Dangerous Liaisons translating cancer biology into better patients management 56th Annual Meeting of the Italian Cancer Society Ferrara, 11-13 September 2014 Università degli Studi di Ferrara 56 th Annual Meeting of the Italian Cancer Society Dangerous Liaisons translating cancer biology into better patients management CONGRESS VENUE Università degli Studi di Ferrara - Via Luigi Borsari, 46 - 44121 Ferrara OPENING CEREMONY VENUE Azienda Ospedaliero Universitaria di Ferrara Arcispedale Sant’Anna - Via Aldo Moro, 8 - 44124 Cona – Ferrara SIC SECRETARIAT Società Italiana di Cancerologia Via G. Venezian, 1 - 20133 Milan, Italy Phone +39 02 2666895 - Fax +39 02 2664342 E-mail: [email protected] www.cancerologia.it ORGANIZING SECRETARIAT C.S.C. S.r.l. Via L.S. Gualtieri, 11 - 06123 Perugia Tel+390755730617 - Fax +390755730619 www.csccongressi.it 2 With the auspices of COMUNE DI FERRARA Città Patrimonio dell’Umanità 3 56th Dangerous Liaisons translating cancer biology into better patients management Committee SIC SCIENTIFIC BOARD President Silvia Giordano (Candiolo Cancer Institute - FPO, IRCCS, University of Turin, Candiolo, Italy) President Elect Gabriella Sozzi (IRCCS National Cancer Institute, Milan, Italy) Board Rita Falcioni (Regina Elena National Cancer Institute, Rome, Italy) Davide Melisi (University of Verona, Italy) Nicola Normanno (National Cancer Institute “G. Pascale”, Naples, Italy) Massimo Santoro (“Federico II” University, Naples, Italy) Elda Tagliabue (IRCCS National Cancer Institute, Milan, Italy) Giulia Taraboletti (“Mario Negri” Institute for Pharmacological Research, Bergamo, Italy) Giuseppe Viglietto (University of Magna Græcia, Catanzaro, Italy) Members under 35 Marco Macagno (University of Turin, Italy) Selena Ventura (Orthopaedic Rizzoli Institute, Bologna, Italy) Past President Riccardo Dolcetti (CRO-IRCCS, National Cancer Institute, Aviano, Pordenone, Italy) SCIENTIFIC AND ORGANIZING COMMITTEE Scientific Coordinator Massimo Negrini (University of Ferrara, Italy) Local Scientific Committee Silvano Capitani, (University of Ferrara, Italy) Giorgio Cavallesco, (University Hospital of Ferrara, Italy) Antonio Cuneo, (University Hospital of Ferrara, Italy) Francesco Di Virgilio, (University of Ferrara, Italy) Antonio Frassoldati, (University Hospital of Ferrara) Giovanni Lanza, (University Hospital of Ferrara, Italy) Alberto Liboni, (University Hospital of Ferrara, Italy) Paolo Pinton, (University of Ferrara, Italy) Silvia Sabbioni, (University of Ferrara, Italy) Mauro Tognon, (University of Ferrara, Italy) Stefano Volinia, (University of Ferrara, Italy) 4 Faculty Reuven Agami Cancer Institute - Amsterdam, The Netherlands Mattia Boeri IRCCS National Cancer Institute - Milan, Italy James Brenton Cancer Research UK Cambridge Institute - University of Cambridge, UK George Adrian Calin MD Anderson Cancer Center - University of Texas, Houston, Texas, USA Silvano Capitani University of Ferrara, Italy Carlo M. Croce Ohio State University - Columbus, Ohio, USA Ruggero De Maria Regina Elena National Cancer Institute - Rome, Italy Pier Paolo Di Fiore IFOM-IEO Campus - Milan, Italy Francesco Di Virgilio University of Ferrara, Italy Janine Erler BRIC-Biotech Research & Innovation Centre - University of Copenhagen, Denmark Rita Falcioni Regina Elena National Cancer Institute - Rome, Italy Brunangelo Falini University of Perugia, Italy Antonio Frassoldati University Hospital of Ferrara Gaia Cristina Ghedini IRCCS National Cancer Institute - Milan, Italy Christopher Heeschen Spanish National Cancer Research (CNIO) - Madrid, Spain Enrico Iaccino University Magna Graecia - Catanzaro, Italy Marilena Iorio IRCCS National Cancer Institute - Milan, Italy Simon Joosse University Medical Center- Hamburg, Eppendorf , Germany Guido Kroemer INSERM, Institut Gustave Roussy - Villejuif, France Marco Macagno University of Turin, Italy Valerie Matarese UpTo infotechnologies - Vidor, Italy Alberto Mantovani University of Milan, Italy Davide Melisi University of Verona, Italy Andrea Morandi University of Florence, Italy Massimo Negrini University of Ferrara, Italy Clara Nervi University La Sapienza - Rome, Italy Nicola Normanno National Cancer Institute “G. Pascale” - Naples, Italy Pier Paolo Pandolfi Beth Israel Deaconess Medical Center - Boston, Massachussets, USA Pier Giuseppe Pelicci IFOM-IEO Campus - Milan, Italy Paolo Pinton University of Ferrara, Italy Ymera Pignochino Institute for Cancer Research and Treatment - Candiolo, Turin, Italy Vito Pistoia Gaslini Children’s Hospital - Genoa, Italy Valeria Poli University of Turin, Italy Sabina Sangaletti IRCCS National Cancer Institute - Milan, Italy Gabriella Sozzi IRCCS National Cancer Institute - Milan, Italy Elda Tagliabue IRCCS National Cancer Institute - Milan, Italy Giulia Taraboletti “Mario Negri” Institute for Pharmacological Research - Bergamo, Italy Giampaolo Tortora University of Verona, Italy Giuseppe Viglietto University of Magna Græcia - Catanzaro, Italy Selena Ventura Orthopaedic Rizzoli Institute - Bologna, Italy Stefano Volinia University of Ferrara, Italy 5 Programme at a glance Thursday September 11th - AULA MAGNA - OSPEDALE CONA 10.00 - 13.00 Pre-Meeting SIC young investigators 14.00 - 14.30 Welcome Opening 14.30 - 15.15 Opening Lecture 15.15 - 18.30 Session 1: Cancer Microenvironment and Inflammation 19.00 - 19.15 Bus Transfer 19.15 - 22.00 Welcome Cocktail Friday September 12th - POLO CHIMICO BIO MEDICO (Mammut) 08.00 Registration and poster hanging 08.30 - 10.30 Session 2: Non Coding RNAs and Epigenetics 10.30 - 11.00 Coffee Break 11.00 - 13.00 Poster Viewing with Authors 13.00 - 14.00 Light Lunch 14.00 - 15.30 Poster Discussion (4 parallel sessions) 15.30 - 16.45 Session 3a: Cancer Stem Cells 16.45 - 17.15 Coffee Break 17.15 - 18.00 Session 3b: Cancer Stem Cells 18.15 - 19.15 SIC General Assembly 20.15 Social Dinner Saturday September 13th - POLO CHIMICO BIO MEDICO (Mammut) 08.30 - 09.15 Plenary Lecture 09.15 - 11.30 Session 4: “Translational” Therapy 11.30 - 12.30 Award Ceremony 12.30 - 13.30 Light Lunch 13.30 - 14.15 Giorgio Prodi Lecture 14.15 - 15.45 Session 5: Translational Diagnostics: NGS, Circulating Cells\Nucleic Acids 15.45 - 16.30 Closing Lecture 16.30 - 17.00 Closing Remarks 6 Thursday September 11th Scientific Programme Venue: AULA MAGNA - OSPEDALE CONA 10.00 - 13.00 PRE-MEETING SIC YOUNG INVESTIGATORS Chairs: Marco Macagno (Turin, Italy), Selena Ventura (Bologna, Italy) “Writing Grant Proposals: three techniques to present your idea with clarity and conviction” Valerie Matarese Ph.D. (Vidor, TV) Meeting of SIC young investigators 14.00 - 14.30 WELCOME OPENING 14.30 - 15.15 OPENING LECTURE Causes and Consequences of microRNA Dysregulation in Cancer Carlo M. Croce (Columbus, Ohio, USA) 15.15 - 18.30 Session 1: CANCER MICROENVIRONMENT AND INFLAMMATION Chairs: Francesco Di Virgilio (Ferrara, Italy), Andrea Morandi (Florence, Italy) Immunosuppressive microenvironnment in neuroblastoma Vito Pistoia (Genoa, Italy) New players and targets in tumor vasculature Ugo Cavallaro (IEO, Istituto Europeo di Oncologia, Milan, Italy), Elena Magrini, Fabrizio Bianchi, Andrea Doni, Francesca Angiolini, Alessandra Villa, Massimiliano Mazzone The transcritpion factor STAT3 at the crossroad between cancer and inflammation Valeria Poli (Turin, Italy) Stable modulation of the glycolytic phenotype of tumor cells by anti-VEGF therapy Stefano Indraccolo (Istituto Oncologico Veneto, IRCCS, Padua, Italy), Matteo Curtarello, Elisabetta Zulato, Giorgia Nardo, Silvia Valtorta, Giulia Guzzo, Elisabetta Rossi, Giovanni Esposito, Aichi Msaki, Andrea Rasola, Luca Persano, Francesco Ciccarese, Roberta Bertorelle, Sergio Todde, Mario Plebani, Henrike Schroer, Stefan Walenta, Wolfgang MuellerKlieser, Alberto Amadori, Rosa Maria Moresco The extracellular matrix at the interface between immunity and cancer Sabina Sangaletti (Milan, Italy) Matrix remodelling during cancer progression Janine Erler (Copenhagen, Denmark) 15.15 - 15.45 15.45 - 16.00 V9 16.00 - 16.30 16.30 - 16.45 V 17 16.45 - 17.15 17.15 - 17.45 17.45 - 18.30 PLENARY LECTURE Molecular pathways linking inflammation and cancer Alberto Mantovani (Milan, Italy) 19.00 - 19.15 19.15 - 22.00 BUS TRANSFER Welcome Cocktail 7 Friday September 12th Scientific Programme Venue: POLO CHIMICO BIO MEDICO (Mammut) 08.00 REGISTRATION AND POSTER HANGING 08.30 - 10.30 Session 2: NON CODING RNAS AND EPIGENETICS Chairs: Massimo Negrini (Ferrara, Italy), Stefano Volinia (Ferrara, Italy) 08.30 - 09.00 About Noam Chomsky, DNA patterns, Non-codingRNAs and Cancer patients George A. Calin (Houston, Texas, USA) 09.00 - 09.15 Targeting aberrant HDAC4 activity in multiple myeloma (MM) through a miR-29bbased therapeutic strategy Nicola Amodio (Department of Experimental and Clinical Medicine, University Magna Graecia R2 of Catanzaro, Catanzaro, Italy), Marzia Leotta, Eugenio Morelli, Maria Angelica Stamato, Lavinia Raimondi, Anna Maria Gullà, Maria Teresa Di Martino, Teresa Calimeri, Marco Rossi, Antonino Neri, Pierosandro Tagliaferri, Pierfrancesco Tassone 09.15 - 09.45 EnhancerRNAs at the service of p53 Reuven Agami (Amsterdam, The Netherlands) 09.45 - 10.00 Mir-660 is downregulated in lung cancer patients and its replacement inhibits lung tumorigenesis by targeting MDM2-p53 interaction Orazio Fortunato (Fondazione IRCCS Istituto Nazionale dei Tumori, Tumor Genomics Unit, R9 Milan), Mattia Boeri, Massimo Moro, Carla Verri, Mavis Mensah, Davide Conte, Luca Roz, Ugo Pastorino, Gabriella Sozzi 10.00 - 10.30 The epigenetic role of microRNA-223 in hematopoiesis and leukemias Clara Nervi (Roma, Italy) 8 10.30 - 11.00 Coffee Break 11.00 - 13.00 13.00 - 14.00 POSTER VIEWING WITH AUTHORS Light Lunch Friday September 12th Scientific Programme Venue: POLO CHIMICO BIO MEDICO (Mammut) 14.00 - 15.30 14.00 - 15.30 POSTER DISCUSSION (4 PARALLEL SESSIONS) Poster Discussion 1 Room E2 CANCER GENETICS, EPIGENETICS AND CONTROL OF GENE EXPRESSION Chairs: Marilena Iorio (Milan, Italy), Giuseppe Viglietto (Catanzaro, Italy) B 18 Searching for Oncogenic Drivers in the Stepwise Process of Hepatocarcinogenesis Patrizia Zavattari (Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy), Andrea Perra, Marta Anna Kovalik, Maria Maddalena Angioni, Silvia Menegon, Annalisa Petrelli, Luca Quagliata, Giovanna Maria Ledda-Columbano, Luigi Terracciano, Silvia Giordano, Amedeo Columbano B8 Involvement of ALK in Pediatric Rhabdomyosarcoma Patrizia Gasparini (Experimental Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Hospital, Milan, Italy), Raffaella Villa, Michela Casanova, Paola Collini, Rita Alaggio, Roberto Caserini, Monica Tortoreto, Nadia Zaffaroni, Cristina Meazza, Maria Grazia Daidone, Maura Massimino, Andrea Ferrari, Gabriella Sozzi B 14 Whole Exome Sequencing revealed a novel PALB2 mutation in a male breast cancer family Valentina Silvestri(Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy), Piera Rizzolo, Anna Sara Navazio, Virginia Valentini, Veronica Zelli, Giovanni Chillemi, Marco Montagna, Laura Ottini C2 Impairment of V-ATPase as a therapeutic modality targeting cancer stem cells of rhabdomyosarcoma Sofia Avnet (Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico Rizzoli, Bologna, Italy), Manuela Salerno, Shigekuni Hosogi, Nicola Baldini C 13 Hedgehog-Gli signaling pathway in lung cancer stem cells and its drug mediated targeting Agnese Po (Dipartimento di Medicina Molecolare, Sapienza Università di Roma, Roma, Italy), Marianna Silvano, Danilo Cucchi, Adriana Eramo, Evelina Miele, Valentina Salvati, Giovanni Sette, Ruggero De Maria, Ann Zeuner, Enrico De Smaele, Alberto Gulino, Elisabetta Ferretti R5 miRNA and gene regulatory pathway of stage I epithelial ovarian cancer: reconstructing cancer circuits Enrica Calura (Department of Biology, University of Padova, Padua, Italy), Gabriele Sales, Paolo Martini, Robert Fruscio, Eliana Bignotti, Antonella Ravaggi, Lara Paracchini, Mariacristina Di Marino, Laura Zanotti, Dionyssios Katsaros, Germana Tognon, Enrico Sartori, Sergio Pecorelli, Maurizio D’Incalci, Sergio Marchini, Chiara Romualdi R 12 Regulation of microRNA processing by mutp53 in colon cancer Francesca Garibaldi (IFO-Istituti Fisioterapici Ospitalieri, Istituto Nazionale dei tumori Regina Elena, Rome, Italy), Emmanuela Falcone, Gianluca Bossi, Daniela Trisciuoglio, Giulia Piaggio, Aymone Gurtner 9 Friday September 12th Scientific Programme Venue: POLO CHIMICO BIO MEDICO (Mammut) 14.00 - 15.30 Poster Discussion 2 MICROENVIRONMENT AND TUMOR IMMUNOLOGY Chairs: Enrico Iaccino (Catanzaro, Italy), Giulia Taraboletti (Bergamo, Italy) D4 An Angiopoietin-like Protein 2 autocrine signaling promotes EMT during pancreatic ductal carcinogenesis Carmine Carbone (Digestive Molecular Clinical Oncology Research Unit, Università degli Studi di Verona, Verona, Italy), Geny Piro, Matteo Fassan, Anna Tamburrino, Maria Mihaela Mina, Marco Zanotto, Paul J Chiao, Claudio Bassi, Aldo Scarpa, Giampaolo Tortora, Davide Melisi D5 Endothelial podosome rosettes regulate vascular branching in tumor angiogenesis Giulia Chiaverina (Institute for Cancer Research and Treatment, Department of Oncology, University of Torino, Turin, Italy, Candiolo, Italy), Giorgio Seano, Paolo Armando Gagliardi, Laura di Blasio, Alberto Puliafito, Roberto Sessa, Claire Bouvard, Guido Tarone, Dominique Helley, Lydia Sorokin, Guido Serini, Federico Bussolino, Luca Primo D 15 Cadherin 6 and thyroid cancer: beyond a structural function Valentina Sancisi (Laboratory of Translational Research, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy), Greta Gandolfi, Moira Ragazzi, Ione Tamagnini, Simonetta Piana, Alessia Ciarrocchi F7 Metabolic control of YAP and TAZ by the mevalonate pathway Giovanni Sorrentino (Laboratorio Nazionale CIB, Università degli studi di Trieste, Trieste, Italy), Naomi Ruggeri, Valeria Specchia, Michelangelo Cordenonsi, Miguel Mano, Sirio Dupont, Andrea Manfrin, Eleonora Ingallina, Roberta Sommaggio, Silvano Piazza, Antonio Rosato, Stefano Piccolo, Giannino Del Sal V1 The multifaceted anti-tumor activity of interleukin-27 in human lung cancer Irma Airoldi (Laboratory of Oncology, Istituto Giannina Gaslini, Genoa, Italy), Silvia Esposito, Maria Grazia Tupone, Giulia Barbarito, Marco Vincenzo Russo, Serena Di Meo, Carlo Sorrentino, Emma Di Carlo V 26 Mast Cell-Derived IL-8 Induces Epithelial-to-Mesenchymal Transition and Stem Cell Features in Human Thyroid Cancer cells Carla Visciano (Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Istituto per L’Endocrinologia e l’Oncologia Molecolare del CNR, University of Naples, Federico II, Naples, Italy), Federica Liotti, Nella Prevete, Gaetano Calì, Renato Franco, Francesca Collina, Amato de Paulis, Gianni Marone, Massimo Santoro, Rosa Marina Melillo U2 The complement system in the immunosurveillance of HER-2 positive mammary cancer Silvio Bandini (Molecular Biotechnology Center, University of Turin, Turin, Italy), Marco Macagno, Albana Hisi, Laura Conti, Stefania Lanzardo, Amanda Bello, Manuela Iezzi, Federica Cavallo 10 Room E3 Friday September 12th Scientific Programme Venue: POLO CHIMICO BIO MEDICO (Mammut) 14.00 - 15.30 Poster Discussion 3 BIOMARKERS AND THERAPY Chairs: Ymera Pignochino (Turin, Italy), Selena Ventura (Bologna, Italy) Room D6 L8 A specific c-MET inhibitor (JNJ-38877605) reduces bone metastases induced by kidney cancer stem cells in a human-in-mice model Ilaria Roato (CeRMS -Center for Research and Medical Studies- A.O. Città della Salute e della Scienza di Torino, Turin, Italy), Livio Trusolino, Lucia D’Amico, Giorgia Migliardi, Roberta Pulito, Timothy Perera, Paolo M. Comoglio, Riccardo Ferracini L2 Establishment of a platform of patient-derived tumor xenografts (EOC-PDX) to study the biology and therapy of epithelial ovarian cancer Francesca Bizzaro (Department of Oncology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy), Francesca Ricci, Marta Cesca, Federica Guffanti, Alessandra Decio, Carmen Ghilardi, Patrizia Perego, Robert Fruscio, Paola Ostano, Giovanna Chiorino, Maria Rosa Bani, Giovanna Damia, Raffaella Giavazzi P 16 Evaluation by multicolor flow cytometry of circulating endothelial cells as prognostic and predictive biomarker in healthy donors and colorectal cancer patients Alessandra Leone (Istituto Nazionale per lo Studio e la Cura dei Tumori, ‘Fondazione Giovanni Pascale’- IRCCS – Italia, Naples, Italy), Maria Serena Roca, Carlo Vitagliano, Francesco Bianco, Silvia De Franciscis, Gianluca Rotta, Ernesta Cavalcanti, Rosa Azzaro, Annamaria Diodato, Carmela Cacciapuoti, Guglielmo Nasti, Antonio Avallone, Alfredo Budillon, Elena Di Gennaro P3 Activated d16HER2 homodimers and SRC kinase signaling axis is a predictor of Trastuzumab benefit Lorenzo Castagnoli (Fondazione IRCCS - Istituto Nazionale dei Tumori, Dept. Experimental Oncology and Molecular Medicine, Milan, Italy), Manuela Iezzi, Valentina Ciravolo, Gaia Cristina Ghedini, Tiziana Triulzi, Patrizia Gasparini, Roberta Zappasodi, Patrizia Nanni, Elda Tagliabue, Serenella Pupa P 25 Predictive biomarkers of trabectedin (TR) and PARP-1 inhibitor synergism in preclinical models of mesenchymal tumors (MTs) Ymera Pignochino (Candiolo Cancer Institute, IRCCS, University of Torino Medical School, Candiolo, Turin, Italy), Federica Capozzi, Carmine Dell’Aglio, Marta Canta, Marco Basiricò, Annalisa Lorenzato, Lorenzo D’ambrosio, Danilo Galizia, Maria Serena Benassi, Massimo Aglietta, Giovanni Grignani P 26 TAK1-regulated expression of BIRC3 is responsible for chemoradiotherapy (CRT) resistance in esophagogastric junction (EGJ) adenocarcinoma Geny Piro (Laboratory of Oncology and Molecular Therapy, University of Verona, Verona, Italy), Simone Giacopuzzi, Maria Bencivenga, Giuseppe Verlato, Carmine Carbone, Valeria Merz, Anna Tamburrino, Giovanni de Manzoni, Giampaolo Tortora, Davide Melisi P9 Clinical relevance of circulating endothelial cells as prognostic and early predictive biomarker of response to anti-angiogenic therapy in rectal cancer patients Elena Di Gennaro (Istituto Nazionale per lo Studio e la Cura dei Tumori, “Fondazione Giovanni Pascale”- IRCCS – Italia, Naples, Italy), Paolo Delrio, Alessandra Leone, Tania Moccia, Eleonora Cardone, Carmen Romano, Antonio Avallon, Alfredo Budillon 11 Friday September 12th Scientific Programme Venue: POLO CHIMICO BIO MEDICO (Mammut) 12 14.00 - 15.30 Poster Discussion 4 DRUG RESISTANCE, SIGNAL TRANSDUCTION, TARGETED THERAPY Chairs: Gaia Cristina Ghedini (Milan, Italy), Marco Macagno (Turin, Italy) Room D7 A3 GSK3A and GSK3B isoforms are redundant in modulating drug resistance and chemotherapy-induced necroptosis of p53-null colon cancer cells Marialuisa Lavitrano (Department of Surgery and Translational Medicine, University of Milan - Bicocca, Milan, Italy), Emanuela Grassilli, Leonarda Ianzano, Fabio Pisano, Sara Bonomo, Carola Missaglia, Laura Masiero, Maria Grazia Cerrito, Gabriele Romano, Serena Bonin, Giorgio Stanta, Roberto Giovannoni I1 CDK6 and platinum drug resistance in Epithelial Ovarian Cancer Alessandra Dall’Acqua (CRO of Aviano, National Cancer Institute, Aviano, Italy), Monica Schiappacassi, Maura Sonego, Ilenia Pellizzari, Gustavo Baldassarre I8 GENE expression profiling of Human Melanoma cell lines and clinical samples defines subsets differing in susceptibility to BRAFV600E and pathway-directed inhibitors Marialuisa Sensi (Fondazione IRCCS Istituto Nazionale dei Tumori, Hospital, Milan, Italy), Matteo Dugo, Gabriella Nicolini, Gabrina Tragni, Ilaria Bersani, Antonella Tomassetti, Silvana Canevari, Andrea Anichini Q1 Multicomponent Nanovectors for Delivery of Therapeutic Molecules in Cancer Armando Cevenini (CEINGE-Biotecnologie Avanzate, s.c.a r.l., Naples, Italy), Alessandro Parodi, SM Khaled, Iman K Yazdi, Matteo Ciancaioni, Xueavu Liu, Christian Celia, Nicoletta Peluso, Rosa Peltrini, Stefania Orrù, Luigi Del Vecchio, Ennio Tasciotti, Mauro Ferrari, Francesco Salvatore S4 Interaction between Sonic hedgehog and bombesin neuropeptide receptor pathways in small cell lung carcinoma Maria Domenica Castellone (Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy), Mikko Olavi Laukkanen, Silvio Gutkind S3 The Double-Stranded RNA Adenosine Deaminase, ADAR1, Represents a Novel Substrate for AKT William Blalock (Institute of Molecular Genetics-National Research Council of Italy (IGMCNR), Rizzoli Orthopedic Institute, Bologna, Italy), Mirco Raffini, Manuela Piazzi, Irene Faenza, Alberto Bavelloni T7 Effects of Hedgehog signaling inhibition on epithelial-stromal interactions in triple negative breast cancer cells. Concetta Di Mauro (Department of molecular medicine and surgery, University of Naples Federico II, Naples, Italy), Roberta Rosa, Valentina D’Amato, Luigi Formisano, Roberta Marciano, Lucia Raimondo, Alberto Servetto, Bianca Maria Veneziani, Sabino De Placido, Roberto Bianco Friday September 12th Scientific Programme Venue: POLO CHIMICO BIO MEDICO (Mammut) 15.30 - 16.45 Session 3a: CANCER STEM CELLS Chairs: Silvano Capitani (Ferrara, Italy), Elda Tagliabue (Milan, Italy) 15.30 - 16.00 Towards new therapy based on Cancer Stem Cell Targeting Ruggero De Maria (Rome, Italy) 16.00 - 16.15 Surgery-induced wound response promotes stem-like and tumor‑initiating features of breast cancer cells via STAT3 signaling C 18 Ilenia Segatto (CRO of Aviano, National Cancer Institute, Aviano, Italy), Stefania Berton, Maura Sonego, Samuele Massarut, Tiziana Perin, Gustavo Baldassarre, Barbara Belletti 16.15 - 16.45 Dynamics of cancer stem cells in the pancreas Christopher Heeschen (Madrid, Spain) 16.45 - 17.15 Coffee Break 17.15 - 18.00 Session 3b: CANCER STEM CELLS Chairs: Paolo Pinton (Ferrara, Italy), Gabriella Sozzi (Milan, Italy) Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast Alessandro Zannini (Laboratorio Nazionale cib, Dipartimento Scienze della Vita - Università degli Studi di Trieste, Trieste, Italy), Alessandra Rustighi, Elena Campaner, Giovanni Sorrentino, Silvano Piazza, Giannino Del Sal Connecting the machineries of tumor suppression and cell fate determination in stem cells Pier Paolo Di Fiore (Milan, Italy) 17.15 - 17.30 C 21 17.30 - 18.00 18.15 - 19.15 SIC General Assembly 20.15 Social Dinner 13 Saturday September 13th Scientific Programme Venue: POLO CHIMICO BIO MEDICO (Mammut) 08.30 - 09.15 Plenary Lecture Restoration of anticancer immunosurveillance: a hallmark of successful antineoplastic therapies Guido Kroemer (Villejuif, France) 09.15 - 11.30 09.15 - 09.45 09.45 - 10.15 Session 4: “TRANSLATIONAL” THERAPY Chairs: Rita Falcioni (Rome, Italy), Antonio Frassoldati (Ferrara, Italy) State of the art and perspectives for the development of targeted therapies Giampaolo Tortora (Verona, Italy) Genomics of Hairy Cell Leukemia: biological and clinical implication Brunangelo Falini (Perugia, Italy) 10.15 - 10.45 Next generation personalized medicine in colon and lung cancer Nicola Normanno (Naples, Italy) - Sponsored by EACR 10.45 - 11.30 11.15 - 11.30 Companies lectures Chair: Massimo Negrini (Ferrara, Italy), Unlocking cancer with multiomic approach: from sample to data analysis Valentina Maran (Sales Channel Manager Genomics Italy Diagnostic and Genomics Group, Agilent Technologies) Droplet Digital PCR, new and enabling tool for cancer research Alessandro Martino (Field Application Specialist Southern Europe Bio-Rad Laboratories S.r.l. Life Science Group) The latest news in NGS Cancer clinical research with Ion Torrent Alberto Madini (Sales Rep., Life Sciences Solution, Thermo Fisher Scientific) 11.30 - 12.30 Award Ceremony “Piero Trivella” and “EACR” Awards for the best posters “Elena Cappannini” Award for the best 2013 publication “Pezcoller Foundation” scholarship 2013-2014 winner award Characterization of molecular mechanisms involved in MDSC mediated tolerance: paving the way to overcome tumor attack Samantha Solito (Department of Surgery, Oncology and Gastroenterology, University of Padua) “Pezcoller Foudation” scholarship 2015-2016 award Travel Grants 12.30 - 13.30 Light Lunch 10.45 - 11.00 11.00 - 11.15 14 Saturday September 13th Scientific Programme Venue: POLO CHIMICO BIO MEDICO (Mammut) 13.30 - 14.15 Giorgio Prodi Lecture Regulation of Self Renewal in Cancer Stem Cells Pier Giuseppe Pelicci (Milan, Italy) 14.15 - 15.45 Session 5: TRANSLATIONAL DIAGNOSTICS: NGS, CIRCULATING CELLS\NUCLEIC ACIDS Chairs: Mattia Boeri (Milan, Italy), Davide Melisi (Verona, Italy) Disseminated and circulating tumor cells as prognostic and predictive markers Simon Joosse (Eppendorf, Germany) A specific and sensitive method for the individuation of EGFR mutations in circulating free tumor DNA from NSCLC patients Raffaella Pasquale (Istituto Nazionale Tumori “Fondazione G. Pascale”-IRCCS, Cell Biology and Biotherapy Unit, Naples, Italy), Anna Maria Rachiglio, Claudia Esposito, Alessandra Sacco, Riziero Esposito Abate, Simona Bevilacqua, Cristin Roma, Antonella De Luca, Nicola Normanno Circulating tumour DNA as a biomarker of response in cancer therapy James Brenton (Cambridge, UK) Early relapse upon trastuzumab treatment is predictable by transcriptome analysis of primary HER2-positive breast cancer Tiziana Triulzi (Fondazione IRCCS Istituto Nazionale dei Tumori, Department of Experimental Oncology and Molecular Medicine, Milan, Italy), Loris De Cecco, Aleix Prat, Marco Sandri, Marta Giussani, Maria Luisa Carcangiu, Silvana Canevari, Serena Di Cosimo, Sylvie Menard, Manuela Campiglio, Elda Tagliabue 14.15 - 14.45 14.45 - 15.00 P 20 15.00 - 15.30 15.30 - 15.45 P 29 15.45 - 16.30 Closing Lecture Deconstructing the molecular genetics of human cancer and its therapeutic implications Pier Paolo Pandolfi (Boston, Massachussets, USA) 16.30 - 17.00 Closing Remarks 15 Scientific Information CME CREDITS No. 3,2 Italian Ministry of Health CME (Continuing Medical Education) credits have been assigned for the following Professions and Disciplines: Profession: Medical Surgeon (Disciplines: Haematology, Medical Genetics, Pathological Anatomy, Pharmacology and Clinical Toxicology, Clinical Pathology, Internal Medicine); Biologist, Pharmacist, Chemist (Discipline: Analytical Chemistry); Physicist (Discipline: Health Physics); Veterinary Surgeon. SLIDES Slides must be in English. Computer videoprojection will be available in Power Point. Please communicate to the Organizing Secretariat your different requirements as soon as possible. Slides have to be handed to the slide centre one hour before the session beginning. PRIZES Saturday September 13th 2014 “Piero Trivella” and “EACR” Awards for the best posters “Elena Cappannini” Award for the best 2013 publication “Pezcoller Foudation” Ferruccio and Elena Bernardi scholarship Award Travel Grants 16 SIC SECRETARIAT Società Italiana di Cancerologia Via G. Venezian, 1 - 20133 Milan, Italy Phone +39 02 2666895 - Fax +39 02 2664342 E-mail: [email protected] - www.cancerologia.it ORGANIZING SECRETARIAT C.S.C. S.r.l. Via L.S. Gualtieri, 11 - 06123 Perugia Tel+390755730617 - Fax +390755730619 www.csccongressi.it General Information DATES Ferrara 11th -13th September 2014 CONGRESS VENUE Università degli Studi di Ferrara - Via Luigi Borsari, 46 44121 Ferrara OPENING CEREMONY VENUE Azienda Ospedaliero Universitaria di Ferrara Arcispedale Sant’Anna - Via Aldo Moro, 8 - 44124 Cona – Ferrara OFFICIAL LANGUAGE English. Simultaneous translation will not be provided. BADGE Participants and exhibitors are kindly requested to wear their badge during the congress. CERTIFICATE OF ATTENDANCE Certificate of attendance is given to all registered participants at the end of the congress. EXHIBITION AND SPONSORSHIP A technical, pharmaceutical and publication exhibition will be held in the Congress Venue. For any information please contact the Organizing Secretariat. REGISTRATION FEE SIC MEMBER NON SIC MEMBER SIC MEMBER UNDER 35 NON SIC MEMBER UNDER 35 On site € 420,00 € 520,00 € 260,00 € 335,00 VAT 22% Included. Registration Fee Includes: Admission to the scientific sessions, admission to the exhibit area, congress kit, abstract book, attendance certificate, welcome cocktail, coffee-breaks, light lunches and social dinner. Online registration available at www.csccongressi.it PAYMENT Payment online: by bank transfer or credit card data collection Payment on site: by cash or credit card (accepted VISA and MASTERCARD) CANCELLATION In case of cancellation no reimbursement is foreseen. 17 General Information Congress Venue ingressi 1: ingresso auto (parcheggio interno non a pagamento) 2: ingresso pedonale 3: ingresso auto (parcheggio area Sant’Anna non a pagamento) Altri parcheggi a pagamento a: Rampari San Rocco b: Fossato di Mortara Da stazione ferroviaria TAXI (circa 10 eur) Autobus n. 1 diretto a Rampari San Rocco (1,50 eur) Da Aeroporto Bologna Navetta “Bus & Fly” arriva in Stazione Ferroviaria (15,00 eur) HOW TO REACH THE CONGRESS VENUES By Car Motorway A13, exit Ferrara South Parking area: • Inside the “MAMMUT” (entrance 1) • Inside the ex-hospital St. Anna (entrance 3) • Along the Rampari of San Rocco or Fossato di Mortara (toll parking - 2,00 Euros for the entire day) By train Ferrara stop From the station to the congress venue: • by taxi •bus N. 1 Rampari San Rocco stop, in front of the MAMMUT 18 By plane From Bologna Marconi Airport to Ferrara Shuttle “BUS & FLY” (Time: 60 minutes. Cost: 15,00 Euros). It stops in the city center and at the train station. Walking From the city center 15 min walking distance By bus bus N. 1 Rampari San Rocco stop, in front of the MAMMUT General Information Opening Day Venue HOW TO REACH THE OPENING DAY VENUE By Car Motorway A13, exit Ferrara South Then proceed straight for about 10 km on the highway RA8 (Raccordo Ferrara-Mare) to the exit Cona Parking area: in the free parking lots of the hospital By bus bus n. 6, starting at various bus stops in from center city every 15 minutes. It stops right in front of the Conference Hall 19 Thanks to