Page 1 of 18 Perinetti G Curriculum Vitae Giuseppe Perinetti DDS, MS, PhD Date of Birth: Place of Birth: Nationality: ORCID Registry: 8 October, 1976 Valencia, Venezuela Italian http://orcid.org/0000-0002-7226-5134 Professional Address: Department of Medical, Surgical and Health Sciences School of Dentistry University of Trieste Ospedale Maggiore Piazza Ospitale, 1 34129 Trieste Italy University contacts Tel.: +39(0)403992114 Email: [email protected] Freelance contacts www.culturaortodontica.it [email protected] EDUCATION: 1995 2008 2011 Bachelor in Chemistry at the ‘Luigi Di Savoia’ Technical Institute, Chieti, Italy, with maximum marks. Doctor in Dental Surgery (DDS) at the ‘G. D’Annunzio’ University, Chieti, Italy, with maximum marks. Doctor of Philosophy (PhD) at the ‘Open University’, Milton Keynes, United Kingdom. Master of Science (MS, Orthodontics) at the ‘University of Trieste’, Trieste, Italy. Licensure: 2000 2001 2011 2012 Italian Dental Board Full registration, Ordine dei Medici e degli Odontoiatri di Pescara. Incognito, Lingual Orthodontic System Invisalign, Clear Orthodontic System Honours: 2000 2000 2011 Doctor in Dental Surgery ‘Summa cum Laude’ Doctor in Dental Surgery ‘Special mention’ Master of Science in Orthodontics ‘Summa cum Laude’ Awards: 2010 2010 2011 Italian Society of Orthodontics (SIDO): ‘National Prize’ Italian Society of Orthodontics (SIDO): ‘Best poster’ Italian Board of Professors in Dentistry: ‘Best poster’ 2000 Languages: Italian: Mother tongue English: Fluent February 2014 Page 2 of 18 Perinetti G CLINICAL AND RESEARCH EXPERIENCE (from most recent): 2009-present Part-time Research Associate, Department of Medical, Surgical and Health Sciences, School of Dentistry, University of Trieste, Trieste, Italy. 2004-present Part-time Associate in private dental practice (Orthodontics), Pescara and Pordenone, Italy. 2013 2013 2011-2013 2009-2011 2010 2009 2005-2008 2008 2007 2007 2004-2007 2004-2005 2002-2003 2001-2002 2000-2001 Visiting Scientist, Faculty of Dentistry, University of Ljubljana, Ljubljana, Slovenia. Visiting Scientist, School of Dentistry, University of Insubria, Varese, Italy. Visiting Scientist, School of Dentistry, Second University of Naples, Naples, Italy. Resident, Orthodontic Programme, Department of Biomedicine, Trieste. Visiting Scientist, Faculty of Dentistry, University of Hong Kong, Hong Kong SAR, China. Visiting Scientist, Faculty of Biology, University of Siena, Siena, Italy. PhD Student, Open University (UK), Department of Cell Biology and Oncology, ‘Consorzio Mario Negri Sud’ Institute (as a sponsoring establishment), Santa Maria Imbaro, Italy. Visiting Scientist, Faculty of Dentistry, University of Florence, Florence, Italy. Visiting Scientist, Faculty of Dentistry, University of Hong Kong, Hong Kong, SAR, China. Visiting Scientist, School of Life Sciences, Oxford Brookes University, Oxford, UK. Visiting Scientist (5 periods), Department of NanoBiophotonics, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany. Research Fellow, Department of Cell Biology and Oncology, ‘Consorzio Mario Negri Sud’ Institute. Research Fellow, Department of Oral Sciences, ‘G. D’Annunzio’ University, Chieti, Italy Research Fellow, Department of Cell Biology and Oncology, ‘Consorzio Mario Negri Sud’ Institute. Research Fellow, Department of Oral Sciences, ‘G. D’Annunzio’ University, Chieti, Italy. RESEARCH TECHNIQUES (in bold, most used and familiar with): 1. Biochemical: SDS-PAGE, Western blotting, spectrophotometry, G-protein binding assays, ADP-ribosylation assays. 2. Cell Biology: Cell culture, cell transfection, cell microinjection, cell electroporation. 3. Morphology: Confocal laser-scanning microscopy (CLSM) Transmission electron microscopy (TEM) Correlative light-electron microscopy (CLEM) 4Pi-microscopy and correlative 4Pi-CLEM (developed during my PhD). Zero-crossing image segmentation (developed during my PhD). 4. Software Packages: Mac and PC Windows operating systems. Office: Word, Excel, PowerPoint, Access. Graphic suites: Corel Draw. Morphology: Visual Molecular Dynamics (VMD), Imspector, Imod, ImageJ. Statistics: Statistical Package for Social Sciences (SPSS), Comprehensive Metaanalysis (CMA), RevMan, GraphPad Prism. Cephalometrics: Viewbox MAIN STATISTICAL KNOWLEDGE: 1. Descriptive Statistics: mean, median, standard deviation, percentiles, etc. 2. Bayesian Statistics: sensitivity, specificity, predictive value, accuracy, likelihood ratio. February 2014 Page 3 of 18 Perinetti G 3. Inferential Statistics: a. Univariate or bivariate: i. Parametric: one-way and multi-way analysis of variance (ANOVA) for repeated measures or independent samples, paired sample t-test, independent sample t-test, bivariate linear regression, rho correlation coefficient. ii. Non-parametric: Friedman test, Wilcoxon test, Kruskal-Wallis test, Mann-Whitney test, Cochrane test, Chi-squared test, Fisher exact test, Spearman correlation coefficient. iii. Sample size calculation, power analysis. b. Multivariate: i. Parametric: one-way and multi-way multivariate analysis of variance (MANOVA) for repeated measures or independent samples; multiple linear regression. ii. Non-parametric: multiple binomial logistic regression, multiple multinomial logistic regression. 4. Repeatability/agreement/method error analysis: Cohen kappa, weighted kappa, intraclass correlation coefficient, Kendall W, etc. 5. Meta-analysis: effect sizes, summary effects, heterogeneity, forest plots, etc. ARTICLE WRITING: I have myself written most of the articles that I have published, and I currently perform all of the statistical analyses myself for my papers, and even for the epidemiological studies and meta-analyses. February 2014 Page 4 of 18 Perinetti G MAIN POSITIONS AND COLLABORATIONS: 1. I entered the Dental School of the ‘G. D’Annunzio’ University of Chieti in 1995 and obtained my degree in Dentistry in November 2000. In the 4th year of my course, I started to work in the laboratories of the Department. In particular, I began in the biochemical laboratory of Prof. Giuseppe Spoto, where my research was mainly focused on the enzymatic activities in inflamed dental pulp and in gingival crevicular fluid. 2. After I received my degree in Dentistry, I remained as a Research Fellow in the Department of Oral Sciences for seven months, before spending some months on a Research Fellowship at the ‘Consorzio Mario Negri Sud’ Institute. Then, from May 2002 to January 2004, I had a position as a Research Fellow in the same Department of Oral Sciences (at the ‘G. D’Annunzio’ University). 3. Subsequently, in the period from August 2005 to December 2008, I returned to the ‘Consorzio Mario Negri Sud’ Institute and entered the PhD Programme in ‘Life Sciences’. In particular, I worked in the Unit of Protein Sorting and Biogenesis, headed by Dr Roman Polishchuk, which was part of the Laboratory of Membrane Traffic of Dr Alberto Luini (who was the Head of the Department of Cell Biology and Oncology at that time). While the ‘Consorzio Mario Negri Sud’ Institute was a sponsoring establishment, the University holding the PhD programme was the Open University, UK, and according to its regulations, Prof. Christopher Hawes (Research School of Biological and Molecular Sciences, Oxford Brookes University, Oxford, UK) was my English Supervisor. 4. Since the completion of my PhD, from January 2009, I have been in the School of Dentistry at the University of Trieste where I got my Master of Science Degree in Orthodontics. At present, I hold a post-doctoral position within the Department of Medical, Surgical and Health Sciences, headed by Prof. Roberto Di Lenarda, within the same University of Trieste. In general, most of my current research activity is into the orthodontic field. At the same time and since 2004, I have been involved in a private dental practice in Orthodontics. 5. Finally, until 2010 I kept some collaborations with my former Department of Oral Sciences (‘G. D’Annunzio’ University) and Department of Cell Biology and Oncology (now known as ‘Cellular and Translational Pharmacology’) which is limited to statistical advice and morphometric analyses. February 2014 Page 5 of 18 Perinetti G MAIN PAST AND PRESENT ACTIVITIES ACCORDING TO EACH FIELD: (please refer to publication list ordered by topic; underlined, most important research activities) A. Biomedical and clinical studies in Orthodontics I started with studies into the modifications of gingival crevicular fluid during orthodontic treatment. In particular, I focused on modifications to its enzymatic activity during tooth movement. However, my main activities at present are related to biomarkers of skeletal maturation in growing subjects. At present, reliable methods of diagnosis rely on radiographical methods that are thus invasive to the patients, while noninvasive methods would be preferable. In this regard, we have initially demonstrated that the gingival crevicular fluid composition, and in particular its alkaline phosphatase activity, is sensitive to systemic growth, and are investigating the possibilities of its use as a non-invasive biomarker for skeletal maturation. More research is in progress to further define the use and reliability of this biomarker. Apart from these biochemical investigations, I have also been investigating the diagnostic performance of other morphological indices of skeletal maturity, such as dental maturation. At present, investigations on the biochemical or morphological of skeletal maturation represent my main research activity. B. Other clinical studies As a second research line, I have investigated the relationships between dental occlusion/TMJ disorders and body posture, as recorded through static posturography. The results of these studies, which do not support aspects of previously published data, showed no detectable correlations. More recently, I have been involved in systematic reviews of the topic. According to our results, detectable correlations do exist, but they would be of little or no clinical relevance, even when considering patients with temporomandibular disorders. C. Epidemiological studies In 2003, I was the main assessor for the orthodontic part of the Italian OHSAR Survey, in which about 1,200 mixed dentition children were monitored for their malocclusal traits. As with the caries part of this project, this is to date among the most comprehensive surveys performed in Italian children. We described the prevalence of several malocclusal traits in Italian mixed-dentition children, along with their main correlations. This was achieved using the dental class (canine or molar) as dependent variable, and then correlating all of the other traits in a multivariate model. D. Biological Studies My biological studies were mainly performed during my two periods at the Consorzio Mario Negri Sud (CMNS) Institute. In the first, short-terms stay, from June 2001-April 2002, I was initially working under the direct supervision of Dr Maria Di Girolamo within the projects investigating the role and regulation of endogenous mono-ADP-ribosylation of the heterotrimeric G protein β subunit. At my second and longer period at the CMNS from 2004 to 2008, I was involved in the PhD Programme project that was an investigation into the morphological features relating to intra-Golgi transport, as revealed through a novel technique known as ultra-high resolution laser scanning microscopy (4Pi-microscopy). This project was a collaboration between the CMNS and the Department of NanoBiophotonics at the Max-Planck Institute for Biophysical Chemistry (Göttingen, Germany), headed by Dr Stefan Hell, who is also the developer of 4Pimicroscopy (http://www.4pi.de/). In particular, in collaboration with other researchers, I validated the imaging acquired by this novel instrument by developing the new process that we call ‘correlative 4Pi-electron microscopy’ (4Pi-CLEM). Here, the very same cell structures seen under 4Pi-microsopy can also be found at the electron microscopy level, so that direct comparisons of both of these imaging technologies can be made. Moreover, the difficulty of obtaining true structural boundaries from complex intensity curves, a specific problem that has limited the use of fluorescence microscopy for morphometrical analyses, was overcome by our novel objective image segmentation method, referred as the zero-crossings procedure. Finally, I have also had collaborations within my former Department of Cell Biology and Oncology which have led to further co-authorships. February 2014 Page 6 of 18 Perinetti G E. Teaching/Lecturing activities Since 2009, I have been involved in teaching/ lecturing activities both within and outside the University of Trieste, into the following topics: BDS students: Basics of dentofacial orthopaedics with emphasis on treatment timing Post-graduate students: Principles of biostatistics Basic research methodology Indicators of skeletal maturity Courses/Congresses (national and international): Clinical implications of the biology of orthodontic tooth movement Biomedical research methodology Posturography in Dentistry Evidence-based treatment of Class II malocclusion F. Undergraduate and postgraduate students supervision Since 2003, I have had major responsibilities in supervising both undergraduate and postgraduate MS (Orthodontics) students in the management of their theses. This activity was kept even during my PhD term when I was primarily working at the CMNS Institute outside the Dental School. To date, a total of over 30 undergraduate or postgraduate students have been fully supervised in their research activities, and thesis writing and dissertation. My supervision related to studies into the orthodontic or periodontal fields, and most of these theses have been published on international peer-reviewed journals. At present, about 2 undergraduate and 2 postgraduate dental students per year at the University of Trieste are under my supervision. G. Clinical activities My clinical activities are all in orthodontics. Since January 2004, I have been working ‘freelance’ in the orthodontic field. In particular, I am working in private officers in Pescara and Pordenone (Italy). At present, about 200 patients have undergone or are undergoing my treatments. Overall, since the beginning in 2004, about 30% of my time has been spent in this clinical activity (about 5%-10% during my PhD up to about 60% at present). My clinical activity includes interceptive and dentofacial orthopedics, as well as full fixed appliance therapies. I also manage adult patients undergoing combined orthodontic treatment combined to and maxillo-facial surgery. H. Reviewer activities Since 2003, I have been a reviewer for the Angle Orthodontist, the American Journal of Orthodontics and Dentofacial Orthopedics, Journal of Oral Rehabilitation and European Journal of Oral Sciences. In particular, I have been asked to review manuscripts related to biological aspects of orthodontic tooth movement, and to the correlations between dental occlusion and posture. In 2009, I also joined the Editorial Board of the American Journal of Orthodontics and Dentofacial Orthopedics. I. Assistant Editor activities Since January 2011 until beginning 2013, I have been an Assistant Editor of Progress in Orthodontics, the official journal of the Mediterranean Integrated Orthodontic Project (MIOP), which was founded in 2000 by the Italian Society of Orthodontics. Progress in Orthodontics at that time present edited by Dr Lorenzo Franchi. February 2014 Page 7 of 18 Perinetti G J. Peer review activities (no., number of manuscripts reviewed since 2002) Journal 1. Acta Odontologica Scandinava 2. American Journal of Orthodontics and Dentofacial Orthopedics 3. BMC Oral Health 4. Caries Research 5. Clinics 6. Drug Discovery Today 7. European Journal of Oral Sciences 8. European Journal of Orthodontics 9. European Polymer Journal 10. International Scholarly Research Network (ISNR) Dentistry 11. Journal of Contemporary Dental Practice 12. Journal of Electromyography and Kinesiology 13. Journal of Oral Rehabilitation 14. Journal of Periodontology 15. Journal of Zhejiang University SCIENCE B 16. Oral Health and Preventive Dentistry 17. Orthodontics and Craniofacial Research 18. Progress in Orthodontics 19. The Angle Orthodontist Total February 2014 No. 2 17 5 1 1 1 8 2 1 5 1 1 3 1 1 4 4 16 15 89 Page 8 of 18 Perinetti G MEMBERSHIPS: 1. European Orthodontic Society (since 2010) 2. Italian Orthodontic Society (2010-2013) EDITORIAL BOARDS: 1. American Journal of Orthodontics and Dentofacial Orthopedics (since 2009) 2. International Scholarly Research Network (ISNR) Dentistry (since 2012) EDITORIAL OFFICE MANAGEMENT: 1. Progress in Orthodontics, Assistant Editor (2011-2012) INTERNATIONAL LECTURING ACTIVITIES: 1. The impact of anti-inflammatory drugs on orthodontic tooth movement and the diagnostic potential of the crevicular fluid. 36th International Annual Conference on Craniofacial Research. Ann Arbor, Michigan. February 26, 2010 (invited Speaker). 2. Gingival crevicular fluid alkaline phosphate activity as a marker of skeletal maturation. 86th Congress of the European Orthodontic Society, Portorož, Slovenia. June 15-19, 2010 (Finalist at the WJB Houston Memorial Research Awards). 3. Posturography: A true diagnostic aid in dentistry? Congress of the European Academy of Craniomandibular Disorders. Naples, Italy. September 23-26, 2010 (invited Speaker). 4. Correlations between the stomatognathic system and body posture: A systematic review of electromyographic data. XXII International Congress of the Italian Society of Orthodontics. Florence, Italy. November 26-27, 2010. 5. Biomarkers: New tools for orthodontic treatment planning. th American Association of Orthodontics, 11 Annual Session. Chicago, Michigan. May 13-17, 2011 (invited Speaker). 6. Static posturography and dental occlusion: A platform test-retest and reliability analysis and a metaanalysis of reported changes. XXIII International Congress of the Italian Society of Orthodontics. Rome, Italy. November 11-12, 2011. 7. Dentofacial orthopedics for Class II malocclusion: The evidence-based approach. International Congress of the Spanish Society of Orthodontics. Madrid, Spain. November 22-23, 2013. (invited Speaker). February 2014 Page 9 of 18 Perinetti G PUBLICATIONS SUMMARY: Published papers: First/last author: Corresponding author: Letters to the Editor: Editorials: Book chapters: 68 37 38 4 1 3 Total 76 AUTHOR’S CITATIONS AND IMPACT POINTS Total citations 801 [www.scopus.com] H-Index 16 [www.scopus.com] PAPERS PUBLISHED IN PEER-REVIEWED JOURNALS: Ordered by date within each topic including the journal impact factor corresponding to the year of publication (or most recent where not applicable). A. Orthodontics, biomarkers of tooth movement and growth: 1. Perinetti G, Paolantonio M, D'Attilio M, D'Archivio D, Tripodi D, Femminella B, Festa F, Spoto G. Alkaline phosphatase activity in gingival crevicular fluid during human orthodontic tooth movement. Am J Orthod Dentofacial Orthop 2002;122:548-56. (Impact factor: 0.732) 2. Perinetti G, Paolantonio M, D'Attilio M, D'Archivio D, Dolci M, Femminella B, Festa F, Spoto G. Aspartate aminotransferase activity in gingival crevicular fluid during orthodontic treatment. A controlled short-term longitudinal study. J Periodontol 2003;74:145-52. (Impact factor: 1.490) 3. Serra E, Perinetti G, D’Attilio M, Cordella C, Paolantonio M, Festa F, Spoto G. Lactate dehydrogenase activity in gingival crevicular fluid during orthodontic treatment. Am J Orthod Dentofacial Orthop 2003;124:206-11. (Impact factor: 0.840) 4. Perinetti G, Varvara G, Festa F, Esposito P. Aspartate aminotransferase activity in human dental pulps of orthodontically treated teeth. Am J Orthod Dentofacial Orthop 2004;125:88-92. (Impact factor: 0.880) 5. Perinetti G, Paolantonio M, D’Archivio D, Serra E, D’Ercole S, Festa F, Spoto G. Longitudinal monitoring of subgingival colonization by Actinobacillus actinomycetemcomitans, and crevicular alkaline phosphatase and aspartate aminotransferase activities around orthodontically treated teeth. J Clin Periodontol 2004;31:60-7. (Impact factor: 1.644) 6. D’Attilio M, Di Maio F, D’Arcangela C, Filippi MR, Felaco M, Lohinai Z, Festa F, Perinetti G. Gingival endothelial and inducible nitric oxide synthase levels during orthodontic treatment. A crosssectional study. Angle Orthod 2004;74:849-56. (Impact factor: 0.782) 7. Perinetti G, Serra E, Paolantonio M, Bruè C, Di Meo S, Filippi MR, Festa F, Spoto G. February 2014 Page 10 of 18 Perinetti G Lactate dehydrogenase activity in human gingival crevicular fluid during orthodontic treatment: A controlled short-term longitudinal study. J Periodontol 2005;76:411-17. (Impact factor: 1.784) 8. Perinetti G, Varvara G, Salini S, Tetè S. Alkaline phosphatase activity in human dental pulps of orthodontically treated teeth. Am J Orthod Dentofacial Orthop 2005;128:492-96. (Impact factor: 0.916) 9. Perinetti G, Baccetti T, Di Lenarda R, Contardo L. Gingival crevicular fluid alkaline phosphatase activity as a non-invasive biomarker of skeletal maturation. Orthod Craniofac Res 2011;14:44-50. (Impact factor: 1.607) 10. Perinetti G, Baccetti T, Di Leonardo B, Di Lenarda R, Contardo L. Dentition phase and chronological age in relation to gingival crevicular fluid alkaline phosphatase activity in growing subjects. Prog Orthod 2011; 12:100-106. (Impact factor: none) 11. Drummond S, Canavarro C, Perinetti G, Palmier Teles R, Capelli J Jr. The monitoring of gingival crevicular fluid volume during orthodontic treatment. A longitudinal randomised split-mouth study. Eur J Orthod 2012;34:109-113. (Impact factor: 1.078) 12. Perinetti G, Contardo L, Baccetti T, Gabrieli PF, Di Lenarda R. The diagnostic performance of dental maturity in the identification of the pubertal growth spurt. Eur J Orthod 2012;34:487-492. (Impact factor: 1.078) 13. Primožič J, Perinetti G, Richmond S, Ovsenik M. Three-dimensional evaluation of palatal vault changes in children. A longitudinal study. Angle Orthod 2012;82:632-636. (Impact factor: 1.184) 14. Perinetti G, Franchi L, Di Lenarda R, Contardo L. Gingival crevicular fluid protein content and alkaline phosphatase activity in relation to the pubertal growth phase. Angle Orthod 2012;82:1047-1052. (Impact factor: 1.184) 15. Primožič J, Perinetti G, Richmond S, Ovsenik M. Assessment of facial asymmetry in growing subjects with a three-dimensional laser scanning system. Orthod Craniofac Res 2012;15:237-244. (Impact factor: 1.186) 16. Primožič J, Farcnik F, Perinetti G, Richmond S, Ovsenik M. The association of tongue posture with the dentoalveolar maxillary and mandibular morphology in Class III malocclusion: a controlled study. Eur J Orthod 2013;35:388-93. (Impact factor: 1.078) 17. Primožič J, Perinetti G, Richmond S, Ovsenik M. Three-dimensional evaluation of facial asymmetry in association with unilateral functional crossbite in the primary, early, and late mixed dentition phases. Angle Orthod 2013;83:253-8. (Impact factor: 1.184) 18. Primožič J, Franchi L, Perinetti G, Richmond S, Ovsenik M. Influence of sucking habits and breathing pattern on palatal constriction in unilateral posterior crossbite - a controlled study. February 2014 Page 11 of 18 Perinetti G Eur J Orthod 2013;35:706-12. (Impact factor: 1.078) 19. Perinetti G, Primožič J, Castaldo A, Di Lenarda R, Contardo L. Is gingival crevicular fluid volume sensitive to orthodontic tooth movement? A meta-analysis of splitmouth longitudinal studies. Orthod Craniofac Res 2013;16:1-19. (Impact factor: 1.186) 20. Primožič J, Perinetti G, Contardo L, Ovsenik M. The diagnostic performance of three-dimensional evaluation of palatal vault changes in assessing successful treatment for constricted maxilla in growing subjects. Am J Orthod Dentofacial Orthop 2013;143:42-49. (Impact factor: 1.458) 21. Perinetti G, Westphalen GH, Biasotto M, Salgarello S, Contardo L. The diagnostic performance of dental maturity in the identification of the pubertal growth spurt: A meta-analysis. Prog Orthod 2013; 14:8. (Impact factor: none) 22. Perinetti G, Di Lenarda R, Contardo L. Diagnostic performance of individual and combined canine and second molar maturity for identification of growth phase. Prog Orthod 2013;14:1. (Impact factor: none) 23. Perinetti G, Callovi M, Salgarello S, Biasotto M, Contardo L. Eruption of the permanent maxillary canines in relation to mandibular second molar maturity. Angle Orthod 2013;83:578-83. (Impact factor: 1.184) 24. Perillo L, Femiano A, Palumbo S, Contardo L, Perinetti G. Skeletal and dental effects produced by Functional Regulator-2 in pre-pubertal Class II patients: A controlled study. Prog Orthod 2013;14:18. (Impact factor: none) 25. Ovsenik M, Perinetti G, Zhurov A, Richmond S, Primožič J. Three-dimensional assessment of facial asymmetry among pre-pubertal class III subjects: a controlled study Eur J Orthod 2013; Epub. (Impact factor: 1.078) B. Gnatology/Posture: 26. D'Attilio M, Di Meo S, Perinetti G, Filippi MR, Tecco S, D'Alconzo F, Festa F. Effects of the antigravitary modification of the myotension of asset (MAGMA) therapy on myogenic cranio-cervical-mandibular dysfunction: a longitudinal surface electromyography analysis. Cranio 2003;21:24-30. (Impact factor: 0.375) 27. Perinetti G. Dental occlusion and body posture: no detectable correlation. Gait Posture 2006;24:165-8. (Impact factor: 1.976) 28. Perinetti G. Temporomandibular disorders do not correlate with detectable alterations in body posture. J Contemp Dent Pract 2007;8:60-7. (Impact factor: none) 29. Perinetti G, Contardo L. February 2014 Page 12 of 18 Perinetti G Posturography as a diagnostic aid in dentistry: a systematic review. J Oral Rehabil 2009;36:922-36. (Impact factor: 1.356) 30. Perinetti G, Contardo L, Biasati AS, Perdoni L, Castaldo A. Dental malocclusion and body posture in young subjects: a multiple regression study. Clinics (Sao Paulo) 2010;65:689-95. (Impact factor: 1.591) 31. Perillo L, Femminella B, Farronato D, Baccetti T, Contardo L, Perinetti G. Do malocclusion and Helkimo Index ≥5 correlate with body posture? J Oral Rehabil 2011;38:242-52. (Impact factor: 1.529) 32. Perinetti G, Türp JC, Primožič J, Di Lenarda R, Contardo L. Associations between the masticatory system and muscle activity of the other body districts. A metaanalysis of surface electromyography studies. J Electromyogr Kinesiol 2011;21-877-84. (Impact factor: 1.969) 33. Perinetti G, Marsi L, Castaldo A, Contardo L. Is postural platform suited to study correlations between dental occlusion and body posture? A study of repeatability and a meta-analysis of reported variations. Prog Orthod 2012;13:273-80. (Impact factor: none) 34. Manfredini D, Castroflorio T, Perinetti G, Guarda-Nardini L. Dental occlusion, body posture, and temporomandibular disorders: Where we are now and where we are heading for. J Oral Rehabil 2012;39:463-71. (Impact factor: 2.344) 35. Perinetti G, Primožič J, Di Lenarda R, Contardo L. The diagnostic potential of static body-sway recording in dentistry: A systematic review and metaanalysis. Eur J Orthod 2013;35:696-05. (Impact factor: 1.078) 36. Manfredini D, Perinetti G, Guarda-Nardini L. Dental malocclusion is not related to temporomandibular joint clicking: a logistic regression analysis in a patient population. Angle Orthod 2013; Epub. (Impact factor: 1.184) 37. Perinetti G, Monsurrò A, Contardo L, Perillo L. Diagnostic accuracy of body sway parameters in the identification of forward standing posture J Man Phy Ther 2014; In press. (Impact factor: 1.647) C. Periodontology: 38. Paolantonio M, Dolci M, Esposito P, D'Archivio D, Lisanti L, Di Luccio A, Perinetti G. Subpedicle acellular dermal matrix graft and autogenous connective tissue graft in the treatment of gingival recessions: a comparative 1-year clinical study. J Periodontol 2002;73:1299-307. (Impact factor: 1.854) 39. Paolantonio M, D'Ercole S, Perinetti G, Tripodi D, Catamo G, Serra E, Bruè C, Piccolomini R. Clinical and microbiological effects of different restorative materials on the periodontal tissues adjacent to subgingival class V restorations. J Clin Periodontol 2004;31:200-7. (Impact factor: 1.644) February 2014 Page 13 of 18 Perinetti G 40. Perinetti G, Paolantonio M, Cordella C, D'Ercole S, Serra E, Piccolomini R. Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients. J Clin Periodontol 2004;31:273-81. (Impact factor: 1.644) 41. D'Ercole S, Piccolomini R, Capaldo G, Catamo G, Perinetti G, Guida L. Effectiveness of ultrasonic instruments in the therapy of severe periodontitis: a comparative clinicalmicrobiological assessment with curettes. New Microbiol 2006;29:101-10. (Impact factor: 0.806) 42. Paolantonio M, D'Angelo M, Grassi RF, Perinetti G, Piccolomini R, Pizzo G, Annunziata M, D'Archivio D, D'Ercole S, Nardi G, Guida L. Clinical and microbiologic effects of subgingival controlled-release delivery of chlorhexidine chip in the treatment of periodontitis: a multicenter study. J Periodontol 2008;79:271-82. (Impact factor: 1.961) 43. Perinetti G, Paolantonio M, Femminella B, Serra E, Spoto G. Gingival crevicular fluid alkaline phosphatase activity reflects periodontal healing/recurrent inflammation phases in chronic periodontitis patients. J Periodontol 2008;79:1200-7. (Impact factor: 1.961) 44. Paolantonio M, Perinetti G, D'Ercole S, Graziani F, Catamo G, Sammartino G, Piccolomini R. Internal decontamination of dental implants: an in vivo randomized microbiologic 6-month trial on the effects of a chlorhexidine gel. J Periodontol 2008;79:1419-25. (Impact factor: 1.961) 45. Paolantonio M, Perinetti G, Dolci M, Perfetti G, Tete S, Sammartino G, Femminella B, Graziani F. Surgical treatment of periodontal intrabony defects with calcium sulfate implant and barrier versus collagen barrier or open flap debridement alone: a 12-month randomized controlled clinical trial. J Periodontol 2008;79:1886-93. (Impact factor: 1.961) 46. Paolantonio M, D'Ercole S, Pilloni A, D'Archivio D, Lisanti L, Graziani F, Femminella B, Sammartino G, Perillo L, Tetè S, Perfetti G, Spoto G, Piccolomini R, Perinetti G. Clinical, microbiologic, and biochemical effects of subgingival administration of a Xanthan-based chlorhexidine gel in the treatment of periodontitis: a randomized multicenter trial. J Periodontol 2009;80:1479-92. (Impact factor: 2.192) 47. Paolantonio M, Femminella B, Coppolino E, Sammartino G, D'Arcangelo C, Perfetti G, Perinetti G. Autogenous periosteal barrier membranes and bone grafts in the treatment of periodontal intrabony defects of single-rooted teeth: a 12-month reentry randomized controlled clinical trial. J Periodontol 2010;81:1587-95. (Impact factor: 2.479) 48. Perinetti G, Di Leonardo B, Di Lenarda R, Contardo L. Repeatability of the gingival crevicular fluid collection and measurement, as determined through alkaline phosphatase activity: Implications for diagnostic uses. J Periodont Res 2013;48:98-104. (Impact factor: 1.990) D. Cell biology: 49. Liberali P, Kakkonen E, Turacchio G, Valente C, Spaar A, Perinetti G, Böckmann RA, Corda D, Colanzi A, Marjomaki V, Luini A. The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS. February 2014 Page 14 of 18 Perinetti G EMBO J 2008;27:970-81. (Impact factor, 8.295) 50. Perinetti G, Muller T, Spaar A, Polishchuk R, Luini A, Egner A. Correlation of 4Pi and electron microscopy to study transport through single Golgi stacks in living cells with super resolution. Traffic 2009;10:379-91. (Impact factor, 6.255). 51. Finetti F, Paccani SR, Riparbelli MG, Giacomello E, Perinetti G, Pazour GJ, Rosenbaum JL, Baldari CT. Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse. Nat Cell Biol 2009;11:1332-9. (Impact factor, 19.527). 52. Micaroni M, Perinetti G, Di Giandomenico D, Bianchi K, Spaar A, Mironov AA. Synchronous intra-Golgi transport induces the release of Ca2+ from the Golgi apparatus. Exp Cell Res 2010;316:2071-86. (Impact factor, 3.609). 53. Micaroni M, Perinetti G, Berrie CP, Mironov AA. The SPCA1 Ca2+ pump and intracellular membrane trafficking. Traffic 2010;11:1315-33. (Impact factor, 5.278). 54. Capestrano M, Mariggiò S, Perinetti G, Egorova AV, Iacobacci S, Di Pentima A, Iurisci C, Egorov M, Di Tullio G, Buccione R, Luini A, Polishchuk RS Cytosolic phospholipase A2 drives recycling in the clathrin-independent endocytic route. J Cell Sci 2013; (Impact factor, 5.278). E. Epidemiology (Italian OHSAR Survey, Cariology/Malocclusion): 55. Perinetti G, Caputi S, Varvara G. Risk/prevention indicators for the prevalence of dental caries in schoolchildren: results from the Italian OHSAR Survey. Caries Res 2005;39:9-19. (Impact factor: 1.721) 56. Perinetti G, Varvara G, Esposito P. Prevalence of dental caries in schoolchildren living in rural and urban areas: results from the first region-wide Italian survey. Oral Health Prev Dent 2006;4:199-207. (Impact factor: none) 57. Perinetti G, Cordella C, Pellegrini F, Esposito P. The prevalence of malocclusal traits and their correlations in mixed dentition children: results from the Italian OHSAR Survey. Oral Health Prev Dent 2008;6:119-29. (Impact factor: none) F. Dental materials: 58. Varvara G, Perinetti G, Di Iorio D, Murmura G, Caputi S. In vitro evaluation of fracture resistance and failure mode of internally restored endodontically treated maxillary incisors with differing heights of residual dentin. J Prosthet Dent 2007;98:365-72. (Impact factor: 1.009) 59. Vidoni G, Perinetti G, Antoniolli F, Castaldo A, Contardo L. February 2014 Page 15 of 18 Perinetti G Combined aging effects of strain and thermocycling on unload deflection modes of nickel-titanium closed-coil springs: an in-vitro comparative study. Am J Orthod Dentofacial Orthop 2010;138:451-57. (Impact factor: 1.354) 60. Perinetti G, Contardo L, Ceschi M, Antoniolli F, Franchi L, Baccetti T, Di Lenarda R. Surface corrosion and fracture resistance of two nickel-titanium-based archwires induced by fluoride, pH, and thermocycling. An in vitro comparative study. Eur J Orthod 2012;34:1-9. (Impact factor: 1.078) 61. Contardo L, Perinetti G, Castaldo A, Franchi L, Baccetti T, Di Lenarda R. Effects of deflection and archwire dimension on the mechanical performance of two self-ligating orthodontic systems. Prog Orthod 2012;13:2-9. (Impact factor: none) G. Miscellaneous: 62. Spoto G, Fioroni M, Rubini C, Tripodi D, Perinetti G, Piattelli A. Aspartate aminotransferase activity in human healthy and inflamed dental pulps. J Endod 2001;27:394-5. (Impact factor: 0.668) 63. Esposito P, Varvara G, Caputi S, Perinetti G. Catalase activity in human healthy and inflamed dental pulps. Int Endod J 2003;36:599-603. (Impact factor: 1.312) 64. Varvara G, Esposito P, Franchini F, Perinetti G, Caputi S. A positioning device for computed tomography: a clinical report. J Prosthet Dent 2003;89:123-6. (Impact factor: 0.527) 65. Varvara G, Traini T, Esposito P, Caputi S, Perinetti G. Copper-zinc superoxide dismutase activity in healthy and inflamed human dental pulp. Int Endod J 2005;38:195-9. (Impact factor: 1.606) 66. Biasotto M, Perinetti G, Serroni I, Ottaviani G, Di Lenarda R, Tirelli G. Oral manifestation upon short time cocaine abuse. A case report. Minerva Stomatol 2012 ;61:295-298. (Impact factor: none) 67. Ottaviani G, Costantinides F, Perinetti G, Luzzati R, Contardo L, Visintini E, Tirelli G, Di Lenarda R, Gobbo M, Biasotto M. Epidemiology and variables involved in dental abscess: survey of dental emergency unit in Trieste. Oral Dis 2013; Epub. (Impact factor: 2.377) 68. Ottaviani G, Gobbo M, Sturnega M, Martinelli V, Mano M, Zanconati F, Bussani R, Perinetti G, Long CS, Di Lenarda R, Giacca M, Biasotto M, Zaccchigna S. Effect of Class IV Laser Therapy on Chemotherapy-Induced Oral Mucositis: A Clinical and Experimental Study. Am J Pathol 2013; Epub. (Impact factor: 4.522) Book chapters (peer-reviewed): 69. Perinetti G, Contardo L, Franchi L, Baccetti T. The biology of orthodontic tooth movement and the impact of anti-inflammatory drugs. February 2014 Page 16 of 18 Perinetti G In: McNamara JA Jr, Hatch N, Kapila SD, editors. Effective and Efficient Orthodontic Tooth Movement. Craniofacial Growth Series, Department of Orthodontics and Pediatric Dentistry and Center for Human Growth and Development, The University of Michigan. Ann Arbor: Needham Press; 2011. p. 117-40. 70. Perinetti G, Contardo L, Baccetti T. The gingival crevicular fluid as a source of biomarkers of patient responsiveness to orthodontic treatment. In: McNamara JA Jr, Editor. Taking advantage of emerging technologies in clinical practice. Craniofacial Growth Series, Department of Orthodontics and Pediatric Dentistry and Center for Human Growth and Development, The University of Michigan. Ann Arbor: Needham Press; 2012. p. 197-221. 71. Franchi L, Contardo L, Primožič J, Perinetti G. Clinical alteration of mandibular growth: what we know after 40 years. In: McNamara JA Jr, Editor. The 40th Moyers Symposium: Looking Back…Looking Forward. Craniofacial Growth Series, Department of Orthodontics and Pediatric Dentistry and Center for Human Growth and Development, The University of Michigan. Ann Arbor: Needham Press; 2014 in press. Editorials: 72. Perinetti G. Correlations between the stomatognathic system and body posture: biological or clinical implications? Clinics (Sao Paulo) 2009;64:77-8. Letters to the Editor: 73. Perinetti G. Putting research into clinical training. Am J Orthod Dentofacial Orthop 2007;132:717-8. 74. Perinetti G. The friction concept must acknowledge the biology of tooth movement. Am J Orthod Dentofacial Orthop 2008;134:468-9. 75. Perinetti G. Low-friction systems: in vitro veritas? Am J Orthod Dentofacial Orthop 2009;136:756. 76. Perinetti G. Dr. Giuseppe Perinetti comments on Dr. Nozomi Maeda, et al.'s article (pps. 194-203) in CRANIO's July, 2011 issue. Cranio 2011; 29:253-4; According to Italian Law: Autorizzo il trattamento dei miei dati ai sensi del Decreto Legislativo n. 196 del 30.06.2003 (Testo Unico sulla Privacy). Giuseppe Perinetti, DDS, MS, PhD February 2014
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