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教員氏名 徳田 裕(とくだ ゆたか) 取得学位 医学博士

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教員氏名 徳田 裕(とくだ ゆたか)
取得学位 医学博士
現在の身分(役職名) 教授
専門分野
乳腺内分泌外科学
現在の研究課題
所属学会
日本外科学会,日本乳癌学会,日本癌学会,日本癌治療学会,
日本臨床腫瘍学会,日本臨床外科学会,日本造血細胞移植学会
American Society of Clinical Oncology, American Association for
Cancer Research
教員紹介
領域(医学部組織)
外科学系 乳腺・内分泌外科学
専門分野キーワード
乳腺内分泌
研究内容
近年,日本人の死亡原因の第1位は,悪性新生物となり,乳癌の罹患率は年々増加している.現在で
は,女性の悪性新生物の第1位を占め,今後もさらに増加することが予想されている.したがって,乳癌
に対するさらなる診断技術の向上と治療法の開発が期待されている.そこで,当研究室では,最近,1.
診断技術の向上を目的に,(1)Ki-67 index の臨床的意義の確立. 2.治療成績の向上を目的に,(1)
HER2 陽性乳癌における新規 anthracycline と trastuzumab 併用の有用性の検討,(2)apoptosis 誘導
HER2 ペプチドによるワクチン療法の開発,などの研究をすすめている.その他にも新しい薬剤の治験
ならびに多施設共同研究による臨床研究をおこなっている
主要論文:
1. Niikura N, Masuda S, Kumaki N, Xiaoyan T, Terada M, Terao M, Iwamoto T,Oshitanai R, Morioka T,
Tuda B, Okamura T, Saito Y, Suzuki Y, Tokuda Y.Prognostic Significance of the Ki67 Scoring
Categories in Breast Cancer Subgroups. Clin Breast Cancer. 2013 Dec 30.
2. Niikura N, Odisio BC, Tokuda Y, Symmans FW, Hortobagyi GN, Ueno NT. Latest biopsy approach for
suspected metastases in patients with breast cancer. Nat Rev Clin Oncol. 2013 Dec;10(12):711-9.
3. Noguchi S, Masuda N, Iwata H, Mukai H, Horiguchi J, Puttawibul P, Srimuninnimit V, Tokuda Y, Kuroi
K, Iwase H, Inaji H, Ohsumi S, Noh WC, Nakayama T, Ohno S, Rai Y, Park BW, Panneerselvam A,
El-Hashimy M, Taran T, Sahmoud T, Ito Y. Efficacy of everolimus with exemestane versus
exemestane alone in Asian patients with HER2-negative, hormone-receptor-positive breast
cancer in BOLERO-2. Breast Cancer. 2013 Feb 13.
4. Inaji H, Iwata H, Nakayama T, Yamamoto N, Sato Y, Tokuda Y, Aogi K, Saji S, Watanabe K, Saito T,
Yoshida M, Sato N, Saeki T, Takatsuka Y, Kuranami M, Yamashita H, Kikuchi A, Tabei T, Ikeda T,
Noguchi S. Randomized phase II study of three doses of oral TAS-108 in postmenopausal patients
with metastatic breast cancer. Cancer Sci. 2012 Sep;103(9):1708-13.
5. Niikura N, Iwamoto T, Masuda S, Kumaki N, Xiaoyan T, Shirane M, Mori K, Tsuda B, Okamura T,
Saito Y, Suzuki Y, Tokuda Y. Immunohistochemical Ki67 labeling index has similar proliferation
predictive power to various gene signatures in breast cancer. Cancer Sci. 2012
Aug;103(8):1508-12.
6. 6.
Toi M, Saeki T, Iwata H, Inoue K, Tokuda Y, Sato Y, Ito Y, Aogi K, Takatsuka Y, Arioka H. A
multicenter phase II study of TSU-68, an oral multiple tyrosine kinase inhibitor, in combination with
docetaxel in metastatic breast cancer patients with anthracycline resistance. Breast Cancer. 2014
Jan;21(1):20-7.
7. Tamaki Y, Sato N, Homma K, Takabatake D, Nishimura R, Tsujimoto M, Yoshidome K, Tsuda H,
Kinoshita T, Kato H, Taniyama K, Kamio T, Nakamura S, Akiyama F, Noguchi S; Japanese One-Step
Nucleic Acid Amplification Study Group. Routine clinical use of the one-step nucleic acid
amplification assay for detection of sentinel lymph node metastases in breast cancer patients:
results of a multicenter study in Japan. Cancer. 2012 Jul 15;118(14):3477-83.
8. Nakamura S, Ando M, Masuda N, Aogi K, Ino H, Iwata H, Tokuda Y, Yamamoto N, Kasai H, Takeuchi
M, Tsuda H, Akiyama F, Kurosumi M, Fujiwara Y. Randomized phase II study of primary systemic
chemotherapy and trastuzumab for operable HER2 positive breast cancer. Clin Breast Cancer.
2012 Feb;12(1):49-56.
9. Niikura N, Liu J, Hayashi N, Palla SL, Tokuda Y, Hortobagyi GN, Ueno NT, Theriault RL.
Retrospective analysis of antitumor effects of zoledronic acid in breast cancer patients with
bone-only metastases. Cancer. 2012 Apr 15;118(8):2039-47.
10. Saji S, Hiraoka M, Tokuda Y, Fukui N, Ikeda T. Trends in local therapy application for early breast
cancer patients in the Japanese Breast Cancer Society Breast Cancer Registry during 2004-2009.
Breast Cancer. 2012 Jan;19(1):1-3..
11. Niikura N, Liu J, Hayashi N, Mittendorf EA, Gong Y, Palla SL, Tokuda Y, Gonzalez-Angulo AM,
Hortobagyi GN, Ueno NT. Loss of human epidermal growth factor receptor 2 (HER2) expression in
metastatic sites of HER2-overexpressing primary breast tumors. J Clin Oncol. 2012 Feb
20;30(6):593-9.
12. Niikura N, Kimura M, Iwamoto T, Hayashi N, Shintoku J, Saito Y, Suzuki Y, Tokuda Y. Women prefer
adjuvant endocrine therapy to chemotherapy for breast cancer treatment. Breast Cancer. 2013
Jan;20(1):67-74.
13. Berry DA, Ueno NT, Johnson MM, Lei X, Caputo J, Rodenhuis S, Peters WP, Leonard RC, Barlow WE,
Tallman MS, Bergh J, Nitz UA, Gianni AM, Basser RL, Zander AR, Coombes RC, Roché H, Tokuda Y,
de Vries EG, Hortobagyi GN, Crown JP, Pedrazzoli P, Bregni M, Demirer T. High-dose chemotherapy
with autologous stem-cell support as adjuvant therapy in breast cancer: overview of 15 randomized
trials. J Clin Oncol. 2011 Aug 20;29(24):3214-23.
Copyright (C) 2014 東海大学大学院医学研究科. All Rights Reserved.
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