HEART FAILURE AT CROSSROADS Bergamo (Italy), November 27th - 29th, 2014 Organized by CLINICAL RESEARCH FOUNDATION, BERGAMO HOSPITAL (FROM) AZIENDA OSPEDALIERA PAPA GIOVANNI XXIII - BERGAMO Promoted by FONDAZIONE INTERNAZIONALE MENARINI Under the Auspice of FIC – Italian Federation of Cardiology Thursday, November 27th, 2014 – Afternoon Teatro Sociale - Via Colleoni, 4 - Bergamo 04.00 p.m. - 05.00 p.m. Saluti di Benvenuto / Welcome Addresses Alessandro Casini, President of “Fondazione Internazionale Menarini” Carlo Nicora, General Director, “Ospedale Papa Giovanni XXIII”, Bergamo Tiziano Barbui, Scientific Director, FROM Fondazione per la Ricerca, Ospedale Papa Giovanni XXIII, Bergamo Antonello Gavazzi, FROM Fondazione per la Ricerca, Ospedale Papa Giovanni XXIII, Bergamo Michele Senni, Cardiologia 1 – Scompenso e Trapianti di Cuore, Ospedale Papa Giovanni XXIII, Bergamo 05.00 p.m. - 06.00 p.m. Lettura Magistrale / Keynote Address Mihai Gheorghiade Heart Failure Research over the last 10 years: the Last Unconquered Frontier in Cardiology 06.00 p.m. - 06.30 p.m. Question and answers Discussion 06.30 p.m. - 08.00 p.m. Tavola rotonda sui “Network di Patologia” / Round Table on “Pathology Networks” Mihai Gheorghiade, Michele Senni, Antonello Gavazzi, Tiziano Barbui Friday, November 28th, 2014 – Morning Session I: Chairpersons: 08.30 a.m. - 08.45 a.m. 08.45 a.m. - 09.00 a.m. 09.00 a.m. - 09.15 a.m. 09.15 a.m. - 09.30 a.m. 09.30 a.m. - 10.00 a.m. 10.00 a.m. - 10.30 a.m. Session II: Chairpersons: 10.30 a.m. - 10.45 a.m. Course Meeting Directors Worsening Heart Failure Andrea Di Lenarda Giuseppe Ambrosio Claudia Vittori Case Presentation Discussant: Michele Emdin Javed Butler What is worsening heart failure? Definition, epidemiology and classification Mihai Gheorghiade Worsening chronic heart failure: end stage disease or salvageable? Aldo Pietro Maggioni Worsening hospitalized heart failure: finally a surrogate marker among hospitalized heart failure patients? Discussion Coffee break New Target - New Therapies Giuseppe Di Tano Maurizio Porcu Emilia D’Elia Case presentation Discussant: Elisabeth K. Krainer Antonello Gavazzi FROM Foundation for Research - Bergamo, I Adrian Voors Targets to develop novel heart failure therapies – returning to the heart 11.00 a.m. - 11.15 a.m. Javier Diez The next decade of trials and therapies for heart failure with reduced ejection fraction 11.15 a.m. - 11.30 a.m. Marco Metra Hospitalized heart failure: acute therapies, chronic therapies, or bridging therapies? 11.30 a.m. - 12.00 a.m. Discussion 12.00 a.m. - 02.00 p.m. Lunch 10.45 a.m. - 11.00 a.m. Friday, November 28th, 2014 – Afternoon Session III: Chairpersons: 02.00 p.m. - 02.15 p.m. 02.15 p.m. - 02.30 p.m. 02.30 p.m. - 02.45 p.m. 02.45 p.m. - 03.00 p.m. 03.00 p.m. - 03.15 p.m. 03.15 p.m. - 03.45 p.m. 03.45 p.m. - 04.15 p.m. Session IV: Chairpersons: 04.15 p.m. – 04.30 p.m. 04.30 p.m. - 04.45 p.m. 04.45 p.m. – 05.15 p.m. 05.15 p.m. – 06.30 p.m. Michele Senni Cardiologia 1 - Scompenso e Trapianti di Cuore Azienda Ospedaliera Papa Giovanni XXIII Bergamo, I Mihai Gheorghiade Experimental Therapeutics, Center for Cardiovascular Innovation Northwestern University Feinberg School of Medicine - Chicago, USA Beyond Drugs – Alternative Therapeutics Options Luca Ferdinando Lorini Fabrizio Oliva Attilio Iacovoni Case presentation Discussant: Francesco Grigioni Andrea Mortara Ambulatory monitoring – options and outcomes Gaetano Maria De Ferrari The future of stem cell therapy for heart failure Maria Frigerio Circulatory support future Alec Vahanian MitraClip Discussion Coffee break Heart Failure with preserved ejection fraction: New directions Massimo Volpe Nadia Aspromonte Michele Senni Lessons learned from heart failure with preserved ejection fraction trials Burkert Mathias Pieske Next Steps: Outpatient versus Hospitalized patient Mauro Gori, Aurelia Grosu Cases presentation Discussant: Marco Guazzi, Javier Diez Questions and answers Discussion Scientific Secretary Marilisa Ambrosio Azienda Ospedaliera Papa Giovanni XXIII Bergamo, I Fumiko Inoue Project Organizer Logica Med Saturday, November 29th, 2014 – Morning Session V: Chairpersons: 08.00 p.m. – 08.15 a.m. 08.15 p.m. – 08.30 a.m. 08.30 a.m. – 08.45 a.m. 08.45 a.m. – 09.00 a.m. 09.00 a.m. – 09.15 a.m. 09.15 a.m. – 09.30 a.m. 09.30 a.m. – 10.15 a.m. 10.15 a.m. – 10.30 a.m. Session VI: Chairpersons: 10.30 a.m. – 10.45 a.m. 10.45 a.m. – 11.00 a.m. 11.00 a.m. – 11.15 a.m. 11.15 a.m. – 11.30 a.m. 11.30 a.m. – 11.45 a.m. 11.45 a.m. – 12.45 p.m. 12.45 p.m. – 01.45 p.m. 01.45 p.m. – 02.05 p.m. 02.05 p.m. – 03.35 p.m. Promoted by Fondazione Internazionale Menarini Edificio L – Strada 6 Centro Direzionale Milanofiori I-20089 Rozzano (Milan, Italy) Phone: +39 02 55308110 Fax: +39 02 55305739 E-mail: [email protected] Http://www.fondazione-menarini.it HF in patients with Diabetes Mellitus: a distinct entity Cheuk-Man Yu Naoki Sato Alice Calabrese Case presentation Discussant: Renata De Maria Alessandra Dei Cas Epidemiology and significance Giovanni Cioffi Pathophysiology of heart failure with diabetes mellitus Ovidiu Chioncel The role of kidney in patients with diabetes mellitus and heart failure Roberto Trevisan Treatment of diabetes mellitus in patients with heart failure Frank Edelmann Treatment of heart failure in patients with diabetes mellitus and future directions Discussion Coffee break Workshop: clinical trials and future directions Savina Nodari Mihai Gheorghiade Robert O. Bonow Lessons learned from past heart failure trials Mihai Gheorghiade Proof of concepts study – from animal models to human models and the role of T1 centers Antonello Gavazzi Matching the drug with the right patients population Luigi Tavazzi What are the appropriate endpoints for heart failure trials Cheuk-Man Yu Trial execution enrollment, retention Lessons from Registries: Andrew Ambrosy, Ovidiu Chioncel, Naoki Sato, Luigi Tavazzi Globalization of heart failure trials: good or bad? Discussion Conclusion and Future Directions Antonello Gavazzi, Mihai Gheorghiade, Michele Senni CME/ECM questionnaires Organizing Secretariat Servizi C.E.C. S.r.l. Via Verdi, 18 - I-24121 Bergamo (Italy) Phone: +39 035 249899 Provider ECM MZ Congressi S.r.l. Provider accreditato n. 966 Via Carlo Farini, 81 - I-20159 Milan (Italy) Phone: +39 02 66802323