175: p 161.
Drs. Ari Bitnun and Ian Kitai with trainees and nursing staff
Allen U and the Infectious Diseases and
Immunization Committee, Canadian Paediatric
Society (CPS): Antimicrobial products in the
home: The evolving problem of antibiotic
resistance. Paediatrics & Child Health 2006:
11: pp 69-173.
Allen U and the Infectious Diseases and
Immunization Committee, Canadian Paediatric
Society (CPS): Current Management of herpes
simplex virus infection in pregnant women and
their newborn infants. Paediatrics and Child
Health 2006: 11: pp 363-365.
Allen U, Aoki F, Stiver G: Influenza
chemoprophylaxis and therapy: Recommended
Guidelines for Practitioners. Paediatrics and Child
Health 2006: 11: pp 520-522.
Allen U, Aoki F, Stiver G: Influenza
chemoprophylaxis and therapy: Recommended
Guidelines for Practitioners. The Canadian Journal
of Infectious Diseases and Medical Microbiology
2006: 17: pp 273-284.
Allen U and the Infectious Diseases and
Immunization Committee, Canadian Paediatric
Society (CPS): Pandemic influenza and Canada’s
children. Paediatrics & Child Health 2006: 11:
pp 335-337.
Allen U and the Infectious Diseases and
Immunization Committee, Canadian Paediatric
Society (CPS): Control and treatment of
methicillin-resistant Staphylococcus aureus in
Canadian paediatric healthcare institutions.
Paediatrics & Child Health 2006: 11: pp 163-165.
Allen U and the Infectious Diseases and
Immunization Committee, Canadian Paediatric
Society (CPS): Community-associated methicillinresistant Staphylococcus aureus: Implications for
the care of children. Paediatrics & Child Health
2007: 12: pp 323-324.
Allen U and the Infectious Diseases and
Immunization Committee, Canadian Paediatric
Society (CPS): Maternal infectious diseases,
antimicrobial therapy or immunizations: Very few
contraindications to breastfeeding. Paediatrics
& Child Health 2006: 11: pp 490-491.
Barton-Forbes M, Hawkes M, Moore D, Conly J,
Nicolle L, Allen U, Boyd N, Embree J, Van Horne L,
LeSaux N, Richardson S, Moore A, Tran D, Waters
V, Vearncomve M, Katz K, Weese JS, Embil J,
Ofner-Agnostini M, Ford-Jones EL: The Writing
Group of Canadian Infectious Disease, Infection
Prevention and Control; and Public Health
Specialists, Guidelines for the prevention and
management of community-associated methicillinresistant Staphylococcus aureus (CA-MRSA):
A perspective for Canadian Health Care
Practitioners. Canadian Journal Infectious
Diseases and Microbiology 2006: 17: pp 4C-24C.
Bitnun A, Roberts A, McGeer A, Tran D, Yau Y,
Simpson K, Green K, Lowe D, Ford-Jones E and
the Toronto Invasive Bacterial Diseases Network:
Laboratory-confirmed influenza-associated
requiring hospitalizations among children in the
metropolitan Toronto and Peel region by active
surveillance, 2004-2005. Canada Communicable
Disease Report 2006: 32: p 19.
Brophy J, Yau Y, Cox P, Katz K, Bitnun A: A sentinel
fatal paediatric case of community-associated
methicillin-resistant Staphylococcus aureus in
Canada. Paediatrics and Child Health 2007: 12:
pp 319-322.
Doja A, Bitnun A, Ford-Jones EL, Richardson S,
Tellier R, Petric M, Heurter H, MacGregor D:
Pediatric Epstein-Barr encephalitis; a 10 review.
Journal of Child Neurology 2006: 21: pp 385-391.
Elbers J, Bitnun A, Richardson SE, Ford-Jones L,
Tellier R, Wald R, Petric M, Kolski H, Heurter H,
MacGregor D: Childhood herpes simplex
encephalitis: A 12-year prospective study of
childhood herpes simplex encephalitis: Is there
a broader spectrum of disease? Paediatrics
2007: 119: p e399.
Flicker SE, Skinner HR, McClelland A, Saulnier P,
Read S, Goldberg E: Supposed to make you
better but it doesn’t really: HIV-positive youths’
perceptions of HIV treatment. Journal of
Adolescent Health 2006: 38: pp 261-267.
Hawkes M, Barton-Forbes M, Conly J, Nicolle L,
Barry C, Ford-Jones EL: Superbug at our doorstep.
Canadian Medical Association Journal 2007: 176:
pp 54-56.
Hernandez De Mezerville M, Tellier R, Herbert D,
Doyle J, Allen U: Adenovirus in paediatric
transplant recipients: A hospital-based study.
Paediatric Infectious Diseases Journal 2006: 25:
pp 815-818.
Kam A, Ford-Jones EL, Malloy P, Kitai I:
Adolescent tuberculosis: Multi-focal involvement
and delay in diagnosis. A 5 year experience from
The Hospital for Sick Children, Toronto, Canada,
1999-2004. Paediatric Infectious Diseases
Journal 2007: 26: pp 355-356.
Kylat RI, Kelly EN, Ford-Jones EL: Clinical findings
and adverse outcome in neonates with congenital
CMV infection. European Journal of Paediatrics
2006: 165: pp 773-778
Maclean JE, Mahant S, Bitnun A, Read S, Capra
M, Solomon M: Worlds apart – the different faces
of childhood HIV. Paediatrics & Child Health
2006: 42: pp 739-742.
Maclean JE, Mahant S, Bitnun A, Read S, Capra
M, Solomon M: Family matters: A twelve-year-old
male with respiratory symptoms, cachexia and
clubbing. Paediatrics & Child Health 2006: 42:
pp 739-742.
Maekawa Y, Ouzounian M, Opavsky A, Liu PP:
Connecting the missing link between dilated
cardiomyopathy and viral myocarditis: Virus
Cystoskeleton and Innate Immunity-Circulation
2007: 115: pp 5-8.
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
63
Matlow AG, Wishen A, Read SE, Raboud JM: A
study of provider-caregiver communication in
paediatric ambulatory care. Paediatrics & Child
Health 2006: 11: pp 217-221.
Moore DL, Vandry W, Scheifele DW, Halperin SA,
Dery P, Ford-Jones E, Law BJ. Lebel M, Le Saux N,
Grimsrud K, Tam T: Surveillance for influenza
admissions among children hospitalized in
Canadian immunization monitoring program active
centres, 2003-2004. Paediatrics 2006: 118:
pp e610-e611.
Roberts A, Bitnun A, McGeer A, Tran D, Yau Y,
Simpson K, Green K, Lowe D, Kawa B, Ford-Jones
EL, and the Toronto Invasive Bacterial Disease
Network: Laboratory-confirmed influenzaassociated hospitalizations among children in the
metropolitan Toronto and Peel region by active
surveillance. Canadian Communicable Disease
Report 2006: 32: pp 203-207.
Rosenthal A, White D, Churilla S, Brodie S, Katz K:
Surveillance culture sites in newborns to optimize
detection of methicillin-resistant Staphylococcus
aureus. Journal of Clinical Microbiology 2006: 44:
pp 4234-4236.
Salter R, King SM, Smith ML, Bitnun A, Brophy J,
Fernandes-Penney A, Lefebvre A, Louch D,
MacDougall G, Moore W, Read SE: Disclosing HIV
diagnosis to infected children: A health care
team’s approach. Vulnerable Children & Youth
Studies Journal 2007: 2: pp 12-16.
Saunders A, Panaro L, McGeer A, Rosenthal A,
White D, Willey BM, Gravel D, Bontovics E, Yaffe
B. Katz K: An outbreak of methicillin-resistant
staphylococcus aureus (MRSA) among healthy
newborns and their mothers. Canadian Journal of
Infectious Diseases and Medical Microbiology
2007: 18: pp 128-132.
64
DEPARTMENT OF PAEDIATRICS
Schuh S, Lalani A, Allen U, Manson D, Babyn P,
Stephens D, MacPhee S, Mokanski M, Kahikin S,
Dick P.: Evaluation of the utility of radiography
in acute bronchiolitis. Journal of Pediatrics 2007:
150: pp 429-433.
Tjon J, Lam W, Seto W, Dekker A, Wong C, Atenafu
E, Bitnun A, Waters V, Yau Y, Solomon M, Ratjen
F: Pharmacokinetic modeling of a once-daily
dosing regimen for intravenous tobramycin in
paediatric cystic fibrosis patients. Journal of
Antimicrobiology and Chemotherapy 2007: 59:
pp 1135-1140.
Walsh CM, Morris SK, Brophy J, Hiraki L,
Richardson S, Allen U: Disseminated
blastomycosis in an infant: A case report and
review of the literature. Pediatric Infectious
Diseases Journal 2006: 25: pp 656-658.
Waters VJ, Gomez MI, Soong G, Amin S, Ernst R,
Prince A: Immunostimulatory properties of the
emerging pathogen Stenotrophomonas
maltophilia. Infectious Immunology 2007: 75:
pp 1698-1703.
Waters VJ, Ratjen F: Multidrug-resistant organisms
in cystic fibrosis: Management and infection
control issues. Expert Review Anti-Infective
Therapy 2006: 4: pp 807-819.
Waters VJ, Sokol S, Reddy B, Soong G, Chun J,
Prince A: The effect of cyclosporine on airway
cell proinflammatory signaling and pneumonia.
American Journal of Respiratory, Cellular
and Molecular Biology 2006: 33: pp 138-144.
Wadhwa A, Lingard L: A qualitative study
examining tensions in interdictor telephone
consultations. Medical Education 2006: 40:
pp 759-767.
ANNUAL REPORT 2006-07
BOOKS AND BOOK CHAPTERS
Liu P, Fuse K, Chu G, Liu Y, Opavsky A: Recent
insights into the role of host innate and acquired
immunity responses. In: Ernst Schering Research
Foundation Symposium Proceedings (Schultheiss
H-P, Kapp J-F, Grötzbach G, eds). Springer, Berlin,
2006.
Lynk DA, Kernested DL, Ford-Jones EL: Young
infants in child care: In: Infection Control in the
Child Care Centre and Pre-School, 7th Edition
(Donowitz L, ed). Williams and Wilkins,
Philadelphia, 2006.
FUNDING
A 48-week, phase II non-comparative, open-label
multicentre study to evaluate the safety,
tolerability, pharmacokinetics and antiviral activity
of GW-433908/Ritnovir BID in HIV-infected
children. Read SE, Bitnun A. GlaxoSmith Kline
($40,000 2004-2006)
A multicenter, double-blind, randomized, placebocontrolled, dose-ranging trial evaluating the safety
and efficacy of RI-001 (RespImmune/RSV-IVIG) in
respiratory syncytial virus (RSV) infected patients
at risk of severe RSV illness. Allen U and ADMA
001 Study Group (Allen U, PI for international
study) ADMA Biologics (estimated $500,000
2007 internationally)
A phase II, open-label trial, to investigate
pharmacokinetics, safety, tolerability and antiviral
activity of TMC 114/rtv b.i.d. in treatmentexperienced HIV-1 infected children and
adolescents. Bitnun A, Read S. Tibotec ($6,675
2006-2007)
A pilot study of genetic determinants of severe
influenza in children. Tran D, Paterson A, Beyene
J, Schuh S, Richardson S. SickKids Research
Institute ($33,800 2006-2007)
A pilot study of genetic determinants of severe
influenza in children. Tran D, Paterson A, Beyene
J, Schuh S, Richardson S. Dean’s Fund New
Staff Grant, University of Toronto ($10,000
2007-2008)
IMPACT Meningococcal Surveillance Program
(January 1, 2007-December 31, 2007)
Scheifele D, Halperin S, Ford-Jones L. Public
Health Agency Canada Canadian Paediatric
Society ($11,662 2007)
Case control study of a pertussis outbreak in
Toronto from October 2005-March 2006. Waters
V, Ford-Jones L, Richardson S, Finkelstein M,
Halperin S. Sanofi Pasteur ($80,000 2006-2007)
Immunization Monitoring Practices Active
(IMPACT) Program. Scheifele D, Halperin S,
Ford-Jones L. Public Health Agency of
Canada/Canadian Paediatric Society
($55,193 2007)
Case control study of a pertussis outbreak in
Toronto from October 2005-March 2006.
Waters V, Ford-Jones L, Richardson S, Finkelstein
M, Halperin S. Ontario Ministry of Health and
Long-Term Care ($23,924 2006)
Defining the role of Stenotrophomonas
maltophilia in CF patients. Waters V, Yau Y.
Bickell Foundation ($64,976 2007)
Defining the role of Stenotrophomonas
maltophilia in CF patients. Waters V, Yau Y.
SickKids Summer Research Program
($2,000 2007)
Defining the role of Stenotrophomonas
maltophilia in CF patients. Waters V, Yau Y.
SickKids Research Institute ($15,000
2006-2007)
Heart failure and the Coxsackie-Adenovirus
Receptor (CAR): Insights through a novel heart
targeted CAR transgenic mouse. Opavsky A.
Heart and Stroke Foundation of Ontario
($278,151 2007-2010)
Mitochondrial DNA Damage in Infants exposed to
HIV Antiretroviral Drugs in Utero. Cote H. Forbes J,
Money D, Burdge D, Harrigan R, Bitnun A,
Read S. Canadian Institutes of Health Research
($267,915 2006-2008)
Multidose, open label randomized safety and
pharmacokinetic study of Tipranivir in combination
with low-dose Ritnovir in HIV infected paediatric
patients. Read S, Bitnun A. Boehringer Ingelheim
($30,000 2004-2006)
Night float: A qualitative evaluation of residents’
perceptions. Hall S, Ladhani M, Wadhwa A.
McMaster Children’s Hospital Paediatric
Residency Research Grant ($2,380 July 2006)
Omega 3 fatty acid supplementation on
hypertriglyceridemia in HIV-infected children
taking Highly Active Antiretroviral Therapy
(HAART): A randomized cross-over study.
Read S, Bitnun A, Brophy J. Physicians’ Services
Incorporated Foundation ($32,000 2007)
Immunogenicity of the 7-valent conjugate
penumococcal vaccine in HIV-infected children.
Bitnun A, Alllen U, Read S. Physicians’ Services
Incorporated Foundation ($16,000 2007-2008)
Positive youth project capacity building grant.
Canadian AIDS treatment information exchange.
Flicker S, Read S, Goldberg E, Skinner H, Veinot T,
Taylor D, McClellan A. Ontario HIV Treatment
Network ($25,000 2006-2007)
Impact of oximetry on disposition in acute
bronchiolitis. Schuh S, Freedman S, Coates A,
Parkin P, Allen U, Willan A, Ungar W, DaSilva Z.
Physicians’ Services Incorporated Foundations
($163,000 2007-2009)
Prospective cohort study of genetic variation and
risk of infection in Canadian children with primary
acute myeloid leukemia. Sung L, Beyene J,
Allen U. National Cancer Institutes of Canada
($444,424 2005-2008)
IMPACT program including pneumococcal
surveillance. Scheifele D, Halperin S, Ford-Jones
L. IMPACT centres, Canada (12 children’s
hospitals): Public Health Agency Canada
administered through Canadian Paediatric
Society ($54,110 2006-2007)
Retrospective study of caspofungin in organ
transplant recipients. Allen U. Merck Canada
($21,000 2006-2007)
RSV Immunoprophylaxis: graduate students
funding support. Allen U, O’Brien K, Simmons B.
Abbott Laboratories ($35,000 2005-2006)
RSV nurse coordinator program. Allen U. Abbott
Laboratories ($65,000 2006-2007)
The Coxsackie-Adenovirus Receptor in heart
infection and heart failure. Opavsky A. Heart
and Stroke Foundation of Ontario ($166,500
2007-2010)
The Coxsackie-Adenovirus Receptor: Function
meets infection in viral myocarditis and dilated
cardiomyopathy. Opavsky A. Heart and Stroke
Foundation of Ontario ($172,014 2005-2007)
The health and economic impact of rotavirus
infection in young children: Retrospective and
prospective study by the Immunization Monitoring
Practices Active (IMPACT) Program. Lesaux N,
Halperin S, Scheifele D, Bettinger, Ford-Jones L,
Waters V, deWals P. IMPACT: Public Health
Agency of Canada ($100,000 2006-2007)
Study of effectiveness of the influenza vaccine to
prevent hospitalization in children 6-23 months of
age during the influenza season 2006-2007.
DeSerres G, Ford-Jones L. Public Health Agency of
Canada ($10,000 2006-2007)
Tuberculosis immunity in childhood. Lewishon D,
Kitai I, Loeffler A. Oregon Health Sciences
University/National Institutes of Health ($11,000
2005-2008)
What makes an excellent clinician in an
Academic Health Sciences Centre? Mahant S,
Wadhwa A. The Hospital for Sick Children
Paediatric Consultants Partnership’s Grant
($8,300 2007)
Division Head
Dr. Keith Tanswell
SICKKIDS
Full-Time
Dr. Jacques Belik
Dr. Jonathan Hellmann
Dr. Andrew James
Dr. Kyong-Soon Lee
Dr. Patrick McNamara
Dr. Aideen Moore
Dr. Hilary Whyte
Part-Time
Dr. Rosemary Moodie
Cross Appointees
Dr. Bonnie Stevens
Adjunct
Dr. Xiaoping Luo
Honorary Faculty
Dr. Max Perlman
Dr. Paul Swyer
MOUNT SINAI HOSPITAL
Dr. Yenge Diambomba
Dr. Ann Jefferies
Dr. Edmond Kelly
Dr. Karel O’Brien
Dr. Arne Ohlsson
Dr. Prakesh Shah
Dr. Vibhuti Shah
Dr. Sharon Unger
Dr. Kin Fan Young Tai
ST. MICHAEL’S
HOSPITAL
Dr. Tony Barozzino
Dr. Douglas Campbell
Dr. Michael Sgro
SUNNYBROOK HEALTH
SCIENCES CENTRE
Full-Time
Dr. Elizabeth Asztalos
Dr. Michael Dunn
Dr. Robert Jankov
Dr. Andrew Shennan
Neonatology
DIVISIONAL OVERVIEW
The Division of Neonatology welcomes Dr. Adrian Ziino to the
Faculty at the Sunnybrook Health Sciences Centre (Women’s
College Hospital site).
The division continues to be well supported by major
funding agencies for its various foci at the three sites, including
lung biology, epidemiology, outcomes-based research and
clinical trials.
Dr. Jonathan Hellmann and NICU staff
The three level III NICUs at The Hospital for Sick Children,
Mount Sinai Hospital and at the Women’s College Hospital site
continue to suffer from a shortage of sufficient level III NICU
beds to adequately meet the maternal and neonatal needs of
our catchment area, which has resulted in regrettable deferrals
of patients out of region, province and country. The Ministry
of Health and Long-Term Care commissioned a Neonatology
Task Force, with province-wide representation including
representatives from the three Toronto NICUs, to address
the issue of current level III NICU bed requirements across the
province, and the predicted increase in requirements over
the next 10-15 years. The report has been delivered to the
Ministry and a response is awaited.
The division’s Neonatal-Perinatal Fellowship Training Programme
was reviewed this year, and received full approval. Dr. Martin
Skidmore, the Programme Director, is to be congratulated on his
dedication and effort. We continue to train the largest number
of subspecialty trainees in Neonatology of any centre in Canada.
Dr. Brian Simmons
Dr. Martin Skidmore
Dr. Adrian Ziino
Part-time
Dr. Shaheen Doctor
Dr. Eugene Ng
Clinical Fellows
Dr. Mudaffer Al-Mudaffer
Dr. Suhair Al-Shanteer
Dr. Ijaz Aman
Dr. Taiba Balkhair
Dr. Rudaina Banihani
Dr. Donna Capili
Dr. Blondel Crosdale
Dr. Amr El Shahed
Dr. Walid El-Naggar
Dr. Emer Finan
Dr. Claudia Garcia Gelvez
Dr. David Gryn
Dr. Omer Hamud
Dr. Doriana Kriguer
Dr. Patricia Lewis
Dr. Zhihau Li
Dr. Pat Mateo
Dr. Askok Mittal
Dr. Marcelo Panzenhagen
Dr. Shilpa Saxena
Dr. Arvind Sehgal
Dr. Sandesh Shivananda
Dr. Niranjan Thomas
Dr. Chris Tomlinson
Dr. Connie Williams
Dr. Jennifer Young
Dr. Meijian Zhao
Research Fellows
Dr. Ben Hur Johnson
Dr. Mandy Lau
Dr. Azar Masoud
Dr. Natasha O’Reilly
Dr. Josh Silver
Dr. Man Yi
Dr. Adrian Ziino
Administrative Staff
Sonia Dos Santos
Ana Granic
Catherine Martin
Jewel Randolph
Jankov RP: Career Development Award, Canadian
Child Health Clinician Scientist Program/Canadian
Institutes of Health Research, 2004-2008.
McNamara PJ: Teacher of the Year Award, Division
of Neonatology, June 2007.
Post M: Canadian Research Chair (Tier 1) in
Fetal, Neonatal & Maternal Health, 2000-2007.
Tanswell AK: Women’s Auxiliary Chair in
Neonatology, 2007.
PUBLICATIONS
Al Nabhani D, Shivananda S, Holtby H, Forte V,
McNamara PJ: The hazardous course of an
end tidal CO2 catheter in a premature infant.
Anesthesiology 2007: 107: pp 180-181.
Aher S, Ohlsson A: Late administration of
erythropoietin for preventing red blood cell
transfusion in preterm and/or low birth weight
infants. The Cochrane Database of Systematic
Reviews 2006: 3: CD004868.
Aher SM, Ohlsson A: Early versus late
erythropoietin for preventing red blood cell
transfusion in preterm and/or low birth weight
infants.The Cochrane Database of Systematic
Reviews 2006: Issue 3: CD004865.
Al-Faleh K, Lee K-S, Ramsay J, Nowaczyk M:
Genetic considerations in recurrent congenital
diaphragmatic hernia in two siblings. Annals of
Saudi Medicine 2006: 26: pp 391-394.
Barton M, Hawkes M, Moore D, Conly J, Nicolle L,
Allen U, Boyd N, Embree J, Van Horne L, Le Saux
N, Richardson S, Moore AM, Tran D, Waters V,
Vearncombe M, Katz K, Weese JS, Embil J, OfnerAgostini M, Lee Ford Jones E: The Writing Group
of the Expert Panel of Canadian Infectious
Disease, Infection Prevention & Control, & Public
Health: Guidelines for the prevention and
management of community-associated methicillinresistant Staphylococcus aureus: A perspective
for Canadian health care practitioners. Canadian
Journal of Infectious Disease & Medical
Microbiology 2006: 17: pp 4C-24C.
Belik J, Kerc E, Pato MD: Rat pulmonary arterial
smooth muscle myosin light chain kinase and
phosphatase activities decrease with age.
American Journal of Physiology – Lung Cellular and
Molecular Physiology 2006: 290: pp L509-L516.
68
DEPARTMENT OF PAEDIATRICS
Belik J, Hehne N, Pan J, Behrens A: Soluble
guanylate cyclase-dependent relaxation is reduced
in the adult bronchial smooth muscle. American
Journal of Physiology – Lung Cellular and
Molecular Physiology 2007: 292: pp L699-L703.
Breau LM, McGrath PJ, Stevens B, Beyene J,
Camfield CS, Finley GA, Franck L, Gibbins S,
Howlett A, McKeever P, O’Brien K, Ohlsson A:
Judgments of pain in the neonatal intensive care
setting: A survey of direct care staffs’ perceptions
of pain in infants at risk for neurological
impairment. The Clinical Journal of Pain 2006:
22: pp 122-129.
Campbell D, Shah PS, Shah V, Kelly E: Nasal
continuous positive airway pressure delivered by
high flow cannula versus infant flow system for
preterm infants – A randomized pilot trial. Journal
of Perinatology 2006: 26: pp 546-549.
Chan A, Jayasuriya K, Berry L, Roth-Kleiner M,
Post M, Belik J: Volutrauma activates the clotting
cascade in the newborn but not adult rat.
American Journal of Physiology – Lung Cellular and
Molecular Physiology 2006: 290: pp L754-L760.
Das A, Shah PS: Octreotide for the treatment of
chylothorax in neonates (Protocol). Cochrane
Database Systematic Reviews 2007: 2:
CD006388.
Davey C, Moore AM: Necrotizing fascitis of the
scalp in the newborn. Obstetrics and Gynecology
2006: 107: pp 461-463.
Deimling J, Thompson K, Tseu I, Wang J, Keijzer R,
Tanswell AK, Post M: Mesenchymal maintenance
of distal epithelial cell phenotype during late fetal
lung development. American Journal of Physiology
2007: 292: L725-L741.
El-Sayed M, Taddio A, Fallah S, de Silva N,
Moore AM: Safety profile of morphine following
surgery in neonates. Journal of Perinatology 2007:
27: pp 444-447.
Epelman M, Daneman A, Navarro OM, Morag I,
Morre AM, Kim JH, Feingold R, Taylor G, Gerstle T:
Necrotizing enterocolitis (NEC): A review of stateof-the-art imaging findings with pathologic
correlation. Radiographics 2007: 37: pp 285-305.
ANNUAL REPORT 2006-07
Fluss J, Blaser S, Chitayat D, Akoury H, Glanc P,
Skidmore M, Raybaud C: Molar tooth sign in fetal
brain magnetic resonance imaging leading to
the prenatal diagnosis of Joubert syndrome and
related disorders. Child Neurology 2006: 21:
pp 320-324.
Godambe S, Newby B, Shah V, Shah PS: Effect
of Indomethacin on Closure of Ductus Arteriosus
in VLBW Neonates after early surfactant. Acta
Paediatrica 2006: 95: pp 1389-1393.
Jankov RP, Kantores C, Belcastro R, Yi M, Tanswell
AK: Endothelin-1 inhibits apoptosis of pulmonary
arterial smooth muscle in the neonatal rat.
Paediatric Research 2006: 60: pp 245-251.
Kantores C, McNamara PJ, Engelberts D,
Kavanagh BP, Jankov RP: Therapeutic hypercapnia
prevents chronic hypoxia-induced pulmonary
hypertension in the newborn rat. American Journal
Physiology – Lung Cellular and Molecular
Physiology 2006: 291: pp L912-L922.
Kaylat RI, Kelly EN, Ford-Jones EL: Clinical findings
and adverse outcome in neonates with
symptomatic congenital cytomegalovirus (SCCMV)
infection. European Journal of Paediatrics 2006:
165: pp 773-778.
Kaylat R, Ohlsson A: Recombinant human
activated protein C for severe sepsis in neonates.
Cochrane Database Systematic Reviews 2006:
2: CD005385.
Koehler DR, Martin B, Corey M, Palmer D, Ng P,
Tanswell AK, Hu J: Readministration of
helper-dependent adenovirus to mouse lung.
Gene Therapy 2006: 13: pp 773-780.
Liao L, Ning Q, Li Y, Wang W, Wang A, Wei W, Liu
X, Auten RL, Tanswell AK, Luo X: CXCR2 blockade
reduces radical formation in hyperoxia-exposed
newborn rat lung. Paediatric Research 2006: 60:
pp 299-303.
Ly LG, Hawes J, Whyte HE, Teixiera LS,
McNamara PJ: The hemodynamically significant
ductus arteriosus in critically ill full-term neonates.
Biology Neonate 2007: 91: pp 206-265.
Magee LA, von Dadelszen P, Chan S, Gafni A,
Gruslin A, Helewa M, Hewson S, Kavuma E, Lee
SK, Logan AG, McKay D, Moutquin J-M, Ohlsson
A, Rey E, Ross S, Singer J, Willan AR, Hannah ME:
The CHIPS (Control of Hypertension in Pregnancy
Study) pilot trial. British Journal of Obstetrics and
Gynaecology 2007: 114: p 770.
Dr. Aideen Moore and NICU team
HONOURS AND AWARDS
Maegawa G, Chitayat D, Blaser S, Whyte H,
Thomas M, Kim P, Kim J, Taylor G, McNamara PJ:
Bilateral microtia with absence of external
auditory meati, fused ossicles and Mondini
dysplasia, duodenal atresia, anal anomalies,
thyroid hemiplasia and bilary atresia. A new
mandibulofacial dysostosis syndrome? Clinical
Dysmorphology 2006: 15: pp 191-196.
Mark H, Yudin MH, Shah V, Ohlsson A, Farine D:
Are we winning the fight against GBS infection?
Obstetrics and Gynaecology 2006: 28:
pp 499-500.
McCaul C, McNamara P, Engleberts D, Slorach C,
Hornberger L, Kavanagh B: Epinephrine increases
mortality after brief asphyxial cardiac arrest in an
in vivo rat model. Anesthesia and Analgesia
2006: 102: pp 542-548.
McCaul C, McNamara PJ, Engleberts D, Slorach C,
Hornberger L, Kavanagh B: The effect of global
hypoxia on myocardial function after successful
cardiopulmonary resuscitation in a laboratory
model. Resuscitation 2006: 68: pp 267-275.
Nadeau K, Jankov RP, Oyewumi L, Tanswell AK,
Sweezey NB, Kaplan F: Lgl1 is suppressed in
oxygen toxicity models of bronchopulmonary
dysplasia and normalizes during recovery in air.
Pediatric Research 2006: 59: pp 389-395.
Shah P, Beyene J, To T, Ohlsson A, Perlman M:
Postasphyxial hypoxic-ischemic encephalopathy in
neonates: Outcome prediction rule within 4 hours
of birth. Archives of Pediatrics & Adolescent
Medicine. 2006: 160: pp 729-736.
Newby B, Cuddy M, Shah V: No infantile
hupertrophic pyloric stenosis among neonates
who received erythromycin for postexposure
prophylaxis against pertussis. Canadian Journal
of Hospital Pharmacy 2007: 60: pp 35-39.
Shah S, Ohlsson A: Ibuprofen for the prevention
of patent ductus arteriosus in preterm and/or low
birth weight infants. Cochrane Database
Systematic Reviews 2006: 1: CD004213.
Oepkes D, Seaward PG, Frank PHA,
Vandenbussche FPHA, Windrim R, Kingdom J,
Beyene J, Kanhai HHH, Ohlsson A, Ryan G, for the
DIAMOND Study Group: Doppler ultrasonography
versus amniocentesis to predict fetal anemia.
New England Journal of Medicine 2006: 355:
pp 156-164.
Ohlsson A, Jacob S: Meta-regression can indicate
if further NIDCAP studies are justified.
Lakartidningen 2007: 104: pp 134-137.
McDonald S, Walker M, Perkins S, Beyene J,
Murphy K, Gibb W, Ohlsson A: The effect of
tobacco exposure on the fetal hypothalamicpituitary-adrenal axis. British Journal of Obstetrics
and Gynaecology 2006: 113: pp 1289-1295.
Palencia R, Gafni A, Hannah M, Willian A, Hewson
S, McKay D, Hannah W, Whyte H, Amankwah K,
Cheung M, Guselle P, Helewa M, Hodnett E, Kung
R, Saigal S: The costs of planned caesarean
versus planned vaginal births in the Term Breech
Trial. Canadian Medical Association Journal 2006:
pp 1109-1113.
McNamara PJ: Non-conventional use of amplitude
integrated electroencephalography (aEEG):
Lessons from a tertiary NICU. Neonatology Today
2007: 2: pp 1-9.
Parvez O, Voss AM, de Kok M, Roth-Kleiner M,
Belik J: Bronchial muscle peristaltic activity
in the fetal rat. Pediatric Research 2006: 59:
pp 756-761.
Moore AM, O’Brien K: Follow-up issues with
multiples. Paediatrics and Child Health 2006: 11:
pp 283-286.
Schmidt B, Roberts RS, Davis P, Doyle LW,
Barrington KJ, Ohlsson A, Solimano A, Tin W, for
the Caffeine for Apnea of Prematurity Trial Group:
Methylxanthine therapy for apnea of prematurity.
New England Journal of Medicine 2006: 354:
pp 212-221.
Morag I, Epelman M, Daneman A, Moineddin R,
Parvez B, Shechter T, Hellmann J: Portal vien
thrombosis in the neonate: Risk factors, course
and outcome. Journal of Pediatrics 2006: 148:
pp 735-739.
70
DEPARTMENT OF PAEDIATRICS
Sgro M, Campbell CM, Shah V: Incidence and
causes of severe neonatal hyperbilirubinemia in
Canada. Canadian Medical Association Journal
2006: 175: pp 587-590.
ANNUAL REPORT 2006-07
Shah PS, Shah N: Heparin bonded catheters for
prolonging the patency of central venous
catheters in children. Cochrane Database
Systematic Reviews 2006: 2: CD005983.
Shah PS, Kalyn A, Satodia P, Dunn M, Parvez B,
Daneman A, Salem S, Glanc P, Ohlsson A, Shah V:
A randomized controlled trial of heparin versus
placebo infusion to prolong the usability of
peripherally placed percutasneous central venous
catheters (PCVCs) in neonates. Paediatrics 2007:
119: pp 284-291.
Shah PS, Siriwardena K, Taylor G, Steele L, Ray P,
Blaser S, Chitayat D: Sudden infant death in
a patient with FGFR3 P250R mutation. American
Journal of Medicine Genetics 2006: 140:
pp 2794-2796.
Shah PS, Shah N: Low molecular weight heparin
for prevention of central venous catheterization
related thrombosis in children. Cochrane Database
of Systematic Reviews 2006: 2: CD005982.
Shah PS, Weksberg R, Chitayat D: Overgrowth with
severe developmental delay following IVF/ICSI –
A new syndrome? American Journal of Medical
Genetics 2006: 140: pp 1312-1315.
Shah PS, Wong KY, Merko S, Bishara R, Dunn MS,
Asztalos E, Darling PB: Postnatal growth failure in
preterm infants ≤ 28 weeks at birth: A measure
of ascertainment that is associated with outcome
at 18-24 months. Journal of Perinatal Medicine
2006: 34: pp 484-489.
Shah PS, Aliwalas LLD, Shah V: Breastfeeding
or breast milk for procedural pain in neonates
(review), Cochrane Database of Systematic
Reviews 2006: 3: CD004950.
Silva CT, Daneman A, Navarro OM, Moore AM,
Moineddin R, Gerstle JT, Mittal A, Brindle M,
Epelman M: Correlation of sonographic findings
and outcome in necrotizing enterocolitis. Pediatric
Radiology 2007: 37: pp 274-282.
Shah V, Farine D, Perlman M: Postnatal laboratory
timers of antenatal hyposcemic-ischemic brain
damage. Journal of Perinatology 2006: 26: p 204.
Shah PS, Kaufman D: Antistaphylococcal
immunoglobulins to prevent staphylococcal
infection in very low birth weight infants. Cochrane
Database of Systematic Reviews 2007: 2:
CD006449.
Smith GN, Walker MC, Ohlsson A, O’Brien K,
Windrim R, for the Canadian Preterm Labour
Nitroglycerin Trial Group: Randomized double-blind
placebo-controlled trial of transdermal nitroglycerin
for preterm labor. American Journal of Obstetrics
and Gynecology 2007: 196: pp 37-38.
Smith RW, Shah V, Goldman RD, Taddio A:
Caregivers’ responses to pain in their children in
the emergency department. Archives of Pediatrics
and Adolescent Medicine 2007: 161: pp 578-582.
Stevens B, Guerriere D, McKeever P, Croxford R,
Miller K-L, Watson-MacDonell J, Gibbins S, Dunn
M, Ohlsson A, Ray K, Coyte P: Economics
of home vs. hospital breastfeeding support for
newborns. Journal of Advanced Nursing 2006:
52: pp 233-243.
Stevens VJ, McGrath P, Yamada J, Gibbins S,
Beyene J, Breau L, Camfield C, Finley A, Franck L,
Howlett A, Johnston C, McKeever P, O’Brien K,
Ohlsson A: Identification of pain indicators
for infants at risk for neurological impairment:
A Delphi consensus study. BMCC Pediatrics
2006: 6: p 1.
Stevens B, McGrath P, Gibbins S, Beyene J,
Breau L, Camfield C, Finley A, Franck L, Howlett A,
Johnston C, McKeever P, O’Brien K, Ohlsson A,
Yamada J: Determining behavioural and
physiological responses to pain in infants at risk
for neurological impairment. Pain 2007: 127:
pp 94-102.
Synnes AR, MacNab Y, Qui Z, Ohlsson A,
Gustafson P, Dean CB, Lee SK, and the Canadian
Neonatal Network: Neonatal intensive care unit
characteristics affect the incidence of severe
intraventricular hemorrhage. Medical Care 2006:
44: pp 754-759.
Taddio A, Lee C, Yip A, Parvez B, McNamara PJ,
Shah V: Intravenous morphine and topical
tetracaine for treatment of pain in neonates
undergoing central line placement. Journal of
the American Medical Association 2006: 295:
pp 793-800.
Hellmann J: Commentary on �Comparison of
mothers’ and counsellors’ perceptions of
predelivery counselling for extremely premature
infants. In: 2006 Yearbook of Neonatal and
Perinatal Medicine (Fanaroff AA, Maisels MJ,
Stevenson DK, eds). Mosby, St. Louis, 2006.
Taddio A, Lee C, Yip A, Parvez B, Shah V: Contact
dermatitis and bradycardia in a preterm
infant given tetracaine 4% gel. Therapeutic Drug
Monitoring 2006: 26: pp 546-549.
Hellmann J: Commentary on �Medical staff
guidelines for periviability pregnancy counselling
and medical treatment of extremely premature
infants’. In: 2006 Yearbook of Neonatal and
Perinatal Medicine (Fanaroff AA, Maisels MJ,
Stevenson DK, eds). Mosby, St. Louis, 2006.
Teixeira L, McNamara PJ: Enhanced intensive
care for the neonatal ductus arteriosus. Acta
Paediatrica 2006: 95: pp 394-403.
Turner D, Zlotkin SH, Shah PS, Griffiths AM:
Omega 3 fatty acids (fish oil) for maintenance of
remission in Crohn’s Disease. Cochrane Database
of Systematic Reviews 2007: 2: pp CD006320.
Vemgal P, Ohlsson A: Interventions for non-oliguric
hyperkalaemia in preterm neonates. The Cochrane
Database Systematic Reviews 2007:
2: p CD005257.
Walsh MC, Yao Q, Horbar JC, Carpenter JH, Lee
SK, Ohlsson A, for the NICHD Neonatal Network
(NRN), Vermont Oxford Network (VON) and
Canadian Neonatal Network (CNN): Paediatrics
2006: 118: pp e1328-e1335.
Yi M, Belcastro R, Shek S, Luo D, Post M,
Tanswell AK: Fibroblast growth factor-2 and
receptor-1_(IIIc) regulate postnatal rat lung cell
apoptosis. American Journal of Respiratory Critical
Care Medicine 2006: 174: pp 581-589.
Yi SL, Kantores C, Belcastro R, Cabacungan J,
Tanswell AK, Jankov RP: 8-isoprostane-induced
endothelin-1 production by infant rat pulmonary
artery smooth muscle cells is mediated by Rhokinase. Free Radical Biology Medicine 2006: 41:
pp 942-949.
Yudin MH, Shah V, Ohlsson A, Farine D: Are we
using the optimal strategy for GBS management
in pregnancy? Are we winning the fight against
GBS infection? Journal of Obstetrics and
Gynaecology of Canada 2006: 28: pp 499-503.
BOOKS AND BOOK CHAPTERS
Hellmann J, Baylis F: Ethics in perinatal and
neonatal medicine. In: Neonatal-Perinatal
Medicine: Diseases of the Fetus and Infant, 8th
Edition (Fanaroff AA, Martin RJ, eds). Mosby, St.
Louis, 2006.
Hellmann J: Commentary on �Prenatal
consultation practices at the border of viability:
A regional survey’. In: 2006 Yearbook of Neonatal
and Perinatal Medicine (Fanaroff AA, Maisels MJ,
Stevenson DK, eds). Mosby, St. Louis, 2006.
Hellmann J: Commentary on �The ethics of
neonatal resuscitation at the margins of viability:
Informed consent and outcomes’. In: 2006
Yearbook of Neonatal and Perinatal Medicine
(Fanaroff AA, Maisels MJ, Stevenson DK, eds).
Mosby, St. Louis, 2006.
Hellmann J: Ethical issues in the Neonatal
Intensive Care Unit (NICU). In: Resident’s
Handbook of Neonatology, 3rd Edition (Kirpalani
H, Moore A, Perlman M, eds). B.C. Decker,
Hamilton, 2007.
Hellmann J: Commentary on �Matters of spirituality
at the end of life in the pediatric intensive care
unit’. In: 2007 Yearbook of Neonatal and Perinatal
Medicine (Fanaroff AA, Maisels MJ, Stevenson DK,
eds). Mosby, St. Louis, 2007.
Hellmann J: Commentary on �Parents’ experiences
of sharing neonatal information and decisions:
Consent, cost and risk’. In: 2007 Yearbook of
Neonatal and Perinatal Medicine (Fanaroff AA,
Maisels MJ, Stevenson DK, eds). Mosby, St.
Louis, 2007.
Hellmann J: Commentary on �Pediatric resident
education in palliative care: A needs assessment’.
In: 2007 Yearbook of Neonatal and Perinatal
Medicine (Fanaroff AA, Maisels MJ, Stevenson DK,
eds). Mosby, St. Louis, 2007.
Hellmann J: Commentary on �Restriction of
ongoing intensive care in neonates: A prospective
study’. In: 2007 Yearbook of Neonatal and
Perinatal Medicine (Fanaroff AA, Maisels MJ,
Stevenson DK, eds). Mosby, St. Louis, 2007.
Lodha M, Moore AM: Gastroenterologic disorders.
In: Resident’s Handbook of Neonatology, 3rd
Edition (Kirpalani H, Moore AM, Perlman M, eds).
B.C. Decker, Hamilton, 2007.
McNamara PJ, Whyte HE: Principles of neonatal
transport. In: Resident’s Handbook of
Neonatology, 3rd Edition (Kirpalani H, Moore A,
Perlman M, eds). B.C. Decker, Hamilton, 2006.
McNamara PJ: The ductus arteriosus. In:
Neonatology at a Glance (Lissauer T, ed).
Blackwell Publishing, Massachusetts, 2006.
McNamara PJ: Cardiac disorders. In: Neonatology
at a Glance (Lissauer T, ed.). Blackwell Publishing,
Massachusetts, 2006.
McNamara PJ: Echocardiography for the
neonatologist. In: Neonatology at a Glance
(Lissauer T, ed). Blackwell Publishing,
Massachusetts, 2006.
FUNDING
Airway modulation of pulmonary vascular tone
during development and following pulmonary
hypertension. Belik J. Canadian Institutes of
Health Research ($110,108 2004-2009)
An integrated, shared data management
application for the Toronto Tri-Hospital Respiratory
Syncyticial Virus Prophylaxis (RSVP) Program.
O’Brien K, Bracht M, Barton P, James AG. Abbott
Laboratories Limited ($50,000 2005-2007)
Moore AM: Commentary on �Institutional Review
Board Guidance on Pediatric Research: Missed
opportunities’. In: 2006 Yearbook of Neonatal and
Perinatal Medicine. Mosby, St. Louis, 2006.
An outcome indicator of morbidity in medically
vulnerable infants. Dick P, Whyte HE,
Guerriere ND, Guttmann A, O’Brien K, To T.
Canadian Institutes of Health Research
($216,976 2003-2006)
Moore AM: Commentary on �Quantifying the
Federal Minimal Risk Standard. Implications for
pediatric research without a prospect of direct
benefit’. Mosby, St. Louis, 2006.
Bone mass and growth following necrotizing
enterocolitis. Moore AM, Ward WE. SickKids
Foundation ($83,236 2004-2006)
Moore AM: Editor, Resident’s Handbook of
Neonatology, 3rd Edition. (Kirpalani H, Moore AM,
Perlman M, eds). B.C. Decker, Hamilton, 2006.
CAP follow up at 5 years. Schmidt B, Roberts R,
Barrington K, Ohlsson A, Solimano A, Davis P,
Doyle L, Tin W. Canadian Institutes of Health
Research ($1,744,740 2005-2009)
Ohlsson A, Shah V: Evidence-based practice as
means for clinical decision making. In: Pain in
Neonates and Infants (Anand KJS, Stevens B,
McGrath PJ, eds). Elsevier, Philadelphia, 2007.
Shah P, Perlman M: Birth asphyxia and multiorgan
dysfunction. In: Recent Advances in Paediatrics.
(David T, ed). The Royal Society of Medicine
Press, UK, 2006.
Shah P, Perlman M: Neurology of newborn. In:
Handbook of Neonatology, 3rd Edition. (Kirpalani
H, Moore AM, Perlman M, eds). B.C. Decker,
Hamilton, 2007.
Shah P: Classification of newborn. In: Handbook
of Neonatology, 3rd Edition. (Kirpalani H,
Moore AM, Perlman M, eds). B.C. Decker,
Hamilton, 2007.
Taddio A, Shah V: Pain management. In:
Handbook of Neonatology (Kirpalani H,
Moore AM, Perlman M, eds). B.C. Decker,
Hamilton, 2007.
Young Tai KF: Infection control in the neonatal
intensive care unit. In: Handbook of Neonatology,
3rd Edition. (Kirpalani H, Moore AM, Perlman M,
eds). B.C. Decker, Hamilton, 2007.
Comparison of multi-media computer disk versus
face-to-face teaching for inhaled nitric oxide set
up in neonates, a randomized controlled trial. Lee
K-S, Gibbins S, Whyte H. The Hospital for Sick
Children Paediatric Consultants Partnership’s
Grant ($5,000 2006)
Continuous infusion of Heparin to prolong the
patency of peripherally placed percutaneous
central venous catheters (PCVC): A randomized
controlled trial. Shah V, Shah PS, Parvez B, Dunn
M, Kalyn A, Daneman A, Ohlsson A. SickKids
Foundation ($129,960 2002-2006)
Early external cephalic version-2 trial. Hutton, EK,
Willan AR, Hannah ME, Gafni A, Ohlsson A,
Barrett J, Ross SJ, Windrim R, Delisle MF,
Carson GD, Dunn MS, Pollard JK, Natale R.
Canadian Institutes of Health Research
($2,853,717 2003-2007)
Effectiveness of sucrose analgesia in reducing
pain responses in infants born to diabetic and
non-diabetic mothers: A randomized controlled
trial. Taddio A, Ohlsson A, Beyene J, Shah V,
Stevens B, Katz J. Canadian Institutes of Health
Research ($455,198 2003-2006)
Efficacy and safety of targeting lower arterial
oxygen saturations to reduce oxygen toxicity and
oxidative stress in very preterm infants: Canadian
Oxygen Trial (COT). Schmidt B., Roberts R, Whyte
R, Azstalos E, Solimano A, Bairam, Chiu A, Clarke
M, Harrold J, Kumar M, Moddemann D, Peliowski
A, Rabi Y, Roukema H, Sauve R, Seshia M, Shah
PS. Canadian Institutes of Health Research
($3,884,860 2006-2011)
Evaluation of topical liposomal lidocaine and oral
sucrose for treatment of pain in newborn infants
undergoing venipuncture: A randomized controlled
trial. Taddio A, Shah V, Katz J, Stevens D,
Koren G. Canadian Institutes of Health Research
($397,450 2007-2009)
Evidence-based practice identification and change
(EPIC). Lee SK, Synnes A, Singhal N, Walker CR,
Aziz K, Ohlsson A, Baker GR, Barrington KJ, Cronin
CM, Hoube J, Langley J, Lee D, Liston R, Macnab
YC, Martin C, Matthew JD, Moehr JR, Newman CJ,
Pellowski A, Platt RW, Pope S, Sankaran K, Seshia
M, Stevens B, Thiessen PN, von Dadelszen P,
Whynot E, Whyte RK. Canadian Institutes of
Health Research ($717,252 2002-2006)
Functional MR Imaging for early detection and
physiologic characterization of inflammatory
arthritis in a rabbit model. Doria SA, Belik, J,
Kassner A, Cheng H-L, Crawley A, Yeung R,
Tomlinson G, Gahunia H. RSNA Research &
Education Foundation ($29,964 2006-2007)
Genome-environment interactions in Type 1
Diabetes. Danska J, MacPherson A, Moore AM.
Genome Canada ($94,127 2005-2009)
Group in lung development. Tanswell AK, Belik J,
Chan A, O’Brodovich H, Post M, Rotin D. Cutz E,
Hu J, Kavanagh B, Otulakowski LG, Yeger H.
Canadian Institutes of Health Research
($1,377,695 2004-2009)
Infant flow biphasic NCPAP vs. infant flow NCPAP
for facilitation of extubation in infants less than
1250 gms: A randomized controlled trial. O’Brien
K, Shah V, Campbell C. Physicians’ Services
Incorporated Foundation ($73,000 2006-2008)
Inhibition of apoptosis as a major component of
chronic neonatal lung injury. Tanswell AK, Jankov
RP. Canadian Institutes of Health Research
($430,045 2007-2012)
INTAPP (International trial of antioxidants for the
prevention of preeclampsia). Fraser W, Xiong X,
Julien P, Thomas N, Magee LA, Ohlsson A.
Canadian Institutes of Health Research
($4,923,447 2002-2007)
Multiple vs. single courses of antenatal
corticosteroids for preterm birth. Murphy KE,
Hannah ME, Ohlsson A, Saigal S, Kelly EN,
Amankwah KS, Matthews SG, Aghajafari F,
Willan A, Dhindsa BL, Gafni A, Hewson S.
Medical Research Council of Canada
($4,799,770 2000-2006)
Multiple courses of steroids – 5 year follow-up.
Asztalos E, Gafni A, Hannah M, Murphy K,
Ohlsson A, ross S, Saigal S, Willan A, Matthews S,
rovet J, Lee S, Amankwah K, Kelly EN, Lee SK,
Delisle M-F, Guselle P, Sananes R. Canadian
Institutes of Health Research ($3,585,161
2005-2012)
Multicentre randomized trial of HeLP (heat loss
prevention) in the delivery room. Vohra S, Reilly
MC, Dunn M, Vincer M, Wiebe N, Zayack D,
Wimmer J. Canadian Institutes of Health
Research ($640,465 2004-2008)
Nasal ventilation in premature infants. Kirpalani H,
Chiu A, Lemyre B, Millar D, Roberts R, Vaillancourt
K, Alvaro R, Connelly R, Howlett A, McNamara P,
Peliowski A, Solimano A, Shah P, Aziz K, Zupancic
J, Meade M. Canadian Institutes of Health
Research ($2,233,100 2006-2009)
National health partnership for reducing infections
in NICU. Lee SK, Aziz K, Baker GR, Barrington K,
Clarke MCW, Cronin CM, Dunn MS, James A,
Langley J, Lee DS, Lefebvre F, Merchant P,
Ohlsson A, Orrbine E, Peliowski A, Sankaran K,
Seshia M, Shaw NT, Synnes AR, Tan-DY CR, Walker
CR, Whyte RK. Canadian Institutes of Health
Research ($99,999 2005-2008)
Novel therapeutic interventions for
bronchopulmonary dysplasia: Targeting oxidants
and growth factors in the newborn rat lung.
Robert P Jankov. Canada Foundation for
Innovation New Opportunities Fund/Ontario
Research Fund ($297,340 2004-2009)
Pharmacology of milrinone in persistent
pulmonary hypertension of the newborn.
McNamara P, Taddio A. The Hospital for
Sick Children – New Ideas Grant ($39,349
2006-2008)
Predicting neurobehavioural outcome in
preterm infants. Taylor M, Whyte HE, Moore AM.
Canadian Institutes of Health Research
($929,910 2007-2012).
Protocol for cerebral function monitoring in the
neonatal intensive care unit (Protocol).
McNamara PJ. Olympic Medical Incorporated
($2,875 2006)
Pulmonetics LTV 1200 mechanical ventilator
use in neonates less than 5 kg. Belik J, Whyte HE.
Pulmonetic Systems Incorporated ($5140.45
2006).
Quality of care ICE (QC-ICE) team in neonatalperinatal care. Lee KS, Baker GR, Langley JM,
MacNab YC, Moehr JR, Ohlsson A, Stevens B,
Magee L, Sauve R, Keller P, Michalos A, Klassen
A. Canadian Institutes of Health Research
($935,000 2003-2007)
Randomized study of Vasopressin vs Epinephrine
in a neonatal model of asphyxial cardiac arrest.
McNamara PJ, Kavanagh BP. American Academy
of Pediatrics, Neonatal Resuscitation Grant
($28,752 2006-2008)
Reactive nitrogen species and smooth muscle
growth regulators in the pathogenesis of newborn
pulmonary hypertension. Jankov RP. Career
Development Award, Canadian Child Health
Clinician Scientist Program/Canadian Institutes
of Health Research ($280,000 2004-2008)
Reactive nitrogen species and macrophages as
mediators of pulmonary hypertension in the
newborn rat. Jancov RP. The Physicians’ Services
Incorporated Foundation ($154,000 2005-2006)
Thyroid hormone and infant visual processing
development. Rovet J, Westall C, Asztalos E.
Canadian Institutes of Health Research
($616,540 2001-2006)
Regulation of normal and oxygen-mediated
aberrant postnatal lung growth by growth factors.
Tanswell K. Canadian Institutes of Health
Research ($799,686 2005-2010)
Thyroid hormone insufficiencies and visual
perception deficits in preterm infants. Rovet J,
Asztalos E, Westall C, Heon E. March of Dimes
($253,083 2004-2007)
Rho-kinase inhibitor as therapy for chronic
neonatal pulmonary hypertension. Jankov RP,
McNamara PJ. Canadian Institutes of Health
Research Operating Grant ($323,592 2007-2010)
The developing lung: Cellular and molecular
physiology. Tanswell AK. Medical Research
Council/Canadian Institutes of Health Research
Group Grant ($1,285,443 2004-2009)
Role of peroxynitrite and macrophages in newborn
pulmonary vascular remodeling. Jankov RP.
Canadian Institutes of Health Research
($285,888 2005-2008)
The twin birth study: A multicentre randomised
controlled trial comparing planned caesarean
section with planned vaginal birth for twins at
32-38 weeks gestation. Barrett J, Hannah M,
Willan A, Ross S, Hutton E, Allen A, Joseph KS,
Armson A, Farrell S, Ohlsson A, Asztalos E,
Gafni A, Okun N, Leduc L. Canadian Institutes
of Health Research ($8,608,045 2003-2011)
Role of reactive oxygen/nitrogen species in
normal and aberrant postnatal lung growth.
Tanswell AK. Canadian Institutes of Health
Research ($708,400 2004-2009)
Steroids in immune mediated congenital complete
atrio-ventricular heart block (CAVB): Do they
affect brain development? Kelly EN, Sananes R,
Jaeggi ET. The Physicians’ Services Incorporated
Foundation ($42,000 2005-2006)
Strategic training initiative in research in
reproductive health sciences. Fraser WD, Campbell
M, Collet J, Davidge S, De Koninck M, Dodds L,
Dodin S, Fisher W, Gagnon R, Grant A, HatemAsmar M, Heaman M, Joseph K, Klein M, Labrecque
M, Lambert R, Lee S, Letourneau L, Leung P, Lye
S, McCoshen J, Moutquin J, Nisker J, Ohlsson A,
Pierson R, Sauve R, Smith G, Von Dadelszen P,
Walker M, Wood S. Canadian Institutes of Health
Research ($1,800,000 2002-2008)
Surveillance of kernicterus in Canada. Sgro M,
Campbell D, Shah V. Ontario Federation for
Cerebral Palsy ($25,100 2007-2008)
Survey of the attitudes and practices of
physicians and mothers regarding analgesia
during routine immunization in childhood. Taddio
A, Shah V, Ipp M, Sgro M. The Hospital for Sick
Children Paediatric Consultants Partnership’s
Grant ($5,050 2005-2006)
Survey of the attitudes and practices of
physicians and mothers regarding analgesia
during routine immunization in childhood. Taddio
A, Shah V, Ipp M, Sgro M. Canadian Pain Society
($1,000 2005-2006)
Survey of mode of delivery and maternal and
perinatal outcomes in Canada. Lee S, Armson A,
Allen V, Andruschuk J, Attenborough R, Bottomley
J, da Silva O, Frick C, Heaman M, Murphy P,
Pasquier J-C, Bujold E, Crane J, Dumont A,
Janssen P, Klein M, Liu S, Moutquin J-M, O’Brien
B, Ohlsson A, Platt R, Sauve R, von Dadelszen P,
Walker M. Canadian Institutes of Health
Research/World Health Organization ($250,000
2007-2009)
Using telemedicine strategies to prevent avoidable
blindness in retinopathy of prematurity. Kertes P,
Gibbins S, Asztalos E, Ells A, Maddelena P, Brent
M, Lam WC, Devenyi R, Jefferies A. EA Baker
Foundation ($40,000 2004-2006)
Using telemedicine strategies to prevent avoidable
blindness in retinopathy of prematurity: Reliability
and measures of pain. Kertes P, Gibbins S,
James AG. EA Baker Foundation of the National
Institute of the Blind ($40,000 2006-2008)
Ventilator-induced lung injury: Linking gene
expression, physiology and outcome. Kavanagh B,
Post M, Belik J. Canadian Institutes of
Health Research Operating Grant ($102,530
2003-2006)
Vasopressin in paediatric shock. Choong K,
Bohn D, Joffe A, Menum K, McNamara P, Litalien
C. Canadian Intensive Care Foundation ($20,000
2005-2006)
Vasopressin in paediatric shock. Choong K,
Bohn D, Joffe A, Menum K, McNamara P, Litalien
C. Laerdal Society ($12,730 2005-2006)
Vasopressin in paediatric shock. Choong K,
Bohn D, Joffe A, Menum K, McNamara P, Litalien
C. Canadian Institutes of Health Research
($136,792 2006-2007)
Vasopressin in paediatric shock. Choong K,
Bohn D, Joffe A, Menum K, McNamara P, Litalien
C. Heart and Stroke Foundation of Canada
($61,623 2006-2007)
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
73
Nephrology
DIVISIONAL OVERVIEW
The Nephrology Division in the past year has been very ably
led by Drs. Rosenblum and Langlois, while Dr. Geary was on
sabbatical leave. The leadership change has not resulted in
any change in the divisional activity, and clinical care and basic
research continue as beacons of our success. There is also
a commitment to increase clinical research productivity with
specific focus on Nephrotic Syndrome in Children, Prevention
of the Complications of Chronic Kidney Disease in Children,
and Management of Congenital Renal Malformations.
The training program was superbly led by Dr. Harvey, and
culminated in successful accreditation for another seven years.
Dr. Lisa Robinson was instrumental in development of the “Kids
Science” program designed to provide at-risk youth in Ontario with
exposure to careers in science and technology. The program is
funded by YSTOP (Youth Science and Technology Outreach Program)
through the Ministry of Research and Innovation, Government
of Ontario, with a grant for $150,000 over 3 years (2006-2009).
One of the components of the program was a two day science
symposium (Science Extravaganza) which included state-of-the-art
lectures, a luncheon hosted by various scientific and health-care
staff, a speech by the Premier of Ontario, and an evening banquet.
A 10-year review of the division was laudatory, and Dr. Geary was
reappointed as Division Chief for another five-year term.
HONOURS AND AWARDS
Licht C: Associate Scientist, Cell Biology Program,
Research Institute, The Hospital for Sick Children.
The Interface of the Complement and the
Coagulation System in Patients with aHUS, 2006.
Rosenblum ND: Canada Research Chair in
Developmental Nephrology (Tier 1), Canadian
Institutes of Health Research, 2005-2012.
Rosenblum ND: Outstanding Science Award,
American Pediatric Society, 2006.
PUBLICATIONS
Dr. Denis Geary
Alexander RT, Langlois V, Tellier R, Robinson L,
Hebert D: The prevalence of BK viremia and
urinary viral shedding in a pediatric renal
transplant population: A single-center retrospective
analysis. Pediatric Transplanation 2006: 10:
pp 586-592.
Cook A, Khoury A, Kader K, Hebert D, Navarro O,
Pippi-Salle J, Farhat W: Does peak systolic velocity
correlate with renal artery stenosis in a pediatric
renal transplant population? Pediatric
Transplantation 2006: 10: pp 608-612.
Fluss JE, Deveber G, Geary DF: Cerebral
sinovenous thrombosis and idiopathic nephrotic
syndrome in childhood: Report of four new
cases and review of the literature. European
Journal of Pediatrics 2006: 165: pp 709-716.
de Mezerville MH, Tellier R, Richardson S, Hebert
D, Doyle J, Allen U: Adenoviral infections in
pediatric transplant recipients: A hospital-based
study. Pediatric Infectious Diseases 2006: 9:
pp 815-818.
Gill PS, Rosenblum ND: Control of murine kidney
development by Sonic Hedgehog and its GLI
effectors. Cell Cycle 2006: 5: pp 1426-1430.
Durkan A, Alexander RT, Liu GY, Rui M, Fernia G,
Robinson L: Expression and targeting of CX3CL1
(Fractalkine) in renal tubular epithelial cells.
Journal of the American Society of Nephrology
2007: 18: pp 74-83.
Durkan A, Keating L, Vigneux A, Geary D: The
use of darbepoetin in infants with chronic renal
impairment. Pediatr Nephrol. 2006: 21:
pp 694-697.
Division Head
Dr. Denis F. Geary
Dr. Lisa A. Robinson
Honorary
Dr. Norman D. Rosenblum Dr. Gerald S. Arbus
Full-Time
Dr. Elizabeth A. Harvey
Dr. Diane HГ©bert
Dr. Valerie Langlois
Dr. Christoph Licht
Dr. Tino D. Piscione
Part-Time
Dr. Marion Cummings
Dr. Rachel Pearl
Adjunct
Dr. Leo Levin
Dr. Meeta Mallik
Dr. Rola Saqan
Dr. Aoife Waters
Clinical Fellows
Dr. Mohamed Al Maghrabi Research Fellow
Dr. Thoraya Al Maslamani Dr. Todd Alexander
Dr. Indra Ganesan
Subspecialty Residents
Dr. Rajesh Krishnan
Dr. Dana Al-Nabhani
Hothi DK, St George-Hyslop C, Geary D, Bohn D,
Harvey E: Continuous renal replacement therapy
(CRRT) in children using the AQUARIUS.
Nephrology Dialysis Transplantation 2006: 21:
pp 2296-2300.
Hothi KD, Geary DF, Fisher L, Chan CT: Short-term
effects of nocturnal haemodialysis on carnitine
metabolism. Nephrology Dialysis Transplantation
2006: 21: pp 2637-2641.
Dr. Susan Koshy
Dr. Katherine Martin
Dr. Lindsay Teskey
Clinical Research
Associates
Michelle Frieling
Laura Keating
Administrative Staff
Dana Debernyj
Juliet Rodrigo
Bernard Singh
Marisa Tuzi
Humar A, Hebert D, Davies HD, Humar A,
Stephens D, O’Doherty B, Allen U: A randomized
trial of ganciclovir versus ganciclovir plus immune
globulin for prophylaxis against Epstein-Barr
virus related posttransplant lymphoproliferative
disorder. Transplantation 2006: 81: pp 856-861.
Jozsi M, Heinen S, Hartmann A, Ostrowicz C,
Halbich S, Richter H, Kunert A, Licht C, Saunders
RE, Perkins SJ, Zipfel P, Skerka C: C-terminal
mutations of the immune regulatory factor H as
described in patients with atypical hemolytic
uremic syndrome. Journal of the American Society
of Nephrology 2006: 17: pp 170-177.
Licht C, Heinen S, Jozsi M, Loschmann I,
Saunders RE, Perkins SJ, Waldherr R, Skerka C,
Kirschfink M, Hoppe B, Zipfel PF: Deletion of a
single amin acid (K224) in the regulatory domain
of the immune inhibitor factor H reveals a novel
pathomechanism for membranoproliferative
glomerulonephritis type II. Kidney International
2006: 70: pp 42-50.
McKenna AM, Keating LE, Vigneux A, Stevens S,
Williams A, Geary DF: Quality of life in children
with chronic kidney disease-patient and caregiver
assessments. Nephrology Dialysis Transplantation
2006: 21: pp 1899-1905.
Sidhu G, Beyene J, Rosenblum ND: Outcome of
isolated antenatal hydronephrosis: A systematic
review and meta-analysis. Pediatric Nephrology
2006: 21: pp 218-224.
Sweeney C, Geary DF, Hebert D, Robinson L,
Langlois V: Outpatient pediatric renal transplant
biopsy – Is it safe? Pediatric Transplantation
2006: 10: pp 159-161.
Turner D, Schreiber R, Grant D, Hebert D,
Sherman PM: Hemolytic uremic syndrome after
pediatric liver transplantation. Journal of Pediatric
Gastroenterology and Nutrition 2006: 43:
pp 109-112.
76
DEPARTMENT OF PAEDIATRICS
von Schnakenburg C, Feneberg R, Plank C,
Zimmering M, Arbeiter K, Bald M, Fehrenbach H,
Griebel M, Licht C, Konrad M, Timmermann K,
Kemper MJ for the APN (Arbeitsgemeinschaft
Paediatrische Nephrologie): Percutaneous
endoscopic (PEG) or open gastrostomy in 30
children on peritoneal dialysis. Peritoneal Dialysis
International 2006: 26: pp 69-77.
Wong H, Laberge R, Harvey E, Filler G:
Preventing sensitization with mycophenolate
mofetil in a pediatric kidney recipient. Pediatric
Transplantation 2006: 10: pp 367-370.
Wong H, Hadi M, Geary D, Khoury T, Rubin B:
Management of severe hypertension in a child
with tuberous sclerosis-related major vascular
abnormalities. J Hypertens 2006 Mar: 24(3):
pp 597-599.
Zipfel PF, Misselwitz J, Licht C, Skerka C: The role
of defective complement control in hemolytic
uremicsyndrome. Seminars in Thrombosis and
Hemostasis 2006: 32: pp 146-154.
FUNDING
Canada Research Chair in Developmental
Nephrology, Tier I. Rosenblum ND. Canada
Research Chairs Program ($200,000/year
2005-2012)
Canadian Child Health Clinician-Scientist Program
Rosenblum ND. Canadian Institutes of Health
Research ($300,000/year 2002-2008)
Canadian Paediatric Clinician Scientist
Program. Rosenblum ND. SickKids Foundation
($300,000/year 2002-2008)
Canadian Paediatric Clinician Scientist Program.
Rosenblum ND. B.C. Research Institute for
Children’s and Women’s Health ($150,000/year
2002-2008)
Canadian Paediatric Clinician-Scientist Program.
Rosenblum ND. B.C. Children’s Hospital
Foundation ($150,000/year 2002-2008)
Cellular regulation of Fractalkine. Lisa Robinson:
The Heart and Stroke Foundation of Ontario,
Grant-in-Aid ($171,944 2005-2007)
Control of kidney morphogenesis by sonic
hedgehog and its signaling effectors. Rosenblum
ND. Canadian Institutes of Health Research
($134,419/year 2006-2009)
Evaluation of photograph database use in
children. Geary DF. Genzyme Inc. ($13,000
2006-2008)
Kids Science. Robinson L. Ministry of Research
and Innovation, Youth Science and Technology
Outreach Program ($150,000 2006-2009)
Molecular mechanisms that control branching
morphogenesis in the normal and dysplastic
kidney. Rosenblum ND. Canadian Institutes of
Health Research ($148,700/year 2003-2008)
Role of the Notch pathway in kidney development.
Piscione TD. SickKids Research Institute
($101,500 2006-2008)
Role of the Notch pathway in kidney development.
Piscione TD. Department of Paediatrics, The
Hospital for Sick Children ($37,500 July 2006)
Steroid-induced Osteoporosis in the Paediatric
Population – Canadian Incidence Study (The
STOPP Study). Ward L, Alos N, Atkinson SA, Barr
RD, Chanoine J-P, Clarson CL, Clifford TJ, Couch,
RM, Cummings EL, Feber J, Filler G, Gaboury I,
Glorieux FH, Grant RM, Halton JM, Hay JA, Huber
AM, Lang BA, Leblanc CM, Matzinger MAE, Moher
D, Rauch F, Rodd CJ, Stephure DK, Taback SP,
Webber CE, Hebert D. Canadian Institutes of
Health Research ($598,026 2003-2008)
The role of Notch1 in kidney development.
Piscione TD. The Kidney Foundation of Canada
($149,610 2004-2007)
The role of slit/robo signaling in renal
Inflammation. Robinson L. Canada Research
Chairs, Tier 2 ($500,000 2004-2009)
The role of slit/robo signaling pathways in
kidney inflammation. Robinson L. Early
Researcher Award, Government of Ontario
($100,000 2006-2008)
Control of branching morphogenesis in the normal
and dysplastic kidney. Rosenblum ND. Canadian
Institutes of Health Research ($147,000/year
2003-2008)
ANNUAL REPORT 2006-07
Dr. Christoph Licht
Hu MC, Mo R, Bhella S, Wilson CW, Chuang P-T,
Hui C-C, Rosenblum ND: GLI3-dependent
transcriptional repression of Gli1 and Gli2 and
kidney patterning genes disrupts renal
morphogenesis. Development 2006: 133:
pp 569-578.
Division Head
Dr. O. Carter Snead III
Full-Time
Dr. Rand Askalan
Dr. Brenda Banwell
Dr. Gabrielle deVeber
Dr. Elizabeth Donner
Dr. Cecil Hahn
Dr. Daune MacGregor
Dr. Berge Minassian
Dr. Teesta Soman
Dr. Ingrid Tein
Dr. Jiri Vajsar
Dr. Shelly Weiss
Part-Time
Dr. David Berbrayer
Dr. Joseph Bruni
Dr. Pamela Cooper
Dr. Jonathan Gladstone
Dr. Jeffrey Kobayashi
Dr. Betty Koo
Dr. Wayne Langburt
Dr. Shanna Lindsay
Dr. William Logan
Dr. John Lovering
Dr. Gilbert Miller
Dr. Peter Rumney
Honorary
Dr. Douglas McGreal
Dr. E. Gordon Murphy
Dr. Diann Superina-Bell
Scientific Staff
Dr. Miguel Cortez
Dr. Maureen Lovett
Dr. James MacFarlane
Dr. Hiroshi Otsubo
Dr. Elizabeth Pang
Dr. Mary Lou Smith
Dr. Margot Taylor
Dr. Jose Luis
Perez Velazquez
Neurology
DIVISIONAL OVERVIEW
The major foci of the clinical activities of the Division of
Neurology are epilepsy, stroke, headache, neurometabolic
disease, neuromuscular disease, sleep disorders, movement
disorders, multiple sclerosis, functional neuroimaging and
neurointensive care.
Dr. Rand Askalan and team members
The Division of Neurology has a Royal College accredited training
program in Child Neurology as well as postdoctoral training
programs in epilepsy and stroke. In addition, there are a number
of graduate students and postdoctoral fellows in clinical
neurophysiology and molecular and cellular neurobiology. The
research foci of the Division of Neurology is epilepsy (both
clinical and basic research), magnetoencephalography, stroke,
dyslexia, burden of disease and quality of life, muscular
dystrophy, multiple sclerosis, fatty acid oxidation disorders, and
molecular and cellular neurobiology.
Trainees
Dr. Kristen Wentlandt
Dr. Reem Al-Khater
Dr. Naila Makhani
Dr. Jorina Elbers
Dr. Emily Tam
Dr. David Callen
Dr. Rand Askalan
Departmental Fellows
Epilepsy Fellows
Dr. Juan Pablo Appendino Dr. Derrick Chan
Dr. Cristina Go
Dr. Klaus Werner
Dr. Ismail Mohamed
Stroke Fellows
Dr. Erick Sell
Dr. Adam Kirton
Dr. Mahendranath
Moharir
Dr. M. Tan
Research Fellows
Dr. Katsumi Imai
Dr. Ayataka Fujimoto
Self-Funded Fellow
Dr. Terrence Thomas
Administrative Staff
Erin Crawford
Maureen Hodge
Fatima Ledo
Michelle Lo
Marilyn McLaughlin
Susy O’Neill
Wendy Ricketts
Laura Toth
Barbara Zimnowodzki
Appendino JP: William J. Logan Award for
Excellence in Clinical Teaching, Division of
Neurology, The Hospital for Sick Children, 2007.
Banwell B: Canada’s Top 40 Under 40 Recipient,
2006.
Banwell B: American Academy of Neurology
Leadership Development Program (Selected),
2006.
Banwell B: Women Against Multiple Sclerosis
Award – Multiple Sclerosis Society of Canada,
2007.
Cortez M: William A. Hawke Award for Excellence
in Clinical Teaching, Division of Neurology, The
Hospital for Sick Children, 2007.
deVeber G: Canadian Paediatric Society “Geoffrey
C. Robinson Award”, June 2007.
Kirton A: 2007 Prichard Day Prize Winner, “Motor
Outcome and Reorganization Prediction in
Childhood Stroke Using Diffusion MR and TMS”.
MacGregor DL: 7 Year Volunteer Long Service
Award, Bloorview Children’s Hospital Foundation,
2007.
Minassian B: Canada Research Chair in Paediatric
Neurogenetics, 2006.
Minassian B: Dreifuss-Penry Epilepsy Award,
American Academy of Neurology, 2007.
Tein I: Elected Member, International Child
Neurology Association Executive Board.
Tein I: Appointed Chair, Scientific Program
Committee, XIth International Child Neurology
Congress, Cairo, Egypt, 2010.
PUBLICATIONS
Ackerley CA, Minassian BA: Animal models of
Lafora Disease. Microscopy and Microanalysis
2006: 12: pp 12-13.
Akiyama T, Otsubo H, Ochi A, Galicia EZ,
Weiss SK, Donner EJ, Rutka JT, Snead OC III:
Topographic movie of ictal high-frequency
oscillations on the brain surface using subdural
EEG in neocortical epilepsy. Epilepsia 2006: 47:
pp 1953-1957.
Andrade DM, Scherer SW, Minassian BA: Protein
therapy for Unverricht-Lundborg disease using
cystatin B transduction by TAT-PTD. Is it that
simple? Epilepsy Research 2006: 72: pp 75-79.
80
DEPARTMENT OF PAEDIATRICS
Askalan R, deVeber G, Ho M, Ma J, Hawkins C:
Astrocytic-inducible nitric oxide synthase in the
ischemic developing human brain. Pediatric
Research 2006: 60: pp 439-445.
Bercovici E, Cortez MA, Snead OC III: 5-HT2
modulation of AY-9944 induced atypical absence
seizures. Neuroscience Letters 2007: 418:
pp 13-17.
Aviv RI, Benseler SM, deVeber G, Silverman ED,
Tyrrell PN, Tsang LM. Armstrong D: Angiography of
primary central nervous system angiitis of childhood: Conventional angiography versus magnetic
resonance angiography at presentation. American
Journal of Neuroradiology 2007: 28: pp 9-15.
Braun KP, Kappelle LJ, Kirkham FJ, deVeber G:
Diagnostic pitfalls in paediatric ischaemic stroke.
Developmental Medicine and Child Neurology
2006: 48: pp 985-990.
Banwell B, Shroff M, Ness JM, Jeffrey D, Schwid
S, Weinstock-Guttman B: RI features of pediatric
multiple sclerosis. Neurology 2007: 68:
pp S46-S53.
Barcelo-Coblijn G, Murphy EJ Mills K, Winchester
B, Jakobs C, Snead OC, Gibson KM: Lipid
abnormalities in succinate semialdehyde
dehydrogenase (Aldh5a1(-/-)) dehydrogenase
mouse brain provide additional evidence
for myelin alterations. Biochimica et Biophysica
ACTA/General Subjects (Amsterdam) 2007:
1772: pp: 556-562.
Bayless SJ, Gaetz W, Cheyne DO, Taylor MJ:
Spatial and temporal localization of feedback
processing using MEG and event-related synthetic
aperture magnetometry. Neuroscience Letters
2006: 410: pp 31-36.
Belman AL, Chitnis T, Renoux C, Waubant E,
Banwell B: Challenges in the classification of
pediatric multiple sclerosis and future directions.
Neurology 2007: 68: pp S70-S74.
Benifla M, Otsubo H, Ochi A, Snead OC III, Rutka
JT. Multiple subpial transactions in pediatric
epilepsy: Indications and outcomes. Child’s
Nervous System 2006: 22: pp 992-998.
Benifla M, Otsubo H, Ochi A, Weiss S, Donner E,
Shroff M, Chuang S, Hawkins C, Drake JM, Elliott
I, Smith ML, Snead OC III, Rutka JT: Temporal lobe
surgery for intractable epilepsy in children: An
analysis of outcomes in 126 children.
Neurosurgery 2006: 59: pp 1203-1214.
Benifla M, Rutka JT, Logan WJ, Donner EJ: Vagal
nerve stimulation for refractory epilepsy in
children: Indications and experience at The
Hospital for Sick Children. Child’s Nervous System
2006: 22: pp 1018-1026.
Bentin S, Taylor MJ, Rousselet GA, Itier RJ,
Caldara R, Schyns PG, Jacques C, Rossion: Much
ado about nothing: Controlling interstimulus
perceptual variance does not abolish N170 face
sensitivity. Nature Neuroscience 2007: 10:
pp 801-802.
ANNUAL REPORT 2006-07
Braun KP, Rafay MF, Uiterwaal CS, Pontigon AM,
deVeber G: Mode of onset predicts etiological
diagnosis of arterial ischemic stroke in children.
Stroke 2007: 38: pp 298-302.
Elbers JM, Bitnun A, Richardson SE, Ford-Jones
EL, Tellier R, Wald RM, Petric M, Kolski H, Heurter
H, MacGregor D: A 12-year prospective study of
childhood herpes simplex encephalitis: Is there a
broader spectrum of disease? Pediatrics 2007:
119: pp 399-407.
Feasby T, Banwell B, Benstead T, Bril V, Brouwers
M, Freedman M: Guidelines on the use of
intravenous immune globulin for neurologic
conditions. Transfusion Medicine Reviews 2007:
21: pp S57-S107.
Fluss J, Geary D, deVeber G: Cerebral sinovenous
thrombosis and idiopathic nephritic syndrome in
childhood: Report of 4 new cases and review of
literature. European Journal of Pediatrics 2006:
165: pp 709-716.
Gallagher S, Weiss SK, Oram Cardy J, Humphries
T, Harman KE, Menascu S: Efficacy of very high
dose steroid treatment in a case of LandauKleffner syndrome. Developmental Medicine and
Child Neurology 2006: 48: pp 766-769.
Georgiou D-M, Nicholaou P, Chitayat D, Koutsou P,
Babul-Hirji R, Vajsar J, Murphy J, Christodoulou K:
A novel GDAP1 mutation 439delA is associated
with autosomal recessive CMT disease. Canadian
Journal of Neurological Sciences 2006: 33:
pp 311-316.
Gladstone JP: An approach to the patient with
painful ophthalmoplegia – focus on Tolosa-Hunt
syndrome. Current Pain and Headache Reports
2007: 11: pp 317-325.
Grodin R, Chuang S, Otsubo H, Holowka S, Snead
OC III, Raybaud C, Rutka JT: The role of
magnetoencephalography in pediatric epilepsy
surgery. Child’s Nervous System 2006: 22:
pp 779-785.
Hahn JS, Pohl D, Rensel M, Rao S, Banwell B:
Differential diagnosis and evaluation in pediatric
multiple sclerosis. Neurology 2007: 68:
pp S13-S22.
Dr. Cecil Hahn with Epilepsy fellows and staff
HONOURS AND AWARDS
Harvey CG, Menon SD, Stachowiak B, Noor A,
Proctor A, Mensah AK, Mnatzakanian GN, Alfred
SE, Guo R, Scherer SW, Kennedy JL, Roberts W,
Srivastava AK, Minassian BA, Vincent JB:
Sequence variants within exon 1 of MECP2
occur in females with mental retardation.
American Journal of Medical Genetics Part B:
Neuropsychiatric Genetics 2007: 144:
pp 355-360.
Hashizume A, Iida K, Shirozu H, Hanaya R,
Kiura Y, Kurisu K, Otsubo H: Gradient magneticfield topography for dynamic changes of epileptic
discharges. Brain Research 2007: 1144:
pp 175-179.
Hune SY, deVeber GA, MacGregor DL, Dirks PB,
Yu HW, Soman TB, Allen A, Golomb MR: Nursing
issues in caring for children with moyamoya
vasculopathy and their families. Journal of
Neuroscience Nursing 2007: 39: pp 33-39.
Itier RJ, Herdman AT, George N, Cheyne DO, Taylor
MJ: Inversion and contrast-reversal effects on face
encoding and recognition assessed by MEG. Brain
Research 2006: 1115: pp 108-120.
Kadis D, Iida K, Kerr EN, Logan WJ, McAndrews
MP, Ochi A, Otsubo H, Rutka J, Snead OC III, Weiss
SK, Smith ML: Intrahemispheric reorganization of
language in children with medically intractable
epilepsy of the left hemisphere. Journal of the
International Neuropsychological Society 2007: 13:
pp 505-516.
Kirton A, deVeber G: Ischemic stroke complicating
pediatric cardiovascular disease. Nature Clinical
Practice. Cardiovascular Medicine 2007: 4:
pp 163-166.
Kirton A, deVeber G: Perinatal ischemic stroke.
Stroke Review 2006: 10: pp 38-47.
Kirton A, Hill MD, deVeber G: Arterial ischemic
strokes in neonates and children: Review and
current issues. Current Pediatric Reviews 2006:
2: pp 301-314.
Kirton A, Schechter T, Brandao L, Chan A,
Williams S, MacGregor D, Pontigon A, deVeber G:
Hemorrhagic transformation of arterial ischemic
strokes in children. Stroke 2007: 38: pp 581.
82
DEPARTMENT OF PAEDIATRICS
Kirton A, Shroff M, Visvanathan T, deVeber G:
Quantified corticospinal tract diffusion restriction
predicts neonatal stroke outcome. Stroke 2007:
38: pp 974-980.
Kossoff EH, Pyzik PL, Rubenstein JE, Bergqvist
AGC, Buchhalter JR, Donner EJ, Nordi Jr DR,
Wheless JW: Combined ketogenic diet and vagus
nerve stimulation: Rational polytherapy? Epilepsia
2007: 48: pp 77-81.
Krupp LB, Banwell B, Tenembaum S: Consensus
definitions proposed for pediatric multiple
sclerosis and related disorders. Neurology 2007:
68: pp S7-S12.
Kuban KC, O’Shea M, Allred E, Leviton A, Gilmore
H, DuPlessis A, Krishnamoorthy K, Hahn C, Soul J,
O’Connor SE, Miller K, Church PT, Keller C, Bream
R, Adair R, Miller A, Romano E, Bassan H,
Kerkering K, Engelke S, Marshall D, Milowic K,
Wereszczak J, Hubbard C, Washburn L, Dillard R,
Heller C, Burdo-Hartman W, Fagerman L, Sutton D,
Karna P, Olomu N, Caldarelli L, Oca M, Lohr K,
Scheiner A: Video and CD-ROM as a training tool
for performing neurologic examinations of 1-yearold children in a multicenter epidemiologic study.
Journal of Child Neurology 2006: 20: pp 829-831.
Lamhonwah AM, Hawkins C, Mai L, Tein I:
Expression patterns of organic cation/carnitine
transporter family in adult murine brain. Brain
and Development. June 16, 2007 [Epub ahead
of print].
Lamhonwah AM, Tein I. Novel localization of
OCTN1, an organic cation/carnitine transporter,
to mammalian mitochondria. Biochemical
& Biophysical Research Communications 2006:
345: pp 1315-1325.
Latinus M, Taylor MJ: Face processing stages:
Impact of difficulty and the separation of effects.
Brain Research 2006: 1123: pp 179-187.
Leshchenko Y, Likhodii S, Yue W, Burnham WM,
Perez Velazquez JL: Carbenoxolone does not cross
the blood brain barrier: An HPLC study. BMC
Neuroscience 2006: 7: p 3.
Loh A, Soman T, Brian J, Bryson SE, Roberts W,
Szatmari P, Smith IM, Zwaigenbaum L: Stereotyped
motor behaviours associated with autism in highrisk infants: A pilot videotape analysis of a sibling
sample. Journal of Autism and Developmental
Disorders 2007: 37: pp 25-36.
ANNUAL REPORT 2006-07
Lohi H, Turnbull J, Zhao XC, Pullenayegum S,
Ianzano L, Yahyaoui M, Mikati MA, Franceschetti
S, Zara F, Minassian BA: Genetic diagnosis in
Lafora Disease: Genotype-phenotype correlations
and diagnostic pitfalls. Neurology 2007: 68:
pp 996-1001.
MacAllister WS, Boyd JR, Holland NJ, Milazzo MS,
Krupp LB for the International Pediatric MS
Study Group: The psychosocial consequences
of pediatric multiple sclerosis. Neurology 2007:
68: pp S66-S69.
MacGregor D, Tallett S, MacMillan S, Gerber R,
O’Brodovich H: Clinical and education workload
measurements using personal digital assistant
based software. Pediatrics 2006: 118:
pp e985-991.
Maegawa G, Stockley T, Tropak M, Banwell B,
Blaser S, Kok K, Giugliani R, Mahuran D, Clarke J:
The natural history of juvenile or subacute GM2
gangliosidosis: 21 new cases and literature review
of 134 previously reported. Pediatrics 2007:
118: pp 1550-1562.
Mohamed I, Otsubo H, Pang E, Chuang SH, Rutka
JT, Dirks P, Weiss SK, Snead OC III: Magnetoencephalographic spike sources associated with
auditory auras in pediatric localization-related
epilepsy. Journal of Neurology, Neurosurgery and
Psychiatry 2006: 77: pp 1256-1261.
Mohamed IS, Otsubo H, Donner EJ, Ochi A,
Sharma R, Drake J, Rutka JT, Chuang SH, Holowka
S, Snead III OC: Magnetoencephalography for
surgical treatment of refractory status epilepticus.
Acta Neurologica Scandivavica 2007: 115:
pp 29-36.
Mohamed IS, Otsubo H, Shroff M, Donner E,
Drake J, Snead III OC: Magnetoencephalography
and diffusion tensor imaging in gelastic seizures
secondary to a cingulate gyrus lesion. Clinical
Neurology and Neurosurgery 2007: 109:
pp 182-187.
Ness JM, Chabas D, Sadovnick AD, Pohl D,
Banwell B, Weinstock-Guttman B: Clinical features
of children and adolescents with multiple
sclerosis. Neurology 2007: 68: pp S37-S45.
O’Brodovich H, Beyene J, Tallett S, MacGregor D,
Rosenblum ND: Performance of a career
development and compensation program at an
academic health science centre. Pediatrics 2007:
119: pp e791-e797.
Ochi A, Otsubo H, Donner E, Elliott I, Iwata R,
Funaki T, Akizuki Y, Akiyama T, Rutka JT, Snead
OC: Dynamic changes of ictal high-frequency
oscillations in neocortical epilepsy: Using multiple
band frequency analysis. Epilepsia 2007: 48:
pp 286-296.
O’Connor K, McLaughlin KA, De Jager PL, Chitnis
T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or
A, Banwell B, Fukaura H, Tenembaum S, Wong SJ,
Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K,
Pohl D, Dale RC, Freedman M, Steinman L, Buckle
GJ, Kuchroo VK, Hafler DA, Wucherpfennig KW:
Self-assembling antigen tetramers permit
discrimination of autoantibodies to folded and
denatured self-antigens in demyelinating diseases.
Nature Medicine 2007: 13: pp 211-217.
Oishi M, Otsubo H, Iida K, Suyama Y, Ochi A,
Weiss SK, Xiang J, Gaetz W, Cheyne D, Chuang
SH, Rutka JT, Snead OC: Presurgical stimulation of
intracerebral epileptiform discharges. Synthetic
aperture magetometry virtual sensor analysis of
interictal magnetoencephalography data. Journal
of Neurosurgery 2006: 105: pp 41-49.
Payne ET, Rutka JT, Ho TK, Halliday WC, Banwell
B: Treatment leading to dramatic recovery in acute
hemorrhagic leukoencephalitis. Journal of Child
Neurology 2007: 22: pp 109-113.
Perez Velazquez, JL: Brain research: a perspective
from the coupled oscillators field
NeuroQuantology 2006: 4: pp 155-165.
Perez Velazquez JL: Functional contribution of
specific brain areas to absence seizures: Role of
thalamic gap-junctional coupling. European
Journal of Neuroscience 2006: 23: pp 489-496.
Perez Velazquez JL, Garcia Dominguez L,
Wennberg R: Complex phase synchronization in
epileptic seizures: Evidence for a devil’s staircase.
Physical Review E: Statistical, Non-linear & Soft
Matter Physics 2007: 75: p 011922 [Epub].
Perez Velazquez JL, Kokarovtseva L, Sarbaziha R,
Jeyapalan Z, Leschenko Y: Role of gap junctional
coupling in astrocytic networks in the determination of global ischaemia-induced oxidative stress
and hippocampal damage European Journal of
Neuroscience 2006: 23: pp 1-10.
Petel-Galil Y, Benteer B, Galil YP, Zeev BB,
Greenbaum I, Vecsler M, Goldman B, Lohi H,
Minassian BA, Gak E: Comprehensive diagnosis
of Rett’s syndrome relying on genetic, epigenetic
and expression evidence of deficiency of the
methyl-CpG-binding protein 2 gene: Study of
a cohort of Israeli patients. Journal of Medical
Genetics 2006: 43: p e56.
Picton, TW, Taylor MJ: Electrophysiological
evaluation of human brain development.
Developmental Neuropsychology 2007: 31:
pp 251-280.
Pohl D, Waubant B, Chabas D, Chitnis T,
Weinstock-Guttman B, Tenembaum S: Treatment
of pediatric multiple sclerosis and variants.
Neurology 2007: 68: pp S54-S65.
RamachandranNair R, Otsubo H, Shroff MM, Ochi
A, Weiss SK, Rutka JT, Snead OC III: MEG predicts
outcome following surgery for intractable epilepsy
in children with normal or non-focal MRI findings.
Epilepsia 2007: 48: pp 149-157.
Rodan LH, Aviv RI, Sahlas DJ, Murray BJ,
Gladstone JP, Gladstone DJ. Seizures during
stroke thrombolysis heralding dramatic neurologic
recovery. Neurology 2006: 67: pp 2048-2049.
Rubenstein S, Malone MA, Roberts W, Logan WJ:
Placebo-controlled study examining effects
of selegiline in children with attention deficit
hyperactivity disorder. Journal of Child and
Adolescent Psychopharmacology 2006: 16:
pp 404-415.
Saengpattrachai M, Ray PN, Hawkins CE, Berzen
A, Banwell B: Grandpa and I have dystrophinopathy?: Approach to asymptomatic hyperCKemia.
Pediatric Neurology 2006: 35: pp 145-149.
Saengpattrachai M, Sharma R, Hunjan A, Shroff
M, Ochi A, Otsubo H, Cortez MA, Snead OC:
Nonconvulsive seizures in the pediatric intensive
care unit. Etiology, EEG, and brain imaging
findings. Epilepsia 2006: 47: pp 1510-1518.
Salter R, King SM, Smith ML, Bitnun A, Brophy J,
Fernandes-Penney A, Lefebvre A, Louch D,
MacDougall G, Moore W, Read SE: Disclosing HIV
diagnosis to infected children: A health care
team’s approach. Vulnerable Children and Youth
Studies Journal 2007: 2: pp 12-16.
Shemie SD, Doig C, Dickens B, Byrne P, Wheelock
B, Rocker G, Baker A, Seland TP, Guest C, Cass D,
Jefferson R, Young K, Teitelbaum J on behalf of
the Pediatric Reference Group and the Neonatal
Reference Group (Hahn C, Member): Brain injury
to neurological determination of death: Canadian
Council for Donation and Transplantation Forum
Recommendations. Canadian Medical Association
Journal 2006: 14: pp S1-S13.
Smirnov D, Dikanev T, Wennberg R, Perez
Velazquez JL, Bezruchko B: Dynamical
nonstationarity in electroencephalograms for
temporal lobe epilepsy. Biomedical Technologies
and Radio Electronics, 2006: 12: pp 26-32.
Smith ML, Elliott IM, Lach, LM. Memory outcome
after pediatric epilepsy surgery: Objective and
subjective perspectives. Child Neuropsychology
2006: 12: pp 151-160.
Stewart L, Persinger MA, Cortez MA, Snead OC III:
Chronobiometry of behavioural activity in the
Ts65Dn model of Down syndrome. Behaviour
Genetics 2006: 37: pp 388-398.
Stewart LS, Shukla R, Serbanescu I, Persad V,
Mistry N, Bercovici E, Cortez MA, Snead OC: Daily
rhythms of seizure activity and behavior in a
model of atypical absence epilepsy. Epilepsy and
Behavior 2006: 9: pp 564-572.
Sy K, Mahant S, Taback N, Vajsar J, Chait PG,
Friedman JN: Enterostomy tube placement in
children with spinal muscular atrophy type 1.
Journal of Pediatrics 2006: 149: pp 837-839.
Tenembaum S, Chitnis T, Ness J, Hahn JS, Banwell
B: Acute disseminated encephalomyelitis.
Neurology 2007: 68: pp S23-S36.
Tetreault M, Duquette A, Thiffault I, Bherer C, Jarry
J, Loisel L, Banwell, B, D’Anjou G, Mathieu J,
Robitaille Y, Karpati G, Vanasse M, Brais B: A new
form of congenital muscular dystrophy with joint
hyperlaxity maps to 3p23-21. Brain 2006: 129:
pp 2077-2084.
BOOKS AND BOOK CHAPTERS
FUNDING
Gladstone JP, Brandes JL: Diagnosis and
classification of primary headache disorders. In:
Standards of Care for Headache Diagnosis and
Treatment (Freitag FG, Cady RK, eds). National
Headache Foundation.
Atypical absence epilepsy: GABA B receptormediated mechanisms. Snead OC III, Francis J,
Cortez MA. Canadian Institutes of Health
Research ($315,376 2000-2008)
Vajsar J, Schachter H: Walker-Warburg syndrome.
Orphanet Journal of Rare Disorders 2006: 1: p 29.
Hahn CD, du Plessis AJ: Neurologic disorders
associated with cardiac disease. In: Pediatric
Neurology: Principles & Practice 4th Edition
(Ferreiro DM, Swaiman KF, Ashwal S, eds).
Mosby, St. Louis, 2006.
Vajsar J: MRI findings in congenital muscular
dystrophies associated with brain abnormalities.
Future Neurology 2006: 1: pp 765-773.
Wang W, Lohi H, Skurat AV, Depaoli-Roach AA,
Minassian BA, Roach PJ: Glycogen metabolism in
tissues from a mouse model of Lafora disease.
Archives of Biochemistry and Biophysics 2007:
457: pp 264-269.
Wieser HG, Jones-Gotman M, Smith ML, Zumsteg
D, Mueller S, Buck A, Regard M, Yonekawa Y,
Valavanis A. Selective temporal lobe amobarbital
memory test. Epileptogologia 2007: 15:
pp 85-106.
Wilejto M, Buncic JR, Kennedy J, Banwell B: The
clinical features, MRI findings, and outcome of
optic neuritis in children. Neurology 2006: 67:
pp 258-262.
Wise JC, Sevcik RA, Morris RD, Lovett MW, Wolf
M: The growth of phonological awareness by
children with reading disabilities: A result of
semantic knowledge or knowledge of graphemephoneme correspondences? Scientific Studies of
Reading 2007: 11: pp 151-164.
Wu Y, Chan K, Eubanks J, Wong CG, Cortez MA,
Shen L, Liu CC, Perez Velazquez JL, Wang YT, Jia Z,
Snead OC: Transgenic mice over-expressing
GABABR1a receptors acquire an atypical absence
epilepsy-like phenotype. Neurobiology of Disease
2007: 26: pp 439-451.
MacGregor DL, Kulkarni A, Dirks P, Rumney P,
(eds): Head Injury in Children and Adolescents.
International Child Neurology Review Series.
MacKeith Press, London, UK, 2007.
Menascu S, MacGregor DL: Mild closed head
injury. In: Head Injury in Children and Adolescents;
International Child Neurology Review Series
(MacGregor DL, Kulkarni A, Dirks P, Rumney P,
eds). MacKeith Press, London, UK, 2007.
Perez-Velazquez J-L, Bertram EH, Snead OC:
Idiopathic generalized epilepsy. In: Neurobiology
of Disease (Gilman S, ed). Elsevier, New York,
2006.
Rumney P: Comprehensive Multidisciplinary
Rehabilitation. In: Head Injury in Children and
Adolescents; International Child Neurology Review
Series (MacGregor DL, Kulkarni A, Dirks P, Rumney
P, eds). MacKeith Press, London, UK, 2007.
Rumney P: Overview of Outcomes. In: Head Injury
in Children and Adolescents; International Child
Neurology Review Series (MacGregor DL, Kulkarni
A, Dirks P, Rumney P, eds). MacKeith Press,
London, UK, 2007.
Tein I: Primary carnitine transporter defect. In:
Neurobase, 13th Edition (Gilman N, Goldstein
GW, Waxman SG, eds). Arbor Publishing Corp,
La Jolla, CA, 2007.
Vajsar J. Congenital muscular dystrophies with
structural brain abnormalities: The role of brain
MRI. In: Medimond International Proceedings
of the 10th International Child Neurology
Congress (International Child Neurology Congress,
ed). Medimond Proceedings, Montreal, 2006.
Weiss SK: Better Sleep for Your Baby & Child:
A Parent’s Step-by-Step Guide to Healthy Sleep
Habits (Bob Hilderley, ed). Robert Rose Inc.,
Toronto, 2006.
Weiss S, RamachandranNair R, MacGregor DL:
Sleep and metabolism. In: Head Injury in Children
and Adolescents; International Child Neurology
Review Series (MacGregor DL, Kulkarni A,
Dirks P, Rumney P, eds). MacKeith Press, London,
UK, 2007.
Atypical absence epilepsy: GABABR-mediated
mechanisms. Snead OC III. Canadian Institutes
of Health Research ($705,000 2003-2008)
Carnitine-responsive cardiomyopathy & the
different-affinity carnitine transporters. Tein I.
The Heart and Stroke Foundation of Ontario
($267,144 2004-2008)
Centre for the Investigation of Neuroplasticity and
Developmental Disorders Snead OC, Taylor MJ,
Salter M, Josselyn S, Westall C, Dennis M,
Tannock R, Sled J, Cheyne D, Campbell M.
Canadian Foundation for Innovation
($15,709,086 2006-2011)
Characterization of factors and mechanisms that
explain the association between physical activity
and lung health in cystic fibrosis: Does muscle
function play a role? Ratjen F, Coates A, Tein I.
Canadian Cystic Fibrosis Foundation ($158,000
2006-2008)
Childhood stroke project: Ontario needs
assessment for childhood stroke. deVeber G.
Ontario Ministry of Health and Long-Term Care
($185,000 2005-2007)
Cognitive behavioural therapy as a novel
approach to the management of dystonia in
children: A pilot study. Soman T, Logan W, Chen
R, O’Driscoll H. SickKids Foundation ($4,500
2007-2008)
Evaluating research-based early intervention for
children at risk for reading and academic failure.
Lovett MW, De Palma M, Frijters JC. Provincial
Centre of Excellence for Child and Youth Mental
Health at CHEO ($148,500 2005-2007)
Genetics of reading disabilities. Barr CL, Tannock
R, Lovett MW, Humphries TW. Canadian Institutes
of Health Research ($898,643 2002-2007)
Health-related quality of life in children with
epilepsy: the first two years after diagnosis
through parents’ eyes. Smith ML, NixonSpeechley K, Camfield C, Wiebe S, Zou G, Levin
S. Canadian Institutes of Health Research
($393,692 2003-08)
Iatrogenic Effects of Stimulant medication on
sleep in children with ADHD. Corkum P, Weiss S.
Canadian Institutes of Health Research
($295,000 2006)
ICES paediatric linkage project. deVeber G, To T,
Zak M. Ontario Ministry of Health and Long-Term
Care, Integrated Policy and Planning Research
Unit ($30,000 2006-2007)
Identification of genetic causes of paediatric
neurological conditions and using these to
uncover the cellular pathways involved and to
determine the ways in which they are disturbed.
Minassian BA. Canada Research Chairs Program
($478,585 2006-2011)
Impact of non-invasive ventilation on children and
adolescents with neuromuscular conditions.
MacLusky I, Katz S, Banwell B, Nicholas D, Vajsar
J, Keilty-Lau K, Mitchell M, Boyd J, Anderson P,
Balthazor M. SickKids Foundation ($70,000
2002-2007)
Measurement and modulation of brain plasticity in
paediatric stroke using transcranial magnetic
stimulation. deVeber G, Kirton A. Canadian Stroke
Consortium Research Committee ($26,600
2006-2007)
MEB Diseases. Vajsar J. SickKids Foundation
($37,000 2006-2007)
Molecular basis of Lafora bodies (starch formation
in the brain ) and Lofora’s progressive myoclonus
epilepsy. Minassian BA, Ackerley CA, Scherer SW,
Lohi H. Canadian Institutes of Health Research
($1,146,830 2006-2011)
Multimodal neuroimaging of frontal lobe cognitive
function in children. Taylor MJ, Donner EW, Pang
EW. Canadian Institutes of Health Research
($466,335 2006-2011)
Multiple-component remediation for struggling
middle school readers. Morris R, Lovett MW,
Sevcik R, Frijters JC. Institute of Education
Sciences (US$2,882,630 2006-2010)
Multi-site pediatric network for fMRI mapping in
children. Gaillard WD, Donner EJ. American
Epilepsy Society ($78,000 2005-2007)
Murine knockout model of 4-hydroxybutyric
aciduria, Snead OC III. National Institutes of
Health ($587,500 USD 2006-2011)
Systemic oxygen transport and neurologic
outcomes after Norwood. Arsdell G, Otsubo, H.
The Heart and Stroke Foundation ($118,000
2006-2008)
Murine succinate semialdehyde Dehydrogenase
deficiency: An epileptic disorder with elevated
CNS GABA. Snead OC. Epilepsy Foundation/
Partnership for Pediatric Epilepsy Research
($100,000 2003-2006)
Neuroimaging the development of frontal lobe
cognitive function in autism. Taylor MJ, Roberts W,
Donner EJ, Shroff MM, Bayless SJ. National
Alliance for Autism Research (US$115,907
2006-2008)
Neuroimaging. Snead OC III. Ontario Research
Development Challenge Fund ($800,000
2001-2006)
Neuromagnetic imaging methods for realistic
models of brain activity. Cheyne D, Otsubo H,
Taylor MJ. Canadian Institutes of Health Research
($114,806 2006)
Physical activity, sport and health competition.
Schneiderman-Walker J, Longmuir P, Banwell B,
Beyenne J. Canadian Institutes of Health
Research, Institute of Musculoskeletal Health and
Arthritis – Seed Grant ($64,985 2007-2008)
The practice of paediatric movement disorders
amongst paediatricians. Soman T, MacGregor D.
SickKids Foundation ($500 2006-2008)
The role of carnitine transporters in sperm motility
and maturation and male fertility. Tein I.
Physicians’ Services Incorporated Foundation
($166,000 2003-2006)
The Ts65Dn mice model. Cortez MA. SickKids
Foundation, Down Syndrome Fund ($5,000
2005-2007)
Towards targeted intervention for specific cognitive
deficits in children with attention deficit
hyperactivity disorder and comorbid reading
disorder. Tannock R, Swanson JM, Lovett MW,
Benson NJ, Ickowicz A. National Institute of
Mental Health (US$450,600 2003-2006)
Towards the correction of Rett-like behaviour in
MeCP2-deficient mice by exogenous gene delivery.
Snead OC III. Canadian Institutes of Health
Research ($585,685 2004-2009)
Restracom training fellowship, post-doctoral
fellowship stipend for Greg Wells PhD. Tein I,
Coates A. SickKids Foundation ($73,000
2005-2007)
Treating Lafora disease with the ketogenic diet.
INMHA Fellowship Award for post-doctoral fellow
Miles Thompson. Minassian BA. Epilepsy
Canada/Canadian Institutes of Health Research
($120,000 2005-2008)
Role of the carnitine/organic cation transporters
in the mammary gland and implications for the
suckling infant Tein I. Mead-Johnson Grant
($28,500 2007-2008)
Unravelling the pathogenesis of the autophagic
vacuolar myopathies. Minassian BA, Ackerley C,
Manolson MF. Canadian Institutes of Health
Research ($779,395 2007-2012)
Seed grant funding for multidisciplinary research
projects. deVeber G, Taylor, M, Shroff M.
Department of Medical Imaging, University of
Toronto ($70,000 2006-2008)
Validation of accelerometry as a measure of
physical activity and inactivity in children with
chronic disease. Feldman B, Stephens S, Takken
T, Van der Net J, Tremblay M, Eslinger D, Bigger W,
Wright V, Validation of the NIH Stroke Scale in
Children. deVeber G, Ichord R. NINDS ($45,000
2006-2009)
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
85
Division Head
Dr. Ran Goldman
Dr. William Mounstephen Dr. Shauna Jain
Dr. Anna Jarvis
Full-Time
Dr. Kelly Keogh
Dr. Susanna Benseler
Dr. Luba Komar
Dr. Kathy Boutis
Dr. Amina Lalani
Dr. Kevin Chan
Dr. Angelo Mikrogianakis
Dr. Stephen Freedman
Dr. Bruce Minnes
Dr. Jonathan Pirie
Dr. Savithiri Ratnapalan
Dr. Susan Schneeweiss
Dr. Suzanne Schuh
Dr. Dennis Scolnik
Dr. Jennifer
Thull-Freedman
Part-Time
Dr. Sherry Baine
Dr. Carolyn Calpin
Dr. Joseph Copeland
Dr. Anh Do
Dr. Michael Falk
Dr. Janine Flanagan
Dr. John Freedman
Dr. Claudio Fregonas
Dr. Sabine George
Dr. Cara Gilman
Dr. Peter Glazer
Dr. Donna Goldenberg
Dr. Massoud Grouhi
Dr. Shuja Hafiz
Dr. Mark Handley-Derry
Dr. Leah Harrington
Dr. Nicole Inch
Dr. Ronik Kanani
Dr. Eddy Lau
Dr. Yen Le
Dr. Patricia Linders
Dr. Trent Mizzi
Dr. Sanjay Mehta
Paediatric Emergency Medicine
DIVISIONAL OVERVIEW
The division has an active three-year academic fellowship
program. The Royal College of Physicians and Surgeons has fully
accredited our fellowship program. In addition, we have a number
of clinical departmental fellows from around the world spending
a year with us further developing their paediatric emergency
medicine knowledge and skills. The division continues to run
Paediatric Life Support Courses (PALS and APLS). We also have
a well-developed weekly half-day of educational activities for
trainees and all Health care providers in the Emergency
Department. In the fall the division will present the fourth annual
Paediatric Emergency Medicine Update which in the past three
years has been an overwhelming success.
All of these will allow us to provide more efficient and effective
care to our patients. In addition we look forward to the
redevelopment of the physical plant. This redevelopment will
ensure that the ED at SickKids remains a leader in paediatric
emergency care.
Research in the division remains clinically focused, covering a
wide range of topics from respiratory disease acute care
management, orthopaedic injuries, pain and sedation, to drug
errors. Research done within the division continues to be
presented nationally and internationally with publications in peerreviewed journals. Overall a substantial increase in clinical
research activities has resulted which has set us on par with the
other North American leaders in Paediatric Emergency Medicine.
Dr. Kathy Boutis and Joanna Crudden, Research Coordinator
The Emergency Department (ED) at The Hospital for Sick
Children provides acute care to children who are ill or who have
been injured. We are both the primary care centre for children
in Toronto, plus the tertiary referral centre for the Greater
Toronto Area (GTA), in addition to being the designated
Paediatric Trauma Centre for the GTA. The division currently has
19 full-time staff, the majority of whom are recertified in
paediatrics and paediatric emergency medicine, plus a cadre
of part-time paediatricians. Over the last year we have
introduced a number of innovative clinical processes such as
two-tier triage, an urgent care clinic and soon will be introducing
a remodelling of our team system.
Dr. Steven Moss
Dr. Patricia Neelands
Dr. Carole O’Beirne
Dr. Linda Pedder
Dr. Jennifer Riley
Dr. Lillian Rojnica
Dr. Domenick Shelton
Dr. Heshy Sturm
Dr. Rahim Valani
Dr. Jeff Weisbrot
Dr. Sheldon Wise
Dr. Hirotaka Yamashiro
Cross-Appointees
Dr. Eyal Cohen
Dr. Astrid Guttmann
Dr. Jonathan Tolkin
Dr. Hilary Whyte
Dr. Jamie Hutchison
Clinical Fellows
Dr. Samim Al-Qadhi
Dr. Sam Deiratany
Dr. Yaron Finkelstein
Dr. Silvio Gonzalez
Dr. Maria Oliva
Dr. Joanne Paul
Dr. Rodica Retezar
Dr. Chris Ricks
Research Fellows
Dr. Abdullah Al-Dhafian
Dr. Faraj Alharbi
Dr. Nesrin Alharthy
Dr. Alawi Baaboud
Dr. Seen Chung
Dr. Vered Gazit
Dr. April Kam
Dr. Melissa Parker
Dr. Ayelet Rimon-Babad
Administrative Staff
Jo Azarraga
Joanna Barnes
Dana Doll
Viki Dukic
Ritsa Iriotakis
Sandra Miller
Patricia Nedanovsk
Majda Savaglio
Andrew Serrano
Nicole Winters
Benseler S: Clinical Recognition Award, Division of
Paediatric Emergency Medicine, The Hospital for
Sick Children, 2007.
Boutis K: Runner up for Best Researcher in The
Hospital for Sick Children Emergency Department,
2007.
Freedman S: Clinical Recognition Award-MD,
Runner Up. Division of Paediatric Emergency
Medicine, 2006.
Freedman S: Research Recognition Award-MD,
Division of Paediatric Emergency Medicine, The
Hospital for Sick Children, 2006.
Jarvis A: Dr. JC Fallis Clinical Teaching Award,
Division of Emergency Medicine, The Hospital for
Sick Children, 2007.
Schneeweiss S: Nominee for Colin Woolf Award
for Excellence in Course Coordination, 2006.
Schuh S: Research Recognition Award-MD,
Division of Paediatric Emergency Medicine, The
Hospital for Sick Children, 2007.
Gaboury I, Merali Z, Mackenzie AE, Hutchison JS:
Hypoxia alters the expression of inhibitor of
apoptosis Proteins after brain trauma in the
mouse. Journal of Neurotrauma 2007: 24:
pp 338-353.
Schuh S: Physician Research Award for Career
Excellence Nominee, University of Toronto, Faculty
of Medicine, 2007.
Goldman RD: Alternating ibuprofen and
acetaminophen may be more effective in the
treatment of fever in children. Journal of Pediatrics
[Invited Commentary] 2006: 149: pp 140-141.
Scolnik D: Runner up for Clinical Recognition
Award in Recognition of Excellence in Outstanding
Effort and Contribution to the Emergency
Department, 2007.
Goldman RD, Amin P, Macpherson A: Language
and length of stay in the pediatric emergency
department. Pediatric Emergency Care 2006: 22:
pp 640-643.
Scolnik D: Runner up for Clinical Teaching Award –
Staff Physician, Division of Paediatric Emergency
Medicine, 2007.
Goldman RD, Ong M, Macpherson A:
Unscheduled return visits to the pediatric
emergency department – One year experience.
Pediatric Emergency Care 2006: 22: pp 545-549.
PUBLICATIONS
Lalani A: Continuing Education Award for
Excellence in Course Coordination, Paediatric
Emergency Medicine Conference, Department of
Paediatrics, The Hospital for Sick Children, 2006.
Al Ansari K, Howard A, Boutis K: Minimally
angulated wrist fractures: Is immobilization
without casting enough? Canadian Journal of
Emergency Medicine 2007: 9: pp 9-15.
Gupta V, Goldman RD: Pediatric pearls:
Emergency contraceptive options available for
adolescents. Canadian Family Physician 2006:
52: pp 1219-1220.
Mehta S: PAIRO Award for Clinical Excellence in
Teaching, Runner-Up, 2007.
Boutis K, Schuh S, Babyn P, Alman B, Willan A,
Narayanan U: Randomized controlled trial of
casting vs. air-stirrup ankle brace in children with
acute low risk ankle fractures. Pediatrics 2007:
119: pp 1256-1263.
Joffe A, Lalani A: Injury admissions to pediatric
intensive care are predictable and preventable:
A call to action. Journal of Intensive Care
Medicine 2006: 21: pp 227-234.
Breakey VR, Pirie J, Goldman RD: Pediatric and
emergency medicine residents’ attitudes and
practices for analgesia and sedation during
lumbar puncture in pediatric patients. Pediatrics
2007: 119: pp 631-636.
Kelly WN, Arellano FM, Barnes J, Bergman U,
Edwards RI, Fernandez AM, Freedman SB,
Goldsmith DI, Huang KA, Jones JK, McLeay R,
Moore N, Stather RH, Trenque T, Troutman WG,
Puijenbroek E, Williams F, Wise RP: Guidelines for
submitting adverse event reports for publication.
Drug Safety 2007: 30: pp 367-373.
Mehta S: James C. Fallis Teaching Award for
Paediatric Emergency Medicine Staff Physician
Presentation, Runner-Up, 2007.
Minnes B: Clinical Teaching Award for Excellence
in Clinical Teaching – Staff Physician, Division of
Paediatric Emergency Medicine, The Hospital for
Sick Children, 2007.
Mikrogianakis A: Anna Jarvis Award for
Postgraduate Teaching Excellence in Emergency
Medicine, University of Toronto, 2007.
Mounstephen W: Winning Poster Award Noise
Levels in the ED. 1st Annual Patient Safety and
Quality Academic Day, The Hospital for Sick
Children, 2007.
Pirie J: James C. Fallis Teaching Award, RunnerUp, Division of Paediatric Emergency Medicine,
The Hospital for Sick Children, 2007.
Ratnapalan S: David Fear Fellowship Award for
Continuing Medical Education, University of
Toronto, 2006.
Schneeweiss S: Department of Paediatrics
Continuing Education Award, The Hospital for Sick
Children, 2007.
88
DEPARTMENT OF PAEDIATRICS
Cheng A, Ratnapalan S: Improving the palatability
of activated charcoal in paediatric patients.
Pediatric Emergency Care 2007: 23: pp 384-386.
Cohen-Kerem R, Ratnapalan S, Xu Z, Chandra R,
Ito S: The attitude of physicians toward cold
remedies for upper respiratory infection in infants
and children: a questionnaire survey. Clinical
Pediatrics 2006: 45: pp 828-834.
Constantine E, Steele DW, Eberson C, Boutis K,
Amanullah S, Linakis JG: The management of
forearm fracture reduction in children:
Variations in practice among pediatric emergency
departments in North America. Pediatric
Emergency Care 2007: 23: pp 209-211.
Doria AS, Moineddin R, Kellenberger CJ, Epelman
M, Beyene J, Schuh S, Babyn PS, Dick PT: US
or CT for diagnosis of appendicitis in children and
adults? A meta-analysis. Radiology 2006: 241:
pp 83-94.
ANNUAL REPORT 2006-07
Kelly WN, Arellano FM, Barnes J, Bergman U,
Edwards RI, Fernandez AM, Freedman SB,
Goldsmith DI, Huang KA, Jones JK, McLeay R,
Moore N, Stather RH, Trenque T, Troutman WG,
Puijenbroek E, Williams F, Wise RP: Guidelines for
submitting adverse event reports for publication.
Pharmacoepidemiology and Drug Safety 2007:
16: pp 581-587.
Khoosal D, Goldman RD: Pediatric pearls: Vitamin
E for treating children’s scars. Does it help reduce
scarring? Canadian Family Physician 2006: 52:
pp 855-856.
Klein-Kremer A, Goldman RD: Analgesia
for children with acute abdominal pain in the
emergency department. Israeli Journal of
Emergency Medicine 2006: 6: pp 53-56.
Dr. Kevin Chan
HONOURS AND AWARDS
Klein-Kremer A, Goldman RD: Opioid
administration for acute abdominal pain in the
pediatric emergency department. Journal of
Opioid Management 2007: 3: pp 11-14.
Mosko JD, Goldman RD: PRETx update: White
blood cell count in the diagnosis of pediatric
appendicitis. International Pediatrics 2007: 22:
pp 38-40.
Kozer E, Scolnik D, Jarvis A, Koren G: The effect of
detection approaches on the reported incidence
of tenfold errors – An overview. Drug Safety 2006:
29: pp 169-174.
Nasr A, Mikrogianakis A, McDowall D, Wales P:
External validation and modification of a pediatric
trauma triage tool. Journal of Trauma 2007: 62:
pp 606-609.
Kozer E, Scolnik D, MacPherson A, Rauchwerger
D, Koren G: The effect of a short tutorial on the
incidence of prescribing errors in pediatric
emergency care. Canadian Journal of Clinical
Pharmacology 2006: 13: pp e285-e291.
Ratnapalan S, Schneeweiss S: Guidelines to
practice: The process of planning and
implementing a paediatric sedation program.
Pediatric Emergency Care 2007: 23: pp 262-266.
Lalani A: Pediatric Emergency Medicine in Uganda.
Royal College Outlook 2006: 3: pp 56-57.
Maimon M, Ratnapalan S, Do A, Kirsh J, Wilson
GJ, Benson L: Cardiac perforation 6 weeks after
percutaneous atrial septal defect repair using
an Amplatzer septal occluder. Pediatrics 2006 5:
pp 1572-1575.
Mater A, Dirks P, Goldman RD: PRETx update –
Ventriculoperitoneal shunt dysfunction.
International Pediatrics 2006: 21: pp 184-185.
Mehta SV: Review of recent AAP bronchiolitis
guidelines. ACEP Section of Paediatric Emergency
Medicine Newsletter 2007: 18.
Mehta SV: Paediatric minor head injuries. ACEP
Section of Paediatric Emergency Medicine
Newsletter 2007: 18.
Mikrogianakis A, Shaye RE, Griffin P, Lockwood J,
Gendron NH, Gaboury I, Merali Z, MacKenzie AE,
Hutchison JS: Hypoxia alters the expression of
inhibitor of apoptosis proteins after brain trauma
in the mouse. Journal of Neurotrauma 2007: 24:
pp 338-353.
Schneeweiss S, Ratnapalan S: Impact of a multifaceted paediatric sedation course: self-directed
learning versus a formal continuing medical
education course to improve knowledge of
sedation guidelines. Canadian Journal of
Emergency Medicine 2007: 9: pp 93-100.
BOOKS AND BOOK CHAPTERS
Benseler S: Rheumatologic emergencies. In:
Hospital for Sick Children Handbook of Pediatric
Emergency Medicine (Lalani A, Schneeweiss S,
eds). Jones and Bartlett Publishers, Sudbury,
MA, 2007.
Benseler S: Kawasaki Disease In: In: Hospital for
Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Do A: Pelvic Inflammatory disease. In: Hospital for
Sick Children Handbook of Paediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Do A: Gynecologic emergencies. In: Hospital for
Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Schuh S, Dick P, Stephens D, Hartley M, Khaikin
S, Coates A: High-dose inhaled fluticasone does
not replace oral prednisolone in children with mild
to moderate acute asthma. Pediatrics 2006: 118:
pp 644-650.
Freedman SB: Fluid and electrolyte disorders.
In: Hospital for Sick Children Handbook
of Pediatric Emergency Medicine (Lalani A,
Schneeweiss S, eds). Jones and Bartlett
Publishers, Sudbury, MA, 2007.
Schuh S, Lalani A, Allen U, Manson D, Babyn P,
Stephens D, MacPhee S, Mokanski M, Khaikin S,
Dick P: Utility of chest radiographs in infants with
acute bronchiolitis. Journal of Pediatrics 2007:
150: pp 429-33.
Goldman RD, Mace, SE: Local anesthetics:
Injectable agents. In: Critical Decisions in
Emergency Medicine. American College of
Emergency Physician, Dallas, Texas, 2006.
Schwartz JR, Goldman RD: PRETx update –
Topiramate for prophylactic treatment of pediatric
migraine. International Pediatrics 2006: 21:
pp 244-246.
Scolnik D, Coates AL, Stephens D, Da Silva Z,
Lavine E, Schuh S: Controlled delivery of high vs
low humidity vs mist therapy for croup in
emergency departments: A randomized controlled
trial. Journal of the American Medical Association
2006: 295: pp 1274-1280.
Harrington L, Schneeweiss S: Gastroenteritis and
oral rehydration. In: Hospital for Sick Children
Handbook of Pediatric Emergency Medicine
(Lalani A, Schneeweiss S, eds). Jones and Bartlett
Publishers, Sudbury, MA, 2007.
Harrington L: Constipation. In: Hospital for Sick
Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Dr. Savithiri Ratnapalan
Scolnik D: Humidity therapy for croup. Italian
Journal of Pediatrics 2006: 32: pp 330-332.
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
91
Harrington L: Abdominal emergencies. In: Hospital
for Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Jarvis A, Kirby M: Sickle Cell Disease. In: Hospital
for Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Harrington L: Gastrointestinal bleeding. In: Hospital
for Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Jarvis A: Altered level of consciousness. In:
Hospital for Sick Children Handbook of Pediatric
Emergency Medicine (Lalani A, Schneeweiss S,
eds). Jones and Bartlett Publishers, Sudbury,
MA, 2007.
Harrington L: Urologic emergencies. In: Hospital
for Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Harrington L: Limp. In: In: Hospital for Sick
Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Jain S: Toxicology Part 1: Approach to ingestions.
In: Hospital for Sick Children Handbook of
Pediatric Emergency Medicine (Lalani A,
Schneeweiss S, eds). Jones and Bartlett
Publishers, Sudbury, MA, 2007.
Jarvis A: Intraosseous access. In: Hospital for Sick
Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Jarvis A: Child maltreatment. In: Hospital for Sick
Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Keogh KA, Mason A: Osteomyelitis and septic
arthritis. In: Hospital for Sick Children Handbook
of Pediatric Emergency Medicine (Lalani A,
Schneeweiss S, eds). Jones and Bartlett
Publishers, Sudbury, MA, 2007.
Jain S: Toxicology Part 2: Specific toxins. In:
Hospital for Sick Children Handbook of Pediatric
Emergency Medicine (Lalani A, Schneeweiss S,
eds). Jones and Bartlett Publishers, Sudbury,
MA, 2007.
Komar L: Cardiac emergencies. In: Hospital for
Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Jarvis DA: Pediatric triage. In: Hospital for Sick
Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Lalani A: Fever and tropical infections. In: Hospital
for Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Jarvis DA: Shock. In: Hospital for Sick Children
Handbook of Pediatric Emergency Medicine
(Lalani A, Schneeweiss S, eds). Jones and Bartlett
Publishers, Sudbury, MA, 2007.
Lalani A: Foreign bodies. In: Hospital for Sick
Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Jarvis A: Head injury. In: Hospital for Sick Children
Handbook of Pediatric Emergency Medicine
(Lalani A, Schneeweiss S, eds). Jones and Bartlett
Publishers, Sudbury, MA, 2007.
Lalani A: Diabetic emergencies. In: Hospital for
Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Lalani A: Otitis media. In: Hospital for Sick
Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Lalani A. Valani R: Hematologic emergencies. In:
Hospital for Sick Children Handbook of Pediatric
Emergency Medicine (Lalani A, Schneeweiss S,
eds). Jones and Bartlett Publishers, Sudbury,
MA, 2007.
Lalani A, Schneeweiss S: Hospital for Sick
Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
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DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
Lalani A, Schneeweiss S, Shamsah A: Burns. In:
Hospital for Sick Children Handbook of Pediatric
Emergency Medicine (Lalani A, Schneeweiss S,
eds). Jones and Bartlett Publishers, Sudbury,
MA, 2007.
Mehta SV: Hyperthermia/hypothermia. In:
Handbook of Pediatric Emergency Medicine
(Lalani A, Schneeweiss S, eds). Jones & Bartlett,
Sudbury, MA, 2007
Mehta SV: Psychiatric emergencies. In: Hospital
for Sick Children Handbook of Pediatric
Emergency Medicine (Lalani A, Schneeweiss S,
eds). Jones and Bartlett Publishers, Sudbury,
MA, 2007.
Mehta SV: Syncope. In: Hospital for Sick Children
Handbook of Pediatric Emergency Medicine
(Lalani A, Schneeweiss S, eds). Jones and Bartlett
Publishers, Sudbury, MA, 2007.
Mikrogianakis A: Pediatric trauma. In: Hospital for
Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Mikrogianakis A: Ventriculoperitoneal shunts. In:
Hospital for Sick Children Handbook of Pediatric
Emergency Medicine (Lalani A, Schneeweiss S,
eds). Jones and Bartlett Publishers, Sudbury,
MA, 2007.
Mikrogianakis A, Ricks C: Common emergency
procedures. In: Hospital for Sick Children
Handbook of Pediatric Emergency Medicine
(Lalani A, Schneeweiss S, eds). Jones and Bartlett
Publishers, Sudbury, MA, 2007.
Minnes B: Paediatric appendicitis. In: Hospital for
Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Mounstephen W: Adrenal crisis. In: Hospital for
Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Mounstephen W: Dental emergencies. In: Hospital
for Sick Children Handbook of Pediatric
Emergency Medicine (Lalani A, Schneeweiss S,
eds). Jones and Bartlett Publishers, Sudbury,
MA, 2007.
Pirie J: Bite wounds. In: Hospital for Sick Children
Handbook of Pediatric Emergency Medicine
(Lalani A, Schneeweiss S, eds). Jones and Bartlett
Publishers, Sudbury, MA, 2007.
Schneeweiss S. Orthopedic injuries. In: Hospital
for Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Pirie J: Oropharyngeal infections. In: Hospital for
Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Schneeweiss S. Pain management. In: Hospital for
Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Pirie J: Fever. In: Hospital for Sick Children
Handbook of Pediatric Emergency Medicine
(Lalani A, Schneeweiss S, eds). Jones and Bartlett
Publishers, Sudbury, MA, 2007.
Schneeweiss S. Meningitis and encephalitis. In:
Hospital for Sick Children Handbook of Pediatric
Emergency Medicine (Lalani A, Schneeweiss S,
eds). Jones and Bartlett Publishers, Sudbury,
MA, 2007.
Ratnapalan S: Hypertensive emergencies in
children. In: Hospital for Sick Children Handbook
of Pediatric Emergency Medicine (Lalani A,
Schneeweiss S, eds). Jones and Bartlett
Publishers, Sudbury, MA, 2007.
Ratnapalan S, Schneeweiss S: Procedural
sedation. In: Hospital for Sick Children Handbook
of Pediatric Emergency Medicine (Lalani A,
Schneeweiss S, eds). Jones and Bartlett
Publishers, Sudbury, MA, 2007.
Riley J: Street drugs. In: Hospital for Sick Children
Handbook of Pediatric Emergency Medicine
(Lalani A, Schneeweiss S, eds). Jones and Bartlett
Publishers, Sudbury, MA, 2007.
Rogovik AL, Goldman RD: Hypnosis as treatment
for pain. In: Pain Management & Sedation
(Mace SE, Ducharme J, Murphy MF, eds).
McGraw-Hill Publishing, Medical Publishing
Division, New York, 2006.
Schneeweiss S. Cardiopulmonary resuscitation. In:
Hospital for Sick Children Handbook of Pediatric
Emergency Medicine (Lalani A, Schneeweiss S,
eds). Jones and Bartlett Publishers, Sudbury,
MA, 2007.
Schneeweiss S. Newborn emergencies. In:
Hospital for Sick Children Handbook of Pediatric
Emergency Medicine (Lalani A, Schneeweiss S,
eds). Jones and Bartlett Publishers, Sudbury,
MA, 2007.
Schneeweiss S. Sinusitis. In: Hospital for Sick
Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Schneeweiss S. Pediatric sedation of children in
the emergency setting. In: Encyclopedia of Pain
(Schmidt RF and Willis WD eds). Springer-Verlag,
Berlin, Heidelberg, 2007.
Schuh S: Asthma. In: Hospital for Sick Children
Handbook of Pediatric Emergency Medicine
(Lalani A, Schneeweiss S, eds). Jones and Bartlett
Publishers, Sudbury, MA, 2007.
Schuh S: Croup. In: Hospital for Sick Children
Handbook of Pediatric Emergency Medicine
(Lalani A, Schneeweiss S, eds). Jones and Bartlett
Publishers, Sudbury, MA, 2007.
Schuh S: Bronchiolitis. In: Hospital for Sick
Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Scolnik D: Urinary tract infections. In: Hospital for
Sick Children Handbook of Pediatric Emergency
Medicine (Lalani A, Schneeweiss S, eds). Jones
and Bartlett Publishers, Sudbury, MA, 2007.
Thull-Freedman JD: Renal emergencies. In:
Hospital for Sick Children Handbook of Pediatric
Emergency Medicine (Lalani A, Schneeweiss S,
eds). Jones and Bartlett Publishers, Sudbury,
MA, 2007.
Warren D, Jarvis DA, Bullard M, Leblanc L, Cotton
D, Policicchio C: Canadian Triage and Acuity Scale
(CTAS) Training Manual for Combined Adult &
Paediatric Triage Educational Program, 2006.
FUNDING
A randomized controlled trial of casting versus
wrist splint in children with minimally angulated
distal radius fractures in children. Boutis K,
Howard A, Babyn P, Willan A. SickKids Foundation
($129,775 2006-2008)
Emergency Department Rapid Intravenous
Rehydration (RIVR) for pediatric gastroenteritis: A
randomized controlled trial. Freedman S, Parkin P,
Willan A, Schuh S. Physicians’ Services
Incorporated Foundation ($165,000 2006-2008)
Evaluating addiction medicine curriculum in Saudi
Arabia. AL-Shamarry SA, Ratnapalan S. Ministry
of Health, Saudi Arabia ($10,000 2006-2007)
Impact of oximetry on hospitalization in acute
bronchiolitis. Schuh S, Freedman S, Coates A,
Parkin P, Allen U, Willan A, Ungar W, Da Silva Z.
Physicians’ Services Incorporated Foundation
($163,000 2007-2009)
Isotonic versus hypotonic IV maintenance fluids in
children: A randomized controlled trial. Freidman
JN, Freedman SB, Beck C, Geary D. The Hospital
for Sick Children Paediatric Consultants
Partnership’s Grant ($9,956 2007-2008)
Medication error reduction initiative in the
emergency department. Ratnapalan S, Jarvis A.
The Hospital for Sick Children Paediatric
Consultants Partnership’s Grant ($5,837
2006-2007)
Predictors for diagnostically accurate ultrasound
in children with suspected appendicitis. Doria A,
Schuh S, Cheng A, Langer J, Tomlinson G.
SickKids Foundation ($128,000 2007-2009)
Programme for Global Paediatric Research
Workshop/Symposium, Toronto, Ontario. Chan K,
Zipursky A, Manley M. Canadian International
Development Agency ($30,800 2007)
The impact of an Emergency Department and
community based gastroenteritis education
protocol on knowledge and emergency
department utilization. Freedman SB. Pediatric
Consultants Educational Research Grant ($4,527
2005-2007)
The MAST project: Magnesium for sickle cell trial.
Goldman RD, Kirby-Allen M, Mounstephen W,
Friedman J. Physicians’ Services Incorporated
Foundation ($157,000 2006-2008)
Workshop on NGO/academia collaboration in
global child health. Chan K. Trudeau Foundation
($6,300, 2007)
Paediatric Medicine
DIVISIONAL OVERVIEW
It was with tremendous sadness that we mourned the passing
of Dr. Norman Saunders in March 2007 after a courageous and
dignified fight against illness. Dr. Saunders set a very high
standard for paediatricians at SickKids and even in the last years
of his illness continued to make a tremendous contribution to the
hospital to which he was so loyal and dedicated over the course
of his thirty year career. Thanks to his efforts together with a
group of his friends and former patients, a Complex Care Initiative
was launched through the SickKids Foundation and has raised
over 1.3 million dollars to go toward academic study and research
into improving the care delivered to the complex paediatric
patient. He also co-edited two books for parents, on behalf of the
Division of Paediatric Medicine, which were published in the final
year of his outstanding career.
We also said farewell to Dr. Marcellina Mian after 25 years at
SickKids and wish her well in her new leadership role in
paediatric medical education in Qatar. Marcie has been a pioneer
in the field of child abuse, is internationally respected as an
expert in the area, and led the International Child Abuse Society
as president a few years ago. She has led the hospital’s
undergraduate education program admirably. She will be missed
and leaves big shoes to fill! Congratulations to Dr. Stacey
Bernstein who was appointed as the Director of Undergraduate
Medical Education for the hospital and has taken over from
Dr. Mian in this capacity.
Division Head
Dr. Jeremy Friedman
Full-Time
Dr. Hosanna Au
Dr. Carolyn Beck
Dr. Stacey Bernstein
Dr. Catherine Birken
Dr. Trey Coffey
Dr. Emma Cory
Dr. Robert Hilliard
Dr. Sanjay Mahant
Dr. Marcellina Mian
Dr. Patricia Parkin
Dr. Elena Pope
Dr. Michelle Shouldice
Dr. Susan Tallett
Dr. Michael Weinstein
Major Part-Time
Dr. Eyal Cohen
Dr. Mark Feldman
Dr. Saul Greenberg
On the clinical side, the Paediatric Medicine Inpatient Units
remained extremely busy with responsibility for over 20 percent
of the hospital inpatient population. There were a number of new
quality initiatives piloted on the Paediatric Medicine wards
including the MCAP utilization tool and medication reconciliation
process, and a number of innovative restructuring projects aimed
at improving efficiencies. The first Paediatric Medicine 7th
floor inpatient Retreat was held for all members of the team and
it was highly successful. Dr. Sanjay Mahant and Sherri Adams
(nurse practitioner) both won awards for their clinical contribution
in palliative care.
The Division of Paediatric Medicine continues to contribute
much to the department’s educational enterprise at both
the undergraduate and postgraduate levels through the full-time
faculty as well as the tremendous efforts of the community
paediatricians. These contributions are not only impressive
quantitatively in terms of hours spent in medical education,
but also qualitatively in terms of leadership, teaching awards
and evaluations.
Congratulations to Dr. Susan Tallett who has been appointed as
the first chief of the hospital’s new Institute of Learning.
Dr. Bernstein has taken over as Director, Undergraduate Medical
Education. It is notable that of the 22 core rotations through
which the paediatric residents rotate in their three core years of
training, the first and second highest overall ratings were for
the rotations on the Paediatric Medicine inpatient ward service
for first and third year residents.
The Harry Bain Award for excellence in clinical teaching was
awarded to Dr. Michael Weinstein (Director, Inpatient Paediatric
Medicine) and the Subspecialty Teaching Award was awarded
to Dr. Elena Pope (Director, Section of Paediatric Dermatology).
The Paediatric Medicine fellowship program continues to grow
and currently there are 10 Canadian and international fellows
participating in the various streams of fellowship including
Academic General Paediatrics, Dermatology, and Hospitalist
fellowships. A number are pursuing Masters degrees in medical
education, clinical epidemiology and bioethics.
Dr. Astrid Guttmann
Dr. Moshe Ipp
Dr. Sheila Jacobson
Dr. Charlotte Moore
Dr. Michael Peer
Dr. Norman Saunders
Dr. Miriam Weinstein
Part-Time
Dr. Tony Barozzino
Dr. Salvatore Cammisuli
(Dermatology)
Dr. Paul Dick
Dr. Nhung Ho
(Dermatology)
Dr. Alex Levin (SCAN)
Dr. Michael Sgro
Dr. Christine Webster
(Dermatology)
Associates
Dr. Michelle Farine
Dr. Beth D. Gamulka
Dr. Hartley A. Garfield
Dr. Charlotte Moore with Dr. Sarah Wan (locum) and Dr. Navneet Sharma (fellow)
The 2006-07 academic year was another excellent year for the
Division of Paediatric Medicine. In January, we welcomed two new
faculty members. Dr. Hosanna Au, a graduate of the University of
Toronto and the paediatric residency program at SickKids joined
as a member of the Section of SCAN, after an 18 month locum.
In addition to her SCAN responsibilities, part of her time will be
spent attending on the inpatient paediatric medicine wards in
addition to her activities in medical education. We also welcomed
Dr. Charlotte Moore who obtained her MD at Johns Hopkins and
did her paediatric residency at Harvard. She has a strong interest
in health policy and has joined our division in a major part-time
role with the rest of her time being spent with the Ontario
Ministry of Health. She will attend on the inpatient wards during
her clinical time. We look forward to productive and exciting
careers for both of them.
Dr. Morton Goldbach
Dr. Stuart Gordner
Dr. James D. Hilton
Dr. Tommy Ho
Dr. Anthony Y.T. Hui
Dr. Beverley Kupfert
Dr. Cinda B.S. Lee
Dr. S. Joseph Porepa
Dr. Percy Rajchgot
Dr. Clive J. Schwartz
Dr. David H. Shawn
Dr. Gary Sibbald
Dr. Joseph Telch
Dr. Ethel Ying
Adjunct
Dr. Ronik Kanani
Cross-appointees
Dr. Glen B. Berall
Dr. Alan Berzen
Dr. Bonnie J. Cameron
Dr. Douglas Campbell
Dr. Carlos E. Contreras
Dr. Gordon J. Donsky
Dr. Katy Driver
Dr. Leona Fishman
Dr. John S. Freedman
Dr. Lee Ann Gallant
Dr. Rose Geist
Dr. Sabine R. George
Dr. William B. Hanley
Dr. Nicole G. Inch
Dr. Jaya Islur
Dr. D. Anna Jarvis
Dr. Ian C. Kitai
Dr. Leo Levin
Dr. Patricia M. Linders
Dr. John S. Lovering
Dr. Gilbert Miller
Dr. Golda Milo-Manson
Dr. John D.M. Murray
Dr. Jay D. Rosenfield
Dr. Suzanne Schuh
Dr. Jeffrey J. Weisbrot
Dr. Sheldon A. Wise
Dr. Martin G. Wolfish
Honorary
Dr. Lionel B.H. Boxall
Dr. Michael Braudo
Dr. Andrew Chlebus
Dr. William Davidson
Dr. Till A. Davy
Dr. James Dorey
Dr. Andrew D. Duic
Dr. Anthony S.R. Duke
Dr. Thomas J. Egan
Dr. Robert Farber
Dr. Hyder H. Fazal
Dr. William Feldman
Dr. Adelaide L. Fleming
Dr. Raphael Folman
Dr. Marvin H. Gans
Dr. Katerina Haka-Ikse
Dr. Dirk W. Huyer
Dr. Martin H. Kosoy
Dr. Howard M. Langer
Dr. Michael Lester
Dr. David C. Maresky
Dr. Janette A. Milne
Dr. Paul Munk
Dr. Jack Newman
Dr. Raymond C.W. Ng
Dr. Larry B. Pancer
Dr. Evangelia
Papadouris
Dr. Helene A. Richards
Dr. Chandrakant
P. Shah
Dr. Donald Stewart
Dr. Peter G. Strachan
Dr. Robert E. Sutton
On the research side, it was a highly successful year for the
division with 25 abstracts being presented at the annual
international Pediatric Academic Society meeting in May as well
as the national Canadian Paediatric Society meeting in June. In
addition, Dr. Jonathan Maguire who will be an academic general
paediatric fellow in 2007 was selected to represent the
residency program at the annual paediatric residents competition
in Winnipeg (supervisor Dr. Patricia Parkin) and Dr. Elizabeth
Berger won a research award in the core paediatric resident
category of the department’s Annual Research Day (supervisor
Dr. Jeremy Friedman). Research Rounds occur regularly every
Thursday afternoon at lunchtime under the auspices of the
Paediatric Outcomes Research Team (PORT) and continue to
gain in popularity with a wide range of research being presented
and reviewed. A Divisional Journal Club co-ordinated by the
fellows and staff was also reinstituted this year and has
been well attended and enjoyed by all. We also welcomed
Magda Mekky as the PORT Clinical Research Project Co-ordinator
(Epidemiology) in January 2007. Details of the many peer
reviewed publications and research grants from this academic
year are listed in the next few pages.
On the advocacy side, the paediatric residents under the
supervision of Drs. Catherine Birken and Hosanna Au have been
very successful in working together with school children to produce
the Kids on Kids Health magazine which has been presented
in a number of forums including the national CPS meeting.
A new book co-edited by Drs. Jeremy Friedman and Norman
Saunders, with contributions from six of the Paediatric Medicine
faculty, entitled Canada’s Baby Care Book, was published by
Robert Rose in May is already a best seller in Canada. There are
plans to release it internationally in the upcoming year. �Caring
for Kids. The Complete Canadian Guide to Child Health’ published
by Key Porter by the same editors, with contributions from 13
Paediatric Medicine faculty has become a bestseller in Canada
since its publication in March 2006, and is now selling
internationally as well.
HONOURS AND AWARDS
Campbell D: Postgraduate Community Paediatric
Teaching Award (Postgraduate Teaching Award),
Department of Paediatrics, The Hospital for Sick
Children, Toronto, Ontario, Canada, 2007.
Saunders N: Marvin Gerstein Award (Postgraduate
Teaching Award), Department of Paediatrics,
The Hospital for Sick Children, Toronto, Ontario,
Canada, 2007.
Guttmann A: 5 year Canadian Child Health
Clinician Scientist Program Career Enhancement
Award. December, 2006-2011.
Simone A: Undergraduate Community Paediatric
Teaching Award (Undergraduate Teaching Award),
Department of Paediatrics, The Hospital for
Sick Children, Toronto, Ontario, Canada, 2007.
Garfield H: Lionel Weinstein Clerkship Teaching
Award (Undergraduate Teaching Award),
Department of Paediatrics, The Hospital for Sick
Children, Toronto, Ontario, Canada, 2007.
Mahant S: Palliative and Bereavement Care
Service Award, The Hospital for Sick Children,
Toronto, Canada, 2006.
Dr. Jeremy Friedman on rounds
Mahant S: Royal College of Physicians and
Surgeons of Canada: Clinical Traineeship Grant,
2007.
Pope E: Department of Paediatrics’ Postgraduate
Subspecialty Teaching Award, Department
of Paediatrics, The Hospital for Sick Children,
Toronto, Ontario, Canada, 2007.
Tallett S: The Charles Mickles Fellowship Award.
2007.
Weinstein Michael: Harry Bain Award
(Postgraduate Teaching Award), Department
of Paediatrics, The Hospital for Sick Children,
Toronto, Ontario, Canada, 2007.
PUBLICATIONS
Agha M, Glazier R, Guttmann A: Relationship
between social inequalities and ambulatory caresensitive hospitalizations persists for up to 9
years among children born in a major Canadian
urban center. Ambulatory Pediatrics 2007: 7:
pp 258-262.
Ardelean D, Pope E: Incontinenti pigmenti in boys:
a series and review of the literature. Pediatric
Dermatology 2006: 23: pp 523-527.
Fellows
Dr. Zia Bismilla
Dr. Mariana Boragina
Dr. Malini Dave
Dr. Perla Lansang
Dr. Irene Lara Corrales
Dr. Michael McNeely
Dr. Masooma Mohamed
Dr. Adam Rapoport
Dr. Barry Seltz
Dr. Navneet Sharma
Research Associates
Jennifer Bennie
Amina Khambalia
Dr. Colin Macarthur
Noorulain Malik
Magda Mekky
Dr. Jyothi Sehgal
Kathryn (Kate) Smith
Vineet Syan
Au H: Neonatal seizures. Paediatrics and Child
Health 2007: 12: pp 37-40.
Au H: Recurrent meningitis in a child due to occult
spinal lesion. Canadian Medical Association
Journal 2006: 175: pp 737-738.
Beck CE, Khambalia A, Parkin PC, Raina P,
Macarthur C: Does day of discharge influence
hospital readmission rates for children?
Paediatrics & Child Health 2006: 11:
pp 409-412.
Birken CS, Parkin PC, To T, Macarthur C: Trends in
unintentional injury mortality rates in Canadian
children living in census metropolitan areas:
influence of socioeconomic status. Canadian
Medical Association Journal 2006: 175:
pp 867-868.
Boragina M, Cohen E: The setting-sun
phenomenon. Canadian Medical Association
Journal 2006: 175: p 878.
Chang B, Mirabella G, Yagev R, Banh M, Mezer E,
Parkin PC, Westall CA, Buncic JR: Screening and
diagnosis of optic pathway gliomas in children
with neurofibromatosis type 1 using sweep visual
evoked potentials. Investigative Ophthalmology
and Visual Science 2007: 48: pp 2895-902.
Administrative Staff
Sarah Ahmad
Tiziana Altobelli
Josie Marcantonio
Marg Mather
Daffodil Morrison
Kathryn Robertson
Pauline Smith
Jan White
Donna Whitely
Connolly B, Mahant S: The pediatric hospitalist
and interventional radiologist: A model for clinical
care in pediatric interventional radiology. Journal
of Vascular and Interventional Radiology 2006:
17: pp 1733-1738.
Feldman M: Guiding Parents in their Search on the
Internet for High Quality Health Information. Paediatrics and Child Health 2007: 12: pp 239-240.
Friedman JN: The case for...writing case reports.
Paediatrics and Child Health 2006: 11:
pp 343-344.
Guttmann A, Razzaq A, Lindsay P, Zagorski B,
Anderson GM: Development of measures of the
quality of emergency department care for children
using a structured panel process. Pediatrics
2006: 118: pp 114-123.
Hilliard RI, Harrison C, Madden S: Ethical conflicts
and moral distress experienced by paediatric
residents during their training. Paediatrics and
Child Health 2007: 12: pp 29-35.
Ho NTC, Lansang P, Pope E: Topical imiquimod
in the treatment of infantile hemangiomas:
A retrospective study. Journal of the American
Academy of Dermatology 2007: 56: pp 63-68.
Ipp M, Cohen E, Goldbach M, Macarthur CM:
Pain response to M-M-R vaccinations in 4-6 year
old children. Canadian Journal of Clinical
Pharmacology 2006: 13: pp e296-e299.
Jao-Tan C, Pope E: Cutaneous poisoning
syndromes in children: a review. Current Opinion
in Pediatrics 2006: 18: pp 410-416.
Kwinter J, Pelletier J, Khambalia A, Pope E:
High-potency steroid use in children with vitiligo:
A retrospective study. Journal of the American
Academy of Dermatology 2007: 56: pp 947-950.
Kwinter J, Weinstein M: Plica neuropathica: Novel
presentation of a rare disease. Clinical and
Experimental Dermatology 2006: 31: pp 790-792.
Lam J, Pope E: A rash-ional approach to
recalcitrant diaper dermatitis. Paediatrics and
Child Health 2007: 12: pp 129-131.
Lieberman L, Hilliard RI: How well do pediatric
residency programs prepare residents for clinical
practice and their future careers? Medical
Education 2006: 40: pp 539-546.
MacDonald NE, Ford-Jones L, Friedman JN, Hall, J:
Preparing a manuscript for publication: A userfriendly guide. Paediatrics and Child Health 2006:
11: pp 339-344.
MacGregor D, Tallett S, MacMillan S, Gerber R,
O’Brodovich H: Clinical and education workload
measurements using personal digital assistant
based software. Pediatrics 2006: 118:
pp e985-e991.
98
DEPARTMENT OF PAEDIATRICS
MacLean JE, Mahant S, Bitnum A, Read S, Capra
M, Solomon M: Family matters: A twelve-year-old
male with respiratory symptoms, cachexia and
clubbing. Journal of Paediatrics and Child Health
2006: 42: pp 739-749.
Macpherson AK, Macarthur C, To TM, Chipman
ML, Wright JG, Parkin PC: Economic disparity in
bicycle helmet use by children six years after the
introduction of legislation. Injury Prevention 2006:
12: pp 231-235.
Mahant S, Feigenbaum A: An infant with
developmental delay. Canadian Medical
Association Journal 2006: 175: pp 1369-1370.
O’Brodovich H, Beyene J, Tallett S, MacGregor D,
Rosenblum N: Performance of a career
development and compensation program at an
academic health science centre. Pediatrics 2007:
119: pp e791-e797.
Pope E, Krafchik BR, Macarthur C, Stempak D,
Stephens D, Weinstein M, Ho N, Baruchel S: Oral
versus high dose pulse corticosteroids in problematic hemangiomas of infancy: A randomized controlled
trial. Pediatrics 2007: 119: pp 1239-1247.
Pope E: TIMs for AD: What are the risks? The
Canadian Journal of CME 2007: 19: pp 60-62.
Schull MJ, Stukel TA, Vermeulen MJ, Guttmann A,
Zwarenstein M: Surge capacity associated with
restrictions on nonurgent hospital utilization and
expected admissions during an influenza
pandemic: Lessons from the Toronto Severe Acute
Respiratory Syndrome outbreak. Academic
Emergency Medicine 2006: 3: pp 1228-1231.
Schull MJ, Stukel TA, Vermeulen MJ, Zwarenstein
M, Alter DA, Manuel DG, Guttmann A, Laupacis A,
Schwartz B: Effect of widespread restrictions on
the use of hospital services during an outbreak of
severe acute respiratory syndrome. Canadian
Medical Association Journal 2007: 176:
pp 1827-1832.
Soon G, Saunders N, Ipp M, Sherman PM,
Macarthur C: Community-based case-control study
of childhood chronic abdominal pain: Role of
selected laboratory investigations. Journal of
Pediatric Gastroenterology and Nutrition 2007: 4:
pp 524-526.
Sutcliffe TL, Khambalia A, Westergard S, Jacobson
S, Peer M, Parkin PC: Iron depletion is associated
with daytime bottle feeding in the second and
third years of life. Archives of Pediatrics and
Adolescent Medicine 2006: 160: pp 1121-1125.
Sy K, Mahant S, Taback N, Vajsar J, Chait PG,
Friedman JN: Enterostomy tube placement in
children with spinal muscular atrophy Type 1.
Journal of Pediatrics 2006: 149: pp 837-839.
Weinstein M: Pediatric patient care: Part 1:
Pediatric lumps and bumps. Skin and Aging
2006: 14: pp 36-40.
ANNUAL REPORT 2006-07
BOOKS AND BOOK CHAPTERS
Al-Anazi A, Pope E: Dermatology. In: The Hospital
for Sick Children Handbook of Pediatric
Emergency Medicine (Lalani A, Schneeweiss S,
eds). Jones and Bartlett Publishers, Sudbury,
Massachusetts, 2007.
Au H: Paediatric section. In: The Toronto
Notes 2007 (Heng M, Greenwald JA, eds).
Toronto, 2007.
Baharestani MM, Pope E: Chronic wounds in
neonates and children. In: Chronic Wound
Care: A Clinical Source Book for Healthcare
Professionals, 4th Edition (Krasner DL,
Rodeheaver GT, Sibbald RG, eds). HMP
Communications, Malvern, PA, USA, 2007.
Beck CE: Your baby’s first few days: Your baby’s
months 2 to 6, introducing solid food. In: Canada’s
Baby Care Book: A Complete Guide from Birth
to 12 Months Old (Friedman JN, Saunders N,
eds). Robert Rose Inc., Toronto, 2007.
Birken CS: Your baby’s first few days: Your baby’s
first month, helping your baby sleep. In: Canada’s
Baby Care Book: A Complete Guide from Birth
to 12 Months Old (Friedman JN, Saunders N,
eds). Robert Rose Publishing, Inc., Toronto, 2007.
Feldman M: Bed-Wetting [Primary Nocturnal
Enuresis]. In: Sleep Disorders In Childhood (Weiss
S, ed). Robert Rose Publishing, Inc., Toronto,
2006.
Friedman JN: Paediatric section. In: The Toronto
Notes 2007, 23rd Edition (Heng M, Greenwald JA,
eds). Toronto, 2007.
Friedman JN, Saunders N: Canada’s Baby
Care Book. Robert Rose Publishing, Toronto,
Ontario, 2007.
Guttmann A, Lam K, Schultz S, Jaakkimainen LB:
Primary care for children. In: Primary Care in
Ontario ICES Atlas, Toronto, 2006.
Jaakkimainen L, Klein-Geltink JE, Guttmann A,
Barnsley J, Zagorski B, Kopp A, Saskin R, Leong
A, Wang L: Indicators of primary care based on
administrative data. In: Primary Care in Ontario
ICES Atlas, Toronto, 2006.
Maaten S, Guttmann A, Kopp A, Handa M,
Jaakkimainen L: Care of women during pregnancy
and childbirth. In: Primary Care in Ontario ICES
Atlas, Toronto, 2006.
Pope E, Krafchik B: Dermatologic disorders. In:
Residents Handbook of Neonatology (Kirpalani H,
Moore AM, Perlman M, eds). B.C. Decker Inc.,
Hamilton, Ontario. 2007.
Schultz S, Tepper J, Guttmann A, Jaakkimainen L:
Characteristics of primary care practice. In:
Primary Care in Ontario ICES Atlas, Toronto, 2006.
Dr. Elena Pope and clinic team
Cohen E, Uleryk E, Jasuja M, Parkin PC: An
absence of pediatric randomized controlled trials
in general medical journals, 1985-2004. Journal
of Clinical Epidemiology 2007: 60: pp 118-123.
FUNDING
A complex care clinic in a paediatric tertiary
academic health sciences centre. Cohen E, Mahant
S, Friedman JN, Adams S, Rosenbaum P. The
Hospital for Sick Children Paediatric Consultants
Partnership’s Grant ($10,000 2006-2007)
A prospective study on the age of onset,
incidence, geographic distribution and risk factors
associated with atopic dermatitis. Pope, E,
Krafchik BR, Pelletier J. Canadian Dermatology
Foundation ($35,000 1996-2007)
A randomized, prospective, double-blind placebocontrolled clinical study assessing the efficacy
of topical Tacrolimus 0.1% ointment and topical
Clobetasol propionate 0.05% ointment in the
treatment of vitiligo. Ho N, Krafchik BR, Pope E,
Greenberg S, Webster C, Weinstein M. Fujisawa
Canada Inc. ($62,425 2004-2007)
Access to care and health outcomes in Canadian
children. Guttmann A. Canadian Institutes of
Health Research New Investigator Salary Award
($250,000 2006-2011)
An office based intervention to improve media
use in preschool children: A randomized
controlled trial. Birken CS, Beck CE, McCrindle B,
Parkin PC. The Hospital for Sick Children
Paediatric Consultants Partnership’s Grant
($9,975 2006-2007)
Assessing Ontario’s Universal Influenza Immunization Program. Manuel D, Guttmann A, Kwong J,
Pourbohloul B, Moran MK. Canadian Institutes of
Health Research ($1,000,000 2007-2010)
Complementary medicine in Canadian paediatric
patients with atopic dermatitis: A cross sectional
survey. Weinstein M, Pope E, Redlick F. Canadian
Dermatology Foundation ($10,000 2006-2008)
Does the administration of intravenous ketorolac
alter the kinetics of intravenous morphine in
children with vaso-occlusive sickle cell crisis?
Scolnik D, Valani R, Friedman JN. The Hospital
for Sick Children Paediatric Consultants
Partnership’s Grant ($10,000 2004-2006)
Does the order in which vaccines are administered
affect pain response? A randomized, double-blind,
clinical trial of Pentacel vs. Prevnar. Ipp M, Taddio
A, Lear N, Goldbach M, Parkin PC. Sanofi Pasteur
($17,250 2006-2007)
Dr. Hosanna Au
Emergency department rapid intravenous
rehydration (RIVR) for paediatric gastroenteritis:
A randomized controlled trial. Freedman SB,
Parkin P, Willan AR, Schuh S. The Physicians’
Services Incorporated Foundation ($156,000
2005-2007)
Evaluation of the efficacy and safety of Imiquimod
5% topical cream in plaque morphea:
A prospective, multiple baseline, open label pilot
study. Pope E, Laxer R, Doria A, Babyn P.
3M Inc./Graceway Pharmaceuticals Canada
($29,500 2005-2008)
Genetic analysis of PHACE(S) Association. An
International registry based out of the University
of California, San Francisco. Frieden IJ, Pope E,
Siegel D. University of Southern California at San
Francisco ($20,000 2006-2008)
Guidelines for the ethical use of children in
medical education. Hilliard RI. The Hospital for
Sick Children Paediatric Consultants
Partnership’s Grant ($1,200 2006-2007)
Image guided gastrojejunostomy tube vs.
laparascopic nissen fundoplication neurologic
impaired children with gastroesophageal reflux
disease: A study examining health related quality
of life. Langer J, Mahant S, Connolly BC, Friedman
JN, Wales P, Unger W, Pastor A. Ontario Federation for Cerebral Palsy ($29,098 2007-2009)
Improving practice outcomes via electronic health
records. Stewart M, Manuel D, Guttmann A.
Ontario Ministry of Health and Long-Term Care
($499,700 2007-2008)
International registry for paediatric cutaneous Tcell lymphoma: a longitudinal, prospective,
observation study of cutaneous T-cell lymphoma
in the paediatric population. Pope E, Weinstein M,
Weitzman S, Taylor G. Canadian Dermatology
Foundation ($10,000 2004-2008)
International registry of paediatric cutaneous T-cell
lymphoma: a longitudinal, prospective, observation
study of cutaneous T-cell lymphoma in the paediatric
population. Pope E. University of Toronto Dean’s
Fund New Staff Grants ($10,000 2004-2009)
Isotonic versus hypotonic IV maintenance fluid in
children: A randomized controlled trial. Friedman
JN, Freedman S, Beck C, Geary D. The Hospital
for Sick Children Paediatric Consultants
Partnership’s Grant ($9,956 2007-2008)
Knowledge and attitudes of paediatric residents
towards disclosure of adverse events. Matlow A,
Coffey T, Tallett S. The Hospital for Sick Children
Paediatric Consultants Partnership’s Grant
($5,000 2007-2008)
Magnesium for Sickle Cell Trial (MAST). Goldman
R., Mounstephen W, Kirby M, Friedman JN.
The Physicians’ Services Incorporated Foundation
($163,846 2005-2007)
Modifiable risk factors for acute chest syndrome
in children with sickle cell disease admitted
to hospital with a painful crisis. Birken CS,
Khambalia A, Dekker A, Pastor A, Lee M,
Padavattan K, Parkin PC. The Hospital for Sick
Children Paediatric Consultants Partnership’s
Grant ($3,750 2005-2007)
Nutritional education and the prevention of iron
depletion in children 9 months to 2 years:
A randomized controlled trial. Parkin PC, Maguire
J, Khambalia A, Jacobson S, Peer M. Danone
Institute ($61,148 2006-2008)
Open label extension study to determine safety
of etanercept in paediatric subjects with plaque
psoriasis. Pope E, Weinstein M. Amgen Inc.
($43,000 2006-2008)
Palindromy at the NF1 locus as a risk factor for
NF1-associated malignancy. Lewis S, Parkin P.
SickKids Research Institute New Ideas Grant
Competition ($45,023 2006-2009)
Paediatric outcomes research. Parkin PC,
Macarthur C. SickKids Foundation ($1,000,000
2007-2012)
Paediatric surgeries in Ontario. Guttmann A,
Stukel T. Ontario Ministry of Health and LongTerm Care. ($160,000 2007)
PEWS translation project: From retrospective
algorithm to real-time bedside tool. Parshuram C,
Hutchison J, Parkin PC, Beyene J, Dryden-Palmer
K. HSFO Grant-in-Aid ($74,652 2006-2007)
Placebo-controlled multicentre study with
etanercept to determine safety and efficacy in
paediatric subjects with plaque psoriasis. Pope E,
Weinstein M. Amgen Inc. ($42,000 2005-2006)
Practices and beliefs of nurses and paediatricians
in level II nurseries toward newborn breastfeeding
supplementation methods. Feldman M, Tamim H.
York University Faculty of Arts Internal Research
Grant ($5,000 2006-2007)
Presentation, management and outcomes
evaluation of children with vascular tumours. Pope
E, Mahant S, Weinstein M, Blanchette V. The
Hospital for Sick Children Paediatric Consultants
Partnership’s Grant ($9,900 2006-2007)
Primary care practice characteristics and regional
physician supply: effects on access to primary
and specialty care for children in Ontario: A first
look. Guttmann A (PI), Stukel T, To T, Manuel D,
Glazier R, Dick P. The Physicians’ Services
Incorporated Foundation ($123,000 2006-2008)
The efficacy of Trimethoprim in wound healing of
patients with epidermolysis bullosa: A randomized,
double blinded, placebo controlled, cross-over
pilot study. Pope E, Lara-Corrales I, Weinstein M,
Parkin P, Sibbald G. dEBra Canada ($10,000
2006-2008)
TKT024EXT: An open-label extension of study
TKT024 evaluating the long-term safety and
clinical outcomes in MPS II patients receiving
Iduronate-2-Sulfatase enzyme replacement
therapy. Clarke JTR, Friedman J. Transkaryotic
Therapies Inc. ($111,497 2005-2007)
Treatment choices for children with typical acute
immune thrombocytopenic purpura: development
of a decision aid. Beck C, Birken CS, Blanchette
V, Boydell K, Llewellyn-Thomas H, Parkin PC.
Dean’s Fund New Staff Competition, Spring
2006, Faculty of Medicine, University of Toronto
($10,000 2006-2011)
What makes an excellent clinician in an academic
health science centre? Mahant S, Wadhwa A. The
Hospital for Sick Children Paediatric Consultants
Partnership’s Grant ($8,300 2006)
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
101
Respiratory Medicine
DIVISIONAL OVERVIEW
The Respiratory Medicine Program provides comprehensive care
for the full range of paediatric pulmonary diseases such as
asthma, cystic fibrosis, interstitial lung diseases, primary ciliary
dyskinesia and chronic respiratory insufficiency in infancy due to
prematurity and/or congenital malformations. We also provide
consultation support for the Hospital in all areas of paediatric
respiratory disease. We maintain an ongoing follow-up program for
children technologically dependent with chronic respiratory
insufficiency. The Sleep Laboratory (the only dedicated paediatric
sleep laboratory in Ontario) provides diagnostic services and
follow-up in care for children with sleep apnea, sleep related
respiratory insufficiency. It is affiliated with Division of Neurology
in caring for children with complex neuro-behavioural sleep
disorders. The Division also provides a flexible bronchoscopy
program in the diagnosis of anatomical abnormalities, infection in
the immunocompromised host and children with interstitial lung
disease. Over the last years we have broadened our diagnostic
spectrum of tests to assess diseases with airway inflammation
including test of nitric oxide in exhaled air. The addition of an
infant pulmonary function laboratory has broadened the potentials
for diagnostic tools to objectively assess lung disease in infants
and young children and is now open for the assessment of both
patients in the hospital and for outpatients. It is currently the only
laboratory in the country offering this service. We are currently in
the process to close the gap by developing a pulmonary function
test for preschool children as well.
Dr. Indra Narang in the sleep lab
As part of the Toronto Lung Transplantation Program the Division
provides pre- and post transplantation care for children with endstage lung disease. The lung transplant program continues to
be the largest paediatric lung transplant program in the country.
The training program has independent Royal College of Physicians
and Surgeons of Canada accreditation and is the largest training
program for paediatric respiratory medicine in the country. It
provides the full range of training that is required for Board
Certification in Pediatric Pulmonology in the United States. As well
as offering training to Royal College of Physicians and Surgeons of
Canada eligible candidates, it also trains physicians from abroad.
Dr. Indra Narang, a Paediatric Pulmonologist has joined our team
from Great Ormond Street in London after an interim training
period at the Children’s Hospital in Philadelphia and has taken
over the care of patients with sleep related respiratory disorders,
which also forms the focus of her future research. Dr. MacLusky,
who has been involved in many clinical activities over the last two
decades, has left our division to become the Head of Respiratory
Division Head
Dr. Felix Ratjen
Full-Time
Dr. Allan L. Coates
Dr. Sharon Dell
Dr. Hartmut Grasemann
Dr. Indra Narang
Dr. Hugh O’Brodovich
Dr. Melinda Solomon
Dr. Padmaja Subbarao
Dr. Neil B. Sweezey
Part-Time
Dr. Peter Bikangaga
Dr. James MacFarlane
Dr. Theo Moraes
Dr. Charlotte D’E. Miller
Adjunct Scientist
Dr. Hiran Selvadurai
Cross-Appointees
Dr. T. Douglas Bradley
Dr. Theodore Marras
Honorary
Dr. Gregory Downey
Dr. Dennis Gurwitz
Medicine at the Children’s Hospital in Ottawa. Dr. Hugh O’Brodovich,
who has served as the Chair of Paediatrics for 10 years and who
was on sabbatical this year, has accepted a position as Chair of
Pediatrics at the Children’s Hospital in Stanford. Members of the
Division are actively involved in an international program to develop
a new classification for interstitial lung diseases (Dr. Dell), a NIH
sponsored study on primary ciliary dyskinesia (Dr. Dell). Dr. Sharon
Dell, in collaboration with researchers from the University of
California in Berkeley, is leading a study entitled T-CHEQ or Toronto
Child Health Evaluation Questionnaire which is examining the
association between asthma and traffic-related air pollution
including parents of over 6,000 Grade 1 and 2 schools in Toronto.
Dr. Solomon has received an educational development grant from
the Centre of Faculty Development to study the cognitivebehavioural aspects of teaching communication. The division is
also involved in the planning of an AllerGen sponsored birth cohort
study to elucidate the factors important for the development of
asthma in early childhood (Dr. Subbarao).
In addition, the CF team is involved in a number of clinical studies
including a multi-centre study on azithromycin in Pseudomonas
negative CF patients that will be the first collaborative study funded
by the US CF foundation conducted in Canada and the US (Dr.
Ratjen), studies to elucidate the role of arginase and NO deficiency
in CF lung disease sponsored by CIHR and the Canadian CF
foundation (Dr. Grasemann) and a study on the role of aspergillus
infection in CF (Dr. Ratjen in collaboration with Dr. Shawn Aaron in
Ottawa) that received initial funding from both the Canadian CF
foundation and Physician Service Incorporated and which is planned
to involve multiple sites in Canada and Australia. The division is
also involved in developing new outcomes measures to assess
improvement in CF lung disease within the BREATHE program, a
study to develop CFTR corrector therapy the Canadian CF
Foundation (Dr. Ratjen). The division also continues to be involved
in the NIH Childhood Asthma Management Program Continuation
Study (Dr. Subbarao, Dr. Grasemann). Other studies are ongoing
and supported by research grants as well as generous support by
individuals such as the Irwin family.
The major research foci include clinical and epidemiological studies
in patients with asthma and cystic fibrosis, translational studies
on airway inflammation in cystic fibrosis, basic science studies on
molecular biology of electrolyte transport in the lung epithelium as
well as on novel genes in lung development, studies in aerosol
therapy and exercise physiology. For a more complete description
of our research interests, please visit our website.
Dr. Michael Hutcheon
Dr. Jacqueline Nemni
Dr. Elizabeth Tullis
Fellows
Dr. Dimas Mateos-Corral
Dr. Harutai Kamalaporn
Dr. Mustafa Osman
Subspecialty Residents
Dr. Suhail Al-Saleh
Dr. Reshma Amin
Dr. Rakesh Bhattacharjee
Dr. Tauyee Hsieh
Dr. Dhenuka
Radhakrishnan
Dr. Anwar Sallam
Administrative Staff
Tara Beattie
Jennifer Chay
Rea Magi
Victoria Snell
BГјscher R, Grasemann H: Disease modifying
genes in cystic fibrosis: Therapeutic option or oneway road? Naunyn Schmiedebergs Archives of
Pharmacology 2006: 374: pp 65-77.
Chan EY, Avcin T, Dell SD, Manson D, Cutz E,
Schneider R, Ratjen F: Massive hemoptysis in an
11-year-old girl with isolated pulmonary arteries.
Pediatric Pulmonology 2007: 42: pp 177-180.
Elias N, Rafii B, Otulakowski G, Cutz E and
O’Brodovich H: The role of α, ß, and γ-ENaC
subunits in distal lung epithelial fluid absorption
induced by pulmonary edema fluid. American
Journal of Physiology – Lung Cellular and
Molecular Physiology May 18, 2007 [Epub ahead
of print].
Gandhi SG, Rafii R, Harris M, Mahuran D, Chen
X-J, Bao H-F, Eaton D, Otulakowski G and
O’Brodovich H: Effect of cardiogenic edema fluid
on ion and fluid transport in the adult lung.
American Journal of Physiology – Lung Cellular
and Molecular Physiology June 8, 2007 [Epub
ahead of print].
Grasemann H, Schwiertz R, Grasemann C,
Vester U, RackГ© K, Ratjen F: Decreased systemic
bioavailability of L-arginine in cystic fibrosis
patients. Respiratory Research 2006: 7: p 87.
Grasemann H, Stehling F, Brunar H, Widmann R,
Laliberte T, Molina L, Döring G, Ratjen F: Safety
and efficacy of inhaled Moli1901 in cystic
fibrosis. Chest 2007: 131: pp 1461-1466.
Grasemann H, Kurtz F, Ratjen F: Inhaled L-arginine
improves exhaled nitric oxide and pulmonary
function in patients with cystic fibrosis. American
Journal of Respiratory and Critical Care Medicine
2006: 174: pp 208-212.
Henke M, Ratjen F: Mucolytics in cystic fibrosis.
Pediatric Respiratory Reviews 2007: 8: pp 24-29.
Katz S, Adatia I, Louca E, Leung K, Humpl T,
Reyes J, Coates AL: Nebulized therapies for
childhood pulmonary hypertension: An in vitro
model. Pediatric Pulmonology 2006: 41:
pp 666-673.
Kennedy MP, Omran H, Leigh MW, Dell SD,
Morgan L, Zariwala MA, Molina PL, Minnix SL,
Severin T, Ahrens P, Lange L, Noone PG, Knowles
MR: Congenital heart disease and other
heterotaxic defects in a large cohort of patients
with primary ciliary dyskinesia. Circulation 2007:
115: pp 2814-2821.
Lam W, Tjon J, Seto W, Dekker A, Wong C, Atenafu
E, Bitnun A, Waters V, Yau Y, Solomon M, Ratjen
F: Pharmacokinetic modelling of a once-daily
dosing regimen for intravenous tobramycin
in paediatric cystic fibrosis patients. Journal of
Antimicrobial Chemotherapy 2007: 59:
pp 1135-1140.
104
DEPARTMENT OF PAEDIATRICS
Leung K, Louca E, Munson K, Dutzar B, Anklesaria
P, Coates AL: Calculating expected lung deposition
of aerosolized administration of AAV vector in
human clinical studies. Journal of Genetics and
Medicine 2007: 9: pp 10-21.
Louca E, Leung K, Coates AL, Mitchell JP,
Nagel MW: Comparison of three valved holding
chambers for the delivery of fluticasone
propionate-HFA to an infant face model. Journal
of Aerosol Medicine 2006: 19: pp 160-167.
MacGregor, D, Tallett S, MacMillan S, Gerber R,
O’Brodovich H: Academic physician clinical and
education workload measurements using personal
digital assistant based software (T-ResВ®).
Pediatrics 2006: 118: pp e985-e991.
O’Brodovich H, Beyene J, Tallett S, MacGregor D,
Rosenblum N. Performance of a career
development and compensation program at an
academic health science center. Pediatrics 2007:
119: pp e791-e797.
O’Brodovich H: Fluid clearance from the lungs of
newborns, infants and children. Paediatric
Respiratory Review 2006: 7: pp S62-S64.
Otulakowski G, Duan W, O’Brodovich H: Oxygen
and dexamethasone modulate translation of aENaC in fetal lung epithelia via eIF4F. American
Journal of Respiratory and Cell Molecular
Bioliology June 7, 2007 [Epub ahead of print].
Otulakowski G, Rafii B, Harris M, O’Brodovich H:
Oxygen and glucocorticoids modulate translation
of the epithelial sodium channel a – subunit
mRNA in fetal distal lung epithelium. American
Journal of Respiratory and Cell Molecular Biology
2006: 34: pp 204-212.
Otulakowski, G, O’Brodovich H: Invited
Commentary: Thyroid hormone and Na+,K+ATPase: More than simple transcription. American
Journal of Physiology – Lung Cellular and
Molecular Physiology 2007: 292: pp L4-L5.
Radhakrishnan D, Corey M, Dell SD: Are patients
followed in a pediatric cystic fibrosis clinic able to
expectorate sputum? Archives of Pediatric
Adolescent Medicine 2007: 161: pp 603-606.
Ratjen F, Beier H, Grasemann H: Pharmacokinetics
of inhaled colistin in patients with cystic fibrosis:
authors’ response. Journal of Antimicrobial
Chemotherapy 2006: 58: p 223.
Ratjen F, Walter H, Haug M, Meisner C,
Grasemann H, Döring G: Diagnostic value of
serum antibodies in early Pseudomonas
aeruginosa infection in cystic fibrosis patients.
Pediatric Pulmonology 2007: 42: pp 249-255.
Ratjen F: Inhaled hypertonic saline produces
small increases in lung function in patients with
cystic fibrosis. Journal of Pediatrics 2006: 149:
p 142.
ANNUAL REPORT 2006-07
Ratjen F: Treatment of early P. aeruginosa
infection in patients with cystic fibrosis. Current
Opinion in Pulmonology Medicine 2006: 12:
pp 428-432.
Ratjen F: Diagnosing and managing infection
in CF. Paediatric Respiratory Review 2006: 7:
pp S151-S153.
Ratjen F: What’s new in CF airway inflammation:
An update. Paediatric Respiratory Review 2006:
7: pp S70-S72,
Schnabel D, Grasemann C, Staab D, Wolfmann H,
Ratjen F: A multicenter, randomized, double-blind,
placebo-controlled trial to evaluate the metabolic
and respiratory effects of growth hormone in
children with Cystic Fibrosis. Pediatrics 2007:
119: pp e1230-1238.
Schuh S, Dick P, Stephens D, Hartley M, Khaikin
S, Rodrigues L, Coates AL: High-dose inhaled
Fluticasone does not replace oral Prednisolone in
children with mild to moderate acute asthma.
Pediatrics 2006: 118: pp 644-650.
Scolnik D, Coates AL, Stephens D, Da Silva Z,
Lavine E, Schuh S: A randomized trial of
controlled delivery of high versus low humidity
versus mist therapy in croup. Journal of the
American Medical Association 2006: 295:
pp 1274-1280.
Starosta V, Ratjen F, Rietschel E, Paul K, Griese
M: Anti-inflammatory cytokines in cystic fibrosis
lung disease. European Respiratory Journal 2006:
28: pp 581-587.
Stehling F, Roll C, Ratjen F, Grasemann H: Nasal
nitric oxide to diagnose primary ciliary dyskinesia
in newborns. Archives of Disease in Childhood –
Fetal and Neonatal Edition 2006: 91: p F233.
Stocks J, Coates AL, Bush: Lung function in
infants and young children with chronic lung
disease of infancy: The next steps? Pediatric
Pulmonology 2007: 42: pp 3-9.
Subbarao P, Balkovec S, Solomon M, Ratjen F:
Safety and tolerability of hypertonic saline
inhalation in infants with Cystic Fibrosis. Pediatric
Pulmonology 2007: 42: pp 471-476.
Subbarao P, Duong M, Adelroth E, Otis J,
Obminiski G, Inman M, Pedersen S, O’Byrne PM:
Effect of ciclesonide dose and duration of therapy
on exercise-induced bronchoconstriction in
patients with asthma. Journal of Allergy and
Clinical Immunology 2006: 117: pp 1008-1013.
Subbarao P, Ratjen F: Beta2 agonists for asthma:
The pediatric perspective. Clinical Review in
Allergy and Immunology 2006: 31: pp 209-218.
Subbarao P, Balkovec S, Solomon M, Ratjen F:
Pilot study of safety and tolerability of inhaled
hypertonic saline in infants with cystic fibrosis.
Pediatric Pulmonology 2007: 42: pp 471-476.
Dr. Neil Sweezey and lab group
PUBLICATIONS
Sweezey N, Smith D, Corey M, Ellis L, Carpenter
S, Tullis E, Durie P, O’Brodovich H: Amilorideinsensitive nasal potential difference varies with
the menstrual cycle in cystic fibrosis. Pediatric
Pulmonology 2007: 42: pp 519-524.
Taylor L, Corey M, Matlow A, Sweezey NB, Ratjen,
F: Comparison of Throat swabs and
nasopharyngeal suction specimens in nonsputum-producing patients with cystic fibrosis.
Pediatric Pulmonology 2006; 41: pp 839-843.
Tschiedel E, Grasemann H, Ratjen F:
Mycobacterium chelonae in a CF patient with
anaplastic large cell lymphoma. Journal of Cystic
Fibrosis 2006: 5: pp 133-136.
Waters V, Ratjen F: Multi-drug resistant organisms
in cystic fibrosis: Management and infection
control issues. Expert Review of Antiinfective
Therapy 2006: 4: pp 807-819.
BOOKS AND BOOK CHAPTERS
Gjevre J, Coates AL, Jeanneret A, Kovesi T, Lands
L, Saiman L, Solomon M, Tullis E, Wilcox P:
Canadian Consensus Statement On Aerosolized
Antibiotic Use in Cystic Fibrosis. Toronto, The
Canadian Cystic Fibrosis Foundation, 2006.
Grasemann H: Disease modifier genes in CF. In:
European Respiratory Monograph (Webb AK,
Ratjen FA, eds). London, European Respiratory
Society Journals Ltd., 2006.
Grasemann H, Ratjen F. Fehlbildungen des
unteren respirationstrakts. In: Duale Reihe
Pädiatrie (Friedrich Carol Sitzmann, ed).
Stuttgart, Thieme, 2007.
Grasemann H, Ratjen F. Spezielle krankheitsbilder
des unteren respirationstrakts. In: Duale Reihe
Pädiatrie (Friedrich Carol Sitzmann, ed). 2007.
LemariГ© E, Diot P, Coates AL, Lerondel S,
Le Pape A, Grimbert D, Gagnadoux F, Urban T :
Autres indications et nouvelles approches
thérapeutiques. In: L’aérosolthérapie Par
NГ©bulisation. Paris, Editions Margaux Orange,
2006.
Ratjen F, Grasemann H. Leitsymptom husten.
In: Duale Reihe Pädiatrie (Friedrich Carol
Sitzmann, ed). 2007.
Ratjen F, Grasemann H. Leitsymptom akute
atemnot. In: Duale Reihe Pädiatrie (Friedrich Carol
Sitzmann, ed). 2007.
106
DEPARTMENT OF PAEDIATRICS
Ratjen F. Spezielle krankhetsbilder des oberen
Respirationstrakts. In: Duale Reihe Pädiatrie
(Sitzmann FC, ed). 2007.
Lung development. O’Brodovich H. Canadian
Institutes of Health Research ($140,265
2004-2009)
Webb AK, Ratjen, FA (eds): Cystic fibrosis. In:
European Respiratory Monograph, London,
European Respiratory Society Journals Ltd., 2006.
Multi-center, multi-national, randomized, placebocontrolled trial of azithromycin in participants with
Cystic Fibrosis, 6-18 years old, culture negative for
Pseudomonas aeruginosa, Ratjen F. Cystic
Fibrosis Foundation Therapeutics Inc. (salary
support US$36,546 2006-2007)
FUNDING
A multistage population-based study to determine
the association between traffic-related air
pollution and childhood asthma. S Dell, D Stieb,
N Gilbert, M Jerrett, D Miller, T To. Health Canada
($562,273 2005-2007)
Are exhaled nitric oxide levels different in
paediatric sickle cell disease patients with
asthma? A cross-sectional study. Grasemann H,
Kirby-Allen M, Subbarao P, Liberman L. The
Hospital for Sick Children Paediatric Consultants
Partnership’s Grant ($10,000 2006-2007)
CAMP-CS II: The Hospital for Sick Children Clinical
Centre for Study of a Childhood Asthma
Management Program – Continuation Study Part
II. Grasemann H, Solomon M, Subbarao P.
Johns Hopkins University Centre for Clinical Trials:
National Institutes of Health, National Heart,
Lung and Blood Institute ($631,133 2003-2007)
Characterization of factors and mechanisms
affecting physical activity, muscular function and
lung health in Cystic Fibrosis. Coates AL, Ratjen R.
Canadian Cystic Fibrosis Foundation ($180,000
2006-2008)
Diagnostic utility of induced sputum using
hypertonic saline to evaluate airway inflammation
and inflammation in CF. Ratjen F, Al-Saleh S,
Dell SD, Grasemann H. The Lynne & Arnold Irwin
Foundation ($30,000 2006-2007)
Equipment grant. Grasemann G. The Lynne &
Arnold Irwin Foundation ($10,000 2006)
Functional analyses of two novel, developmentally-regulated glucocorticoid responsive
genes in fetal lung. Kaplan F, Sweezey N.
Canadian Institutes of Health Research
($131,119/year 2004-2009)
Glucocorticoid receptor and glucocorticoidresponsive genes in developing lung. Sweezey N,
Kaplan F. Canadian Institutes of Health Research
($563,500 2004-2009)
How should nasal nitric oxide be measured to
screen for PCD in children? Dell S, Grasemann H,
Ratjen F. The Hopsital for Sick Children Paediatric
Consultants Partnership’s Grant ($10,000
2006-2007)
ANNUAL REPORT 2006-07
Mucociliary clearance consortium, rare diseases
center. Dell S (SickKids site), Knowles M (Primary
site: Chapel Hill). National Institute of Health
($40,000 2005-2007)
Ontario asthma database – Asthma plan of action
strategy. To T, Cicutto L, Dell S, Dick PT. The
Ontario Ministry of Health and Long-Term Care
($500,000 2003-2007)
Project #2.9 – Planning a Canadian longitudinal
birth cohort study of asthma and allergy in
childhood. Sears M, Subbarao P, Cyr M, Becker A,
O’Byrne P. AllerGen NCE Inc. ($240,000
2004-2007)
Project #FP-2005-10-development of objective
measurement of airway inflammation and lung
function in infants. Subbarao P, Sears M, Post M,
Palaniyar M. AllerGen NCE Inc. ($342,300
2004-2007)
Randomized, open labeled, cross over deposition
study of Tobramycin 100 Pari nebulized with
eFlowВ® versus TOBIВ® nebulized with Pari LC
PLUSВ® in subjects with CF. Coates AL, Ratjen F,
Charron M. Pari Gmb ($130,000 2006)
Role of arginine metabolism in allergic asthma.
Scott J, Grasemann H. Ontario Thoracic Society.
($43,650 2006-2007)
Training program in clinical nutrition. Pencharz P,
Anderson H, Coates A, Darling P, O’Connor D,
Archer M, Wolever T. Canadian Institutes of Health
Research ($1,590,000 2002-2008)
Translational regulation of perinatal lung
Na+ transport. Otulakowski G, O’Brodovich H.
Canadian Institutes of Health Research
($743,580 2004-2009)
T5602 New approach to augment clearance of
pulmonary edema. O’Brodovich H. Heart
and Stroke Foundation of Ontario ($270,832
2005-2008)
Rheumatology
DIVISIONAL OVERVIEW
The Division of Rheumatology provides comprehensive care for
children with rheumatic diseases. The ambulatory clinics have
approximately 5,000 patient visits per year at The Hospital for
Sick Children and Bloorview Kids Rehab sites and the outreach
clinic in Sudbury. In addition to the general rheumatology
clinics, there are unique multidisciplinary subspecialty clinics
for children with dermatomyositis, morphea, systemic JIA and
systemic lupus erythematosus. A new clinic for children with
central nervous system vasculitis has been initiated. The
division makes extensive use of the medical day care unit,
where children receive joint injections under anaesthesia,
therapeutic infusions or undergo investigations which
would otherwise require inpatient admission. An increasing
number of children have benefited from treatment with
biologic agents on the medical day care unit.
Research foci include the development of trial design for the study
of rare diseases, outcome, prognosis and treatment studies in
juvenile arthritis, SLE, neonatal lupus, scleroderma,
dermatomyositis and vasculitis. Basic research focuses on the
immunopathogenesis of Kawasaki disease using an animal model.
Dr. Susanne Benseler was appointed as a full-time faculty
member in the Division of Rheumatology. Dr. Benseler is a
clinician-investigator with a major research interest in central
nervous system vasculitis.
The Paediatric Rheumatology Training Program had an extremely
positive review by the Royal College of Physicians and Surgeons
Accreditation team and was recommended full approval for the
next six years.
The Division of Rheumatology has the largest paediatric
rheumatology fellowship training program in North America
and is fully accredited by the Royal College of Physicians
and Surgeons of Canada. This academic year, our fellows
originated from Czechoslovakia, Israel, Turkey, India and
Canada. Paediatric Rheumatology graduates have done
extremely well in obtaining academic placements across
Canada and around the world and trainees have been
productive in the research arena.
Division Head
Dr. Rayfel Schneider
Full-Time
Dr. Susanne Benseler
Dr. Brian Feldman
Dr. Ronald Laxer
Dr. Shirley Tse
Dr. Rae Yeung
Major Part-Time
Dr. Earl Silverman
Dr. Lynn Spiegel
Part-Time
Dr. Bonnie Cameron
Cross Appointees
Dr. Vivian Bykerk
Dr. Hans-Michael Dosch
Dr. Paul Fortin
Clinical Fellows
Dr. Yonatan Butbul
Dr. Serdar Cantez
Dr. Linda Hiraki
Dr. Roman Jurencak
Dr. Sathish Kumar
Dr. Heinrike Schmeling
Dr. Elizabeth Stringer
Administrative Staff
Sandra Bergeron
Shona Magee
Roseanne Richard
HONOURS AND AWARDS
Feldman B: Canada Research Chair in Childhood
Arthritis, Tier II, 2007.
Feldman B: Department of Paediatrics Research
Achievement Award, June 2007
Feldman B: Winner of the Arthritis Foundation
(Alabama Chapter) Outstanding Speaker Award
for Rheumatology on the Beach, 2007.
Silverman E: Advisor, Arthritis Panel, U.S. Food
and Drug Administration.
Tse S: Promoted to Program Director in the
Division of Rheumatology.
Yeung R: The Arthritis Society Investigator Award,
2007.
Stringer E: Tied for third place at the May 2007
Department of Paediatrics Annual Research Day
for her Oral Presentation: Predicting the disease
course of juvenile dermatomyositis – significance
of early and clinical laboratory features.
Stringer E: Winner of the Canadian Rheumatology
Association Paediatric Research Prize.
Stringer E: Runner up for the Department of
Paediatrics 2007 CanMeds Award.
Tyrrell P: IMS, PhD candidate at the University of
Toronto under the supervision of Dr. Earl Silverman,
was one of six finalists in the University of Toronto,
Institute of Medical Science Annual Laidlaw
Manuscript Competition. The title of his presentation was Atherosclerosis & lipid abnormalities in
paediatric systemic lupus erythematosus.
PUBLICATIONS
Avcin T, Schneider R, Tse S, Silverman ED:
Macrophage Activation Syndrome as the presenting
manifestation of rheumatic diseases in childhood.
Journal of Pediatrics 2006: 148: pp 683-686.
Avcin, T, Schneider R, Silverman ED, Singh-Grewal
D: Severe digital ischemia in a child with
Wegener’s granulomatosis. Scandinavian Journal
of Rheumatology 2007: 36: pp 78-80.
Aviv RI, Benseler SM, DeVeber G, Silverman ED,
Tyrrell PN, Tsang LM, Armstrong D: Angiography of
primary CNS vasculitis of childhood (cPACNS):
Conventional angiography (CA) versus magnetic
resonance angiography (MRA) at presentation.
American Journal of Neuroradiology 2007: 28:
pp 9-15.
Dr. Rayfel Schneider
Aviv RI, Benseler SM, Silverman ED, Tyrrell PN,
Deveber G, Tsang LM, Armstrong D: MR Imaging
and angiography of primary CNS vasculitis of
childhood. American Journal of Neuroradiology
2006: 27: pp 192-199.
Benseler SM, Silverman E, Aviv RI, Schneider R,
Armstrong D, Tyrrell PN, de Veber G: Primary
Central Nervous System Vasculitis in Children.
Arthritis and Rheumatism 2006: 54: pp 1291-1297.
Brown VE, Pilkington CA, Feldman BM, Davidson
JE: An international consensus survey of the
diagnostic criteria for juvenile dermatomyositis
(JDM). Journal of Rheumatology (Oxford) 2006:
45: pp 990-993.
Cabral DA, Laxer RM, Schrader J, Turvey S, Stevens
A, Yeung RS, Foster HE, Emery H, Prendiville J,
Tucker LB, Foeldvari I, Sherry DD, Klinkhoff AB,
Wallace CA, Houghton K: Old challenges and new
directions in pediatric rheumatology. Journal of
Rheumatology 2006: 33: pp 173-184.
Chagnon P, Schneider R, Hebert J, Fortin PR,
Provost S, Belisle C, Gingras M, Bolduc V,
Perreault C, Silverman E, Busque L: Identification
and characterization of an Xp22.33;Yp11.2
translocation causing a triplication of several
genes of the pseudoautosomal region 1 in an XX
male patient with severe Systemic Lupus
Erythematosus. Arthritis and Rheumatism 2006:
54: pp 1270-1278.
Chan EY, Avcin T, Dell S, Manson D, Cutz E,
Schneider R, Ratjen F: Massive haemoptysis in an
11-year-old girl with isolated pulmonary arteritis.
Pediatric Pulmonology 2007: 42: pp 177-180.
Doria A, Babyn PS, Feldman B: A Critical
appraisal of radiographic scoring systems for
assessment of Juvenile Idiopathic Arthritis.
Pediatric Radiology 2006: 36: pp 759-772.
Feldman BM, Pai M, Rivard GE, Israels S, Poon MC,
Demers C, Robinson S, Luke KH, Wu JK, Gill K,
Lillicrap D, Babyn PM: Tailored prophylaxis in severe
haemophilia A: Interim results from the first 5 years
of Canadian Haemophilia. Journal of Thrombosis
and Haemostasis 2006: 4: pp 1228-1236.
Gong GWK, McCrindle BW, Ching JC, Yeung RSM:
Arthritis presenting during the acute phase of
Kawasaki disease. Journal of Pediatrics 2006:
148: pp 800-805.
Hashkes PJ, Laxer RM: Updates on the medical
treatment of juvenile idiopathic arthritis. Current
Rheumatology Report 2006: 8: pp 450-458.
Hilliard P, Blanchette V, Feldman B, McLimont M,
Abad A: Haemophilia Joint Health Score Reliability
Study. Haemophilia Journal 2006: 12: pp 518-525.
Hui-Yuen JS, Duong TT, Yeung RSM: TNF-alpha is
necessary for induction of coronary artery
inflammation and aneurysm formation in an
animal model of Kawasaki disease. The Journal
of Immunology 2006: 176: pp 6294-6301.
Lang BA, Yeung RSM, Oen KG, Malleson PN,
Huber AM, Riley M, Ebbeson R, Ramsey SE, Laxer
RM, Silverman ED, McCrindle BW, Ratnapalan S,
Feldman BM: Corticosteroid treatment of
refractory Kawasaki disease. Journal of
Rheumatology 2006: 33: pp 803-809.
Laxer RM, Zulian F: Localized scleroderma. Current
Opinion in Rheumatology 2006: 18: pp 606-613.
Levine D, Akikusa J, Manson D, Silverman E,
Schneider R: Chest CT findings in pediatric
Wegener’s Granulomatosis. Pediatric
Rheumatology 2007: 37: pp 57-62.
Lovell DJ, Giannini EH, Reiff A, Jones OY,
Schneider R, Olson JC, Stein LD, Gedalia A,
Ilowite NT, Wallace CA, Lange M, Finck BK, Burge
DJ; for the Pediatric Rheumatology Collaborative
Study Group: Long-term efficacy and safety of
etanercept in children with polyarticular-course
juvenile rheumatoid arthritisArthritis and
Rheumatism 2006: 54: pp 1987-1994.
Matlow A, Stevens P, Harrison C, Laxer RM:
Disclosure of medical errors. Pediatric Clinics of
North America 2006: 53: pp 1091-1104.
Nathan PC, Tomlinson G, Dupuis LL., Greenberg
ML., Ota S, Bartels U, Feldman BM: A pilot study
of ondansetron plus metopimazine vs.
ondansetron monotherapy in children receiving
highly emetogenic chemotherapy: A Bayesian
randomized serial N-of-1 trials design. Supportive
Care in Cancer 2006: 14: pp 268-276.
Newburger JW, Sleeper LA, McCrindle BW, Minich
LL, Gersony W, Vetter VL, Atz AM, Li JS, Takahashi
M, Baker AL, Colan SD, Mitchell PD, Klein GL,
Sundel RP; Pediatric Heart Network Investigators.
Randomized trial of pulsed corticosteroid therapy
for primary treatment of Kawasaki disease.
New England Journal of Medicine 2007: 356:
pp 663-675.
Ota S, McLimont M, Carcao M, Blanchette V,
Graham N, Paradis E, Feldman BM: Definitions
for haemophilia prophylaxis and its outcomes:
The Canadian Consensus Study. Haemophilia
2007: 13: pp 12-20.
Pope E, Janson A, Khambalia A, Feldman BM:
Childhood acquired lipodystrophy: A retrospective
study. Journal of the American Academy of
Dermatology 2006: 55: pp 947-950.
Sarkissian T, Beyene J, Feldman B, Adeli K,
Silverman E: The complex nature of the interaction
between disease activity and therapy on the lipid
profile in patients with pediatric Systemic Lupus
Erythematosus. Arthritis and Rheumatism 2006:
54: pp 1283-1290.
Johnson SR, Laxer RM: Classification in systemic
sclerosis. Editorial. Journal of Rheumatology
2006: 33: pp 840-841.
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
109
Saurenmann RK, Levin AV, Feldman BM, Rose JB,
Laxer RM, Schneider R, Silverman ED: Prevalence,
risk factors, and outcome of uveitis in Juvenile
Idiopathic Arthritis. Arthritis and Rheumatism
2007: 56: pp 647-657.
Saurenmann RK, Levin AV, Rose JB, Parker S,
Rabinovitch T, Tyrrell PN, Feldman BM, Laxer RM,
Schneider R, Silverman, ED: Tumour necrosis
factor alpha inhibitors in the treatment of
childhood uveitis. Rheumatology (Oxford) 2006:
45: pp 982-989.
Saurenmann T, Schneider R, Silverman ED, Laxer
RM, Levin AV: Risk of new-onset uveitis in patients
with Juvenile Idiopathic Arthritis treated with
anti-TNF agents. Journal of Pediatrics 2006: 149:
pp 833-836.
Sharieff W, Zlotkin S, Tondeur M, Feldman B and
Tomlinson G: Physiologic mechanisms can predict
hematologic responses to iron supplements in
growing children: A computer simulation model.
The American Journal of Clinical Nutrition 2006:
83: pp 681-687.
Silverman ED, Strand V: Leflunomide in Juvenile
Idiopathic Arthritis. Future Medicine 2006: 1:
pp 673-682.
Silverman ED: Pediatric Systemic Lupus
Erythematosus. Future Medicine 2007: 2:
pp 23-50.
Singh-Grewal D, Schneider R, Bayer N, Feldman
BM: Predictors of disease course and remission
in systemic-onset juvenile Idiopathic arthritis:
Significance of early clinical and laboratory
features. Arthritis and Rheumatism 2006: 54:
pp 1595-1601.
Singh-Grewal D, Stephens S, Cameron B, Laxer
RM, Le Blanc C, Schneider R, SchneidermanWalker J, Selvadurai H, Silverman E, Spiegel L,
Tse S, Wright V, Feldman BM: Physical activity and
exercise in kids: The effects of vigorous exercise
training on motor function and functional fitness
in children with arthritis. Arthritis and Rheumatism
2006: 54: p S686.
Singh-Grewal D, Wright V, Bar-Or O, Feldman BM:
Pilot study of fitness training and exercise testing
in polyarticular childhood arthritis. Arthritis and
Rheumatism 2006: 55: pp 364-372.
110
DEPARTMENT OF PAEDIATRICS
Spence D, Hornberger LK, Hamilton RM,
Silverman ED: Increased risk of complete
congenital heart block in infants born to women
with hypothyroidism and anti-Ro and/or anti-La
antibodies. Journal of Rheumatology 2006: 33:
pp 167-170.
Stevens P, Matlow A, Laxer RM: Blueprint for
patient safety. Pediatric Clinics of North America
2006: 53: pp 1253-1267.
Stinson J, Petroz G, Tait G, Feldman B, Steiner D,
McGrath PJ, Stevens BJ: e-Ouch: Usability testing
of an electronic chronic pain diary for adolescents
with arthritis. Clinical Journal of Pain 2006: 22:
pp 295-305.
Sung L, Feldman BM: N-of-1 trials: innovative
methods to evaluate complementary and
alternative medicines in pediatric cancer. Journal
of Hematology Oncology 2006: 28: pp 263-266.
Sung L, Tomlinson GA, Greenberg ML, Koren G,
Judd P, Ota S, Feldman BM: Validation of the oral
mucositis assessment scale in pediatric cancer.
Pediatric Blood Cancer 2007: 49: pp 149-153.
Tse SML, Laxer RM, Babyn P, and Doria A:
Radiologic improvement of enthesitis related
arthritis following anti-tumor necrosis factor alpha
blockade with Etanercept. Journal of
Rheumatology 2006: 33: pp 1186-1188.
Tse SML, Laxer RM: Approach to acute limb
pain in childhood. Pediatrics in Review 2006: 27:
pp 170-179.
Wylie J, Campbell C, Pope J, Akikusa J, Laxer RM,
Nicolle D: Convergence paralysis as a
manifestation of polyarteritis nodosa. Canadian
Journal of Neurological Science 2006: 33:
pp 423-425.
Yeung RSM: Clinical Phenotype and Coronary
Outcome in Kawasaki Disease. The Lancet 2007:
369: pp 85-88.
Yeung RSM: Lessons learned from an
animal model of Kawasaki disease. Clinical and
Experimental Rheumatology 2007: 25:
pp S69-S71.
Zulian F, Athreya BH, Laxer R, Nelson AM, Feitosa
de Oliveira SK, Punaro MG, Cuttica R, Higgins GC,
Van Suijlekom-Smit LW, Moore TL, Lindsley C,
Garcia-Consuegra J, Esteves Hilario MO, Lepore L,
Silva CA, Machado C, Garay SM, Uziel Y, Martini
G, Foeldvari I, Peserico A, Woo P, Harper J:
Juvenile localized scleroderma: clinical and
epidemiological features in 750 children: An
international study. Rheumatology (Oxford) 2006:
45: pp 614-620.
ANNUAL REPORT 2006-07
Zulian F, Woo P, Athreya BH, Laxer RM, Medsger
TA Jr, Lehman TJ, Cerinic MM, Martini G, Ravelli
A, Russo R, Cuttica R, de Oliveira SK, Denton CP,
Cozzi F, Foeldvari I, Ruperto N: The Pediatric
Rheumatology European Society/American
College of Rheumatology/European League
against Rheumatism provisional classification
criteria for juvenile systemic sclerosis. Arthritis
Care & Research 2007: 57: pp 203-212.
BOOKS AND BOOK CHAPTERS
Feldman BM: Clinical trials in JIA. In: Arthritis in
Children and Adolescents. Juvenile Idiopathic
Arthritis (Szer I, Kimura Y, Malleson P, Southwood
T, eds). Oxford University Press, London, 2006.
Matlow A, Laxer RM, Guest Editors: Pediatric
Clinics of North America. Elsevier, Inc.,
Philadelphia, 2006.
Tse SML: You, your child and arthritis (Tse SML,
ed). The Arthritis Society, Toronto, 2006.
Yeung RSM, Ohashi P, Saunders MF, Mak TW: T
Cell development in primary immunodeficiency
diseases, a molecular and genetic approach. In:
Primary Immunodeficiency Disease: A Molecular
and Genetic Approach-Second Edition (Ochs HD,
Smith CIE, Puck J, eds). Oxford University Press,
New York, 2006.
FUNDING
1000 Canadian Faces of Lupus. Peschken C,
Pope J, Cooper GS, Silverman ED. The Arthritis
Society ($381,000 2004-2007)
A conceptual framework for outcome
measurement in children: Consequences for
health economic evaluation and decision-making.
Ungar W, Marshall DA, Willan AR, Wright JG,
Feldman BM. Canadian Institutes of Health
Research ($224,726 2003-2006)
Biologically-based outcome predictors in juvenile
idiopathic arthritis. Rosenberg A, Baxter-Jones AD,
Gordon J, Muhajarine N, Oen K, Pahwa P, Scherer
S, Turvey S, von Baever C, Whiting SJ, Yeung RSM,
Bernatsky S, Duffy C, Silverman ED. Canadian
Institutes of Health Research/Canadian Arthritis
Network ($1,500,000 2006-2011)
Childhood Arthritis and Rheumatology Research
Alliance. Sandborg C, Brewer E, Feldman B,
Hirsch R, Ilowite N, Jung L, Lovel D, Malleson P,
Mellins E, O’Neil K, Schanberg L, Wallace C.
Arthritis Foundation ($525,000 2004-2007)
Canada Research Chair Tier II. Feldman BM.
Canadian Institutes of Health Research
($500,000 2002-2007)
Dr. Susanne Benseler and the Vasculitis team
Sarkissian T, Beyenne J, Feldman B, McCrindle B,
Silverman ED: Longitudinal examination of lipid
profiles in pediatric Systemic Lupus
Erythematosus. Arthritis and Rheumatism 2007:
56: pp 631-638.
Determinants of risk and outcome in inflammatory
arthritis. Siminovitch K, Bernatsky S, Bombardier
C, Briollais L, MacPherson A, Oen K, Yeung RSM.
Canadian Institutes of Health Research
($2,000,000 2007-2012)
Development of a feasible tool to measure oral
mucositis in children with cancer. Sung L, Judd P,
Tomlinson D, Doyle J, Hendershot E, Maloney AM,
Feldman B. Paediatric Oncology Group of Ontario
($13,334 2007-2008)
Feasibility and impact of Qigong as compared to
aerobic exercise in the treatment of childhood
chronic musculoskeletal pain: A pilot randomized
controlled trial. Tse SML, Feldman BM (Co-PIs),
Fairbairn J, O’Brien C, Bar-Or O, SchneidermanWalker J, Singh-Grewal D, Stephens S, Stinson J,
Tyrell P, Whitney K, Wright V, Cameron B,
Lefebvre A, Laxer R, Schneider R, Silverman E,
Spiegel L (Co-Investigators), Wu H, Bustamante K
(Collaborators). SickKids Foundation
Complementary and Alternative Health Care
and Paediatrics Research Grant ($128,223
2005-2007)
Kawasaki disease: On our way to unraveling the
pathogenesis. Yeung RSM. Canadian Institutes of
Health Research ($318,873 2005-2008)
Moderate term musculoskeletal outcomes with
escalating dose: The Canadian Haemophilia
prophylaxis follow-up study (CHPS-2). Feldman
BM, Blanchette V, Babyn P, Hedden D. Bayer Inc.
Research Fund ($585,077 2003-2006)
New onset juvenile idiopathic arthritis:
A Canadian multi-centre collaborative outcomes
study. Duffy C, Oen K, Tucker L, Yeung RSM,
Feldman B, Feldman D, Young N. Canadian
Institutes of Health Research ($998,000
2004-2009)
112
DEPARTMENT OF PAEDIATRICS
Pain in Child Health (PICH: An innovative,
transdisciplinary, cross-Canada, research training
consortium. McGrath P, Craig K, von Baeyer C,
Stevens B, Johnston C, Finley A (Co-PIs),
Schellinck H, Unruh A, Kenny N, Camfield C,
Harmon K, Frager G, Rathwell T, Howlett A, Otley T,
Connolly J, Feldman BM, Langer J, Taddio A,
Baruchel S, Brown S, Gibbins S, Salter M,
Hetherington R, Grunau R, Oberlander T,
Chambers C, Dube L, Ohisson A, Murray M, Barr
R, Koren G (Co-Investigators). Canadian Institutes
of Health Research Training Grant ($300,000
2002-2008)
Research to improve outcomes for inflammatory
arthritis. Inman R, Gladman D, Maksymowych W,
Rahman P (Co-PIs), Davis A, Tsui F, Greenwood C,
Badley E, Scherer S, Reeve J, Cook R (Project CoInvestigators), Boonen A, Choquette D, Colbert R,
Frank J, Ghahary A, Gignac M, Husted J,
Keen K, Lambert R, Laxer R, Marra C, Mosher D,
Mulholland K, Nair B, Poole R, Richards C,
Salanen D, Shojania K, Thomson G, Tse S
(Collaborators). The Arthritis Society, National
Research Initiative (NRI) ($2,500,000
2005-2010)
Rituximab Therapy in Refractory Adult and Juvenile
IIM. Oddis CV, Reed AM, Pestronk A, Rider L,
Miller F, Eisenberg R, Feldman BM, Ytterberg S,
Levine T. National Institutes of Health
($7,732,309 2004-2009)
Superantigens in autoimmunity. Yeung RSM.
The Arthritis Society ($294,474 2003-2006)
Superantigens in autoimmunity. Yeung RSM.
Canadian Institutes of Health Research
($172,553 2006-2008)
The effects of vigorous exercise training on motor
function and functional fitness in Juvenile Arthritis.
Feldman B, Bar-Or O, Cameron BJ, Laxer RM,
Leblanc CMA, Schneider R, Schneiderman-Walker
JE, Selvadurai H, Silverman ED, Singh-Grewal D,
Spiegel L, Wright V. Canadian Institutes of Health
Research ($74,926 2005-2006)
ANNUAL REPORT 2006-07
The role of chronic inflammation and Systemic
Lupus Erythematosus-related factors in the
development of premature atherosclerosis in
paediatric SLE. Silverman ED, Bargman J, Bradley
T, Beyene J. The Heart and Stroke Foundation of
Canada ($275,000 2006-2009)
The role of traditional and non-traditional risks in
the development of atherosclerosis in paediatric
SLE. Silverman ED, McCrindle B, Adeli K,
Bargman J. The Heart and Stroke Foundation of
Canada ($271,854 2003-2006)
Towards a better understanding of Kawasaki
disease. Yeung RSM. The Heart and Stroke
Foundation of Canada ($160,565 2006-2008)
Towards guidelines for use of corticosteroids in
children with Lupus. Brunner H, Silverman ED.
National Institutes of Health ($150,000
2003-2006)
Towards understanding the mechanism of
congenital heart block. Hamilton RH, Gross G,
Silverman ED. Canadian Institutes of Health
Research ($197,000 2006-2009)
Validation of a new paediatric scoring system
from the IPSG: Validity reliability of the combined
HJHS. Feldman B, McHugh FS, Bergstrom B-M,
Zourikian N, Hilliard P, Van der Net J, Engelbert
RHH, Petrini P, Manco-Johnson M, Van
den Berg HM, Rivard GE, Blanchette VS. Bayer
HealthCare LLC ($246,039 2005-2006)
Validation of accelerometry as a measure of
physical activity and inactivity in children with
chronic disease. Feldman B, Stephens S, Takken
T, Wright V, Tramblay M, Beyenne J, Biggar W,
Esliger D, Longmuir P, McCrindle B,
Schneiderman-Walker J, Van Der Net J. Canadian
Institutes of Health Research – Institute of
Musculoskeletal Health and Arthritis (IMHA)
($64,985 2007-2008)
Bloorview Kids Rehab
DIVISIONAL OVERVIEW
BLOORVIEW INTERPROFESSIONAL GRAND ROUNDS
In November 2006, the inpatient Bloorview site relocated to
our new facility to complete the final phase of our move.
Inpatients, outpatients, clients and staff are all enjoying our
state-of-the-art facility, which sets standards for universal
accessibility. As a provincial facility, we see almost 7,000 children
and youth on an outpatient basis and we have over 650 patient
admissions each year.
• Introduced in January 2007 and occurring monthly
to bring leaders in their respective fields to Bloorview
Bloorview Kids Rehab offers both inpatient and outpatient
developmental and rehabilitation services to the children and
families of Greater Toronto and provides tertiary services in
paediatric rehabilitation to the Province of Ontario.
• Evidence-based practice, key patient safety and interprofessional
initiatives are a few examples
MEDICAL SERVICES STAFFING
Bloorview Kids Rehab
• Medical staff plus active consulting staff
9.5 FTEs
• Subspecialists
17
Department of Pharmacy
• Pharmacists
2.0 FTEs
Through the support of the Bloorview Kids Foundation, which funds
three positions, and Surrey Place Centre, which funds one position,
we continue to provide the largest Royal College accredited training
program for developmental paediatrics in the country.
• Pharmacy Assistant
1.0 FTE
The Bloorview Research Institute continues to grow under the
leadership of Dr. Colin Macarthur, Vice-President, Research.
• Chief of Dentistry and Manager
All of our medical staff members have appointments in the
Department of Paediatrics at the University of Toronto.
MEDICAL EDUCATION 2006
Our medical staff members lecture at the undergraduate level and
throughout the year to paediatric, neurology and physiatry
residents. Dr. Milo-Manson coordinates the developmental seminar
for second year medical students at the University of Toronto.
Paediatric R4
30 days
Neonatology
150 days
Neurology
180 days
Psychiatry
20 days
Dr. Anne Kawamura is our new paediatric resident rotation
coordinator.
Department of Dental Services
• Dr. Rob Carmichael appointed new Chief of Dental
Services, June 1, 2007
• Part-time staff
Paediatric RII
PM&R
Medical students
8
440 days
120 days
200 days
HIGHLIGHTS
Developmental paediatric subspecialty residents
1490 days
• Dr. Darcy Fehlings appointed Division Head of Developmental
Paediatrics, University of Toronto
Total
2630 days
• Second Roszell Developmental Paediatrics Research Day,
February 23, 2007
• Successful Royal College accreditation April 2007
Chief of Medical Staff
Dr. Golda Milo-Manson
Faculty
Dr. Doug Biggar
Dr. Elizabeth Jimenez
Division Head,
Dr. Tara Kennedy
Developmental Paediatrics,
Dr. Tamarah
University of Toronto
Kagan-Kushnir
Dr. Darcy Fehlings
Dr. Anne Kawamura
Dr. Tara Kennedy
Dr. Jeff Kobayashi
Dr. Gilbert Miller
Dr. Peter Rumney
Dr. Jonathan Tolkin
Developmental
Subspecialty Residents
Dr. Angela Orsino
Dr. Jonathan Ponesse
Dr. Kassia Johnson
Dr. Lyn Sonnenberg
PUBLICATONS
Biggar WD, Harris VA., Eliasoph L, Alman B: Longterm benefits of deflazacort treatment for boys with
Duchenne Muscular Dystrophy in their second decade.
Neuromuscular Disorders 2006: 16 pp 249-255.
Thomas-Stonell N, Johnson P, Rumney P, Wright V,
Oddson B: An evaluation of the responsiveness of a
comprehensive set of outcome measures for
children and adolescents with traumatic brain injury.
Pediatric Rehabilitation 2006: 9: pp 14-23.
Biggar W: Duchenne Muscular Dystrophy. Paediatrics Vajsar J, Zhang W, Dobyns WB, Biggar WD, Holden
KR, Hawkins C, Ray P, Olney AH, Burson CM,
in Review 2006: 27: pp 83-87.
Srivastava AK, Schachter H: Carriers and patients with
Georgiades S, Szatmari P, Zwaigenbaum L, Duku E,
muscle-eye-brain disease can be rapidly diagnosed
Bryson S, Roberts W, Goldberg J, Mahoney W:
by enzymatic analysis of fibroblasts and lymphoblasts.
The structure of the autism symptom phenotype:
Neuromuscular Disorders 2006: 16: pp 132-136.
A proposed multidimensional model. Journal
BOOKS AND BOOK CHAPTERS
of the American Academy of Child and Adolescent
Lingard LA, Kennedy TJT: Qualitative research in
Psychiatry 2007: 42: pp 188-196.
medical education. In: Understanding Medical
Ickowicz A, Feng Y, Wigg K, Quist J, Pathare T,
Education (Swanwick T, ed). Edinburgh, Association
Roberts W, Malone M, Schachar R, Tannock R,
for the Study of Medical Education, 2007.
Kennedy JL, Barr CL: Serotonin receptor HTR1B –
Gene polymorphisms in attention deficit hyperactivity Better Sleep for your Baby and Child: A Parent’s
Step-by-step Guide to Healthy Sleep Habits
disorder Neuropsychiatric Genetics 2007: 144B:
(Feldman M, Macfarlane J, Weiss S, MacLusky IB,
pp 121-125.
Milo-Manson G, eds). Robert Rose Publishers
Loh A, Soman T, Brian J, Bryson SE, Roberts W,
Toronto, 2006.
Szatmari P, Smith I, Zwaigenbaum L: Stereotyped
FUNDING
motor behaviours associated with autism in
A fine balance: Patient safety and trainee education
high-risk infants: A pilot videotape analysis of a
on clinical teaching teams. Kennedy T, Regehr G,
sibling sample. Journal of Autism and
Baker GR, Lingard LA. Canadian Institutes of Health
Developmental Disabilities 2007: 37: pp 25-36.
Research ($230,316 2004-2007)
Kawamura A, Campbell K, Lam-Damji S, Fehlings:
Autism spectrum disorders: Pathways to better
A randomized controlled trial comparing botulinum
outcomes. Szatmari P, Bryson SE, Fombonne E,
toxin A dosage in the upper extremity of children
Zwaigenbaum L, Smith I, Waddell C, Vaillancourt T,
with spasticity. Developmental Medicine & Child
Mirenda P, Roberts W, Volden J. Canadian Institutes
Neurology 2007: 49: pp 331-337.
of Health Research ($2,125,415 2004-2009)
Kennedy T, Lingard L: Making sense of Grounded
Theory. Medical Education 2006: 40: pp 101-108.
Loh A, Soman T, Brian J, Bryson SE, Roberts W,
Szatmari P, Smith I, Zwaigenbaum L: Stereotyped
motor behaviours associated with autism in
high-risk infants: A pilot videotape analysis of a
sibling sample. Journal of Autism and
Developmental Disabilities 2007: 37: pp 25-36.
Narayanan U, Fehlings D, Weir S, Kiran S, Campbell
K: Initial development and validation of the caregiver
priorities and child health index of life with
disabilities (CPCHILD). Developmental Medicine
and Child Neurology 2006: 48: pp 804-812.
Oddson B, Rumney P, Johnson P, Thomas-Stonell N:
Clinical use of the Mayo-Portland Adaptability
Inventory in rehabilitation after acquired brain injury.
Developmental Medicine and Child Neurology 2006:
48: pp 918-922.
Sanger T, Chen D, Delgado M, Gaebler-Spira D,
Hallett M, Mink J, and the Taskforce on Childhood
Motor Disorders, D. Fehlings (member): Definition
and classification of negative motor signs in
childhood, Paediatrics 2006: 118: pp 2159-2167.
Scherer SW, Szatmari P, Roberts W (The Autism
Genome Project Consortium): Mapping autism risk
loci using genetic linkage and chromosomal rearrangements. Nature Genetics 2007: 39: pp 319-328.
114
DEPARTMENT OF PAEDIATRICS
Books for siblings of children with autism: Children’s
assessments. Johnson K, McKeever P, Kawamura A.
Bloorview Research Institute Seed Grant ($5,500
2007-2008)
Evaluation with a message: Interprofessional
assessment of professionalism. Kennedy TJT, MiloManson G, Lingard LA. Medical Education Grant,
Royal College of Physicians and Surgeons of
Canada ($11,124.95 2006)
Evaluation of the reliability, validity and
responsiveness of the kinematic dystonia measure
in children with upper extremity dystonia. Kawamura
A, Fehlings D. Bloorview Research Institute Seed
Grant ($16,652 2007-2008)
Genetic epidemiology of autism: Family and
molecular studies. Szatmari P, Bryson S, Goldberg J,
Patterson A, Mahoney W, Merette C, Roberts W,
Zwaigenbaum L, Scherer S. Canadian Institutes of
Health Research ($725,000 2003-2008)
Evaluating outcomes associated with
multidisciplinary care for children with cerebral palsy
using clinical practice improvement methodology.
Damiano D, Chambers H, Revivo G, Brunstrom J,
Horn S, Gassaway J, Krach L, Gormley M, Novacheck
T, Matthews D, Chang F, Stevenson R, Abel M,
McLaughlin J, Bjornson K, Rathjen K, Delgado M,
Dabrowski E, Gaebler-Spira D, Dias L, Narayanan U,
Fehlings D, Graham K, Koman A. American Academy
for Cerebral Palsy and Developmental Medicine
($25,000 2006)
ANNUAL REPORT 2006-07
Functional outcomes following orthopaedic surgery
based on gait laboratory versus observational gait
analysis in ambulatory children with cerebral palsy:
A pilot randomized controlled trial. Narayanan U,
Fehlings D. Bloorview Research Institute ($25,015
2006-2007)
Functional outcomes following orthopaedic surgery
based on gait laboratory versus observational gait
analysis in ambulatory children with cerebral
palsy: A randomized controlled trial. Narayanan U,
Fehlings D. Pediatric Orthopaedic Society of North
America (29,820 2006)
Identifying early markers of autism: A prospective
study of infant siblings. Zwaigenbaum L, Roberts SW,
Smith I, Szatmari P, Bryson S. Canadian Institutes of
Health Research ($331,650 2003-2006)
Longitudinal study of the relationship between
impairment, activity limitation, participation
and quality of life in persons with Duchenne
muscular dystrophy – five-year study. Biggar D.
CINRG, Washington DC (reimbursed $200/
patient 2006-2011)
Self-perception, behavioural attributions and
perceptions of social relationships of adolescents
with ADHD and LD. Roberts W, Weiner J, Malone M.
Social Services & Humanities Research Council of
Canada ($143,877 2005-2008)
Training program in autism research. Fombonne E,
Paterson A, Scherer S, Roberts W, Smith I, Moore C.
Canadian Institutes of Health Research/National
Alliance for Autism Research/Fonds de la Recherche
en Sante du Quebec ($1,440,000 2003-2009)
The development of a virtual reality therapy homebased system to improve hand usage and function
in children with hemiplegia. Chau T, Fehlings D,
Lam-Damji S, Li W. Bloorview Research Institute
Seed Grant ($24,972 2007-2008)
The experience of hope in the psychosocial
adaptation of parents of a child with DMD. Tomiak
E, Biggar D. CHEO Research Institute ($10,000
2007-2008)
The development and evaluation of the HAT-D:
A discriminative tool differentiating types of
hypertonia in children. Jethwa A, Fehlings D.
Bloorview Research Institute ($9,600 2006-2007)
Validation of accelerometry as a measure of physical
activity and inactivity in children with chronic
disease. Feldman B, Biggar D. Canadian Institutes
of Health Research/Institute of Musculoskeletal
Health and Arthritis ($64,985 2007-2009)
Western Canada standards of care Initiative for
Duchenne muscular dystrophy. Mah J, Moore M,
Biggar D. CINRG International Grant Award,
University of Calgary ($20,000 2007-2008)
Paediatric Academic Multi-Organ
Transplant Program (PAMOT)
DIVISIONAL OVERVIEW
As a nationally and internationally recognized transplant program,
PAMOT is focused on the delivery of cutting-edge and state-of-theart family-centered care for patients. Excellence in clinical care is
enhanced by an active multi-specialty educational program, a
fellowship training program for emerging transplant physicians,
and advancing knowledge in the field of transplantation by
promoting and encouraging fundamental, translational and patientbased research activities.
PAMOT is one of the largest paediatric solid organ transplant
programs in North America, with well over 1000 children in receipt
of a solid organ transplant at this hospital. This past year has
continued to be a busy clinical year for all the organ transplant
groups. On May 18, 2007, we celebrated the opening of the 6A
Liam’s Light Step Down Unit; a project launched by the Liam’s
Light Charity in conjunction with SickKids Foundation. We also
celebrated the 20th year of liver transplantation at the hospital,
with a well attended multidisciplinary event at the Toronto Metro
Zoo in September 2006.
The training of a cadre of fellows who have been successful in
obtaining academic appointments globally is another achievement
of the PAMOT program. Our international trainees assuming faculty
positions in their country of origin also serve as international
ambassadors for The Hospital for Sick Children, the University of
Toronto and Canada. Trainees continue to reflect the international
nature of the fellowship program and the multi-disciplinary nature
of transplantation, as illustrated by the following selection of
recent trainees: Yaron Avitzur (Israel, Gastroenterology); Anne
Durkan (England, Nephrology); Sara Fernandez (Costa Rica,
Nephrology); Daljit Hothi (England, Nephrology); Victoria Samonte
(Philippines, Critical Care); and Jason Yap (New Zealand,
Gastroenterology).
Interim Director
Dr. David Grant
Transplant Physicians
and Surgeons
Dr. Upton Allen
Dr. Anne Dipchand
Dr. Walid Farhat
Dr. Annie Fecteau
Dr. Diane Hebert
Dr. Nicola Jones
Dr. Shaf Keshavjee
Dr. Tony Khoury
Dr. Simon Ling
Dr. Vicky Ng
Current basic and clinical research activities are focused on
optimizing outcomes in children after solid organ transplantation.
Examples of research projects with extramural funding include:
vaccination strategies; prevention of Epstein-Barr virus and
Respiratory Syncytial virus complications post-transplantation
(Upton Allen); long term quality of life following heart
transplantation (Anne Dipchand); xenotransplantation (David Grant);
adolescent issues of transition to adult care (Miriam Kaufman);
techniques to enhance lung recovery for transplantation (Shaf
Keshavjee); quality of life study in liver transplantation (Vicky Ng);
and leukocyte trafficking in allograft rejection (Lisa Robinson).
We continue active participation in international paediatric
transplantation clinical research groups including the North
American Pediatric Renal Transplant Cooperative Study Group,
the Pediatric Heart Transplant Study Group, NIH funded fulminate
liver failure study group, and the SPLIT of Pediatric Liver
Transplantation Registry. Members of PAMOT continued to serve as
advocates for paediatric solid organ transplantation at the
provincial, national and international levels including for example:
participation in the International Pediatric Lung Transplant
committee (Mindy Solomon); and membership on the Trillium Gift of
Life Board (David Grant, Diane Hebert).
Dr. Lisa Robinson
Dr. Mindy Solomon
Dr. Paul Wales
Paediatric Housestaff
PGY4S
Chief Residents
Dr. Sanjeev Luthra
Dr. Jonathon Maguire
Associate Chief Residents
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Heidi Al-Wassia
Youness Al-Darazi
Nirit Bernhard
Dan Flanders
Sloane Freeman
Elizabeth Gold
Fotini Kavadas
Shaun Morris
Nileshwa Senthe
Sarah Wan
PGY3S
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Ghassan Abu Kuwaik
Naifain Al-Kalbani
Nashat Al-Sukaiti
Daniela Ardelean
Celia Atkinson
Elly Berger
Karoon Danayan
Krishanthi Gunawardena
Clare Hutchinson
Marissa Joseph
Mary Kiaira
Vy Kim
Catherine Lam
Mathieu Lemaire
Carey McLaughlin
Michelle Porepa
Tania Samanta
Rayzie Shulman
Joanna Swinburne
Eitan Weinberg
PGY2S
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dalia Al-Abdulrazzaq
Fatoumah Al-Abdulrazzaq
Amal Al-Maani
Sowmya Balasubramanian
Ereny Bassilious
Michelle Batthish
Glenda Bendiak
Nicholas Blanchette
Michelle Bridge
Sumit Gupta
Joelene Huber
Sangeet Kathuria
Tarek Khalefih
Melanie Makhija
Shruti Mehrotra
Briseida Mema
Ewurabena Simpson
Andrea Wan
Kevin Weingarten
PGY1S
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Fahed Aljaser
Ahmed Alterkait
Kesete Bezu
Joyce Ching
Avram Denburg
Alisha Kassam
Rae Koffman
Dianne Lim
Nadia Luca
Arif Manji
Gagandeep Saund
Deena Savlov
Ksenia Slywynska
Gordon Soon
Christopher Sulowski
Mark Tessaro
Nisha Thampi
AlГЁne Toulany
Kirsten Wentlandt (PGY1 neuro)
PRACTICE READY ASSESSMENT (PRA)
Drs. Clare Hutchinson and Sanjeev Luthra
Dr. Wang Cheong Mak
Paediatric Grand Rounds
The 2006-07 academic year saw another successful and
exciting Department of Paediatrics Grand Rounds series.
The purpose of Paediatric Grand Rounds in the Department of
Paediatrics at the University of Toronto is to bring the world’s
most eminent clinicians, scientists, and medical educators to
SickKids. Grand Rounds provides an opportunity for SickKids’
faculty, house-staff, and students to experience cutting-edge
research relevant to the health care of children. All
presentations highlight the link between the bench and bedside,
demonstrating how new scientific advances translate into stateof-the-art health care for children.
The Grand Rounds program is organized by a committee that
consists of Drs. Meredith Irwin, Lisa Robinson, Jamie Hutchison,
Saul Greenberg, Johanna Rommens, Rayfel Schneider, Ron
Laxer, Neil Sweezey, Jill Hamilton, and Anne Opavsky, as well as
our paediatric Chief Residents, Drs. Jonathon Maguire and
Sanjeev Luthra.
One of the highlights of the 2006-07 series was the 2006
Robert H.A. Haslam Lecture, which was delivered by Dr. Denis
Daneman, incoming Chair of the Department of Paediatrics
here at SickKids. Dr. Daneman gave an interesting lecture on
the everyday challenges of caring for children with diabetes.
Dr. Georges Rivard, Director of the Haemostasis Program at
the Centre Hospitalier Universitaire Sainte-Justine in Montreal
gave a fascinating presentation on the genetics, diagnosis,
and emerging treatment options for haemophilia. Dr. Nicholas
Evans from the University of Sydney was invited to give the
2006 Barry Smith Lecture. He delivered a state-of-the-art
presentation on the role of assessment and support of the
transitional circulation in preventing brain injury to preterm
infants. Dr. Jeffrey Towbin, Director of the Heart Failure and
Cardiomyopathy Service at Texas Children’s Hospital and
Baylor College of Medicine, presented important findings
on the pathogenesis and outcomes of cardiomyopathies and
myocarditis in children. Dr. Robert Brent, Distinguished
Professor of Pediatrics, Radiology, and Pathology, and Head
of the Clinical and Environmental Teratology Research Lab at
Thomas Jefferson University presented his ground-breaking
research on children’s outcomes following exposure to radiation
during pregnancy. Other highlights included lectures from Drs.
Ulrika Kreicbergs (Children’s Hospital of Boston), Robert Truog
(Children’s Hospital of Boston), Brent Hagel (University of
Calgary), Eric Shoubridge (McGill University), Jessica Kahn
(Cincinnati Children’s Hospital), Martin Tobin (Loyola University
Hospital), Robert Black (Johns Hopkins University), Deborah Cook
(McMaster University), and Paul Sharek (Stanford University).
Once again this year, our own faculty delivered outstanding
presentations, including Drs. Sheila Weitzman (Haematology/
Oncology), Brian Feldman (Rheumatology), Stanley Zlotkin
(Gastroenterology, Hepatology, and Nutrition), and Upton Allen
(Infectious Diseases). Dr. Jill Hamilton from the Division of
Endocrinology and Dr. Gabrielle Boulianne from the Research
Institute program in Developmental and Stem Cell Biology gave
a memorable joint clinical science/basic science presentation.
Their work clearly illustrated how research studies using
fruit flies and clinical studies involving children can further
our understanding of obesity, a very common health problem
among children.
In addition to these lectures, our Associate Chief Residents
presented interesting cases from the paediatric service.
Dr. Lars Feuk from the Genetics and Genome Biology program
presented his research as the recipient of the 2007 Andrew
Sass-Kortsak Award for Excellence in Paediatric Research during
a Fellowship. These represent only a fraction of the outstanding
rounds which made up the 2006-07 series.
Grand Rounds will continue to be held on Wednesdays from
9:00 a.m. to 10:00 a.m. in the Main Auditorium at SickKids.
The Department of Paediatrics Grand Rounds Committee would
like to acknowledge the help and support of the following people,
to whom we are very grateful: The Paediatric Executive
Committee; Sylvia Muir, Division of Haematology/Oncology;
Valerie Daniels, Department of Paediatrics; and Frank Ferrari and
Sam Mendolia from the Audio-Visual Department at SickKids.
PAEDIATRIC GRAND ROUNDS
2006
Speaker
Presentation
2006
Speaker
Presentation
July 5-August 30 Summer Grand Rounds
Chief Residents
October 25
Stanley Zlotkin OC, MD, PhD, FRCPC
Division Head and Medical
Director of the Nutrition
Support Program, Division of
Gastroenterology, Hepatology
and Nutrition, SickKids
Micronutrient Sprinkles to
control childhood anemia:
Addressing an unresolved
global problem through
innovation, focused
research and partnerships
November 1
Sarah Cheang MD
Sanjeev Luthra MD
Elizabeth Gold MD
Residents, Department of
Paediatrics, SickKids
Associate Rounds –
Case presentations
November 8
Robert D. Truog MD
Professor of Medical Ethics and
Anaesthesia, Harvard Medical
School, Children’s Hospital
of Boston, Massachusetts
Donation after cardiac
death: The next great
advance in organ
transplantation?
Bioethics Week Lecture
September 6
September 13
No Grand Rounds
Sheila Weitzman
MB, BCh, FCP(SA), FRCPC
HLH – Diagnostic and
therapeutic dilemmas
Senior Staff Oncologist and
Director of Clinical Services,
Division of Haematology/
Oncology, SickKids
September 20
September 27
Jeffrey Towbin MD
Director, Heart Failure and
Cardiomyopathy Service
Baylor College of Medicine,
Texas Children’s Hospital
Houston, Texas
Cardiomyopathies and
myocarditis in children
Denis Daneman
The everyday challenges
of diabetes
2006 Robert Haslam
Lecture
MB, BCh, FRCPC
Chair, Department of
Paediatrics, SickKids
October 4
October 11
October 18
Brian Feldman MD, FRCPC
Staff Rheumatologist,
Division of Rheumatology,
SickKids
The quality of life
for children with
chronic illness
Ulrika Kreicbergs RN, PhD
Postdoctoral Research Fellow
Dana-Farber Cancer Institute,
Children’s Hospital Boston,
Boston, Massachusetts
Can we learn from those
who already know:
A nationwide study on
parents who lost their
child to cancer
Palliative Care Grand
Rounds
Georges Rivard MD
Director, Haemostasis Program
and the Haemostasis Clinical
Laboratory, Centre Hospitalier
Universitaire Sainte-Justine,
Montreal, Quebec
Haemophilia: From royal
genes to diagnosis and
treatment
2006 Bernard Laski
Lecture
November 15 Brent Hagel PhD
Department of Paediatrics and
Community Health Sciences,
Calgary, Alberta
November 22 Upton Allen MBBS, MSc, FAAP, FRCP The Epstein-Barr virus and
Head, Division of Infectious
weakened immune
Diseases, SickKids
systems: Hopes,
expectations and challenges
November 29 Eric Shoubridge PhD
Principal Investigator, Molecular
Neurogenetics, Molecular
Neurogenetics Institute, McGill
University, Montreal, Quebec
The assembly of the
respiratory chain and the
mystery of tissue specificity
in mitochondrial disease
2006 Jacob’s Ladder Lecture
December 6
The role of assessment and
support of the transitional
circulation in prevention of
brain injury to preterm babies
2006 Barry Smith Lecture
Nicholas Evans DM, MRCPCH
Clinical Associate Professor in
Neonatal Medicine, Royal Prince
Alfred Hospital, University of
Sydney, Sydney, Australia
December 13 Department of Paediatric
Residents
120
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
The reasons for and
against helmet use in
recreational activities:
What to tell your patients
and their parents
Annual Holiday Presentation
PAEDIATRIC GRAND ROUNDS
2007
Speaker
Presentation
January 3
No Grand Rounds
January 10
Associate Rounds #2
January 17
Jessica Kahn MD, MPH
Associate Professor of Pediatrics,
Cincinnati Children’s Hospital,
Cincinnati, Ohio
HPV: New vaccine, and
issues in adolescents
January 24
Martin Tobin MD
Professor of Medicine, Pulmonary,
and Critical Care Medicine,
Anesthesiology, Loyola University
Hospital, Maywood, Illinois
Evidence based
medicine issues
January 31
Berge Minassian MD
Canada Research Chair in
Paediatric Neurogenetics and
Staff Neurologist, SickKids
The paediatric genetics
epilepsies
February 7
Lorelei Lingard MD
Professional Educator, Medical
Education – Undergraduate,
Assistant Professor, Department
of Paediatrics, University of Toronto
Medical education
February 14
February 21
February 28
March 7
No Grand Rounds due to renovations
No Grand Rounds due to renovations
No Grand Rounds due to renovations
No Grand Rounds due to renovations
March 14
March Break
March 21
No Grand Rounds due to renovations
March 28
Robert Black MD, MPH
Professor and Chair, Department
of International Health,
Johns Hopkins University,
Baltimore, Maryland
April 4
No Grand Rounds due to renovations
Child survival in
developing countries:
Problems but promise
UHN Auditorium
2007
Speaker
Presentation
April 11
Deborah Cook MD, FRCPC, MSc(Epid)
Professor, Department of
Medicine, Clinical Epidemiology
and Biostatistics, Academic Chair,
Critical Care Medicine,
McMaster University, Ontario
Changing behaviour to
implement evidence
UHN Auditorium
April 18
No Grand Rounds due to renovations
April 25
Scott Halperin MD
Professor of Paediatrics,
Microbiology and Immunology
and Head, Paediatric Infectious
Diseases, Dalhousie University,
Halifax
May 2
SOCIETY OF PAEDIATRIC RESEARCH SEMINAR
May 9
Dr. Robert Brent AB, MD, PhD
Head, Clinical and Environmental
Teratology Research Lab,
A.I. DuPont Hospital for Children,
Distinguished Professor of Pediatrics,
Radiology and Pathology,
Thomas Jefferson University
Saving lives and changing
family histories: The
consequences of utilizing
appropriate and
inappropriate information
when counseling families
about developmental risks
Motherisk Lecture
May 16
Gabrielle Boulienne PhD
(Senior scientist)
Jill Hamilton MD (Associate
scientist and staff endocrinologist)
Exploring mechanisms for
weight gain: Lessons from
children with brain tumours
and fat flies
May 23
RESEARCH DAY
May 30
Sass-Kortsak Lecture
June 6
Dr. Paul Sharek MD
Stanford University
June 13
AWARDS DAY
June 20
Dr. John Pettifor MBBCH
Dept. of Paediatrics, Chris-Hani
Baragwanath Hospital and the
University of Witwatersrand,
South Africa
June 27
No Grand Rounds
DEPARTMENT OF PAEDIATRICS
Vaccines: What’s hot and
what is on the horizon
Paediatric Update Keynote
Lecture
Pediatric patient safety –
Defining and detecting
adverse events in children
Rickets in children –
How important is
dietary calcium intake?
ANNUAL REPORT 2006-07
121
Promotions/Recognition
PROMOTED TO PROFESSOR OF PAEDIATRICS
Dr. Anne Matlow
Dr. Jay Rosenfield
PROMOTED TO ASSOCIATE PROFESSOR OF PAEDIATRICS
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Elizabeth Asztalos
Anne Dipchand
Annette Feigenbaum
Gil Gross
Joel Kirsh
Vicky Ng
Suzan Schneeweiss
Vibhuti Shah
Gary Smith
THOSE WHO REACHED NORMAL RETIREMENT AGE
The following reached normal retirement age in June of 2007
Dr. Douglas Biggar
Dr. J. Michael Dorey
Dr. Raphael Folman
Dr. Howard Langer
Dr. Irena Nulman
Dr. Joyce Nesker Simmons
Dr. Arne Ohlsson
Dr. Eve Roberts
25 YEARS OF SERVICE AWARDS
The following were honoured for their 25 years of
service to The Hospital for Sick Children in June of 2007
Dr. Amos Cohen
Dr. Denis Daneman
Dr. Lee Ford-Jones
Dr. Miriam Rossi
Dr. Sheila Weitzman
Faculty Awards
AWARDS
Teaching/Education Awards
R.H.A. Haslam Preclerkship Teaching Award to the faculty member who
has demonstrated excellence in preclerkshop teaching
Dr. Lillian Rojnica
The Lionel Weinstein Clerkship Teaching Award to the faculty member
who has demonstrated excellence in clerkship teaching
Dr. Angelo Simone
The Undergraduate Community Teaching Award in recognition of
excellence in the teaching of medical students within community-based
hospitals and offices
Dr. Hartley Garfield
Harry Bain Award to a full-time member of the Department of Paediatrics
who has demonstrated excellence in teaching as nominated by core
paediatric residents
Dr. Michael Weinstein
Marvin Gerstein Award to a part-time member of the Department of
Paediatrics who has demonstrated excellence in teaching as nominated
by core paediatric residents
Dr. Norman Saunders
Postgraduate Community Teaching Award in recognition of excellence in
the teaching of paediatric residents within community-based hospitals
and offices
Dr. Douglas Campbell
PERLS Award (Paediatric Educational Resident Lecture Series Award)
to the faculty member who has demonstrated commitment to
excellence in teaching at the Paediatric academic sessions
Dr. Aru Bitnun
Subspecialty Teaching Award to the faculty member who has
demonstrated commitment to excellence in teaching the subspecialty
residents and clinical fellows
Dr. Elena Pope
Continuing Medical Education Award to the faculty member in recognition
of excellence in course coordination in an event sponsored by the
Department of Paediatrics/University of Toronto and/or long-term
contribution to Continuing Education in the Department of Paediatrics
Dr. Suzan Schneeweiss
Clinical Awards
Richard Rowe Award for Clinical Excellence in Paediatric Medical Care
to the physician in the Department of Paediatrics who has demonstrated
excellence in the delivery of clinical care in the broadest sense over a
significant period of time
Dr. Lee Benson
Junior Faculty Award for Clinical Excellence in Paediatric Medical Care
to a physican within the first 5-10 years of appointment to an Academic
Health Sciences Centre, who has demonstrated excellence in the
delivery of clinical care
Dr. Jill Hamilton
Research Awards
Physician Researcher Award for Scientific Accomplishment to recognize
the accomplishments of a physician who has generated a body of
research that is exerting a major impact in a field of study. The awardee
will be more than six and less than 15 years beyond the date of
appointment as a faculty member at an Academic Health Sciences
Centre. This award was first awarded in 2005.
Dr. Brian Feldman
Physician Research Award for Career Excellence to recognize sustained
excellence by a physician who has generated a body of work with
relevance beyond a specific field of study. The awardee will be 15 or
more years beyond the initial date of appointment as a faculty
member at an Academic Health Sciences Centre. This award was first
awarded in 2005.
Dr. Paul Pencharz
Paediatric Administrative Award
In recognition of an administrative support staff member in the
Department of Paediatrics who has demonstrated outstanding
performance and excellence in all aspects of their role. This individual
possesses outstanding communication and interpersonal skills and
is motivated to perform above and beyond their daily responsibilities.
This award was first awarded in 2007.
Ms. Shona Magee
Resident and Fellow Awards and Achievements
TEACHING/EDUCATION AWARDS
Christopher Ondaatje Award to a senior resident for excellence
in clinical teaching as nominated by core paediatric residents.
Dr. Joanna Swinburne
Dr. Jonathon Maguire
CanMEDS Award – Core Residents
Dr. Joelene Huber
Dr. Catherine Lam
Dr. Michelle Porepa
Elizabeth Stringer, Rheumatology
Predicting the disease course of juvenile dermatomyositis – Significance
of early and clinical laboratory features. E Stringer, D Singh-Grewal, R Laxer,
B Feldman
Mark Walsh, Cardiology
Left ventricular morphology and function predict outcome after Norwood
palliation. MA Walsh, BW McCrindle, A Dipchand, D Manlhiot, E Hickey,
CA Caldarone, GS Van Arsdell, SM Schwartz
Poster Presentations
CanMEDS Award – Subspecialty Fellow
Dr. Dan Turner
Shaker Abdullah, Haematology/Oncology
Expression of MYCN in paediatric synovial sarcoma. S Abdullah, M Zielenska,
C Sherman, S Chan, PS Thorner, GR Somers
CLINICAL AWARDS
The Saunders Prize to a senior resident who has demonstrated
excellence in clinical paediatrics.
Dr. Mathieu Lemaire
Samina Afzal, Haematology/Oncology
Role of lymphocyte recovery after allogeneic haematopoietic stem cell
transplantation in predicting relapse in paediatric acute leukaemia. S Afzal,
MK Ishaqi, J Doyle, A Gassas
RESEARCH AWARDS
Fadia Al-Buhairan, Adolescent Medicine
Paediatric Residents’ experiences in Adolescent Medicine. F Al-Buhairan,
K Leslie, E Goldberg
Junior Trainees
Dr. Catherine Lam
Dr. Elizabeth Berger
Senior Trainees – Clinical Science
Dr. Adam Kirton
Dr. Arvind Sehgal (Tie 2)
Dr. Mark Walsh (Tie 2)
Dr. Dragos Predescu (Tie 3)
Dr. Elizabeth Stringer (Tie 3)
Senior Tranees – Basic Science
Dr. Aleixo Muise (Tie 1)
Dr. Adam Durbin (Tie 1)
Todd R. Alexander, Nephrology
The cytosoloic C-terminus of NHE3 does not medicate its apical localization
or baseline activity – Implications for blood pressure and pH homeostasis.
RT Alexander, I Peltekova, A Durkan, S Grinstein
Samim Al-Qadhi, Emergency Medicine
A randomized controlled comparison of the effectiveness of different
teaching strategies on proficiency in intraosseous placement skills. S Al-Qadhi,
H Carnahan, A Dubrowski, S Mehta
Abdulkader Al-Rezqi, Infectious Diseases
Invasive mold infections in paediatric cancer and transplant patients:
An eight year review. A Al-Rezqi, M Hawkes, J Doyle, S Richardson, U Allen
ANNUAL RESIDENT AND FELLOW RESEARCH DAY
May 23, 2007
Oral Presentations
Chhaya S. Ambekar, Haematology/Oncology
Loss of Sbds results in dysregulation of Fas at the plasma membrane level.
CS Ambekar, H Wang, K-i Watanabe, A Schimmer, Y Dror
Elizabeth Berger, Core Paediatrics
Sickle cell disease in children: Osteomyelitis or vaso-occlusive crises?
E Berger, N Saunders, A Khambalia, JN Friedman
Juan Appendino, Neurology
EEG in newborns with sinus venous thrombosis. J Appendine, M Cortez,
E Sell, T Soma
Paul Gill, Nephrology
Suppressor of Fused is required for normal development of the murine
cerebellum. PS Gill, R Mo, C-C Hui, ND Rosenblum
Michelle Barton, Infectious Diseases
Immunogenicity of pneumococcal conjugate vaccine in paediatric solid organ
recipients. M Barton, S Wasfy, A Dipchand, D HГ©bert. V Ng, M Solomon, U Allen
April Kam, Emergency Medicine
Paediatric cellulitis: Success of Emergency Department short course
intravenous antibiotics. A Kam, J Leal, SB Freedman
Michelle Batthish, Rheumatology
Residents’ perceptions of an interactive web-based rheumatology teaching
module. M Batthish, E Bassilious, G Bendiak, S Gupta, B Feldman,
R Schneider, S Tse
Loretta Lau, Haematology/Oncology
HDM2 antagonist Nutlin-3 inhibits p73-HDM2 binding and activates p73.
L Lau, J Nugent, MS Irwin
Wanatpreeya Phongsamart, Infectious Diseases
Tuberculosis in children and adolescents in Ontario: A population-based
study. W Phongsamart, I Kitai, M Gardam, J Wang, K Khan, the Ontario
TB Outcome Study Network
Arvind Sehgal, Neonatology
Impaired coronary artery perfusion is associated with early myocardial
diastolic dysfunction in premature infants after ligation of the ductus
arteriosus. A Sehgal, PJ McNamara
Tina Biss, Haematology/Oncology
Clinical characteristics of pulmonary embolism in childhood – Experience
from a single centre. TT Biss, LR Brandao, AK Chan, S Williams
Darren J. Bridgewater, Nephrology
Beta-catenin controls murine kidney development and espression of kidney
patterning genes. DJ Bridgewater, ND Rosenblum
Aviel Y. Butbul, Rheumatology
Juvenile psoriatic arthritis (JPSA) is it a separate disease? AY Butbul,
S Dhillon, PN Tyrell, ED Silverman
Jason E. Cain, Nephrology
Lineage specific functions of GLI activators during murine kidney development.
JE Cain, E Nieuwenhuis, C-C Hui, ND Rosenblum
Harold Chui, Adolescent Medicine
Impact of weight and menstrual function recovery on brain structure and
function in adolescent-onset anorexia nervosa. HT Chui, B Christensen,
RB Zipursky, DK Katzman
Min Rui Crow, Nephrology
Neuronal guidance cues Slit and Robo – new inhibitors of leukocyte
trafficking. MR Crow, M Yan, G-Y Liu, S Tole, LA Robinson
Roberto Jose Diaz, Haematology/Oncology
Assessment of chemotherapeutic response in paediatric patients with optic
nerve gliomas associated with proptosis. RJ Diaz, S Laughlin, R Buncic,
G Nicolin, E Bouffet, U Bartels
Valeria E. Di Giovanni, Nephrology
The BMP receptor, ALK3, controls murine nephrogenesis. VE Di Giovanni,
ND Rosenblum
Gaute Dohlen, Cardiology
Improving outcomes in high risk tetralogy of Fallot patients with right
ventricular outflow tract stenting. G Dohlen, LN Benson, RR Chaturvedi,
A Ozawa, D Fruitman-Power, K-J Lee
Adam Durbin, Haematology/Oncology
A JNK-dependent activation switch determines the oncogenic or tumour
suppressive activity of integrin-linked kinase in rhabdomyosarcoma.
AD Durbin, GR Somers, M Forrester, GE Hannigan, D Malkin
Walid I. El-Nagger, Neonatal-Perinatal Medicine
Role of amplitude integrated electroencephalography (aEEG) in Neonates
with cardiovascular compromise. WI El-Naggar, M Keyzers, PJ McNamara
Amr El Shahed, Neonatal-Perinatal Medicine
Surfactant for meconium aspiration syndrome in full term infants.
AI El Shahed, P Dargaville, A Ohlsson, RF Soll
Emer Finan, Neonatal-Perinatal Medicine
Clinical predicators of post-ligation cardiac syndrome (PLCS) in neonates.
E Finan, SP Shivananda, L Teixeira, W Mak, PJ McNamara
Ayataka Fujimoto, Neurology
Magnetoencephalographic interictal epileptiform discharges under total intra
venous anesthesia in children with lesion or non-lesion epilepsy. A Fujimoto,
A Ochi, K Imai, R Sharma, A Hunjan, B Chu, S Holowka, SM Kemp,
SH Chuang, A Matsumura, C Snead III, H Otsubo
Alya Galtseva, Nephrology
GLI3 is expressed in the primary cilium in the murine embryonic kidney.
A Galtseva, C-C Hui, ND Rosenblum
Facundo Garcia-Bournissen, Clinical Pharmacology
External contamination of hair with MDMA (Ecstasy) determined by hair
analysis in two young girls from a meth lab. F Garcia-Bournissen, F Asrar,
Z Verjee, T Karaskov, G Koren
Joshua Greenberg, Haematology/Oncology
Rhabdomyosarcoma cells have an active estrogen receptor-ОІ-mediated
pathway that exhibits sensitivity to estrogen, and undergo apoptosis in
response to 4’OH-Tamoxifen. JA Greenberg, S Somme, R Giercksky, D Malkin
Lars Grosse-Wortmann, Cardiology
Magnetic resonance imaging in the preoperative assessment of marginally
hypoplastic left ventricles. L Grosse-Wortmann, TJ Yu, O Al-Radi, S-J Yoo,
G van Arsdell, A Redington
Michael Hawkes, Infectious Diseases
Development of Canadian guidelines for the prevention and management of
community-associated methicillin-resistant Staphylococcus aureus in Canada:
an example of knowledge translation in a CanMEDS framework. M Hawkes,
M Barton, EL Ford-Jones
Joelene Huber, Core Paediatrics
Kids on Kids’ Health: Creating a child health magazine with students from
an urban, multicultural, low income elementary school. JF Huber, M Porepa,
C Lam, H Au, CS Birken
Ryan Hung, Neurology
Vitamin D levels, vitamin D intake and sunlight exposure in paediatric multiple
sclerosis. R Hung, R Vieth, R Goldman, E Sochett, B Banwell
Miho Inoue, Clinical Pharmacology
Safety of Ketorolac for analgesia in children after cardiac surgery. M Inoue,
CA Caldarone, PN Cox, S Ito, H Frndova, A Taddio, AM Guerguerian
Mohammed Kashif Ishaqi, Haematology/Oncology
Outcome of allogeneic haematopoietic stem cell transplantation for children
with acute myelogenous leukaemia in second complete remission, single
center experience. MK Ishaqi, S Afzal, A Dupuis, J Doyle, A Gassas
Shailly Jain, Medical Genetics
Increased elastolysis in Cutis Marmorata Telangiectasis Congenita. S Jain,
A Hinek, M Beghetti, H Tresurer, G Taylor, M Silver, D Nykanen, D Chitayat
Anita Jethwa, Developmental Paediatrics
The development and evaluation of the HAT-D: A discriminative tool
differentiating types of hypertonia in children. A Jethwa, D Fehlings,
C Macarthur
Ben-Hur Johnson, Neonatal-Perinatal Medicine
Role of IL-1 in the neonatal rat model of chronic lung injury induced
by exposure to 60% oxygen. B-H Johnson, M Yi, S Shek, R Belcastro,
A Masood, RP Jankov, AK Tanswell
Kassia Johnson, Developmental Paediatrics
Books for siblings of children with Autism: Children’s assessments.
K Johnson, P McKeever, A Kawamura
Roman Jurencak, Rheumatology
Antibody clustering in paediatric systemic lupus erythematosus (SLE).
R Jurencak, M Fritzler, P Tyrell, L Hiraki, E Silverman
Fotini Kavadas, Immunology/Allergy
Antibiotic skin testing for children labeled with Type 1 hypersensitivity:
A useful clinical tool. FD Kavadas, KR Seaban, Y Nofech-Mozes, M Husain,
E White, AR Atkinson
Adam Kirton, Neurology
Novel corticospinal tract pre-wallerian degeneration in paediatric stroke:
Acute MRI prediction of outcome and TMS correlates of reorganization.
A Kirton, T Domi, R Chen, M Shroff, C Gunray, E Kouzmitcheva, G deVeber
Dror Koltin, Endocrinology
Idiopathic infantile hypercalcemia (IIH) revisited: Positive results in a cohort
of 20 infants screened for mutations of the calcium sensing receptor (CASR)
gene. D Koltin, M Rachmiel, EB Sochett, K Parker, BYL Wong, DEC Cole
Catherine Lam, Core Paediatrics
Efficacy of intravenous immunoglobulin therapy in juvenile dermatomyositis.
C Lam, C Manlhiot, E Pullenayegum, PN Tyrell, BM Feldman
Andrew C. Lau, Rheumatology
Induction of MMP-9 by inflammatory cells leads to coronary artery
aneurysm formation in a murine model of Kawasaki Disease. AC Lau,
TT Duong, S Ito, RS Yeung
DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
127
Elana Lavine, Immunology/Allergy
Clinical course and immunological features of siblings with IRAK-4
deficiency. E Lavine, C Roifman
Melanie Makhija, Infectious Diseases
Paediatric neurocysticercosis – A twenty year review. M Makhija, J Brophy,
D Tran, L Ford-Jones, J Keystone
Azhar Masood, Neonatal-Perinatal Medicine
Therapeutic hypercapnia protects against chronic neonatal lung injury, and
prevents vascular remodeling, in the neonatal rat. A Masood, RP Jankov,
M Yi, R Balcastro, S Shek, PJ McNamara, AK Tanswell
Chantal Morel, Medical Genetics
Cord blood stem cell transplantation in Niemann-Pick type 1A. CF Morel,
A Gassas, J Doyle, JTR Clarke
Aleixo Muise, Gastroenterology/Nutrition
Protein tyrosine phosphate sigma is a susceptibility gene for ulcerative
colitis. A Muise, A Griffiths, D Rotin
Angela Orsino, Developmental Paediatrics
A qualitative observational study of resident oral paediatric developmental
case presentations. A Orsino, A Kawamura, L Lingard
Joanne F. Paul, Emergency Medicine
Perceptions of Paediatric Emergency Medicine fellows and program directors
about their fellowship resuscitation teaching curricula. JF Paul, S Mehta
Jonathan S. Ponesse, Developmental Paediatrics
Patterns of nervous system and somatic malformation in Comorbid Mobius
Syndrome and Autism Spectrum Disorder. JS Ponesse, H Wood, I Drmic,
W Roberts
Michelle Porepa, Core Paediatrics
The diagnostic utility of MRI in differentiating between acute osteomyelitis
and acute osteoinfarction in children with sickle cell disease. M Porepa,
CS Birken, PS Babyn, A Doria, PC Parkin
Dragos Predescu, Cardiology
Resting cardiac index, ejection fraction and exercise capacity in a paediatric
heart failure clinic population. D Predescu, G Smith, C Slorach,
AN Redington, PF Kantor
Rodica Retazar, Emergency Medicine
Spinal injuries in paediatric trauma patients. R Retazar, V Wu, P Wales,
A Mikrogianakis
Dan W. Rhodes, Clinical Pharmacology
Calls to a support center for pregnant and planning women regarding
exposures: the Motherisk Program. DW Rhodes, G Koren
Tal Schechter, Haematology/Oncology
Dosing adequacy and safety of unfractionated heparin in infants with
thrombotic complications. T Schechter, Y Finkelstein, S Williams, AK Chan,
M Ali, LR Brandao
Shazhan, Amed, Endocrinology
Risk factors for Type 2 Diabetes (T2D) in youth with medication induced
Diabetes (MID). A Shazan, H Dean, J Hamilton, NT1DM Study Team
Sandesh Shivananda, Neonatal-Perinatal Medicine
Is 02 administration safe during transport of neonates with CHD.
S Shivananda, K Muthulaly, H Whyte, P McNamara
Adam Shlien, Haematology/Oncology
Genomic DNA copy number variations in Li-Fraumeni Syndrome:
Distinguishing heritable and nonheritable tumours. A Shlien, M Pienkowska,
B Baskin, S Nanda, H Druker, U Tabori, P Ray, D Malkin
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DEPARTMENT OF PAEDIATRICS
ANNUAL REPORT 2006-07
Lyn Sonnenberg, Developmental Paediatrics
Addressing the rehabilitation needs of children with Spina Bifida in Kenya
using participatory rural appraisal and community based rehabilitation:
Bridging the gap. LK Sonnenberg, WD Biggar, T Kennedy, J Wee, R Bransford
Arthur Staroselsky, Clinical Pharmacology
Prenatal alcohol and parental psychopathology predict childhood
behaviours: Preliminary results. A Staroselsky, E Fantus, G Koren, P Sandor,
I Nulman
Emily W.Y. Tam, Neurology
Cerebellar diffusivity on neuroimaging correlates with intraventricular
hemorrhage in the preterm neonate. EWY Tam, SP Miller, D Xu, JI Berman,
DB Vigneron, AJ Barkovich, DM Ferriero
Marilyn Tan, Neurology
Occipital bone compression of the superior sagittal sinus as a contributory
factor in neonatal cerebral sinovenous thrombosis. M Tan, M Shroff,
G deVeber, M Moharir, A Pontigon, A Kirton
Toshihiro Tanaka, Clinical Pharmacology
The incidence of poor neonatal adaptation syndrome after intrauterine
exposure to venlafaxine. T Tanaka, J Choi, Y Nomura, A Eirarson, G Koren,
S Ito
Tony Truong, Haematology/Oncology
Features at presentation predict children with acute lymphoblastic
leukaemia at low risk for tumour lysis syndrome. T Truong, J Beyene,
J Hitzler, O Abla, AM Maloney, S Weitzman, L Sung
Aoife Waters, Nephrology
Ectopic notch activation in podocytes leads to structural alterations of the
glomerular slit diaphragm. AM Waters, M Wu, T Onay, TD Piscione
Constance Williams, Neonatal-Perinatal Medicine
Do Neonatal Intensive Care Units follow parents’ preferences in withdrawal
of life- sustaining treatment? C Williams, H Kirpalani
Etan Wine, Gastroenterology/Nutrition
A model of pathogen-induced intestinal barrier injury in chronic
inflammatory bowel diseases: Campylobacter jejuni-mediated disruption of
polarized epithelial cell monolayers. E Wine, PM Sherman
Derek Wong, Cardiology
Intra-operative trans-esophageal coronary Doppler flow patterns in patients
with D-Transposition of the great arteries undergoing arterial switch
operation. D Wong, L Hess, F Golding, C Calderone, B McCrindle, C Malhout,
L Nield
Man Yi, Neonatal-Perinatal Medicine
Inhibition of apoptosis in 60% oxygen-induced neonatal rag lung injury.
M Yi, A Ziino, B-H Johnson, A Masood, R Jankov, K Tanswell
Meijian Zhao, Neonatal-Perinatal Medicine
Cisapride exerts a prokinetic effect in infants with abdominal wall defects
and severe dysmotility. M Zhao, NT de Silva, AM Moore, JH Kim
Adrian J.A. Ziino, Neonatal-Perinatal Medicine
Role of cyclooxygenase-2 in 60% oxygen-medicated lung injury and
alveolar formation in the neonatal rat. AJA Ziino, M Yi, R Belcastro, S Shek,
CR Pace-Asciak, RP Jankov, AK Tanswell
Mohammed Zolaly, Haematology/Oncology
Non-Hodgkin’s lymphoma in children under 5 years of age. M Zolaly,
S Weitzman, A Naqvi, O Abla
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