Hybrid Materials for Biomedical Applications Luisa De Cola

Scuola di dottorato
Università degli Studi di Milano-Bicocca
Lunedì 13 ottobre 2014 – ore 15.00
Aula U4-08, Piazza della Scienza 4 – 20126 Milano
Hybrid Materials for Biomedical
Luisa De Cola
Institut des Sciences et d’ Ingenierie Supramoleculaires, ISIS, Université de Strasbourg,
Porous systems, and especially those where it is possible to control the chemical composition as well as
their size, aspect ratio and pores dimension are of great interest for the development of new materials,
catalysis, sensors, biolabels, drug delivery…. The talk will illustrate some of the recent results on inert or
active inorganic nanocontainers such as microporous and mesoporous silica based nanoparticles. In
particular examples using the crystalline allumino silicates, zeolite L, and mesoporous organosilicates
will be discussed since these materials can act as nanocontainers and due to their biocompatibility used
for biomedical applications. Indeed the organization of molecules or atoms in ordered channels can lead
to very special properties absent in any other condition. The porous systems can also be functionalized
of their surface and it will be shown that the particles can be decorated with different functional groups
including biocompatible molecules and are able to perfom drug and PNA or DNA delivery inside the cell
or even transfection. The delivery can be probed by kinetic analyses after the nanoparticles
internalization. A new strategy to obtain containers that can undergo destruction inside the cell or by an
external input will be illustrated as a promising approach to clearance of such materials in vivo,
independently from their initial size. With such an approach the delivery of enzymes and proteins is also
possible and some very recent results will be presented. Finally the implementation of porous systems
in biocompatible hydrogel has been investigated with the aim to create new 3D scaffold for cell growth
and differentiation.
Università degli Studi di Milano-Bicocca
Piazza dell'Ateneo Nuovo, 1 - 20126, Milano Tel. +39.02.6448.1 - www.unimib.it